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Craniopharyngioma

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https://www.readbyqxmd.com/read/28448550/priority-target-conditions-for-algorithms-for-monitoring-children-s-growth-interdisciplinary-consensus
#1
Pauline Scherdel, Rachel Reynaud, Christine Pietrement, Jean-François Salaün, Marc Bellaïche, Michel Arnould, Bertrand Chevallier, Hugues Piloquet, Emmanuel Jobez, Jacques Cheymol, Emmanuelle Bichara, Barbara Heude, Martin Chalumeau
BACKGROUND: Growth monitoring of apparently healthy children aims at early detection of serious conditions through the use of both clinical expertise and algorithms that define abnormal growth. Optimization of growth monitoring requires standardization of the definition of abnormal growth, and the selection of the priority target conditions is a prerequisite of such standardization. OBJECTIVE: To obtain a consensus about the priority target conditions for algorithms monitoring children's growth...
2017: PloS One
https://www.readbyqxmd.com/read/28443260/growth-without-growth-hormone-in-combined-pituitary-hormone-deficiency-caused-by-pituitary-stalk-interruption-syndrome
#2
Sang Soo Lee, A-Leum Han, Moon Bae Ahn, Shin Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Min Ho Jung, Byung-Kyu Suh
Growth hormone (GH) is an essential element for normal growth. However, reports of normal growth without GH have been made in patients who have undergone brain surgery for craniopharyngioma. Normal growth without GH can be explained by hyperinsulinemia, hyperprolactinemia, elevated leptin levels, and GH variants; however, its exact mechanism has not been elucidated yet. We diagnosed a female patient aged 13 with combined pituitary hormone deficiency (CPHD) caused by pituitary stalk interruption syndrome (PSIS)...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28440760/hypothalamic-obesity-after-craniopharyngioma-surgery-treatment-with-a-long-acting-glucagon-like-peptide-1-derivated
#3
Inés Castro-Dufourny, Rodrigo Carrasco, José María Pascual
No abstract text is available yet for this article.
March 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28433845/clinical-outcome-after-extended-endoscopic-endonasal-resection-of-craniopharyngiomas-two-institution-experience
#4
Hye Ran Park, Varun R Kshettry, Christopher J Farrell, Jae Meen Lee, Yong Hwy Kim, Tae Bin Won, Doo Hee Han, Hyunwoo Do, Gurston Nyguist, Marc Rosen, Dong Gyu Kim, James J Evans, Sun Ha Paek
BACKGROUND: The extended endoscopic endonasal approach (EEA) to the anterior cranial base is used for the resection of craniopharyngiomas. OBJECTIVE: We present clinical experience and outcomes utilizing EEA for craniopharyngiomas. METHODS: A total of 116 patients in two remote institutions were enrolled in this retrospective study. Surgical, endocrinological and ophthalmological outcomes were assessed. RESULTS: The mean follow-up was 35 months (range, 1-115)...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28427982/preoperative-evaluation-of-sellar-and-parasellar-macro-lesions-by-fluorine-18-fluorodeoxyglucose-positron-emission-tomography
#5
Masahiko Tosaka, Tetsuya Higuchi, Keishi Horiguchi, Tadashi Osawa, Yukiko Arisaka, Haruyasu Fujita, Yoshito Tsushima, Yuhei Yoshimoto
OBJECTIVE: Various pathologies can occur in the sellar and suprasellar regions. The potential of fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) for the preoperative evaluation of sellar and parasellar lesions was investigated. METHODS: A total of 49 patients aged 8 to 82 years with sellar and parasellar macroscopic lesions (≥10 mm) underwent FDG PET. Twenty-two patients had pituitary adenomas, including 14 non-functioning and 8 growth hormone (GH)-secreting adenomas...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28425764/braf-v600e-mutant-papillary-craniopharyngioma-dramatically-responds-to-combination-braf-and-mek-inhibitors
#6
Ashley Roque, Yazmin Odia
We present a patient with BRAF-V600E mutant papillary craniopharyngioma successfully treated with combination BRAF (dabrafenib 150 mg twice daily) and MEK (trametinib 2 mg daily) inhibitors after her unresectable tumor proved refractory to radiation. Serial brain MRIs and PET revealed marked tumor reduction with gradual neurological improvement and permanent panhypopituitarism.
