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https://www.readbyqxmd.com/read/29682876/soybean-lecithin-mediated-nanoporous-plga-microspheres-with-highly-entrapped-and-controlled-released-bmp-2-as-a-stem-cell-platform
#1
Daixu Wei, Ruirui Qiao, Jinwei Dao, Jing Su, Chengmin Jiang, Xichang Wang, Mingyuan Gao, Jian Zhong
Injectable polymer microsphere-based stem cell delivery systems have a severe problem that they do not offer a desirable environment for stem cell adhesion, proliferation, and differentiation because it is difficult to entrap a large number of hydrophilic functional protein molecules into the core of hydrophobic polymer microspheres. In this work, soybean lecithin (SL) is applied to entrap hydrophilic bone morphogenic protein-2 (BMP-2) into nanoporous poly(lactide-co-glycolide) (PLGA)-based microspheres by a two-step method: SL/BMP-2 complexes preparation and PLGA/SL/BMP-2 microsphere preparation...
April 22, 2018: Small
https://www.readbyqxmd.com/read/29682664/liquid-marble-coalescence-via-vertical-collision
#2
Jing Jin, Chin Hong Ooi, Dzung Viet Dao, Nam-Trung Nguyen
The coalescence process of liquid marbles is vital to their promising roles as reactors or mixers in digital microfluidics. However, the underlying mechanisms and critical conditions of liquid marble coalescence are not well understood. This paper studies the coalescence process of two equally-sized liquid marbles via vertical collision aided by dielectrophoretic handling. A liquid marble was picked up using the dielectrophoretic force and then dropped vertically onto another liquid marble resting on a hydrophobic powder bed...
April 23, 2018: Soft Matter
https://www.readbyqxmd.com/read/29679053/pregnancy-associated-diamine-oxidase-originates-from-extravillous-trophoblasts-and-is-decreased-in-early-onset-preeclampsia
#3
Philipp Velicky, Karin Windsperger, Karin Petroczi, Sophie Pils, Birgit Reiter, Tamara Weiss, Sigrid Vondra, Robin Ristl, Sabine Dekan, Christian Fiala, David E Cantonwine, Thomas F McElrath, Bernd Jilma, Martin Knöfler, Thomas Boehm, Jürgen Pollheimer
Human extravillous trophoblast (EVT) invasion of the pregnant uterus constitutes a pivotal event for the establishment of the maternal-fetal interface. Compromised EVT function manifesting in inadequate arterial remodeling is associated with the severe pregnancy disorder early-onset preeclampsia (eoPE). Recent studies suggest that EVTs invade the entire uterine vasculature including arteries, veins and lymphatics in the first trimester of pregnancy. We therefore hypothesized that EVT-derived factors accumulate in the circulation of pregnant women early in gestation and may serve to predict eoPE...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678166/why-does-my-patient-s-basilar-artery-continue-to-grow-a-four-year-case-study-of-a-patient-with-symptoms-of-vertebrobasilar-dolichoectasia
#4
Dao Pei Zhang, Yan Fang Peng, Qian Kun Ma, Min Zhao, Huai Liang Zhang, Suo Yin
BACKGROUND: Vertebrobasilar dolichoectasia (VBD) is a clinical entity associated with ischemic stroke, compression of cranial nerves or brainstem, and hydrocephalus. There have been relatively few studies following the progression of VBD in patients presenting with a variety of diverse clinical features. CASE PRESENTATION: Here, we report a case study of a male with progressive VBD who was followed from November 2012 to December 2016. The patient had diagnosed hypertension for several years and suffered from left peripheral facial paralysis, recurrent ischemic attacks in the brainstem and cerebellum, obstructive hydrocephalus and frequent pneumonia...
April 20, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29675469/noninvasive-ovarian-cancer-biomarker-detection-via-an-optical-nanosensor-implant
#5
Ryan M Williams, Christopher Lee, Thomas V Galassi, Jackson D Harvey, Rachel Leicher, Maria Sirenko, Madeline A Dorso, Janki Shah, Narciso Olvera, Fanny Dao, Douglas A Levine, Daniel A Heller
Patients with high-grade serous ovarian carcinoma (HGSC) exhibit poor 5-year survival rates, which may be significantly improved by early-stage detection. The U.S. Food and Drug Administration-approved biomarkers for HGSC-CA-125 (cancer antigen 125) and HE4 (human epididymis protein 4)-do not generally appear at detectable levels in the serum until advanced stages of the disease. An implantable device placed proximal to disease sites, such as in or near the fallopian tube, ovary, uterine cavity, or peritoneal cavity, may constitute a feasible strategy to improve detection of HGSC...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29674589/ultralarge-elastic-deformation-of-nanoscale-diamond
#6
Amit Banerjee, Daniel Bernoulli, Hongti Zhang, Muk-Fung Yuen, Jiabin Liu, Jichen Dong, Feng Ding, Jian Lu, Ming Dao, Wenjun Zhang, Yang Lu, Subra Suresh
Diamonds have substantial hardness and durability, but attempting to deform diamonds usually results in brittle fracture. We demonstrate ultralarge, fully reversible elastic deformation of nanoscale (~300 nanometers) single-crystalline and polycrystalline diamond needles. For single-crystalline diamond, the maximum tensile strains (up to 9%) approached the theoretical elastic limit, and the corresponding maximum tensile stress reached ~89 to 98 gigapascals. After combining systematic computational simulations and characterization of pre- and postdeformation structural features, we ascribe the concurrent high strength and large elastic strain to the paucity of defects in the small-volume diamond nanoneedles and to the relatively smooth surfaces compared with those of microscale and larger specimens...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29672292/identification-of-risk-factors-in-high-dose-methotrexate-induced-acute-kidney-injury-in-childhood-acute-lymphoblastic-leukemia
#7
Dao-Hai Cheng, Hua Lu, Tao-Tao Liu, Xiao-Qin Zou, Hui-Mei Pang
AIMS: Although high-dose methotrexate (HDMTX) is an effective means for the treatment of acute lymphoblastic leukemia (ALL), the development of renal dysfunction remains a significant management challenge. This study aimed to identify the key factors in HDMTX-induced acute kidney injury (AKI) in childhood ALL. METHODS: We retrospectively analyzed the clinical data in 1,329 courses of HDMTX treatment in 336 Chinese ALL children at the First Affiliated Hospital of Guangxi Medical University from September 2012 to November 2016...
April 19, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29664829/nipple-sparing-mastectomy-and-immediate-breast-reconstruction-with-a-deep-inferior-epigastric-perforator-flap-a-study-of-patient-satisfaction
#8
Jerry Levy, Romain Bosc, Noel Warren, Sabban Rebecca, Thu Ha Dao, Barbara Hersant, Jean-Paul Meningaud
INTRODUCTION: The morphological result of nipple-areola complex (NAC) reconstruction may be disappointing for patients who undergo skin-sparing mastectomies and immediate breast reconstruction, followed by secondary reconstruction of the nipple-areola complex.The aim of this study was to analyze patient satisfaction after nipple-sparing mastectomy and immediate breast reconstruction with a deep inferior epigastric perforator flap. MATERIALS AND METHODS: Our retrospective study involved all patients who underwent an immediate breast reconstruction after unilateral mastectomy with conservation of the NAC...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29663511/extra-hepatic-cancers-are-the-leading-cause-of-death-in-cirrhotic-patients-achieving-hbv-control-or-hcv-eradication
#9
Manon Allaire, Pierre Nahon, Richard Layese, Valérie Bourcier, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Eric Nguyen-Khac, Brigitte Bernard-Chabert, David Zucman, Vincent Di Martino, Angela Sutton, Eric Letouzé, Etienne Audureau, Françoise Roudot-Thoraval
BACKGROUND: Data on extrahepatic cancers (EHC) in compensated viral cirrhosis are limited. The objective of the prospective multicenter ANRS CO12 CirVir cohort was to assess the occurrence of all clinical events in patients with compensated viral cirrhosis, including all types of cancer. METHODS: Patients with the following inclusion criteria were enrolled in 35 French centers: a) biopsy-proven HBV or HCV cirrhosis; b) Child-Pugh A; c) absence of previous liver complications including primary liver cancer (PLC)...
April 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29660242/iridoids-from-pedicularis-verticillata-and-their-anti-complementary-activity
#10
Ming-Hui Shao, Wei Dai, Si-Wen Yuan, Yan Lu, Dao-Feng Chen, Qi Wang
Three new iridoids named as pediverticilatasin A - C (1 - 3, resp.), together with five known iridoids (4 - 8, resp.) were isolated from the whole plants of Pedicularis verticillata. The structures of three new compounds were identified as (1S,7R)-1-ethoxy-7-hydroxy-7-methyl-1,5,6,7-tetrahydrocyclopenta[c]pyran-4(3H)-one (1), (1S,4aS,7R,7aS)-1,4a,5,6,7,7a-hexahydro-1-ethoxy-7-hydroxy-7-methyl-cyclopenta[c]pyran-4-carboxylic acid (2), (1S,4aS,7R,7aS)-1,4a,5,6,7,7a-hexahydro-1-ethoxy-7-hydroxy-7-methyl-cyclopenta[c]pyran-4-carbaldehyde (3)...
April 16, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29660235/inhibition-of-ossweet11-function-in-mesophyll-cells-improves-resistance-of-rice-to-sheath-blight-disease
#11
Yue Gao, Chong Zhang, Xiao Han, Zi Yuan Wang, Lai Ma, De Peng Yuan, Jing Ni Wu, Xiao Feng Zhu, Jing Miao Liu, Dao Pin Li, Yi Bing Hu, Yuan Hu Xuan
Pathogen-host interaction is a complicated process; pathogens mainly infect host plants to acquire nutrients, especially sugars. Rhizoctonia solani, the causative agent of sheath blight disease, is a major pathogen of rice. However, it is not known, as to how this pathogen obtains sugar from rice plants. In this study, we found that the rice sugar transporter, OsSWEET11 is involved in the pathogenesis of sheath blight disease. qRT-PCR and β-d-glucuronidase expression analyses showed that R. solani infection significantly enhanced OsSWEET11 expression in leaves among the clade III SWEET members...
April 16, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29659121/glucagon-like-peptide-1-ameliorates-cardiac-lipotoxicity-in-diabetic-cardiomyopathy-via-the-ppar%C3%AE-pathway
#12
Lujin Wu, Ke Wang, Wei Wang, Zheng Wen, Peihua Wang, Lei Liu, Dao Wen Wang
Lipotoxicity cardiomyopathy is the result of excessive accumulation and oxidation of toxic lipids in the heart. It is a major threat to patients with diabetes. Glucagon-like peptide-1 (GLP-1) has aroused considerable interest as a novel therapeutic target for diabetes mellitus because it stimulates insulin secretion. Here, we investigated the effects and mechanisms of the GLP-1 analog exendin-4 and the dipeptidyl peptidase-4 inhibitor saxagliptin on cardiac lipid metabolism in diabetic mice (DM). The increased myocardial lipid accumulation, oxidative stress, apoptosis, and cardiac remodeling and dysfunction induced in DM by low streptozotocin doses and high-fat diets were significantly reversed by exendin-4 and saxagliptin treatments for 8 weeks...
April 16, 2018: Aging Cell
https://www.readbyqxmd.com/read/29659018/vmat-optimization-with-dynamic-collimator-rotation
#13
Qihui Lyu, Daniel O'Connor, Dan Ruan, Victoria Yu, Dan Nguyen, Ke Sheng
PURPOSE: Although collimator rotation is an optimization variable that can be exploited for dosimetric advantages, existing Volumetric Modulated Arc Therapy (VMAT) optimization uses a fixed collimator angle in each arc and only rotates the collimator between arcs. In this study, we develop a novel integrated optimization method for VMAT, accounting for dynamic collimator angles during the arc motion. METHODS: Direct Aperture Optimization (DAO) for Dynamic Collimator in VMAT (DC-VMAT) was achieved by adding to the existing dose fidelity objective an anisotropic total variation term for regulating the fluence smoothness, a binary variable for forming simple apertures, and a group sparsity term for controlling collimator rotation...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29644789/construction-of-holliday-junction-in-small-circular-dna-molecules-for-stable-motifs-and-two-dimensional-lattices
#14
Xin Guo, Xue-Mei Wang, Shuai Wei, Shou-Jun Xiao
Design rules for DNA nanotechnology have been mostly learnt from using linear single stranded (ss) DNAs as the source materials. For example, a typical DAO (Double crossover, Antiparallel, Odd half turns) tile for assembling two-dimensional (2D) lattices is built by only two linear ss-oligonucleotide scaffold strands, like two ropes making a square knot. We demonstrate here a new type of coupled DAO (cDAO) tiles and their 2D lattices using small circular ss-oligonucleotides as scaffold strands and linear ss-oligonucleotides as staple strands...
April 12, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29643033/-vaspin-protects-against-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-in-mice-by-inhibiting-inflammation-and-protecting-vascular-endothelium-via-pi3k-akt-signal-pathway
#15
Wen Li, Di Qi, Lan Chen, Yan Zhao, Wang Deng, Xu-Mao Tang, Dao-Xin Wang
OBJECTIVE: To investigate the effects of Vaspin on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) in mice and explore the possible mechanism. METHODS: Forty male C57B/L6 mice were randomized equally into control group, LPS group, Vaspin group and wortmannin group with corresponding treatments. The pathological changes of the lung tissues were evaluated by HE staining, and the severity of pulmonary edema was measured according to the wet/dry ratio (W/D) of the lung tissue...
