keyword
https://read.qxmd.com/read/38224930/prevalence-of-fgf23-elevation-in-patients-with-hypophosphatemia
#21
JOURNAL ARTICLE
Charlotte Oris, Alexandre Lautrette, Aurore Dougé, Farouk Bouraima, Samy Kahouadji, Marie-Eva Pickering, Cyril Garrouste, Johan Gagnière, Romain Guièze, Nicolas D'Ostrevy, Emmanuel Futier, Vincent Grobost, Anthony Buisson, Marie Batisse, Jean-Baptiste Bouillon-Minois, Bruno Pereira, Julie Durif, Vincent Sapin, Damien Bouvier
BACKGROUND AND AIMS: To investigate the contribution of FGF23 in explaining the cases of hypophosphatemia observed in clinical practice, we aimed to determine for the first time the prevalence of FGF23 elevation in patients with hypophosphatemia and to describe the different mechanisms of FGF23-related hypophosphatemic disorders. MATERIALS AND METHODS: We performed a prospective, observational, multicenter, cohort study of 260 patients with hypophosphatemia. Blood measurements (PTH, 1,25-dihydroxyvitamin D, bone alkaline phosphatase, 25-hydroxyvitamin D, and FGF23) were performed on a Liaison XL® (DiaSorin) analyzer...
January 13, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38219387/liver-targeted-nanoparticles-delivering-nitric-oxide-reduce-portal-hypertension-in-cirrhotic-rats
#22
JOURNAL ARTICLE
Meritxell Perramón, María Navalón-López, Guillermo Fernández-Varo, Alazne Moreno-Lanceta, Rocío García-Pérez, Joana Faneca, Mario López-Moya, Cristina Fornaguera, Judith García-Villoria, Manuel Morales-Ruiz, Pedro Melgar-Lesmes, Salvador Borrós, Wladimiro Jiménez
Nitric oxide (NO) is a small vasodilator playing a key role in the pathogenesis of portal hypertension. Here, we assessed the potential therapeutic effect of a NO donor targeted to the liver by poly(beta-amino ester) nanoparticles (pBAE NPs) in experimental cirrhosis. Retinol-functionalized NO donor pBAE NPs (Ret pBAE NPs) were synthetized with the aim of actively targeting the liver. Administration of Ret pBAE NPs resulted in uptake and transfection by the liver and spleen. NPs were not found in other organs or the systemic circulation...
January 13, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38204635/outcomes-of-patients-with-advanced-liver-disease-undergoing-cardiac-surgery
#23
JOURNAL ARTICLE
Ingi Pétursson, Andrea Amabile, Ellelan Degife, Alyssa Morrison, Christina Waldron, Syed Usman Bin Mahmood, Sigurður Ragnarsson, Markus Krane, Arnar Geirsson
OBJECTIVE: Liver disease (LD) is considered a risk factor for inferior outcomes in general and cardiac surgery, yet current cardiac surgery risk estimators exclude LD, and literature on the topic remains scant. We sought to evaluate whether the presence of advanced LD is associated with inferior outcomes following cardiac surgery. METHODS: This single-center, retrospective, observational study included 285 patients diagnosed with LD who underwent cardiac surgery in 2010 to 2020...
December 2023: JTCVS open
https://read.qxmd.com/read/38178564/life-threatening-electrical-storm-following-liver-transplantation-a-case-report
#24
JOURNAL ARTICLE
David Richer Araujo Coelho, Rogerio Oliveira da Luz, Samanta Teixeira Basto, Mauro Rogério De Barros Wanderley Júnior, Claudia Cristina Tavares de Sousa, Elke Reis Fagundes de Carvalho, Eduardo de Sousa Martins Fernandes, Anderson Brito-Azevedo
BACKGROUND Electrical storm is a rare but potentially life-threatening syndrome characterized by recurrent ventricular arrhythmias. Liver transplant recipients are at increased risk of developing electrical storms due to conditions that prolong QT intervals, such as cirrhotic cardiomyopathy. However, limited information exists on electrical storms in this specific population. This case report presents a patient who experienced 13 cardiac arrests during ventricular fibrillation following liver transplantation...
January 5, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38172029/perioperative-characteristics-and-outcomes-of-fontan-versus-non-fontan-patients-undergoing-combined-heart-liver-transplantation-a-retrospective-cohort-study
#25
JOURNAL ARTICLE
Wei Kelly Wu, Kara K Siegrist, Ioannis A Ziogas, Kelly L Mishra, Lea K Matsuoka, Jonathan N Menachem, Manhal Izzy, Alexandra Shingina, Nhue L Do, Matthew Bacchetta, Ashish S Shah, Sophoclis P Alexopoulos
OBJECTIVES: Combined heart-liver transplantation (CHLT) is becoming increasingly frequent as a maturing population of patients with Fontan-palliated congenital heart disease develop advanced liver fibrosis or cirrhosis. The authors present their experience with CHLT for congenital and noncongenital indications, and identify characteristics associated with poor outcomes that may guide intervention in high-risk patients. DESIGN: This was a single-center retrospective cohort study...
