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https://www.readbyqxmd.com/read/27926725/an-update-on-obtaining-and-enforcing-therapeutic-antibody-patent-claims
#1
Theresa Gresl, Ulrich Storz, Colin Sandercock
No abstract text is available yet for this article.
December 7, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27926663/the-impact-of-value-based-healthcare-for-inflammatory-bowel-diseases-on-healthcare-utilization-a-pilot-study
#2
Welmoed K van Deen, Arlen Spiro, A Burak Ozbay, Martha Skup, Adriana Centeno, Natalie E Duran, Precious N Lacey, Darius Jatulis, Eric Esrailian, Martijn G H van Oijen, Daniel W Hommes
BACKGROUND AND OBJECTIVES: Value-based healthcare (VBHC) is considered to be the solution that will improve quality and decrease costs in healthcare. Many hospitals are implementing programs on the basis of this strategy, but rigorous scientific reports are still lacking. In this pilot study, we present the first-year outcomes of a VBHC program for inflammatory bowel disease (IBD) management that focuses on highly coordinated care, task differentiation of providers, and continuous home monitoring...
December 6, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27926652/hysteroscopic-sterilization-with-essure-summary-of-the-u-s-food-and-drug-administration-actions-and-policy-implications-for-postmarketing-surveillance
#3
Jessica R Walter, Comeron W Ghobadi, Emily Hayman, Shuai Xu
In September 2015, the U.S. Food and Drug Administration (FDA) convened a meeting of the Obstetrics and Gynecology Advisory Board Committee to address the sudden increase of patient-reported adverse events surrounding Essure, a Class III device offering a less invasive method for permanent female sterilization. After a review of the premarketing and postmarketing data and existing scientific literature, the FDA concluded there was insufficient evidence to remove the device from the market. However, the FDA did release a new guidance document requiring a black box warning for the device and ordered a new postmarketing study comparing Essure's safety and efficacy with laparoscopic tubal sterilization...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926644/cervical-cancer-screening-guideline-adherence-before-and-after-guideline-changes-in-pennsylvania-medicaid
#4
Natasha Parekh, Julie M Donohue, Aiju Men, Jennifer Corbelli, Marian Jarlenski
OBJECTIVE: To assess changes in cervical cancer screening after the 2009 American College of Obstetricians and Gynecologists' guideline change and to determine predictors associated with underscreening and overscreening among Medicaid-enrolled women. METHODS: We performed an observational cohort study of Pennsylvania Medicaid claims from 2007 to 2013. We evaluated guideline adherence of 18- to 64-year-old continuously enrolled women before and after the 2009 guideline change...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926639/angiotensin-converting-enzyme-inhibitors-and-the-risk-of-congenital-malformations
#5
Brian T Bateman, Elisabetta Patorno, Rishi J Desai, Ellen W Seely, Helen Mogun, Sara Z Dejene, Michael A Fischer, Alexander M Friedman, Sonia Hernandez-Diaz, Krista F Huybrechts
OBJECTIVE: To examine the association between first-trimester angiotensin-converting enzyme (ACE) inhibitor exposure and the risk of overall major congenital, cardiac, and central nervous system malformations. METHODS: We used a cohort of completed pregnancies linked to liveborn neonates derived from Medicaid claims from 2000 to 2010. We examined the risk of malformations associated with first-trimester exposure to an ACE inhibitor. Propensity score-based methods were used to control for potential confounders including maternal demographics, medical conditions, exposure to other medications, and measures of health care utilization...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926558/postoperative-venous-thromboembolism-in-patients-undergoing-abdominal-surgery-for-ibd-a-common-but-rarely-addressed-problem
#6
Matthew T Brady, Gregory J Patts, Amy Rosen, George Kasotakis, Jeffrey J Siracuse, Teviah Sachs, Angela Kuhnen, Hiroko Kunitake
BACKGROUND: Venous thromboembolism after abdominal surgery occurs in 2% to 3% of patients with Crohn's disease and ulcerative colitis. However, no evidence-based guidelines currently exist to guide postdischarge prophylactic anticoagulation. OBJECTIVE: We sought to determine the use of postoperative postdischarge venous thromboembolism chemical prophylaxis, 90-day venous thromboembolism rates, and factors associated with 90-day thromboembolic events in IBD patients following abdominal surgery...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27926380/out-of-hours-workload-management-bayesian-inference-for-decision-support-in-secondary-care
#7
Iker Perez, