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3D Tomosynthesis

Ravi K Samala, Heang-Ping Chan, Lubomir Hadjiiski, Mark A Helvie, Jun Wei, Kenny Cha
PURPOSE: Develop a computer-aided detection (CAD) system for masses in digital breast tomosynthesis (DBT) volume using a deep convolutional neural network (DCNN) with transfer learning from mammograms. METHODS: A data set containing 2282 digitized film and digital mammograms and 324 DBT volumes were collected with IRB approval. The mass of interest on the images was marked by an experienced breast radiologist as reference standard. The data set was partitioned into a training set (2282 mammograms with 2461 masses and 230 DBT views with 228 masses) and an independent test set (94 DBT views with 89 masses)...
December 2016: Medical Physics
Nehmat Houssami, Robin M Turner
High breast tissue density increases breast cancer (BC) risk, and the risk of an interval BC in mammography screening. Density-tailored screening has mostly used adjunct imaging to screen women with dense breasts, however, the emergence of tomosynthesis (3D-mammography) provides an opportunity to steer density-tailored screening in new directions potentially obviating the need for adjunct imaging. A rapid review (a streamlined evidence synthesis) was performed to summarise data on tomosynthesis screening in women with heterogeneously dense or extremely dense breasts, with the aim of estimating incremental (additional) BC detection attributed to tomosynthesis in comparison with standard 2D-mammography...
December 2016: Breast: Official Journal of the European Society of Mastology
Richard E Sharpe, Shambavi Venkataraman, Jordana Phillips, Vandana Dialani, Valerie J Fein-Zachary, Seema Prakash, Priscilla J Slanetz, Tejas S Mehta
No abstract text is available yet for this article.
September 2016: Radiology
Jarno van Roosmalen, Marlies C Goorden, Freek J Beekman
Planar molecular breast imaging (MBI) is rapidly gaining in popularity in diagnostic oncology. To add 3D capabilities, we introduce a novel molecular breast tomosynthesis (MBT) scanner concept based on multi-pinhole collimation. In our design, the patient lies prone with the pendant breast lightly compressed between transparent plates. Integrated webcams view the breast through these plates and allow the operator to designate the scan volume (e.g. a whole breast or a suspected region). The breast is then scanned by translating focusing multi-pinhole plates and NaI(Tl) gamma detectors together in a sequence that optimizes count yield from the volume-of-interest...
August 7, 2016: Physics in Medicine and Biology
David A P Dunkerley, Tobias Funk, Michael A Speidel
Scanning-beam digital x-ray (SBDX) is an inverse geometry x-ray fluoroscopy system capable of tomosynthesis-based 3D catheter tracking. This work proposes a method of dose-reduced 3D tracking using dynamic electronic collimation (DEC) of the SBDX scanning x-ray tube. Positions in the 2D focal spot array are selectively activated to create a region-of-interest (ROI) x-ray field around the tracked catheter. The ROI position is updated for each frame based on a motion vector calculated from the two most recent 3D tracking results...
February 27, 2016: Proceedings of SPIE
Jordan M Slagowski, David A P Dunkerley, Charles R Hatt, Michael A Speidel
Accurate and artifact free reconstruction of tomographic images requires precise knowledge of the imaging system geometry. This work proposes a novel projection matrix (P-matrix) based calibration method to enable C-arm inverse geometry CT (IGCT). The method is evaluated for scanning-beam digital x-ray (SBDX), a C-arm mounted inverse geometry fluoroscopic technology. A helical configuration of fiducials is imaged at each gantry angle in a rotational acquisition. For each gantry angle, digital tomosynthesis is performed at multiple planes and a composite image analogous to a cone-beam projection is generated from the plane stack...
February 27, 2016: Proceedings of SPIE
Daniela Bernardi, Petra Macaskill, Marco Pellegrini, Marvi Valentini, Carmine Fantò, Livio Ostillio, Paolina Tuttobene, Andrea Luparia, Nehmat Houssami
BACKGROUND: Breast tomosynthesis (pseudo-3D mammography) improves breast cancer detection when added to 2D mammography. In this study, we examined whether integrating 3D mammography with either standard 2D mammography acquisitions or with synthetic 2D images (reconstructed from 3D mammography) would detect more cases of breast cancer than 2D mammography alone, to potentially reduce the radiation burden from the combination of 2D plus 3D acquisitions. METHODS: The Screening with Tomosynthesis Or standard Mammography-2 (STORM-2) study was a prospective population-based screening study comparing integrated 3D mammography (dual-acquisition 2D-3D mammography or 2D synthetic-3D mammography) with 2D mammography alone...
