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https://www.readbyqxmd.com/read/28209132/urinary-tract-infection-among-fistula-patients-admitted-at-hamlin-fistula-hospital-addis-ababa-ethiopia
#1
Matifan Dereje, Yimtubezinesh Woldeamanuel, Daneil Asrat, Fekade Ayenachew
BACKGROUND: Urinary Tract Infection (UTI) causes a serious health problem and affects millions of people worldwide. Patients with obstetric fistula usually suffer from incontinence of urine and stool, which can predispose them to frequent infections of the urinary tract. Therefore the aim of this study was to determine the etiologic agents, drug resistance pattern of the isolates and associated risk factor for urinary tract infection among fistula patients in Addis Ababa fistula hospital, Ethiopia...
February 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28207789/carbapenem-resistance-and-pathogenicity-of-bovine-acinetobacter-indicus-like-isolates
#2
Peter Klotz, Stephan Göttig, Ursula Leidner, Torsten Semmler, Sandra Scheufen, Christa Ewers
The objective of this study was to characterize blaOXA-23 harbouring Acinetobacter indicus-like strains from cattle including genomic and phylogenetic analyses, antimicrobial susceptibility testing and evaluation of pathogenicity in vitro and in vivo. Nasal and rectal swabs (n = 45) from cattle in Germany were screened for carbapenem-non-susceptible Acinetobacter spp. Thereby, two carbapenem resistant Acinetobacter spp. from the nasal cavities of two calves could be isolated. MALDI-TOF mass spectrometry and 16S rDNA sequencing identified these isolates as A...
2017: PloS One
https://www.readbyqxmd.com/read/28206694/translational-readthrough-generates-new-astrocyte-aqp4-isoforms-that-modulate-supramolecular-clustering-glial-endfeet-localization-and-water-transport
#3
Manuela De Bellis, Francesco Pisani, Maria Grazia Mola, Stefania Rosito, Laura Simone, Cinzia Buccoliero, Maria Trojano, Grazia Paola Nicchia, Maria Svelto, Antonio Frigeri
Regulation of water homeostasis is a central feature of central nervous system pathophysiology. In this context, several lines of evidence suggest a crucial role for the water channel aquaporin-4 (AQP4) and its plasma membrane supramolecular organization as the key element. Here, we demonstrate the expression in tissues of additional isoforms of AQP4 characterized by a C-terminal extension generated by programmed translational readthrough. These extended isoforms (AQP4ex) display a perivascular polarization and expression in dystrophin-dependent pools...
February 16, 2017: Glia
https://www.readbyqxmd.com/read/28203403/clinic-application-of-tissue-engineered-bronchus-for-lung-cancer-treatment
#4
Qiang Tan, Ruijun Liu, Xiaoke Chen, Jingxiang Wu, Yinggen Pan, Shun Lu, Walter Weder, Qingquan Luo
BACKGROUND: Delayed revascularization process and substitute infection remain to be key challenges in tissue engineered (TE) airway reconstruction. We propose an "in-vivo bioreactor" design, defined as an implanted TE substitutes perfused with an intra-scaffold medium flow created by an extracorporeal portable pump system for in situ organ regeneration. The perfusate keeps pre-seeded cells alive before revascularization. Meanwhile the antibiotic inside the perfusate controls topical infection...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28199151/antimicrobial-resistance-percentages-of-salmonella-and-shigella-in-seafood-imported-to-jordan-higher-percentages-and-more-diverse-profiles-in-shigella
#5
Mohammad M Obaidat, Alaa E Bani Salman
This study determined the prevalence and antimicrobial resistance of human-specific ( Shigella spp.) and zoonotic ( Salmonella enterica ) foodborne pathogens in internationally traded seafood. Sixty-four Salmonella and 61 Shigella isolates were obtained from 330 imported fresh fish samples from Egypt, Yemen, and India. The pathogens were isolated on selective media, confirmed by PCR, and tested for antimicrobial resistance. Approximately 79 and 98% of the Salmonella and Shigella isolates, respectively, exhibited resistance to at least one antimicrobial, and 8 and 49% exhibited multidrug resistance (resistance to three or more antimicrobial classes)...
