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Intercalated disc

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https://www.readbyqxmd.com/read/27889952/effects-of-different-doses-of-2-3-dimercaptosuccinic-acid-modified-fe2-o3-nanoparticles-on-intercalated-discs-in-engineered-cardiac-tissues
#1
Yongchao Mou, Shuanghong Lv, Fei Xiong, Yao Han, Yuwei Zhao, Junjie Li, Ning Gu, Jin Zhou
Although iron oxide nanoparticles (IRONs) were applied in clinical magnetic resonance imaging in vivo and magnetic tissue engineering in vitro widely, the underlying effects of IRONs on the development of cardiomyocytes especially the intercellular junctions, intercalated discs (IDs), remain an unknown issue. Given the critical role of three-dimensional (3D) engineered cardiac tissues (ECTs) in evaluation of nanoparticles toxicology, it remained necessary to understand the effects of IRONs on IDs assembly of cardiomyocytes in 3D environment...
November 27, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27769942/carbon-nanotube-composite-hydrogels-promote-intercalated-disc-assembly-in-engineered-cardiac-tissues-through-%C3%AE-1-integrin-mediated-fak-and-rhoa-pathway
#2
Hongyu Sun, Jiajia Tang, Yongchao Mou, Jing Zhou, Linlin Qu, Kayla Duval, Zhu Huang, Ning Lin, Ruiwu Dai, Chengxiao Liang, Zi Chen, Lijun Tang, Fuzhou Tian
: Carbon nanotube (CNT)-based hydrogels have been shown to support cardiomyocyte growth and function. However, their role in cellular integrity among cardiomyocytes has not been studied in detail and the mechanisms underlying this process remain unclear. Here, single walled CNTs incorporated into gelatin with methacrylate anhydride (CNT/GelMA) hydrogels were utilized to construct cardiac tissues, which enhanced cardiomyocyte adhesion and maturation. Furthermore, through the use of immunohistochemical staining, transmission electron microscopy and intracellular calcium transient measurement, the incorporation of CNTs into the scaffolds was observed to markedly enhance the assembly and formation in the cardiac constructs...
October 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27769725/structural-and-molecular-pathology-of%C3%A2-the%C3%A2-atrium-in-boxer-arrhythmogenic-right-ventricular-cardiomyopathy
#3
J Vila, R Pariaut, N S Moïse, E M Oxford, P R Fox, C A Reynolds, C Saelinger
OBJECTIVE: To investigate the expression and distribution of desmosomal and gap junction proteins of the intercalated disc in the atria of boxers with arrhythmogenic right ventricular cardiomyopathy (ARVC). ANIMALS: Nineteen control dogs and 13 boxers with histopathologically confirmed ARVC. METHODS: Right and left atrial samples were examined using immunofluorescence and Western blots. The intercalated disc proteins investigated included total and phosphorylated connexin43 (Cx43 and pCx43), connexin45, connexin40, plakoglobin, plakophilin-2, desmoplakin, and N-cadherin...
October 18, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27742062/isolated-left-ventricular-arrhythmogenic-cardiomyopathy-a-case-report
#4
Raimundo Barbosa-Barros, Andrés Ricardo Pérez-Riera, Luiz Carlos de Abreu, Ricardo Paulo de Sousa-Rocha, Danielli Oliveira da Costa Lino, Adrian Baranchuk, Li Zhang
Left ventricular involvement in the advanced stage of arrhythmogenic cardiomyopathy (AC) is an evolution of this desmosomopathy. Mutation in intercalated discs explains the phenotypic variability. Abnormal trafficking of the intercalated discs at the site of end-to-end contacts between cardiomyocytes and the canonical Wnt/β-catenin and Hippo signaling pathways have been implicated. In AC, T-wave inversion in lateral leads is the hallmark of left ventricular (LV) involvement. We herein report a case of isolated LV AC in which the initial ECG has typical features: fragmented QRS (fQRS), Twave inversion (TWI) in lateral leads, and ventricular tachycardia from inferobasal LV wall...
September 8, 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27723133/aunp-collagen-matrix-with-localized-stiffness-for-cardiac-tissue-engineering-enhancing-the-assembly-of-intercalated-discs-by-%C3%AE-1-integrin-mediated-signaling
#5
Yi Li, Xiaoli Shi, Lei Tian, Hongyu Sun, Yujing Wu, Xia Li, Jianjun Li, Yujie Wei, Xinxiao Han, Jiao Zhang, Xiaowei Jia, Rui Bai, Limin Jing, Peng Ding, Huiliang Liu, Dong Han
A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c.
