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Ototoxicity

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https://www.readbyqxmd.com/read/29908243/protective-roles-of-fenofibrate-against-cisplatin-induced-ototoxicity-by-the-rescue-of-peroxisomal-and-mitochondrial-dysfunction
#1
Se-Jin Kim, Channy Park, Joon No Lee, Raekil Park
Cisplatin is an alkylating agent that interferes with DNA replication and kills proliferating carcinogenic cells. Several studies have been conducted to attenuate the side effects of cisplatin; one such side effect in cancer patients undergoing cisplatin chemotherapy is ototoxicity. However, owing to a lack of understanding of the precise mechanism underlying cisplatin-induced side effects, management of cisplatin-induced ototoxicity remains unsolved. We investigated the protective effects of fenofibrate, a PPAR-α activator, on cisplatin-induced ototoxicity...
June 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29908183/mif-protects-against-oxygen-glucose-deprivation-induced-ototoxicity-in-hei-oc1-cochlear-cells-by-enhancement-of-akt-nrf2-ho-1-pathway
#2
Wen-Yan Zhu, Xin Jin, Yong-Chi Ma, Zhi-Biao Liu
Ischemia and oxidative stress play crucial roles in the pathophysiology of sudden sensorineural hearing loss (SSNHL). Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and serves an important role in hearing function. The present study was designed to evaluate the effect of MIF on oxygen-glucose deprivation (OGD)-induced ototoxicity and to elucidate its molecular mechanism. In HEI-OC1 auditory cells, OGD reduced cell viability and increased supernatant lactate dehydrogenase (LDH) and MIF in a time-dependent manner...
June 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29904366/bilateral-vestibular-weakness
#3
REVIEW
Timothy C Hain, Marcello Cherchi, Dario Andres Yacovino
Bilateral vestibular weakness (BVW) is a rare cause of imbalance. Patients with BVW complain of oscillopsia. In approximately half of the patients with BVW, the cause remains undetermined; in the remainder, the most common etiology by far is gentamicin ototoxicity, followed by much rarer entities such as autoimmune inner ear disease, meningitis, bilateral Ménière's disease, bilateral vestibular neuritis, and bilateral vestibular schwannomas. While a number of bedside tests may raise the suspicion of BVW, the diagnosis should be confirmed by rotatory chair testing...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29899689/deficiency-of-duffy-antigen-receptor-for-chemokines-ameliorated-cochlear-damage-from-noise-exposure
#4
Bouchra Edderkaoui, Liana Sargsyan, Alisa Hetrick, Hongzhe Li
Cochlear inflammatory response to various environmental insults, including acoustic and ototoxic overexposures, has been increasingly become a topic of interest. As the immune response is associated with both pathology and protection, targeting specific components of the immune response is expected to dissect the relationships between cellular damage and inflammation-associated protection and repair in the cochlea. Duffy antigen receptor for chemokines (DARC) is a member of a group of atypical chemokine receptors, and essential for chemokine-regulated leukocyte/neutrophil trafficking during inflammation...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29893338/therapeutic-effects-of-oleuropein-on-cisplatin-induced-pancreas-injury-in-rats
#5
Murat Bakir, Fatime Geyikoglu, Kubra Koc, Salim Cerig
Aims: Cisplatin (CIS) is an influential chemotherapeutic agent in the treatment of several types of malignant solid tumors, but its clinical use is related with ototoxicity. Oleuropein (OLE) is a natural antioxidant and scavenging free radicals. Here, we first explore the efficacy of OLE in pancreas against to the toxicity of CIS and also analyses its mechanism. Materials and Methods: Fifty-six Sprague-Dawley rats were equally divided into eight groups, including, control group which received 7 mg/kg/day CIS intraperitoneally (i...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29889716/influence-of-24-diamino-5-phenylthiazole-on-neomycin-ototoxicity-in-cultured-organ-of-corti-explants
#6
Yuexia Li, Yunliang Wu, Hongmei Liu, Xiangxin Lou
Hair cells do not undergo spontaneous regeneration when they are damaged in the mammalian organ of Corti, leading to irreversible hearing loss. Previous studies have shown that 24-diamino-5-phenylthiazole (DAPT), an inhibitor of Notch signaling, plays a major role in inner ear development. However, whether DAPT influences antibiotic-induced hair cell damage remains uncertain. The present study aimed to investigate whether DAPT exerts protective or regenerative effects on neomycin-damaged hair cells. A histological analysis was carried out to assess the number and morphological changes of hair cells in cultured organ of Corti explants...
