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Craniopharyngioma

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https://www.readbyqxmd.com/read/28097839/nutritional-assessment-of-a-population-with-a-history-of-childhood-craniopharyngioma-seen-at-hospital-prof-dr-juan-p-garrahan
#1
Carolina Caminiti, Carola Saure, Ilanit Bomer, Mercedes Brea, Javier González Ramos
INTRODUCTION: Craniopharyngiomas are histologically benign malformations located between the pituitary and hypothalamus that may affect key hormone secretion for endocrine regulation and satiety modulation. Although this is a relatively benign disease, the combination of severe hypothalamic obesity and associated comorbidities results in a reduced quality of life. OBJECTIVE: To assess the nutritional status of patients after craniopharyngioma surgery. POPULATION AND METHODS: Patients younger than 21 years old at the time of the study who required craniopharyngioma surgery at Hospital de Pediatr...
1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28096982/the-birth-and-rise-of-a-craniopharyngioma-the-radiological-evolution-of-an-incidental-craniopharyngioma-detected-on-serial-mri-during-medical-treatment-of-a-macroprolactinoma
#2
Stefano Mariotti, Marco Losa, Pietro Mortini, Luca Saba
This case demonstrates the rare coexistence of a prolactinoma with craniopharyngioma and documents its radiological growth. This case suggests that patients with pituitary neoplasms should be followed closely and although prolactinomas can often be managed medically, a coexistent other lesion may require surgery for histological assessment and to reduce mass effect.
January 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28089805/surgical-outcomes-of-endoscopic-endonasal-skull-base-surgery-of-craniopharyngiomas-evaluated-according-to-the-degree-of-hypothalamic-extension
#3
Shigetoshi Yano, Takuichiro Hide, Naoki Shinojima
OBJECTIVE: Sparing the hypothalamus following craniopharyngiomas treatment is a prerequisite to ensure a good quality of life. In this study, the functional prognosis of craniopharyngioma following Endoscopic endonasal skull base surgery (EES) was examined in function of the degree of hypothalamic extension. MATERIALS AND METHODS: Twenty cases of craniopharyngioma treated by EES were categorized according to Puget's classification using preoperative and postoperative MRI...
January 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28084922/initial-experience-with-endoscopic-ultrasonic-aspirator-in-purely-neuroendoscopic-removal-of-intraventricular-tumors
#4
Giuseppe Cinalli, Alessia Imperato, Giuseppe Mirone, Giuliana Di Martino, Giancarlo Nicosia, Claudio Ruggiero, Ferdinando Aliberti, Pietro Spennato
OBJECTIVE Neuroendoscopic removal of intraventricular tumors is difficult and time consuming because of the lack of an effective decompression system that can be used through the working channel of the endoscope. The authors report on the utilization of an endoscopic ultrasonic aspirator in the resection of intraventricular tumors. METHODS Twelve pediatric patients (10 male, 2 female), ages 1-15 years old, underwent surgery via a purely endoscopic approach using a Gaab rigid endoscope and endoscopic ultrasonic aspirator...
January 13, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28084862/visual-outcome-endocrine-function-and-tumor-control-after-fractionated-stereotactic-radiation-therapy-of-craniopharyngiomas-in-adults-findings-in-a-prospective-cohort
#5
Arnar Astradsson, Per Munck Af Rosenschöld, Ulla Feldt-Rasmussen, Lars Poulsgaard, Anne Katrine Wiencke, Lars Ohlhues, Svend Aage Engelholm, Helle Broholm, Emil Hansen Møller, Marianne Klose, Henrik Roed, Marianne Juhler
BACKGROUND: The purpose of this study was to examine visual outcome, endocrine function and tumor control in a prospective cohort of craniopharyngioma patients, treated with fractionated stereotactic radiation therapy (FSRT). MATERIAL AND METHODS: Sixteen adult patients with craniopharyngiomas were eligible for analysis. They were treated with linear accelerator-based FSRT during 1999-2015. In all cases, diagnosis was confirmed by histological analysis. The prescription dose to the tumor was 54 Gy (median, range 48-54) in 1...
January 13, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28073908/the-neuroendocrine-sequelae-of-paediatric-craniopharyngioma-a-40-year-meta-data-analysis-of-185-cases-from-three-uk-centres
#6
Timothy Shao Ern Tan, Leena Patel, Jaya Sujatha Gopal-Kothandapani, Sarah Ehtisham, Esieza Clare Ikazoboh, Richard Hayward, Kristian Aquilina, Mars Skae, Nicky Thorp, Barry Pizer, Mohammed Didi, Conor Mallucci, Joanne C Blair, Mark N Gaze, Ian Kamaly-Asl, Helen Spoudeas, Peter E Clayton
Objectives The management of paediatric craniopharyngiomas was traditionally complete resection (CR), with better reported tumour control compared to partial resection (PR) or limited surgery (LS). The subsequent shift towards hypothalamic-sparing, conservative surgery with adjuvant radiotherapy (RT) to any residual tumour, aimed at reducing neuroendocrine morbidity, has not been systematically studied. Hence, we reviewed the sequelae of differing management strategies in paediatric craniopharyngioma across three UK tertiary centres over four decades...
