keyword
https://read.qxmd.com/read/38622462/differences-between-patients-with-heartburn-refractory-to-vonoprazan-and-those-refractory-to-proton-pump-inhibitors
#21
JOURNAL ARTICLE
Tomoaki Matsumura, Michiko Sonoda, Kenichiro Okimoto, Hang Viet Dao, Satsuki Takahashi, Naoki Akizue, Ryosuke Horio, Chihiro Goto, Akane Kurosugi, Tatsuya Kaneko, Yuki Ohta, Takashi Taida, Atsuko Kikuchi, Mai Fujie, Jun Kato, Naoya Kato
BACKGROUND: Vonoprazan, a potassium-competitive acid blocker, demonstrates more potent acid inhibition than proton pump inhibitors (PPIs). This study aimed to evaluate the effect of vonoprazan in patients with unproven gastroesophageal reflux disease (GERD) by comparing patients with vonoprazan-refractory heartburn with those with PPI-refractory heartburn. METHODS: This study included 104 consecutive patients with vonoprazan- or PPI-refractory heartburn (52 patients each), no erosive esophagitis on endoscopy and who underwent combined multichannel intraluminal impedance-pH (MII-pH) testing with vonoprazan/PPI discontinuation...
April 15, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38622198/loss-of-srebp-1c-ameliorates-iron-induced-liver-fibrosis-by-decreasing-lipocalin-2
#22
JOURNAL ARTICLE
Eun-Ho Lee, Jae-Ho Lee, Do-Young Kim, Young-Seung Lee, Yunju Jo, Tam Dao, Kyung Eun Kim, Dae-Kyu Song, Ji Hae Seo, Young-Kyo Seo, Je Kyung Seong, Changjong Moon, Eugene Han, Mi Kyung Kim, Seungwan Ryu, Minsang Shin, Gu Seob Roh, Hye Ra Jung, Timothy F Osborne, Dongryeol Ryu, Tae-Il Jeon, Seung-Soon Im
Sterol regulatory element-binding protein (SREBP)-1c is involved in cellular lipid homeostasis and cholesterol biosynthesis and is highly increased in nonalcoholic steatohepatitis (NASH). However, the molecular mechanism by which SREBP-1c regulates hepatic stellate cells (HSCs) activation in NASH animal models and patients have not been fully elucidated. In this study, we examined the role of SREBP-1c in NASH and the regulation of LCN2 gene expression. Wild-type and SREBP-1c knockout (1cKO) mice were fed a high-fat/high-sucrose diet, treated with carbon tetrachloride (CCl4 ), and subjected to lipocalin-2 (LCN2) overexpression...
April 16, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38621951/-evidence-map-of-clinical-research-on-chinese-patent-medicines-for-post-acute-myocardial-infarction-heart-failure
#23
JOURNAL ARTICLE
Chi-Dao Zhang, Jin-Yu Huang, Yong-Xia Wang, Ming-Jun Zhu, Zuo-Ying Xing, Bo-Yong Qiu
An evidence map was established to comprehensively sort out the clinical research in the treatment of post-acute myocardial infarction heart failure(P-AMI-HF) with Chinese patent medicines, so as to reveal the distribution of evidence in this field. CNKI, Wanfang, VIP, SinoMed, PubMed, Cochrane Library, and EMbase were searched for the randomized controlled trial(RCT), systematic reviews/Meta-analysis, and guidelines/consensus in this field. The evidence was analyzed and displayed in the form of a combination of text, charts, bubble charts, and bar charts, and the quality of RCT, systematic reviews/Meta-analysis, and guidelines/consensus were evaluated by RoB 1...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38621375/left-ventricular-strain-arch-angulation-and-velocity-time-integral-ratio-improve-performance-of-a-clinical-pathway-for-fetal-diagnosis-of-neonatal-coarctation-of-the-aorta
#24
JOURNAL ARTICLE
Aaron Anthony Phillips, Rajesh Punn, Claudia Algaze, Yair J Blumenfeld, Valerie Y Chock, David M Kwiatokowski, Amy Quirin, Theresa A Tacy, Kelly Thorson, Shiraz A Maskatia
INTRODUCTION: Neonatal presentation of coarctation of the aorta (CoA) is a potentially life-threatening condition that is difficult to diagnose in fetal life. We therefore sought to validate and compare novel metrics that may add diagnostic value for fetal coarctation of the aorta, including the diastolic to systolic aortic isthmus VTI ratio (VTId:VTIs), ascending aorta to descending aorta angle (AAo-DAo), transverse aorta to descending aorta angle (TAo-DAo), and LV longitudinal strain (LVS)...
April 15, 2024: Fetal Diagnosis and Therapy
https://read.qxmd.com/read/38618215/measurement-of-postoperative-apical-vertebral-rotation-using-radiographic-images-in-adolescent-idiopathic-scoliosis-quantitative-evaluation-using-inverse-trigonometric-functions
#25
JOURNAL ARTICLE
Shun Okuwaki, Toshiaki Kotani, Shuhei Ohyama, Shuhei Iwata, Tsuyoshi Sakuma, Yasushi Iijima, Tsutomu Akazawa, Kazuhide Inage, Yasuhiro Shiga, Shohei Minami, Seiji Ohtori, Masashi Yamazaki
INTRODUCTION: Conventional methods for analyzing vertebral rotation are limited to postoperative patients who underwent posterior fusion. A previous methodology calculated vertebral rotation using inverse trigonometric functions based on the length of the pedicle screw (PS). Accordingly, this study evaluates rotational deformity in patients with postoperative adolescent idiopathic scoliosis (AIS) using inverse trigonometric functions. METHODS: This retrospective single-center study includes patients with AIS who underwent posterior fusion surgery...
