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Craniopharyngioma

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https://www.readbyqxmd.com/read/28781761/recent-advances-in-molecular-pathology-of-craniopharyngioma
#1
REVIEW
Sarah Larkin, Niki Karavitaki
Craniopharyngiomas are rare epithelial tumours arising along the path of the craniopharyngeal duct. Two major histological subtypes have been recognised, the papillary and the adamantinomatous. Craniopharyngiomas remain challenging tumours to manage and are associated with significant morbidities and mortality. Recent advances in the molecular pathology of these neoplasms have identified BRAF mutations in the papillary variant, offering promising options for targeted pharmacological treatment. The involvement of β-catenin and the Wnt pathway in the tumorigenesis of the adamantinomatous subtype has been previously established with the identification of stabilising mutations in exon 3 of CTNNB1...
2017: F1000Research
https://www.readbyqxmd.com/read/28774763/anatomic-dissection-of-arachnoid-membranes-encircling-the-pituitary-stalk-on-fresh-non-formalin-fixed-specimens-anatomo-radiologic-correlations-and-clinical-applications-in-craniopharyngioma-surgery
#2
P Ciappetta, L Pescatori
BACKGROUND: The anatomy of the arachnoid membranes and cisternal spaces around the pituitary stalk has not been yet exhaustively described and understood. In this study we performed a detailed anatomic study on fresh non formalin fixed cadavers of the arachnoid membranes encircling the pituitary stalk and correlate our anatomic findings with MRI. METHODS: Ten fresh, non formalin-fixed non silicon-injected adult cadaveric heads were analyzed in this study. The membrane and cisterns that have been studied for our study are: - The diaphragma sellae and its dural components; - The basal arachnoid membrane; - The Lilequist's membrane with its diencephalic and mesencephalic portion; - The medial carotid membrane; - The chiasmatic cistern; - The pituitary stalk...
July 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28766000/-pediatric-brain-tumors
#3
REVIEW
W Reith, S Bodea, R Mühl-Benninghaus
Brain tumors differ between children and adults both in histology and localization. Malignant gliomas and meningiomas predominate in adults while medulloblastomas and low-grade astrocytomas are the most frequent brain tumors in children. More than one half (50-70%) of pediatric brain tumors have an infratentorial location but only approximately 30% in adults. Brain tumors can be recognized in sonography, cranial computed tomography (CCT) and magnetic resonance imaging (MRI) by their space-consuming character and by their divergent density and intensity in comparison to normal brain parenchyma...
August 1, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28761533/outcome-following-surgical-resection-of-craniopharyngiomas-a-case-series
#4
K C Bidur, Devkota Upendra Prasad
INTRODUCTION: Debate continues as to the optimum treatment for craniopharyngioma; radical surgical resection or partial resection followed by radiotherapy. Radical surgical resection may be complicated by intraoperative injury to surrounding structures and stormy postoperative hormonal problem. This study aims to examine the result of safe maximal surgical resection. MATERIALS AND METHODS: Retrospective study of all histopathologically proven craniopharyngiomas who had undergone surgical resection over an almost 8 year period was included...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28761508/sphenoid-wing-en-plaque-meningioma-development-following-craniopharyngioma-surgery-and-radiotherapy-radiation-induced-after-three-decades
#5
REVIEW
Amol Raheja, Guru Dutta Satyarthee
Radiation therapy is widely used as adjuvant or primary treatment modality of neoplastic lesions. Radiation therapy may cause an acute adverse effect such as brain edema, radiation necrosis, or delayed, for example, panhypopituitarism, vasculitis, and rare de-novo neoplasm development. However, radiation-induced meningioma (RIM) occurrence is extremely rare. A detailed PubMed and Medline search yielded only three isolated Case-reports of RIM development in craniopharyngioma cases receiving radiotherapy after surgery...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28749844/effect-of-preserving-the-pituitary-stalk-during-resection-of-craniopharyngioma-in-children-on-the-diabetes-insipidus-and-relapse-rates-and-long-term-outcomes
#6
Jing Cheng, Yanqin Fan, Bo Cen
OBJECTIVE: The objective of this study was to investigate the effect of preserving an infiltrated pituitary stalk during the resection of craniopharyngioma of pituitary stalk origin on postoperative outcomes and thus provide a theoretical basis for microsurgical treatment and prognosis. METHODS: We screened the clinical data of all 103 pediatric patients with craniopharyngioma undergoing surgical treatment at our department between January 2006 and January 2013 and conducted a retrospective analysis of 82 patients with craniopharyngioma originating in the pituitary stalk...
July 26, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28732411/in-reply-to-craniopharyngioma-surgical-outcome-as-related-to-the-degree-of-hypothalamic-involvement
#7
Shigetoshi Yano, Takuichiro Hide, Naoki Shinojima
No abstract text is available yet for this article.
