keyword
https://read.qxmd.com/read/38473986/age-related-pathology-in-corticobasal-degeneration
#21
Maya Mimuro, Yasushi Iwasaki
Elderly human brains are vulnerable to multiple proteinopathies, although each protein has a different transmission pathway. Tau-immunoreactive astrocytes are well-known in elderly brains. In contrast, astrocytic plaques, a hallmark in corticobasal degeneration (CBD), rarely occur in aging and neurodegenerative disease other than CBD. To elucidate the clinicopathological correlation of aging-related pathology in CBD, we examined 21 pathologically proven CBD cases in our institute (12 males and 9 females, with a mean age of death 70...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473975/the-single-toxin-origin-of-alzheimer-s-disease-and-other-neurodegenerative-disorders-enables-targeted-approach-to-treatment-and-prevention
#22
REVIEW
Martin Tolar, John A Hey, Aidan Power, Susan Abushakra
New data suggest that the aggregation of misfolded native proteins initiates and drives the pathogenic cascade that leads to Alzheimer's disease (AD) and other age-related neurodegenerative disorders. We propose a unifying single toxin theory of brain neurodegeneration that identifies new targets and approaches to the development of disease-modifying treatments. An extensive body of genetic evidence suggests soluble aggregates of beta-amyloid (Aβ) as the primary neurotoxin in the pathogenesis of AD. New insights from fluid biomarkers, imaging, and clinical studies provide further evidence for the decisive impact of toxic Aβ species in the initiation and progression of AD...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472715/oxidative-stress-endoplasmic-reticulum-stress-and-apoptosis-in-the-pathology-of-alzheimer-s-disease
#23
REVIEW
Bidemi Emmanuel Ekundayo, Tajudeen Olabisi Obafemi, Olusola Bolaji Adewale, Blessing Ariyo Obafemi, Babatunji Emmanuel Oyinloye, Stella Kemilola Ekundayo
Alzheimer's disease (AD) accounts for a major statistic among the class of neurodegenerative diseases. A number of mechanisms have been identified in its pathogenesis and progression which include the amyloid beta (Aβ) aggregation, hyperphosphorylation of tau protein, oxidative stress, endoplasmic reticulum (ER) stress and apoptosis. These processes are interconnected and contribute significantly to the loss of neurons, brain mass and consequential memory loss and other cognitive difficulties. Oxidative stress in AD appears to be caused by excess of oxygen free radicals and extracellular Aβ deposits that cause local inflammatory processes and activate microglia, another possible source of reactive oxygen species (ROS)...
March 12, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38467392/extracellular-vesicles-in-alzheimer-s-disease
#24
JOURNAL ARTICLE
Victor Hugo Berriel Pinho, João Paulo Lima Daher, Salim Kanaan, Thalia Medeiros
Extracellular vesicles (EVs) are small vesicles released by cells that facilitate cell signaling. They are categorized based on their biogenesis and size. In the context of the central nervous system (CNS), EVs have been extensively studied for their role in both normal physiological functions and diseases like Alzheimer's disease (AD). AD is a neurodegenerative disorder characterized by cognitive decline and neuronal death. EVs have emerged as potential biomarkers for AD due to their involvement in disease progression...
March 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38457008/mitochondrial-disorders-leading-to-alzheimer-s-disease-perspectives-of-diagnosis-and-treatment
#25
REVIEW
Magdalena Pszczołowska, Kamil Walczak, Weronika Miśków, Magdalena Mroziak, Justyna Chojdak-Łukasiewicz, Jerzy Leszek
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause of dementia globally. The pathogenesis of AD remains still unclear. The three main features of AD are extracellular deposits of amyloid beta (Aβ) plaque, accumulation of abnormal formation hyper-phosphorylated tau protein, and neuronal loss. Mitochondrial impairment plays an important role in the pathogenesis of AD. There are problems with decreased activity of multiple complexes, disturbed mitochondrial fusion, and fission or formation of reactive oxygen species (ROS)...
