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https://www.readbyqxmd.com/read/29050310/microrna-27b-inhibition-promotes-nrf2-are-pathway-activation-and-alleviates-intracerebral-hemorrhage-induced-brain-injury
#1
Wenzhe Xu, Feng Li, Zhiguo Liu, Zhenkuan Xu, Bin Sun, Jingwei Cao, Yuguang Liu
Oxidative stress and neuroinflammation are the key factors leading to secondary brain injury after intracerebral hemorrhage (ICH). We investigated the effects of miR-27b, an oxidative stress-responsive microRNA, on ICH-induced brain injury in rats. The ICH model was induced by intracerebral injection of collagenase. Following ICH, miR-27b expression in the striatum was reduced, whereas expression of Nrf2 mRNA and protein was increased. In PC12 cells, overexpression of miR-27b reduced expression of Nrf2, Hmox1, Sod1 and Nqo1, while miR-27b inhibition had the opposite effects...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049338/growing-plants-on-oily-nutrient-poor-soil-using-a-native-symbiotic-fungus
#2
Timothy S Repas, D Michael Gillis, Zakia Boubakir, Xiaohui Bao, Gary J Samuels, Susan G W Kaminskyj
The roots of land plants associate with microbes, including fungal symbionts that can confer abiotic stress tolerance. Bitumen extraction following oil-sand surface mining in the Athabasca region of Alberta, Canada removes plant nutrients but leaves a petrochemical residue, making the coarse tailings (CT) hostile to both plants and microbes. We isolated an endophyte strain of the Ascomycete Trichoderma harzianum we call TSTh20-1 (hereafter, TSTh) from a dandelion that was naturally growing on CT. TSTh colonization allowed tomato, wheat, and remediation seed mixtures to germinate and their seedlings to flourish on CT without the use of fertilizer...
2017: PloS One
https://www.readbyqxmd.com/read/29048783/-investigation-on-silymarin-impact-on-lipopolysaccharide-induced-inflammation-model-based-on-arachidonic-acid-metabolism-pathway
#3
Danti Mai, Chan Yang, Yun Xue, Yan Wang, Chao Yan
The objective of this research is to investigate the suppressive effect of silymarin on vitro cell culture model of inflammatory macrophage RAW264.7 induced by Kdo2-Lipid A, and explore its mechanism based on cell metabonomics. Ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method was used in the cell metabonomic assay to quantitative analysis of metabolites related to eicosanoids pathway. Then chemometric approaches such as principal component analysis were used to process the metabolic data...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048427/hdac6-inhibition-by-tubastatin-a-is-protective-against-oxidative-stress-in-a-photoreceptor-cell-line-and-restores-visual-function-in-a-zebrafish-model-of-inherited-blindness
#4
Janina Leyk, Conor Daly, Ulrike Janssen-Bienhold, Breandán N Kennedy, Christiane Richter-Landsberg
Retinal diseases, such as hereditary retinitis pigmentosa and age-related macular degeneration, are characterized by the progressive loss of photoreceptors. Histone deacetylase 6 (HDAC6) is considered as a stress surveillance factor and a potential target for neuroprotection and regeneration. Overexpression of HDAC6 has been connected to neurodegenerative disorders, and its suppression may provide protection. Here we show that HDAC6 is constitutively present in the mouse retina, and in the cone-like mouse cell line 661W...
August 31, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29048172/effects-of-different-lipophilized-ferulate-esters-in-fish-oil-enriched-milk-partitioning-interaction-protein-and-lipid-oxidation
#5
Xujian Qiu, Charlotte Jacobsen, Pierre Villeneuve, Erwann Durand, Ann-Dorit Moltke Sørensen
Antioxidant effects of ferulic acid and lipophilized ferulate esters were investigated in fish oil-enriched milk. Methyl ferulate (C1) and ethyl ferulate (C2) more efficiently prevented lipid oxidation than dodecyl ferulate (C12) did, followed by ferulic acid (C0). The combination of C1 or C2 with C12 could have a "synergistic" effect indicated by peroxide value, hexanal, and 1-penten-3-ol analysis results. These antioxidants also showed protein oxidation inhibition effects. The most effective antioxidants (C1 and C2) had the highest concentration in the precipitate phase but the lowest concentration in the aqueous phase, which was the opposite of the partitioning of C0...
