Charlotte Oris, Alexandre Lautrette, Aurore Dougé, Farouk Bouraima, Samy Kahouadji, Marie-Eva Pickering, Cyril Garrouste, Johan Gagnière, Romain Guièze, Nicolas D'Ostrevy, Emmanuel Futier, Vincent Grobost, Anthony Buisson, Marie Batisse, Jean-Baptiste Bouillon-Minois, Bruno Pereira, Julie Durif, Vincent Sapin, Damien Bouvier
BACKGROUND AND AIMS: To investigate the contribution of FGF23 in explaining the cases of hypophosphatemia observed in clinical practice, we aimed to determine for the first time the prevalence of FGF23 elevation in patients with hypophosphatemia and to describe the different mechanisms of FGF23-related hypophosphatemic disorders. MATERIALS AND METHODS: We performed a prospective, observational, multicenter, cohort study of 260 patients with hypophosphatemia. Blood measurements (PTH, 1,25-dihydroxyvitamin D, bone alkaline phosphatase, 25-hydroxyvitamin D, and FGF23) were performed on a Liaison XL® (DiaSorin) analyzer...
January 13, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry