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https://www.readbyqxmd.com/read/28336306/efficacy-of-acellular-nerve-allografts-in-trigeminal-nerve-reconstruction
#1
Andrew Yampolsky, Vincent Ziccardi, Sung-Kiang Chuang
PURPOSE: During trigeminal nerve repair, a gap is sometimes encountered that prevents the tension-free apposition of nerve endings. The use of a processed acellular nerve allograft is a novel technique that shows promise in overcoming this problem. The goal of the present study was to support the slowly evolving body of evidence that acellular processed nerve allografts (Avance; Axogen, Alachua, FL) are a viable alternative to autogenous nerve grafting and the use of conduits for reconstructing defects of the trigeminal nerve...
February 27, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28335766/barriers-to-the-conduct-and-application-of-research-in-complementary-and-alternative-medicine-a-systematic-review
#2
Yasamin Veziari, Matthew J Leach, Saravana Kumar
BACKGROUND: The popularity of Complementary and alternative medicine (CAM) has grown considerably over the past few decades. This has been accompanied by increasing public pressure for CAM to be evidence-based. Notwithstanding, the conduct and application of research in CAM faces a number of obstacles. No systematic review has mapped these barriers to date. Therefore, this systematic literature review aimed to explore, identify and map the barriers to the conduct and application of research in CAM...
March 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28333867/determining-risk-of-severe-gastrointestinal-toxicity-based-on-pretreatment-gut-microbial-community-in-patients-receiving-cancer-treatment-a-new-predictive-strategy-in-the-quest-for-personalized-cancer-medicine
#3
Hannah R Wardill, Wim J E Tissing
PURPOSE OF REVIEW: Currently, our ability to accurately predict a patient's risk of developing severe gastrointestinal toxicity from their cancer treatment is limited. Risk stratification continues to rely on traditional patient-related and treatment-related factors including age, ethnicity, sex, comorbidities, genetics, agent, dose and schedule. Although informative, these crude measures continue to underestimate toxicity risk, and hence alternative methods of risk prediction must be investigated...
March 22, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28330725/a-botanical-phytochemical-and-ethnomedicinal-review-of-the-genus-mitragyna-korth-implications-for-products-sold-as-kratom
#4
REVIEW
Paula N Brown, Jensen A Lund, Susan J Murch
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Mitragyna (Rubiacaeae) has been traditionally used in parts of Africa, Asia and Oceania. In recent years, there has been increased interest in species of Mitragyna with the introduction of products to western markets and regulatory uncertainty. AIM OF THE STUDY: This paper reviewed the traditional ethnomedicinal uses of leaves for species belonging to the genus Mitragyna with reference to the botany and known chemistry in order to highlight areas of interest for products currently being sold as kratom...
March 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28328840/osteopathic-manipulative-treatment-showed-reduction-of-length-of-stay-and-costs-in-preterm-infants-a-systematic-review-and-meta-analysis
#5
Diego Lanaro, Nuria Ruffini, Andrea Manzotti, Gianluca Lista
BACKGROUND: Osteopathic medicine is an emerging and complementary method used in neonatology. METHODS: Outcomes were the mean difference in length of stay (LOS) and costs between osteopathy and alternative treatment group. A comprehensive literature search of (quasi)- randomized controlled trials (RCTs), was conducted from journal inception to May, 2015. Eligible studies must have treated preterm infants directly in the crib or bed and Osteopathic Manipulative Treatment (OMT) must have been performed by osteopaths...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28325144/therapeutic-potential-and-outlook-of-alternative-medicine-for-osteoporosis
#6
Tao Wang, Qian Liu, William Tjhioe, Jinmin Zhao, Aiping Lu, Ge Zhang, Renxiang Tan, Mengyu Zhou, Jiake Xu, Haotian Feng
Osteoporosis, a bone disease resulting in loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone some concern has been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy...
March 21, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28321921/insights-into-cell-free-therapeutic-approach-role-of-stem-cell-soup-ernatant
#7
REVIEW
Shalini Raik, Ajay Kumar, Shalmoli Bhattacharyya
Current advances in medicine have revolutionized the field of regenerative medicine dramatically with newly evolved therapies for repair or replacement of degenerating or injured tissues. Stem cells can be harvested from different sources for clinical therapeutics which include fetal tissues, umbilical cord blood, embryos and adult tissues. Stem cells can be isolated and differentiated into desired lineages for tissue regeneration and cell replacement therapy. However, several loopholes need to be addressed properly before this can be extended for large scale therapeutic application...
