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Cardiac cirrhosis

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https://www.readbyqxmd.com/read/28706863/non-functional-tricuspid-valve-disease
#1
REVIEW
Dale S Adler
Only 75% of severe tricuspid regurgitation is classified as functional, or related primarily to pulmonary hypertension, right ventricular dysfunction, or a combination of both. Non-functional tricuspid regurgitation occurs when there is damage to the tricuspid leaflets, chordae, papillary muscles, or annulus, independent of right ventricular dysfunction or pulmonary hypertension. The entities that cause non-functional tricuspid regurgitation include rheumatic and myxomatous disease, acquired and genetic connective tissue disorders, endocarditis, sarcoid, pacing, RV biopsy, blunt trauma, radiation, carcinoid, ergot alkaloids, dopamine agonists, fenfluramine, cardiac tumors, atrial fibrillation, and congenital malformations...
May 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28694703/secondary-sclerosing-cholangitis-in-critically-ill-patients-current-perspectives
#2
REVIEW
Hafsteinn O Gudnason, Einar S Björnsson
Secondary sclerosing cholangitis (SSC) is a term used for a group of chronic cholestatic disease affecting the intra- and/or extrahepatic biliary tree with inflammation and progressive stricture formation, which can lead to biliary cirrhosis. A newly recognized form of SSC is secondary sclerosing cholangitis in critically ill patients (SSC-CIP). Pathogenesis is believed to involve ischemic injury of intrahepatic bile ducts associated with prolonged hypotension, vasopressors administration, and/or mechanical ventilation in patients treated in the intensive care unit (ICU)...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28693742/impact-of-cirrhosis-in-patients-who-underwent-surgical-aortic-valve-replacement
#3
Robert J Steffen, Faisal G Bakaeen, Patrick R Vargo, Bogdan A Kindzelski, Douglas R Johnston, Eric E Roselli, A Marc Gillinov, Lars G Svensson, Edward G Soltesz
Cirrhosis is known to adversely affect cardiac surgery outcomes. Our objective was to quantify the morbidity, mortality, and cost that cirrhosis adds to surgical aortic valve replacement. From 1998 to 2011, 423,789 patients in the Nationwide Inpatient Sample Healthcare Cost Utilization Project underwent isolated aortic valve replacement; 2,769 (0.7%) had cirrhosis. Multivariable linear regression and 1:1 propensity matching were used to determine the effect of cirrhosis on postsurgical outcomes. The number of patients with cirrhosis who underwent surgical aortic valve replacement per year more than tripled during the 13-year study period...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28680841/hepatic-encephalopathy-in-liver-cirrhosis
#4
Herbert Djiambou-Nganjeu
Liver cirrhosis is a worldwide gastroenterological condition, characterized by a slow, progressive and irreversible replacement of liver cells by fibrous tissue (scar) that prevents liver function. This condition often leads to the development of other syndromes. Cardiac complications can be indicated through abnormal QTc interval and arrhythmias, thereby their analysis aids in the prevention of cardiovascular events. Most cirrhotic cases have abnormal laboratory values (bilirubin, albumin, AST, ALT, AST/ALT, INR) indicating the presence of concomitant infection, inflammation and coagulopathy...
March 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28663674/fas-receptor-activation-by-endogenous-opioids-is-a-new-mechanism-for-cardiomyopathy-in-cirrhotic-rats
#5
Ata Abbasi, Negar Faramarzi, Mohsen Khosravi, Fatemeh Yazarloo, Mohammad Amin Abbasi, Ahmad R Dehpour, Issa Jahanzad
BACKGROUND: Cirrhosis, a common consequence of chronic liver inflammation is associated with various cardiovascular dysfunctions which are called cirrhotic cardiomyopathy (CC). Among the various possible causes of CC, apoptosis is considered to have a pivotal role. OBJECTIVES: To explore the contribution of endogenous opioids in the apoptosis process in a rat model of CC. MATERIAL AND METHODS: Four genes were selected to cover both intrinsic and extrinsic pathways of apoptosis...
June 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28657113/high-burden-of-coronary-atherosclerosis-in-patients-with-cirrhosis
#6
Konstantin Kazankov, Kim Munk, Kristian Altern Øvrehus, Jesper Møller Jensen, Cecilie Brøckner Siggaard, Henning Grønbaek, Bjarne Linde Nørgaard, Hendrik Vilstrup
BACKGROUND: Population studies report increased cardiovascular mortality in patients with cirrhosis. Coronary artery disease may be a trait of end-stage liver disease, but whether it is frequent or extensive in cirrhosis in general is unknown. Thus, we aimed to assess the prevalence and extent of coronary artery disease in unselected cirrhosis patients. MATERIALS AND METHODS: Using coronary computed tomography angiography, we investigated 52 patients from all Child-Pugh classes and etiologies of cirrhosis without known cardiac disease for presence and severity of coronary artery disease in a cross-sectional design...
