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https://www.readbyqxmd.com/read/29909405/long-story-short-an-introduction-to-the-short-term-and-long-term-six-sigma-quality-and-its-importance-in-the-laboratory-medicine-for-the-management-of-extra-analytical-processes
#1
Cristiano Ialongo, Sergio Bernardini
There is a compelling need for quality tools that enable effective control of the extra-analytical phase. In this regard, Six Sigma seems to offer a valid methodological and conceptual opportunity, and in recent times, the International Federation of Clinical Chemistry and Laboratory Medicine has adopted it for indicating the performance requirements for non-analytical laboratory processes. However, the Six Sigma implies a distinction between short-term and long-term quality that is based on the dynamics of the processes...
June 18, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29906324/electroacupuncture-treatments-for-gut-motility-disorders
#2
REVIEW
J D Z Chen, M Ni, J Yin
Functional gastrointestinal (GI) diseases are common and there are patients who are refractory to medical therapies as not all treatments work in all patients. Consequently, a large number of patients with functional GI diseases use complementary and alternative medicine, such as acupuncture or electroacupuncture (EA). In this issue, Zheng et al. reported interesting results of a multi-center placebo-controlled clinical study on the use of EA for treating refractory functional dyspepsia; another study reported a multi-center clinical trial on EA for chronic functional constipation; Liang et al...
July 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29904810/colchicine-in-pericardial-disease-from-the-underlying-biology-and-clinical-benefits-to-the-drug-drug-interactions-in-cardiovascular-medicine
#3
REVIEW
Aldo L Schenone, Venu Menon
PURPOSE OF REVIEW: This is an in-depth review on the mechanism of action, clinical utility, and drug-drug interactions of colchicine in the management of pericardial disease. RECENT FINDINGS: Recent evidence about therapeutic targets on pericarditis has demonstrated that NALP3 inflammasome blockade is the cornerstone in the clinical benefits of colchicine. Such benefits extend from acute and recurrent pericarditis to transient constriction and post-pericardiotomy syndrome...
June 14, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29901306/-non-neurogenic-activators-of-myocyte-contraction-and-their-role-in-the-realization-of-the-accumulative-evacuating-functions-of-the-urinary-bladder
#4
V B Berdichevskii, B A Berdichevskii
The search for and use of alternative biomarkers of the hyperactive bladder has garnered increasing attention in recent years because they may be considered pathogenetically significant and used as surrogate biomarkers. Promising agents that have met these criteria include proteins cytokines, neurotrophins, tumor necrosis factor (TNF), nerve growth factor (NGF), fibrinopeptides A and B, C-reactive protein, membrane-bound ATPase. Analysis of current scientific literature has demonstrated that specialists in many fields of medicine show interest in endogenous proteins that do not belong to neurotransmitters but affect the contractile ability of myocytes...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29900477/the-use-of-biosimilars-in-the-middle-east-review-article
#5
REVIEW
Nazar AbdulLateef Jassim, Yasameen Abbas Humadi
PURPOSE OF REVIEW: Biosimilars are of growing importance worldwide, and many leading countries are introducing them in their health care systems and are using them in many fields of medicine owing to their low price tags in comparison with the brands and to their similarities in terms of function and side effects. So we cannot look past them and continue to rely on the innovator drugs since many had proven their efficacies in number of researches and Trials, not to mention the burden that many diseases pose on the budgets of the third world countries making using a lower priced alternatives a much appealing choice for the decision makers...
June 13, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29895763/complementary-medicine-risks-to-infants-and-children
#6
Terry Polevoy
Complementary Alternative Medicine (CAM) that targets infants and children can place them at grave risk. Our plan is to review some of the major cases of CAM used by parents, and by unlicensed and even licensed health professionals. Complications from CAM are rarely the focus of regulatory bodies, or even the courts. Even regulated health professionals, who have profited by misrepresenting science-based evidence for treatment or prevention of disease, have been rarely sanctioned by their respective Boards or Colleges...
June 12, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29895091/-arthroscopic-reconstruction-of-intratendinous-lesions-of-the-supraspinatus-tendon-a-systematic-review
#7
Marius von Knoch, Stephan Frosch, Wolfgang Lehmann
BACKGROUND: Intratendinous lesions of the rotator cuff of the shoulder are frequent and may be a distinct clinical entity. Nevertheless, there are only a few publications which deal specifically with this subject. This study analyses the existing literature for the arthroscopic reconstruction of the intratendinous lesion of the supraspinatus tendon, by means of a systematic review, and identifies relevant research questions for future studies. MATERIAL AND METHODS: In January 2017, a systematic review of the U...
