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Craniopharyngioma

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https://www.readbyqxmd.com/read/29344823/long-term-visual-outcomes-of-craniopharyngioma-in-children
#1
Michael J Wan, Michal Zapotocky, Eric Bouffet, Ute Bartels, Abhaya V Kulkarni, James M Drake
Visual function is a critical factor in the diagnosis, monitoring, and prognosis of craniopharyngiomas in children. The aim of this study was to report the long-term visual outcomes in a cohort of pediatric patients with craniopharyngioma. The study design is a retrospective chart review of craniopharyngioma patients from a single tertiary-care pediatric hospital. 59 patients were included in the study. Mean age at presentation was 9.4 years old (range 0.7-18.0 years old). The most common presenting features were headache (76%), nausea/vomiting (32%), and vision loss (31%)...
January 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29343024/-hypopituitarism-mode-in-patients-with-craniopharyngioma-in-relation-to-tumor-growth-pattern
#2
S T Qi, J X Peng, J Pan, J Fan, S C Zhang, Y Liu, Y Bao, B H Qiu, X Y Wu
Objective: To investigate the pituitary hormone changes of patients with craniopharyngioma of different growth patterns during perioperative period and follow up time. Methods: Retrospective studies were performed on 212 cases of primary craniopharyngioma patient who received total tumor excision surgery in our hospital from January 2001 to May 2012. The characteristics of pituitary hormone and associated clinical manifestation during preoperative, perioperative and postoperative periods were analyzed according to the QST surgical classification...
January 2, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29325954/anterior-skull-base-tumor-resection-by-transciliary-supraorbital-keyhole-craniotomy-a-single-institutional-experience
#3
Ya-Jui Lin, Ko-Ting Chen, Cheng-Chi Lee, Cheng-Hong Toh, Tai-Wei Erich Wu, Yin-Cheng Huang, Peng-Wei Hsu, Yu-Jen Lu, Chi-Cheng Chuang, Pin-Yuan Chen, Kuo-Chen Wei
BACKGROUND: The prognosis and recurrence rate following resection of an anterior skull base lesion via transciliary supraorbital keyhole craniotomy depends on residual tumor volume. The extent to which pathology and size of tumor influence the resection rate using this approach is unknown. METHODS: Sixty-two patients underwent a total of 64 operations using the supraorbital keyhole approach in this retrospective study. Meningioma was the most common tumor, followed by pituitary adenoma and craniopharyngioma...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29314661/the-development-of-hypothalamic-obesity-in-craniopharyngioma-patients-a-risk-factor-analysis-in-a-well-defined-cohort
#4
Laura van Iersel, Ruud W H Meijneke, Antoinette Y N Schouten-van Meeteren, Liesbeth Reneman, Maartje M de Win, A S Paul van Trotsenburg, Peter H Bisschop, Martijn J J Finken, W Peter Vandertop, Wouter R van Furth, Hanneke M van Santen
BACKGROUND: Hypothalamic obesity (HO) is a major concern in patients treated for craniopharyngioma (CP). The influence of degree of resection on development of HO, event-free survival (EFS), and neuroendocrine sequelae is an issue of debate. PROCEDURE: A retrospective cohort consisting of all CP patients treated between 2002 and 2012 in two university hospitals was identified. Multivariable logistic regression was used to study the associations between preoperative BMI, age at diagnosis, tumor volume, performed surgical resection, and presence of HO at follow-up...
January 4, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29286573/hypothalamic-involvement-in-craniopharyngioma-implications-for-surgical-radiooncological-and-molecularly-targeted-treatment-strategies
#5
Hermann L Müller
No abstract text is available yet for this article.
December 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29256549/transcranial-approach-to-craniopharyngiomas-review-of-management-and-outcomes
#6
Muhammad Junaid, Syed Sarmad Bukhari, Muhammad Azmat Khan
Craniopharyngiomas are rare tumours of the central nervous system. Their successful treatment is marred by a high rate of recurrence and postoperative complications. Their occurrence is sufficiently rare to merit treatment at specialized high volume centers. We have described our experience with these tumours because we feel that published literature is rare from our region.We treated 7 patients during this period. Their complete history was taken and full neurological examination was performed. Scans included a plain head CT and an MRI scan with contrast...
December 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29248982/a-case-series-of-atypical-features-of-patients-with-biopsy-proven-isolated-igg4-related-hypophysitis-and-normal-serum-igg4-levels
#7
Kevin C J Yuen, Kelley J Moloney, Jennifer U Mercado, Steven Rostad, Brendan J McCullough, Zachary N Litvack, Johnny B Delashaw, Marc R Mayberg
BACKGROUND: IgG4-related hypophysitis is a rare clinical entity that forms part of an emerging group of multi-organ IgG4-related fibrosclerotic systemic diseases. The rare prevalence of the disease, presenting features that overlap with other sellar pathologies, and variable imaging features can make preoperative identification challenging. PURPOSE AND METHODS: We report three cases of isolated IgG4-related hypophysitis with atypical clinical and imaging features that mimicked those of pituitary apoplexy and other sellar lesions...
