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Craniopharyngioma

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https://www.readbyqxmd.com/read/28613044/for-debate-should-bariatric-surgery-be-performed-in-children-and-adolescents-with-hypothalamic-obesity
#1
EDITORIAL
Sarka Stolbova, Marek Benes, Lenka Petruzelkova, Jan Lebl, Stanislava Kolouskova
Hypothalamic dysfunction leading to severe obesity is a serious long-term consequence of paediatric craniopharyngioma. It compromises quality of life, leads to long-term metabolic hazards, and may shorten life expectancy. Therefore, a proactive approach is required. Conventional treatment of hypothalamic obesity is difficult and hardly successful. Experience with bariatric surgery is limited, especially in younger patients. Two retrospective studies recently reported on classic bariatric surgery in a small series of individuals after craniopharyngioma...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28604190/the-use-of-a-stent-retriever-to-cause-mechanical-dilatation-of-a-vasospasm-secondary-to-iatrogenic-subarachnoid-haemorrhage
#2
Pervinder Bhogal, Dimitris Paraskevopoulos, Hegoda Ld Makalanda
Objective To report the use of a stent-retriever in the management of vasospasm secondary to craniopharyngioma resection. Postoperative improvement was seen both clinically and on perfusion imaging. Methods A patient was admitted for resection of a large craniopharygioma. On day 6 postoperatively the patient had an acute hemiparesis. A computed tomography angiogram and perfusion scan demonstrated acute right-sided cerebral vasospasm and a perfusion defect in the territory of the middle cerebral artery (MCA)...
June 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28593552/a-reformed-surgical-treatment-modality-for-children-with-giant-cystic-craniopharyngioma
#3
Wanchun Zhu, Xiang Li, Jintao He, Tao Sun, Chunde Li, Jian Gong
OBJECTIVE: Surgical removal plays an important role in treating children's craniopharyngioma. For a safe and minimally invasive craniotomy, a reformed surgical modality was proposed in this paper by combining the insertion of an Ommaya reservoir system (ORS) by stereotactic puncture, aspiration of cystic fluid in 2-day interval for consecutive 7-10 days, and the delayed tumor resection. PATIENTS AND METHODS: Eleven patients (aged from 5 to 9 years old) with giant cystic craniopharyngiomas who had undergone the reformed surgical modality during November 2014 and December 2015 were collected as group A...
June 7, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28593109/extent-of-endoscopic-resection-for-anterior-skull-base-tumors-an-mri-based-volumetric-analysis
#4
Ian J Koszewski, Gregory Avey, Azam Ahmed, Lucas Leonhard, Matthew R Hoffman, Timothy M McCulloch
Objective  To determine the volume of ventral skull base tumor removed following endoscopic endonasal (EEA) resection using MRI-based volumetric analysis and to evaluate the inter-rater reliability of such analysis. Design  Retrospective case series. Setting  Academic tertiary care hospital. Participants  EEA patients November 2012 to August 2015. Main Outcome Measures  Volumetric analysis of pre- and immediately postoperative MR imaging was performed independently by two investigators. The percentage of total tumor resected was evaluated according to resection goal and tumor type...
June 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28588668/fluid-fluid-level-on-magnetic-resonance-images-may-predict-the-occurrence-of-pituitary-adenomas-in-cystic-sellar-suprasellar-masses
#5
Deyong Xiao, Shousen Wang, Lin Zhao, Qun Zhong, Yinxing Huang, Chenyu Ding
The aim of the present study was to evaluate the value of identifying fluid-fluid level via preoperative magnetic resonance (MR) images in differentiating pituitary adenomas from craniopharyngioma, Rathke's cleft cyst (RCC), and other cystic sellar-suprasellar lesions. The data of 293 consecutive patients who underwent surgery for sellar-suprasellar lesions between July 2010 and December 2012 was retrospectively reviewed, and a total of 133 cystic cases were included in the present study. MR images and pathological features of all subjects were examined...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28587427/mri-features-of-growth-hormone-deficiency-in-children-with-short-stature-caused-by-pituitary-lesions
#6
Chao Xu, Xinxian Zhang, Lina Dong, Bin Zhu, Tao Xin
We verified the advantages of using magnetic resonance imaging (MRI) for improving the diagnostic quality of growth hormone deficiency (GHD) in children with short stature caused by pituitary lesions. Clinical data obtained from 577 GHD patients with short stature caused by pituitary lesions were retrospectively analyzed. There were 354 cases (61.3%) with anterior pituitary dysplasia; 45 cases (7.8%) of pituitary stalk interruption syndrome (PSIS); 15 cases (2.6%) of pituitary hyperplasia due to primary hypothyroidism; 38 cases (6...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28574307/korsakoff-syndrome-from-retrochiasmatic-suprasellar-lesions-rapid-reversal-after-relief-of-cerebral-compression-in-4-cases
#7
Luis E Savastano, Todd C Hollon, Ariel L Barkan, Stephen E Sullivan
Korsakoff syndrome is a chronic memory disorder caused by a severe deficiency of thiamine that is most commonly observed in alcoholics. However, some have proposed that focal structural lesions disrupting memory circuits-in particular, the mammillary bodies, the mammillothalamic tract, and the anterior thalamus-can give rise to this amnestic syndrome. Here, the authors present 4 patients with reversible Korsakoff syndromes caused by suprasellar retrochiasmatic lesions compressing the mammillary bodies and adjacent caudal hypothalamic structures...
