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Craniopharyngioma

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https://www.readbyqxmd.com/read/28318194/-craniopharyngioma-and-klinefelter-syndrome-during-the-pubertal-transition-a-diagnostic-challenge
#1
Yamile Mocarbel, Graciela Arébalo de Cross, Marie C Lebrethon, Albert Thiry, Albert Beckersd, Hernan Valdes-Socin
Craniopharyngioma is the most common pituitary tumor in childhood. It can compromise the pubertal development because of its evolution or treatment. Syndrome of Klinefelter is the most common cause of hipergonadotrophic hypogonadism in males. The concomitant presentation of both entities is extremely low (1/109) and the pathophysiological association is questionned. We present the case of a 18-year-old Belgian patient. He had a diagnosis of craniopharyngioma in childhood and he presented with panhypopituitarism after radiotherapy and surgical treatment...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28295484/who-2016-classification-changes-and-advancements-in-the-diagnosis-of-miscellaneous-primary-cns-tumours
#2
Felix Sahm, David E Reuss, Caterina Giannini
This short review highlights significant changes and recent findings incorporated to varying extent in the WHO 2016 definition of a variety of tumours, including peripheral nerve sheath tumours, meningiomas, mesenchymal non-meningothelial tumours, melanocytic tumours, lymphomas and histiocytic tumours, germ cell tumours and non-neuroendocrine pituitary tumours. Most notable classification changes include: adding "hybrid nerve sheath tumours" to the spectrum of benign nerve sheath tumours; an updated definition of atypical meningioma (WHO grade II), including cases with brain invasion; recognizing dural solitary fibrous tumour (SFT) and haemangiopericytoma (HPC) as a single tumour entity characterized by NAB2 and STAT6 gene fusions for which the term solitary SFT/HPC was chosen; recognizing that pituitary granular cell tumour, spindle cell oncocytoma, and pituicytoma all share nuclear expression of TTF-1, possibly representing a spectrum of a single nosological entity derived from posterior pituitary glial cells...
March 12, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28286725/remarkable-diagnostic-magnetic-resonance-imaging-findings-in-sellar-xanthogranuloma-report-of-three-first-cases-in-latin-america
#3
Mario Tapia Céspedes, Jaime Pinto Vargas, Fernando Andrade Yañez, Loreto Spencer León, Pablo Álvarez Arancibia, Thomas Schmidt Putz
The sellar xanthogranuloma is a rare lesion of the sellar-parasellar region difficult to differentiate from other tumors such as craniopharyngiomas or Rathke's cleft cyst in the preoperative evaluation. As they are recently recognized as a separate entity and the few number of reports in the literature, its etiology is unknown and its impact remains uncertain. This article will describe the first three cases reported in Latin America, identified in one of them an imaging feature that may be helpful to elucidate an imaging growth pattern...
January 2017: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/28276095/a-case-of-symptomatic-granular-cell-tumor-of-the-sellar-region-with-large-calcification
#4
Shun Yamamuro, Taku Homma, Yuya Hanashima, Sodai Yoshimura, Hideki Oshima, Sumie Ohni, Yoshiaki Kusumi, Atsuo Yoshino
We report here a rare case of symptomatic granular cell tumor (GCT) of the sellar region with a large calcification. A 70-year-old woman presented with a sellar mass, accompanied by bitemporal hemianopia. The patient was diagnosed preoperatively as having a craniopharyngioma or a pituitary adenoma, because of the large calcification. The patient underwent surgical tumor resection via endoscopic trans-sphenoidal surgery and was diagnosed pathologically as having GCT. The patient's postoperative course was uneventful and her visual field disturbance improved soon after the operation...
