keyword
MENU ▼
Read by QxMD icon Read
search

Oxygen mediated ion channels

keyword
https://www.readbyqxmd.com/read/29614632/sickle-cell-dehydration-pathophysiology-and-therapeutic-applications
#1
Carlo Brugnara
Cell dehydration is a distinguishing characteristic of sickle cell disease and an important contributor to disease pathophysiology. Due to the unique dependence of Hb S polymerization on cellular Hb S concentration, cell dehydration promotes polymerization and sickling. In double heterozygosis for Hb S and C (SC disease) dehydration is the determining factor in disease pathophysiology. Three major ion transport pathways are involved in sickle cell dehydration: the K-Cl cotransport (KCC), the Gardos channel (KCNN4) and Psickle, the polymerization induced membrane permeability, most likely mediated by the mechano-sensitive ion channel PIEZO1...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29550927/cooperative-electrogenic-proton-transport-pathways-in-the-plasma-membrane-of-the-proton-secreting-osteoclast
#2
REVIEW
Miyuki Kuno
A proton is a ubiquitous signaling ion. Many transmembrane H+ transport pathways either maintain pH homeostasis or generate acidic compartments. The osteoclast is a bone-resorbing cell, which degrades bone tissues by secreting protons and lysosomal enzymes into the resorption pit. The plasma membrane facing bone tissue (ruffled border), generated partly by fusion of lysosomes, may mimic H+ flux mechanisms regulating acidic vesicles. We identified three electrogenic H+ -fluxes in osteoclast plasma membranes-a vacuolar H+ -ATPase (V-ATPase), a voltage-gated proton channel (Hv channel) and an acid-inducible H+ -leak-whose electrophysiological profiles and regulation mechanisms differed...
March 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29491840/neuropathic-pain-delving-into-the-oxidative-origin-and-the-possible-implication-of-transient-receptor-potential-channels
#3
REVIEW
Cristina Carrasco, Mustafa Naziroǧlu, Ana B Rodríguez, José A Pariente
Currently, neuropathic pain is an underestimated socioeconomic health problem affecting millions of people worldwide, which incidence may increase in the next years due to chronification of several diseases, such as cancer and diabetes. Growing evidence links neuropathic pain present in several disorders [i.e., spinal cord injury (SCI), cancer, diabetes and alcoholism] to central sensitization, as a global result of mitochondrial dysfunction induced by oxidative and nitrosative stress. Additionally, inflammatory signals and the overload in intracellular calcium ion could be also implicated in this complex network that has not yet been elucidated...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467654/the-p2x7-receptor-in-inflammatory-diseases-angel-or-demon
#4
REVIEW
Luiz E B Savio, Paola de Andrade Mello, Cleide Gonçalves da Silva, Robson Coutinho-Silva
Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the extracellular milieu, being massively released by stressed or dying cells. Once outside the cells, ATP and related nucleotides/nucleoside generated by ectonucleotidases mediate a high evolutionary conserved signaling system: the purinergic signaling, which is involved in a variety of pathological conditions, including inflammatory diseases. Extracellular ATP has been considered an endogenous adjuvant that can initiate inflammation by acting as a danger signal through the activation of purinergic type 2 receptors-P2 receptors (P2Y G-protein coupled receptors and P2X ligand-gated ion channels)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29327205/nociceptive-roles-of-trpm2-ion-channel-in-pathologic-pain
#5
REVIEW
Yongwoo Jang, Pyung Sun Cho, Young Duk Yang, Sun Wook Hwang
Pain is a protective mechanism that enables us to avoid potentially harmful environments. However, when pathologically persisted and aggravated under severely injured or inflamed conditions, pain often reduces the quality of life and thus is considered as a disease to eliminate. Inflammatory and/or neuropathic mechanisms may exaggerate interactions between damaged tissues and neural pathways for pain mediation. Similar mechanisms also promote the communication among cellular participants in synapses at spinal or higher levels, which may amplify nociceptive firing and subsequent signal transmission, deteriorating the pain sensation...
