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Juvenile RA treatment

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https://www.readbyqxmd.com/read/27843575/effectiveness-and-safety-of-tnf-inhibitors-in-adults-with-juvenile-idiopathic-arthritis
#1
Lianne Kearsley-Fleet, Flora McErlane, Helen E Foster, Mark Lunt, Kath D Watson, Deborah P M Symmons, Kimme L Hyrich
INTRODUCTION: Many children with juvenile idiopathic arthritis (JIA) continue to have active disease into adulthood. Adults with JIA are a heterogeneous group, and the effects of tumour necrosis factor inhibitor (TNFi) therapies are not well described. This analysis aims to describe treatment outcomes among patients with JIA starting TNFi for the first time in adulthood. METHODS: Patients with arthritis onset <16 years starting their first TNFi therapy were identified from the British Society of Rheumatology Biologics Register...
2016: RMD Open
https://www.readbyqxmd.com/read/27779782/use-of-tumor-necrosis-factor-alpha-inhibitors-in-children-and-young-adults-with-juvenile-idiopathic-arthritis-or-rheumatoid-arthritis
#2
Wan-Ju Lee, Leslie Briars, Todd A Lee, Gregory S Calip, Katie J Suda, Glen T Schumock
OBJECTIVE: To characterize the use of tumor necrosis factor-alpha inhibitors (TNFI) in children with juvenile idiopathic arthritis (JIA) and young adults with rheumatoid arthritis (RA). METHODS: Patients with incident JIA or RA were identified using the Truven Health MarketScan Commercial Claims and Encounters database from 2009 to 2013. The incident diagnosis was defined as no prior claims with a JIA/RA code and no JIA/RA medications recorded during the previous 6 months...
October 25, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27752356/juvenile-idiopathic-arthritis-in-adulthood-fulfilment-of-classification-criteria-for-adult-rheumatic-diseases-long-term-outcomes-and-predictors-of-inactive-disease-functional-status-and-damage
#3
Filipa Oliveira-Ramos, Mónica Eusébio, Fernando M Martins, Ana Filipa Mourão, Carolina Furtado, Raquel Campanilho-Marques, Inês Cordeiro, Joana Ferreira, Marcos Cerqueira, Ricardo Figueira, Iva Brito, Helena Canhão, Maria José Santos, José A Melo-Gomes, João Eurico Fonseca
OBJECTIVES: To determine how adult juvenile idiopathic arthritis (JIA) patients fulfil classification criteria for adult rheumatic diseases, evaluate their outcomes and determine clinical predictors of inactive disease, functional status and damage. METHODS: Patients with JIA registered on the Rheumatic Diseases Portuguese Register (Reuma.pt) older than 18 years and with more than 5 years of disease duration were included. Data regarding sociodemographic features, fulfilment of adult classification criteria, Health Assessment Questionnaire, Juvenile Arthritis Damage Index-articular (JADI-A) and Juvenile Arthritis Damage Index-extra-articular (JADI-E) damage index and disease activity were analysed...
2016: RMD Open
https://www.readbyqxmd.com/read/27539792/overexpression-of-the-transmembrane-carbonic-anhydrase-isoforms-ix-and-xii-in-the-inflamed-synovium
#4
Francesca Margheri, Mariangela Ceruso, Fabrizio Carta, Anna Laurenzana, Laura Maggi, Simone Lazzeri, Gabriele Simonini, Francesco Annunziato, Mario Del Rosso, Claudiu T Supuran, Rolando Cimaz
Juvenile idiopathic arthritis (JIA) is the most common form of chronic rheumatic disease affecting children worldwide, with some features similar to adult rheumatoid arthritis (RA). In the present study, we aim at investigating novel markers that will allow in the future for tailored, more personalized treatment strategies. Hence, taking notice of several reports proving the role of local acidosis as a causal link between inflammatory diseases and related pain, and the involvement of several carbonic anhydrases (CA, EC 4...