October 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29047089/redox-mechanisms-influencing-cgmp-signaling-in-pulmonary-vascular-physiology-and-pathophysiology
#6
Dhara Patel, Anand Lakhkar, Michael S Wolin
The soluble form of guanylate cyclase (sGC) and cGMP signaling are major regulators of pulmonary vasodilation and vascular remodeling that protect the pulmonary circulation from hypertension development. Nitric oxide, reactive oxygen species, thiol and heme redox, and heme biosynthesis control mechanisms regulating the production of cGMP by sGC. In addition, a cGMP-independent mechanism regulates protein kinase G through thiol oxidation in manner controlled by peroxide metabolism and NADPH redox. Multiple aspects of these regulatory processes contribute to physiological and pathophysiological regulation of the pulmonary circulation, and create potentially novel therapeutic targets for the treatment of pulmonary vascular disease...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29047036/the-falconoid-luteolin-mitigates-the-myocardial-inflammatory-response-induced-by-high-carbohydrate-high-fat-diet-in-wistar-rats
#7
Nashwa Abu-Elsaad, Amr El-Karef
Luteolin is a major component of many medicinal plants and traditional medicines. The current study aims at testing its protective effect against high-carbohydrate/high-fat (HCHF) diet-induced cardiac dysfunction in rats. Male Wistar rats were divided into six groups as follows: control group that received standard rat chow, group received HCHF diet (~ 30% carbohydrate and 42% fat) daily for 16 weeks, and four groups received HCHF diet concurrently with luteolin (10, 25, 50 or 100 mg/kg; 10% w/v suspension in 0...
October 19, 2017: Inflammation
https://www.readbyqxmd.com/read/29046493/sp-current-global-standards-for-chemical-protective-clothing-how-to-choose-the-right-protection-for-the-right-job
#8
Eric VAN Wely
The first standards for chemical protective clothing (CPC) emerged mid to late 1980's and have evolved since as most standards are revisited every 5 years. Over the past years, we have also seen a strengthening of the chemical and worker protection legislation around the globe (various forms of REACH) but also protection of workers. The most prevalent standards originate under the auspices of the International Standards Organisation (ISO), European Committee for Standardisation (CEN) or under various US standards organisations (e...
October 17, 2017: Industrial Health
https://www.readbyqxmd.com/read/29046378/fluctuating-seawater-ph-pco2-regimes-are-more-energetically-expensive-than-static-ph-pco2-levels-in-the-mussel-mytilus-edulis
#9
Stephanie Mangan, Mauricio A Urbina, Helen S Findlay, Rod W Wilson, Ceri Lewis
Ocean acidification (OA) studies typically use stable open-ocean pH or CO2 values. However, species living within dynamic coastal environments can naturally experience wide fluctuations in abiotic factors, suggesting their responses to stable pH conditions may not be reflective of either present or near-future conditions. Here we investigate the physiological responses of the mussel Mytilus edulis to variable seawater pH conditions over short- (6 h) and medium-term (2 weeks) exposures under both current and near-future OA scenarios...
October 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29045922/the-impact-of-expired-commercial-drugs-on-non-target-marine-species-a-case-study-with-the-use-of-a-battery-of-biomarkers-in-hemocytes-of-mussels
#10
Nektarios Politakis, Alexia Belavgeni, Ioanna Efthimiou, Nikolina Charalampous, Chara Kourkouta, Stefanos Dailianis
The present study investigated the effects of two expired commercial medicines, like Buscopan Plus and Mesulid, commonly classified as household medical wastes, on hemocytes of mussel Mytilus galloprovincialis. Mussel hemocytes' lysosomal membrane stability (in terms of neutral red retention assay), superoxide anions (O2(·)(-)) and nitric oxides (NO, in terms of nitrites) production, lipid peroxidation (in terms of malondialdehyde/MDA content) and the formation of nuclear abnormalities (using the micronucleus/MN assay) were assessed in hemocytes of mussels treated for 7 days with appropriate amounts of each drug (the concentrations of active substances were considered in each case, due to the absence of data related with the excipients) as well as in hemocytes of post-treated/recovered mussels (7 days post-treatment/recovery period)...