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28732410/craniopharyngioma-surgical-outcome-as-related-to-the-degree-of-hypothalamic-involvement
#8
Ruth Prieto, José María Pascual, Inés Castro-Dufourny, Rodrigo Carrasco, Laura Barrios
No abstract text is available yet for this article.
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28718234/paediatrics-brain-imaging-in-epilepsy-common-presenting-symptoms-and-spectrum-of-abnormalities-detected-on-mri
#9
Azmat Ali, Faiza Akram, Ghayyur Khan, Shaukat Hussain
BACKGROUND: Epilepsy, a common neurological disorder can present at any age and has a number of aetiologies with underlying brain disease being the most common aetiology. Brain imaging becomes important and mandatory in the work up for epilepsy in localization and lateralization of the seizure focus. METHODS: This cross-sectional study was conducted in the department of Radiology Ayub Medical Teaching Institution Abbottabad from 1st March 2015 to 31st March 2016...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28709442/can-recurrences-be-predicted-in-craniopharyngiomas-%C3%AE-catenin-coexisting-with-stem-cells-markers-and-p-atm-in-a-clinicopathologic-study-of-45cases
#10
Elia Guadagno, Oreste de Divitiis, Domenico Solari, Giorgio Borrelli, Umberto Marcello Bracale, Alberto Di Somma, Paolo Cappabianca, Marialaura Del Basso De Caro
BACKGROUND: Recurrence is a common feature of craniopharyngiomas, benign tumors that origin from squamous epithelial remnants of Rathke's pouch- arising at any segment of its whole course. There are two histotypes, showing different morphology and clinical behavior: adamantinomatous(adaCP) and papillary (papCP). An univocal strategy of management has not yet been defined, being considered the combination of surgery and radiotherapy the most effective, especially in case of incomplete resection...
July 14, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28707994/do-craniopharyngioma-molecular-signatures-correlate-with-clinical-characteristics
#11
Sacit Bulent Omay, Yu-Ning Chen, Joao Paulo Almeida, Armando Saul Ruiz-Treviño, John A Boockvar, Philip E Stieg, Jeffrey P Greenfield, Mark M Souweidane, Ashutosh Kacker, David J Pisapia, Vijay K Anand, Theodore H Schwartz
OBJECTIVE Exome sequencing studies have recently demonstrated that papillary craniopharyngiomas (PCPs) and adamantinomatous craniopharyngiomas (ACPs) have distinct genetic origins, each primarily driven by mutually exclusive alterations: either BRAF ( V600E), observed in 95% of PCPs, or CTNNB1, observed in 75%-96% of ACPs. How the presence of these molecular signatures, or their absence, correlates with clinical, radiographic, and outcome variables is unknown. METHODS The pathology records for patients who underwent surgery for craniopharyngiomas between May 2000 and March 2015 at Weill Cornell Medical College were reviewed...
July 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28702053/etiology-of-hypopituitarism-in-adult-patients-the-experience-of-a-single-center-database-in-the-serbian-population
#12
M Doknić, S Pekić, D Miljić, I Soldatović, V Popović, M Stojanović, M Petakov
There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. To present data regarding the etiology of hypopituitarism collected in a tertiary center over the last decade. This is a cross-sectional database study. Patients and Methods. We included 512 patients (pts) with hypopituitarism, with a mean age of 45.9 ± 1.7 yrs (range: 18-82; male: 57.9%). Results. Nonfunctional pituitary adenomas were presented in 205 pts (40...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28693060/-an-analysis-of-four-cases-of-misdiagnosed-primary-lymphocytic-hypophysitis
#13
Q Wei, L Zang, Y J Li, W J Gu, N Jin, Q H Guo, J Du, J M Ba, Z H Lyu, J M Lu, J T Dou, Y M Mu, G Q Yang
To improve the differential diagnosis of sellar region mass, 4 cases with sellar mass and misdiagnosed as lymphocytic hypophysitis (LYH) were reviewed retrospectively.The 4 patients (2 male and 2 female) aged 20-60 years old were all presented with symptoms of headache, polydipsia and polyuria.Biochemical studies confirmed the diagnoses of central diabetes insipidus and hypopituitarism.Head MRI scans showed LYH like image for all the cases, and, thus, high dose methylprednisolone pulse therapy (HDMPT) was applied to the patients...
July 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28676314/cerebrospinal-fluid-leaks-after-transsphenoidal-surgery-effect-of-a-polyethylene-glycol-hydrogel-dural-sealant
#14
REVIEW
Erlick A C Pereira, Carly A Grandidge, Victoria A Nowak, Simon A Cudlip
To investigate cerebrospinal fluid (CSF) leak rates after mainly endoscopic endonasal transsphenoidal surgery with and without polyethylene glycol hydrogel dural sealant (DuraSeal®), we prospectively collected data from a single-centre consecutive case series over four years from January 2007 to December 2010 inclusive. 250 patients were identified (135 male, 115 female; median age 52years, range 14-83). 180 patients received DuraSeal® (72%). 85 (34%) had intra-operative dural breach and 13 (5.2%) developed post-operative CSF leaks (3 without intra-operative dural breach) requiring lumbar drainage or formal repair...
