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https://www.readbyqxmd.com/read/28654959/cardiovascular-testing-and-clinical-outcomes-in-emergency-department-patients-with-chest-pain
#1
Alexander T Sandhu, Paul A Heidenreich, Jay Bhattacharya, M Kate Bundorf
Importance: Noninvasive testing and coronary angiography are used to evaluate patients who present to the emergency department (ED) with chest pain, but their effects on outcomes are uncertain. Objective: To determine whether cardiovascular testing-noninvasive imaging or coronary angiography-is associated with changes in the rates of coronary revascularization or acute myocardial infarction (AMI) admission in patients who present to the ED with chest pain without initial findings of ischemia...
June 26, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28654880/fine-particulate-air-pollution-and-hospital-visits-for-asthma-in-beijing-china
#2
Yaohua Tian, Xiao Xiang, Juan Juan, Kexin Sun, Jing Song, Yaying Cao, Yonghua Hu
Data on fine particulate matter (PM2.5) in China were first announced in 2013. The primary objective of this study was to evaluate the acute effects of PM2.5 on asthma morbidity in Beijing, China. A total of 978,658 asthma hospital visits consisting of 928,607 outpatient visits, 40,063 emergency room visits and 9988 hospital admissions from January 1, 2010, to June 30, 2012, were identified from the Beijing Medical Claim Data for Employees. A generalized additive Poisson model was applied to explore the association between PM2...
June 24, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28654679/increased-risk-of-thyroid-diseases-in-patients-with-systemic-lupus-erythematosus-a-nationwide-population-based-study-in-korea
#3
Jae-Seung Yun, Jung Min Bae, Ki-Jo Kim, Yu Seok Jung, Gyong Moon Kim, Hyung-Rae Kim, Jun-Seok Lee, Seung-Hyun Ko, Seon-Ah Cha, Yu-Bae Ahn
We investigated the association between autoimmune thyroid disease and systemic lupus erythematosus (SLE) using nationwide insurance claims data for the entire Korean population. Claims data for the period 2009-2013 were retrieved from the National Health Insurance System database. SLE and thyroid disease were identified using the International Classification of Diseases codes and medication information. Logistic regression analyses were used to evaluate the association between SLE and thyroid disease. The study used records from 17,495 patients with SLE and 52,485 age- and sex-matched control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28654675/estimating-the-disease-burden-of-methicillin-resistant-staphylococcus-aureus-in-japan-retrospective-database-study-of-japanese-hospitals
#4
Hironori Uematsu, Kazuto Yamashita, Susumu Kunisawa, Kiyohide Fushimi, Yuichi Imanaka
OBJECTIVES: The nationwide impact of antimicrobial-resistant infections on healthcare facilities throughout Japan has yet to be examined. This study aimed to estimate the disease burden of methicillin-resistant Staphylococcus aureus (MRSA) infections in Japanese hospitals. DESIGN: Retrospective analysis of inpatients comparing outcomes between subjects with and without MRSA infection. DATA SOURCE: A nationwide administrative claims database...
2017: PloS One
https://www.readbyqxmd.com/read/28654483/therapy-use-for-children-with-developmental-conditions-analysis-of-colorado-medicaid-data
#5
Beth M McManus, Mary Jane Rapport, Zachary Richardson, Richard Lindrooth
STUDY PURPOSE: To examine therapy use and spending for Medicaid-enrolled infants and toddlers with developmental conditions. METHODS: Sample infants and toddlers had a diagnosis (eg, cerebral palsy) or developmental delay (DD). Colorado Children's Medicaid administrative outpatient therapy claims (2006-2008) were used to estimate differences, by condition type and number of comorbid chronic conditions (CCCs), of any physical therapy (PT)/occupational therapy (OT) and Medicaid PT/OT spending...