June 8, 2018: Neuroreport
https://www.readbyqxmd.com/read/29875633/meclofenamic-acid-reduces-reactive-oxygen-species-accumulation-and-apoptosis-inhibits-excessive-autophagy-and-protects-hair-cell-like-hei-oc1-cells-from-cisplatin-induced-damage
#7
He Li, Yongdong Song, Zuhong He, Xiaoyun Chen, Xianmin Wu, Xiaofei Li, Xiaohui Bai, Wenwen Liu, Boqin Li, Shanshan Wang, Yuechen Han, Lei Xu, Daogong Zhang, Jianfeng Li, Renjie Chai, Haibo Wang, Zhaomin Fan
Hearing loss is the most common sensory disorder in humans, and a significant number of cases is due to the ototoxicity of drugs such as cisplatin that cause hair cell (HC) damage. Thus, there is great interest in finding agents and mechanisms that protect HCs from ototoxic drug damage. It has been proposed that epigenetic modifications are related to inner ear development and play a significant role in HC protection and HC regeneration; however, whether the m6 A modification and the ethyl ester form of meclofenamic acid (MA2), which is a highly selective inhibitor of FTO (fatmass and obesity-associated enzyme, one of the primary human demethylases), can affect the process of HC apoptosis induced by ototoxic drugs remains largely unexplored...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29873734/differentiation-and-induced-sensorial-alteration-of-the-coronal-organ-in-the-asexual-life-of-a-tunicate
#8
Lucia Manni, Chiara Anselmi, Paolo Burighel, Margherita Martini, Fabio Gasparini
Tunicates, the sister group of vertebrates, possess a mechanoreceptor organ, the coronal organ, which is considered the best candidate to address the controversial issue of vertebrate hair cell evolution. The organ, located at the base of the oral siphon, controls the flow of seawater into the organism and can drive the "squirting" reaction, i.e., the rapid body muscle contraction used to eject dangerous particles during filtration. Coronal sensory cells are secondary mechanoreceptors and share morphological, developmental and molecular traits with vertebrate hair cells...
June 4, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29867751/acute-bilateral-superior-branch-vestibular-neuropathy
#9
Dario A Yacovino, John B Finlay, Valentina N Urbina Jaimes, Daniel H Verdecchia, Michael C Schubert
The rapid onset of a bilateral vestibular hypofunction (BVH) is often attributed to vestibular ototoxicity. However, without any prior exposure to ototoxins, the idiopathic form of BVH is most common. Although sequential bilateral vestibular neuritis (VN) is described as a cause of BVH, clinical evidence for simultaneous and acute onset bilateral VN is unknown. We describe a patient with an acute onset of severe gait ataxia and oscillopsia with features compatible with acute BVH putatively due to a bilateral VN, which we serially evaluated with clinical and laboratory vestibular function testing over the course of 1 year...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29867750/bilateral-vestibular-dysfunction-associated-with-chronic-exposure-to-military-jet-propellant-type-eight-jet-fuel
#10
Terry D Fife, Michael J A Robb, Kristen K Steenerson, Kamala C Saha
We describe three patients diagnosed with bilateral vestibular dysfunction associated with the jet propellant type-eight (JP-8) fuel exposure. Chronic exposure to aromatic and aliphatic hydrocarbons, which are the main constituents of JP-8 military aircraft jet fuel, occurred over 3-5 years' duration while working on or near the flight line. Exposure to toxic hydrocarbons was substantiated by the presence of JP-8 metabolite n -hexane in the blood of one of the cases. The presenting symptoms were dizziness, headache, fatigue, and imbalance...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29866015/cycloserine-induced-suicidal-tendencies-and-kanamycin-induced-ototoxicity-in-indian-mdr-tb-patient-a-case-report
#11
Manjeet Singh Jangra, Manik Chhabra
INTRODUCTION: Cycloserine and Kanamycin are approved for treatment of multidrug-resistant tuberculosis with good tolerability in Tuberculosis patients and have various labeled adverse reactions but the neuropsychiatric adverse drug reactions with the cycloserine are rarely explained. METHODS: We present a case report on Cycloserine induced Suicidal tendencies and Kanamycin induced decrease in hearing sensation in Indian MDR-TB patient. CASE REPORT: A 55-year-old male patient who was diagnosed with MDR-TB was prescribed with category IV anti-tubercular therapy...
