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https://www.readbyqxmd.com/read/28944733/performance-based-risk-sharing-arrangements-for-pharmaceutical-products-in-the-united-states-a-systematic-review
#1
Justin S Yu, Lauren Chin, Jennifer Oh, Jorge Farias
BACKGROUND: Value for money is a growing necessity in today's U.S. health care system in which drug spending is expected to increase by an average rate of 6.7% yearly through 2025. In response to uncertainty about real-world clinical and economic outcomes for many drugs, health insurers and pharmacy benefit managers (PBMs) have implemented various contracts and arrangements with drug manufacturers that can collectively be described as performance-based risk-sharing arrangements (PBRSAs)...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944728/performance-based-risk-sharing-arrangements-u-s-payer-experience
#2
Joseph A Goble, Brian Ung, Sascha van Boemmel-Wegmann, Robert P Navarro, Andrew Parece
BACKGROUND: As a result of global concern about rising drug costs, many U.S. payers and European agencies such as the National Health Service have partnered with pharmaceutical companies in performance-based risk-sharing arrangements (PBRSAs) by which manufacturers share financial risk with health care purchasing entities and authorities. However, PBRSAs present many administrative and legal challenges that have minimized successful contract experiences in the United States. OBJECTIVE: To (a) identify drug and disease characteristics and contract components that contribute to successful PBRSA experiences and the primary barriers to PBRSA execution and (b) explore solutions to facilitate contract negotiation and execution...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944537/pharmacologic-management-of-voice-disorders-by-general-medicine-providers-and-otolaryngologists
#3
Seth M Cohen, Hui-Jie Lee, Nelson Roy, Stephanie Misono
OBJECTIVES: 1) To compare laryngeal diagnoses from general medical providers (GMP) to otolaryngologists following GMP-based medication trial, and 2) to evaluate associations between GMP medication trials and pharmacologic treatment by otolaryngologists. METHODS: Retrospective cohort analysis using large, national administrative U.S. claims database. Patients with laryngeal/voice disorders as per the International Classification of Diseases, Ninth Revision, Clinical Modification codes from January 1, 2010, to December 31, 2012, seen by a GMP and then an otolaryngologist between 2 weeks to 3 months after the GMP visit, were included...
September 25, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28944511/cost-utility-analysis-of-direct-vad-versus-double-bridges-to-heart-transplantation-in-patients-with-refractory-heart-failure
#4
Hsiao-Huang Chang, Po-Lin Chen, I-Ming Chen, Tzu-Ting Kuo, Zen-Chung Weng, Pei-Jung Huang, Nai-Yuan Wu, Ching-Li Cheng
OBJECT: This study compared the cost-utility of direct ventricular assist device (VAD) versus double bridges, extracorporeal membrane oxygenation (ECMO) before VAD, to heart transplantation in patients with refractory heart failure. MATERIALS AND METHODS: From a health payer perspective, a Markov model was developed. The cycle length was one month and the time horizon was a lifetime. Probabilities and direct cost data were calculated from a nationwide claim database...
September 25, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28944071/prevalence-and-screening-for-anaemia-in-mild-to-moderate-crohn-s-disease-and-ulcerative-colitis-in-the-united-states-2010-2014
#5
Eboselume Akhuemonkhan, Alyssa Parian, Kay Miller, Stephen Hanauer, Susan Hutfless
BACKGROUND AND AIMS: Anaemia affects up to 74% patients with Crohn's disease (CD) and ulcerative colitis (UC) and is correlated with decreased quality of life. The European Crohn's and Colitis Organisation (ECCO) recommends at least annual screening for iron-deficiency anaemia. We aimed to determine the prevalence of anaemia, frequency of anaemia screening and factors associated with anaemia in a retrospective study of mild to moderate inflammatory bowel disease (IBD) in the USA. METHODS: Adults with at least two outpatient encounters for IBD between 2010 through 2014 who contributed laboratory information were identified from MarketScan, a US commercial claims database...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28943976/is-empiricism-empirically-false-lessons-from-early-nervous-systems
#6
Marcin Miłkowski
Recent work on skin-brain thesis (de Wiljes et al. 2015; Keijzer 2015; Keijzer et al. 2013) suggests the possibility of empirical evidence that empiricism is false. It implies that early animals need no traditional sensory receptors to be engaged in cognitive activity. The neural structure required to coordinate extensive sheets of contractile tissue for motility provides the starting point for a new multicellular organized form of sensing. Moving a body by muscle contraction provides the basis for a multicellular organization that is sensitive to external surface structure at the scale of the animal body...
2017: Biosemiotics
https://www.readbyqxmd.com/read/28943969/the-right-to-know-and-the-right-not-to-know-revisited-part-one
#7
Roger Brownsword, Jeff Wale
Prompted by developments in human genetics, a recurrent bioethical question concerns a person's 'right to know' and 'right not to know' about genetic information held that is intrinsically related to or linked to them. In this paper, we will revisit the claimed rights in relation to two particular test cases. One concerns the rights of the 500,000 participants in UK Biobank (UKB) whose biosamples, already having been genotyped, will now be exome sequenced, and the other concerns the rights of pregnant women (and their children) who undergo non-invasive prenatal testing (NIPT)-a simple blood test that can reveal genetic information about both a foetus and its mother...
2017: Asian Bioeth Rev
https://www.readbyqxmd.com/read/28943210/technical-aspects-of-preparing-peg-plga-nanoparticles-as-carrier-for-chemotherapeutic-%C3%A2-agents-by-nanoprecipitation-method
#8
REVIEW
Hassan A Almoustafa, Mohammed A Alshawsh, Zamri Chik
Nanoprecipitation is a simple and increasingly trending method for nanoparticles preparation. The self-assembly feature of poly (ethylene glycol)-poly (lactide-co-glycolic acid) (PEG-PLGA) amphiphilic copolymer into a nanoparticle and its versatile structure makes nanoprecipitation one of the best methods for its preparation. The aim of this study is to review currently available literature for standard preparation of PEG-PLGA nanoparticles using nanoprecipitation technique in order to draw conclusive evidenceto draw conclusive evidence that can guide researchers during formulation development...
September 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28942775/missed-diagnosis-of-cardiovascular-disease-in-outpatient-general-medicine-insights-from-malpractice-claims-data
#9
Gene R Quinn, Darrell Ranum, Ellen Song, Margarita Linets, Carol Keohane, Heather Riah, Penny Greenberg
BACKGROUND: Diagnostic errors are an underrecognized source of patient harm, and cardiovascular disease can be challenging to diagnose in the ambulatory setting. Although malpractice data can inform diagnostic error reduction efforts, no studies have examined outpatient cardiovascular malpractice cases in depth. A study was conducted to examine the characteristics of outpatient cardiovascular malpractice cases brought against general medicine practitioners. METHODS: Some 3,407 closed malpractice claims were analyzed in outpatient general medicine from CRICO Strategies' Comparative Benchmarking System database-the largest detailed database of paid and unpaid malpractice in the world-and multivariate models were created to determine the factors that predicted case outcomes...
October 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28942701/feeding-tubes-and-health-care-service-utilization-in-amyotrophic-lateral-sclerosis-benefits-and-limits-to-a-retrospective-multicenter-study-using-big-data
#10
Keith M Swetz, Stephanie M Peterson, Lindsey R Sangaralingham, Ryan T Hurt, Shannon M Dunlay, Nilay D Shah, Jon C Tilburt
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurologic disorder with predictable challenges regarding disease progression and end-of-life care. These include need for respiratory and nutritional support. Little is known about how such choices impact end-of-life health service utilization for these patients. Using OptumLabs Data Warehouse, a large administrative claims database with more than 150 million privately insured, geographically diverse enrollees, we sought to explore outcomes associated with the use of enteral nutrition (EN)...
January 1, 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28942418/clinical-trial-transparency-a-reassessment-of-industry-compliance-with-clinical-trial-registration-and-reporting-requirements-in-the-united-states
#11
Scott M Lassman, Olivia M Shopshear, Ina Jazic, Jocelyn Ulrich, Jeffrey Francer
OBJECTIVE: To evaluate the accuracy of a 2015 cross-sectional analysis published in the BMJ Open which reported that pharmaceutical industry compliance with clinical trial registration and results reporting requirements under US law was suboptimal and varied widely among companies. DESIGN: We performed a reassessment of the data reported in Miller et al to evaluate whether statutory compliance analyses and conclusions were valid. DATA SOURCES: Information from the Dryad Digital Repository, ClinicalTrials...
September 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28942090/improving-risk-equalization-for-individuals-with-persistently-high-costs-experiences-from-the-netherlands
#12
Frank Eijkenaar, René C J A van Vliet
BACKGROUND: Risk-equalization (RE) models in competitive health insurance markets have become increasingly sophisticated. However, these models still have important imperfections. A specific problem in the Netherlands is that insurers are insufficiently compensated for individuals who can persistently be found in the right-end tail of the cost distribution. OBJECTIVES: The goal of this study is to explore and evaluate options for improving compensation for persistently high-cost individuals in the Dutch basic health insurance...
September 14, 2017: Health Policy
https://www.readbyqxmd.com/read/28942041/quality-of-life-following-road-traffic-injury-a-systematic-literature-review
#13
Ritva Rissanen, Hans-Yngve Berg, Marie Hasselberg
PURPOSE: To assess and provide a systematic overview of current knowledge about the relationship between quality of life (QoL) and road traffic injury, and to appraise how QoL is affected by road traffic injury. METHODS: A systematic review of the literature published since 1990 on QoL after a road traffic injury, including adult and paediatric populations, from three databases (Pubmed, PsychInfo and SafetyLit) was undertaken. The methodological quality was assessed according to the Newcastle-Ottawa Quality Assessment Scale...
September 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28941673/influence-of-package-and-health-related-claims-on-perception-and-sensory-acceptability-of-snack-bars
#14
Vinícius Rodrigues Arruda Pinto, Tamara Beatriz de Oliveira Freitas, Maria Inês de Souza Dantas, Suzana Maria Della Lucia, Laura Fernandes Melo, Valéria Paula Rodrigues Minim, Josefina Bressan
Concerns for health can lead to healthier food choices, especially if the consumer is well informed. This study aimed to evaluate the importance of package and health-related claims on Brazilian consumers' acceptance of snack bars. In order to evaluate package attributes, in focus groups discussions, 19 consumers chose the most important factors that influence their purchase decisions. Next, 102 consumers evaluated six commercial brands of snack bars in a three-session acceptance test: the first with no information about the product, the second containing the product package and the third with information on health-related claims associated with consumption of the bar...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28941671/outcomes-of-emergency-department-anaphylaxis-visits-from-2005-to-2014
#15
Megan S Motosue, M Fernanda Bellolio, Holly K Van Houten, Nilay D Shah, James T Li, Ronna L Campbell
BACKGROUND: Although the incidence of anaphylaxis appears to be increasing, trends in anaphylaxis-related health care utilization are not well understood. OBJECTIVE: To better understand the potential increasing health care burden, we analyzed the changes in anaphylaxis-related health care utilization, including emergency department (ED) discharges, observation stays, inpatient admissions, intensive care unit admissions, and endotracheal intubations. METHODS: We conducted an observational study examining outcomes of anaphylaxis-related ED visits between January 1, 2005, and December 31, 2014...