March 27, 2024: Spine surgery and related research
https://read.qxmd.com/read/38616167/synthesis-and-antifungal-activity-of-norbornene-carboxamide-sulfonamide-derivatives-as-potential-fungicides-targeting-laccase
#26
JOURNAL ARTICLE
Zi-Hui Yang, Yi-Gui Qiu, Dao-Jun Jin, Yi-Ming Zheng, Jia Li, Wen Gu
To explore more potential fungicides with new scaffolds, thirty-seven norbornene carboxamide/sulfonamide derivatives were designed, synthesized, and assayed for inhibitory activity against six plant pathogenic fungi and oomycetes. The preliminary antifungal assay suggested that the title derivatives showed moderate to good antifungal activity against six plant pathogens. Especially, compound 6e presented excellent in vitro antifungal activity against Sclerotinia sclerotiorum (EC50 = 0.71 mg/L), which was substantially stronger than pydiflumetofen...
April 14, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38613283/study-of-high-transverse-momentum-higgs-boson-production-in-association-with-a-vector-boson-in-the-qqbb-final-state-with-the-atlas-detector
#27
JOURNAL ARTICLE
G Aad, B Abbott, K Abeling, N J Abicht, S H Abidi, A Aboulhorma, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, C Adam Bourdarios, L Adamczyk, S V Addepalli, M J Addison, J Adelman, A Adiguzel, T Adye, A A Affolder, Y Afik, M N Agaras, J Agarwala, A Aggarwal, C Agheorghiesei, A Ahmad, F Ahmadov, W S Ahmed, S Ahuja, X Ai, G Aielli, A Aikot, M Ait Tamlihat, B Aitbenchikh, I Aizenberg, M Akbiyik, T P A Åkesson, A V Akimov, D Akiyama, N N Akolkar, S Aktas, K Al Khoury, G L Alberghi, J Albert, P Albicocco, G L Albouy, S Alderweireldt, Z L Alegria, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, F Alfonsi, M Algren, M Alhroob, B Ali, H M J Ali, S Ali, S W Alibocus, M Aliev, G Alimonti, W Alkakhi, C Allaire, B M M Allbrooke, J F Allen, C A Allendes Flores, P P Allport, A Aloisio, F Alonso, C Alpigiani, M Alvarez Estevez, A Alvarez Fernandez, M Alves Cardoso, M G Alviggi, M Aly, Y Amaral Coutinho, A Ambler, C Amelung, M Amerl, C G Ames, D Amidei, S P Amor Dos Santos, K R Amos, V Ananiev, C Anastopoulos, T Andeen, J K Anders, S Y Andrean, A Andreazza, S Angelidakis, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, E Antipov, M Antonelli, F Anulli, M Aoki, T Aoki, J A Aparisi Pozo, M A Aparo, L Aperio Bella, C Appelt, A Apyan, N Aranzabal, S J Arbiol Val, C Arcangeletti, A T H Arce, E Arena, J-F Arguin, S Argyropoulos, J-H Arling, O Arnaez, H Arnold, G Artoni, H Asada, K Asai, S Asai, N A Asbah, K Assamagan, R Astalos, S Atashi, R J Atkin, M Atkinson, H Atmani, P A Atmasiddha, K Augsten, S Auricchio, A D Auriol, V A Austrup, G Avolio, K Axiotis, G Azuelos, D Babal, H Bachacou, K Bachas, A Bachiu, F Backman, A Badea, T M Baer, P Bagnaia, M Bahmani, D Bahner, A J Bailey, V R Bailey, J T Baines, L Baines, O K Baker, E Bakos, D Bakshi Gupta, V Balakrishnan, R Balasubramanian, E M Baldin, P Balek, E Ballabene, F Balli, L M Baltes, W K Balunas, J Balz, E Banas, M Bandieramonte, A Bandyopadhyay, S Bansal, L Barak, M Barakat, E L Barberio, D Barberis, M Barbero, M Z Barel, K N Barends, T Barillari, M-S Barisits, T Barklow, P Baron, D A Baron Moreno, A Baroncelli, G Barone, A J Barr, J D Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, U Barron, M G Barros Teixeira, S Barsov, F Bartels, R Bartoldus, A E Barton, P Bartos, A Basan, M Baselga, A Bassalat, M J Basso, C R Basson, R L Bates, S Batlamous, J R Batley, B Batool, M Battaglia, D Battulga, M Bauce, M Bauer, P Bauer, L T Bazzano Hurrell, J B Beacham, T Beau, J Y Beaucamp, P H Beauchemin, P Bechtle, H P Beck, K Becker, A J Beddall, V A Bednyakov, C P Bee, L J Beemster, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, J F Beirer, F Beisiegel, M Belfkir, G Bella, L Bellagamba, A Bellerive, P Bellos, K Beloborodov, D Benchekroun, F Bendebba, Y Benhammou, M Benoit, S Bentvelsen, L Beresford, M Beretta, E Bergeaas Kuutmann, N Berger, B Bergmann, J Beringer, G Bernardi, C Bernius, F U Bernlochner, F Bernon, A Berrocal Guardia, T Berry, P Berta, A Berthold, I A Bertram, S Bethke, A Betti, A J Bevan, N K Bhalla, M Bhamjee, S Bhatta, D S Bhattacharya, P Bhattarai, V S Bhopatkar, R Bi, R M Bianchi, G