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Gentamicin

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https://www.readbyqxmd.com/read/29783252/the-analytical-prognosis-of-the-susceptibility-to-aminoglycosides-and-doxycycline-inacinetobacter-baumanniiisoolated-from-burns-of-intensive-care-unit-patients
#1
Vasyl I Nahaichuk, Oleksandr A Nazarchuk, Neonila I Osadchuk, Dmytro V Dmytriiev, Halyna H Nazarchuk
OBJECTIVE: Introduction: Clinical strains of A.baumannii are becoming highly important in hospital-acquired infections, especially because of their association with low susceptibility to antibiotics, which requires in-depth study with a prognostic determination of the dynamics of antimicrobial efficacy of antibiotics. The aim was to investigate of prognostic models of aminoglycoside antibiotics effectiveness on the basis of the mathematical analysis of real susceptibility of A.baumannii clinical strains, isolated from patients in BICU...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782954/comparison-between-disk-diffusion-and-agar-dilution-methods-to-determine-in-vitro-susceptibility-of-corynebacterium-spp-clinical-isolates-and-update-of-their-susceptibility
#2
Claudia Barberis, Eugenia Sandoval, Carlos Hernán Rodriguez, María Soledad Ramírez, Angela Famiglietti, Marisa Almuzara, Carlos Vay
INTRODUCTION: Although Corynebacterium species are part of the skin and mucous membranes microbiota, human infections caused by Corynebacterium spp. have been reported and the multidrug resistance pattern of the recovered isolates was emphasized. Due to the usefulness of disk diffusion in daily practice, the purpose of this work was to compare disk diffusion against agar dilution to determine disk diffusion breakpoints and to review the antimicrobial susceptibility of the most frequent Corynebacterium spp...
May 18, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29781595/-results-of-the-implementation-of-an-antimicrobial-stewardship-program-in-the-gerencia-de-atenci%C3%A3-n-integrada-of-alcazar-de-san-juan-castilla-la-mancha
#3
M A Asencio Egea, O Herráez Carrera, M Huertas Vaquero, H D Patiño Ortega, M Franco Huerta, P Alcázar Carmona, M C Conde García, C Muñoz-Cuevas, C Román Ortiz, J Gaitán Pitera, R Carranza González, J R Barberá
OBJECTIVE: Our aim was to evaluate the efficiency of an ASP after its implementation in 2016 in a Spanish hospital quality system. METHODS: Efficiency of the ASP was measured by process and outcome indicators at the level of the patient's quality of life, antimicrobial consumption and percentage of resistance to them during the 2016-2017 period. In 2017, the failures mode and effects analysis (FMEA) methodology was applied. An annual satisfaction survey was conducted...
May 18, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29781085/effect-of-hypothermia-treatment-on-gentamicin-pharmacokinetics-in-neonates-with-hypoxic-ischaemic-encephalopathy-a-systematic-review-and-meta-analysis
#4
REVIEW
D W Choi, J H Park, S Y Lee, S H An
WHAT IS KNOWN AND OBJECTIVE: Hypothermia is the current standard therapy for asphyxiated neonates with hypoxic-ischaemic encephalopathy (HIE). Gentamicin is used for the empirical treatment of early-onset neonatal sepsis. We investigated the influence of hypothermia treatment on gentamicin pharmacokinetics and suggested the appropriate dosing recommendations for gentamicin in neonates with HIE receiving hypothermia treatment. METHODS: We searched studies published until February 2017 in MEDLINE using PubMed, EMBASE and the Cochrane Library...
May 20, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29779148/in-vitro-virulence-characteristics-of-rare-serovars-of-salmonella-enterica-isolated-from-sand-lizards-lacerta-agilis-l
#5
Joanna Mokracka, Sylwia Krzymińska, Danił Ałtunin, Dariusz Wasyl, Ryszard Koczura, Krzysztof Dudek, Monika Dudek, Zofia Anna Chyleńska, Anna Ekner-Grzyb
The aim of this study was to estimate virulence potential of Salmonella enterica strains colonizing the gut of free-living sand lizards (Lacerta agilis L.). The strains belonged to three Salmonella serovars: Abony, Schleissheim, and Telhashomer. Adhesion and invasion abilities of the strains were determined in quantitative assays using the gentamicin protection method. Induction of apoptosis was assessed using HeLa cell monolayers. PCR assays were used for detection of 26 virulence genes localised within mobile elements: pathogenicity islands, virulence plasmids, and prophage sequences...
