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Sunil Manjila, Nadine El Asmar, Benjamin M Vidalis, Fernando Alonso, Gagandeep Singh, Karthik Vadamalai, Mark L Cohen, Nicholas C Bambakidis, Baha M Arafah, Warren R Selman
BACKGROUND: The authors present cystic epithelial masses in the suprasellar region which on histopathology revealed 4 mixed tumors having simple cuboidal epithelium of Rathke's Cleft Cyst (RCC) elements trapped within pituitary adenoma, epidermoid cyst, dermoid cyst, and papillary craniopharyngioma respectively. OBJECTIVE: To highlight the developmental theory of ectodermal continuum in the realm of suprasellar epithelial cystic lesions and examines the cardinal aspects that distinguish RCC from its confounder, ciliary craniopharyngioma...
July 12, 2018: Neurosurgery
Huy Q Truong, Edinson Najera, Robert Zanabria-Ortiz, Emrah Celtikci, Xicai Sun, Hamid Borghei-Razavi, Paul A Gardner, Juan C Fernandez-Miranda
OBJECTIVE The endoscopic endonasal approach has become a routine corridor to the suprasellar region. The superior hypophyseal arteries (SHAs) are intimately related to lesions in the suprasellar space, such as craniopharyngiomas and meningiomas. Here the authors investigate the surgical anatomy and variations of the SHA from the endoscopic endonasal perspective. METHODS Thirty anatomical specimens with vascular injection were used for endoscopic endonasal dissection. The number of SHAs and their origin, course, branching, anastomoses, and areas of supply were collected and analyzed...
July 13, 2018: Journal of Neurosurgery
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Medicine (Baltimore)
Yun-Sik Dho, Yong Hwy Kim, Jin Wook Kim, Chul-Kee Park, Hyun-Tai Chung, Seung-Ki Kim, Sun Ha Paek, Kyu-Chang Wang, Dong Gyu Kim
OBJECT: To analyze the outcomes of gamma knife radiosurgery (GKS) for craniopharyngiomas and elucidate the optimal strategy. METHODS: Between 1998 and 2016, 35 patients underwent GKS for the treatment of 40 recurrent or residual craniopharyngiomas. Among 40 GKSs, 22 procedures were single-session GKSs and 18 procedures were fractionated GKSs. In cases of single-session GKS, the median marginal dose was 15 Gy (range 10-20 Gy). In cases of fractionated GKS, the median marginal dose was 6 Gy (range 5-7...
July 9, 2018: Journal of Neuro-oncology
Maryam Babaei, Ruhollah Ghahramani-Asl, Hamid-Reza Sadoughi, Dariush Sardari, Sohrab Shahzadi
Over 90% of craniopharyngeal brain tumors are cystic, which enables the injection of beta emitters such as phosphorus-32 (32 P) radio-colloid into cysts for their treatment. The aim of this study was to evaluate the clinical and theoretical modelling of Bremsstrahlung radiation dose resulting from stereotactic radio-colloid therapy of cystic craniopharyngioma tumors with 32 P. 32 P radio-colloid with appropriate activity concentration was injected to a head phantom, and then the Bremsstrahlung radiation spectrum and planar images were obtained using a gamma camera...
July 9, 2018: Australasian Physical & Engineering Sciences in Medicine
Bin Tang, Shen Hao Xie, Li Min Xiao, Guan Lin Huang, Zhi Gang Wang, Le Yang, Xuan Yong Yang, Shan Xu, Ye Yuan Chen, Yu Qiang Ji, Er Ming Zeng, Tao Hong
Endoscopic endonasal approach for craniopharyngioma (CP) resection provides a wide view and direct observation of hypothalamus and origin of tumor. Under endoscopy, 92 CPs were classified into 2 types: Peripheral and Central, according to its relation to pituitary stalk. Peripheral type was further divided into 3 subtypes: Hypothalamic stalk, Suprasellar stalk and Intrasellar stalk CP, according to the different origin site along hypothalamus-pituitary axis. Peripheral type arisen from the stalk but expanded and grown laterally in an exophytic pattern, accounting for 71...