June 28, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28602970/increased-risk-of-death-in-the-hospital-and-outside-the-intensive-care-unit-for-patients-with-cirrhosis-after-cardiac-arrest
#7
Megan E Reinders, Gabriel Wardi, Ricki Bettencourt, Daniel Bouland, Jessica Bazick, Michel Mendler, Irine Vodkin, Denise Kalmaz, Thomas Savides, David Brenner, Rebecca E Sell, Rohit Loomba
No abstract text is available yet for this article.
June 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28602892/cell-based-therapy-using-umbilical-cord-blood-for-novel-indications-in-regenerative-therapy-and-immune-modulation-an-updated-systematic-scoping-review-of-the-literature
#8
REVIEW
Mina Rizk, Joseph Aziz, Risa Shorr, David S Allan
Cell-based therapy using umbilical cord blood (UCB) is being used increasingly in novel applications. To balance heightened public expectations and ensure appropriateness of emerging cell-based treatment choices, regular evidence-based assessment of novel UCB-derived therapies is needed. We performed a systematic search of the literature and identified 57 studies (814 patients) for analysis. Sixteen of these studies (353 patients) included a control group for comparison. The most commonly reported novel indication for therapy was neurologic diseases (25 studies, 476 patients), including studies of cerebral palsy (12 studies, 276 patients)...
June 30, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28586578/electrophysiological-changes-in-patients-with-liver-cirrhosis-in-a-tertiary-care-hospital-in-karachi-pakistan
#9
Om Parkash, Ghulam Rehman Mohyuddin, Adil Ayub, Irfan Nazir, Arslan Arif Maan, Saeed Hamid
BACKGROUND: Electrophysiological changes in cirrhosis are well known but least investigated especially in our country hence we wanted to see electrophysiological changes especially QT interval in cirrhotic patients. METHODS: A cross-sectional study was conducted at Aga Khan University Hospital Karachi (AKUH) in which medical records (duration 2008-2010) of cirrhotic patients were reviewed. RESULTS: Three hundred and eighty cirrhotic patients' charts were studied, 227 (59...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28583534/pretransplant-resting-heart-rate-and-its-association-with-all-cause-mortality-in-liver-transplant-recipients
#10
H-M Kwon, I-G Jun, K-W Jung, Y-J Moon, W-J Shin, J-G Song, G-S Hwang
BACKGROUND: The importance of heart rate (HR) measurement as a prognostic factor has been recognized in many clinical conditions, such as hypertension, coronary artery disease, or heart failure. Patients with liver cirrhosis tend to have increased resting HR as consequence of hyperdynamic circulation. In the current study, we examined whether pretransplant resting increased HR is associated with overall mortality in cirrhotic patients following liver transplantation (LT). PATIENTS AND METHODS: We retrospectively collected and analyzed the data of 881 liver recipients who underwent LT surgery between October 2009 and September 2012...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28577851/impact-of-liver-indicators-on-clinical-outcome-in-patients-undergoing-transcatheter-aortic-valve-implantation
#11
Daniel Wendt, Philipp Kahlert, Ali Canbay, Stephan Knipp, Martin Thoenes, Gordina Cremer, Fadi Al-Rashid, Rolf-Alexander Jánosi, Karim El-Chilali, Markus Kamler, Mohamed El Gabry, Philipp Marx, Daniel Sebastian Dohle, Konstantinos Tsagakis, Jaroslav Benedik, Guido Gerken, Tienush Rassaf, Heinz Jakob, Matthias Thielmann
BACKGROUND: Liver dysfunction increases death and morbidity after cardiac operations. There are currently no data evaluating liver function in patients undergoing transcatheter aortic valve replacement (TAVR). We aimed therefore to evaluate our TAVR results in regard to liver function. METHODS: A total of 640 consecutive TAVR patients were evaluated. Of those, 11 patients presented with chronic liver disease before TAVR. The Model for End-Stage Liver Disease score was used to measure liver function in these patients...
June 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28559699/pulmonary-hypertension-in-patients-with-hepatic-cirrhosis-and-portal-hypertension-an-echographic-study
#12
Adriana V Gurghean, Ioana A Tudor
AIM OF THE STUDY: The aim of the study is to determine the frequency of pulmonary hypertension in patients with hepatic cirrhosis and portal hypertension, to determine the possibility of an accurate ultrasound diagnosis of the characteristics of this complication. METHOD: 347 patients with liver cirrhosis consecutively hospitalized at Coltea Clinical Hospital were screened. 61 were excluded because of other possible causes of portal or pulmonary hypertension. All patients were investigated clinically and by abdominal and cardiac ultrasonography...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28554673/secondary-sclerosing-cholangitis-in-cardiac-surgical-patients-a-complication-with-a-dismal-prognosis
#13
Ina Schade, Dejan Radakovic, Jörg Hoffmann, Sebastian-Patrick Sommer, Ullrich Stefenelli, Christoph Schimmer, Rainer G Leyh, Ivan Aleksic
OBJECTIVES: Secondary sclerosing cholangitis in critically ill patients is a rapidly progressing disease leading to biliary fibrosis and cirrhosis. We describe the course of sclerosing cholangitis in critically ill patients after cardiac surgery and compare this with matched patients. METHODS: A retrospective search for "secondary sclerosing cholangitis" and "liver and/or hepatic failure" in all adult patients (aged 18-93 years) who underwent cardiac surgery from April 2007 to March 2016 identified 192 of 8625 patients...