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654210/do-plant-eating-insect-lineages-pass-through-phases-of-host-use-generalism-during-speciation-and-host-switching-phylogenetic-evidence
#6
Nate B Hardy
The Oscillation Hypothesis posits that plant-eating insect diversity is generated by cycles of diet breadth expansion and contraction. Although at any given time most plant-eating insect species are host specialists, host use evolution and speciation tend to entail a phase of generalism. The main evidence for this comes from comparative phylogenetic studies, but with mixed support. Here, I review and add to this evidence. I show that some of the original work that inspired the Oscillation Hypothesis is flawed in a way that leads to spurious inferences about trends in the evolution of diet diversity...
June 27, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28654203/effects-of-storage-temperature-on-bacterial-growth-rates-and-community-structure-in-fresh-retail-sushi
#7
Sunniva Hoel, Anita Nordeng Jakobsen, Olav Vadstein
AIMS: This study was conducted to assess the effects of different storage temperatures (4 to 20 °C), on bacterial concentrations, growth rates and community structure in fresh retail sushi, a popular retail product with a claimed shelf life of two to three days. METHODS AND RESULTS: The maximum specific growth rate based on aerobic plate count (APC) at 4 °C was 0.06 h(-1) , and displayed a 6-fold increase (0.37 h(-1) ) at 20 °C. Refrigeration resulted in no growth of hydrogen sulfide (H2 S)-producing bacteria, but this group had the strongest temperature response...
June 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28653000/updates-in-mirizzi-syndrome
#8
REVIEW
Alan Isaac Valderrama-Treviño, Juan José Granados-Romero, Mariana Espejel-Deloiza, Jonathan Chernitzky-Camaño, Baltazar Barrera Mera, Aranza Guadalupe Estrada-Mata, Jesús Carlos Ceballos-Villalva, Jonathan Acuña Campos, Rubén Argüero-Sánchez
Mirizzi syndrome, known as extrinsic bile compression syndrome, is a rare complication of cholecystitis and chronic cholelithiasis, secondary to the obliteration of the infundibulum of the gallbladder or cystic duct caused by the impact of one or more calculations in these anatomical structures, which leads to compression of the adjacent bile duct, resulting in partial or complete obstruction of the common hepatic duct, triggering liver dysfunction. Our aim is to identify and describe the current epidemiology, diagnostic methods, and treatment of Mirizzi syndrome...
June 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28652712/medication-related-issues-associated-with-adherence-to-long-term-tyrosine-kinase-inhibitors-for-controlling-chronic-myeloid-leukemia-a-qualitative-study
#9
Bee Kim Tan, Seng Beng Tan, Li-Chia Chen, Kian Meng Chang, Siew Siang Chua, Sharmini Balashanker, Habiba Nazeera Begum Kamarul Jaman, Syed Carlo Edmund, Ping Chong Bee
PURPOSE: Poor adherence to tyrosine kinase inhibitors (TKIs) could compromise the control of chronic myeloid leukemia (CML) and contributes to poorer survival. Little is known about how medication-related issues affect CML patients' adherence to TKI therapy in Malaysia. This qualitative study aimed to explore these issues. PATIENTS AND METHODS: Individual face-to-face, semistructured interviews were conducted at the hematology outpatient clinics of two medical centers in Malaysia from August 2015 to January 2016...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28652459/blood-pressure-antihypertensive-polypharmacy-frailty-and-risk-for-serious-fall-injuries-among-older-treated-adults-with-hypertension
#10
Samantha G Bromfield, Cedric-Anthony Ngameni, Lisandro D Colantonio, C Barrett Bowling, Daichi Shimbo, Kristi Reynolds, Monika M Safford, Maciej Banach, Peter P Toth, Paul Muntner
Antihypertensive medication and low systolic blood pressure (BP) and diastolic BP have been associated with an increased falls risk in some studies. Many older adults have indicators of frailty, which may increase their risk for falls. We contrasted the association of systolic BP, diastolic BP, number of antihypertensive medication classes taken, and indicators of frailty with risk for serious fall injuries among 5236 REGARDS study (Reasons for Geographic and Racial Difference in Stroke) participants ≥65 years taking antihypertensive medication at baseline with Medicare fee-for-service coverage...