March 9, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28263230/the-role-of-definitive-radiotherapy-in-craniopharyngioma-a-seer-analysis
#5
Chi Zhang, Vivek Verma, Elizabeth R Lyden, David P Horowitz, Brad E Zacharia, Chi Lin, Eileen P Connolly
OBJECTIVE: Assess patterns of care in the management of craniopharyngioma, especially with respect to the use of radiation therapy (RT) alone (which has been understudied to date) as compared with gross total resection (GTR) and subtotal resection (STR) with adjuvant RT. MATERIALS AND METHODS: The epidemiology, treatment modalities, and outcomes of patients with craniopharyngioma were studied using the Surveillance Epidemiology and End Results (SEER) database from 2004 to 2012...
March 3, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28261955/a-randomized-placebo-controlled-trial-of-beloranib-for-the-treatment-of-hypothalamic-injury-associated-obesity
#6
Ashley Shoemaker, Joseph Proietto, M Jennifer Abuzzahab, Tania Markovic, Jaret Malloy, Dennis D Kim
AIMS: Hypothalamic injury-associated obesity (HIAO) results from damage to the hypothalamus that often occurs with surgical removal/radiation therapy of tumors in the hypothalamic region, such as craniopharyngioma. There is currently no rigorously studied pharmaceutical treatment for the intractable weight gain and cardiometabolic consequences that occur in patients with HIAO. We aimed to assess efficacy, safety, and tolerability of beloranib treatment for 4 to 8 weeks in patients with HIAO...
March 6, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28260180/sleeve-gastrectomy-leads-to-easy-management-of-hormone-replacement-therapy-and-good-weight-loss-in-patients-treated-for-craniopharyngioma
#7
Manuela Trotta, Joël Da Broi, Angelo Salerno, Rosa M Testa, Giuseppe M Marinari
The aim of this study is to investigate the effects of sleeve gastrectomy on hormone replacement therapy and on hypothalamic obesity in patients affected by craniopharyngioma with post-surgical pan-hypopituitarism. A retrospective review of three patients, treated for hypothalamic obesity with laparoscopic sleeve gastrectomy, who have previously undergone surgery for craniopharyngioma in their childhood, was done. Patients' mean age and BMI were 22.3 years (range 21-24) and 49.2 kg/m(2) (range 41.6-58.1), respectively...
March 4, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28259055/hypothalamic-tumors-impact-gray-and-white-matter-volumes-in-fronto-limbic-brain-areas
#8
Jale Özyurt, Hermann L Müller, Monika Warmuth-Metz, Christiane M Thiel
Patients with hypothalamic involvement of a sellar/parasellar tumor often suffer from cognitive and social-emotional deficits that a lesion in the hypothalamus cannot fully explain. It is conceivable that these deficits are partly due to distal changes in hypothalamic networks, evolving secondary to a focal lesion. Focusing on childhood-onset craniopharyngioma patients, we aimed at investigating the impact of hypothalamic lesions on gray and white matter areas densely connected to the hypothalamus, and to relate structural changes to neuropsychological deficits frequently observed in patients...
February 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28254603/outcome-of-radical-surgical-resection-for-craniopharyngioma-with-hypothalamic-preservation-a-single-center-retrospective-study-of-1054-patients
#9
Xiang'en Shi, Zhongqing Zhou, Bin Wu, Yongli Zhang, Hai Qian, Yuming Sun, Yang Yang, Zaitao Yu, Zhiwei Tang, Shuaibin Lu
OBJECTIVE: A retrospective review of the surgical outcome for patients with craniopharyngioma (CP) treated in a single neurosurgical center with surgical resection using visualization to ensure hypothalamic preservation. METHODS: The study included 1054 patients. Prior to 2003, a pterional cranial approach was preferred for 78% of patients; after 2004, the unifrontal basal interhemispheric approach (UBIA) was performed in 79.1% of patients. RESULTS: Complete tumor resection was achieved in 89...