June 2, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28550628/giovanni-verga-1879-1923-author-of-a-pioneering-treatise-on-pituitary-surgery-the-foundations-of-this-new-field-in-europe-in-the-early-1900s
#8
REVIEW
José M Pascual, Lorenzo Mongardi, Ruth Prieto, Inés Castro-Dufourny, María Rosdolsky, Sewan Strauss, Rodrigo Carrasco, Eduard Winter, Paolo Mazzarello
The field of pituitary surgery was born in the first decade of the twentieth century in Europe, and it evolved rapidly with the development of numerous innovative surgical techniques by some of the founding fathers of neurosurgery. This study investigates the pioneering Italian treatise on pituitary surgery, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), published in 1911 by Giovanni Verga (1879-1923), a surgeon from Pavía and one of Golgi's disciples. This little-known monograph compiles the earliest experience on pituitary surgery through the analysis of the first 50 procedures performed between 1903 and 1911...
May 27, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28544746/clinical-outcomes-following-proton-therapy-for-children-with-central-nervous-system-tumors-referred-overseas
#9
Daniel J Indelicato, Julie A Bradley, Eric S Sandler, Philipp R Aldana, Amy Sapp, Jennifer E Gains, Adrian Crellin, Ronny L Rotondo
BACKGROUND: International, multidisciplinary care of children with central nervous system (CNS) tumors presents unique challenges. The aim of this study is to report patient outcomes of U.K. children referred for proton therapy to a North American facility. METHODS: From 2008 to 2016, 166 U.K. children with approved CNS tumors were treated with proton therapy at a single academic medical center in the United States. Median age was 7 years (range, 1-19). Median follow-up was 2...
May 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28540667/neurocognitive-functioning-in-pediatric-craniopharyngioma-performance-before-treatment-with-proton-therapy
#10
Ashley S Fournier-Goodnight, Jason M Ashford, Thomas E Merchant, Frederick A Boop, Daniel J Indelicato, Lei Wang, Hui Zhang, Heather M Conklin
The goal of this study was to investigate the impact of patient-, disease-, and treatment-related variables upon neurocognitive outcomes in pediatric patients with craniopharyngioma prior to treatment with proton therapy or observation after radical resection. For all participants (N = 104), relevant clinical and demographic variables were attained and neurocognitive evaluations completed prior to irradiation or planned observation. One-sample t-tests were conducted to compare performance to published normative data...
May 24, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28516074/an-updated-nationwide-epidemiology-of-primary-brain-tumors-in-republic-of-korea-2013
#11
Yun-Sik Dho, Kyu-Won Jung, Johyun Ha, Youngbeom Seo, Chul-Kee Park, Young-Joo Won, Heon Yoo
BACKGROUND: This report aims to provide accurate nationwide epidemiologic data on primary brain and central nervous system (CNS) tumors in the Republic of Korea. We updated the data by analyzing primary brain and CNS tumors diagnosed in 2013 using the data from the national cancer incidence database. METHODS: Data on primary brain and CNS tumors diagnosed in 2013 were collected from the Korean Central Cancer Registry. Crude and age-standardized rates were calculated in terms of gender, age, and histological type...