October 10, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27715000/hybrid-n-alkylamine-intercalated-layered-titanates-for-solid-lubrication
#6
Pablo Gonzalez Rodriguez, Huiyu Yuan, Karin J H van den Nieuwenhuijzen, Walter Lette, Dik J Schipper, Johan E Ten Elshof
The intercalation of different primary n-alkylamines in the structure of a layered titanate of the lepidocrocite type (H1.07Ti1.73O4) for application in high temperature solid lubrication is reported. The intercalation process of the amines was explored by means of in-situ small angle X-ray scattering (SAXS), with variations in alkyl chain length (3 - 12 carbon atoms) and the ratio amine : titanate. The intercalation process was found to be completed within 5 min after mixing of the precursors in water at 80 °C...
October 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27686667/characterization-of-the-functional-and-anatomical-differences-in-the-atrial-and-ventricular-myocardium-from-three-species-of-elasmobranch-fishes-smooth-dogfish-mustelus-canis-sandbar-shark-carcharhinus-plumbeus-and-clearnose-skate-raja-eglanteria
#7
Julie Larsen, Peter Bushnell, John Steffensen, Morten Pedersen, Klaus Qvortrup, Richard Brill
We assessed the functional properties in atrial and ventricular myocardium (using isolated cardiac strips) of smooth dogfish (Mustelus canis), clearnose skate (Raja eglanteria), and sandbar shark (Carcharhinus plumbeus) by blocking Ca(2+) release from the sarcoplasmic reticulum (SR) with ryanodine and thapsigargin and measuring the resultant changes in contraction-relaxation parameters and the force-frequency relationship at 20 °C and 30 °C. We also examined ultrastructural differences with electron microscopy...
September 29, 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/27639425/sarcomeric-lesions-and-remodeling-proximal-to-intercalated-disks-in-overload-induced-cardiac-hypertrophy
#8
Sied Kebir, Zacharias Orfanos, Julia Schuld, Markus Linhart, Christian Lamberz, Peter F M van der Ven, Jan Schrickel, Gregor Kirfel, Dieter O Fürst, Rainer Meyer
Pressure overload induces cardiac remodeling involving both the contractile machinery and intercalated disks (IDs). Filamin C (FlnC) and Xin actin-binding repeat-containing proteins (XIRPs) are multi-adapters localizing in IDs of higher vertebrates. Knockout of the gene encoding Xin (Xirp1) in mice leads to a mild cardiac phenotype with ID mislocalization. In order to amplify this phenotype, we performed transverse aortic constriction (TAC) on control and Xirp1-deficient mice. TAC induced similar left ventricular hypertrophy in both genotypes, suggesting that the lack of Xin does not lead to higher susceptibility to cardiac overload...
October 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27617087/arrhythmogenic-cardiomyopathy-electrical-and-structural-phenotypes
#9
Deniz Akdis, Corinna Brunckhorst, Firat Duru, Ardan M Saguner
This overview gives an update on the molecular mechanisms, clinical manifestations, diagnosis and therapy of arrhythmogenic cardiomyopathy (ACM). ACM is mostly hereditary and associated with mutations in genes encoding proteins of the intercalated disc. Three subtypes have been proposed: the classical right-dominant subtype generally referred to as ARVC/D, biventricular forms with early biventricular involvement and left-dominant subtypes with predominant LV involvement. Typical symptoms include palpitations, arrhythmic (pre)syncope and sudden cardiac arrest due to ventricular arrhythmias, which typically occur in athletes...
August 2016: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/27561386/bubr1-insufficiency-impairs-liver-regeneration-in-aged-mice-after-hepatectomy-through-intercalated-disc-abnormality
#10
Ayae Ikawa-Yoshida, Takuya Matsumoto, Shinji Okano, Yukihiko Aoyagi, Yutaka Matsubara, Tadashi Furuyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mitsuho Onimaru, Tomoko Ohkusa, Masatoshi Nomura, Yoshihiko Maehara
A delay in liver regeneration after partial hepatectomy (PHx) leads to acute liver injury, and such delays are frequently observed in aged patients. BubR1 (budding uninhibited by benzimidazole-related 1) controls chromosome mitotic segregation through the spindle assembly checkpoint, and BubR1 down-regulation promotes aging-associated phenotypes. In this study we investigated the effects of BubR1 insufficiency on liver regeneration in mice. Low-BubR1-expressing mutant (BubR1(L/L)) mice had a delayed recovery of the liver weight-to-body weight ratio and increased liver deviation enzyme levels after PHx...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27510622/potassium-channels-in-the-cx43-gap-junction-perinexus-modulate-ephaptic-coupling-an-experimental-and-modeling-study
#11
Rengasayee Veeraraghavan, Joyce Lin, James P Keener, Robert Gourdie, Steven Poelzing
It was recently demonstrated that cardiac sodium channels (Nav1.5) localized at the perinexus, an intercalated disc (ID) nanodomain associated with gap junctions (GJ), may contribute to electrical coupling between cardiac myocytes via an ephaptic mechanism. Impairment of ephaptic coupling by acute interstitial edema (AIE)-induced swelling of the perinexus was associated with arrhythmogenic, anisotropic conduction slowing. Given that Kir2.1 has also recently been reported to localize at intercalated discs, we hypothesized that Kir2...