September 20, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28941554/an-evaluation-of-dental-antibiotic-prescribing-practices-in-the-united-states
#16
Michael J Durkin, Kevin Hsueh, Ya Haddy Sallah, Qianxi Feng, S Reza Jafarzadeh, Kiraat D Munshi, Peter B Lockhart, Martin H Thornhill, Rochelle R Henderson, Victoria J Fraser
BACKGROUND: Antibiotic prescribing practices among general dentists and dental specialists in the United States remains poorly understood. The purpose of this study was to compare prescribing practices across dental specialties, evaluate the duration of antibiotics dentists prescribed, and determine variation in antibiotic selection among dentists. METHODS: The authors performed a retrospective cross-sectional analysis of dental care provider specialties linked to deidentified antibiotic claims data from a large pharmacy benefits manager during the 2015 calendar year...
September 16, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28941007/leveraging-population-based-clinical-quantitative-phenotyping-for-drug-repositioning
#17
Adam S Brown, Danielle Rasooly, Chirag J Patel
Computational drug repositioning methods can scalably nominate approved drugs for new diseases, with reduced risk of unforeseen side effects. The majority of methods eschew individual-level phenotypes despite the promise of biomarker-driven repositioning. In this study, we propose a framework for discovering serendipitous interactions between drugs and routine clinical phenotypes in cross-sectional observational studies. Key to our strategy is the use of a healthy and non-diabetic population derived from the National Health and Nutrition Examination Survey, mitigating risk for confounding by indication...
September 22, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28940605/adjuvant-chemotherapy-after-radical-nephroureterectomy-does-not-improve-survival-in-patients-with-upper-tract-urothelial-carcinoma-a-joint-study-of-the-eau-young-academic-urologists-and-the-upper-tract-urothelial-carcinoma-collaboration
#18
Andrea Necchi, Salvatore Lo Vullo, Luigi Mariani, Marco Moschini, Kees Hendricksen, Michael Rink, Roman Sosnowski, Jakub Dobruch, Jay D Raman, Christopher G Wood, Vitaly Margulis, Morgan Roupret, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat
OBJECTIVE: To analyze the outcomes of adjuvant chemotherapy versus observation in a multicenter cohort of patients with upper tract urothelial carcinoma (UTUC). The benefit from adjuvant chemotherapy after radical nephroureterectomy (RNU) is debated in these patients. PATIENTS AND METHODS: Data from 15 centers was collected, totalling 1,544 patients, treated between 2000 and 2015. Criteria for patient selection included pT2-4N0/x stage, or lymph node-positive disease, and prior RNU...
September 20, 2017: BJU International
https://www.readbyqxmd.com/read/28940547/incidence-prevalence-and-mortality-of-adamantiades-beh%C3%A3-et-s-disease-in-korea-a-nationwide-population-based-study-2006-2015
#19
Y B Lee, S Y Lee, J Y Choi, J H Lee, H S Chae, J W Kim, K D Han, Y G Park, D S Yu
BACKGROUND: The epidemiology of Adamantiades-Behçet's disease varies among ethnic populations worldwide. Trends in the incidence of Adamantiades-Behçet's disease have not been investigated based on the Korean National Health Insurance database. OBJECTIVES: This study investigated the incidence and mortality of Adamantiades-Behçet's disease by age using nationwide population data in Korea. METHODS: A nationwide population-based cohort study was performed using the Korean National Health Insurance Claims Database from 2006 to 2015...
September 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28940537/spending-per-medicare-beneficiary-is-higher-in-hospital-owned-small-and-medium-sized-physician-practices
#20
Michael F Pesko, Andrew M Ryan, Stephen M Shortell, Kennon R Copeland, Patricia P Ramsay, Xuming Sun, Jayme L Mendelsohn, Diane R Rittenhouse, Lawrence P Casalino
OBJECTIVE: To examine the relationship of physician versus hospital ownership of small- and medium-sized practices with spending and utilization of care. DATA SOURCE/STUDY SETTING/DATA COLLECTION: Survey data for 1,045 primary care-based practices of 1-19 physicians linked to Medicare claims data for 2008 for 282,372 beneficiaries attributed to the 3,010 physicians in these practices. STUDY DESIGN: We used generalized linear models to estimate the associations between practice characteristics and outcomes (emergency department visits, index admissions, readmissions, and spending)...
September 21, 2017: Health Services Research
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