May 19, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29778432/the-effect-of-exposure-to-sub-inhibitory-concentrations-of-hypochlorite-and-quaternary-ammonium-compounds-on-antimicrobial-susceptibility-of-pseudomonas-aeruginosa
#6
Aya Mahmoud Nasr, Marwa Salah Mostafa, Heba Hamed Arnaout, Amal Ali Ali Elshimy
BACKGROUND: Pseudomonas is a group of medically important species that inhabit a wide range of niches, including hospital environments. Controversies have emerged about the possible link between improper use of disinfectants and the emergence of antibiotic resistance in bacteria. The aim of this study was to assess the effect of exposure of antibiotic-susceptible Pseudomonas isolates to sub-inhibitory concentrations of 2 disinfectants-didecyldimonium chloride and sodium hypochlorite-on their antibiotic susceptibility patterns...
May 16, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29775786/is-mic-increase-of-meropenem-against-klebsiella-pneumoniae-carbapenemase-kpc-producing-klebsiella-pneumoniae-correlated-with-the-increase-of-resistance-rates-against-some-other-antibiotics-with-gram-negative-activity
#7
Piergiorgio Cojutti, Assunta Sartor, Matteo Bassetti, Claudio Scarparo, Federico Pea
OBJECTIVE: To assess MIC distribution for meropenem and the other antibiotics with Gram-negative activity against KPC-Kp clinical isolates collected at our hospital in 2013-2016. METHODS: Susceptibility of KPC-Kp strains was tested by broth microdilution method, using customized 96-well plates, and was interpreted according to the EUCAST recommendations. RESULTS: Among 169 consecutive KPC-Kp clinical isolates 26.6% were susceptible to meropenem...
May 15, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29774093/distribution-of-virulence-associated-genes-and-antimicrobial-susceptibility-in-clinical-acinetobacter-baumannii-isolates
#8
Chao Liu, Yaowen Chang, Ying Xu, Yun Luo, Linrong Wu, Zhanjun Mei, Shigang Li, Rui Wang, Xu Jia
Acinetobacter baumannii is undoubtedly one of the most clinically significant pathogens. The multidrug resistance and virulence potential of A. baumannii are responsible for hospital-acquired nosocomial infections. Unlike numerous investigations on the drug-resistant epidemiology of A. baumanni , virulence molecular epidemiology is less studied. Here, we collected 88 A. baumannii clinical isolates, tested their antimicrobial susceptibility to 10 commonly used antibiotics and analyzed the distribution of 9 selected virulence-associated genes, aims to investigate the primary characteristics of the virulence-associated genes that exist in clinically multidrug resistant (MDR) and non-MDR isolates of A...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773450/acromioclavicular-joint-septic-arthritis-in-an-immunocompetent-child-a-case-report
#9
Saurabh Dutt, Jeetendra Lodhi, Vinod Kumar, Abhishek Kashyap
Septic arthritis of acromioclavicular (AC) joint is a rare entity. It is generally seen in patients who are immunocompromised. Only 15 cases have been reported till now, with only one case series of 6 patients. We report a case of septic arthritis of AC joint in an immunocompetent child. A 9 years old girl presented with history of pain in left shoulder for 4 days associated with fever. No history suggestive of any immunocompromised state was complained. On local examination, a swelling of around 3 cm in diameter was found over left AC joint region with raised local temperature, tenderness on palpation and positive response in fluctuation test...
March 23, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29772761/high-concentrations-of-sodium-chloride-improve-microbicidal-activity-of-ibuprofen-against-common-cystic-fibrosis-pathogens
#10
Adrián J Muñoz, Roxana V Alasino, Ariel G Garro, Valeria Heredia, Néstor H García, David C Cremonezzi, Dante M Beltramo
Ibuprofen (IBU-H), a widely used anti-inflammatory, also shows a marked antimicrobial effect against several bacterial species, including those involved in cystic fibrosis such as Pseudomona aeruginosa , methicillin resistant Staphylococcus aureus and Burkholderia cepacia complex. Additionally, our results show significant synergy between water soluble Na-ibuprofen (IBU-Na) and ionic strength. Salt concentrations above 0.5 M modify the zeta potential promoting the action of Na-IBU; thus, with 1 M sodium chloride, IBU-Na is ten times more efficient than in the absence of ionic strength, and the minimum effective contact time is reduced from hours to minutes...