February 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28236350/review-of-xanthomatous-lesions-of-the-sella
#10
B K Kleinschmidt-DeMasters, Kevin O Lillehei, Todd C Hankinson
Xanthomatous lesions of the sellar region have traditionally been divided into two separate categories, xanthomatous hypophysitis (XH) and xanthogranuloma (XG) of the sellar region. The seminal paper on XH, a condition typified by foamy histiocytes and lymphoplasmacytic infiltrates in the pituitary gland/sellar region, but usually little or no hemosiderin pigment, detailed 3 patients. However, most reports since that time have been single cases, making understanding of the entity difficult. In contrast, the seminal report on XG, characterized by sellar region cholesterol clefts, lymphoplasmacytic infiltrates, marked hemosiderin deposits, fibrosis, multinucleated giant cells around cholesterol clefts, eosinophilic granular necrotic debris, and accumulation of macrophages, included 37 patients, allowing more insights into etiology...
February 25, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28236347/mini-symposium-adamantinomatous-craniopharyngioma-and-xanthomatous-lesions-of-the-sella
#11
Todd C Hankinson, B K Kleinschmidt-DeMasters
No abstract text is available yet for this article.
February 25, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28236180/supraorbital-subfrontal-trans-laminar-endoscope-assisted-approach-for-tumors-of-the-posterior-third-ventricle
#12
Maurizio Iacoangeli, Roberto Colasanti, Domenic Esposito, Alessandro Di Rienzo, Lucia di Somma, Mauro Dobran, Maurizio Gladi, Massimo Scerrati
BACKGROUND: Different surgical approaches have been developed for dealing with third ventricle lesions, all aimed at obtaining a safe removal minimizing brain manipulation. The supraorbital subfrontal trans-lamina terminalis route, commonly employed only for the anterior third ventricle, could represent, in selected cases with endoscopic assistance, an alternative approach to posterior third ventricular lesions. METHODS: Seven patients underwent a supraorbital subfrontal trans-laminar endoscope-assisted approach to posterior third ventricle tumors (two craniopharyngiomas, one papillary tumor of the pineal region, one pineocytoma, two neurocytomas, one glioblastoma)...
February 24, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28226329/transfrontal-and-transsphenoidal-approaches-to-pediatric-craniopharyngioma-a-national-perspective
#13
Yimo Lin, Daniel Hansen, Christina M Sayama, I-Wen Pan, Sandi Lam
INTRODUCTION: This study compared transsphenoidal (TS) and transfrontal (TF) approaches to craniopharyngioma utilizing a national database. METHODS: The Kids' Inpatient Database (2003, 2006, and 2009) was surveyed for patients with a diagnosis of craniopharyngioma who underwent a subset of surgical interventions to compare TS and TF surgery. Demographics, hospital variables, and complications/comorbidities were analyzed with multivariate regression. RESULTS: 314 admissions (TS = 104, TF = 210) were identified...
February 23, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28225310/central-diabetes-insipidus-clinical-characteristics-and-long-term-course-in-a-large-cohort-of-adults
#14
Hiba Masri-Iraqi, Dania Hirsch, Dana Herzberg, Avner Lifshitz, Gloria Tsvetov, Carlos Benbassat, Ilan Shimon
Purpose Central diabetes insipidus (CDI) is a rare heterogeneous condition with various underlying causes. This study sought to increase the still-limited data on the clinical characteristics and long-term course in adults diagnosed with CDI. Methods Data on demographics, presentation, imaging findings, affected pituitary axes, treatment, and complications were collected retrospectively from the files of 70 adult patients with CDI followed at a referral endocrine clinic. Results 40 women and 30 men were included...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28213803/first-experiences-with-neuropsychological-effects-of-oxytocin-administration-in-childhood-onset-craniopharyngioma
#15
Anika Hoffmann, Jale Özyurt, Kristin Lohle, Julia Reichel, Christiane M Thiel, Hermann L Müller
PURPOSE: The hypothalamic hormone oxytocin plays a major role in regulation of behavior and body composition. Quality of survival is frequently impaired in childhood craniopharyngioma patients due to sequelae such as behavioral deficits and severe obesity caused by tumor or treatment-related hypothalamic lesions. METHODS: In our pilot cross-sectional study, we analyzed emotion recognition abilities and oxytocin concentrations in saliva and urine before and after single nasal administration of 24 IU oxytocin in 10 craniopharyngioma patients...