December 4, 2023: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38158116/cediranib-ameliorates-portal-hypertensive-syndrome-via-inhibition-of-vegfr-2-signaling-in-cirrhotic-rats
#26
JOURNAL ARTICLE
Qiang Fan, Guangbo Wu, Min Chen, Guqing Luo, Zhenghao Wu, Haizhong Huo, Hongjie Li, Lei Zheng, Meng Luo
Portal hypertension (PHT) is a syndrome caused by systemic and portal hemodynamic disturbances with the progression of cirrhosis. However, the exact mechanisms regulating angiogenesis-related responses in PHT remain unclear. Cediranib is a potent inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, exhibiting a greater affinity for VEGFR-2. Liver cirrhosis was induced by common bile duct ligation (BDL) in Sprague-Dawley rats. Sham-operated rats were controls. BDL and sham rats were randomly allocated to receive Cediranib or vehicle after BDL...
December 27, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/38142819/cirrhotic-cardiomyopathy-pathogenesis-clinical-features-diagnosis-treatment-and-prognosis
#27
REVIEW
Francisca Almeida, Alexandra Sousa
Cardiac dysfunction among cirrhotic patients has long been recognized in the medical community. While it was originally believed to be a direct result of alcohol toxicity, in the last 30 years cirrhotic cardiomyopathy (CCM) has been described as a syndrome characterized by chronic cardiac dysfunction in cirrhotic patients in the absence of known cardiac disease, regardless of the etiology of cirrhosis. CCM occurs in about 60% of patients with cirrhosis and plays a critical role in disease progression and treatment outcomes...
December 22, 2023: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://read.qxmd.com/read/38112289/differential-diagnosis-of-ascites-etiologies-ascitic-fluid-analysis-diagnostic-algorithm
#28
REVIEW
Li Du, Ning Wei, Rakhi Maiwall, Yuhu Song
Ascites is the pathological accumulation of fluid within the peritoneal cavity. It often occurs as results of liver cirrhosis, malignant neoplasia, tuberculous infection, cardiac insufficiency, renal diseases, etc. Determining the etiology is an essential step in the management of patients with new-onset ascites. Abdominal paracentesis with appropriate ascitic fluid analysis is probably the most cost-effective method of determining the cause of ascites. We performed a literature search of PubMed and identified articles published in the field of ascites, to evaluate diagnostic values of various parameters in defining the etiologies of ascites and then provides diagnostic algorithm for patients with new-onset ascites...
December 20, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/38109221/utilization-of-aquapheresis-among-hospitalized-patients-with-end-stage-liver-disease-a-case-series-and-literature-review
#29
REVIEW
James F Crismale, Tonia Kim, Thomas D Schiano
Third-spacing of fluid is a common complication in hospitalized patients with decompensated cirrhosis. In addition to ascites, patients with advanced cirrhosis may develop significant peripheral edema, which may limit mobility and exacerbate debility and muscle wasting. Concomitant kidney failure and cardiac dysfunction may lead to worsening hypervolemia, which may ultimately result in pulmonary edema and respiratory compromise. Diuretic use in such patients may be limited by kidney dysfunction and electrolyte abnormalities, including hyponatremia and hypokalemia...
January 2024: Clinical Transplantation
https://read.qxmd.com/read/38093277/incident-cardiac-arrhythmias-associated-with-metabolic-dysfunction-associated-steatotic-liver-disease-a-nationwide-histology-cohort-study
#30
JOURNAL ARTICLE
Tracey G Simon, Fahim Ebrahimi, Bjorn Roelstraete, Hannes Hagström, Johan Sundström, Jonas F Ludvigsson
BACKGROUND: Prior studies suggest a link between metabolic dysfunction-associated steatotic liver disease (MASLD) and incident arrhythmias, including atrial fibrillation (AF). However, robust data are lacking from cohorts with liver histology, which remains the gold standard for staging MASLD severity. METHODS: This population-based cohort included all Swedish adults with histologically-confirmed MASLD and without prior cardiac arrhythmias (1966-2016; n = 11,206)...
