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https://www.readbyqxmd.com/read/29050985/bromodomain-protein-brd4-promotes-cell-proliferation-in-skin-squamous-cell-carcinoma
#1
Tie Xiang, Jin-Yu Bai, Cang She, Dao-Jiang Yu, Xiao-Zhong Zhou, Tian-Lan Zhao
The present study examined the expression and biological functions of bromodomain-containing protein 4 (BRD4) in skin squamous cell carcinoma (SCC) cells. Our results show that BRD4 mRNA and protein expression was upregulated in human skin SCC cells, as compared to its level in the normal skin keratinocytes and fibroblasts. Treatment with BRD4 inhibitors, JQ1 and CPI203, resulted in proliferation inhibition, apoptosis and cell cycle arrest in both established (A431 cell line) and primary skin SCC cells. Furthermore, BRD4 knockdown (by targeted shRNAs) or knockout (by CRISPR/Cas9) largely inhibited A431 cell proliferation...
October 16, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29049291/a-deep-convolutional-neural-network-for-classification-of-red-blood-cells-in-sickle-cell-anemia
#2
Mengjia Xu, Dimitrios P Papageorgiou, Sabia Z Abidi, Ming Dao, Hong Zhao, George Em Karniadakis
Sickle cell disease (SCD) is a hematological disorder leading to blood vessel occlusion accompanied by painful episodes and even death. Red blood cells (RBCs) of SCD patients have diverse shapes that reveal important biomechanical and bio-rheological characteristics, e.g. their density, fragility, adhesive properties, etc. Hence, having an objective and effective way of RBC shape quantification and classification will lead to better insights and eventual better prognosis of the disease. To this end, we have developed an automated, high-throughput, ex-vivo RBC shape classification framework that consists of three stages...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29046508/the-marcks-protein-amount-is-differently-regulated-by-calpain-during-toxic-effects-of-methylmercury-between-sh-sy5y-and-ea-hy926-cells
#3
Cuong Van Dao, Mitsuya Shiraishi, Atsushi Miyamoto
Methylmercury (MeHg) is an environmental pollutant that shows severe toxicity to humans and animals. However, the molecular mechanisms mediating MeHg toxicity are not completely understood. We have previously reported that the MARCKS protein is involved in the MeHg toxicity to SH-SY5Y neuroblastoma and EA.hy926 vascular endothelial cell lines. In addition, calpain, a Ca(2+)-dependent protease, is suggested to be associated with the MeHg toxicity. Because MARCKS is known as a substrate of calpain, we studied the relation between calpain activation and cleavage of MARCKS and its role in MeHg toxicity...
October 18, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29046435/long-acting-mic-1-gdf15-molecules-to-treat-obesity-evidence-from-mice-to-monkeys
#4
Yumei Xiong, Kenneth Walker, Xiaoshan Min, Clarence Hale, Thanhvien Tran, Renee Komorowski, Jerry Yang, Jasmine Davda, Noi Nuanmanee, Dao Kemp, Xiaozhen Wang, Hantao Liu, Silke Miller, Ki Jeong Lee, Zhulun Wang, Murielle M Véniant
In search of metabolically regulated secreted proteins, we conducted a microarray study comparing gene expression in major metabolic tissues of fed and fasted ob/ob mice and C57BL/6 mice. The array used in this study included probes for ~4000 genes annotated as potential secreted proteins. Circulating macrophage inhibitory cytokine 1 (MIC-1)/growth differentiation factor 15 (GDF15) concentrations were increased in obese mice, rats, and humans in comparison to age-matched lean controls. Adeno-associated virus-mediated overexpression of GDF15 and recombinant GDF15 treatments reduced food intake and body weight and improved metabolic profiles in various metabolic disease models in mice, rats, and obese cynomolgus monkeys...