July 5, 2018: Scientific Reports
Amar Agha, Lucy Ann Behan, Hannah Forde, Kathy Maher, Norman F Taylor, Diarmuid Smith, Christopher J Thompson, William M Drake, John P Monson
Purpose Pituitary patients with different aetiologies of hypopituitarism exhibit differing phenotypes despite similar replacement therapy strategies. We hypothesised that differential regulation of the isoenzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD 1), which mediates the net autocrine conversion of cortisone to cortisol in adipose tissues and liver may play a role. Methods We studied 11β-HSD 1 activity (using urine cortisol/cortisone metabolites ratio), in 36 hypopituitary patients with treated craniopharyngiomas, treated remitted Cushing's disease and treated non-functioning pituitary adenomas+prolactinomas on and off GH (growth hormone) replacement...
July 5, 2018: Endocrine Practice
Aylin Mehren, Jale Özyurt, Paula Zu Klampen, Svenja Boekhoff, Christiane M Thiel, Hermann L Müller
INTRODUCTION: The current study aimed to assess whether childhood-onset craniopharyngioma patients suffer from symptoms of apathy, as assessed by patients themselves and their close others. We further analyzed whether apathy scores are related to symptoms of depression. METHODS: Childhood-onset craniopharyngioma patients (n = 35, 16 female, median age = 22) and matched healthy controls (n = 35, 19 female, median age = 21) were asked to complete self-ratings of the Apathy Evaluation Scale, whereas informant-ratings were obtained from their close others...
July 3, 2018: Journal of Neuro-oncology
Weijun Gu, Weizhong Gu, Yulin Gu, Jie Li, Guoqing Yang, Qinghua Guo, Li Zang, Jin Du, Yu Pei, Jianming Ba, Zhaohui Lv, Jingtao Dou, Yiming Mu
Craniopharyngiomas and germinomas are both rare cranial tumors that most commonly present during childhood or adolescence. Although these tumors have different origins, their clinical and radiological features may be similar. In this article, we report the case of a 35-year female patient with clinical and radiological findings and increased human chorionic gonadotrophin (HCG) levels in the cerebrospinal fluid (CSF) that were consistent with a germinoma. However, pathological analysis revealed a craniopharyngioma...
2018: Frontiers in Neurology
Patrícia Débora Cavalcanti Tosta-Hernandez, Adriana Aparecida Siviero-Miachon, Nasjla Saba da Silva, Andrea Cappellano, Marcelo de Medeiros Pinheiro, Angela Maria Spinola-Castro
Craniopharyngioma is a sellar/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis and post-treatment, total body fat, visceral adipose tissue, and metabolic syndrome components) and analyzed through multiple regression and logistic models...
June 29, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Jaclyn J Renfrow, Garret P Greeneway, Lacey Carter, Daniel E Couture
Craniopharyngiomas frequently recur locally or less commonly along the path of prior resection. Ectopic recurrence is rare, although cases are reported along the neuraxis spanning from the subgaleal space down to the S1 nerve root. This case reports on a girl with a history of craniopharyngioma first resected at 23 months of age with two local suprasellar recurrences managed with repeat craniotomy and external beam radiation therapy. At age 14 she complained of worsening headaches and brain MRI demonstrated an enhancing 1...
June 29, 2018: Journal of Neurosurgery. Pediatrics
Chenhao Hu, Jinhui Chen, Yuhong Meng, Jianning Zhang, Yaming Wang, Rui Liu, Xin Yu
To investigate the relationship of the expression of vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor-2 (VEGFR-2) and imaging features with the therapeutic efficacy of Phosphorus-32 colloid interstitial radiotherapy in recurrent craniopharyngioma.Thirty-two patients with recurrent craniopharyngioma underwent phosphorus-32 colloid interstitial radiotherapy. The tumor imaging features were classified into 4 types according to the thickness of the cyst wall and signals of the cyst contents as shown by computed tomography (CT) and magnetic resonance imaging (MRI) images...
June 2018: Medicine (Baltimore)
Elżbieta Andrysiak-Mamos, Karol Sagan, Leszek Sagan, Elżbieta Sowińska-Przepiera, Anhelli Syrenicz
The differentiation of cystic lesions located in the sellar-suprasellar region is a significant problem in clinical practice because of the similarities in their clinical, radiological, and even histopathological picture. Arriving at the right diagnosis is vital for taking appropriate therapeutic decisions. The most frequent clinical manifestation of lesions located in the sellar-suprasellar region is headache. It often co-exists with symptoms of anterior pituitary gland insufficiency or hyperprolactinaemia caused by compression of the pituitary stalk...