Bianco, O Biebel, R Bielski, M Biglietti, M Bindi, A Bingul, C Bini, A Biondini, C J Birch-Sykes, G A Bird, M Birman, M Biros, S Biryukov, T Bisanz, E Bisceglie, J P Biswal, D Biswas, A Bitadze, K Bjørke, I Bloch, A Blue, U Blumenschein, J Blumenthal, G J Bobbink, V S Bobrovnikov, M Boehler, B Boehm, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, M Bomben, M Bona, M Boonekamp, C D Booth, A G Borbély, I S Bordulev, H M Borecka-Bielska, G Borissov, D Bortoletto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, N Bouchhar, J Boudreau, E V Bouhova-Thacker, D Boumediene, R Bouquet, A Boveia, J Boyd, D Boye, I R Boyko, J Bracinik, N Brahimi, G Brandt, O Brandt, F Braren, B Brau, J E Brau, R Brener, L Brenner, R Brenner, S Bressler, D Britton, D Britzger, I Brock, G Brooijmans, W K Brooks, E Brost, L M Brown, L E Bruce, T L Bruckler, P A Bruckman de Renstrom, B Brüers, A Bruni, G Bruni, M Bruschi, N Bruscino, T Buanes, Q Buat, D Buchin, A G Buckley, O Bulekov, B A Bullard, S Burdin, C D Burgard, A M Burger, B Burghgrave, O Burlayenko, J T P Burr, C D Burton, J C Burzynski, E L Busch, V Büscher, P J Bussey, J M Butler, C M Buttar, J M Butterworth, W Buttinger, C J Buxo Vazquez, A R Buzykaev, S Cabrera Urbán, L Cadamuro, D Caforio, H Cai, Y Cai, Y Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, G Calderini, P Calfayan, G Callea, L P Caloba, D Calvet, S Calvet, M Calvetti, R Camacho Toro, S Camarda, D Camarero Munoz, P Camarri, M T Camerlingo, D Cameron, C Camincher, M Campanelli, A Camplani, V Canale, A Canesse, J Cantero, Y Cao, F Capocasa, M Capua, A Carbone, R Cardarelli, J C J Cardenas, F Cardillo, G Carducci, T Carli, G Carlino, J I Carlotto, B T Carlson, E M Carlson, L Carminati, A Carnelli, M Carnesale, S Caron, E Carquin, S Carrá, G Carratta, F Carrio Argos, J W S Carter, T M Carter, M P Casado, M Caspar, F L Castillo, L Castillo Garcia, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, V Cavaliere, N Cavalli, V Cavasinni, Y C Cekmecelioglu, E Celebi, F Celli, M S Centonze, V Cepaitis, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, B Cervato, A Cervelli, G Cesarini, S A Cetin, D Chakraborty, J Chan, W Y Chan, J D Chapman, E Chapon, B Chargeishvili, D G Charlton, M Chatterjee, C Chauhan, S Chekanov, S V Chekulaev, G A Chelkov, A Chen, B Chen, B Chen, H Chen, H Chen, J Chen, J Chen, M Chen, S Chen, S J Chen, X Chen, X Chen, Y Chen, C L Cheng, H C Cheng, S Cheong, A Cheplakov, E Cheremushkina, E Cherepanova, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, N Chiedde, G Chiodini, A S Chisholm, A Chitan, M Chitishvili, M V Chizhov, K Choi, A R Chomont, Y Chou, E Y S Chow, T Chowdhury, K L Chu, M C Chu, X Chu, J Chudoba, J J Chwastowski, D Cieri, K M Ciesla, V Cindro, A Ciocio, F Cirotto, Z H Citron, M Citterio, D A Ciubotaru, A Clark, P J Clark, C Clarry, J M Clavijo Columbie, S E Clawson, C Clement, J Clercx, Y Coadou, M Cobal, A Coccaro, R F Coelho Barrue, R Coelho Lopes De Sa, S Coelli, A E C Coimbra, B Cole, J Collot, P Conde Muiño, M P Connell, S H Connell, I A Connelly, E I Conroy, F Conventi, H G Cooke, A M Cooper-Sarkar, A Cordeiro Oudot Choi, L D Corpe, M Corradi, F Corriveau, A Cortes-Gonzalez, M J Costa, F Costanza, D Costanzo, B M Cote, G Cowan, K Cranmer, D Cremonini, S Crépé-Renaudin, F Crescioli, M Cristinziani, M Cristoforetti, V Croft, J E Crosby, G Crosetti, A Cueto, T Cuhadar Donszelmann, H Cui, Z Cui, W R Cunningham, F Curcio, P Czodrowski, M M Czurylo, M J Da Cunha Sargedas De Sousa, J V Da Fonseca Pinto, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, D Dal Santo, C Dallapiccola, M Dam, G D'amen, V D'Amico, J Damp, J R Dandoy, M Danninger, V Dao, G Darbo, S Darmora, S J Das, S D'Auria, C David, T Davidek, B Davis-Purcell, I Dawson, H A Day-Hall, K De, R De Asmundis, N De Biase, S De Castro, N De Groot, P de Jong, H De la Torre, A De Maria, A De Salvo, U De Sanctis, F De Santis, A De Santo, J B De Vivie De Regie, D V Dedovich, J Degens, A M Deiana, F Del Corso, J Del Peso, F Del Rio, L Delagrange, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, P A Delsart, S Demers, M Demichev, S P Denisov, L D'Eramo, D Derendarz, F Derue, P Dervan, K Desch, C Deutsch, F A