January 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29248456/endothelin-2-injures-the-blood-retinal-barrier-and-macroglial-m%C3%A3-ller-cells-interactions-with-angiotensin-ii-aldosterone-and-nadph-oxidase
#6
Saeed F Alrashdi, Devy Deliyanti, Dean M Talia, Jennifer L Wilkinson-Berka
Although increasing evidence indicates that endothelin-2 (Edn2) has distinct roles in tissue pathology, including inflammation, glial cell dysfunction, and angiogenesis, its role in the retina and the factors that regulate its actions are not fully understood. We hypothesized that Edn2 damages the blood-retinal barrier (BRB) and that this is mediated by interactions with the renin-angiotensin-aldosterone system and reactive oxygen species derived from NADPH oxidase (Nox). C57BL/6J mice received an intravitreal injection of Edn2 or control vehicle to examine the blood pressure-independent effects of Edn2...
March 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29237825/mitochondrial-ca-2-transport-in-the-endothelium-regulation-by-ions-redox-signalling-and-mechanical-forces
#7
REVIEW
B Rita Alevriadou, Santhanam Shanmughapriya, Akshar Patel, Peter B Stathopulos, Muniswamy Madesh
Calcium (Ca2+ ) transport by mitochondria is an important component of the cell Ca2+ homeostasis machinery in metazoans. Ca2+ uptake by mitochondria is a major determinant of bioenergetics and cell fate. Mitochondrial Ca2+ uptake occurs via the mitochondrial Ca2+ uniporter (MCU) complex, an inner mitochondrial membrane protein assembly consisting of the MCU Ca2+ channel, as its core component, and the MCU complex regulatory/auxiliary proteins. In this review, we summarize the current knowledge on the molecular nature of the MCU complex and its regulation by intra- and extramitochondrial levels of divalent ions and reactive oxygen species (ROS)...
December 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29184198/activation-of-planarian-trpa1-by-reactive-oxygen-species-reveals-a-conserved-mechanism-for-animal-nociception
#8
Oscar M Arenas, Emanuela E Zaharieva, Alessia Para, Constanza Vásquez-Doorman, Christian P Petersen, Marco Gallio
All animals must detect noxious stimuli to initiate protective behavior, but the evolutionary origin of nociceptive systems is not well understood. Here we show that noxious heat and irritant chemicals elicit robust escape behaviors in the planarian Schmidtea mediterranea and that the conserved ion channel TRPA1 is required for these responses. TRPA1-mutant Drosophila flies are also defective in noxious-heat responses. We find that either planarian or human TRPA1 can restore noxious-heat avoidance to TRPA1-mutant Drosophila, although neither is directly activated by heat...
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29182327/nonredox-metal-ions-promoted-olefin-epoxidation-by-iron-ii-complexes-with-h-2-o-2-dft-calculations-reveal-multiple-channels-for-oxygen-transfer
#9
Jisheng Zhang, Wen-Jie Wei, Xiaoyan Lu, Hang Yang, Zhuqi Chen, Rong-Zhen Liao, Guochuan Yin
Nonredox metal ions play significant roles in a wide range of biological and chemical oxidations in which they can modulate the oxidative reactivity of those redox metal ions. With environmentally benign H2 O2 as oxidant, the influence of nonredox metal ions on an iron(II) complex mediated olefin epoxidation was investigated through experimental studies and theoretical calculations. It was found that adding nonredox metal ions like Sc3+ can substantially improve the oxygen transfer efficiency of the iron(II) complex toward cyclooctene epoxidation even in the presence of certain amount of water...
December 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29137386/mitochondrial-calcium-uniporter-as-a-target-of-microrna-340-and-promoter-of-metastasis-via-enhancing-the-warburg-effect
#10
Changhui Yu, Yuhao Wang, Jiawen Peng, Qiang Shen, Mimi Chen, Wei Tang, Xiumei Li, Chunqing Cai, Bin Wang, Shaoxi Cai, Xiaojing Meng, Fei Zou
Background: A shift from oxygen phosphorylation to aerobic glycolysis was known as the Warburg effect and a characteristic of cancer cell metabolism facilitating metastasis. Mitochondrial calcium uniporter (MCU), a key ion channel that mediates Ca2+ uptake into mitochondria, was found to promote cancer progression and metastasis. However, its explicit role in shifting metabolism of breast cancer cells has not been defined. Methods: We evaluated MCU overexpression or knock-down on migration, invasion and glucose metabolismin breast cancer cells...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29111328/3-naphthalen-2-yl-propoxy-methyl-azetidine-hydrochloride-attenuates-nlrp3-inflammasome-mediated-signaling-pathway-in-lipopolysaccharide-stimulated-bv2-microglial-cells
#11
Ji Woong Yang, Seung-Ju Yang, Jung-Min Na, Hoh-Gyu Hahn, Sung-Woo Cho
The nucleotide-binding and oligomerization domain-like receptor containing a pyrin domain 3 (NLRP3) inflammasome is a multiprotein complex with a role in innate immune responses. NLRP3 inflammasome dysfunction is a common feature of chronic inflammatory diseases. Microglia activation is also associated with neuroinflammatory pathologies. We previously reported that 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride (KHG26792) reduced hypoxia-induced toxicity by modulating inflammation. However, no studies have elucidated the precise mechanisms for the anti-inflammatory action of KHG26792, in particular via inflammasome mediation...