February 17, 2017: Endocrine
https://www.readbyqxmd.com/read/28189861/vasospasm-after-craniopharyngioma-surgery-can-we-prevent-it
#16
Apinderpreeet Singh, Pravin Salunke, Vasundhara Rangan, Chirag K Ahuja, Sanjay Bhadada
BACKGROUND: Vasospasm following craniopharyngioma surgery, though rare, has been reported. Hypotheses regarding possible causative factors including major vessel handling during surgery and tumour cyst fluid spillage do not explain vasospasm occurring in the late post operative period. We have attempted to look into the probable pathogenic mechanisms of this complication and measures to prevent it. MATERIALS AND METHOD: Of 60 patients operated for Craniopharyngiomas over a period of 4 years, 6 who had clinical and radiologically demonstrable vasospasm were identified...
February 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28181780/diagnosis-treatment-clinical-course-and-prognosis-of-childhood-onset-craniopharyngioma-patients
#17
Hermann L Müller
CONTEXT: For decades gross-total resection was the preferred treatment option in childhood-onset craniopharyngioma, assuming that radical strategies at the time of initial diagnosis and treatment would result in cure. Recent reports on long-term prognosis, novel treatment approaches, and molecular genetics provide new insights into more risk-adapted treatment strategies in order to prevent sequelae such as hypothalamic syndrome. EVIDENCE ACQUISITION: A search for original articles published between 2000 and 2016 was performed in PubMed, Science Citation Index Expanded, EMBASE and Scopus...
February 9, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28180935/clinicopathological-features-and-microsurgical-outcomes-for-giant-pediatric-intracranial-tumor-in-60-consecutive-cases
#18
Ailing Guo, Vigneyshwar Suresh, Xianzhi Liu, Fuyou Guo
PURPOSE: Giant pediatric intracranial tumor (GPIT) remains to be a challenging disease with high morbidity and mortality. METHODS: The clinical data of 60 patients under 18 years of age operated on with GPIT (≥5 cm in diameter) were retrospectively analyzed. RESULTS: Gross total resection was achieved in 46 cases (77%) and subtotal resection was obtained in 14 cases (23%). Ninety percent (47/52) of the cases with obstructive hydrocephalus were resolved remarkably and only 10% (5/52) of the patients needed a ventriculoperitoneal shunt after tumor resection...
February 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28160775/craniopharyngioma-presenting-with-severe-hyponatremia-hyponatremia-induced-myopathy-and-panhypopituitarism-a-case-report
#19
M D S A Dilrukshi, G V N Sandakumari, P K Abeysundara, T Chang
BACKGROUND: Craniopharyngiomas are rare intracranial tumors commonly presenting with neurological symptoms. Reports of severe hyponatremia as a presenting manifestation of a craniopharyngioma and hyponatremia-induced myopathy are rare. We report the case of a patient with craniopharyngioma presenting with severe hyponatremia, panhypopituitarism, and hyponatremia-induced myopathy. CASE PRESENTATION: A 52-year-old Sri Lankan man presented with anorexia, nausea, fatigue, generalized muscle weakness, and cramps for 1 week...
February 5, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28155902/new-outlook-on-the-diagnosis-treatment-and-follow-up-of-childhood-onset-craniopharyngioma
#20
REVIEW
Hermann L Müller, Thomas E Merchant, Stephanie Puget, Juan-Pedro Martinez-Barbera
Childhood-onset craniopharyngiomas are rare embryonic tumours of low-grade histological malignancy. Novel insights into the molecular pathogenesis of human adamantinomatous craniopharyngioma have started to unveil the possibility of testing novel treatments targeting pathogenic pathways. Hypothalamic involvement and/or treatment-related lesions result in impaired physical and social functionality and in severe neuroendocrine sequelae. Quality of survival in patients with craniopharyngioma with hypothalamic involvement is impaired by severe obesity, physical fatigue and non-optimal psychosocial development...
February 3, 2017: Nature Reviews. Endocrinology
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