October 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29046199/-association-between-serum-25-oh-d-levels-at-birth-and-bronchopulmonary-dysplasia-in-preterm-infants
#5
Ren-Qiang Yu, Dao-Zhen Chen, Qin Zhou, Min Wang, Ying-Zi Mei, Shan-Yu Jiang
OBJECTIVE: To assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels at birth and bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: This study recruited preterm infants with gestational age of below 34 weeks who were born between January 2014 and December 2016. These preterm infants were classified into two groups: BPD and control. The association between serum 25(OH)D levels at birth and BPD was analyzed. RESULTS: Serum 25(OH)D levels in the BPD group was significantly lower than those in the control group [(37±17 nmol/L vs 47±20 nmol/L; P<0...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29044637/the-modeled-cost-effectiveness-of-family-based-and-adolescent-focused-treatment-for-anorexia-nervosa
#6
Long Khanh-Dao Le, Jan J Barendregt, Phillipa Hay, Susan M Sawyer, Elizabeth K Hughes, Cathrine Mihalopoulos
BACKGROUND: Anorexia nervosa (AN) is a prevalent, serious mental disorder. We aimed to evaluate the cost-effectiveness of family-based treatment (FBT) compared to adolescent-focused individual therapy (AFT) or no intervention within the Australian healthcare system. METHOD: A Markov model was developed to estimate the cost and disability-adjusted life-year (DALY) averted of FBT relative to comparators over 6 years from the health system perspective. The target population was 11-18 year olds with AN of relatively short duration...
October 16, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29044626/the-cost-effectiveness-of-cognitive-behavioral-therapy-for-bulimia-nervosa-in-the-australian-context
#7
Long Khanh-Dao Le, Phillipa Hay, Tracey Wade, Stephen Touyz, Cathrine Mihalopoulos
OBJECTIVE: This study was to model the cost-effectiveness of specialist-delivered cognitive behavioral therapy for bulimia nervosa (CBT-BN) compared to no intervention within the Australian context. METHOD: An illness-death model was developed to estimate the cost per disability-adjusted life-year (DALY) averted of CBT-BN over 2 years from the healthcare perspective. Target population was adults aged 18-65 years with BN. Results are reported as incremental cost-effectiveness ratios (ICER) in 2013 Australian dollars per DALY averted...
October 16, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29043853/microvascular-network-and-its-endothelial-cells-in-the-human-iris
#8
Hongfang Yang, Paula K Yu, Stephen J Cringle, Xinghuai Sun, Dao-Yi Yu
PURPOSE: The iris allows effective delivery of nutrients into the aqueous humor supplying the surrounded avascular tissues. However, possible underlying mechanisms of the iris vasculature have not been well established. This study aims to quantitatively assess the human iris vascular network, endothelial cell morphometries, and characterize endothelial junctions to better understand the properties of the iris vasculature. MATERIALS AND METHODS: The irises from human donor eyes were dissected and short fixed before float staining for VE-cadherin and claudin-5, f-actin and nuclei and flat-mounted for confocal imaging...
October 18, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29042553/molecular-analysis-of-high-grade-serous-ovarian-carcinoma-with-and-without-associated-serous-tubal-intra-epithelial-carcinoma
#9
Jennifer Ducie, Fanny Dao, Michael Considine, Narciso Olvera, Patricia A Shaw, Robert J Kurman, Ie-Ming Shih, Robert A Soslow, Leslie Cope, Douglas A Levine
Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~ 50% of advanced stage cases. To better understand the molecular etiology of HGSCs, we report a multi-center integrated genomic analysis of advanced stage tumors with and without STIC lesions and normal tissues. The most significant focal DNA SCNAs were shared between cases with and without STIC lesions...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29039862/a-pair-of-3d-enantiotopic-zinc-ii-complexes-based-on-two-asymmetric-achiral-ligands
#10
Ming-Dao Zhang, Yan-Le Li, Zhen-Zhen Shi, He-Gen Zheng, Jing Ma
Enantiomorphism and enantioselectivity are critical in biology and many other applications. Herein, we report two 3D chiral MOFs {[Zn6(MIDPPA)3(1,2,4-btc)3(NO2)3(H2O)3](H2O)7}n (1L and 1R) based on achiral ligands with high enantiomeric excess and a novel topological type. The internal mechanism of spontaneous chiral symmetry breaking, during the crystallization of chiral MOFs based on achiral ligands, is elucidated for the first time from both structural and theoretical aspects. Hydrogen bonds are found to play a key role in the spontaneous symmetry breaking of chiral MOFs...