October 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27503891/differential-lipid-binding-of-vinculin-isoforms-promotes-quasi-equivalent-dimerization
#12
Krishna Chinthalapudi, Erumbi S Rangarajan, David T Brown, Tina Izard
The main cause of death globally remains debilitating heart conditions, such as dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), which are often due to mutations of specific components of adhesion complexes. Vinculin regulates these complexes and plays essential roles in intercalated discs that are necessary for muscle cell function and coordinated movement and in the development and function of the heart. Humans bearing familial or sporadic mutations in vinculin suffer from chronic, progressively debilitating DCM that ultimately leads to cardiac failure and death, whereas autosomal dominant mutations in vinculin can also provoke HCM, causing acute cardiac failure...
August 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27423584/the-significance-of-intercalated-discs-in-the-pathogenesis-of-friedreich-cardiomyopathy
#13
Arnulf H Koeppen, Alyssa B Becker, Paul J Feustel, Benjamin B Gelman, Joseph E Mazurkiewicz
Friedreich ataxia (FRDA) is an autosomal recessive disorder with a complex clinical and neuropathological phenotype, but the most frequent cause of death is cardiomyopathy. The principal autopsy findings in FRDA hearts are concentric hypertrophy, enlargement of cardiomyocytes, myofiber necrosis, inflammatory infiltration, scarring, and random accumulation of iron. In addition, the myocardium shows generalized disorganization of intercalated discs (ICD), the Velcro-like end-to-end connections of heart fibers that provide mechanical cohesion and ionic coupling...
August 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27364017/lateral-membrane-specific-maguk-cask-down-regulates-nav1-5-channel-in-cardiac-myocytes
#14
Catherine A Eichel, Adeline Beuriot, Morgan Y E Chevalier, Jean-Sébastien Rougier, Florent Louault, Gilles Dilanian, Julien Amour, Alain Coulombe, Hugues Abriel, Stéphane N Hatem, Elise Balse
RATIONALE: Mechanisms underlying membrane protein localization are crucial in the proper function of cardiac myocytes. The main cardiac sodium channel, NaV1.5, carries the sodium current (INa) that provides a rapid depolarizing current during the upstroke of the action potential. Although enriched in the intercalated disc, NaV1.5 is present in different membrane domains in myocytes and interacts with several partners. OBJECTIVE: To test the hypothesis that the MAGUK (membrane-associated guanylate kinase) protein CASK (calcium/calmodulin-dependent serine protein kinase) interacts with and regulates NaV1...
August 5, 2016: Circulation Research
https://www.readbyqxmd.com/read/27362651/regulating-mechanical-tension-at-compartment-boundaries-in-drosophila
#15
Marcus Michel, Christian Dahmann
During animal development, cells with similar function and fate often stay together and sort out from cells with different fates. In Drosophila wing imaginal discs, cells of anterior and posterior fates are separated by a straight compartment boundary. Separation of anterior and posterior cells requires the homeodomain-containing protein Engrailed, which is expressed in posterior cells. Engrailed induces the expression of the short-range signaling molecule Hedgehog in posterior cells and confines Hedgehog signal transduction to anterior cells...