October 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29047078/role-of-transcription-factors-in-pulmonary-artery-smooth-muscle-cells-an-important-link-to-hypoxic-pulmonary-hypertension
#12
Annarita Di Mise, Yong-Xiao Wang, Yun-Min Zheng
Hypoxia, namely a lack of oxygen in the blood, induces pulmonary vasoconstriction and vasoremodeling, which serve as essential pathologic factors leading to pulmonary hypertension (PH). The underlying molecular mechanisms are uncertain; however, pulmonary artery smooth muscle cells (PASMCs) play an essential role in hypoxia-induced pulmonary vasoconstriction, vasoremodeling, and PH. Hypoxia causes oxidative damage to DNAs, proteins, and lipids. This damage (oxidative stress) modulates the activity of ion channels and elevates the intracellular calcium concentration ([Ca(2+)]i, Ca(2+) signaling) of PASMCs...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28970012/tanshinone-iia-sodium-sulfonate-regulates-antioxidant-system-inflammation-and-endothelial-dysfunction-in-atherosclerosis-by-downregulation-of-clic1
#13
Ji Zhu, Yingling Xu, Guangyan Ren, Xiao Hu, Cui Wang, Zhen Yang, Zhuoyu Li, Wei Mao, Dezhao Lu
BACKGROUND: Tanshinone IIA Sodium sulfonate (STS) is clinically used for treating cardiovascular diseases in Traditional Chinese Medicine due to its antioxidation and anti-inflammation activities. Intracellular chloride channel 1 (CLIC1) participates in the regulation of oxidative stress and inflammation. This study investigates whether CLIC1 mediates the cardioprotective effects of STS. METHODS: STS were used to treat atherosclerosis (AS) induced by feeding Apolipoprotein E-deficient (ApoE(-/-)) mice with a high-fat, cholesterol-rich diet...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28877447/limiting-oxidative-stress-following-neurotrauma-with-a-combination-of-ion-channel-inhibitors
#14
Hannah R Milbourn, Lillian M Toomey, Nikolas Gavriel, Chloe G G Gray, Alexander H Gough, Marcus K Giacci, Melinda Fitzgerald
Following injury to the central nervous system, secondary degeneration is mediated by Ca2+ imbalances and overproduction of reactive oxygen species from mitochondria, and is associated with myelin deficits and loss of function. Preventing intracellular Ca2+ influx at the acute phase of injury is a potential strategy for limiting these deficits and preserving function. The use of single ion channel inhibitors has had little success in attenuating morphological and functional deficits, potentially due to the many pathways by which calcium can traverse the cell membrane...
June 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28875346/cftr-supports-cell-death-through-ros-dependent-activation-of-tmem16f-anoctamin-6
#15
Filipa Simões, Jiraporn Ousingsawat, Podchanart Wanitchakool, Ana Fonseca, Inês Cabrita, Roberta Benedetto, Rainer Schreiber, Karl Kunzelmann
Cystic fibrosis transmembrane conductance regulator (CFTR) is the essential chloride and bicarbonate channel in the apical membrane of epithelial cells. CFTR was also proposed earlier to conduct glutathione (GSH) out of airway epithelial cells to be enriched in the apical airway surface liquid to neutralize reactive oxygen species (ROS). Although earlier studies suggested that release of GSH by wild type (wt) CFTR may lead to an increase in cytosolic ROS, we did not detect different ROS levels in cells expressing wt-CFTR and mutant F508del-CFTR, independent of CFTR-activation or exposure to the ROS donor tert-butyl hydroperoxide...