June 4, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29862952/increased-risk-of-aminoglycoside-induced-hearing-loss-in-mdr-tb-patients-with-hiv-coinfection
#12
H Hong, C Budhathoki, J E Farley
SETTING: A high proportion of individuals with multidrug-resistant tuberculosis (MDR-TB) develop permanent hearing loss due to ototoxicity caused by injectable aminoglycosides (AGs). The prevalence of AG-induced hearing loss is greatest in tuberculosis (TB) and human immunodeficiency virus (HIV) endemic countries in sub-Saharan Africa. However, whether HIV coinfection is associated with a higher incidence of AG-induced hearing loss during MDR-TB treatment is controversial. OBJECTIVE: To evaluate the impact of HIV coinfection on AG-induced hearing loss among individuals with MDR-TB in sub-Saharan Africa...
June 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29862415/resistance-to-neomycin-ototoxicity-in-the-extreme-basal-hook-region-of-the-mouse-cochlea
#13
Shelly C Y Lin, Peter R Thorne, Gary D Housley, Srdjan M Vlajkovic
Aminoglycoside ototoxicity results in permanent loss of the sensory hair cells in the mammalian cochlea. It usually begins at the basal turn causing high-frequency hearing loss. Here we describe previously unreported resistance of hair cells to neomycin ototoxicity in the extreme basal (hook) region of the developing cochlea of the C57BL/6 mouse. Organ of Corti explants from mice at postnatal day 3 were incubated (37 °C, 5% CO2 ) in normal culture medium for 19.5 h prior to and after exposure to neomycin (1 mM, 3 h)...
June 4, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29798370/-screening-for-effective-antibiotics-in-chronic-suppurative-otitis-media
#14
Y L Zhu, W X Li, J Li
Objective: To explore the method of screening effective antibiotics in active stage of otitis media, in order to lay ground for rational clinical application of antibiotics in this scenario. Method: The clinical data of 198 patients diagnosed as otitis media were analyzed. Based on the results of bacterial culture and drug sensitivity test of middle ear secretion, the clinical availability and the ototoxicity of corresponding drugs, first and second line drugs were screened to control infection. The therapeutic effect of drugs was summarized...
August 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29798322/-bilateral-vestibulopathy
#15
REVIEW
R Huang, G R Bi
The leading symptoms of bilateral vestibulopathy (BVP) are postural imbalance and unsteadiness of gait, deficits of spatial memory and navigation. The etiology of BVP remains unclear in more than 50% of patients: in these cases neurodegeneration is assumed. Frequent known causes are ototoxicity mainly due to gentamicin, bilateral Menière's disease, autoimmune diseases, meningitis and bilateral vestibular schwannoma, as well as an association with cerebellar degeneration. The diagnosis of BVP is based on a bilaterally reduced or absent function of the vestibulo-ocular reflex (VOR)...