October 2016: Fly
https://www.readbyqxmd.com/read/27353086/mlp-and-carp-are-linked-to-chronic-pkc%C3%AE-signalling-in-dilated-cardiomyopathy
#16
Stephan Lange, Katja Gehmlich, Alexander S Lun, Jordan Blondelle, Charlotte Hooper, Nancy D Dalton, Erika A Alvarez, Xiaoyu Zhang, Marie-Louise Bang, Yama A Abassi, Cristobal G Dos Remedios, Kirk L Peterson, Ju Chen, Elisabeth Ehler
MLP (muscle LIM protein)-deficient mice count among the first mouse models for dilated cardiomyopathy (DCM), yet the exact role of MLP in cardiac signalling processes is still enigmatic. Elevated PKCα signalling activity is known to be an important contributor to heart failure. Here we show that MLP directly inhibits the activity of PKCα. In end-stage DCM, PKCα is concentrated at the intercalated disc of cardiomyocytes, where it is sequestered by the adaptor protein CARP in a multiprotein complex together with PLCβ1...
2016: Nature Communications
https://www.readbyqxmd.com/read/27334848/creg1-interacts-with-sec8-to-promote-cardiomyogenic-differentiation-and-cell-cell-adhesion
#17
Jie Liu, Yanmei Qi, Shaohua Li, Shu-Chan Hsu, Siavash Saadat, June Hsu, Saum A Rahimi, Leonard Y Lee, Chenghui Yan, Xiaoxiang Tian, Yanling Han
Understanding the regulation of cell-cell interactions during the formation of compact myocardial structures is important for achieving true cardiac regeneration through enhancing the integration of stem cell-derived cardiomyocytes into the recipient myocardium. In this study, we found that cellular repressor of E1A-stimulated genes 1 (CREG1) is highly expressed in both embryonic and adult hearts. Gain- and loss-of-function analyses demonstrated that CREG1 is required for differentiation of mouse embryonic stem (ES) cell into cardiomyocytes and the formation of cohesive myocardium-like structures in a cell autonomous fashion...
June 22, 2016: Stem Cells
https://www.readbyqxmd.com/read/27329158/sarcoplasmic-reticulum-is-an-intermediary-of-mitochondrial-and-myofibrillar-growth-at-the-intercalated-disc
#18
Pauline M Bennett, Elisabeth Ehler, Amanda J Wilson
In cardiomyocytes columns of intermyofibrillar mitochondria run up to the intercalated disc (ID); half are collinear with those in the neighbouring cell, suggesting coordinated addition of sarcomeres and mitochondria both within and between cells during cardiomyocyte growth. Recent evidence for an association between sarcoplasmic reticulum (SR) and mitochondria indicates that the SR may be an intermediary in this coordinated behaviour. For this reason we have investigated the arrangement of SR and t tubules with respect to mitochondria and myofibrils, particularly at the ID...
June 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27321809/rare-coding-ttn-variants-are-associated-with-electrocardiographic-qt-interval-in-the-general-population
#19
Ashish Kapoor, Kiranmayee Bakshy, Linda Xu, Priyanka Nandakumar, Dongwon Lee, Eric Boerwinkle, Megan L Grove, Dan E Arking, Aravinda Chakravarti
We have shown previously that noncoding variants mapping around a specific set of 170 genes encoding cardiomyocyte intercalated disc (ID) proteins are more enriched for associations with QT interval than observed for genome-wide comparisons. At a false discovery rate (FDR) of 5%, we had identified 28 such ID protein-encoding genes. Here, we assessed whether coding variants at these 28 genes affect QT interval in the general population as well. We used exome sequencing in 4,469 European American (EA) and 1,880 African American (AA) ancestry individuals from the population-based ARIC (Atherosclerosis Risk In Communities) Study cohort to focus on rare (allele frequency <1%) potentially deleterious (nonsynonymous, stop-gain, splice) variants (n = 2,398 for EA; n = 1,693 for AA) and tested their effects on standardized QT interval residuals...
June 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27274810/lmod2-piggybac-mutant-mice-exhibit-dilated-cardiomyopathy
#20
Shuang Li, Kaiqi Mo, Hong Tian, Chen Chu, Shuna Sun, Lei Tian, Sheng Ding, Tong-Ruei Li, Xiaohui Wu, Fang Liu, Zhen Zhang, Tian Xu, Ling V Sun
BACKGROUND: Leiomodin proteins, Lmod1, Lmod2 and Lmod3, are key regulators of the thin filament length in muscles. While Lmod1 is specifically expressed in smooth muscles, both Lmod2 and Lmod3 are expressed in striated muscles including both cardiac and skeletal muscles. We and others have previously shown that Lmod3 mainly function in skeletal muscles and the mutant mice display disorganized sarcomere. Lmod2 protein has been found to act as an actin filament nucleator in both cell-free assays and in cultured rat and chicken cardiomyocytes...
2016: Cell & Bioscience
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