April 27, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28533908/ascites-refractory-ascites-and-hyponatremia-in-cirrhosis
#14
Brett Fortune, Andres Cardenas
Ascites is the most common complication related to cirrhosis and is associated with increased morbidity and mortality. Ascites is a consequence of the loss of compensatory mechanisms to maintain the overall effective arterial blood volume due to worsening splanchnic arterial vasodilation as a result of clinically significant portal hypertension. In order to maintain effective arterial blood volume, vasoconstrictor and antinatriuretic pathways are activated, which increase overall sodium and fluid retention...
May 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/28515029/tolvaptan-utilization-in-children-with-chronic-hyponatremia-due-to-inappropriate-antidiuretic-hormone-secretion-siadh-three-case-reports-and-review-of-the-literature
#15
Gerdi Tuli, Daniele Tessaris, Luisa De Sanctis, Patrizia Matarazzo
Hyponatremia is the most common electrolyte disorder among hospitalized patients and it is sometimes considered as a poor outcome predictor. Its correction is thus indicated, even in asymptomatic patients. The conventional treatment is represented by fluid restriction in presence of euvolemia or hypervolemia; whereas loop diuretics are used in some hypervolemic conditions (cardiac heart failure, liver cirrhosis and nephrotic syndrome) and intravenous isotonic or hypertonic solution are administered in hypovolemic conditions...
May 17, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28506373/heart-disease-and-the-liver-pathologic-evaluation
#16
REVIEW
Anne Knoll Koehne de Gonzalez, Jay H Lefkowitch
Liver injury due to acute and chronic heart failure has long been recognized. This article discusses the concepts of acute cardiogenic liver injury (ACLI) and cardiac or congestive hepatopathy (CH) along with their clinical manifestations and sequelae. Histologically, ACLI manifests as centrilobular hepatocellular necrosis, whereas CH is associated with centrilobular hepatocyte atrophy, dilated sinusoids, and perisinusoidal fibrosis, progressing to bridging fibrosis and ultimately cirrhosis. ACLI is associated with marked increases in aminotransferase levels, whereas CH is associated with a cholestatic pattern of laboratory tests...
June 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28488370/patients-with-cirrhosis-who-have-coronary-artery-disease-treated-with-cardiac-stents-have-high-rates-of-gastrointestinal-bleeding-but-no-increased-mortality
#17
T Krill, G Brown, R A Weideman, D J Cipher, S J Spechler, E Brilakis, L A Feagins
BACKGROUND: Patients with coronary artery disease (CAD) treated with stents require dual antiplatelet therapy (DAPT). For cirrhotics, who often have varices and coagulopathy, it is not clear if the risk of gastrointestinal bleeding (GIB) should preclude use of DAPT. AIM: To compare GIB and mortality rates in cirrhotics with CAD treated medically or with stents. METHODS: Using institutional databases, we identified patients with cirrhosis and CAD treated with stents or medical therapy between January 2000-September 2015...
May 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28485641/characterization-of-ascites-in-cardiac-cirrhosis-the-value-of-ascitic-fluid-protein-to-screen-for-concurrent-cardiac-cirrhosis
#18
Yuchen Wang, Bashar M Attar, Seema Gandhi, Palashkumar Jaiswal, Sara Bedsore, Neethi Paranji, Sachit Sharma
Abstracts Objectives: Cardiogenic ascites has been well described regarding its pathophysiology and fluid characteristics in prior literatures. However, ascites in patients with cardiac cirrhosis has not been characterized as a separate entity despite its unique pathophysiology and clinical aspects. This study aims to describe the fluid profile of ascites of cardiac cirrhosis and explore the utility of ascitic fluid protein (AFP) to predict concurrent cardiac cirrhosis. METHODS AND MATERIALS: We retrospectively selected and reviewed samples from the patients with cardiogenic ascites with and without concurrent cardiac cirrhosis...
May 9, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28484393/the-role-of-the-apelin-apj-system-in-the-regulation-of-liver-disease
#19
REVIEW
Xinrui Lv, Jing Kong, Wei-Dong Chen, Yan-Dong Wang
Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues. It has been shown that the apelin/APJ system plays various roles in physiology and pathophysiology of many organs. It regulates cardiovascular development or cardiac disease, glycometabolism and fat metabolism as well as metabolic disease. The apelin/APJ system participates in various cell activities such as proliferation, migration, apoptosis or inflammation...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28480728/hepatocellular-carcinoma-in-a-non-failing-fontan-circulation
#20
Efrén Martínez-Quintana, Alberto Monescillo, Fayna Rodríguez-González
Patients after a Fontan operation exhibit some degree of fibrosis which are primarily located in a sinusoidal or centrilobular pattern. Cirrhosis may develop years later and the incidence of cancer is up to 5%. That is why some authors recommend that patients who are >10 years out from their Fontan operation should undergo cardiac assessment as well as the determination of alpha-fetoprotein level, the realization of liver imaging tests or even liver biopsy to stay ahead of neoplastic transformation.
May 2017: Revista Española de Enfermedades Digestivas
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