March 8, 2024: GeroScience
https://read.qxmd.com/read/38454965/diagnosing-alzheimer-s-disease-which-dementia-screening-test-to-use-in-elderly-puerto-ricans-with-mild-cognitive-impairment-and-early-alzheimer-s-disease
#26
JOURNAL ARTICLE
María A Rodríguez-Santiago, Valerie Wojna, Eric Miranda-Valentín, Steven Arnold, Vanessa Sepúlveda-Rivera
Typically, Alzheimer's disease (AD) diagnosis is not made at its earliest period, for instance, at mild cognitive impairment (MCI) and early AD (E-AD). Our study aims to demonstrate a correlation between the screening tools, including the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Clinical Dementia Rating (CDR), and the biological biomarkers in the cerebrospinal fluid (CSF) amyloid beta 1-42 (Aβ42), phosphorylated tau (p-tau) proteins and total tau (t-tau)/Aβ42 ratio in Puerto Ricans > 55 years old with MCI and E-AD...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38454090/neuropathological-stage-dependent-proteome-mapping-of-the-olfactory-tract-in-alzheimer-s-disease-from-early-olfactory-related-omics-signatures-to-computational-repurposing-of-drug-candidates
#27
JOURNAL ARTICLE
Paz Cartas-Cejudo, Adriana Cortés, Mercedes Lachén-Montes, Elena Anaya-Cubero, Elena Puerta, Maite Solas, Joaquín Fernández-Irigoyen, Enrique Santamaría
Alzheimer's disease (AD) is the most common form of dementia, characterized by an early olfactory dysfunction, progressive memory loss, and behavioral deterioration. Albeit substantial progress has been made in characterizing AD-associated molecular and cellular events, there is an unmet clinical need for new therapies. In this study, olfactory tract proteotyping performed in controls and AD subjects (n = 17/group) showed a Braak stage-dependent proteostatic impairment accompanied by the progressive modulation of amyloid precursor protein and tau functional interactomes...
March 7, 2024: Brain Pathology
https://read.qxmd.com/read/38452694/penthorum-chinense-pursh-inhibits-ferroptosis-in-cellular-and-caenorhabditis-elegans-models-of-alzheimer-s-disease
#28
JOURNAL ARTICLE
Yuan-Yuan Yong, Lu Yan, Bin-Ding Wang, Dong-Sheng Fan, Min-Song Guo, Lu Yu, Jian-Ming Wu, Da-Lian Qin, Betty Yuen-Kwan Law, Vincent Kam-Wai Wong, Chong-Lin Yu, Xiao-Gang Zhou, An-Guo Wu
BACKGROUND: Ferroptosis, a unique type of cell death triggered by iron-dependent lipid peroxidation, plays a critical role in the pathogenesis of Alzheimer's disease (AD), a debilitating condition marked by memory loss and cognitive impairment due to the accumulation of beta-amyloid (Aβ) and hyperphosphorylated Tau protein. Increasing evidence suggests that inhibitors of ferroptosis could be groundbreaking in the treatment of AD. METHOD: In this study, we established in vitro ferroptosis using erastin-, RSL-3-, hemin-, and iFSP1-induced PC-12 cells...
February 16, 2024: Phytomedicine
https://read.qxmd.com/read/38441695/progranulin-and-neuropathological-features-of-alzheimer-s-disease-longitudinal-study
#29
JOURNAL ARTICLE
Fardin Nabizadeh, Rasa Zafari
BACKGROUND: Progranulin is an anti-inflammatory protein that plays an essential role in the synapse function and the maintenance of neurons in the central nervous system (CNS). It has been shown that the CSF level of progranulin increases in Alzheimer's disease (AD) patients and is associated with the deposition of amyloid-beta (Aβ) and tau in the brain tissue. In this study, we aimed to assess the longitudinal changes in cerebrospinal fluid (CSF) progranulin levels during different pathophysiological stages of AD and investigate associated AD pathologic features...
