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Cardiac cirrhosis

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https://www.readbyqxmd.com/read/29118563/cardiac-dysfunction-as-an-early-predictor-of-portal-hypertension-in-chronic-hepatitis-c
#1
Cecilia Marconi, Mattia Bellan, Paola Giarda, Rosalba Minisini, Serena Favretto, Michela Emma Burlone, Lisa Franzosi, Mario Pirisi
Background: Cirrhotic cardiomyopathy is characterized by a set of cardiovascular modifications observed in advanced chronic liver disease. The aim of this study was to investigate cardiovascular alterations in chronic liver disease with different stages of fibrosis and to correlate cardiac involvement with endoscopic complications of portal hypertension. Methods: Seventy patients with chronic hepatitis C-related chronic liver disease and 20 sex- and age-matched controls underwent clinical evaluation, hepatic transient elastography, and echocardiography...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29077655/contemporary-outcomes-of-combined-heart-liver-transplant-in-patients-with-congenital-heart-disease
#2
Roosevelt Bryant, Raheel Rizwan, Farhan Zafar, Shimul A Shah, Clifford Chin, James Tweddell, David L S Morales
BACKGROUND: As more patients survive into adulthood with repaired congenital heart disease (CHD), transplant centers now have patients presenting with both end stage cardiac and hepatic failure. An understanding of the contemporary outcomes with combined heart liver transplantation (CHLT) in patients with CHD is needed. METHODS: A retrospective review of the outcomes of CHLT in CHD was conducted from 10/1/87 to 6/30/15 from United Network of Organ Sharing (UNOS) database...
October 26, 2017: Transplantation
https://www.readbyqxmd.com/read/29074483/transjugular-intrahepatic-portosystemic-shunt-impact-on-systemic-haemodynamics-and-renal-and-cardiac-function-in-patients-with-cirrhosis
#3
Troels Malte Busk, Flemming Bendtsen, Jørgen Hjelm Poulsen, Jens Otto Clemmesen, Fin Stolze Larsen, Jens Peter Goetze, Jens Schmidt Iversen, Magnus Thorsten Jensen, Rasmus Møgelvang, Erling Bjerregaard Pedersen, Jesper Noergaard Bech, Søren Møller
BACKGROUND AND AIMS: Transjugular intrahepatic portosystemic shunt (TIPS) alleviates portal hypertension and possibly increases central blood volume (CBV). Moreover, renal function often improves; however, its effects on cardiac function are unclear. The aims of our study were to examine the effects of TIPS on hemodynamics and renal and cardiac function in patients with cirrhosis. METHODS: In 25 cirrhotic patients, we analyzed systemic, cardiac, and splanchnic hemodynamics by catheterization of the liver veins and right heart chambers before and 1 week after TIPS...
October 26, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29065699/annals-express-performance-of-autotaxin-as-a-serum-marker-of-liver-fibrosis
#4
Hitoshi Ikeda, Mariko Kobayashi, Hiromitsu Kumada, Kenichiro Enooku, Kazuhiko Koike, Makoto Kurano, Masaya Sato, Takahiro Nojiri, Tamaki Kobayashi, Ryunosuke Ohkawa, Satoshi Shimamoto, Koji Igarashi, Junken Aoki, Yutaka Yatomi
BACKGROUND: Because autotaxin (ATX) reportedly has a better performance than hyaluronic acid (HA) as a marker of liver fibrosis for the prediction of cirrhosis caused by hepatitis C, we aimed to further evaluate the role of ATX in liver fibrosis of other etiologies. METHODS: ATX antigen was measured in serum samples from 108 patients with chronic hepatitis B and 128 patients with non-alcoholic fatty liver disease (NAFLD) who had undergone a liver biopsy as well as healthy subjects and patients with chronic kidney disease (CKD), diabetes mellitus (DM), rheumatoid arthritis (RA) and cardiac dysfunction (CD)...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29059861/modeling-young-and-adult-patients-with-cirrhosis-through-a-three-element-windkessel-wk3e
#5
L J Cymberknop, I Farro, C R Arbeitman, J Cardelino, R L Armentano