May 17, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29772696/the-effect-of-negative-pressure-wound-therapy-with-and-without-instillation-on-mature-biofilms-in-vitro
#11
Shamaila Tahir, Matthew Malone, Honghua Hu, Anand Deva, Karen Vickery
BACKGROUND: To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. METHODS: Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC biofilm reactor for 3 days. Coupons containing biofilms were placed in a sterile petri dish and sealed using NPWT or NPWTi. Coupons were exposed to treatment for 24 h with NPWT alone or with instillation of: Povidone iodine solution (PVP-I) (10% w / v equivalent to 1% w / v available iodine, BETADINE® , Mundipharma, Singapore), surfactant based antimicrobial solution with polyhexamethylene biguanide (SBPHMB) (Prontosan® , B Braun Medical, Melsungen, Germany), Gentamicin 1 µg/mL (GM) (G1264 Sigma-Aldrich Pty Ltd...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29772394/antimicrobial-resistance-and-genetic-lineages-of-faecal-enterococci-of-wild-birds-emergence-of-vana-and-vanb2-harboring-enterococcus-faecalis
#12
Houssem Ben Yahia, Sarra Chairat, Nabil Hamdi, Haythem Gharsa, Rym Ben Sallem, Sara Ceballos, Carmen Torres, Karim Ben Slama
Migrating birds have been implicated in pathogen dissemination over long-distances. The lack of data on birds' intestinal microbiota makes these animals a promising path to understand their potential role in the transmission of antibiotic resistant bacteria. This work aims to study the diversity of enterococci species and to analyze the antimicrobial resistant phenotypes/genotypes, as well as the genetic lineages of isolates obtained from faecal and pellet samples of colonial wild birds in Tunisia. Seventy-nine enterococci were recovered of 150 wild bird, after inoculation of samples in Slanetz-Bartley agar, and were identified as E...
May 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29767074/occurrence-of-clostridium-perfringens-contamination-in-poultry-feed-ingredients-isolation-identification-and-its-antibiotic-sensitivity-pattern
#13
Shanmugasundaram Udhayavel, Gopalakrishnamurthy Thippichettypalayam Ramasamy, Vasudevan Gowthaman, Shanmugasamy Malmarugan, Kandasamy Senthilvel
This work has been undertaken to study the occurrence of Clostridium perfringens contamination in the poultry feed ingredients and find out its in-vitro antibiotic sensitivity pattern to various antimicrobial drugs. Two hundred and ninety-eight poultry feed ingredient samples received at Poultry Disease Diagnosis and Surveillance Laboratory, Namakkal, Tamil Nadu in South India were screened for the presence of C. perfringens . The organisms were isolated in Perfringens agar under anaerobic condition and subjected to standard biochemical tests for confirmation...
September 2017: Animal nutrition
https://www.readbyqxmd.com/read/29765781/bactericidal-and-cytotoxic-activities-of-polyphenol-extracts-from-solanum-tuberosum-spp-tuberosum-and-spp-andigena-cultivars-on-escherichia-coli-and-human-neuroblastoma-sh-sy5y-cells-in-vitro
#14
María Ximena Silveyra, María Luciana Lanteri, Rocío Belén Damiano, Adriana Balbina Andreu
Potatoes ( Solanum tuberosum L.) are a good source of dietary antioxidant polyphenols. This study investigated the potential antioxidant, bactericidal, and cytotoxic activities in vitro of the phenolic compounds present in tubers of one S. tuberosum spp. tuberosum (Summerside), and three S. tuberosum spp. andigena (landraces Moradita, Waicha, and Santa María) cultivars. Both the content of phenolic acids, chlorogenic acids (CGAs) being the most abundant, and the antioxidant activity were higher in extracts from skin than from flesh...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29765440/prevalence-of-bacteria-and-fungi-in-samples-of-cornea-preservation-fluid
#15
Grażyna Broniek, Ewa Langwińska-Wośko, Małgorzata Sybilska, Jerzy Szaflik, Jacek P Szaflik, Marta Wróblewska
Introduction: Recipients of corneal transplants are at risk of healthcare-associated infections, which, apart from other causes of surgical site infections, may also occur as a result of the transfer of infected corneal tissue. In this study we assessed the risk of bacterial and fungal infections based on the results of routine microbiological testing of cornea preservation fluid samples. Material and methods: We examined a total of 725 samples of corneal preservation fluid, obtained during a period of 3 years (2011-2013)...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764503/bacteriological-profile-of-neonatal-sepsis-and-antibiotic-susceptibility-pattern-of-isolates-admitted-at-kanti-children-s-hospital-kathmandu-nepal
#16
Nikita Singh Yadav, Saroj Sharma, Dhiraj Kumar Chaudhary, Prabhat Panthi, Pankaj Pokhrel, Anil Shrestha, Pappu Kumar Mandal
OBJECTIVE: Neonatal sepsis is a major cause of morbidity and mortality of newborns (< 1 month of age). Septicemia and drug resistance is a predominant issue for neonatal death in Nepal. This study is intended to find bacteriological profile of neonatal sepsis and antibiotic susceptibility pattern of the isolates from neonates at Kanti Children's Hospital, Kathmandu, Nepal. RESULTS: Out of 350 suspected cases of neonatal sepsis, 59 (16.9%) cases showed positive blood culture...