August 15, 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/27086969/inhibition-of-trkb-limits-development-of-the-zebra-finch-song-system
#5
Linda Qi Beach, Yu Ping Tang, Halie Kerver, Juli Wade
Large sexual dimorphisms exist in the zebra finch song system. Masculinization may be mediated by both estradiol and expression of one or more Z-genes (males: ZZ; females: ZW). Roles of the Z-gene tyrosine kinase B (TrkB) in HVC in masculinizing both HVC and one of its targets the robust nucleus of the arcopallium (RA), were tested using siRNA administration in juvenile males at two ages (post-hatching days 15-17 or 25-27). Birds were euthanized 10 days later. Potential interactions or additive effects with estradiol were evaluated by treating males with the estrogen synthesis inhibitor fadrozole...
July 1, 2016: Brain Research
https://www.readbyqxmd.com/read/26773106/development-of-system-level-performance-measures-for-evaluation-of-models-of-care-for-inflammatory-arthritis-in-canada
#6
Claire E H Barber, Deborah A Marshall, Dianne P Mosher, Pooneh Akhavan, Lori Tucker, Kristin Houghton, Michelle Batthish, Deborah M Levy, Heinrike Schmeling, Janet Ellsworth, Heidi Tibollo, Sean Grant, Dmitry Khodyakov, Diane Lacaille
OBJECTIVE: To develop system-level performance measures for evaluating the care of patients with inflammatory arthritis (IA), including rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis. METHODS: This study involved several methodological phases. Over multiple rounds, various participants were asked to help define a set of candidate measurement themes. A systematic search was conducted of existing guidelines and measures...
March 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/26663412/comparative-risk-of-harm-associated-with-the-use-of-targeted-immunomodulators-a-systematic-review
#7
Rishi J Desai, Kylie J Thaler, Peter Mahlknecht, Gerald Gartlehner, Marian S McDonagh, Bita Mesgarpour, Alireza Mazinanian, Anna Glechner, Chandrasekar Gopalakrishnan, Richard A Hansen
OBJECTIVE: To systematically compare the risk of adverse events (AEs) for 13 targeted immunomodulators (TIMs) indicated for ankylosing spondylitis (AS), inflammatory bowel diseases, juvenile idiopathic arthritis, plaque psoriasis, psoriatic arthritis (PsA), or rheumatoid arthritis (RA). METHODS: We searched electronic databases through July 2015 to retrieve randomized controlled trials (RCTs) and observational studies comparing AEs between 2 or more TIMs head-to-head...
August 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26632609/aldh-enzyme-expression-is-independent-of-the-spermatogenic-cycle-and-their-inhibition-causes-misregulation-of-murine-spermatogenic-processes
#8
Travis Kent, Samuel L Arnold, Rachael Fasnacht, Ross Rowsey, Debra Mitchell, Cathryn A Hogarth, Nina Isoherranen, Michael D Griswold
Perturbations in the vitamin A metabolism pathway could be a significant cause of male infertility, as well as a target toward the development of a male contraceptive, necessitating the need for a better understanding of how testicular retinoic acid (RA) concentrations are regulated. Quantitative analyses have recently demonstrated that RA is present in a pulsatile manner along testis tubules. However, it is unclear if the aldehyde dehydrogenase (ALDH) enzymes, which are responsible for RA synthesis, contribute to the regulation of these RA concentration gradients...
January 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/26629984/subcutaneous-tocilizumab-for-the-treatment-of-rheumatoid-arthritis
#9
Emma Mitchell, Graeme Jones
Rheumatoid arthritis (RA) is characterized by inflammatory synovitis and is mediated by several cytokines; this includes interleukin-6, whose receptor has been successfully targeted by the humanized monoclonal antibody tocilizumab. Intravenous tocilizumab (TCZ-IV) is registered for use in RA (alone or as combination therapy), systemic juvenile idiopathic arthritis and Castleman disease. Subcutaneous tocilizumab (TCZ-SC) is a desirable alternative to existing subcutaneous biological disease modifying antirheumatic drugs (bDMARDs) targeting tumor necrosis factor...