August 2016: Lancet Oncology
Willi A Kalender, Daniel Kolditz, Christian Steiding, Veikko Ruth, Ferdinand Lück, Ann-Christin Rößler, Evelyn Wenkel
: X-ray computed tomography (CT) has been proposed and evaluated multiple times as a potentially alternative method for breast imaging. All efforts shown so far have been criticized and partly disapproved because of their limited spatial resolution and higher patient dose when compared to mammography. Our concept for a dedicated breast CT (BCT) scanner therefore aimed at novel apparatus and detector design to provide high spatial resolution of about 100 μm and average glandular dose (AGD) levels of 5 mGy or below...
June 15, 2016: European Radiology
N Oliveira, A M Mota, N Matela, L Janeiro, P Almeida
BACKGROUND AND OBJECTIVES: A major challenge in Digital Breast Tomosynthesis (DBT) is handling image noise since the 3D reconstructed images are obtained from low dose projections and limited angular range. The use of the iterative reconstruction algorithm Algebraic Reconstruction Technique (ART) in clinical context depends on two key factors: the number of iterations needed (time consuming) and the image noise after iterations. Both factors depend highly on a relaxation coefficient (λ), which may give rise to slow or noisy reconstructions, when a single λ value is considered for the entire iterative process...
August 2016: Computer Methods and Programs in Biomedicine
Ji-Wook Jeong, Seung-Hoon Chae, Eun Young Chae, Hak Hee Kim, Young-Wook Choi, Sooyeul Lee
We propose computer-aided detection (CADe) algorithm for microcalcification (MC) clusters in reconstructed digital breast tomosynthesis (DBT) images. The algorithm consists of prescreening, MC detection, clustering, and false-positive (FP) reduction steps. The DBT images containing the MC-like objects were enhanced by a multiscale Hessian-based three-dimensional (3D) objectness response function and a connected-component segmentation method was applied to extract the cluster seed objects as potential clustering centers of MCs...
2016: BioMed Research International
Robert Hodgson, Sylvia H Heywang-Köbrunner, Susan C Harvey, Mary Edwards, Javed Shaikh, Mick Arber, Julie Glanville
This review investigated the relative performance of digital breast tomosynthesis (DBT) (alone or with full field digital mammography (FFDM) or synthetic digital mammography) compared with FFDM alone for detecting breast cancer lesions in asymptomatic women. A systematic review was carried out according to systematic reviewing principles provided in the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. A protocol was developed a priori. The review was registered with PROSPERO (number CRD42014013949)...
June 2016: Breast: Official Journal of the European Society of Mastology
Jeffrey S Nelson, Jered R Wells, Jay A Baker, Ehsan Samei
PURPOSE: The FDA approved the use of digital breast tomosynthesis (DBT) in 2011 as an adjunct to 2D full field digital mammography (FFDM) with the constraint that all DBT acquisitions must be paired with a 2D image to assure adequate interpretative information is provided. Recently manufacturers have developed methods to provide a synthesized 2D image generated from the DBT data with the hope of sparing patients the radiation exposure from the FFDM acquisition. While this much needed alternative effectively reduces the total radiation burden, differences in image quality must also be considered...
May 2016: Medical Physics
Pengpeng Zhang, Laura Happersett, Bosky Ravindranath, Michael Zelefsky, Gig Mageras, Margie Hunt
PURPOSE: Robust detection of implanted fiducials is essential for monitoring intrafractional motion during hypofractionated treatment. The authors developed a plan optimization strategy to ensure clear visibility of implanted fiducials and facilitate 3D localization during volumetric modulated arc therapy (VMAT). METHODS: Periodic kilovoltage (kV) images were acquired at 20° gantry intervals and paired with simultaneously acquired 4.4° short arc megavoltage digital tomosynthesis (MV-DTS) to localize three fiducials during VMAT delivery for hypofractionated prostate cancer treatment...