May 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29762774/occurrence-and-antimicrobial-susceptibility-of-campylobacter-spp-on-fresh-and-refrigerated-chicken-meat-products-in-central-italy
#17
P Casagrande Proietti, S Pergola, S Bellucci, L Menchetti, D Miraglia, M P Franciosini
This study investigated the presence and the level of Campylobacter spp. contamination in 41 thigh samples (with skin) and 37 skinless breast samples collected at the end of slaughter (T1) and after 10 day period at refrigeration temperature (4°C) (T2), corresponding to their commercial shelf life. The isolates were phenotypically classified as Campylobacter spp. and successively identified by conventional multiplex PCR. The antimicrobial susceptibility of the isolates from fresh thigh and breast samples was also determined via the microdilution method (MIC) in Eucamp microtitre plates with known scalar concentrations of: gentamicin (GEN), streptomycin (ST), ciprofloxacin (CIP), tetracycline (TET), erythromycin (ERY), and nalidixic acid (NA)...
May 11, 2018: Poultry Science
https://www.readbyqxmd.com/read/29762076/the-degeneration-of-the-vestibular-efferent-neurons-after-intratympanic-gentamicin-administration
#18
Qianru Wu, Yibo Zhang, Chunfu Dai, Yu Kong, Lijun Pan
Intratympanic gentamicin (ITG) has been used to treat refractory Ménière's disease. Disequilibrium after ITG was still a challenge for some patients, and the underlying mechanism is poorly understood. Our previous study demonstrated that gentamicin distributed in the bilateral vestibular efferent neurons (VEN) after ITG; however, does it lead to VEN damage and cause further disequilibrium in patients following ITG? In this study, we observed severe damaged gentamicin-positive neurons of VEN and severe fractured myelin layer plates around neural fibers when viewed under transmission electron microscopy at day 3 after ITG...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29761517/pharmacokinetics-of-intravenous-gentamicin-in-healthy-young-adult-compared-to-aged-alpacas
#19
A Gestrich, D Bedenice, M Ceresia, I Zaghloul
The study objective was to evaluate the effects of age on aminoglycoside pharmacokinetics in eight young-adult (<4 years) and eight aged (≥14 years) healthy alpacas, receiving a single 6.6 mg/kg intravenous gentamicin injection. Heparinized plasma samples were obtained at designated time points following drug administration and frozen at -80°C until assayed by a validated immunoassay (QMS® ). Compartmental and noncompartmental analyses of gentamicin plasma concentrations versus time were performed using WinNonlin (v6...
May 14, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29761068/antibiotic-containing-bone-substitute-in-major-hip-surgery-a-long-term-gentamicin-elution-study
#20
Mindaugas Stravinskas, Malin Nilsson, Peter Horstmann, Michael Mørk Petersen, Sarunas Tarasevicius, Lars Lidgren
Objectives: The objective is to present the antibiotic elution from a locally implanted gentamicin containing hydroxyapatite and calcium sulphate bone substitute with an extended follow up of 30 days. We also compare the pharmacokinetics of the ceramic bone substitute with a published study on gentamicin containing poly (methyl methacrylate) (PMMA) bone cement used in primary total hip arthroplasty. Methods: Gentamicin release was measured in the urine for a month and the serum for 4 days in 10 patients operated for trochanteric hip fractures and 10 patients in uncemented hip revisions...
2018: Journal of Bone and Joint Infection
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