December 13, 2023: Cardiovascular Diabetology
https://read.qxmd.com/read/38089549/cardiomyopathy-in-cirrhosis-from-pathophysiology-to-clinical-care
#31
REVIEW
Hongqun Liu, Jwan A Naser, Grace Lin, Samuel S Lee
Cirrhotic cardiomyopathy (CCM) is defined as systolic or diastolic dysfunction in the absence of prior heart disease or another identifiable cause in patients with cirrhosis, in whom it is an important determinant of outcome. Its underlying pathogenic/pathophysiological mechanisms are rooted in two distinct pathways: 1) factors associated with portal hypertension, hyperdynamic circulation, gut bacterial/endotoxin translocation and the resultant inflammatory phenotype; 2) hepatocellular insufficiency with altered synthesis or metabolism of substances such as proteins, lipids, carbohydrates, bile acids and hormones...
January 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38057975/-profuse-hemorage-during-open-heart-surgery-in-a-patient-late-after-liver-transplantation-and-remission-stage-acquired-hemophilia
#32
JOURNAL ARTICLE
Yasuhito Nakamura, Yoshitaka Kumada, Norikazu Kawai, Narihiro Ishida
A 72-year-old male presented with severe mitral regurgitation, moderate tricuspid regurgitation, and chronic atrial fibrillation. One month prior, he encountered difficulties with dialysis and was subsequently referred to our department for cardiac surgery. The patient's medical history includes living-donor liver transplantation for type C cirrhosis associated with acquired hemophilia A. The preoperative liver function was categorized as Child-Pugh grade B, with a model for end-stage liver disease( MELD) score of 23...
November 2023: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/38050733/combined-liver-transplant-and-cardiac-surgery-long-term-outcomes-and-predictors-of-success
#33
JOURNAL ARTICLE
Chase J Wehrle, Andrea Schlegel, Mazhar Khalil, Daniel Rotroff, Luca Del Prete, Marianna Maspero, Roma Raj, William C Frankel, Bijan Eghtesad, Federico Aucejo, Masato Fujiki, Choon David Kwon, Jaekeun Kim, Michael Z Y Tong, Shinya Unai, Jacek Cywinski, Jamak Modaresi Esfeh, Maan Fares, Alejandro Pita, Charles Miller, Cristiano Quintini, Koji Hashimoto, Teresa Diago-Uso
OBJECTIVE: We aim to report our institutional outcomes of single-staged combined liver transplantation (LT) and cardiac surgery (CS). SUMMARY BACKGROUND DATA: Concurrent LT and CS is a potential treatment for combined cardiac dysfunction and end-stage liver disease, yet only 54 cases have been previously reported in the literature. Thus, the outcomes of this approach are relatively unknown, and this approach has been previously regarded as extremely risky. METHODS: Thirty-one patients at our institution underwent combined cardiac surgery and liver transplant...
December 5, 2023: Annals of Surgery
https://read.qxmd.com/read/38046233/-imagen-multimodal-de-la-pericarditis-constrictiva-reporte-de-un-caso-de-cirrosis-cardiaca
#34
Lucía Barriales-Revilla, Lindsay Benites-Yshpilco, Roberto Baltodano-Arellano, Luis Falcón-Quispe, Kelly Cupe-Chacalcaje, Angela Cachicatari-Beltrán, Gerald Lévano-Pachas
Constrictive pericarditis is a rare cause of ascites and cardiac cirrhosis. We present the case of a 36-year-old male patient with a history of cirrhosis of unknown etiology, who consulted for refractory ascites, dyspnea, and lower limb swelling. Echocardiography determined constrictive pericarditis, which was corroborated by the findings of computed tomography. The clinical and hemodynamic worsening of the patient led to an emergency pericardiectomy with satisfactory recovery. This report shows a severe clinical consequence of constrictive pericarditis, cardiac cirrhosis, which was reversible with pericardial extirpation...
2023: Arch Peru Cardiol Cir Cardiovasc
https://read.qxmd.com/read/38041421/a-comparison-between-patients-with-various-etiologies-of-cirrhosis-and-examination-of-cardiac-risk-factors-limiting-survival-to-liver-transplantation
#35
JOURNAL ARTICLE
Michael J Delicce, Joseph Mauch, Omar T Sims, Ruishen Lyu, Heather Kren, Rose Bartow, Donna Ferchill, Abel Joseph, Maan Fares, Jamile Wakim-Fleming
BACKGROUND & AIMS: Objectives of this retrospective cohort study were to assess differences in patient survival between etiologies of cirrhosis while on the waitlist for liver transplantation (LT), and to identify cardiac risk factors that predict survival failure while on the waitlist for LT. METHODS: This single-center retrospective cohort design included adult patients who were listed for LT at a tertiary academic hospital with a high-volume liver transplant center...