INTRODUCTION: Measurement of hemodynamic parameters constitutes an important tool in the management of patients with cirrhosis. In recent years, non-invasive measurements have gain attention, due to the potential complications associated to invasive procedures. OBJECTIVE: To characterize the hemodynamic alterations of cirrhosis in young and adult subjects, through a three element windkessel (WK3e). METHODS: Individuals were divided in three age groups: Young Healthy group (control, CG), Young Cirrhotic Group (YCG) and Adult Cirrhotic Group (ACG)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054902/chylous-ascites-in-a-patient-with-an-overlap-syndrome-a-surprising-response-to-rituximab
#6
Alexandra Daniel, Gianluca Bagnato, Edward Vital, Francesco Del Galdo
The authors present a case of a 51-year-old woman with clinical diagnosis of mixed connective tissue disease and overlap systemic lupus erythematosus features, with a 6-month history of progressive painless abdominal distension. On examination, evident signs of ascites were present. Both the abdominal-pelvic ultrasound and CT scan confirmed a large amount of ascites. A diagnostic paracentesis was performed, which revealed typical features of chylous ascites (CA). An extensive diagnostic work-up led by a multidisciplinary team was performed, excluding malignancy, cirrhosis, infectious, as well as cardiac and primary lymphatic causes...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29027095/multimodality-imaging-of-pericardial-diseases
#7
REVIEW
Mouaz H Al-Mallah, Fatimah Almasoudi, Mohamed Ebid, Amjad M Ahmed, Abdelrahman Jamiel
Pericardial diseases have changed their epidemiology in the past few years. With the aging population and decreasing incidence of communicable diseases, the causes of pericardial diseases have significantly changed from infectious and malignant to postradiation and cardiac surgery causes. Despite that, pericardial diseases remain difficult to diagnose. The accurate and timely diagnosis of these diseases is essential to avoid the late sequela of pericardial constriction and pericardial cirrhosis. Echocardiography remains the first test of choice for the assessment of patients with suspected pericardial diseases...
October 12, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28986855/outcome-of-in-and-out-of-hospital-cardiac-arrest-survivors-with-liver-cirrhosis
#8
Kevin Roedl, Christian Wallmüller, Andreas Drolz, Thomas Horvatits, Karoline Rutter, Alexander Spiel, Julia Ortbauer, Peter Stratil, Pia Hubner, Christoph Weiser, Jasmin Katrin Motaabbed, Dominik Jarczak, Harald Herkner, Fritz Sterz, Valentin Fuhrmann
BACKGROUND: Organ failure increases mortality in patients with liver cirrhosis. Data about resuscitated cardiac arrest patients with liver cirrhosis are missing. This study aims to assess aetiology, survival and functional outcome in patients after successful cardiopulmonary resuscitation (CPR) with and without liver cirrhosis. METHODS: Analysis of prospectively collected cardiac arrest registry data of consecutively hospital-admitted patients following successful CPR was performed...
October 6, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28985025/multidisciplinary-approach-to-cardiac-and-pulmonary-vascular-disease-risk-assessment-in-liver-transplantation-an-evaluation-of-the-evidence-and-consensus-recommendations
#9
Lisa B VanWagner, Matthew E Harinstein, James R Runo, Christopher Darling, Marina Serper, Shelley Hall, Jon A Kobashigawa, Laura L Hammel
Liver transplant (LT) candidates today are older, have greater medical severity of illness, and have more cardiovascular comorbidities than ever before. In addition, there are specific cardiovascular responses in cirrhosis that can be detrimental to the LT candidate. Cirrhotic cardiomyopathy, a condition characterized by increased cardiac output and a reduced ventricular response to stress, is present in up to 30% of patients with cirrhosis thus challenging perioperative management. Current noninvasive tests that assess for subclinical coronary and myocardial disease have low sensitivity, and altered hemodynamics during the LT surgery can unmask latent cardiovascular disease either intraoperatively or in the immediate postoperative period...