December 16, 2017: Pituitary
https://www.readbyqxmd.com/read/29245307/radiological-presentation-of-chondromyxoid-fibroma-in-the-sellar-region-a-care-compliant-article-and-literature-review
#8
Shuai Shen, Miao Chen, Rachel Jug, Cheng-Qian Yu, Wan-Lin Zhang, Lian-He Yang, Liang Wang, Juan-Han Yu, Xu-Yong Lin, Hong-Tao Xu, Shuang Ma
RATIONALE: Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm which often occurs in the lower extremities. Little is known about the radiological and histological presentation of CMF in the sellar region. PATIENT CONCERNS: A 16-year-old Asian male presented to the hospital 12 months ago with bilateral diplopia involving right visual fields, intermittent headaches, and dizziness. INTERVENTIONS: After the patient underwent enough examinations, the lesion was surgically removed by curettage...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29239033/what-s-new-in-pituitary-pathology
#9
REVIEW
Sylvia L Asa, Ozgur Mete
The increasing recognition of pituitary disorders and their impact on quality of life and longevity has made understanding of this small gland a subject of paramount importance. Pituitary pathology has seen many significant studies that indicate progress in identification and classification of pituitary lesions, as well as improved management strategies for patients. In this review, we outline six major areas of advances: (i) changes in terminology from 'adenoma' to 'pituitary neuroendocrine tumour'; (ii) reclassification of hormone-negative tumours based on transcription factor expression that defines lineage; (iii) updates in new pathogenetic mechanisms, including those that underlie rare lesions such as X-LAG and pituitary blastoma; (iv) clarification of hypophysitis due to immunotherapy, xanthomatous hypophysitis due to rupture of a Rathke's cleft cyst and IgG4 disease as the cause of inflammatory pseudotumour; (v) the consolidation of pituicytoma variants, including spindle cell oncocytoma and granular cell tumour based on thyroid transcription factor-1 (TTF-1) reactivity; and (vi) the pathogenetic mechanisms that distinguish papillary from adamantinomatous craniopharyngioma...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29232814/in-reply-to-the-letter-to-the-editor-regarding-anatomic-dissection-of-arachnoid-membranes-encircling-the-pituitary-stalk-on-fresh-non-formalin-fixed-specimens-anatomoradiologic-correlations-and-clinical-applications-in-craniopharyngioma-surgery
#10
https://www.readbyqxmd.com/read/29232813/letter-to-the-editor-regarding-anatomic-dissection-of-arachnoid-membranes-encircling-the-pituitary-stalk-on-fresh-non-formalin-fixed-specimens-anatomoradiologic-correlations-and-clinical-applications-in-craniopharyngioma-surgery
#11
https://www.readbyqxmd.com/read/29230635/quality-of-life-and-growth-after-childhood-craniopharyngioma-results-of-the-multinational-trial%C3%A2-kraniopharyngeom-2007
#12
Kerstin Heinks, Svenja Boekhoff, Anika Hoffmann, Monika Warmuth-Metz, Maria Eveslage, Junxiang Peng, Gabriele Calaminus, Hermann L Müller
CONTEXT: Quality of life (QoL) after childhood-onset craniopharyngioma (CP) is frequently impaired due to tumor and/or treatment-related factors such as endocrine deficits and hypothalamic involvement/lesions. PATIENTS AND METHODS: In a multinational trial, we prospectively analyzed parental and self-assessment of CP patient QoL at 3 months, 1 and 3 years after CP diagnosis related to growth hormone (GH) substitution. 47 of 194 CP recruited between 2007 and 2015 in KRANIOPHARYNGEOM 2007 were analyzed for QoL 1 and 3 years after CP diagnosis...