June 12, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29893059/application-of-porcine-gastrointestinal-organoid-units-as-a-potential-in-vitro-tool-for-drug-discovery-and-development
#8
REVIEW
Adedamola Olayanju, Lauren Jones, Karin Greco, Christopher E Goldring, Tahera Ansari
The gastrointestinal tract (GI) is a crucial part of the body for growth and development and its dysregulation can lead to several diseases with detrimental effects. Most of these diseases lack effective treatment, occurring as a result of inappropriate models to develop safe and potent therapies. Organoids are three-dimensional self-organizing and self-renewing structures that are composed of a cluster of different cells in vitro that resemble their organ of origin in architecture and function. Over recent years, organoids have been increasingly used to study developmental biology, disease progression, i...
June 11, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29890662/exploring-the-valuable-carotenoids-for-the-large-scale-production-by-marine-microorganisms
#9
REVIEW
Javier Torregrosa-Crespo, Zaida Montero, Juan Luis Fuentes, Manuel Reig García-Galbis, Inés Garbayo, Carlos Vílchez, Rosa María Martínez-Espinosa
Carotenoids are among the most abundant natural pigments available in nature. These pigments have received considerable attention because of their biotechnological applications and, more importantly, due to their potential beneficial uses in human healthcare, food processing, pharmaceuticals and cosmetics. These bioactive compounds are in high demand throughout the world; Europe and the USA are the markets where the demand for carotenoids is the highest. The in vitro synthesis of carotenoids has sustained their large-scale production so far...
June 8, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29890622/liquid-biopsy-in-oral-cancer
#10
REVIEW
Fatima Lousada-Fernandez, Oscar Rapado-Gonzalez, Jose-Luis Lopez-Cedrun, Rafael Lopez-Lopez, Laura Muinelo-Romay, Maria Mercedes Suarez-Cunqueiro
Oral cancer is one of the most prevalent forms of cancer worldwide. Carcinogenesis is a complex process, in which heterogeneity plays an important role in the development and progression of the disease. This review provides an overview of the current biological and clinical significance of circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), and exosomes for diagnosis and prognosis of oral cancer. We highlight the importance of liquid biopsy—using blood and saliva—which represents a potential alternative to solid biopsy for diagnosis and prognosis...
June 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29887729/analytical-methods-for-the-determination-of-mineral-oil-saturated-hydrocarbons-mosh-and-mineral-oil-aromatic-hydrocarbons-moah-a-short-review
#11
REVIEW
Sandra Weber, Karola Schrag, Gerd Mildau, Thomas Kuballa, Stephan G Walch, Dirk W Lachenmeier
Mineral oils (such as paraffinum liquidum or white oil), which consist of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH), are widely applied in various consumer products such as medicines and cosmetics. Contamination of food with mineral oil may occur by migration of mineral oil containing products from packaging materials, or during the food production process, as well as by environmental contamination during agricultural production. Considerable analytical interest was initiated by the potential adverse health effects, especially carcinogenic effects of some aromatic hydrocarbons...
2018: Analytical Chemistry Insights
https://www.readbyqxmd.com/read/29881389/a-tumor-profile-in-primary-immune-deficiencies-challenges-the-cancer-immune-surveillance-concept
#12
REVIEW
Daniel Satgé
Under the concept of cancer immune surveillance, individuals with primary immune deficiencies would be expected to develop many more malignancies and show an excess of all types of cancers, compared to people with a normal immune system. A review of the nine most frequent and best-documented human conditions with primary immune deficiency reveals a 1.6- to 2.3-fold global increase of cancer in the largest epidemiological studies. However, the spectrum of cancer types with higher frequencies is narrow, limited mainly to lymphoma, digestive tract cancers, and virus-induced cancers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29880438/identification-management-and-transition-of-care-for-patients-with-opioid-use-disorder-in-the-emergency-department
#13
REVIEW
Herbert C Duber, Isabel A Barata, Eric Cioè-Peña, Stephen Y Liang, Eric Ketcham, Wendy Macias-Konstantopoulos, Shawn A Ryan, Mark Stavros, Lauren K Whiteside
Because of a soaring number of opioid-related deaths during the past decade, opioid use disorder has become a prominent issue in both the scientific literature and lay press. Although most of the focus within the emergency medicine community has been on opioid prescribing-specifically, on reducing the incidence of opioid prescribing and examining alternative pain treatment-interest is heightening in identifying and managing patients with opioid use disorder in an effective and evidence-based manner. In this clinical review article, we examine current strategies for identifying patients with opioid use disorder, the treatment of patients with acute opioid withdrawal syndrome, approaches to medication-assisted therapy, and the transition of patients with opioid use disorder from the emergency department to outpatient services...
June 4, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29879957/a-new-age-in-aquamedicine-unconventional-approach-in-studying-aquatic-diseases
#14
REVIEW
Michael Gotesman, Simon Menanteau-Ledouble, Mona Saleh, Sven M Bergmann, Mansour El-Matbouli
BACKGROUND: Marine and aquaculture industries are important sectors of the food production and global trade. Unfortunately, the fish food industry is challenged with a plethora of infectious pathogens. The freshwater and marine fish communities are rapidly incorporating novel and most up to date techniques for detection, characterization and treatment strategies. Rapid detection of infectious diseases is important in preventing large disease outbreaks. MAIN TEXT: One hundred forty-six articles including reviews papers were analyzed and their conclusions evaluated in the present paper...