October 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29044129/priming-with-fgf2-stimulates-human-dental-pulp-cells-to-promote-axonal-regeneration-and-locomotor-function-recovery-after-spinal-cord-injury
#11
Kosuke Nagashima, Takahiro Miwa, Hitomi Soumiya, Daisuke Ushiro, Tomoko Takeda-Kawaguchi, Naritaka Tamaoki, Saho Ishiguro, Yumi Sato, Kei Miyamoto, Takatoshi Ohno, Masatake Osawa, Takahiro Kunisada, Toshiyuki Shibata, Ken-Ichi Tezuka, Shoei Furukawa, Hidefumi Fukumitsu
Human dental pulp cells (DPCs), adherent cells derived from dental pulp tissues, are potential tools for cell transplantation therapy. However, little work has been done to optimize such transplantation. In this study, DPCs were treated with fibroblast growth factor-2 (FGF2) for 5-6 consecutive serial passages and were transplanted into the injury site immediately after complete transection of the rat spinal cord. FGF2 priming facilitated the DPCs to promote axonal regeneration and to improve locomotor function in the rat with spinal cord injury (SCI)...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043787/rate-of-lipid-peroxyl-radical-production-during-cellular-homeostasis-unravelled-via-fluorescence-imaging
#12
Lana E Greene, Richard Lincoln, Gonzalo Cosa
Reactive oxygen species (ROS) and their associated byproducts have been traditionally associated with a range of pathologies. It is now believed however, that at basal levels, these molecules also play a beneficial cellular function in the form of cell signalling and redox regulation. Critical to elucidating their physiological role is the opportunity to visualize and quantify the production of ROS with spatiotemporal accuracy. Armed with a newly developed, extremely sensitive fluorogenic α-tocopherol analogue (H4BPMHC), we report herein the observation of steady concentrations of lipid peroxyl radicals produced in live cell imaging conditions...
October 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29043218/evaluation-of-antioxidant-and-antimicrobial-activities-of-ethanol-extracts-of-three-kinds-of-strawberries
#13
Semeneh Seleshe, Jong Seok Lee, Sarah Lee, Hye Jin Lee, Ga Ryun Kim, Joohong Yeo, Jong Yea Kim, Suk Nam Kang
The antioxidant and antimicrobial activities of three kinds of strawberry ethanol extracts from Robus corchorifolius L. f. (RCL), Rubus parvifolius L. var. parvifolius (RPL), and Duchesnea chrysantha Miq. (DCM) were investigated. The RPL was highest (P<0.05) in phenolic, flavonoid, and anthocyanin contents. 2,2-Diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activities of RPL and DCM extracts were higher than that of RCL (P<0.05). Hydrogen peroxide scavenging activity of RPL was high compared to DCM and RCL (P<0...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29042734/influence-of-bleaching-regimen-and-time-elapsed-on-microtensile-bond-strength-of-resin-composite-to-enamel
#14
Fulya Toksoy Topcu, Ugur Erdemir, Emre Ozel, Murat Tiryaki, Elif Aybala Oktay, Esra Yildiz
OBJECTIVES: The aim of this study was to evaluate the effects of time elapsed since bleaching and different bleaching regimens on the microtensile bond strength of resin composite to enamel. METHODOLOGY: Forty flattened buccal enamel surfaces were divided into four groups: An unbleached (control) group and three bleaching groups. Control group specimens were not subjected to a bleaching regimen (Group 1), while those in the bleaching groups were bleached as follows: opalescence 10% (Group 2), whiteness perfect 16% (Group 3), and whiteness hydrogen peroxide 35% (Group 4)...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042590/effects-of-short-term-heat-shock-and-physiological-responses-to-heat-stress-in-two-bradysia-adults-bradysia-odoriphaga-and-bradysia-difformis
#15
Guodong Zhu, Ming Xue, Yin Luo, Guixia Ji, Fang Liu, Haipeng Zhao, Xia Sun
Bradysia odoriphaga and Bradysia difformis are devastating pests of vegetable, ornamental crops and edible mushrooms causing significant losses. Temperature may be an important factor restricting their population abundance in the summer. To determine the effects of short-term heat shock on adults, their survival, longevity and fecundity data were collected, and antioxidant responses and heat shock protein expression levels were examined. Our results indicated that the survival rates of Bradysia adults decreased rapidly after heat shock ≥36 °C, and the longevity and reproductive capacities were significantly inhibited, indicating that short-term heat shock had lethal and sub-lethal effects...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042581/immunoproteasome-subunit-%C3%A3-5i-lmp7-deficiency-in-atherosclerosis