May 2016: Medical Physics
Nehmat Houssami
No abstract text is available yet for this article.
June 2016: Expert Review of Medical Devices
Margie A Hunt, Mark Sonnick, Hai Pham, Rajesh Regmi, Jian-ping Xiong, Daniel Morf, Gig S Mageras, Michael Zelefsky, Pengpeng Zhang
The purpose of this study was to evaluate the accuracy and clinical feasibility of a motion monitoring method employing simultaneously acquired MV and kV images during volumetric-modulated arc therapy (VMAT). Short-arc digital tomosynthesis (SA-DTS) is used to improve the quality of the MV images that are then combined with orthogonally acquired kV images to assess 3D motion. An anthropomorphic phantom with implanted gold seeds was used to assess accuracy of the method under static, typical prostatic, and respiratory motion scenarios...
2016: Journal of Applied Clinical Medical Physics
Lynda Ikejimba, Joseph Y Lo, Yicheng Chen, Nadia Oberhofer, Nooshin Kiarashi, Ehsan Samei
PURPOSE: In medical imaging systems, proper rendition of anatomy is essential in discerning normal tissue from disease. Currently, digital breast tomosynthesis (DBT) systems are evaluated using subjective evaluation of lesion visibility in uniform phantoms. This study involved the development of a new methodology to objectively measure the rendition of a 3D breast model by an anthropomorphic breast phantom, and its implementation on five clinical DBT systems of different makes and models...
April 2016: Medical Physics
Nehmat Houssami, Kristina Lång, Daniela Bernardi, Alberto Tagliafico, Sophia Zackrisson, Per Skaane
This pictorial review highlights cancers detected only at tomosynthesis screening and screens falsely recalled in the course of breast tomosynthesis screening, illustrating both true-positive (TP) and false-positive (FP) detection attributed to tomosynthesis. Images and descriptive data were used to characterise cases of screen-detection with tomosynthesis, sourced from prospective screening trials that performed standard (2D) digital mammography (DM) and tomosynthesis (3D-mammography) in the same screening participants...
April 2016: Breast: Official Journal of the European Society of Mastology
Mayuresh Kulkarni, Ronald Dendere, Fred Nicolls, Tania S Douglas
BACKGROUND: Digital breast tomosynthesis (DBT) reconstructs planar slices of the breast based on two-dimensional angular projections. Early studies and clinical trials show that DBT is an improvement over full field digital mammography (FFDM) because it provides the radiologist with better image quality and more information. OBJECTIVE: This paper presents a simulation system to model the performance of a slot-scanning FFDM and DBT system. METHODS: A tissue-equivalent three dimensional (3D) breast phantom was constructed, validated for slot-scanning digital mammography and used in simulating digital breast tomosynthesis...
2016: Journal of X-ray Science and Technology
Howard C Gifford, Zhihua Liang, Mini Das
PURPOSE: Mathematical model observers commonly used for diagnostic image-quality assessments in x-ray imaging research are generally constrained to relatively simple detection tasks due to their need for statistical prior information. Visual-search (VS) model observers that employ morphological features in sequential search and analysis stages have less need for such information and fewer task constraints. The authors compared four VS observers against human observers and an existing scanning model observer in a pilot study that quantified how mass detection and localization in simulated digital breast tomosynthesis (DBT) can be affected by the number P of acquired projections...
March 2016: Medical Physics
Kelly E Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Steven P Poplack, Andrew Karellas, Brian W Pogue, Keith D Paulsen
Calibration of a three-dimensional multimodal digital breast tomosynthesis (DBT) x-ray and non-fiber based near infrared spectral tomography (NIRST) system is challenging but essential for clinical studies. Phantom imaging results yielded linear contrast recovery of total hemoglobin (HbT) concentration for cylindrical inclusions of 15 mm, 10 mm and 7 mm with a 3.5% decrease in the HbT estimate for each 1 cm increase in inclusion depth. A clinical exam of a patient's breast containing both benign and malignant lesions was successfully imaged, with greater HbT was found in the malignancy relative to the benign abnormality and fibroglandular regions (11 μM vs...
December 1, 2015: Biomedical Optics Express
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