January 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28069929/genomic-alterations-of-adamantinomatous-and-papillary-craniopharyngioma
#7
Tobias Goschzik, Marco Gessi, Verena Dreschmann, Ursel Gebhardt, Linghua Wang, Shigeru Yamaguchi, David A Wheeler, Libero Lauriola, Ching C Lau, Hermann L Müller, Torsten Pietsch
Craniopharyngiomas are rare histologically benign but clinically challenging neoplasms. To obtain further information on the molecular genetics and biology of craniopharyngiomas, we analyzed a cohort of 121 adamantinomatous and 16 papillary craniopharyngiomas (ACP, PCP). We extracted DNA from formalin-fixed paraffin-embedded tissue and determined mutational status of CTNNB1, BRAF, and DDX3X by Sanger sequencing, next generation panel sequencing, and pyrosequencing. Sixteen craniopharyngiomas were further analyzed by molecular inversion profiling (MIP); 76...
January 9, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28061501/malignant-transformation-of-craniopharyngioma-without-radiation-therapy-case-report-and-review-of-the-literature
#8
Tae Seok Jeong, Gi Taek Yee, Na Rae Kim
Craniopharyngiomas exhibiting histologic malignancy are extremely rare. Herein, we report the case of a 26-year-old male patient who underwent suprasellar mass excision via an interhemispheric transcallosal approach. Histopathological examination indicated that the craniopharyngioma was of the adamantinomatous subtype. The patient received postoperative medical treatment for endocrine dysfunction and diabetes mellitus without radiation treatment. Two years after the operation, he presented with progressive visual disturbance and altered mentality...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28059655/norman-m-dott-master-of-hypothalamic-craniopharyngioma-surgery-the-decisive-mentoring-of-harvey-cushing-and-percival-bailey-at-peter-bent-brigham-hospital
#9
Ruth Prieto, José M Pascual
Norman McOmish Dott (1897-1973) developed surgical neurology in Edinburgh, Scotland, and was a scholar of worldwide renown. One of Dott's most notable contributions to neurosurgery was his understanding of hypothalamic physiology, mostly acquired through the comprehensive study of patients with lesions involving this region of the diencephalon, particularly craniopharyngiomas (CPs). Recognition of symptoms caused by hypothalamic disturbances allowed him to predict the accurate anatomical relationships between CPs and the hypothalamus, despite the rudimentary radiological methods available during the 1930s...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28048024/su-f-t-116-predicting-iq-and-the-risk-of-hearing-loss-following-proton-versus-photon-radiotherapy-for-pediatric-brain-tumor-patients
#10
D Fortin, A Ng, D Tsang, M Sharpe, N Laperriere, D Hodgson
PURPOSE: The increased sparing of normal tissues in intensity modulated proton therapy (IMPT) compared to photon intensity modulated radiotherapy (IMRT) in brain tumor treatments should translate into improved neurocognitive outcomes. Models were used to estimate the intelligence quotient (IQ) and the risk of hearing loss 5 years post radiotherapy and to compare outcomes of proton against photon in pediatric brain tumors. METHODS: Patients who had received radical IMRT were randomly selected from our retrospective database: 10 cases each of craniopharyngioma, ependymoma and medulloblastoma, and 20 cases of glioma...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28017744/first-case-of-primary-sellar-suprasellar-intraventricular-ewing-sarcoma-case-report-and-review-of-literature
#11
Pier Paolo Mattogno, Davide Nasi, Corrado Iaccarino, Gabriele Oretti, Luisa Santoro, Antonio Romano
BACKGROUND: Intracranial Ewing Sarcoma (ES) and peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare and poorly differentiated neoplasms. Recent immunohistochemical and cytogenetic findings support the possibility of a unique nosological entity. Primary intracranial localization of this tumor is extremely rare: a small number of cases are reported in the literature, with only a part of them confirmed by genetic studies. CASE DESCRIPTION: We report the case of 12 year-old-patient affected by sellar-suprasellar mass with intraventricular extension that in all its features mimes a transinfundibular craniopharyngioma...
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28012064/patterns-of-care-and-treatment-outcomes-of-patients-with-craniopharyngioma-in-the-national-cancer-database
#12
Yuan J Rao, Comron Hassanzadeh, Benjamin Fischer-Valuck, Michael R Chicoine, Albert H Kim, Stephanie M Perkins, Jiayi Huang
To investigate the patterns of care and outcomes in patients with craniopharyngioma in the National Cancer Data Base (NCDB). This study included 697 patients (166 pediatric and 531 adult cases) treated for craniopharyngioma between 2004 and 2012 in the NCDB. Adjuvant radiotherapy (RT) was defined if within 6 months of surgery. Limited surgery (LS) was defined as biopsy or subtotal resection. Proportional-hazards models were used to evaluate associations between covariates and overall survival (OS). A time-dependent analysis of RT was performed to account for early deaths after surgery...
