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https://www.readbyqxmd.com/read/29353097/genetics-of-immunoglobulin-a-vasculitis-henoch-sch%C3%A3-nlein-purpura-an-updated-review
#1
REVIEW
Raquel López-Mejías, Santos Castañeda, Fernanda Genre, Sara Remuzgo-Martínez, F David Carmona, Javier Llorca, Ricardo Blanco, Javier Martín, Miguel A González-Gay
Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood vessel vasculitis with predominant involvement of the skin. Gastrointestinal and joint manifestations are common in patients diagnosed with this condition. Nephritis, which is more severe in adults, constitutes the most feared complication of this vasculitis. The molecular bases underlying the origin of IgAV have not been completely elucidated. Nevertheless, several pieces of evidence support the claim that genes play a crucial role in the pathogenesis of this disease...
January 15, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29352592/development-and-validation-of-an-icd-10-based-disability-predictive-index-for-patients-admitted-to-hospitals-with-trauma
#2
Tomoki Wada, Hideo Yasunaga, Hayato Yamana, Hiroki Matsui, Kiyohide Fushimi, Naoto Morimura
BACKGROUND: There was no established disability predictive measurement for patients with trauma that could be used in administrative claims databases. The aim of the present study was to develop and validate a diagnosis-based disability predictive index for severe physical disability at discharge using the International Classification of Diseases, 10th revision (ICD-10) coding. METHODS: This retrospective observational study used the Diagnosis Procedure Combination database in Japan...
December 28, 2017: Injury
https://www.readbyqxmd.com/read/29352271/sex-disparity-in-cancer-roles-of-micrornas-and-related-functional-players
#3
REVIEW
Alessandra Carè, Maria Bellenghi, Paola Matarrese, Lucia Gabriele, Stefano Salvioli, Walter Malorni
A sexual dimorphism at the cellular level has been suggested to play a role in cancer onset and progression. In particular, very recent studies have unraveled striking differences between cells carrying XX or XY chromosomes in terms of response to stressful stimuli, indicating the presence of genetic and epigenetic differences determining sex-specific metabolic or phenotypic traits. Although this field of investigation is still in its infancy, available data suggest a key role of sexual chromosomes in determining cell life or death...
January 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29351845/a-precise-cdk-activity-threshold-determines-passage-through-the-restriction-point
#4
Clayton Schwarz, Amy Johnson, Mardo Kõivomägi, Evgeny Zatulovskiy, Carolyn J Kravitz, Andreas Doncic, Jan M Skotheim
At the restriction point (R), mammalian cells irreversibly commit to divide. R has been viewed as a point in G1 that is passed when growth factor signaling initiates a positive feedback loop of Cdk activity. However, recent studies have cast doubt on this model by claiming R occurs prior to positive feedback activation in G1 or even before completion of the previous cell cycle. Here we reconcile these results and show that whereas many commonly used cell lines do not exhibit a G1 R, primary fibroblasts have a G1 R that is defined by a precise Cdk activity threshold and the activation of cell-cycle-dependent transcription...
January 18, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29351751/social-determinants-of-male-health-a-case-study-of-leeds-uk
#5
Alan White, Amanda Seims, Ian Cameron, Tim Taylor
BACKGROUND: The social determinants of health have a disproportionate impact on mortality in men. A study into the state of health of the male population in Leeds was undertaken to guide public health commissioning decisions. This paper reports on the data relating to the social lives of men. METHODS: A cross-sectional study was undertaken, comprising descriptive analysis of data relating to educational attainment, housing, employment (including benefit claimants), marital status and relationships...