December 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29798299/-etiology-analysis-and-vestibular-assessment-of-bilateral-vestibular-vestibulopathy
#16
Y Lin, L X Gao, L Li, J L Wang, J J Shen, F Sun, J H Qiu, D J Zha
Objective: To define clinical and laboratory characteristics of bilateral vestibulopathy(BVP) and to propose diagnostic criteria of this disorder based on clinical and laboratory vestibular function test findings. Method: Forty-two case series with a clinical suspicion of BVP were retrospectively analyzed, in an attempt to determine etiology. Presenting auditory-vestibular symptoms, bedside dynamic visual acuity tests and laboratory test were reviewed, including bithermal caloric test, rotatory chair tests, video head impulse test (vHIT), vestibular-evoked myogenic potentials (VEMP)...
March 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29798293/-experimental-observation-on-the-effect-of-bone-marrow-mesenchymal-stem-cells-transplanting-cxcr4-over-gentamicin-ototoxicity
#17
S P Huang, X Y Wang, C Fang, X Y Wang, Q Wu
Objective: To observe the survival and migration ability of CXCR4-BMSCs in guinea pig cochlea with gentamycin induced sensorineural hearing loss, and to explore whether SDF-1/CXCR4 axis can mediate bone marrow mesenchymal stem cells (BMSCs) to cochlear homing. Method: BMSCs were isolated and extracted from guinea pigs. A bone marrow mesenchymal stem cell line with overexpression of CXCR4 was established. The animal model of sensorineural deafness was established by intraperitoneal injection of gentamicin[100 mg/(kg·d)]in 50 healthy guinea pigs...
March 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29794799/malignant-external-otitis-following-radiotherapy-for-oral-cancer-a-case-report
#18
Takanori Eguchi, Akihiko Basugi, Ikuyo Kanai, Yukinaga Miyata, Tomomitsu Nasuno, Yoshiki Hamada
RATIONALE: Although an ototoxicity is well-known as adverse event of the radiotherapy, it is not widely known that immunosuppressed patients who underwent radiotherapy in head and neck region have risk of malignant external otitis. PATIENT CONCERNS: A 68-year-old man with diabetes, who had been diagnosed as intraosseous squamous cell carcinoma of the right mandible, underwent surgical resection. He received a total of 60 Gy/30Fr postoperative radiation. Four months after the course of radiation, he suffered from right aural fullness, otalgia and otorrhea...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29791559/sequential-analysis-as-a-tool-for-detection-of-amikacin-ototoxicity-in-the-treatment-of-multidrug-resistant-tuberculosis
#19
Karla Anacleto de Vasconcelos, Silvana Maria Monte Coelho Frota, Antonio Ruffino-Netto, Afrânio Lineu Kritski
OBJECTIVE: To investigate early detection of amikacin-induced ototoxicity in a population treated for multidrug-resistant tuberculosis (MDR-TB), by means of three different tests: pure-tone audiometry (PTA); high-frequency audiometry (HFA); and distortion-product otoacoustic emission (DPOAE) testing. METHODS: This was a longitudinal prospective cohort study involving patients aged 18-69 years with a diagnosis of MDR-TB who had to receive amikacin for six months as part of their antituberculosis drug regimen for the first time...
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29779419/an-evaluation-of-hearing-in-infants-administered-with-colistin-in-the-premature-neonatal-intensive-care-unit
#20
Selman Sarıca, Sadık Yurttutan
AIM: The aim of this study was to investigate the effects of colistin on hearing by evaluating the otoacoustic emission tests and clinical auditory brainstem responses in preterm infants treated with colistin in the neonatal intensive care unit. METHOD: The study included 30 neonates (male: n = 16, female: n = 14) born before 37 weeks who were admitted to the Neonatal Intensive Care Unit at the Kahramanmaras Sutcu Imam Medical Faculty between January 2014 and January 2015 and who were treated with colistin during their time in intensive care because of infection...
May 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
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