March 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29628017/snail-borne-parasitic-diseases-an-update-on-global-epidemiological-distribution-transmission-interruption-and-control-methods
#16
REVIEW
Xiao-Ting Lu, Qiu-Yun Gu, Yanin Limpanont, Lan-Gui Song, Zhong-Dao Wu, Kamolnetr Okanurak, Zhi-Yue Lv
BACKGROUND: Snail-borne parasitic diseases, such as angiostrongyliasis, clonorchiasis, fascioliasis, fasciolopsiasis, opisthorchiasis, paragonimiasis and schistosomiasis, pose risks to human health and cause major socioeconomic problems in many tropical and sub-tropical countries. In this review we summarize the core roles of snails in the life cycles of the parasites they host, their clinical manifestations and disease distributions, as well as snail control methods. MAIN BODY: Snails have four roles in the life cycles of the parasites they host: as an intermediate host infected by the first-stage larvae, as the only intermediate host infected by miracidia, as the first intermediate host that ingests the parasite eggs are ingested, and as the first intermediate host penetrated by miracidia with or without the second intermediate host being an aquatic animal...
April 9, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29626651/autophagy-as-a-common-pathway-in-amyotrophic-lateral-sclerosis
#17
REVIEW
Dao K H Nguyen, Ravi Thombre, Jiou Wang
Age-dependent neurodegenerative diseases are associated with a decline in protein quality control systems including autophagy. Amyotrophic lateral sclerosis (ALS) is a motor neuron degenerative disease of complex etiology with increasing connections to other neurodegenerative conditions such as frontotemporal dementia. Among the diverse genetic causes for ALS, a striking feature is the common connection to autophagy and its associated pathways. There is a recurring theme of protein misfolding as in other neurodegenerative diseases, but importantly there is a distinct common thread among ALS genes that connects them to the cascade of autophagy...
April 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29625480/microvascular-density-is-associated-with-retinal-ganglion-cell-axonal-volume-in-the-laminar-compartments-of-the-human-optic-nerve-head
#18
Min H Kang, Mengchen Suo, Chandrakumar Balaratnasingam, Paula K Yu, William H Morgan, Dao-Yi Yu
Purpose: To quantify associations between microvascular density and retinal ganglion cell (RGC) axonal volume in the laminar compartments of the human optic nerve head (ONH). Methods: Eleven normal human ONHs were evaluated. Antibodies were used to label the vascular endothelium (factor VIII-related antigen/von Willebrand factor antibody) and RGC axons (neurofilament heavy antibody). Three-dimensional analysis of confocal scanning laser microscope images was used to study microvascular density and RGC axonal volume in the prelaminar, anterior lamina cribrosa, posterior lamina cribrosa, and retrolaminar compartments...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625442/improved-binocular-outcomes-following-binocular-treatment-for-childhood-amblyopia
#19
Krista R Kelly, Reed M Jost, Yi-Zhong Wang, Lori Dao, Cynthia L Beauchamp, Joel N Leffler, Eileen E Birch
Purpose: Childhood amblyopia can be treated with binocular games or movies that rebalance contrast between the eyes, which is thought to reduce depth of interocular suppression so the child can experience binocular vision. While visual acuity gains have been reported following binocular treatment, studies rarely report gains in binocular outcomes (i.e., stereoacuity, suppression) in amblyopic children. Here, we evaluated binocular outcomes in children who had received binocular treatment for childhood amblyopia...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625242/soya-saponins-induce-intestinal-inflammation-and-barrier-dysfunction-in-juvenile-turbot-scophthalmus-maximus
#20
Min Gu, Qian Jia, Zhiyu Zhang, Nan Bai, Xiaojie Xu, Bingying Xu
Soybean meal-induced enteritis (SBMIE) is a well-described condition in the distal intestine (DI) of several cultured fish species, but the exact cause is still unclear. The work on Atlantic salmon and zebrafish suggested soya-saponins, as heat-stable anti-nutritional factors in soybean meal, are the major causal agents. However, this conclusion was not supported by the research on some other fish, such as gilthead sea bream and European sea bass. Our previous work proved that soybean could induce SBMIE on turbot and the present work aimed to investigate whether soya-saponins alone could cause SBMIE and the effects of soya-saponins on the intestinal barrier function in juvenile turbot...
April 3, 2018: Fish & Shellfish Immunology
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