January 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29351665/swiss-consumers-willingness-to-pay-and-attitudes-regarding-dual-purpose-poultry-and-eggs
#6
I D M Gangnat, S Mueller, M Kreuzer, R E Messikommer, M Siegrist, V H M Visschers
Chick culling is an efficient and cost-effective method in modern poultry farming, but it raises ethical concerns. Dual-purpose poultry (DP), in which males are fattened and females are used for egg production, is currently the most realistic alternative to culling, as in ovo sexing is not yet viable for practical application. Consumers' acceptance of DP products and their willingness to pay (WTP) for them have not been studied yet, and we expect that both aspects are closely related to the acceptance of and WTP for products from systems claiming beyond-conventional animal welfare, such as organic products...
January 17, 2018: Poultry Science
https://www.readbyqxmd.com/read/29351547/mortality-and-continuity-of-care-definitions-matter-a-cohort-study-in-diabetics
#7
Angelika Geroldinger, Simone Katja Sauter, Georg Heinze, Gottfried Endel, Wolfgang Dorda, Georg Duftschmid
OBJECTIVE: To demonstrate that when investigating the relevance of continuity of care for patient outcomes, different definitions can lead to contradicting results. METHODS: We used claims data from the regional public health insurer of Lower Austria covering the period from 2008 to 2011. The study sample included subjects with repeated dispensings of anti-diabetic drugs. The continuity of care index was calculated firstly based on a patient's contacts with general practitioners (primary COCI) and secondly based on contacts at all medical disciplines (total COCI)...
2018: PloS One
https://www.readbyqxmd.com/read/29351319/speech-stone-tool-making-and-the-evolution-of-language
#8
Dana Michelle Cataldo, Andrea Bamberg Migliano, Lucio Vinicius
The 'technological hypothesis' proposes that gestural language evolved in early hominins to enable the cultural transmission of stone tool-making skills, with speech appearing later in response to the complex lithic industries of more recent hominins. However, no flintknapping study has assessed the efficiency of speech alone (unassisted by gesture) as a tool-making transmission aid. Here we show that subjects instructed by speech alone underperform in stone tool-making experiments in comparison to subjects instructed through either gesture alone or 'full language' (gesture plus speech), and also report lower satisfaction with their received instruction...
2018: PloS One
https://www.readbyqxmd.com/read/29351183/the-effect-of-impactful-papers-on-clinical-practice-in-the-us-corticosteroid-injection-for-patients-with-lateral-epicondylitis
#9
Yuki Fujihara, Helen E Huetteman, Ting-Ting Chung, Melissa J Shauver, Kevin C Chung
BACKGROUND: Following the publication of high level evidence demonstrating that corticosteroid inject is not an effective treatment for lateral epicondylitis, a reduction in the rate of corticosteroid injection would be expected. We aimed to clarify the current clinical practice pattern for lateral epicondylitis and to identify which factors hinder or encourage the introduction of evidence into clinical practice. METHODS: In this administrative claims analysis, we used the 2009 to 2015 Truven MarketScan databases...
January 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29350634/mri-of-popliteo-meniscal-fasciculi-of-the-knee-a-pictorial-review
#10
Marcello Zappia, Alfonso Reginelli, Vito Chianca, Michela Carfora, Francesco Di Pietto, Germano Iannella, Pier Paolo Mariani, Mariano Di Salvatore, Silvia Bartollino, Nicola Maggialetti, Salvatore Cappabianca, Luca Brunese
The popliteomeniscal fascicules (PMFs) provide the attachment of the lateral meniscus to the popliteus musculotendinous region, forming the floor and the roof the popliteal hiatus. In the second half of 1900's, some anatomic studies claim the important function of the PMF as stabilizers of the lateral meniscus; these anatomical structures work in conjunction with the popliteus musculotendinous unit to prevent excessive lateral meniscal movement and possible meniscus subluxation. A correct diagnosis of the PMFs pathology is crucial to establish the suitable surgical treatment for each patient...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350558/synbiotics-for-improved-human-health-recent-developments-challenges-and-opportunities
#11
Janina A Krumbeck, Jens Walter, Robert W Hutkins
Research on combining pro- and prebiotics as synbiotics to enhance human and animal health has accelerated in the past 10 years, including many clinical trials that have assessed a diverse range of synbiotic formulations. In this review, we summarize these studies as well as the commercial applications of synbiotics that are available. In particular, we critically assess the claimed health benefits of synbiotic applications and the ecological and therapeutic factors to consider when designing synbiotics and discuss the implications of these concepts for future research in this fiel Expected final online publication date for the Annual Review of Food Science and Technology Volume 9 is March 25, 2018...
