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https://www.readbyqxmd.com/read/27926652/hysteroscopic-sterilization-with-essure-summary-of-the-u-s-food-and-drug-administration-actions-and-policy-implications-for-postmarketing-surveillance
#1
Jessica R Walter, Comeron W Ghobadi, Emily Hayman, Shuai Xu
In September 2015, the U.S. Food and Drug Administration (FDA) convened a meeting of the Obstetrics and Gynecology Advisory Board Committee to address the sudden increase of patient-reported adverse events surrounding Essure, a Class III device offering a less invasive method for permanent female sterilization. After a review of the premarketing and postmarketing data and existing scientific literature, the FDA concluded there was insufficient evidence to remove the device from the market. However, the FDA did release a new guidance document requiring a black box warning for the device and ordered a new postmarketing study comparing Essure's safety and efficacy with laparoscopic tubal sterilization...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27892642/new-approaches-to-non-surgical-sterilization-for-dogs-and-cats-opportunities-and-challenges
#2
Linda Rhodes
Over the last 40 years, researchers have explored methods to non-surgically suppress fertility in animals. Immunocontraception has been used to control wildlife populations but does not confer long-term immunity. The gonadotropin-releasing hormone (GnRH) agonist deslorelin, formulated as an implant to provide 6-month to 1-year suppression of fertility in male dogs, is available commercially in some countries. Neither of these approaches provide permanent sterility. A single-dose, permanent treatment would be a valuable tool in dog and cat population control...
November 28, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27883303/transgender-reproductive-choice-and-fertility-preservation
#3
Khadija Mitu
Increasing numbers of young transgender people are now using medical technologies to achieve a physical gender transition. However, the procedures of physical gender transition might cause temporary or permanent sterility. Thus many transgender people are now using fertility preservation technologies. Nonetheless, they can experience dilemmas in making reproductive and family-building decisions and face challenges in gaining access to and utilizing fertility preservation services. Based on qualitative research conducted with transgender men and women who used reproductive technologies for preserving their fertility before or during their physical transition, this paper contributes to the discourse of reproductive choice by the inclusion of transgender people's experience...
November 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/27865415/biosterilant-effects-of-bacillus-thuringiensis-kurstaki-hd-73-extract-on-male-wistar-albino-rats
#4
Vikas Kumar Roy, Vanlal Peki, Maibam Sunita Devi, Sanasam Sanjeev, Maurya Khusboo, R Zothansanga, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Guruswami Gurusubramanian
Chemosterilants have long been used in sterilization programs for managing pet, stray, and wild animals but adverse effects such as trauma, incomplete responses to treatment, and complete abolition of gonadal sources of testosterone often occurs. This study describes the biosterilant effects of administering three doses of Bacillus thuringiensis kurstaki HD-73 (Bt 5, 50, and 250 mg/kg; 20 rats/dose) extract in adult male Wistar albino rats on testicular parameters, function, histology, and a number of biochemical markers of overall health, free radical production, and cell proliferation...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27859771/engineering-a-gene-silencing-viral-construct-that-targets-the-cat-hypothalamus-to-induce-permanent-sterility-an-update
#5
G A Dissen, K Adachi, A Lomniczi, T Chatkupt, B L Davidson, H Nakai, S R Ojeda
The intent of this contribution is to provide an update of the progress we have made towards developing a method/treatment to permanently sterilize cats. Our approach employs two complementary methodologies: RNA interference (RNAi) to silence genes involved in the central control of reproduction and a virus-based gene therapy system intended to deliver RNAi selectively to the hypothalamus (where these genes are expressed) via the systemic administration of modified viruses. We selected the hypothalamus because it contains neurons expressing Kiss1 and Tac3, two genes essential for reproduction and fertility...
November 17, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27854119/clinical-applications-of-genome-editing-to-hiv-cure
#6
Cathy X Wang, Paula M Cannon
Despite significant advances in HIV drug treatment regimens, which grant near-normal life expectancies to infected individuals who have good virological control, HIV infection itself remains incurable. In recent years, novel gene- and cell-based therapies have gained increasing attention due to their potential to provide a functional or even sterilizing cure for HIV infection with a one-shot treatment. A functional cure would keep the infection in check and prevent progression to AIDS, while a sterilizing cure would eradicate all HIV viruses from the patient...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27837564/preservation-of-ocular-epithelial-limbal-stem-cells-the-new-frontier-in-regenerative-medicine
#7
Zala Lužnik, Marina Bertolin, Claudia Breda, Barbara Ferrari, Vanessa Barbaro, Petra Schollmayer, Stefano Ferrari
Significant advances have been made in the field of ocular regenerative medicine. Promising stem cell-based therapeutic strategies have been translated into the clinical practice over the last few decades. These new stem cell-based therapies offer the possibility of permanently restoring corneal epithelium in patients with severe disabling and blinding ocular surface disease. The European Union has already classified stem cell-based therapies as "medicinal products". Therefore, manipulation is strictly regulated according to the defined conditions of good manufacturing practice, with the production of stem cell therapeutics at only accredited production sites authorized by the national regulatory agencies...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27834415/antimicrobial-influence-of-different-root-canal-filling-techniques-in-experimentally-infected-human-root-canals
#8
Christian Tennert, Tilman Schurig, Ali Al-Ahmad, Sabrina Lydia Strobel, Andrej M Kielbassa, Karl-Thomas Wrbas
OBJECTIVE: The aim of the present study was to evaluate the antimicrobial influence of different root canal filling techniques using gutta-percha and an epoxy resin-based sealer in experimentally infected root canals of extracted human teeth. METHOD AND MATERIALS: In total, 96 intact sterilized, permanent human anterior teeth and premolars with single patent root canals were prepared and infected with a clinical isolate of Enterococcus faecalis. After 72 hours, all root canals were sampled using three sterile paper points...