February 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28197394/antibiogram-of-bacteria-isolated-from-automated-teller-machines-in-hamadan-west-iran
#6
Hassan Mahmoudi, Mohammad Reza Arabestani, Mohammad Yousef Alikhani, Iraj Sedighi, Hamed Farhadi Kohan, Mohammad Molavi
Aim: Bacteria are ubiquitous in the environment. In keeping with the continued expansion of urbanization and the growing population, an increasing number of people use automated banking, i.e. automated teller machines (ATMs). The aim of this study was to investigate the bacterial contamination and its antibiotic sensitivity on computer keyboards located at ATMs in Hamadan province, Iran. Method: Out of 360 ATMs at four locations in Hamadan, 96 were randomly selected for this study. The antibiotic susceptibility pattern of all isolates was determined by the agar disk diffusion method using gentamicin (10 µg), vancomycin (30 µg), trimethoprim/sulfamethoxazole (25 µg), amikacin (30 µg), tobramycin (10 µg), cephalotin (30 µg), norfloxacin (5 µg), and ceftizoxim (30 µg) disks...
2017: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/28195096/genotyping-of-clinical-and-environmental-multidrug-resistant-enterococcus-faecium-strains
#7
Leili Shokoohizadeh, Ashraf Mohabati Mobarez, Masoud Alebouyeh, Mohammad Reza Zali, Reza Ranjbar
CONTEXT: Multidrug resistant (MDR) Enterococcus faecium is a nosocomial pathogen and clonal complex 17 (CC17) is the main genetic subpopulation of E. faecium in hospitals worldwide. AIMS: There has thus far been no report of major E. faecium clones in Iranian hospitals. SUBJECTS AND METHODS: The present study analyzed strains of MDR E. faecium obtained from patients and the Intensive Care Unit environments using pulsed field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) to determine the antibiotic resistance patterns and genetic features of the dominant...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28194803/the-current-spectrum-of-contact-sensitization-in-patients-with-chronic-leg-ulcers-or-stasis-dermatitis%C3%A2-%C3%A2-new-data-from-the-information-network-of-departments-of-dermatology-ivdk
#8
Cornelia Erfurt-Berge, Johannes Geier, Vera Mahler
BACKGROUND: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization. OBJECTIVES: To identify the current spectrum of contact allergens in these patients. PATIENTS AND METHODS: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510)...
February 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28192951/identification-and-quantification-of-intravenous-therapy-drugs-using-normal-raman-spectroscopy-and-electrochemical-surface-enhanced-raman-spectroscopy
#9
Stephanie Zaleski, Kathleen A Clark, Madison M Smith, Jan Y Eilert, Mark Doty, Richard P Van Duyne
Errors in intravenous (IV) drug therapies can cause human harm and even death. There are limited label-free methods that can sensitively monitor the identity and quantity of the drug being administered. Normal Raman spectroscopy (NRS) provides a modestly sensitive, label-free, and completely noninvasive means of IV drug sensing. In the case that the analyte cannot be detected within its clinical range with Raman, a label-free surface-enhanced Raman spectroscopy (SERS) approach can be implemented to detect the analyte of interest...
January 30, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28188831/lipoteichoic-acid-synthesis-inhibition-in-combination-with-antibiotics-abrogates-growth-of-multidrug-resistant-enterococcus-faecium
#10
Fernanda L Paganelli, Tim van de Kamer, Ellen C Brouwer, Helen L Leavis, Neil Woodford, Marc J M Bonten, Rob J L Willems, Antoni P A Hendrickx
Enterococcus faecium is a multidrug-resistant (MDR) nosocomial pathogen causing significant morbidity in debilitated patients. New antimicrobials are needed to treat antibiotic-resistant E. faecium infections in hospitalised patients. E. faecium incorporates lipoteichoic acid (LTA) (1,3-polyglycerol-phosphate linked to glycolipid) in its cell wall. The small-molecule inhibitor 1771 [2-oxo-2-(5-phenyl-1,3,4-oxadiazol-2-ylamino)ethyl 2-naphtho[2,1-b]furan-1-ylacetate] specifically blocks the activity of Staphylococcus aureus LtaS synthase, which polymerises 1,3-glycerolphosphate into LTA polymers...