January 18, 2018: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/29350507/hospital-participation-in-meaningful-use-and-racial-disparities-in-readmissions
#12
Mark Aaron Unruh, Hye Young Jung, Rainu Kaushal, Joshua R Vest
OBJECTIVES: To measure the impact of hospital participation in Meaningful Use (MU) on disparities in 30-day readmissions associated with race. STUDY DESIGN: A retrospective cohort study that compared the likelihood of 30-day readmission for Medicare beneficiaries discharged from hospitals participating in Stage 1 of MU with the likelihood of readmission for beneficiaries concurrently discharged from hospitals that were not participating in the initiative. METHODS: Inpatient claims for 2,414,205 Medicare beneficiaries from Florida, New York, and Washington State were used as the primary data source...
January 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29350073/in-their-own-words-a-synthesis-of-the-qualitative-research-on-the-experiences-of-adults-seeking-asylum-a-systematic-review-of-qualitative-findings-in-forced-migration
#13
Thomas Hoare, Andrew Vidgen, Neil Roberts
Quantitative research indicates that some forced migrants have mental health needs. Asylum seekers are a group of forced migrants applying for asylum status in a host country, and are often subject to rights restrictions and threat of deportation, though little is known about subjective experiences of the asylum journey and process of claiming asylum. The current paper therefore describes a systematic review of the qualitative literature, examining asylum seekers experiences of asylum journey, from country of origin, to arrival and adaptation to host countries...
December 2017: Medicine, Conflict, and Survival
https://www.readbyqxmd.com/read/29349921/community-pharmacists-views-on-the-regulation-of-complementary-medicines-and-complementary-medicines-practitioners-a-qualitative-study-in-new-zealand
#14
Joanne Barnes, Rachael Butler
OBJECTIVES: To examine community pharmacists' perspectives on CMs regulation in New Zealand, where proposals for CMs regulations had recently been suspended and where, currently, CMs are only weakly regulated. METHODS: Qualitative, in-depth, semi-structured interviews with New Zealand practising community pharmacists are identified through purposive and convenience sampling. Data were analysed using a general inductive approach. KEY FINDINGS: Participants held mixed views regarding harmonisation of CMs regulations across Australia and NZ; some supported an NZ national regulatory framework for CMs, based on the Australian system...
January 19, 2018: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29349781/mirror-neurons-and-intention-understanding-dissociating-the-contribution-of-object-type-and-intention-to-mirror-responses-using-electromyography
#15
Maura Ruggiero, Caroline Catmur
Since their discovery in the monkey and human brain, mirror neurons have been claimed to play a key role in understanding others' intentions. For example, "action-constrained" mirror neurons in inferior parietal lobule fire when the monkey observes a grasping movement that is followed by an eating action, but not when it is followed by a placing action. It is claimed these responses enable the monkey to predict the intentions of the actor. These findings have been replicated in human observers by recording electromyography responses of the mouth-opening mylohyoid muscle during action observation...