Di Bello, A Di Ciaccio, L Di Ciaccio, A Di Domenico, C Di Donato, A Di Girolamo, G Di Gregorio, A Di Luca, B Di Micco, R Di Nardo, C Diaconu, M Diamantopoulou, F A Dias, T Dias Do Vale, M A Diaz, F G Diaz Capriles, M Didenko, E B Diehl, L Diehl, S Díez Cornell, C Diez Pardos, C Dimitriadi, A Dimitrievska, J Dingfelder, I-M Dinu, S J Dittmeier, F Dittus, F Djama, T Djobava, C Doglioni, A Dohnalova, J Dolejsi, Z Dolezal, K M Dona, M Donadelli, B Dong, J Donini, A D'Onofrio, M D'Onofrio, J Dopke, A Doria, N Dos Santos Fernandes, P Dougan, M T Dova, A T Doyle, M A Draguet, E Dreyer, I Drivas-Koulouris, M Drnevich, A S Drobac, M Drozdova, D Du, T A du Pree, F Dubinin, M Dubovsky, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, E R Duden, M D'uffizi, L Duflot, M Dührssen, A E Dumitriu, M Dunford, S Dungs, K Dunne, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, B L Dwyer, G I Dyckes, M Dyndal, B S Dziedzic, Z O Earnshaw, G H Eberwein, B Eckerova, S Eggebrecht, E Egidio Purcino De Souza, L F Ehrke, G Eigen, K Einsweiler, T Ekelof, P A Ekman, S El Farkh, Y El Ghazali, H El Jarrari, A El Moussaouy, V Ellajosyula, M Ellert, F Ellinghaus, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, I Ene, S Epari, P A Erland, M Errenst, M Escalier, C Escobar, E Etzion, G Evans, H Evans, L S Evans, M O Evans, A Ezhilov, S Ezzarqtouni, F Fabbri, L Fabbri, G Facini, V Fadeyev, R M Fakhrutdinov, D Fakoudis, S Falciano, L F Falda Ulhoa Coelho, P J Falke, J Faltova, C Fan, Y Fan, Y Fang, M Fanti, M Faraj, Z Farazpay, A Farbin, A Farilla, T Farooque, S M Farrington, F Fassi, D Fassouliotis, M Faucci Giannelli, W J Fawcett, L Fayard, P Federic, P Federicova, O L Fedin, G Fedotov, M Feickert, L Feligioni, D E Fellers, C Feng, M Feng, Z Feng, M J Fenton, A B Fenyuk, L Ferencz, R A M Ferguson, S I Fernandez Luengo, P Fernandez Martinez, M J V Fernoux, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D Ferrere, C Ferretti, F Fiedler, P Fiedler, A Filipčič, E K Filmer, F Filthaut, M C N Fiolhais, L Fiorini, W C Fisher, T Fitschen, P M Fitzhugh, I Fleck, P Fleischmann, T Flick, M Flores, L R Flores Castillo, L Flores Sanz De Acedo, F M Follega, N Fomin, J H Foo, A Formica, A C Forti, E Fortin, A W Fortman, M G Foti, L Fountas, D Fournier, H Fox, P Francavilla, S Francescato, S Franchellucci, M Franchini, S Franchino, D Francis, L Franco, V Franco Lima, L Franconi, M Franklin, G Frattari, A C Freegard, W S Freund, Y Y Frid, J Friend, N Fritzsche, A Froch, D Froidevaux, J A Frost, Y Fu, S Fuenzalida Garrido, M Fujimoto, K Y Fung, E Furtado De Simas Filho, M Furukawa, J Fuster, A Gabrielli, A Gabrielli, P Gadow, G Gagliardi, L G Gagnon, E J Gallas, B J Gallop, K K Gan, S Ganguly, Y Gao, F M Garay Walls, B Garcia, C García, A Garcia Alonso, A G Garcia Caffaro, J E García Navarro, M Garcia-Sciveres, G L Gardner, R W Gardner, N Garelli, D Garg, R B Garg, J M Gargan, C A Garner, C M Garvey, P Gaspar, V K Gassmann, G Gaudio, V Gautam, P Gauzzi, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, A A Geanta, C M Gee, A Gekow, C Gemme, M H Genest, S Gentile, A D Gentry, S George, W F George, T Geralis, P Gessinger-Befurt, M E Geyik, M Ghani, M Ghneimat, K Ghorbanian, A Ghosal, A Ghosh, A Ghosh, B Giacobbe, S Giagu, T Giani, P Giannetti, A Giannini, S M Gibson, M Gignac, D T Gil, A K Gilbert, B J Gilbert, D Gillberg, G Gilles, N E K Gillwald, L Ginabat, D M Gingrich, M P Giordani, P F Giraud, G Giugliarelli, D Giugni, F Giuli, I Gkialas, L K Gladilin, C Glasman, G R Gledhill, G Glemža, M Glisic, I Gnesi, Y Go, M Goblirsch-Kolb, B Gocke, D Godin, B Gokturk, S Goldfarb, T Golling, M G D Gololo, D Golubkov, J P Gombas, A Gomes, G Gomes Da Silva, A J Gomez Delegido, R Gonçalo, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, R Y González Andana, S González de la Hoz, R Gonzalez Lopez, C Gonzalez Renteria, M V Gonzalez Rodrigues, R Gonzalez Suarez, S Gonzalez-Sevilla, G R Gonzalvo Rodriguez, L Goossens, B Gorini, E Gorini, A Gorišek, T C Gosart, A T Goshaw, M I Gostkin, S Goswami, C A Gottardo, S A Gotz, M Gouighri, V Goumarre, A G Goussiou, N Govender, I Grabowska-Bold, K Graham, E Gramstad, S Grancagnolo, M Grandi, C M Grant, P M Gravila, F G