2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/26390101/a-report-of-three-cases-with-acquired-generalized-lipodystrophy-with-distinct-autoimmune-conditions-treated-with-metreleptin
#10
Jasmin Lebastchi, Nevin Ajluni, Adam Neidert, Elif A Oral
CONTEXT: Acquired generalized lipodystrophy (AGL) is associated with leptin deficiency as a result of adipose tissue loss and hypertriglyceridemia, insulin resistance, and hepatic steatosis. It may coexist with other autoimmune diseases such as Hashimoto's thyroiditis, rheumatoid arthritis, hemolytic anemia, and chronic active hepatitis. Metreleptin therapy has been shown to improve metabolic abnormalities in lipodystrophy, but the effect on AGL patients with active autoimmune disease is unknown...
November 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26255077/-reduced-activation-and-cd3-lymphocyte-recruitment-after-tnf-inhibitor-use-evaluation-of-clinical-and-99mtc-okt3-scintigraphic-response-in-a-patient-with-juvenile-idiopathic-arthritis
#11
Flavia Paiva Proença Lobo Lopes, Sergio Augusto Lopes de Souza, Blanca Elena Rios Gomes Bica, Lea Mirian Barbosa da Fonseca, Mario Newton Leitão de Azevedo, Bianca Gutfilen
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease observed in children up to 16 years. It is known that JIA occurs due to a chronic joint inflammation that involves a cascade of responses amongst which the involvement of CD3 complex can be cited. CD3 molecular complex must be present on T lymphocyte so that the receptor can be expressed by the cell and activate it. In the juvenile form of rheumatoid arthritis, CD3 complex activates cells and TNF-alpha production. Thus, an examination using an antibody that binds to this complex would enable a diagnosis with high sensitivity and specificity values...
July 26, 2015: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/26150616/a-case-of-neurosarcoidosis-secondary-to-treatment-of-etanercept-and-review-of-the-literature
#12
REVIEW
Idanis Berrios, Adalia Jun-O'Connell, Sorina Ghiran, Carolina Ionete
There are only three cases in the literature that describe development of neurosarcoidosis in a patient who is on tumour necrosis factor α inhibitors. We describe a case of a 33-year-old woman with a history of juvenile rheumatoid arthritis and refractory uveitis (with previous treatment trials of adalimumab, infliximab, mycophenolate, methotrexate) who had been stable for 2 years on etanercept. She was diagnosed with biopsy-proven systemic sarcoidosis with meningeal and parenchymal neurosarcoidosis. She was switched to infliximab and methotrexate, with clinical and imaging improvements...
July 6, 2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26141633/potential-roles-of-gonadotropins-to-control-pulsatile-retinoic-acid-signaling-during-spermatogenesis
#13
Seyedmehdi Nourashrafeddin
Spermatogenesis is a highly regulated process that takes place in the seminiferous tubules of testis. This process initiates at puberty with differentiation of spermatogonia and their meiotic entry. The initiation of spermatogenesis depends on gonadotropins secreted by the pituitary gland; i.e., follicle-stimulating hormone (FSH) and luteinizing hormone (LH). In the absence of FSH and LH only premeiotic germ cells are present in the testis. The prepubertal development phase in juvenile testis is characterized by a protracted hypogonadotropic state, which only consists of Sertoli and undifferentiated germ cells in the seminiferous epithelium...
September 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/26136859/role-of-basophils-in-rheumatoid-arthritis-review
#14
Pei Tang, Qiuhua Chen, Qiaofen Lan, Yanwen Chen, Haijuan Yang, Ning An, Haiyan Xiao, Huafeng Liu, Ping Wu, Tong Xie, Qingjun Pan
The T helper (Th)1/Th2 imbalance plays a crucial role in the development of rheumatoid arthritis (RA). It is well known that basophils can affect the Th1/Th2 balance by enhancing the Th2 response, while impairing the Th1 response, which is known to be involved in the development of a number of diseases. However, limited information is available with regard to the role of basophils in RA. Decreased levels of circulating basophils and a dominant Th1 response have been reported in adult patients with RA, while children with juvenile RA have been largely found to have increased levels of circulating basophils and a dominant Th2 response...
