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Undifferenciated connective tissue disease

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https://www.readbyqxmd.com/read/12610426/-anti-ssa-ro-and-anti-ssb-la-antibodies-what-s-new
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REVIEW
Olivier Meyer
Anti-SSA/Ro and anti-SSB/La autoantibodies recognize different epitopes on polypeptides associated with small RNAs called scYRNA situated mostly in the cytoplasmic compartment (70%) and few in the nuclear compartment (30%). These hYRNPs (h=human) can be found on the cytoplasmic membrane or in small blebs during apoptosis after various stimuli such as UVB, 17-beta-estradiol, viral infection, TNF alpha and other cellular apoptosis inducing molecules. At least two major different proteins are called SSA/Ro: a 52 kDa Ro (with two subtypes alpha and beta) and a 60 kDa Ro...
December 2002: Annales de M├ędecine Interne
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