April 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/28511971/learning-curve-for-the-endoscopic-endonasal-approach-for-suprasellar-craniopharyngiomas
#12
Hailin Ding, Ye Gu, Xiaobiao Zhang, Tao Xie, Tengfei Liu, Fan Hu, Yong Yu, Chongjing Sun
The endoscopic endonasal approach is considered an alternative minimally invasive approach for suprasellar craniopharyngiomas. However, the complicated surgical manipulations required by this approach have limited its application. We evaluate whether the approach features a learning curve. Thirty-three patients were retrospectively reviewed and grouped as early (17 patients) and late (16 patient) groups. The operation time, extent of removal, ophthalmology, endocrinology, reconstruction and modifications of standard technique were evaluated...
May 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28508600/endocrine-disorders-developing-after-surgical-intervention-of-craniopharyngioma-in-children
#13
Kyrillus S Shohdy, Wegdan Rashad
Craniopharyngiomas, albeit their benign nature, can cause severe damage to visual, hypothalamic, endocrine and neurologic functions which make their total resection an inevitable approach to save the patient's life. However, significant therapy-related long term complications make those traditional treatment options debatable and hazardous. This review will focus on the various complications that affect the childrens' quality of life considerably such as, diabetes insipidus, precocious puberty and hypothalamic obesity...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28506993/mapk-pathway-control-of-stem-cell-proliferation-and-differentiation-in-the-embryonic-pituitary-provides-insights-into-the-pathogenesis-of-papillary-craniopharyngioma
#14
Scott Haston, Sara Pozzi, Gabriela Carreno, Saba Manshaei, Leonidas Panousopoulos, Jose Mario Gonzalez-Meljem, John R Apps, Alex Virasami, Selvam Thavaraj, Alice Gutteridge, Tim Forshew, Richard Marais, Sebastian Brandner, Thomas S Jacques, Cynthia L Andoniadou, Juan Pedro Martinez-Barbera
Despite the importance of the RAS-RAF-MAPK pathway in normal physiology and disease of numerous organs, its role during pituitary development and tumourigenesis remains largely unknown. Here, we show that the over-activation of the MAPK pathway, through conditional expression of the gain-of-function alleles BrafV600E and KrasG12D in the developing mouse pituitary, results in severe hyperplasia and abnormal morphogenesis of the gland by the end of gestation. Cell-lineage commitment and terminal differentiation are disrupted, leading to a significant reduction in numbers of most of the hormone-producing cells before birth, with the exception of corticotrophs...
June 15, 2017: Development
https://www.readbyqxmd.com/read/28502079/microstructure-alterations-in-the-hypothalamus-in-cranially-radiated-childhood-leukemia-survivors-but-not-in-craniopharyngioma-patients-unaffected-by-hypothalamic-damage
#15
Cecilia Follin, Sigridur Fjalldal, Daniel Svärd, Danielle van Westen, Sanaz Gabery, Åsa Petersén, Jimmy Lätt, Lars Rylander, Eva Marie Erfurth
OBJECTIVE: Metabolic complications are frequent in childhood leukemia (ALL) survivors treated with cranial radiotherapy (CRT). These complications are potentially mediated by damage to the hypothalamus (HT), as childhood onset (CO) craniopharyngioma (CP) survivors without HT involvement are spared overt obesity. Diffusion tensor imaging (DTI) shows brain tissue microstructure alterations, by fractional anisotrophy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)...
May 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28500561/study-of-%C3%AE-catenin-and-braf-alterations-in-adamantinomatous-and-papillary-craniopharyngiomas-mutation-analysis-with-immunohistochemical-correlation-in-54-cases
#16
Prit Benny Malgulwar, Aruna Nambirajan, Pankaj Pathak, Mohammed Faruq, Vaishali Suri, Chitra Sarkar, Amandeep Jagdevan, Bhawani Shankar Sharma, Mehar Chand Sharma
Craniopharyngiomas (CP) are rare benign epithelial tumors, with two histological variants, namely the adamantinomatous variant (ACP) and the rarer papillary variant (PCP). They are locally infiltrative and surgically challenging tumors with severe long term morbidity. CTNNB1 mutations with β-catenin immunopositivity and BRAFV600E mutations with anti-VE immunopositivity have been recently described in ACPs and PCPs respectively. We aimed to study BRAF and CTNNB1 gene mutations in CPs operated at our institute, and correlate it with clinicopathological parameters including histopathology and immunohistochemistry (IHC) for proteins VE-1 and β-catenin...