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28670657/risk-factors-for-new-onset-shunt-dependency-after-craniotomies-for-intracranial-tumors-in-adult-patients
#15
Sayied Abdol Mohieb Hosainey, Benjamin Lassen, John K Hald, Eirik Helseth, Torstein R Meling
The risk of developing a de novo shunt-dependent hydrocephalus (HC) after undergoing a craniotomy for brain tumor in adult patients is largely unknown. All craniotomies for intracranial tumors at Oslo University Hospital in adult patients ≥18 years of age during a 10-year period (2004-2013) were included. None were lost to follow-up. Patients who developed a shunt-dependent HC were identified by cross-linking our prospectively collected tumor database to patients with a NCSP surgical procedure code of hydrocephalus (AAF)...
July 3, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28669298/letter-to-the-editor-surgical-strategy-for-craniopharyngiomas-and-the-tumor-infundibulum-relationship
#16
André Beer-Furlan, Ali O Jamshidi, Ricardo L Carrau, Daniel M Prevedello
No abstract text is available yet for this article.
July 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28667391/-tumors-of-the-sellar-region
#17
REVIEW
J M Lieb, F J Ahlhelm
METHODICAL ISSUE: The anatomy of the sellar region is complex and tumors of the sellar region are very variable because they arise from the many different tissue types in the sellar region, ranging from benign to life-threatening. Despite this variety, approximately 80% of sellar region tumors are due to the 5 most common lesions: adenomas, meningiomas, aneurysms, astrocytomas and craniopharyngiomas. STANDARD RADIOLOGICAL METHODS: In addition to clinical and laboratory results, the magnetic resonance imaging (MRI) and computed tomography (CT) results including the exact anatomical position and the proliferation pattern of the lesion are decisive for the diagnosis...
June 30, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28666908/volumetric-modulated-dynamic-wavearc-therapy-reduces-the-dose-to-the-hippocampus-in-patients-with-pituitary-adenomas-and-craniopharyngiomas
#18
Megumi Uto, Takashi Mizowaki, Kengo Ogura, Yuki Miyabe, Mitsuhiro Nakamura, Nobutaka Mukumoto, Hideaki Hirashima, Masahiro Hiraoka
PURPOSE: Reducing the radiation dose to the hippocampus is important to preserve cognitive function in patients with brain tumors. The Vero4DRT system can realize a new irradiation technique, termed volumetric-modulated Dynamic WaveArc therapy (VMDWAT), which allows the safe use of sequential noncoplanar volumetric-modulated beams without couch rotation. Because VMDWAT appears to reduce the hippocampal dose in patients with pituitary adenomas and craniopharyngiomas, we performed a planning study to compare the dose distribution of volumetric-modulated arc therapy using only a coplanar arc (coVMAT) and VMDWAT...
April 13, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28665393/-radiotherapy-and-radiosurgery-in-treatment-of-craniopharyngiomas
#19
A N Savateev, Yu Yu Trunin, N A Mazerkina
Craniopharyngiomas are benign epithelial tumors having a dysembryogenetic origin, which are usually located in the sellar/parasellar and/or third ventricle regions. Gross total resection is the modern standard of treatment for these tumors because of a low recurrence rate. However, this surgery in some patients with craniopharyngioma often leads to the development or worsening of diencephalic disorders poorly responding to treatment. Perhaps, in these cases, subtotal or partial tumor resection or implantation of an Ommaya reservoir into the tumor cyst followed by stereotactic radiotherapy/radiosurgery may provide better functional outcomes and higher life quality in patients, with tumor growth control being reasonable (according to the published data, the mean 10-year disease-free survival is 66...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28661562/predictors-of-visual-outcome-in-patients-operated-for-craniopharyngioma-a-danish-national-study
#20
Mads Forslund Jacobsen, Ann Sofia Skou Thomsen, Daniella Bach-Holm, Ghazaleh Doroudian, Kamilla Rothe Nissen, Kåre Fugleholm, Lars Poulsgaard, Volkert Siersma, Steffen Heegaard
PURPOSE: Craniopharyngioma often causes visual loss due to the close relation to the anterior visual pathways. This study investigates the incidence and predictors of visual outcomes in patients with craniopharyngioma. METHODS: Data from sixty-six patients who underwent surgery for craniopharyngioma from 2009 to 2013 in Denmark were reviewed. Primary outcomes were visual acuity (VA) and visual field (VF) defects from pre-and postoperative visits. Secondary outcomes were optic nerve atrophy (OA) and papilledema...
June 29, 2017: Acta Ophthalmologica
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