#16
Bernd Hewing, Antje Ludwig, Cristian Dan, Max Pötzsch, Carmen Hannemann, Andreas Petry, Dilyara Lauer, Agnes Görlach, Elena Kaschina, Dominik N Müller, Gert Baumann, Verena Stangl, Karl Stangl, Nicola Wilck
Management of protein homeostasis by the ubiquitin-proteasome system is critical for atherosclerosis development. Recent studies showed controversial results on the role of immunoproteasome (IP) subunit β5i/LMP7 in maintenance of protein homeostasis under cytokine induced oxidative stress. The present study aimed to investigate the effect of β5i/LMP7-deficiency on the initiation and progression of atherosclerosis as a chronic inflammatory, immune cell driven disease. LDLR(-/-)LMP7(-/-) and LDLR(-/-) mice were fed a Western-type diet for either 6 or 24 weeks to induce early and advanced stage atherosclerosis, respectively...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042086/effects-of-heat-and-cadmium-exposure-on-stress-related-responses-in-the-liver-of-female-zebrafish-heat-increases-cadmium-toxicity
#17
Sai-Nan Guo, Jia-Lang Zheng, Shuang-Shuang Yuan, Qing-Ling Zhu
In this study, female zebrafish (Danio rerio) were exposed to 26°C or 34°C, 0 or 197μg/L cadmium (Cd), singly or in combination for 7days. Multiple stress-related indicators were evaluated in the liver. Mortality, lipid peroxidation (LPO) and ultrastructural damage increased significantly by Cd exposure alone, and were not affected by heat alone. Interestingly, the combined exposure increased LPO, ultrastructural damage, and mortality compared with Cd exposure alone. The results indicated that elevated temperature increased Cd toxicity, which could be explained by several reasons...
October 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29041938/development-of-breath-test-for-pneumoconiosis-a-case-control-study
#18
Hsiao-Yu Yang, Ruei-Hao Shie, Che-Jui Chang, Pau-Chung Chen
BACKGROUND: Lipid peroxidation plays an important role in the pathogenesis of pneumoconiosis. Volatile organic compounds (VOCs) generated from lipid peroxidation might be used to detect pneumoconiosis. The objective of this study was to develop a breath test for pneumoconiosis. METHODS: A case-control study was designed. Breath and ambient air were analysed by gas chromatography/mass spectrometry. After blank correction to prevent contamination from ambient air, we used canonical discriminant analysis (CDA) to assess the discrimination accuracy and principal component analysis (PCA) to generate a prediction score...
October 17, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29040959/marantodes-pumilum-kacip-fatimah-enhances-in-vitro-glucose-uptake-in-3t3-l1-adipocyte-cells-and-reduces-pancreatic-complications-in-streptozotocin-nicotinamide-induced-male-diabetic-rats
#19
Siti Hajar Adam, Nelli Giribabu, Noor Mazuin Abu Bakar, Naguib Salleh
Marontades pumilum is claimed to have beneficial effects in the treatment of diabetes mellitus (DM), however the underlying mechanisms were not fully identified. In this study, we hypothesized that M. pumilum could help to enhance cellular glucose uptake and reduces pancreatic complications, which contributed towards its beneficial effects in DM. METHODS: Two parameters were measured (i) rate of glucose uptake by 3T3-L1 adipocyte cells in-vitro (ii) degree of pancreatic destruction in streptozotocin-nicotinamide induced male diabetic rats receiving M...
October 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29040933/evaluation-of-mno2-templated-iron-oxide-coated-diatomites-for-their-catalytic-performance-in-heterogeneous-photo-fenton-like-system
#20
Yi He, De Bin Jiang, De Yi Jiang, Jie Chen, Yu Xin Zhang
Herein, iron oxide-coated diatomites were prepared through hydrothermal synthesis and sacrificial template redox etching reaction. The microstructure characterization results revealed that the Fe2O3 nanorods were uniformly distributed on the surface of diatomite. The effects of diverse synthetic parameters on morphology of as-synthesized Fe2O3@diatomite were investigated. When the reaction time was prolonged from 12h to 24h, the morphology of FeOOH would change from nanorods into nanoflowers. Two different crystal phases of Fe2O3@diatomite were obtained from the FeOOH@diatomite samples calcined under different atmospheres...
October 10, 2017: Journal of Hazardous Materials
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