May 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26126608/use-of-rna-sequencing-to-evaluate-rheumatic-disease-patients
#15
REVIEW
Eugenia G Giannopoulou, Olivier Elemento, Lionel B Ivashkiv
Studying the factors that control gene expression is of substantial importance for rheumatic diseases with poorly understood etiopathogenesis. In the past, gene expression microarrays have been used to measure transcript abundance on a genome-wide scale in a particular cell, tissue or organ. Microarray analysis has led to gene signatures that differentiate rheumatic diseases, and stages of a disease, as well as response to treatments. Nowadays, however, with the advent of next-generation sequencing methods, massive parallel sequencing of RNA tends to be the technology of choice for gene expression profiling, due to several advantages over microarrays, as well as for the detection of non-coding transcripts and alternative splicing events...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26083391/quality-of-life-and-drug-compliance-their-interrelationship-in-rheumatic-patients
#16
Lucie Hromadkova, Tomas Soukup, Jiri Vlcek
RATIONALE, AIMS AND OBJECTIVES: In rheumatic disorders, one of the treatment objectives is to improve the patient's quality of life (QoL). Similar to other chronic conditions, drug compliance is poor, but necessary for successful treatment. The relationship between drug compliance and QoL has never been tested. The aim of this study was to elucidate the relationship between drug compliance and QoL in patients with different rheumatic disorders. METHOD: A cross-sectional study was conducted and patients ≥18 years of age with rheumatoid arthritis (RA), spondyloarthritis (SA), juvenile idiopathic arthritis (JIA) and systemic scleroderma (SSc) were recruited...
October 2015: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/26078691/treatment-in-juvenile-rheumatoid-arthritis-and-new-treatment-options
#17
REVIEW
Özgür Kasapçopur, Kenan Barut
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of the childhood with the highest risk of disability. Active disease persists in the adulthood in a significant portion of children with juvenile rheumatoid arthritis despite many developments in the diagnosis and treatment. Therefore, initiation of efficient treatment in the early period of the disease may provide faster control of the inflammation and prevention of long-term harms. In recent years, treatment options have also increased in children with juvenile idiopathic arthritis owing to biological medications...
March 2015: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/26059273/methods-for-treating-il-6-related-diseases-us2015010554a1-a-patent-evaluation
#18
Young-Won Chin
INTRODUCTION: IL-6 is involved in a variety of diseases such as acute or chronic inflammation and autoimmune diseases, and the modulation of IL-6 level is recognized as an important target. Therefore, the blocking agent of IL-6 receptor (IL-6R), particularly anti-IL-6R antibody, was invented and its clinical efficacy was well resolved. However, it has not been shown that synergistic effects can be achieved by the combination of anti-IL-6R antibody with immunosuppressants. AREAS COVERED: This patent assessed the possible use of anti-IL-6R antibody (tocilizumab) plus methotrexate (MTX) for the treatment of acute or chronic inflammatory diseases and autoimmune diseases including nephritis, Crohn's disease, ulcerative colitis, pancreatitis, juvenile idiopathic arthritis, rheumatoid arthritis, and psoriasis...
2015: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/26058550/clinical-trial-development-for-biosimilars
#19
REVIEW
Rieke Alten, Bruce N Cronstein
OBJECTIVES: Discuss issues regarding clinical trial design for the development of biosimilars in the European Union and the United States, with special focus on monoclonal antibodies used in the treatment of inflammatory diseases. METHODS: A search of the Internet as well as PubMed was conducted through June 2014 for information related to the clinical development of biosimilars using the keywords biosimilar, rheumatoid arthritis, juvenile idiopathic arthritis, psoriasis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and ankylosing spondylitis...
June 2015: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/26034472/new-onset-aggravation-and-recurrence-of-crohn-s-disease-upon-treatment-with-three-different-tumor-necrosis-factor-inhibitors
#20
Jonas Zeitz, Susann Enderlin, Luc Biedermann, Matthias Turina, Sebastian Leibl, Meher Prakash, Gerhard Rogler, Benjamin Misselwitz
Tumor necrosis factor (TNF) is a major cytokine in the pathogenesis of inflammatory bowel disease (IBD), and TNF inhibition is a cornerstone of contemporary IBD therapy. However, paradoxical induction of IBD has recently been reported upon treatment of rheumatologic disorders with TNF inhibitors. In previous cases, induction of IBD was associated with one single drug and IBD was successfully managed by switching TNF inhibitors. We report the case of a patient with juvenile rheumatoid arthritis under long-term treatment with etanercept...
January 2015: Case Reports in Gastroenterology
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