November 10, 2016: Quintessence International
https://www.readbyqxmd.com/read/27823943/patient-provider-conversations-about-sterilization-a-qualitative-analysis
#9
Katrina Kimport, Christine Dehlendorf, Sonya Borrero
OBJECTIVES: Although female sterilization is the second most commonly used contraceptive method in the US, research suggests that providers may serve as barriers to desired sterilization. STUDY DESIGN: We conducted a modified grounded theory analysis of audio-recorded contraceptive counseling visits with 52 women who specified on a previsit survey that they wanted no future children and a supplemental analysis of visits with 14 women who wanted or were unsure about future children in which sterilization was mentioned...
November 4, 2016: Contraception
https://www.readbyqxmd.com/read/27809979/reproductive-failures-associated-with-trypanosoma-duttonella-vivax
#10
REVIEW
Oscar Jaime Betancur Hurtado, Pablo David Jimenez Castro, Cristian Giraldo-Ríos
Trypanosomosis is a disease of a high economic impact in different productive livestock systems, especially in Africa and South America; cattle, sheep, goats, horses and donkeys can be prone to infection. Trypanosoma vivax is a blood parasite normally associated with a case of anemia and persistent febrile status, which causes a reduction in production, weakness of affected animals and occasionally death. However, the reproductive disorders which include abortion, disruption of the estrous cycle, placental retention, perinatal mortality, among others, can be very severe, especially when they occur during the last third of gestation...
October 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27768038/the-synthesis-of-rgd-functionalized-hydrogels-as-a-tool-for-therapeutic-applications
#11
Emanuele Mauri, Alessandro Sacchetti, Filippo Rossi
The use of polymers as biomaterials has provided significant advantages in therapeutic applications. In particular, the possibility to modify and functionalize polymer chains with compounds that are able to improve biocompatibility, mechanical properties, or cell viability allows the design of novel materials to meet new challenges in the biomedical field. With the polymer functionalization strategies, click chemistry is a powerful tool to improve cell-compatibility and drug delivery properties of polymeric devices...
October 7, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27700983/non-surgical-sterilisation-methods-may-offer-a-sustainable-solution-to-feral-horse-equus-caballus-overpopulation
#12
Sally Elizabeth Hall, Brett Nixon, R John Aitken
Feral horses are a significant pest species in many parts of the world, contributing to land erosion, weed dispersal and the loss of native flora and fauna. There is an urgent need to modify feral horse management strategies to achieve public acceptance and long-term population control. One way to achieve this is by using non-surgical methods of sterilisation, which are suitable in the context of this mobile and long-lived species. In this review we consider the benefits of implementing novel mechanisms designed to elicit a state of permanent sterility (including redox cycling to generate oxidative stress in the gonad, random peptide phage display to target non-renewable germ cells and the generation of autoantibodies against proteins essential for conception via covalent modification) compared with that of traditional immunocontraceptive approaches...
October 5, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27687852/laparoscopic-removal-of-a-retroperitoneal-hysteroscopic-microinsert-using-fluoroscopy-a-case-report
#13
Heather Wahl, Jason Bell, Bethany Skinner
Perforation during placement of hysteroscopic microinserts for permanent sterilization occurs in approximately 0.9-2.6% of women undergoing the procedure. Most of the time perforation results in; intraperitoneal placement of the hysteroscopic microinsert requiring laparoscopy or laparotomy for; removal of the device. Herein we present a case of hysteroscopic microinsert perforation with; subsequent retroperitoneal identification of the device. This is the first such case to our knowledge of; retroperitoneal identification and retrieval of a perforated device which required real-time fluoroscopy; during laparoscopy...