2018: Endokrynologia Polska
Weimin Ni, Xiang'en Shi
OBJECTIVE: Craniopharyngiomas (CPs) and their treatment are associated with hypothalamic damage that causes hypothalamic obesity (HO) in 30-70% of cases. Thus, there is ongoing research regarding tangible solutions for HO, as these patients have unrelenting resistance to basic weight-loss interventions. This review aims to summarize the interventions that are currently used to treat CP-related HO (CP-HO), including pharmacotherapy and bariatric surgery. METHODS: The Cochrane Library, EMBASE, and PubMed databases were searched up to June 2017 for relevant reports...
June 23, 2018: World Neurosurgery
Susan M Webb
No abstract text is available yet for this article.
June 22, 2018: Endocrine
Shunsunke Nomura, Yasuo Aihara, Kosaku Amano, Seiichiro Eguchi, Kentaro Chiba, Takashi Komori, Takakazu Kawamata
Malignant craniopharyngioma or anaplastic craniopharyngioma was first reported in 1987 by Akachi. It has a malignant clinical and histological feature; remarkably rapid progression, atypical pathology like squamous cell carcinoma and poor prognosis. To date seventeen cases of malignant craniopharyngioma have been reported and of these cases, most were of secondary malignant tumor in nature. With respect to traditional benign craniopharyngioma, adjunctive treatment after gross total removal is not necessary, but in the case of malignant types of the tumor, adjunctive treatment is important...
June 19, 2018: World Neurosurgery
Rachel K Peterson, Jason M Ashford, Sarah M Scott, Fang Wang, Hui Zhang, Julie A Bradley, Thomas E Merchant, Heather M Conklin
BACKGROUND: Childhood brain tumor diagnoses are stressful for families. Children diagnosed with craniopharyngioma (Cp) present with particularly challenging medical and cognitive problems due to tumor location and associated biophysiologic comorbidities. This study examined parental distress in a sample of families of patients with Cp treated with proton beam therapy to identify factors for targeting psychological intervention. PROCEDURE: Prior to (n = 96) and 1 year after (n = 73) proton therapy, parents of children diagnosed with Cp (9...
June 22, 2018: Pediatric Blood & Cancer
A N Shkarubo, K V Koval', B A Kadashev, D N Andreev, I V Chernov
Until recently, tumors of the clival region and ventral posterior cranial fossa were considered hard-to-reach and often inoperable via standard transcranial approaches. The introduction of minimally invasive methods combined with the endoscopic technique into neurosurgical practice has enabled removal of hard-to-reach tumors, including midline tumors of the ventral posterior cranial fossa. OBJECTIVE: To improve and introduce the extended endoscopic endonasal posterior (transclival) approach into clinical practice and to analyze the results of its application in surgical treatment of midline skull base tumors extending into the ventral posterior cranial fossa...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
X Y Lu, X J Fu, H H Zeng, Y Yao, L Wang
Objective: To research the application of lateral supraorbital (LOS) approach for resecting sellar tumors. Methods: Clinical symptoms of 20 patients with surgery via LOS approach were analyzed retrospectively.According to the neuroradiological findings and the improvement of symptoms, and some score scale, the efficacy and safety of LOS were assessed for removing sellar tumors.There were tuberculum sellae meningioma ( n =11), craniopharyngioma ( n =4), epidermoid cysts ( n =4) and pituitary adenoma ( n =1)...
June 19, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Thomas J Willson, Nicholas R Rowan, Eric W Wang
BACKGROUND: Inadvertent lateralization of the middle turbinate (MT) after endoscopic sinus surgery (ESS) is cited as a common complication that results in both outflow tract obstruction and recurrent symptoms. In endoscopic endonasal skull-base surgery, the MT is frequently lateralized during the parasagittal approach. Little is known about whether this strategy has unintended consequences on the adjacent paranasal sinuses. Intentional lateralization vs surgical resection of the MT were compared for radiographic evidence of sinus obstruction in this patient population...
June 19, 2018: International Forum of Allergy & Rhinology
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