January 18, 2018: Psychophysiology
https://www.readbyqxmd.com/read/29348602/the-ten-year-evolutionary-trajectory-of-a-highly-recurrent-paediatric-high-grade-neuroepithelial-tumour-with-mn1-bend2-fusion
#16
Anna Burford, Alan Mackay, Sergey Popov, Maria Vinci, Diana Carvalho, Matthew Clarke, Elisa Izquierdo, Aimee Avery, Thomas S Jacques, Wendy J Ingram, Andrew S Moore, Kieran Frawley, Timothy E Hassall, Thomas Robertson, Chris Jones
Astroblastomas are rare brain tumours which predominate in children and young adults, and have a controversial claim as a distinct entity, with no established WHO grade. Reports suggest a better outcome than high grade gliomas, though they frequently recur. Recently, they have been described to overlap with a newly-discovered group of tumours described as'high grade neuroepithelial tumour with MN1 alteration' (CNS HGNET-MN1), defined by global methylation patterns and strongly associated with gene fusions targeting MN1...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348096/antiulcer-activity-of-methanol-chloroform-extract-of-channa-striatus-fillet
#17
Ahmad Khusairi Azemi, Mohd Hafiz Abd Rahim, Siti Syariah Mamat, Abdul Manan Mat Jais, Zainul Amiruddin Zakaria
Channa striatus (Haruan) is Malaysian freshwater fish that is traditionally used to treat ailments related to wound and also ulcers. The aimed of the present study was to determine the mechanisms of anti-ulcer activity of chloroform: methanol extract of C. striatus fillet (CMCS) in rats. The antiulcer profile of CMCS, given orally in the doses of 50, 250 and 500mg/kg, was assessed using the ethanol- and indomethacin-induced gastric ulcer models. The mechanisms of antiulcer of CMCS were determined as follows; i) the antisecretory activity of CMCS was measured using the pyloric ligation rat model, and; ii) the role of nitric oxide (NO) and sulfhydryl compounds in the modulation of CMCS antiulcer activity were determined by pre-treating the rats with L-NAME or NEM, respectively, followed by the pre-treatment of rats with CMCS before subjecting the animals to the ethanol-induced gastric ulcer model...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29347952/the-german-quality-network-sepsis-study-protocol-for-the-evaluation-of-a-quality-collaborative-on-decreasing-sepsis-related-mortality-in-a-quasi-experimental-difference-in-differences-design
#18
Daniel Schwarzkopf, Hendrik Rüddel, Matthias Gründling, Christian Putensen, Konrad Reinhart
BACKGROUND: While sepsis-related mortality decreased substantially in other developed countries, mortality of severe sepsis remained as high as 44% in Germany. A recent German cluster randomized trial was not able to improve guideline adherence and decrease sepsis-related mortality within the participating hospitals, partly based on lacking support by hospital management and lacking resources for documentation of prospective data. Thus, more pragmatic approaches are needed to improve quality of sepsis care in Germany...
January 18, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29347922/characteristics-of-individuals-receiving-disability-benefits-in-the-netherlands-and-predictors-of-leaving-the-disability-benefit-scheme-a-retrospective-cohort-study-with-five-year-follow-up
#19
Ilse Louwerse, Maaike A Huysmans, H Jolanda van Rijssen, Allard J van der Beek, Johannes R Anema
BACKGROUND: Today, work disability is one of the greatest social and labour market challenges for policy makers in most OECD countries, where on average, about 6% of the working-age population relies on disability benefits. Understanding of factors associated with long-term work disability may be helpful to identify groups of individuals at risk for disability benefit entitlement or continuing eligibility, and to develop effective interventions for these groups. The purpose of this study is to provide insight into the main diagnoses of workers who qualify for disability benefits and how these diagnoses differ in age, gender and education...
January 18, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29347725/partition-function-zeros-of-the-p-state-clock-model-in-the-complex-temperature-plane
#20
Dong-Hee Kim
We investigate the partition function zeros of the two-dimensional p-state clock model in the complex temperature plane by using the Wang-Landau method. For p=5, 6, 8, and 10, we propose a modified energy representation to enumerate exact irregular energy levels for the density of states without any binning artifacts. Comparing the leading zeros between different p's, we provide strong evidence that the upper transition at p=6 is indeed of the Berezinskii-Kosterlitz-Thouless (BKT) type in contrast to the claim of the previous Fisher zero study [Phys...
November 2017: Physical Review. E
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