Gravili, H M Gray, M Greco, C Grefe, I M Gregor, P Grenier, S G Grewe, C Grieco, A A Grillo, K Grimm, S Grinstein, J-F Grivaz, E Gross, J Grosse-Knetter, C Grud, J C Grundy, L Guan, W Guan, C Gubbels, J G R Guerrero Rojas, G Guerrieri, F Guescini, R Gugel, J A M Guhit, A Guida, E Guilloton, S Guindon, F Guo, J Guo, L Guo, Y Guo, R Gupta, R Gupta, S Gurbuz, S S Gurdasani, G Gustavino, M Guth, P Gutierrez, L F Gutierrez Zagazeta, M Gutsche, C Gutschow, C Gwenlan, C B Gwilliam, E S Haaland, A Haas, M Habedank, C Haber, H K Hadavand, A Hadef, S Hadzic, A I Hagan, J J Hahn, E H Haines, M Haleem, J Haley, J J Hall, G D Hallewell, L Halser, K Hamano, M Hamer, G N Hamity, E J Hampshire, J Han, K Han, L Han, L Han, S Han, Y F Han, K Hanagaki, M Hance, D A Hangal, H Hanif, M D Hank, J B Hansen, P H Hansen, K Hara, D Harada, T Harenberg, S Harkusha, M L Harris, Y T Harris, J Harrison, N M Harrison, P F Harrison, N M Hartman, N M Hartmann, Y Hasegawa, R Hauser, C M Hawkes, R J Hawkings, Y Hayashi, S Hayashida, D Hayden, C Hayes, R L Hayes, C P Hays, J M Hays, H S Hayward, F He, M He, Y He, Y He, N B Heatley, V Hedberg, A L Heggelund, N D Hehir, C Heidegger, K K Heidegger, W D Heidorn, J Heilman, S Heim, T Heim, J G Heinlein, J J Heinrich, L Heinrich, J Hejbal, L Helary, A Held, S Hellesund, C M Helling, S Hellman, R C W Henderson, L Henkelmann, A M Henriques Correia, H Herde, Y Hernández Jiménez, L M Herrmann, T Herrmann, G Herten, R Hertenberger, L Hervas, M E Hesping, N P Hessey, H Hibi, E Hill, S J Hillier, J R Hinds, F Hinterkeuser, M Hirose, S Hirose, D Hirschbuehl, T G Hitchings, B Hiti, J Hobbs, R Hobincu, N Hod, M C Hodgkinson, B H Hodkinson, A Hoecker, D D Hofer, J Hofer, T Holm, M Holzbock, L B A H Hommels, B P Honan, J Hong, T M Hong, B H Hooberman, W H Hopkins, Y Horii, S Hou, A S Howard, J Howarth, J Hoya, M Hrabovsky, A Hrynevich, T Hryn'ova, P J Hsu, S-C Hsu, Q Hu, Y F Hu, S Huang, X Huang, X Huang, Y Huang, Y Huang, Z Huang, Z Hubacek, M Huebner, F Huegging, T B Huffman, C A Hugli, M Huhtinen, S K Huiberts, R Hulsken, N Huseynov, J Huston, J Huth, R Hyneman, G Iacobucci, G Iakovidis, I Ibragimov, L Iconomidou-Fayard, J P Iddon, P Iengo, R Iguchi, T Iizawa, Y Ikegami, N Ilic, H Imam, M Ince Lezki, T Ingebretsen Carlson, G Introzzi, M Iodice, V Ippolito, R K Irwin, M Ishino, W Islam, C Issever, S Istin, H Ito, J M Iturbe Ponce, R Iuppa, A 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Stelzer-Chilton, H Stenzel, T J Stevenson, G A Stewart, J R Stewart, M C Stockton, G Stoicea, M Stolarski, S Stonjek, A Straessner, J Strandberg, S Strandberg, M Stratmann, M Strauss, T Strebler, P Strizenec, R Ströhmer, D M Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, J Stupak, N A Styles, D Su, S Su, W Su, X Su, K Sugizaki, V V Sulin, M J Sullivan, D M S Sultan, L Sultanaliyeva, S Sultansoy, T Sumida, S Sun, S Sun, O Sunneborn Gudnadottir, N Sur, M R Sutton, H Suzuki, M Svatos, M Swiatlowski, T Swirski, I Sykora, M Sykora, T Sykora, D Ta, K Tackmann, A Taffard, R Tafirout, J S Tafoya Vargas, E P Takeva, Y Takubo, M Talby, A A Talyshev, K C Tam, N M Tamir, A Tanaka, J Tanaka, R Tanaka, M Tanasini, Z Tao, S Tapia Araya, S Tapprogge, A Tarek Abouelfadl Mohamed, S Tarem, K Tariq, G Tarna, G F Tartarelli, P Tas, M Tasevsky, E Tassi, A C Tate, G Tateno, Y Tayalati, G N Taylor, W Taylor, A S Tee, R Teixeira De Lima, P Teixeira-Dias, J J Teoh, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, A Thaler, O Theiner, N Themistokleous, T Theveneaux-Pelzer, O Thielmann, D W Thomas, J P Thomas, E A Thompson, P D Thompson, E Thomson, Y Tian, V Tikhomirov, Yu A Tikhonov, S Timoshenko, D Timoshyn, E X L Ting, P Tipton, S H Tlou, A Tnourji, K Todome, S Todorova-Nova, S Todt, M Togawa, J Tojo, S Tokár, K Tokushuku, O Toldaiev, R Tombs, M Tomoto, L Tompkins, K W Topolnicki, E Torrence, H Torres, E Torró Pastor, M Toscani, C Tosciri, M Tost, D R Tovey, A Traeet, I S Trandafir, T Trefzger, A Tricoli, I M Trigger, S Trincaz-Duvoid, D A Trischuk, B Trocmé, C Troncon, L Truong, M Trzebinski, A Trzupek, F Tsai, M Tsai, A Tsiamis, P V Tsiareshka, S Tsigaridas, A Tsirigotis, V Tsiskaridze, E G Tskhadadze, M Tsopoulou, Y Tsujikawa, I I Tsukerman, V