October 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29031911/gene-polymorphisms-of-disc1-is-associated-with-schizophrenia-evidence-from-a-meta-analysis
#11
REVIEW
Hong-Yu Wang, Yong Liu, Jun-Wei Yan, Xing-Long Hu, Dao-Min Zhu, Xiao-Tong Xu, Xiao-Si Li
BACKGROUND: Previous studies suggest an association between Disrupted in schizophrenia 1 (DISC1) polymorphisms and schizophrenia (SCZ). However, the available data are often inconsistent, regarding the difference in sample size, ethnicity, genotyping method, etc. Thus, we carried out a meta-analysis to determine whether DISC1 polymorphisms contributed susceptibility to SCZ. METHODS: A methodical literature review was operated using the English and Chinese core electronic databases...
October 12, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29028053/subwavelength-dielectric-nanorod-chains-for-energy-transfer-in-the-visible-range
#12
Dongdong Li, Jingjing Zhang, Changchun Yan, Zhengji Xu, Dao Hua Zhang
We report a new type of energy transfer device, formed by a dielectric nanorod array embedded in a silver slab. Such dielectric chain structures allow surface plasmon wave guiding with large propagation length and highly suppressed crosstalk between adjacent transmission channels. The simulation results show that our proposed design can be used to enhance the energy transfer along the waveguide-like dielectric nanorod chains via coupled plasmons, where the energy spreading is effectively suppressed, and superior imaging properties in terms of resolution and energy transfer distance can be achieved...
October 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29027439/-resource-investigation-about-tibetan-medicine-rhodiola-kirilowii
#13
Dao-Xin Hong, Jin-Song Su, Jian Wen, Jing Zhang, Yi Zhang
The investigation aims to better understand the resource status of Rhodiola kirilowii, analysis the suitable habitat of wild Rh. kirilowii and protect the wild resources of Rh. Kirilowii, promoting the sustainable utilization of Rh. kirilowii resources. In this paper, we investigated the wild resources of Rh. kirilowii in 16 counties of Sichuan, Qinghai, Gansu and Yunnan by means of investigation and sampling investigation combined with interview. The results showed that the population densities of wild Rh...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29024763/slow-reading-in-children-with-anisometropic-amblyopia-is-associated-with-fixation-instability-and-increased-saccades
#14
Krista R Kelly, Reed M Jost, Angie De La Cruz, Lori Dao, Cynthia L Beauchamp, David Stager, Eileen E Birch
BACKGROUND: Previous studies show slow reading in strabismic amblyopia. We recently identified amblyopia, not strabismus, as the key factor in slow reading in children. No studies have focused on reading in amblyopic children without strabismus. We examined reading in anisometropic children and evaluated whether slow reading was associated with ocular motor dysfunction in children with amblyopia. METHODS: Anisometropic children (7-12 years) with or without amblyopia were compared to age-similar normal controls...
October 9, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29023875/optimal-endpoint-for-catheter-ablation-of-longstanding-persistent-atrial-fibrillation-a-randomized-clinical-trial
#15
Yuan-Long Wang, Xu Liu, Yu Zhang, Wei-Feng Jiang, Li Zhou, Mu Qin, Dao-Liang Zhang, Xiao-Dong Zhang, Shao-Hui Wu, Kai Xu
BACKGROUND: In longstanding persistent atrial fibrillation (LPeAF), the ideal endpoint of ablation remains to be determined. This study aims to evaluate the value of pursuing AF termination or no with the same strategy during ablation on the long-term outcomes in patients with LPeAF. METHODS: Utilized "CCL" strategy is a fixed ablation approach consisting of circumferential pulmonary vein antrum isolation (CPVI), ablation of complex fractionated atrial electrogram (CFAE), and linear ablation between fied anatomical structures (the mitral isthmus, left atrial roof)...