September 26, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679753/cytokine-rich-adipose-tissue-extract-production-from-water-assisted-lipoaspirate-methodology-for-clinical-use
#14
Jenny Lopez, Outi Huttala, Jertta-Riina Sarkanen, Ilkka Kaartinen, Hannu Kuokkanen, Timo Ylikomi
Proper functioning wound healing strategies are sparse. Adequate vascular formation to the injured area, as well as replacement of the volume loss, is fundamental in soft tissue repair. Tissue engineering strategies have been proposed for the treatment of these injury sites. Novel cell-free substance, human adipose tissue extract (ATE), has been previously shown to induce in vitro angiogenesis and adipogenesis and in vivo soft tissue formation. This study reports the translation of ATE preparation from laboratory to the operating room (OR)...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27661288/intimate-partner-violence-is-associated-with-voluntary-sterilization-in-women
#15
Laura Ann McCloskey, Kelly A Doran, Megan R Gerber
BACKGROUND: Intimate partner violence (IPV) may interfere with women's use of preferred forms of contraception, resulting in unwanted pregnancies forcing women to seek permanent sterilization. A history of child sexual abuse (CSA) presages the risk for IPV in adulthood setting the stage for adverse reproductive outcomes. OBJECTIVE: To determine whether CSA and IPV are associated with women's voluntary sterilization when adjusting for demographics and reproductive health history...
September 23, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27647982/fertility-impairment-in-radiotherapy
#16
REVIEW
Marta Biedka, Tamara Kuźba-Kryszak, Tomasz Nowikiewicz, Agnieszka Żyromska
Infertility as a result of antineoplastic therapy is becoming a very important issue due to the growing incidence of neoplastic diseases. Routinely applied antineoplastic treatments and the illness itself lead to fertility disorders. Therapeutic methods used in antineoplastic treatment may cause fertility impairment or sterilization due to permanent damage to reproductive cells. The risk of sterilization depends on the patient's sex, age during therapy, type of neoplasm, radiation dose and treatment area. It is known that chemotherapy and radiotherapy can lead to fertility impairment and the combination of these two gives an additive effect...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27621196/evaluation-of-nickel-allergic-reactions-to-the-essure-micro-insert-theoretical-risk-or-daily-practice
#17
Sara Siemons, Michel Vleugels, Hugo van Eijndhoven
STUDY OBJECTIVE: To evaluate whether de novo development of nickel sensitization is related to placement of the Essure device, and to evaluate whether the grade of reaction to nickel increased after device placement in patients with a confirmed nickel allergy. DESIGN: Prospective cohort study (Canadian Task Force classification II-2). SETTING: Two nonacademic training hospitals in The Netherlands. PATIENTS: Healthy women of childbearing age desiring permanent sterilization...
September 13, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27593410/promotion-of-cells-to-close-gaps-and-encourage-cell-coverage-by-radio-frequency-glow-discharge-treatment
#18
Hanan Ali, Robert E Baier, Rosemary Dziak, Sebastiano Andreana
Exposure of dental abutments to cleaning and sterilizing Radio Frequency Glow Discharge Treatment (RFGDT) triggered greater degrees of human gingival fibroblast (HGF) attachment and spreading over their surfaces. Enhanced cell growth and metabolic activity of such HGFs were found which might lead to improved cellular margins in the smile-revealing "esthetic zone". This investigation, approved by the Institutional Review Board, employed in vitro studies of HGFs to support in vivo clinical applications of differentially treated titanium healing abutments to demonstrate the possible improvements for tissue growth around dental implants...
January 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27569594/does-essure-cause-significant-de-novo-pain-a-retrospective-review-of-indications-for-second-surgeries-following-essure-placement
#19
Huse Kamencic, Luke Thiel, Erwin Karreman, John Thiel
STUDY OBJECTIVES: To examine the surgical indications and pathologic findings in patients undergoing a second surgery following placement of the Essure permanent birth control system to determine the role of Essure in developing new onset pelvic pain. DESIGN: Retrospective cohort (Canadian Task Force classification II-2). SETTING: Tertiary level hospital. PATIENTS: Women who have had Essure placement and subsequent second surgery...
August 25, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27564995/antimicrobial-activity-of-photodynamic-therapy-against-enterococcus-faecalis-before-and-after-reciprocating-instrumentation-in-permanent-molars
#20
Sérgio Luiz Pinheiro, Giuliana Rodrigues Azenha, Yasmin Marialva Democh, Daniela Camila Nunes, Silvia Provasi, Giovana Masiero Fontanetti, Danilo Antônio Duarte, Carlos Eduardo Fontana, Carlos Eduardo da Silveira Bueno
OBJECTIVE: The present study sought to evaluate the antimicrobial activity against Enterococcus faecalis of photodynamic therapy applied before and after reciprocating instrumentation of permanent molars. BACKGROUND: Apical extrusion of debris can cause flare-ups due to introduction of bacteria into the periapical tissues. METHODS: Eighteen mesial roots from permanent mandibular molars were selected. The crowns were removed to obtain a standard root length of 15 mm...
August 25, 2016: Photomedicine and Laser Surgery
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