Tsulaia, S Tsuno, K Tsuri, D Tsybychev, Y Tu, A Tudorache, V Tudorache, A N Tuna, S Turchikhin, I Turk Cakir, R Turra, T Turtuvshin, P M Tuts, S Tzamarias, P Tzanis, E Tzovara, F Ukegawa, P A Ulloa Poblete, E N Umaka, G Unal, M Unal, A Undrus, G Unel, J Urban, P Urquijo, P Urrejola, G Usai, R Ushioda, M Usman, Z Uysal, V Vacek, B Vachon, K O H Vadla, T Vafeiadis, A Vaitkus, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, E Valiente Moreno, A Vallier, J A Valls Ferrer, D R Van Arneman, T R Van Daalen, A Van Der Graaf, P Van Gemmeren, M Van Rijnbach, S Van Stroud, I Van Vulpen, M Vanadia, W Vandelli, M Vandenbroucke, E R Vandewall, D Vannicola, L Vannoli, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, L Varriale, K E Varvell, M E Vasile, L Vaslin, G A Vasquez, A Vasyukov, F Vazeille, T Vazquez Schroeder, J Veatch, V Vecchio, M J Veen, I Veliscek, L M Veloce, F Veloso, S Veneziano, A Ventura, S Ventura Gonzalez, A Verbytskyi, M Verducci, C Vergis, M Verissimo De Araujo, W Verkerke, J C Vermeulen, C Vernieri, M Vessella, M C Vetterli, A Vgenopoulos, N Viaux Maira, T Vickey, O E Vickey Boeriu, G H A Viehhauser, L Vigani, M Villa, M Villaplana Perez, E M Villhauer, E Vilucchi, M G Vincter, G S Virdee, A Vishwakarma, A Visibile, C Vittori, I Vivarelli, E Voevodina, F Vogel, J C Voigt, P Vokac, Yu Volkotrub, J Von Ahnen, E Von Toerne, B Vormwald, V Vorobel, K Vorobev, M Vos, K Voss, J H Vossebeld, M Vozak, L Vozdecky, N Vranjes, M Vranjes Milosavljevic, M Vreeswijk, N K Vu, R Vuillermet, O Vujinovic, I Vukotic, S Wada, C Wagner, J M Wagner, W Wagner, S Wahdan, H Wahlberg, M Wakida, J Walder, R Walker, W Walkowiak, A Wall, T Wamorkar, A Z Wang, C Wang, C Wang, H Wang, J Wang, R-J Wang, R Wang, R Wang, S M Wang, S Wang, T Wang, W T Wang, W Wang, X Wang, X Wang, X Wang, Y Wang, Y Wang, Z Wang, Z Wang, Z Wang, A Warburton, R J Ward, N Warrack, S Waterhouse, A T Watson, H Watson, M F Watson, E Watton, G Watts, B M Waugh, C Weber, H A Weber, M S Weber, S M Weber, C Wei, Y Wei, A R Weidberg, E J Weik, J Weingarten, M Weirich, C Weiser, C J Wells, T Wenaus, B Wendland, T Wengler, N S Wenke, N Wermes, M Wessels, A M Wharton, A S White, A White, M J White, D Whiteson, L Wickremasinghe, W Wiedenmann, M Wielers, C Wiglesworth, D J Wilbern, H G Wilkens, D M Williams, H H Williams, S Williams, S Willocq, B J Wilson, P J Windischhofer, F I Winkel, F Winklmeier, B T Winter, J K Winter, M Wittgen, M Wobisch, Z Wolffs, J Wollrath, M W Wolter, H Wolters, A F Wongel, E L Woodward, S D Worm, B K Wosiek, K W Woźniak, S Wozniewski, K Wraight, C Wu, J Wu, M Wu, M Wu, S L Wu, X Wu, Y Wu, Z Wu, J Wuerzinger, T R Wyatt, B M Wynne, S Xella, L Xia, M Xia, J Xiang, M Xie, X Xie, S Xin, A Xiong, J Xiong, D Xu, H Xu, L Xu, R Xu, T Xu, Y Xu, Z Xu, Z Xu, B Yabsley, S Yacoob, Y Yamaguchi, E Yamashita, H Yamauchi, T Yamazaki, Y Yamazaki, J Yan, S Yan, Z Yan, H J Yang, H T Yang, S Yang, T Yang, X Yang, X Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, H Ye, H Ye, J Ye, S Ye, X Ye, Y Yeh, I Yeletskikh, B K Yeo, M R Yexley, P Yin, K Yorita, S Younas, C J S Young, C Young, C Yu, Y Yu, M Yuan, R Yuan, L Yue, M Zaazoua, B Zabinski, E Zaid, Z K Zak, T Zakareishvili, N Zakharchuk, S Zambito, J A Zamora Saa, J Zang, D Zanzi, O Zaplatilek, C Zeitnitz, H Zeng, J C Zeng, D T Zenger, O Zenin, T Ženiš, S Zenz, S Zerradi, D Zerwas, M Zhai, B Zhang, D F Zhang, J Zhang, J Zhang, K Zhang, L Zhang, P Zhang, R Zhang, S Zhang, S Zhang, T Zhang, X Zhang, X Zhang, Y Zhang, Y Zhang, Y Zhang, Z Zhang, Z Zhang, H Zhao, T Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zheng, K Zheng, X Zheng, Z Zheng, D Zhong, B Zhou, H Zhou, N Zhou, Y Zhou, Y Zhou, C G Zhu, J Zhu, Y Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, N I Zimine, J Zinsser, M Ziolkowski, L Živković, A Zoccoli, K Zoch, T G Zorbas, O Zormpa, W Zou, L Zwalinski
This Letter presents the first study of Higgs boson production in association with a vector boson (V=W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in proton-proton collisions at sqrt[s]=13  TeV and corresponding to an integrated luminosity of 137  fb^{-1}. The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into bb[over ¯]...