March 21, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28317239/the-use-of-low-dose-metronomic-chemotherapy-in-dogs-insight-into-a-modern-cancer-field
#8
REVIEW
T B Gaspar, J Henriques, L Marconato, F L Queiroga
The era of chemotherapy, which started in the middle of the last century, has been ruled by the routine use of dose-intense protocols, based on the "maximum-tolerated dose" concept. By promoting a balance between patient's quality of life and the goal of rapidly killing as many tumour cells as possible, these protocols still play a prominent role in veterinary oncology. However, with the opening of a new millennium, metronomic chemotherapy (MC) started to be considered a possible alternative to traditional dose-intense chemotherapy...
March 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28316783/current-and-future-prospects-for-nanotechnology-in-animal-production
#9
REVIEW
Emily K Hill, Julang Li
Nanoparticles have been used as diagnostic and therapeutic agents in the human medical field for quite some time, though their application in veterinary medicine and animal production is still relatively new. Recently, production demands on the livestock industry have been centered around the use of antibiotics as growth promoters due to growing concern over microbial antibiotic resistance. With many countries reporting increased incidences of antibiotic-resistant bacteria, laws and regulations are being updated to end in-feed antibiotic use in the animal production industry...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28316635/epigenetic-mechanisms-of-integrative-medicine
#10
REVIEW
Riya R Kanherkar, Susan E Stair, Naina Bhatia-Dey, Paul J Mills, Deepak Chopra, Antonei B Csoka
Since time immemorial humans have utilized natural products and therapies for their healing properties. Even now, in the age of genomics and on the cusp of regenerative medicine, the use of complementary and alternative medicine (CAM) approaches represents a popular branch of health care. Furthermore, there is a trend towards a unified medical philosophy referred to as Integrative Medicine (IM) that represents the convergence of CAM and conventional medicine. The IM model not only considers the holistic perspective of the physiological components of the individual, but also includes psychological and mind-body aspects...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28315070/mechanisms-of-resistance-in-multiple-myeloma
#11
Athanasios Papadas, Fotis Asimakopoulos
Multiple myeloma (MM) is an incurable hematopoietic cancer that is characterized by malignant plasma cell infiltration of the bone marrow and/or extramedullary sites. Multi-modality approaches including "novel agents," traditional chemotherapy, and/or stem cell transplantation are used in MM therapy. Drug resistance, however, ultimately develops and the disease remains incurable for the vast majority of patients. In this chapter, we review both tumor cell-autonomous and non-autonomous (microenvironment-dependent) mechanisms of drug resistance...
March 18, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28306666/new-biomarkers-and-imaging-approaches-for-the-diagnosis-of-deep-venous-thrombosis
#12
Jordan K Schaefer, Benjamin Jacobs, Thomas W Wakefield, Suman L Sood
PURPOSE OF REVIEW: Symptoms suggestive of deep vein thrombosis (DVT) are extremely common in clinical practice, but unfortunately nonspecific. In both ambulatory and inpatient settings, clinicians are often tasked with evaluating these concerns. Here, we review the most recent advances in biomarkers and imaging to diagnose lower extremity DVT. RECENT FINDINGS: The modified Wells score remains the most supported clinical decision rule for risk stratifying patients...
March 16, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28296342/delivery-of-growth-factor-based-therapeutics-in-vascular-diseases-challenges-and-strategies
#13
REVIEW
He-Lin Xu, Wen-Ze Yu, Cui-Tao Lu, Xiao-Kun Li, Ying-Zheng Zhao
Either cardiovascular or peripheral vascular diseases have become the major cause of morbidity and mortality worldwide. Recently, growth factors therapeutics, whatever administrated in form of exogenous growth factors or their relevant genes have been discovered to be an effective strategy for the prevention and therapy of vascular diseases, because of their promoting angiogenesis. Besides, as an alternative, stem cell-based therapy has been also developed in view of their paracrine-mediated effect or ability of differentiation toward angiogenesis-related cells under assistance of growth factors...
March 10, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28295000/current-status-of-radiopharmaceuticals-for-the-theranostics-of-neuroendocrine-neoplasms
#14
REVIEW
Melpomeni Fani, Petra Kolenc Peitl, Irina Velikyan
Nuclear medicine plays a pivotal role in the management of patients affected by neuroendocrine neoplasms (NENs). Radiolabeled somatostatin receptor analogs are by far the most advanced radiopharmaceuticals for diagnosis and therapy (radiotheranostics) of NENs. Their clinical success emerged receptor-targeted radiolabeled peptides as an important class of radiopharmaceuticals and it paved the way for the investigation of other radioligand-receptor systems. Besides the somatostatin receptors (sstr), other receptors have also been linked to NENs and quite a number of potential radiolabeled peptides have been derived from them...