February 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28855912/salt-sensitive-signaling-networks-in-the-mediation-of-k-na-homeostasis-gene-expression-in-glycyrrhiza-uralensis-roots
#16
Tao Lang, Shurong Deng, Nan Zhao, Chen Deng, Yinan Zhang, Yanli Zhang, Huilong Zhang, Gang Sa, Jun Yao, Caiwu Wu, Yanhong Wu, Qun Deng, Shanzhi Lin, Jianxin Xia, Shaoliang Chen
We investigated the effects of salt-sensitive signaling molecules on ionic fluxes and gene expression related to K(+)/Na(+) homeostasis in a perennial herb, Glycyrrhiza uralensis, during short-term NaCl stress (100 mM, 24 h). Salt treatment caused more pronounced Na(+) accumulation in root cells than in leaf cells. Na(+) ions were mostly compartmentalized in vacuoles. Roots exposed to NaCl showed increased levels of extracellular ATP (eATP), cytosolic Ca(2+), H2O2, and NO. Steady-state flux recordings revealed that these salt-sensitive signaling molecules enhanced NaCl-responsive Na(+) efflux, due to the activated Na(+)/H(+) antiport system in the plasma membrane (PM)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28748217/mechanisms-and-applications-of-the-anti-inflammatory-effects-of-photobiomodulation
#17
Michael R Hamblin
Photobiomodulation (PBM) also known as low-level level laser therapy is the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation. The primary chromophores have been identified as cytochrome c oxidase in mitochondria, and calcium ion channels (possibly mediated by light absorption by opsins). Secondary effects of photon absorption include increases in ATP, a brief burst of reactive oxygen species, an increase in nitric oxide, and modulation of calcium levels. Tertiary effects include activation of a wide range of transcription factors leading to improved cell survival, increased proliferation and migration, and new protein synthesis...
2017: AIMS Biophysics
https://www.readbyqxmd.com/read/28718507/gene-expression-analyses-reveal-metabolic-specifications-in-acute-o2-sensing-chemoreceptor-cells
#18
Lin Gao, Victoria Bonilla-Henao, Paula García-Flores, Ignacio Arias-Mayenco, Patricia Ortega-Sáenz, José López-Barneo
KEY POINTS: Glomus cells in the carotid body (CB) and chromaffin cells in the adrenal medulla (AM) are essential for reflex cardiorespiratory adaptation to hypoxia. However, the mechanisms whereby these cells detect changes in O2 tension are poorly understood. The metabolic properties of acute O2 -sensing cells have been investigated by comparing the transcriptomes of CB and AM cells, which are O2 -sensitive, with superior cervical ganglion neurons, which are practically O2 -insensitive...
September 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28696294/trpm7-senses-oxidative-stress-to-release-zn-2-from-unique-intracellular-vesicles
#19
Sunday A Abiria, Grigory Krapivinsky, Rajan Sah, Ana G Santa-Cruz, Dipayan Chaudhuri, Jin Zhang, Pichet Adstamongkonkul, Paul G DeCaen, David E Clapham
TRPM7 (transient receptor potential cation channel subfamily M member 7) regulates gene expression and stress-induced cytotoxicity and is required in early embryogenesis through organ development. Here, we show that the majority of TRPM7 is localized in abundant intracellular vesicles. These vesicles (M7Vs) are distinct from endosomes, lysosomes, and other familiar vesicles or organelles. M7Vs accumulate Zn2+ in a glutathione-enriched, reduced lumen when cytosolic Zn2+ concentrations are elevated. Treatments that increase reactive oxygen species (ROS) trigger TRPM7-dependent Zn2+ release from the vesicles, whereas reduced glutathione prevents TRPM7-dependent cytosolic Zn2+ influx...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28679281/lipid-mediated-modulation-of-intracellular-ion-channels-and-redox-state-physiopathological-implications
#20
Marisa Brini, Luigi Leanza, Ildiko Szabo
SIGNIFICANCE: Ion channels play an important role in the regulation of organelle function within the cell, as proven by increasing evidence pointing to a link between altered function of intracellular ion channels and different pathologies ranging from cancer to neurodegenerative diseases, ischemic damage, and lysosomal storage diseases. Recent Advances: A link between these pathologies and redox state as well as lipid homeostasis and ion channel function is in the focus of current research...
September 21, 2017: Antioxidants & Redox Signaling
keyword
keyword
20212
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"