March 29, 2024: Physical Review Letters
https://read.qxmd.com/read/38612963/development-and-feasibility-of-an-ehealth-diabetes-prevention-program-adapted-for-older-adults-results-from-a-randomized-control-pilot-study
#28
JOURNAL ARTICLE
Suzannah Gerber, Rachel E Silver, Sai Krupa Das, Savana S Greene, Sadie R Dix, Isabella Ramirez, Christina L Morcos, Maria Carlota Dao, Lisa Ceglia, Susan B Roberts
Lifestyle programs that reduce health risks and support weight loss (WL) in older adults face adherence and attendance challenges due to reduced energy requirements, impaired mobility, lack of transportation, and low social support. Tailored lifestyle and weight management programs are needed to better support healthy aging for older adults. Here, we developed and piloted an age-adapted, remotely delivered modification of the Diabetes Prevention Program (DPP). The modification includes age-appropriate goals, visuals, and examples; flexible dietary composition; remote classroom and fitness-monitoring technology; and standardized online classroom materials employing pedagogical and behavior change theory...
March 23, 2024: Nutrients
https://read.qxmd.com/read/38612774/physiological-metabolic-and-transcriptomic-analyses-reveal-mechanisms-of-proliferation-and-somatic-embryogenesis-of-litchi-litchi-chinensis-sonn-embryogenic-callus-promoted-by-d-arginine-treatment
#29
JOURNAL ARTICLE
Ludan Cao, Guo Wang, Xiuxu Ye, Fang Li, Shujun Wang, Huanling Li, Peng Wang, Jiabao Wang
D-arginine (D-Arg) can promote embryogenic callus (EC) proliferation and increase the rate of somatic embryo induction of litchi ( Litchi chinensis Sonn.), yet the mechanism underlying the processes is incompletely understood. To investigate the mechanism, physiological responses of polyamines (PAs) [putrescine (Put), spermidine (Spd), and spermine (Spm)] were investigated for D-Arg-treated litchi EC and enzyme activity related to polyamine metabolism, plant endogenous hormones, and polyamine- and embryogenic-related genes were explored...
April 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38610655/approach-to-liver-transplantation-is-there-a-difference-between-east-and-west
#30
REVIEW
Nazli Begum Ozturk, Nathanial Bartosek, Merih Deniz Toruner, Aymen Mumtaz, Cem Simsek, Doan Dao, Behnam Saberi, Ahmet Gurakar
Liver transplantation (LT) remains the only curative treatment for end-stage liver disease as well as acute liver failure. With the exponential increase in organ demand due to the increasing incidence and prevalence of liver diseases, the need to overcome the supply and demand mismatch has arisen. In this review, we discuss the current universal status of LT, emphasizing various LT practices worldwide.
March 25, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38608859/loss-of-the-histone-chaperone-unc-85-asf1-inhibits-the-epigenome-mediated-longevity-and-modulates-the-activity-of-one-carbon-metabolism
#31
JOURNAL ARTICLE
Bideep Shrestha, Anni I Nieminen, Olli Matilainen
Histone H3/H4 chaperone ASF1 is a conserved factor mediating nucleosomal assembly and disassembly, playing crucial roles in processes such as replication, transcription, and DNA repair. Nevertheless, its involvement in aging has remained unclear. Here, we utilized the model organism Caenorhabditis elegans to demonstrate that the loss of UNC-85, the homolog of ASF1, leads to a shortened lifespan in a multicellular organism. Furthermore, we show that UNC-85 is required for epigenome-mediated longevity, as knockdown of the H3K4 methyltransferase ash-2 does not extend the lifespan of unc-85 mutants...
April 10, 2024: Cell Stress & Chaperones
https://read.qxmd.com/read/38606411/markers-of-intestinal-barrier-damage-in-patients-with-chronic-insomnia-disorder
#32
JOURNAL ARTICLE
Yixian Cai, Di Gong, Ting Xiang, Xiaotao Zhang, Jiyang Pan
OBJECTIVE: Insomnia disorder stands out as one of the prevalent clinical sleep and psychiatric disorders. Prior research has unequivocally demonstrated variations in the diversity and abundance of gut microbiota among individuals with insomnia disorder. These alterations may play a direct or indirect role in the onset and progression of insomnia disorder by compromising the integrity of the intestinal barrier. This study aims to evaluate the impairment of the intestinal barrier in individuals with insomnia disorder by scrutinizing the serum functionality of this barrier...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38606018/dietary-vitamin-a-modifies-the-gut-microbiota-and-intestinal-tissue-transcriptome-impacting-intestinal-permeability-and-the-release-of-inflammatory-factors-thereby-influencing-a%C3%AE-pathology
#33
JOURNAL ARTICLE
Zhong-Li Wang, Shao-Jie Pang, Kai-Wen Zhang, Peng-Yu Li, Peng-Gao Li, Chun Yang
BACKGROUND: Alzheimer's disease (AD) is an age-related neurodegenerative disorder with no effective interventions for curing or modifying its progression. However, emerging research suggests that vitamin A in the diet may play a role in both the prevention and treatment of AD, although the exact mechanisms are not fully understood. OBJECTIVES: This study aims to investigate the dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, thereby influencing Aβ pathology shedding light on its potential as a dietary intervention for AD prevention and treatment...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38605818/a-framework-of-computer-vision-enhanced-microfluidic-approach-for-automated-assessment-of-the-transient-sickling-kinetics-in-sickle-red-blood-cells
#34
JOURNAL ARTICLE
Yuhao Qiang, Mengjia Xu, Mira Patel Pochron, Madhulika Jupelli, Ming Dao
The occurrence of vaso-occlusive crisis greatly depends on the competition between the sickling delay time and the transit time of individual sickle cells, i.e., red blood cells (RBCs) from sickle cell disease (SCD) patients, while they are traversing the circulatory system. Many drugs for treating SCD work by inhibiting the polymerization of sickle hemoglobin (HbS), effectively delaying the sickling process in sickle cells (SS RBCs). Most previous studies on screening anti-sickling drugs, such as voxelotor, rely on in vitro testing of sickling characteristics, often conducted under prolonged deoxygenation for up to 1 hour...