October 10, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29023534/bewith-a-between-within-method-to-discover-relationships-between-cancer-modules-via-integrated-analysis-of-mutual-exclusivity-co-occurrence-and-functional-interactions
#16
Phuong Dao, Yoo-Ah Kim, Damian Wojtowicz, Sanna Madan, Roded Sharan, Teresa M Przytycka
The analysis of the mutational landscape of cancer, including mutual exclusivity and co-occurrence of mutations, has been instrumental in studying the disease. We hypothesized that exploring the interplay between co-occurrence, mutual exclusivity, and functional interactions between genes will further improve our understanding of the disease and help to uncover new relations between cancer driving genes and pathways. To this end, we designed a general framework, BeWith, for identifying modules with different combinations of mutation and interaction patterns...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29023004/selection-of-drought-tolerant-maize-hybrids-using-path-coefficient-analysis-and-selection-index
#17
Abdalla Dao, Jacob Sanou, Edgar V S Traore, Vernon Gracen, Eric Y Danquah
BACKGROUND: In drought-prone environments, direct selection for yield is not adequate because of the variable environment and genotype x environment interaction. Therefore, the use of secondary traits in addition to yield has been suggested. The relative usefulness of secondary traits as indirect selection criteria for maize grain yield is determined by the magnitudes of their genetic variance, heritability and genetic correlation with the grain yield. MATERIALS AND METHODS: Forty eight testcross hybrids derived from lines with different genetic background and geographical origins plus 7 checks were evaluated in both well-watered and water-stressed conditions over two years for grain yield and secondary traits to determine the most appropriate secondary traits and select drought tolerant hybrids...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022381/effects-of-probiotic-bacteria-on-mucosal-polyamines-levels-in-dogs-with-ibd-and-colonic-polyps-a-preliminary-study
#18
G Rossi, M Cerquetella, S Scarpona, G Pengo, K Fettucciari, G Bassotti, A E Jergens, J S Suchodolski
Spermine (SPM) and its precursor putrescine (PUT), regulated by ornithine decarboxylase (ODC) and diamino-oxidase (DAO), are polyamines required for cell growth and proliferation. Only a few studies have investigated the anti-inflammatory and tumour inhibitory properties of probiotics on mucosal polyamine levels. We investigated the effects of a high concentration multistrain probiotic for human use on colonic polyamine biosynthesis in dogs. Histological sections (inflammatory bowel disease, n=10; polyposis, n=5) were assessed after receiving 112 to 225×10(9) lyophilised bacteria daily for 60 days at baseline (T0) and 30 days after treatment end (T90)...
October 12, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29020629/differential-regulation-of-lipoprotein-and-hepatitis-c-virus-secretion-by-rab1b
#19
Constantin N Takacs, Ursula Andreo, Viet Loan Dao Thi, Xianfang Wu, Caroline E Gleason, Michelle S Itano, Gabriella S Spitz-Becker, Rachel L Belote, Brenna R Hedin, Margaret A Scull, Charles M Rice, Sanford M Simon
Secretory cells produce diverse cargoes, yet how they regulate concomitant secretory traffic remains insufficiently explored. Rab GTPases control intracellular vesicular transport. To map secretion pathways, we generated a library of lentivirus-expressed dominant-negative Rab mutants and used it in a large-scale screen to identify regulators of hepatic lipoprotein secretion. We identified several candidate pathways, including those mediated by Rab11 and Rab8. Surprisingly, inhibition of Rab1b, the major regulator of transport from the endoplasmic reticulum to the Golgi, differently affected the secretion of the very-low-density lipoprotein components ApoE and ApoB100, despite their final association on mature secreted lipoprotein particles...
October 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/29020015/anti-inflammatory-and-wound-healing-activities-of-calophyllolide-isolated-from-calophyllum-inophyllum-linn
#20
Van-Linh Nguyen, Cong-Tri Truong, Binh Cao Quan Nguyen, Thanh-Niem Van Vo, Trong-Thuc Dao, Van-Dan Nguyen, Dieu-Thuong Thi Trinh, Hieu Kim Huynh, Chi-Bao Bui
Due to the high-cost and limitations of current wound healing treatments, the search for alternative approaches or drugs, particularly from medicinal plants, is of key importance. In this study, we report anti-inflammatory and wound healing activities of the major calophyllolide (CP) compound isolated from Calophyllum inophyllum Linn. The results showed that CP had no effect on HaCaT cell viability over a range of concentrations. CP reduced fibrosis formation and effectively promoted wound closure in mouse model without causing body weight loss...
2017: PloS One
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