December 23, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28009237/letter-to-the-editor-recurrent-or-residual-craniopharyngioma-management-options
#13
Anirudh Srinivasan
No abstract text is available yet for this article.
December 23, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28008190/central-diabetes-insipidus
#14
REVIEW
Hiroshi Arima, Yoshinori Azuma, Yoshiaki Morishita, Daisuke Hagiwara
Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous study suggests that infundibulo-neurohypophysitis might be an underlying cause of idiopathic CDI. Among secondary CDI, the tumors in the central nervous system such as craniopharyngioma and germ cell tumors are the most frequent causes...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28005815/analysis-and-long-term-follow-up-of-the-surgical-treatment-of-children-with-craniopharyngioma
#15
Jing Cheng, Qiang Shao, Zhiyong Pan, Jin You
OBJECTIVE: To investigate the relationship between the operative approach, clinical pathological factors, and curative effect of the surgical treatment in the patients with craniopharyngioma; to provide a theoretical basis for determining the prognosis and reducing the recurrence rate during the long-term postoperative follow-up in children. METHODS: This was a retrospective analysis of the clinical data of 92 children who underwent surgical treatment in our department from May 2011 to January 2005...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27993737/bolstering-the-nasoseptal-flap-using-sphenoid-sinus-fat-packing-a-technical-case-report
#16
Hussam Abou-Al-Shaar, Hasan A Zaidi, David J Cote, Edward R Laws
BACKGROUND: Resection of extensive skull base lesions often necessitates relatively large dural openings and arachnoid, resulting in skull base defects with the potential for a post-operative cerebrospinal fluid (CSF) leak. A nasoseptal flap (NSF) is a vascularized graft which has greatly diminished the incidence of CSF leak. Annealing of flaps against the ventral skull base can be tenuous within the first few days after surgery. We report the use of sphenoid sinus fat packing as a buttress to support the nasoseptal flap during skull base reconstruction...
December 16, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27983534/osteoblastic-differentiation-and-cell-calcification-of-adamantinomatous-craniopharyngioma-induced-by-bone-morphogenetic-protein-2
#17
Xiaorong Yan, Dezhi Kang, Jun Pan, Changzhen Jiang, Yuanxiang Lin, Songtao Qi
BACKGROUND: The calcification of adamantinomatous craniopharyngioma (ACP) often creates difficulties for surgical therapy. Nevertheless, the mechanism of ACP calcification is unclear. Our previous studies demonstrated that osteoblastic factors might play important roles in ACP calcification. OBJECTIVE: We examined the effects of recombinant human Bmp2 on ACP cell differentiation by testing osteoblastic proteins and calcium deposition. METHODS: The expression of osteoblastic factors including osteopontin (OPN), Runx2, and osterix in Bmp2-treated ACP cells was examined by western blot and/or real time PCR...
December 9, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27981519/craniopharyngiomas-a-life-changing-tumor
#18
EDITORIAL
Pietro Mortini
No abstract text is available yet for this article.
December 16, 2016: Endocrine
https://www.readbyqxmd.com/read/27981514/visceral-adiposity-index-as-an-indicator-of-cardiometabolic-risk-in-patients-treated-for-craniopharyngioma
#19
Francesco Ferraù, Federica Spagnolo, Oana Ruxandra Cotta, Laura Cannavò, Angela Alibrandi, Giuseppina Tiziana Russo, Tommaso Aversa, Francesco Trimarchi, Salvatore Cannavò
PURPOSE: Craniopharyngioma is associated with metabolic alterations leading to increased cardiovascular mortality. Recently, the visceral adiposity index has been proposed as a marker of visceral adipose tissue dysfunction and of the related cardiometabolic risk. The role of the visceral adiposity index has never been explored in craniopharyngioma patients. We assessed the cardiometabolic risk on the basis of the visceral adiposity index in craniopharyngioma patients. METHODS: We evaluated data of 24 patients treated for craniopharyngioma in a single-centre...
December 16, 2016: Endocrine
https://www.readbyqxmd.com/read/27973392/cystic-craniopharyngiomas-microsurgical-or-stereotactic-treatment
#20
Walter Rachinger, Florian Oehlschlaegel, Mathias Kunz, Manuel Fuetsch, Christian Schichor, Stephan Thurau, Jochen Schopohl, Klaus Seelos, Jörg-Christian Tonn, Friedrich-Wilhelm Kreth
BACKGROUND: Prognosis and treatment of cystic craniopharyngiomas are poorly defined. OBJECTIVE: To analyze progression-free survival (PFS) and safety profile of cystic craniopharyngiomas undergoing resection or minimally invasive drainage procedures. We compared further outcome measurements for cystic and solid tumors undergoing resection to elucidate the impact of the initial tumor composition on both PFS and the toxicity profile. METHODS: All patients with craniopharyngiomas consecutively treated between 1999 and 2014 were included...
August 25, 2016: Neurosurgery
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