October 6, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28953449/hepatitis-c-virus-associated-extrahepatic-manifestations-in-lung-and-heart-and-antiviral-therapy-related-cardiopulmonary-toxicity
#10
Syeda Zainab Ilyas, Rabia Tabassum, Haroon Hamed, Shafiq Ur Rehman, Ishtiaq Qadri
Besides liver cirrhosis and hepatocellular carcinoma, chronic hepatitis C virus (HCV) infection is associated with many extrahepatic manifestations (EHMs). HCV exhibits lymphotropism that is responsible for various EHM. An important characteristic of HCV is escape from the immune system, which enables it to produce chronic infections and autoimmune disorders along with accumulation of circulating immune complexes. These EHMs have large spectrum, because they affect many organs such as heart, lungs, kidney, brain, thyroid, and skin...
November 2017: Viral Immunology
https://www.readbyqxmd.com/read/28947309/wilson-s-disease-and-cardiac-myopathy
#11
Donald J Grandis, Gregory Nah, Isaac R Whitman, Eric Vittinghoff, Thomas A Dewland, Jeffrey E Olgin, Gregory M Marcus
Wilson's disease is a well-characterized disorder known to cause liver and brain disease due to abnormal copper deposition. Data regarding copper infiltration of the heart is conflicting, and the risk of heart disease has not been well described. We aimed to determine whether Wilson's disease is associated with cardiac myopathy, clinically evident in the atria as atrial fibrillation (AF) and in the ventricles as heart failure (HF). We longitudinally assessed 14.3 million patients in the California Healthcare Cost and Utilization Project database from 2005 through 2009 for diagnoses of Wilson's disease, AF, HF, and covariates using International Classification of Diseases-9th Edition codes...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28923628/role-of-coronary-angiography-in-pre-liver-transplantation-cardiac-evaluation-experience-from-an-asian-transplant-institution
#12
N Q Pang, W C A Kow, J H Law, L T T Pan, B L K Lim, C C R Wong, K Y S Chang, I S Ganpathi, K Madhavan
BACKGROUND: Liver transplant (LT) patients with significant coronary artery disease (CAD) have poorer outcomes. Pre-LT coronary angiography (CA) is associated with significant complications in cirrhotic patients. METHODS: This study aimed to identify predictors of abnormal CA in pre-LT cardiac assessment and to develop a predictive model to reduce unnecessary CA. From January 2006 to June 2013, 122 patients underwent CA based on the current institutional protocol...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28902431/cardiovascular-predictors-of-death-in-patients-with-cirrhosis
#13
Maurizio Cesari, Anna Chiara Frigo, Marta Tonon, Paolo Angeli
Cirrhotic cardiomyopathy is associated with poor outcomes in patients with cirrhosis. We investigated if subclinical cardiac morphologic and functional modifications can influence survival in cirrhotic patients during follow-up. A series of cirrhotic patients without cardiovascular or pulmonary disease underwent standard and tissue Doppler echocardiography to assess left ventricular (LV) geometry, systo/diastolic function and the main haemodynamic parameters. After baseline evaluation 115 cirrhotic patients were followed up for at least 6 years...
September 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28893408/inflammatory-myopathy-associated-with-antimitochondrial-antibodies-a-distinct-phenotype-with-cardiac-involvement
#14
Jemima Albayda, Aamna Khan, Livia Casciola-Rosen, Andrea M Corse, Julie J Paik, Lisa Christopher-Stine
OBJECTIVE: In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac disease in myositis patients with antimitochondrial antibodies. We sought to review all cases of antimitochondrial antibody (AMA) associated myositis in our cohort to describe the clinical features of this disease subset. METHODS: We identified 7 patients with confirmed antimitochondrial antibodies who presented as an inflammatory myopathy...