2024: Frontiers in Physics
https://read.qxmd.com/read/38605459/simultaneous-quantitation-of-15-bioactive-components-in-yupingfeng-granules-by-lc-ms-ms
#35
JOURNAL ARTICLE
Le-Yi Huang, Dao-Feng Chen, Tong Wu, Yong-Jian Gao
Yupingfeng granules (YPFG) is commonly used in the treatment of immunological diseases, inflammations, and pulmonary diseases. Several studies have found that chromones, flavones, and saponins were the major bioactive compounds of YPFG. However, few studies have reported accurate quantification methods of these compounds. This study aimed to establish a simple and rapid method by using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to determine 15 bioactive compounds in YPFG. The experimental parameters including extraction methods, extraction solvents, extraction time, solid-liquid ratio, and LC-MS/MS condition were optimized...
May 2024: Journal of Mass Spectrometry: JMS
https://read.qxmd.com/read/38604519/enrofloxacin-exposure-undermines-gut-health-and-disrupts-neurotransmitters-along-the-microbiota-gut-brain-axis-in-zebrafish
#36
JOURNAL ARTICLE
Dandan Tian, Weixia Zhang, Lingzheng Lu, Yihan Yu, Yingying Yu, Xunyi Zhang, Weifeng Li, Wei Shi, Guangxu Liu
The environmental prevalence of antibiotic residues poses a potential threat to gut health and may thereby disrupt brain function through the microbiota-gut-brain axis. However, little is currently known about the impacts of antibiotics on gut health and neurotransmitters along the microbiota-gut-brain axis in fish species. Taking enrofloxacin (ENR) as a representative, the impacts of antibiotic exposure on the gut structural integrity, intestinal microenvironment, and neurotransmitters along the microbiota-gut-brain axis were evaluated in zebrafish in this study...
April 9, 2024: Chemosphere
https://read.qxmd.com/read/38604009/novel-hybrid-rigid-deformable-fetal-modeling-for-simulating-the-vaginal-delivery-within-the-second-stage-of-labor
#37
JOURNAL ARTICLE
Abbass Ballit, Morgane Ferrandini, Tien-Tuan Dao
BACKGROUND AND OBJECTIVE: The fetal representation as a 3D articulated body plays an essential role to describe a realistic vaginal delivery simulation. However, the current computational solutions have been oversimplified. The objective of the present work was to develop and evaluate a novel hybrid rigid-deformable modeling approach for the fetal body and then simulate its interaction with surrounding fetal soft tissues and with other maternal pelvis soft tissues during the second stage of labor...
April 8, 2024: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/38602315/enantioselective-formal-1-2-diamination-of-ketenes-with-iminosulfinamides-asymmetric-synthesis-of-unnatural-%C3%AE-%C3%AE-disubstituted-%C3%AE-amino-acid-derivatives
#38
JOURNAL ARTICLE
Teng-Fei Liu, Yun Yao, Chong-Dao Lu
A method was developed for the enantioselective formal 1,2-diamination of disubstituted ketenes using iminosulfinamides as nitrogen sources. The protocol involves the addition of lithium iminosulfinamides to ketenes to form N -iminosulfinyl amide metalloenolates. These metalloenolates then undergo a [2,3]-sigmatropic rearrangement to yield unnatural α,α-disubstituted α-amino acid derivatives with high enantiopurity. The chirality present at the sulfur atom in the iminosulfinamides is effectively transferred to α carbon of the resulting products, facilitating the highly enantioselective amination of ketenes...
April 11, 2024: Organic Letters
https://read.qxmd.com/read/38601783/cu-promoted-the-dynamic-evolution-of-ni-based-catalysts-for-polyethylene-terephthalate-plastic-upcycling
#39
JOURNAL ARTICLE
Hongxing Kang, Dong He, Xingxu Yan, Benjamin Dao, Nicholas B Williams, Gregory I Elliott, Daniel Streater, James Nyakuchena, Jier Huang, Xiaoqing Pan, Xiangheng Xiao, Jing Gu
Upcycling plastic wastes into value-added chemicals is a promising approach to put end-of-life plastic wastes back into their ecocycle. As one of the polyesters that is used daily, polyethylene terephthalate (PET) plastic waste is employed here as the model substrate. Herein, a nickel (Ni)-based catalyst was prepared via electrochemically depositing copper (Cu) species on Ni foam (NiCu/NF). The NiCu/NF formed Cu/CuO and Ni/NiO/Ni(OH)2 core-shell structures before electrolysis and reconstructed into NiOOH and CuOOH/Cu(OH)2 active species during the ethylene glycol (EG) oxidation...
April 5, 2024: ACS Catalysis
https://read.qxmd.com/read/38600840/morusacerane-a-new-gammacerane-triterpenoid-from-the-trunk-of-morus-alba-linn-with-%C3%AE-glucosidase-inhibitory-activity
#40
JOURNAL ARTICLE
Hoang-Vinh-Truong Phan, Duy Vu Nguyen, Thi-Kim-Dung Le, Thi-Anh-Minh Nguyen, Phan-Si-Nguyen Dong, Thanh-Nha Tran, Ngoc-Van-Trang Dao, Hieu Cuong Nguyen, Hong Truong Luu, Warinthorn Chavasiri, Le-Thuy-Thuy-Trang Hoang, Van-Kieu Nguyen
This phytochemistry investigation on the trunk of Morus alba L. resulted in the isolation of three triterpenoids, including a new gammacerane triterpenoid - morusacerane ( 1 ); along with two known compounds of betulinic acid ( 2 ) and ursolic acid ( 3 ). The structure elucidation was thoroughly conducted based on 1D, 2D-NMR and HRESIMS spectra, followed by a comparison with existing literatures. The evaluation on α -glucosidase inhibitory exhibited the great potential of the application of these isolated compounds in diabetes treatments...
April 11, 2024: Natural Product Research
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