William P Adams, Tristan B Raisch, Yajun Zhao, Rafael Davalos, Sarah Barrett, D Ryan King, Chandra B Bain, Katrina Colucci-Chang, Grace A Blair, Alexandra Hanlon, Alicia Lozano, Rengasayee Veeraraghavan, Xiaoping Wan, Isabelle Deschenes, James W Smyth, Gregory S Hoeker, Robert G Gourdie, Steven Poelzing
BACKGROUND: Cardiac conduction is understood to occur through gap junctions. Recent evidence supports ephaptic coupling as another mechanism of electrical communication in the heart. Conduction via gap junctions predicts a direct relationship between conduction velocity (CV) and bulk extracellular resistance. By contrast, ephaptic theory is premised on the existence of a biphasic relationship between CV and the volume of specialized extracellular clefts within intercalated discs such as the perinexus...
September 29, 2023: Circulation Research