May 12, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28499018/intracystic-interferon-alpha-in-pediatric-craniopharyngioma-patients-an-international-multicenter-assessment-on-behalf-of-siope-and-ispn
#17
John-Paul Kilday, Massimo Caldarelli, Luca Massimi, Robert Hsin-Hung Chen, Yi Yen Lee, Muh-Lii Liang, Jeanette Parkes, Thuran Naiker, Marie-Lise van Veelen, Erna Michiels, Conor Mallucci, Benedetta Pettorini, Lisethe Meijer, Christian Dorfer, Thomas Czech, Manuel Diezi, Antoinette Yn Schouten-van Meeteren, Stefan Holm, Bengt Gustavsson, Martin Benesch, Hermann L Müller, Anika Hoffmann, Stefan Rutkowski, Joerg Flitsch, Gabriele Escherich, Michael Grotzer, Helen A Spoudeas, Kristian Azquikina, Michael Capra, Rolando Jiménez-Guerra, Patrick MacDonald, Donna L Johnston, Rina Dvir, Shlomi Constantini, Meng-Fai Kuo, Shih-Hung Yang, Ute Bartels
Background: Craniopharyngiomas are frequent hypothalamo-pituitary tumors in children, presenting predominantly as cystic lesions. Morbidity from conventional treatment has focused attention on intracystic drug delivery, hypothesized to cause fewer clinical consequences. However, the efficacy of intracystic therapy remains unclear. We report the retrospective experiences of several global centers using intracystic interferon-alpha. Methods: European Société Internationale d'Oncologie Pédiatrique and International Society for Pediatric Neurosurgery centers were contacted to submit a datasheet capturing pediatric patients with cystic craniopharyngiomas who had received intracystic interferon-alpha...
May 11, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28488624/papillary-craniopharyngioma-a-clinicopathologic-study-of-a-rare-entity-from-a-major-tertiary-care-center-in-pakistan
#18
Muhammad Usman Tariq, Nasir Ud Din, Zubair Ahmad, Wasim Memon
BACKGROUND: Papillary craniopharyngioma (PCP) are uncommon variants of craniopharyngiomas (CP), which are benign epithelial neoplasms of the sellar and suprasellar region. Histologically, PCPs are typically composed of well-differentiated stratified squamous epithelium; however, focal variations are not uncommon. A distinction from other lesions of the region, despite being difficult to achieve due to the overlapping radiological and clinical features, is important for adequate treatment to be administered...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28487953/interleukin%C3%A2-6-induces-an-epithelial%C3%A2-mesenchymal-transition-phenotype-in-human-adamantinomatous-craniopharyngioma-cells-and-promotes-tumor-cell-migration
#19
Jie Zhou, Chao Zhang, Jun Pan, Ligang Chen, Song-Tao Qi
Total resection of adamantinomatous craniopharyngioma (ACP) is complex and often leads to postoperative recurrence. This is due to the tendency of the tumor to invade the surrounding brain tissue and the generation of a local inflammatory state between the tumor cells and parenchyma. While there is evidence to suggest that interleukin‑6 (IL‑6) induces craniopharyngioma (CP)‑associated inflammation, particularly in ACP, the role of IL‑6 in the progression of ACP remains unclear. The results of the present study demonstrated that CP inflammation was associated with pathological classification, extent of surgery, degree of calcification and postoperative hypothalamic status scale...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28486603/clinical-identification-of-oncogenic-drivers-and-copy-number-alterations-in-pituitary-tumors
#20
Wenya Linda Bi, Noah F Greenwald, Shakti H Ramkissoon, Malak Abedalthagafi, Shannon M Coy, Keith L Ligon, Yu Mei, Laura MacConaill, Matt Ducar, Le Min, Sandro Santagata, Ursula B Kaiser, Rameen Beroukhim, Edward R Laws, Ian F Dunn
Pituitary tumors are the second most common adult primary brain tumor, with a variable clinical course. Recent work has identified a number of genetic determinants of pituitary tumor subtypes, which may augment classic histopathologic classification schemes. We sought to determine whether pituitary tumors could be stratified based on objective molecular characteristics using a clinical genomics assay. We profiled pituitary tumors using OncoPanel, a clinical multiplexed next-generation sequencing assay and retrospectively collected the clinical information and sequencing results for 127 patients from 2012-2016 at the Brigham and Women's Hospital...
May 8, 2017: Endocrinology
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