April 2017: CNS Oncology
https://www.readbyqxmd.com/read/28414891/genetically-engineered-mouse-models-of-craniopharyngioma-an-opportunity-for-therapy-development-and-understanding-of-tumor-biology
#7
REVIEW
John Richard Apps, Juan Pedro Martinez-Barbera
Adamantinomatous craniopharyngioma (ACP) is the commonest tumor of the sellar region in childhood. Two genetically engineered mouse models have been developed and are giving valuable insights into ACP biology. These models have identified novel pathways activated in tumors, revealed an important function of paracrine signalling and extended conventional theories about the role of organ-specific stem cells in tumorigenesis. In this review, we summarize these mouse models, what has been learnt, their limitations and open questions for future research...
May 2017: Brain Pathology
https://www.readbyqxmd.com/read/28414889/proteomics-in-pediatric-cystic-craniopharyngioma
#8
Luca Massimi, Claudia Martelli, Massimo Caldarelli, Massimo Castagnola, Claudia Desiderio
Adamantinomatous craniopharyngioma (ACP) is still often burdened by a poor prognosis in children as far as the risk of recurrence and the quality of life are concerned. Therefore, many efforts are now dedicated to investigate the molecular characteristics of this tumor aiming at finding new therapeutic options. ACP is prevalently a cystic lesion so that an increasing number of researches are focused on the analysis of its cystic content. In the present article, the main results of the current proteomic analysis (PA) on the ACP fluid are summarized...
May 2017: Brain Pathology
https://www.readbyqxmd.com/read/28414888/models-of-human-adamantinomatous-craniopharyngioma-tissue-steps-toward-an-effective-adjuvant-treatment
#9
Annett Hölsken, Rolf Buslei
Even though ACP is a benign tumor, treatment is challenging because of the tumor's eloquent location. Today, with the exception of surgical intervention and irradiation, further treatment options are limited. However, ongoing molecular research in this field provides insights into the pathways involved in ACP pathogenesis and reveal a plethora of druggable targets. In the next step, appropriate models are essential to identify the most suitable and effective substances for clinical practice. Primary cell cultures in low passages provide a proper and rapid tool for initial drug potency testing...
May 2017: Brain Pathology
https://www.readbyqxmd.com/read/28413554/confounding-features-of-ectopic-craniopharyngioma-a-differential-for-tumors-showing-diffusion-restriction
#10
Sudha Karnan, Vanitha Krishnamoorthy, Kailasanathan Natarajan, Babu Peter Sathyanathan
Craniopharyngiomas comprise approximately 1-3% of all intracranial tumors and arise from squamous epithelial rests along remnants of Rathke's cleft. They have bimodal age distribution. The ectopic sites reported are the nasopharynx, sphenoid bone, pineal region, cerebellopontine angle and third ventricle. We report a case of ectopic craniopharyngioma in the Foramen of Monro with restricted diffusion, which have is an unusual feature, not commonly reported and is a potential pitfall.
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28403130/primary-ectopic-ethmoidal-craniopharyngioma
#11
Andrea Preti, Apostolos Karligkiotis, Carla Facco, Giorgia Ottini, Luca Volpi, Paolo Castelnuovo
Craniopharyngiomas are benign but aggressive epithelial tumors usually originating in the anterior lobe of the pituitary gland from squamous remnants of an incompletely involuted craniopharingeal duct developing from the Rathke pouch. To the authors' knowledge only 1 patient of a primary isolated ethmoidal craniopharyngioma has been reported in the literature.The authors report the case of a 17-year-old boy with a primary extracranial ethmoidal craniopharyngioma. An endoscopic endonasal approach was employed to resect the tumor...
April 11, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28396614/can-takotsubo-cardiomyopathy-be-diagnosed-by-autopsy-report-of-a-presumed-case-presenting-as-cardiac-rupture
#12
Andrew Mitchell, François Marquis
BACKGROUND: Takostsubo (stress) cardiomyopathy (TC) is a clinical syndrome featuring transient left ventricular dysfunction and wall-motion abnormalities, usually following emotional or physical stress. The diagnosis of TC depends on fulfillment of multiple clinical criteria. Although the pathogenesis has not been firmly established, myocardial cathecholamine toxicity is thought to represent a primary mechanism. The vast majority of patients with TC survive. However, a rare cause of death in TC is myocardial rupture...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28395087/retrospective-analysis-of-molecular-and-immunohistochemical-characterization-of-381-primary-brain-tumors
#13
Leomar Y Ballester, Gregory N Fuller, Suzanne Z Powell, Erik P Sulman, Keyur P Patel, Rajyalakshmi Luthra, Mark J Routbort
The classification of brain tumors has traditionally depended on microscopic examination of hematoxylin and eosin-stained tissue sections. The increased understanding of clinically relevant genetic alterations has led to the incorporation of molecular signatures as part of the diagnosis of brain malignancies. Advances in sequencing technologies have facilitated the use of next-generation sequencing (NGS) assays in clinical laboratories. We performed a retrospective analysis of sequencing results for 381 brain tumors tested by NGS at our institution using a validated, commercially available panel...