February 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28185962/design-and-evaluation-of-antibiotic-releasing-self-assembled-scaffolds-at-room-temperature-using-biodegradable-polymer-particles
#11
Prasad Admane, Jatin Gupta, Ancy Ij, Robin Kumar, Amulya K Panda
Biodegradable polymer based drug eluting implants offer many advantages such as predictable drug release kinetics, safety, and acceptable drug loading under ambient conditions. Herein, we describe fabrication and evaluation of antibiotic loaded scaffolds for localized delivery and tissue engineering applications. PDLLA particles entrapping gentamycin were formulated using solvent evaporation method and used for scaffold fabrication. Optimization of formulation parameters such as pH of the internal aqueous phase and combination of excipients like glycerol, polyvinyl alcohol (PVA) resulted in high entrapment efficiencies up to 96% of gentamicin in particles with drug load of 16-18μg/mg of polymer particles...
February 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28185940/twisting-electrospun-nanofiber-fine-strips-into-functional-sutures-for-sustained-co-delivery-of-gentamicin-and-silver
#12
Shixuan Chen, Liangpeng Ge, Aubrey Mueller, Mark A Carlson, Matthew J Teusink, Franklin D Shuler, Jingwei Xie
Surgical site infections (SSIs) represent the most common nosocomial infection among surgical patients. In order to prevent SSIs in a sustained manner and lessen side effects, we developed a twisting method for generation of nanofiber-based sutures capable of simultaneous delivery of silver and gentamicin. The prepared sutures are composed of core-sheath nanofibers with gentamicin/pluronic F127 in the core and silver/PCL in the sheath produced by co-axial electrospinning. The diameters of obtained sutures range from ~ 80 μm to ~ 1...
February 6, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28184157/silver-loaded-nanotubular-structures-enhanced-bactericidal-efficiency-of-antibiotics-with-synergistic-effect-in-vitro-and-in-vivo
#13
Na Xu, Hao Cheng, Jiangwen Xu, Feng Li, Biao Gao, Zi Li, Chenghao Gao, Kaifu Huo, Jijiang Fu, Wei Xiong
Antibiotic-resistant bacteria have become a major issue due to the long-term use and abuse of antibiotics in treatments in clinics. The combination therapy of antibiotics and silver (Ag) nanoparticles is an effective way of both enhancing the antibacterial effect and decreasing the usage of antibiotics. Although the method has been proved to be effective in vitro, no in vivo tests have been carried out at present. Herein, we described a combination therapy of local delivery of Ag and systemic antibiotics treatment in vitro in an infection model of rat...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28182844/characterization-of-antibiotic-resistance-genes-from-lactobacillus-isolated-from-traditional-dairy-products
#14
Huiling Guo, Lin Pan, Lina Li, Jie Lu, Laiyu Kwok, Bilige Menghe, Heping Zhang, Wenyi Zhang
Lactobacilli are widely used as starter cultures or probiotics in yoghurt, cheese, beer, wine, pickles, preserved food, and silage. They are generally recognized as safe (GRAS). However, recent studies have shown that some lactic acid bacteria (LAB) strains carry antibiotic resistance genes and are resistant to antibiotics. Some of them may even transfer their intrinsic antibiotic resistance genes to other LAB or pathogens via horizontal gene transfer, thus threatening human health. A total of 33 Lactobacillus strains was isolated from fermented milk collected from different areas of China...
February 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28178315/composition-and-pathogenic-potential-of-a-microbial-bioremediation-product-used-for-crude-oil-degradation
#15
Azam F Tayabali, Gordon Coleman, Jennifer Crosthwait, Kathy C Nguyen, Yan Zhang, Philip Shwed
A microbial bioremediation product (MBP) used for large-scale oil degradation was investigated for microbial constituents and possible pathogenicity. Aerobic growth on various media yielded >108 colonies mL-1. Full-length 16S rDNA sequencing and fatty acid profiling from morphologically distinct colonies revealed ≥13 distinct genera. Full-length 16S rDNA library sequencing, by either Sanger or long-read PacBio technology, suggested that up to 21% of the MBP was composed of Arcobacter. Other high abundance microbial constituents (>6%) included the genera Proteus, Enterococcus, Dysgonomonas and several genera in the order Bacteroidales...