June 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28864370/pro-brain-natriuretic-peptide-and-troponin-t-hypersensitivity-levels-correlate-with-the-severity-of-liver-dysfunction-in-liver-cirrhosis
#15
Jiancheng Zhao, Sai Li, Linan Ren, Xiaozhong Guo, Xingshun Qi
BACKGROUND: Increased pro-brain natriuretic peptide (pro-BNP) or troponin T-hypersensitivity (TnT-HSST) levels are common in liver cirrhosis. We conducted a retrospective observational study aimed to evaluate the correlation of pro-BNP and TnT-HSST levels with the clinical characteristics, laboratory data and in-hospital outcomes of patients with liver cirrhosis. MATERIALS AND METHODS: We selected cirrhotic patients admitted to our hospital between January 2011 and June 2014...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28840954/assessing-the-kinetics-of-microbubble-appearance-in-cirrhotic-patients-using-transthoracic-saline-contrast-enhanced-echocardiography
#16
Adriano R Tonelli, Tawfeq Naal, Wael Dakkak, Margaret M Park, Raed A Dweik, James K Stoller
BACKGROUND: The number of cardiac cycles that need to be reviewed by echocardiography before a significant intrapulmonary shunt can be excluded remains unclear. METHODS: We retrospectively identified patients with cirrhosis who underwent technetium-99 m-labeled macroaggregated albumin scanning. The kinetics of bubble appearance after the injection of agitated saline during transthoracic echocardiograms were assessed in these patients. RESULTS: For the 64 eligible patients, the mean ± SD age was 56 ± 9 years...
October 2017: Echocardiography
https://www.readbyqxmd.com/read/28840045/hemoperitoneum-secondary-to-spontaneous-rupture-of-a-retroperitoneal-varix
#17
Derrick D Eichele
Hemoperitoneum due to a ruptured retroperitoneal varix is an exceedingly rare condition and a poor prognostic sign with catastrophic and life-threatening complication of portal hypertension. We present a unique case of a 56-year-old female with cirrhosis secondary to primary sclerosing cholangitis who presented with acute abdominal pain and hypovolemic shock prior to a cardiac arrest following a ruptured retroperitoneal varix without prior esophageal varices and a newly identified intrahepatic cholangiocarcinoma...
2017: Case Reports in Hepatology
https://www.readbyqxmd.com/read/28836926/platypnoea-orthodeoxia-syndrome-in-the-elderly-a-difficult-to-make-diagnosis-of-intracardiac-right-to-left-shunt
#18
Enrico M Zardi, Silvia Spoto, Luciana Locorriere, Giulio Cacioli, Silvia Mazzaroppi, Bruno B Zobel, Germano Di Sciascio, Sebastiano Costantino
Introduction Platypnea-orthodeoxia syndrome is a combination of positional dyspnoea and hypoxemia; it is caused by several cardiac, pulmonary and hepatic diseases. Case presentation In this study, we describe a 77-year-old female affected by unexplained dizziness and hypoxia that exacerbated in upright position. After diagnosing platypnea-orthodeoxia syndrome and excluding all possible causes (liver cirrhosis, acute and chronic pulmonary diseases and arteriovenous malformations), the origin of the syndrome was individuated in the presence of a patent foramen ovale with right-to-left shunt...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28812111/syndrome-of-inappropriate-anti-diuresis-induces-volume-dependent-hypercalciuria
#19
J Grellier, A Jaafar, A Martin, M El Alaoui, C Lebely, I Tack, M Vallet
Hyponatremia is associated with bone demineralization. We hypothesized that, during hyponatremia, calciuria and calcium balance depend on volemic status. We evaluated calciuria in patients with hyponatremia, secondary to SIAD or hypovolemia. Patients with SIAD exhibited a volemic expansion that was associated with hypercalciuria. Calciuria was proportional to markers of volemia. INTRODUCTION: Chronic mild hyponatremia has been associated with bone demineralization of unknown mechanisms...
November 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28806738/partial-igf-1-deficiency-is-sufficient-to-reduce-heart-contractibility-angiotensin-ii-sensibility-and-alter-gene-expression-of-structural-and-functional-cardiac-proteins
#20
José Luis González-Guerra, Inma Castilla-Cortazar, Gabriel A Aguirre, Úrsula Muñoz, Irene Martín-Estal, Elena Ávila-Gallego, Miriam Granado, Juan E Puche, Ángel Luis García-Villalón
Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with insulin resistance, dyslipidemia, progression to type 2 diabetes, and increased risk for cardiovascular diseases. However, underlying mechanisms between IGF-1 deficiency and cardiovascular disease remain elusive. The specific aim of the present work was to study whether the partial IGF-1 deficiency influences heart and/or coronary circulation, comparing vasoactive factors before and after of ischemia-reperfusion (I/R)...
2017: PloS One
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