December 1, 2023: Clinical Transplantation
https://read.qxmd.com/read/38014628/liver-stiffness-as-a-cornerstone-in-heart-disease-risk-assessment
#36
REVIEW
Joost Boeckmans, Laurent Sandrin, Christian Knackstedt, Jörn M Schattenberg
Metabolic dysfunction-associated steatotic liver disease (MASLD) typically presents with hepatic fibrosis in advanced disease, resulting in increased liver stiffness. A subset of patients further develops liver cirrhosis and hepatocellular carcinoma. Cardiovascular disease is a common comorbidity in patients with MASLD and its prevalence is increasing in parallel. Recent evidence suggests that especially liver stiffness, whether or not existing against a background of MASLD, is associated with heart diseases...
November 28, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/37988070/using-noninvasive-clinical-parameters-to-predict-mortality-and-morbidity-after-cardiac-interventions-in-patients-with-cirrhosis-a-systematic-review
#37
JOURNAL ARTICLE
Christo Mathew, Ankur Patel, George Cholankeril, Avegail Flores, Ruben Hernaez
BACKGROUND: Cardiovascular disease commonly affects advanced liver disease patients. They undergo cardiac interventions to improve cardiac outcomes. Cirrhosis increases complication risk, including bleeding, renal and respiratory failure, and further decompensation, including death, posing a clinical dilemma to proceduralists. Predicting outcomes is crucial in managing patients with cirrhosis. Our aim was to systematically review clinical parameters to assess the mortality and complication risk in patients with cirrhosis undergoing cardiac interventions...
January 1, 2024: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://read.qxmd.com/read/37970569/association-between-alcohol-associated-cirrhosis-and-inpatient-complications-among-covid-19-patients-a-propensity-matched-analysis-from-the-united-states
#38
JOURNAL ARTICLE
Faisal Inayat, Hassam Ali, Pratik Patel, Rubaid Dhillon, Arslan Afzal, Attiq Ur Rehman, Muhammad Sohaib Afzal, Laraib Zulfiqar, Gul Nawaz, Muhammad Hassan Naeem Goraya, Subanandhini Subramanium, Saurabh Agrawal, Sanjaya K Satapathy
BACKGROUND: Alcohol-associated cirrhosis (AC) contributes to significant liver-related mortality in the United States. It is known to cause immune dysfunction and coagulation abnormalities. Patients with comorbid conditions like AC are at risk of worse clinical outcomes from coronavirus disease 2019 (COVID-19). The specific association between AC and COVID-19 mortality remains inconclusive, given the lack of robust clinical evidence from prior studies. AIM: To study the predictors of mortality and the outcomes of AC in patients hospitalized with COVID-19 in the United States...
September 25, 2023: World Journal of Virology
https://read.qxmd.com/read/37966270/mitochondrial-dysfunction-is-associated-with-the-severity-of-liver-fibrosis-in-patients-after-the-fontan-operation
#39
JOURNAL ARTICLE
Saviga Sethasathien, Krit Leemasawat, Suchaya Silvilairat, Rekwan Sittiwangkul, Krit Makonkawkeyoon, Apinya Leerapun, Sarawut Kongkarnka, Nakarin Inmutto, Supanai Suksai, Nattayaporn Apaijai, Siriporn C Chattipakorn, Nipon Chattipakorn
The gold standard for determining the severity of liver disease in Fontan patients is now liver biopsy. Since it is an invasive procedure, this study determined the possibility of applying mitochondrial function from isolated peripheral blood mononuclear cells (PBMCs) as a non-invasive indicator of liver fibrosis. Fontan patients (n = 37) without known liver disease were analysed cross-sectionally. Patients were classified according to their histology using the METAVIR score as follows; F0/F1-no/mild fibrosis; F2-moderate fibrosis; and F3/F4-cirrhosis...
November 15, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/37959225/transjugular-intrahepatic-portosystemic-shunt-devices-evolution-technical-tips-and-future-perspectives
#40
REVIEW
Dario Saltini, Federica Indulti, Tomas Guasconi, Marcello Bianchini, Biagio Cuffari, Cristian Caporali, Federico Casari, Francesco Prampolini, Marco Senzolo, Antonio Colecchia, Filippo Schepis
Portal hypertension (PH) constitutes a pivotal factor in the progression of cirrhosis, giving rise to severe complications and a diminished survival rate. The transjugular intrahepatic portosystemic shunt (TIPS) procedure has undergone significant evolution, with advancements in stent technology assuming a central role in managing PH-related complications. This review aims to outline the progression of TIPS and emphasizes the significant influence of stent advancement on its effectiveness. Initially, the use of bare metal stents (BMSs) was limited due to frequent dysfunction...
October 25, 2023: Journal of Clinical Medicine
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