March 5, 2024: Aging Clinical and Experimental Research
https://read.qxmd.com/read/38427241/internalization-and-endosomal-trafficking-of-extracellular-tau-in-microglia-improved-by-%C3%AE-linolenic-acid
#30
JOURNAL ARTICLE
Smita Eknath Desale, Hariharakrishnan Chidambaram, Tazeen Qureshi, Subashchandrabose Chinnathambi
Alzheimer's disease (AD) is distinguished by extracellular accumulation of amyloid-beta plaques and intracellular neurofibrillary tangles of Tau. Pathogenic Tau species are also known to display "prion-like propagation," which explains their presence in extracellular spaces as well. Glial population, especially microglia, tend to proclaim neuroinflammatory condition, disrupted signaling mechanisms, and cytoskeleton deregulation in AD. Omega-3 fatty acids play a neuroprotective role in the brain, which can trigger the anti-inflammatory pathways as well as actin dynamics in the cells...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38427188/optimized-pre-analytical-handling-protocol-for-blood-based-biomarkers-of-alzheimer-s-disease
#31
JOURNAL ARTICLE
Alexander Jethwa, Laura Stöckl
The therapeutic management of patients with Alzheimer's disease (AD) has been hindered by poor diagnostic accuracy. As such, there is an unmet clinical need for tools that can detect and diagnose the disease in its early stages. Compared with cerebrospinal fluid (CSF)-based biomarkers or positron emission tomography (PET), the use of reliable blood-based biomarkers could offer an accessible and minimally invasive method of streamlining diagnosis in the clinical setting. However, the influence of pre-analytical processing and sample handling parameters on the accurate measurement of protein biomarkers is well established, especially for AD CSF-based biomarkers...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38424435/the-unveiling-of-therapeutic-targets-for-alzheimer-s-disease-an-integrative-review
#32
JOURNAL ARTICLE
Pratiksha Madar, Pooja Nagalapur, Somdatta Chaudhari, Devesh Sharma, Akshada Koparde, Rahul Buchade, Sandip Kshirsagar, Pravin Uttekar, Shailaja Jadhav, Praveen Chaudhari
Alzheimer's disease (AD) is characterized by a complex pathological landscape, necessitating a comprehensive treatment approach. This concise review paper delves into the idea of addressing multiple mechanisms in AD, summarizing the latest research findings on pathogenesis, risk factors, diagnostics, and therapeutic strategies. The etiology of AD is multifaceted, involving genetic, environmental, and lifestyle factors. The primary feature is the accumulation of amyloid-- beta and tau proteins, leading to neuroinflammation, synaptic dysfunction, oxidative stress, and neuronal loss...
February 28, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38423419/korean-red-ginseng-polysaccharide-as-a-potential-therapeutic-agent-targeting-tau-pathology-in-alzheimer-s-disease
#33
JOURNAL ARTICLE
Sujin Kim, Soo Jung Shin, Yunkwon Nam, Yong Ho Park, Byeong-Hyeon Kim, Hyun Ha Park, Vijay Kumar, Doo-Han Yoo, Yong Yook Lee, Hyang-Sook Hoe, Minho Moon
Tau is a microtubule-associated protein that plays a critical role in the stabilization and modulation of neuronal axons. Tau pathology is stronger associated with cognitive decline in patients with Alzheimer's disease (AD) than amyloid beta (Aβ) pathology. Hence, tau targeting is a promising approach for the treatment of AD. Previous studies have demonstrated that the non-saponin fraction with rich polysaccharide (NFP) from Korean red ginseng (KRG) can modulate tau aggregation and exert a therapeutic effect on AD...
February 27, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38411868/traumatic-brain-injury-in-mice-generates-early-stage-alzheimer-s-disease-related-protein-pathology-that-correlates-with-neurobehavioral-deficits
#34
JOURNAL ARTICLE
Nicholas Panayi, Philip Schulz, Ping He, Brandon Hanna, Jonathan Lifshitz, Rachel K Rowe, Michael R Sierks
Traumatic brain injury (TBI) increases the long-term risk of neurodegenerative diseases, including Alzheimer's disease (AD). Here, we demonstrate that protein variant pathology generated in brain tissue of an experimental TBI mouse model is similar to protein variant pathology observed during early stages of AD, and that subacute accumulation of AD associated variants of amyloid beta (Aβ) and tau in the TBI mouse model correlated with behavioral deficits. Male C57BL/6 mice were subjected to midline fluid percussion injury or to sham injury, after which sensorimotor function (rotarod, neurological severity score), cognitive deficit (novel object recognition), and affective deficits (elevated plus maze, forced swim task) were assessed post-injury (DPI)...
February 27, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38406609/association-of-csf-biomarkers-with-mri-brain-changes-in-alzheimer-s-disease
#35
JOURNAL ARTICLE
Nazib M Seidu, Silke Kern, Simona Sacuiu, Therese Rydberg Sterner, Kaj Blennow, Henrik Zetterberg, Olof Lindberg, Daniel Ferreira, Eric Westman, Anna Zettergren, Ingmar Skoog
The relation between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures is poorly understood in cognitively healthy individuals from the general population. Participants' ( n  = 226) mean age was 70.9 years (SD = 0.4). CSF concentrations of amyloid beta (Aβ)1-42, total tau (t-tau), phosphorylated tau (p-tau), neurogranin, and neurofilament light, and volumes of hippocampus, amygdala, total basal forebrain (TBF), and cortical thickness were measured...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38398861/potential-therapeutic-effects-of-bifidobacterium-breve-mcc1274-on-alzheimer-s-disease-pathologies-in-app-nl-g-f-mice
#36
JOURNAL ARTICLE
Mona Abdelhamid, Cha-Gyun Jung, Chunyu Zhou, Rieko Inoue, Yuxin Chen, Yoshiki Sento, Hideki Hida, Makoto Michikawa
We previously demonstrated that orally supplemented Bifidobacterium breve MCC1274 ( B. breve MCC1274) mitigated Alzheimer's disease (AD) pathologies in both 7-month-old AppNL-G-F mice and wild-type mice; thus, B. breve MCC1274 supplementation might potentially prevent the progression of AD. However, the possibility of using this probiotic as a treatment for AD remains unclear. Thus, we investigated the potential therapeutic effects of this probiotic on AD using 17-month-old AppNL-G-F mice with memory deficits and amyloid beta saturation in the brain...