June 26, 2017: Hypertension
https://www.readbyqxmd.com/read/28652320/trends-in-utilization-of-warfarin-and-direct-oral-anticoagulants-in-older-adult-patients-with-atrial-fibrillation
#11
Abdullah A Alalwan, Stacy A Voils, Abraham G Hartzema
PURPOSE: Results of a study to determine trends in oral anticoagulant (OAC) use and OAC switching in patients with atrial fibrillation (AF) or atrial flutter are presented. METHODS: Warfarin has been the most prescribed anticoagulant in patients with AF for decades. Since 2010, several direct OACs (DOACs) have gained U.S. marketing approval for stroke prevention in AF or atrial flutter. A cross-sectional longitudinal analysis was conducted using healthcare and prescription claims databases to characterize OAC use and rates of OAC and DOAC switching during the period 2008-14 in cohorts of Medicare beneficiaries 65 years of age or older with AF or atrial flutter...
June 26, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28652016/overall-effectiveness-of-rivaroxaban-in-patients-with-pulmonary-embolism
#12
Li Wang, Onur Baser, Phil Wells, W Frank Peacock, Craig I Coleman, Gregory J Fermann, Jeff Schein, Concetta Crivera
PURPOSE: Due to limited evidence on the impact of rivaroxaban in clinical practice, we compared the effectiveness of rivaroxaban versus standard of care (SOC) among patients in the Veterans Health Administration. METHODS: Adult patients with continuous enrollment in a health plan with medical and pharmacy benefits for ≥12 months before and ≥3 months after an inpatient diagnosis of pulmonary embolism (PE) between October 1, 2011, and June 30, 2015, and a prescription claim for an anticoagulant during the index hospitalization, were included...
June 23, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28651825/prescription-patterns-and-costs-of-acne-rosacea-medications-in-medicare-patients-vary-by-prescriber-specialty
#13
Myron Zhang, Jonathan I Silverberg, Benjamin H Kaffenberger
BACKGROUND: Prescription patterns for acne/rosacea medications have not been described in the Medicare population, and comparisons across specialties are lacking. OBJECTIVE: To describe the medications used for treating acne/rosacea in the Medicare population and evaluate differences in costs between specialties. METHODS: A cross-sectional study was performed of the 2008 and 2010 Centers for Medicare and Medicaid Services Prescription Drug Profiles, which contains 100% of Medicare part D claims...
June 23, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28651575/ontological-interpretation-of-biomedical-database-content
#14
Filipe Santana da Silva, Ludger Jansen, Fred Freitas, Stefan Schulz
BACKGROUND: Biological databases store data about laboratory experiments, together with semantic annotations, in order to support data aggregation and retrieval. The exact meaning of such annotations in the context of a database record is often ambiguous. We address this problem by grounding implicit and explicit database content in a formal-ontological framework. METHODS: By using a typical extract from the databases UniProt and Ensembl, annotated with content from GO, PR, ChEBI and NCBI Taxonomy, we created four ontological models (in OWL), which generate explicit, distinct interpretations under the BioTopLite2 (BTL2) upper-level ontology...
June 26, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28651554/validation-of-an-international-classification-of-disease-ninth-revision-coding-algorithm-to-identify-decompressive-craniectomy-for-stroke
#15
Hormuzdiyar H Dasenbrock, David J Cote, Yuri Pompeu, Viren S Vasudeva, Timothy R Smith, William B Gormley
BACKGROUND: Although International Classification of Disease, Ninth Revision, Clinical Modification (ICD9-CM) coding is the basis of administrative claims data, no study has validated an ICD9-CM algorithm to identify patients undergoing decompressive craniectomy for space-occupying supratentorial infarction. METHODS: Patients who underwent decompressive craniectomy for stroke at our institution were retrospectively identified and their associated ICD9-CM codes were extracted from billing data...