December 11, 2017: Endocrine
https://www.readbyqxmd.com/read/29220529/oxytocin-and-naltrexone-successfully-treat-hypothalamic-obesity-in-a-boy-post-craniopharyngioma-resection
#13
Eugenie A Hsu, Jennifer L Miller, Francisco A Perez, Christian L Roth
Context: Hypothalamic obesity, a treatment-resistant condition common to survivors of craniopharyngioma (CP), is strongly associated with a poor quality of life in this population. Oxytocin (OT), a hypothalamic neuropeptide, has been shown to play a role in the regulation of energy balance and to have anorexigenic effects in animal studies. Naltrexone (NAL), an opiate antagonist, has been shown to deter hedonic eating and to potentiate OT's effects. Case description: In this parent-observed study, we tested the administration of intranasal OT for 10 weeks (phase 1), followed by a combination of intranasal OT and NAL for 38 weeks (phase 2) in a 13-year-old male with confirmed hypothalamic obesity and hyperphagia post-CP resection...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29204195/magnitude-of-neurogenic-tumor-burden-in-pediatric-population-a-tertiary-care-center-study
#14
Shagufta Qadri, Mahboob Hasan, Kafil Akhtar
Objective: Progress in the diagnosis and treatment of childhood neoplasm in the past few decades is one of the most gratifying achievements in the field of oncology. This study was aimed to ascertain the burden (incidence and prevalence) and histopathologic features of neurogenic tumors occurring in the pediatric population. Materials and Methods: The study evaluated a total of 492 cases of pediatric tumors over a period of 8 years from 2007 to 2015, including patients of 0-12 years of age group; attending the out-patients and in-patients Department of Pediatrics and Pediatric Surgery at Jawaharlal Nehru Medical College, AMU, Aligarh, with the complaints of tumor or tumor associated sign and symptoms...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29204019/histologically-confirmed-intracranial-tumors-managed-at-enugu-nigeria
#15
Chika Anele Ndubuisi, Samuel C Ohaegbulam, Linda U Iroegbu, Mike Ezeali Ekuma, Wilfred C Mezue, Uwadiegwu Alphonsus Erechukwu
Background: There is controversy about the global distribution of intracranial tumors (ICTs). The previous reports from Africa suggested low frequency and different pattern of distribution of brain tumors from what obtains in other continents. The limitations at that time, including paucity of diagnostic facilities and personnel, have improved. Objective: The objective of this study is to analyze the current trend and distribution of histology confirmed brain tumors managed in Enugu, in a decade...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29199465/12-years-delayed-postoperative-spinal-recurrence-of-craniopharyngioma-case-report-and-literature-review
#16
Nicolò Marchesini, Christian Soda, Umberto Maria Ricci, Mattia Sedia, Francesco Sala, Giampietro Pinna
A case of delayed spinal adamantinomatous craniopharyngioma recurrence is presented. A 54-year-old male patient was admitted in our Emergency Department complaining of urinary disorders and leg pains. He underwent surgical removal of intraventricular craniopharyngioma 12 years previously. On MR imaging a well-circumscribed intradural cistyc mass at the T12 level was reavealed. A T11 and T12 laminotomy was performed and total removal of the tumour was achieved. Histology examination showed adamantinous craniopharyngioma...
December 4, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29195268/endoscopic-and-microscopic-transsphenoidal-surgery-of-craniopharyngiomas-a-systematic-review-of-surgical-outcomes-over-two-decades
#17
Federico Cagnazzo, Matteo Zoli, Diego Mazzatenta, Jamie J Van Gompel
No abstract text is available yet for this article.
December 1, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29185147/predicting-pituitary-stalk-position-by-in-vivo-visualization-of-the-hypothalamo-hypophyseal-tract-in-craniopharyngioma-using-diffusion-tensor-imaging-tractography
#18
Fuyu Wang, Jinli Jiang, Jiashu Zhang, Qun Wang
The pituitary stalk (PS) is crucial to endocrine function and water-electrolyte equilibrium. Preservation of the PS during craniopharyngioma (CP) surgery is critical; however, in a pathological state, it is difficult to identify. The hypothalamo-hypophyseal tract (HHT) connects the hypothalamus and the posterior pituitary gland and projects through the PS. Thus, visualization of the HHT can help locate the PS. Preoperative visualization of the neural fasciculus has been widely achieved using diffusion tensor imaging (DTI) tractography...
November 28, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29182371/decrease-in-scale-invariance-of-activity-fluctuations-with-aging-and-in-patients-with-suprasellar-tumors
#19
S D Joustra, C Gu, J H T Rohling, L Pickering, M Klose, K Hu, F A Scheer, U Feldt-Rasmussen, P J Jennum, A M Pereira, N R Biermasz, J H Meijer
Motor activity in healthy young humans displays intrinsic fluctuations that are scale-invariant over a wide range of time scales (from minutes to hours). Human postmortem and animal lesion studies showed that the intact function of the suprachiasmatic nucleus (SCN) is required to maintain such scale-invariant patterns. We therefore hypothesized that scale invariance is degraded in patients treated for suprasellar tumors that compress the SCN. To test the hypothesis, we investigated 68 patients with nonfunctioning pituitary macroadenoma and 22 patients with craniopharyngioma, as well as 72 age-matched healthy controls (age range 21...
November 28, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29180744/stem-cell-senescence-drives-age-attenuated-induction-of-pituitary-tumours-in-mouse-models-of-paediatric-craniopharyngioma
#20
Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R Goding, Thomas S Jacques, David J Adams, Jesus Gil, Cynthia L Andoniadou, Juan Pedro Martinez-Barbera
Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2- cells in a paracrine manner. Here, we uncover the mechanisms underlying this paracrine tumourigenesis...
November 28, 2017: Nature Communications
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