March 15, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28292796/hand-arm-vibration-syndrome-what-family-physicians-should-know
#15
REVIEW
Shixin Cindy Shen, Ronald A House
OBJECTIVE: To provide family physicians with an understanding of the epidemiology, pathogenesis, symptoms, diagnosis, and management of hand-arm vibration syndrome (HAVS), an important and common occupational disease in Canada. SOURCES OF INFORMATION: A MEDLINE search was conducted for research and review articles on HAVS. A Google search was conducted to obtain gray literature relevant to the Canadian context. Additional references were obtained from the articles identified...
March 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28291990/medicinal-plants-in-the-treatment-of-colitis-evidence-from-preclinical-studies
#16
Marília T Santana, Luana M Cercato, Janaíne P Oliveira, Enilton A Camargo
Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the medicinal plants tested in experimental models of ulcerative colitis. We conducted a systematic literature search through specialized databases (PUBMED, SCOPUS, EMBASE, MEDLINE, LILACS, SCIELO, and SCISEARCH) and selected articles published between January 2000 and June 21, 2016 by using "medicinal plants" and "ulcerative colitis" as key words...
March 14, 2017: Planta Medica
https://www.readbyqxmd.com/read/28286985/use-of-mindfulness-meditation-and-relaxation-to-treat-vasomotor-symptoms
#17
REVIEW
K M Goldstein, M Shepherd-Banigan, R R Coeytaux, J R McDuffie, S Adam, D Befus, A P Goode, A S Kosinski, V Masilamani, J W Williams
Postmenopausal women with bothersome vasomotor symptoms (VMS) often seek alternatives to hormone-based treatment due to medication risks or personal preference. We sought to identify the effects of meditation, mindfulness, hypnosis and relaxation on VMS and health-related quality of life in perimenopausal and postmenopausal women. To do this, we conducted an umbrella review supplemented by new randomized, controlled trials (RCTs) published since the most recent good-quality systematic review for eligible interventions...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28286776/the-efficacy-of-acupuncture-for-treating-depression-related-insomnia-compared-with-a-control-group-a-systematic-review-and-meta-analysis
#18
REVIEW
Bo Dong, Zeqin Chen, Xuan Yin, Danting Li, Jie Ma, Ping Yin, Yan Cao, Lixing Lao, Shifen Xu
Objective. To evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia. Data Source. Seven databases were searched starting from 1946 to March 30, 2016. Study Eligibility Criteria. Randomized-controlled trials of adult subjects (18-75 y) who had depression-related insomnia and had received acupuncture. Results. 18 randomized-controlled clinical trials (RCTs) were introduced in this meta-analysis. The findings determined that the acupuncture treatment made significant improvements in PSQI score (MD = -2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28285983/assessing-misclassification-of-vaccination-status-implications-for-studies-of-the-safety-of-the-childhood-immunization-schedule
#19
Matthew F Daley, Jason M Glanz, Sophia R Newcomer, Michael L Jackson, Holly C Groom, Marlene M Lugg, Huong Q McLean, Nicola P Klein, Eric S Weintraub, Michael M McNeil
BACKGROUND: To address public concern about the safety of the childhood immunization schedule, the Institute of Medicine recommended observational studies comparing adverse health outcomes of fully vaccinated children to children under-vaccinated due to parental choice. Misclassification of vaccination status could bias such studies. OBJECTIVE: To assess risk of misclassification of vaccination status within the Vaccine Safety Datalink (VSD). DESIGN/METHODS: A retrospective cohort study was conducted in three phases...
March 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28282104/retrospective-analysis-of-emerging-drugs-use-in-a-quebec-women-s-and-children-s-university-hospital-and-perspectives-for-safe-and-optimal-drug-use
#20
Jennifer Corny, Elaine Pelletier, Denis Lebel, Jean-François Bussières
BACKGROUND: Only few medicines are licensed for children. The use of emerging drugs (unmarketed drug, off-label drug with poorly documented use, and/or costly drugs) might represent an essential alternative for pediatric patients. OBJECTIVES: The objective of the study was to assess emerging drug uses rate and profile in our women's and children's centre to support the implementation of an appropriate policy. METHODS: We identified retrospectively emerging drugs used between 2013-01-01 and 2014-02-28, using computerized pharmacist software extraction of drugs used...
March 10, 2017: Journal of Population Therapeutics and Clinical Pharmacology
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