June 26, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28651322/ozonation-of-tannic-acid-to-model-biomass-pretreatment-for-bioethanol-production
#16
Roi Peretz, Yoram Gerchman, Hadas Mamane
Lignocellulosic biomass is a promising feedstock for ethanol production, but lignin, a polyphenol, hampers the use of enzymes for its saccharification; pretreatment is thus key to preparing such feedstock. Ozonation was previously demonstrated as an effective pretreatment, but claimed to be uneconomical due to the assumed need for lignin mineralization. We analyzed, for the first time, ozonation of highly concentrated tannic acid (TA) solution (60g/L) as a lignin model. Most of the TA disappeared within 3.5h, following triple-phase kinetics with two transition points: at 7min and 60min of ozonation for 0...
June 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28651053/hexafluorophosphate-based-solutions-for-mg-batteries-and-the-importance-of-chlorides
#17
Ivgeni Shterenberg, Michael Salama, Yosef Gofer, Doron Aurbach
The selection of viable conventional magnesium salts in electrolyte solutions for Mg secondary batteries is very limited. Reversible magnesium deposition was only demonstrated with MgTFSI2, in ethereal solutions. A recent report has suggested that Mg can be reversibly deposited from a solution of Mg(PF6)2 in THF and acetonitrile. In this paper, we dispute that claim and show that PF6(-) anions passivate Mg anodes and completely inhibit any Mg deposition/dissolution process. We show that addition of chlorides suppresses the passivation phenomena and allows for reversible Mg deposition/dissolution processes to commence...
June 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28650923/the-effect-of-false-positive-mammograms-on-antidepressant-and-anxiolytic-initiation
#18
Joel E Segel, Rajesh Balkrishnan, Richard A Hirth
BACKGROUND: Despite reported increases in anxiety following a false-positive mammogram, there is little evidence the effect rises to the clinical level of initiating medication. OBJECTIVE: To analyze the effect of a false-positive mammogram on antidepressant or anxiolytic initiation and identify subpopulations most at risk. SUBJECTS: MarketScan commercial and Medicaid claims databases used to identify women ages 40-64 undergoing screening mammography with no prior antidepressant or anxiolytic claims...
June 23, 2017: Medical Care
https://www.readbyqxmd.com/read/28650922/randomized-trial-of-reducing-ambulatory-malpractice-and-safety-risk-results-of-the-massachusetts-promises-project
#19
Gordon D Schiff, Harry Reyes Nieva, Paula Griswold, Nicholas Leydon, Judy Ling, Frank Federico, Carol Keohane, Bonnie R Ellis, Cathy Foskett, E John Orav, Catherine Yoon, Don Goldmann, Joel S Weissman, David W Bates, Madeleine Biondolillo, Sara J Singer
OBJECTIVE: Evaluate application of quality improvement approaches to key ambulatory malpractice risk and safety areas. STUDY SETTING: In total, 25 small-to-medium-sized primary care practices (16 intervention; 9 control) in Massachusetts. STUDY DESIGN: Controlled trial of a 15-month intervention including exposure to a learning network, webinars, face-to-face meetings, and coaching by improvement advisors targeting "3+1" high-risk domains: test result, referral, and medication management plus culture/communication issues evaluated by survey and chart review tools...
June 23, 2017: Medical Care
https://www.readbyqxmd.com/read/28650921/effect-of-continuity-of-care-on-drug-drug-interactions
#20
Jiun-Yu Guo, Yiing-Jenq Chou, Christy Pu
BACKGROUND: Drug-drug interaction (DDI) is a critical concern in health care systems because it is directly associated with patient outcomes and is generally preventable. However, few studies have been conducted on whether poor continuity of care (COC) is a determinant of DDIs and whether this effect varies by level of comorbidity. Patients with higher comorbidity normally require more complex treatment regimens than other patients, and hence their COC is more critical for ensuring the accuracy of their medication information...
June 23, 2017: Medical Care
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