June 8, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29879248/a-biologically-based-approach-to-acne-and-rosacea
#15
Penelope J Kallis, Alexandra Price, Jacquelyn R Dosal, Anna J Nichols, Jonette Keri
Complementary and alternative medicine (CAM) therapies are increasing in popularity in the field of dermatology. Natural products and holistic approaches are in high demand among patients and research has begun to support their roles in acne and rosacea pathophysiology. In this article, commonly utilized biologically based complementary and alternative therapies for acne and rosacea are reviewed from an evidence-based perspective. Therapies discussed include vitamin C, nicotinamide, zinc, tea tree oil, green tea, resveratrol, curcumin, feverfew, licorice, chamomile, polypodium leucotomos, and nutrition-based approaches...
June 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29875754/recent-progress-in-the-chemical-synthesis-of-class-ii-and-s-glycosylated-bacteriocins
#16
REVIEW
François Bédard, Eric Biron
A wide variety of antimicrobial peptides produced by lactic acid bacteria (LAB) have been identified and studied in the last decades. Known as bacteriocins, these ribosomally synthesized peptides inhibit the growth of a wide range of bacterial species through numerous mechanisms and show a great variety of spectrum of activity. With their great potential as antimicrobial additives and alternatives to traditional antibiotics in food preservation and handling, animal production and in veterinary and medical medicine, the demand for bacteriocins is rapidly increasing...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29872744/effects-of-the-gut-microbiota-on-amygdalin-and-its-use-as-an-anti-cancer-therapy-substantial-review-on-the-key-components-involved-in-altering-dose-efficacy-and-toxicity
#17
REVIEW
Vani Jaswal, Jeyanthi Palanivelu, Ramalingam C
Conventional and Alternative Medicine (CAM) is popularly used due to side-effects and failure of approved methods, for diseases like Epilepsy and Cancer. Amygdalin, a cyanogenic diglycoside is commonly administered for cancer with other CAM therapies like vitamins and seeds of fruits like apricots and bitter almonds, due to its ability to hydrolyse to hydrogen cyanide (HCN), benzaldehyde and glucose. Over the years, several cases of cyanide toxicity on ingestion have been documented. In-vitro and in-vivo studies using various doses and modes of administration, like IV administration studies that showed no HCN formation, point to the role played by the gut microbiota for the commonly seen poisoning on consumption...
July 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29870458/consensus-guidelines-on-the-use-of-intravenous-ketamine-infusions-for-chronic-pain-from-the-american-society-of-regional-anesthesia-and-pain-medicine-the-american-academy-of-pain-medicine-and-the-american-society-of-anesthesiologists
#18
Steven P Cohen, Anuj Bhatia, Asokumar Buvanendran, Eric S Schwenk, Ajay D Wasan, Robert W Hurley, Eugene R Viscusi, Samer Narouze, Fred N Davis, Elspeth C Ritchie, Timothy R Lubenow, William M Hooten
BACKGROUND: Over the past 2 decades, the use of intravenous ketamine infusions as a treatment for chronic pain has increased dramatically, with wide variation in patient selection, dosing, and monitoring. This has led to a chorus of calls from various sources for the development of consensus guidelines. METHODS: In November 2016, the charge for developing consensus guidelines was approved by the boards of directors of the American Society of Regional Anesthesia and Pain Medicine and, shortly thereafter, the American Academy of Pain Medicine...
June 7, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29869031/engineered-c-s-bond-construction
#19
REVIEW
Chin-Fa Lee, R Sidick Basha, Satpal Singh Badsara
Due to the versatile applications of thioethers and thioesters in organic synthesis, medicinal chemistry, the pharmaceutical industry, and materials science, recently the construction of C-S bonds has emerged as the forefront in the field of cross-coupling reactions. Enough progress has been made in this direction by using both metal catalysis and other alternative processes. A brief review of the recent developments in the area of C-S coupling reaction is described.
June 4, 2018: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/29868550/reverse-screening-methods-to-search-for-the-protein-targets-of-chemopreventive-compounds
#20
REVIEW
Hongbin Huang, Guigui Zhang, Yuquan Zhou, Chenru Lin, Suling Chen, Yutong Lin, Shangkang Mai, Zunnan Huang
This article is a systematic review of reverse screening methods used to search for the protein targets of chemopreventive compounds or drugs. Typical chemopreventive compounds include components of traditional Chinese medicine, natural compounds and Food and Drug Administration (FDA)-approved drugs. Such compounds are somewhat selective but are predisposed to bind multiple protein targets distributed throughout diverse signaling pathways in human cells. In contrast to conventional virtual screening, which identifies the ligands of a targeted protein from a compound database, reverse screening is used to identify the potential targets or unintended targets of a given compound from a large number of receptors by examining their known ligands or crystal structures...
2018: Frontiers in Chemistry
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