February 15, 2024: Nutrients
https://read.qxmd.com/read/38397410/the-complex-interplay-between-toxic-hallmark-proteins-calmodulin-binding-proteins-ion-channels-and-receptors-involved-in-calcium-dyshomeostasis-in-neurodegeneration
#37
REVIEW
Danton H O'Day
Calcium dyshomeostasis is an early critical event in neurodegeneration as exemplified by Alzheimer's (AD), Huntington's (HD) and Parkinson's (PD) diseases. Neuronal calcium homeostasis is maintained by a diversity of ion channels, buffers, calcium-binding protein effectors, and intracellular storage in the endoplasmic reticulum, mitochondria, and lysosomes. The function of these components and compartments is impacted by the toxic hallmark proteins of AD (amyloid beta and Tau), HD (huntingtin) and PD (alpha-synuclein) as well as by interactions with downstream calcium-binding proteins, especially calmodulin...
January 31, 2024: Biomolecules
https://read.qxmd.com/read/38393914/alpha-beta-and-gamma-secretase-amyloid-precursor-protein-and-tau-protein-genes-in-the-hippocampal-ca3-subfield-in-an-ischemic-model-of-alzheimer-s-disease-with-survival-up-to-2-years
#38
JOURNAL ARTICLE
Stanisł Aw J Czuczwar, Janusz Kocki, Barbara Miziak, Jacek Bogucki, Anna Bogucka-Kocka, Ryszard Pluta
BACKGROUND: Understanding the phenomena underlying the non-selective susceptibility to ischemia of pyramidal neurons in the CA3 is important from the point of view of elucidating the mechanisms of memory loss and the development of dementia. OBJECTIVE: The aim of the study was to investigate changes in genes expression of amyloid precursor protein, its cleaving enzymes and tau protein in CA3 post-ischemia with survival of 12-24 months. METHODS: We used an ischemic model of Alzheimer's disease to study the above genes using an RT-PCR protocol...
February 19, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38393535/molecular-cross-talk-between-long-covid-19-and-alzheimer-s-disease
#39
REVIEW
Magdalena Pszczołowska, Kamil Walczak, Weronika Misków, Katarzyna Antosz, Joanna Batko, Julia Karska, Jerzy Leszek
The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the widespread problems. Some of its symptoms affect the nervous system and resemble symptoms of Alzheimer's disease (AD)-a neurodegenerative condition caused by the accumulation of amyloid beta and hyperphosphorylation of tau proteins. Multiple studies have found dependence between these two conditions. Patients with Alzheimer's disease have a greater risk of SARS-CoV-2 infection due to increased levels of angiotensin-converting enzyme 2 (ACE2), and the infection itself promotes amyloid beta generation which enhances the risk of AD...
February 23, 2024: GeroScience
https://read.qxmd.com/read/38378122/transcriptomic-evaluation-of-tau-and-tdp-43-synergism-shows-tauopathy-predominance-and-reveals-potential-modulating-targets
#40
JOURNAL ARTICLE
Vaishnavi S Jadhav, Jade G Stair, Randall J Eck, Samuel N Smukowski, Heather N Currey, Laura Garcia Toscano, Joshua C Hincks, Caitlin S Latimer, Paul N Valdmanis, Brian C Kraemer, Nicole F Liachko
Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the protein TDP-43 as a secondary pathology. The presence of TDP-43 pathology in AD is associated with increased tau neuropathology and worsened clinical outcomes in AD patients. Using C. elegans models of mixed pathology in AD, we have previously shown that TDP-43 specifically synergizes with tau but not Aβ, resulting in enhanced neuronal dysfunction, selective neurodegeneration, and increased accumulation of pathological tau...
February 18, 2024: Neurobiology of Disease
keyword
keyword
20213
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.