2017: PloS One
https://www.readbyqxmd.com/read/28174311/a-numbers-game-ribosome-densities-bacterial-growth-and-antibiotic-mediated-stasis-and-death
#16
Bruce R Levin, Ingrid C McCall, Véronique Perrot, Howard Weiss, Armen Ovesepian, Fernando Baquero
: We postulate that the inhibition of growth and low rates of mortality of bacteria exposed to ribosome-binding antibiotics deemed bacteriostatic can be attributed almost uniquely to these drugs reducing the number of ribosomes contributing to protein synthesis, i.e., the number of effective ribosomes. We tested this hypothesis with Escherichia coli K-12 MG1655 and constructs that had been deleted for 1 to 6 of the 7 rRNA (rrn) operons. In the absence of antibiotics, constructs with fewer rrn operons have lower maximum growth rates and longer lag phases than those with more ribosomal operons...
February 7, 2017: MBio
https://www.readbyqxmd.com/read/28171222/effect-of-long-term-cultivation-on-morphological-and-biological-characteristics-of-human-periodontal-ligament-stem-cells
#17
(no author information available yet)
OBJECTIVES: Recently, it was demonstrated that human periodontal ligament stem cells have great potential for tissue engineering and regenerative medicine not limited to oro-maxillofacial region. They are easily accessible and they may be expanded under in vitro conditions. In this study we assessed the effect of long-term cultivation on the selected biological and morphological properties of human periodontal ligament stem cells. METHODS: Periodontal tissues were obtained from normal impacted third molars of healthy donors (n=5; aged 18-27 years), after obtaining informed consent...
October 8, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28167857/high-frequency-of-vancomycin-resistant-enterococcus-faecalis-in-children-an-alarming-concern
#18
F Sabouni, Z Movahedi, S Mahmoudi, B Pourakbari, S Keshavarz Valian, S Mamishi
INTRODUCTION: Enterococcus spp. is considered as important etiological agents of nosocomial infections. However, a little is known about the epidemiology of vancomycin resistant Enterococcus faecalis (VREF). The aim of this study was to investigate the frequency of VREF and detecting of two prevalent resistance genes (vanA, vanB) at Children Medical Center Hospital, an Iranian referral pediatric Hospital. MATERIALS AND METHODS: During January 2013 to December 2013, 180 E...
December 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28167856/prevalence-of-high-level-gentamicin-resistant-enterococcus-faecalis-and-enterococcus-faecium-in-an-iranian-hospital
#19
M Emaneini, B Khoramian, F Jabalameli, R Beigverdi, K Asadollahi, M Taherikalani, A R Lari
This study was designed to determine the molecular characteristics and antimicrobial resistance of enterococcal strains isolated from patients admitted to an Iranian Hospital. Enterococcal strains were isolated from the burn patients. All strains were screened for genes encoding resistance to aminoglycoside [aac(6')-Ie-aph(2'')-Ia, aph (3'), ant (4')], resistance to vancomycin (vanA, vanB), resistance to tetracycline (tetK, tetL, tetM, tetO), and resistance to erythromycin (ermA, ermB, ermC) by PCR and multiplex PCR-based methods...
December 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28166707/isolation-and-partial-characterization-of-streptococcus-suis-from-clinical-cases-in-cattle
#20
Ogi Okwumabua, Hanna Peterson, Hui-Min Hsu, Phil Bochsler, Melissa Behr
Sixteen isolates of gram-positive, coccoid bacteria were obtained from clinical cases of diverse conditions in cattle and identified as Streptococcus suis using 16S ribosomal DNA gene sequencing and other bacterial identification methods. None of the isolates could be assigned to any of the known S. suis capsular types. Virulence-associated gene profiling that targeted muramidase-released protein, extracellular protein factor, suilysin, 89-kb pathogenicity island, and arginine deiminase ( arcA) genes were negative except for 1 isolate that was arcA positive...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
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