March 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28389503/the-purine-receptor-p2x7r-regulates-release-of-pro-inflammatory-cytokines-in-human-craniopharyngioma
#14
Jing Nie, Guanglong Huang, Shengze Deng, Yun Bao, Yawei Liu, Zhanpeng Feng, Chaohu Wang, Ming Chen, Songtao Qi, Jun Pan
Craniopharyngiomas (CPs) are usually benign, non-metastasizing embryonic malformations originating from the sellar area. They are, however, locally invasive and generate adherent interfaces with the surrounding brain parenchyma. Previous studies have shown the tumor microenvironment is characterized by a local abundance of Adenosine Triphosphate (ATP), infiltration of leukocytes, and elevated levels of pro-inflammatory cytokines that are thought to be responsible, at least in part, for the local invasion. Here we examine whether ATP, via the P2X7R, participates in the regulation of cytokine expression in CPs...
April 7, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28359095/radiotherapy-especially-at-young-age-increases-the-risk-for-de-novo-brain-tumors-in-patients-treated-for-pituitary-sellar-lesions
#15
Pia Burman, André P van Beek, Beverly M K Biller, Cecilia Camacho-Hübner, Anders F Mattsson
Context: De novo brain tumors developing after treatment of pituitary/sellar lesions have been reported, but it is unknown whether this is linked to any of the treatment modalities. Objective: To study the occurrence of malignant brain tumors and meningiomas in a large cohort of patients treated for pituitary/sellar lesions, with special emphasis on the role of radiotherapy (RT). Patients and Methods: Patients (n = 8917) who were hypopituitary due to pituitary adenomas, craniopharyngiomas, and other sellar tumors followed in KIMS (Pfizer International Metabolic Database) from 1994 to 2012 were included...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28344177/multi-modality-multi-directional-resection-of-craniopharyngioma-versatility-in-alternating-the-principal-and-auxiliary-surgical-corridors-and-visualization-modalities
#16
https://www.readbyqxmd.com/read/28337609/trans-eyebrow-supraorbital-approach-in-large-suprasellar-craniopharyngioma-surgery-in-adults-analysis-of-optic-nerve-length-and-extent-of-tumor-resection-original-article
#17
Ricardo Prat, Inma Galeano, Rocío Evangelista, Giovanni Pancucci, Juliana Guarín, Angel Ayuso, Mukesh Misra
BACKGROUND: One of the main drawbacks in the surgery of large craniopharyngiomas is the presence of a prefixed optic chiasm. Our main objective in this study is to compare the predictive value of the optic nerve length and optic chiasm location on large craniopharyngiomas' extent of resection. METHOD: We retrospectively studied 21 consecutive patients with large craniopharyngiomas who underwent tumor resection through the trans-eyebrow supraorbital approach. Clinical and radiological findings on preoperative MRI were recorded, including the optic chiasm location classified as prefixed, postfixed or normal...
May 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28327937/commentary-cystic-craniopharyngiomas-microsurgical-or-stereotactic-treatment
#18
Peter C Warnke
No abstract text is available yet for this article.
March 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28325825/very-long-term-sequelae-of-craniopharyngioma
#19
Mark Wijnen, Marry M van den Heuvel-Eibrink, Joseph A M J L Janssen, Coriene E Catsman-Berrevoets, Erna M C Michiels, Marie-Lise C van Veelen-Vincent, Alof H G Dallenga, Jan H van den Berge, Carolien M van Rij, A J Van der Lely, Sebastian J C M M Neggers
OBJECTIVE: Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and do generally not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation...
March 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28324187/frontal-burr-hole-approach-for-neuroendoscopic-resection-of-craniopharyngioma-with-the-nico-myriad-device-report-of-two-cases
#20
Reilin J Moore, Andrea Scherer, Daniel H Fulkerson
OBJECTIVE: Craniopharyngiomas are challenging tumors to resect due to their deep location and proximity to vital structures. The perceived benefit of gross total resection may be tempered by the possibility of permanent disability. Minimally invasive techniques may reduce surgical morbidity while still allowing effective resection. The authors describe their initial experience with a neuroendoscopic transcortical, transventricular approach to two craniopharyngiomas. The surgeries were performed through a right frontal burr hole using the NICO Myriad, a side-cutting, aspiration device that fits through the working channel of a standard neuroendoscope...
April 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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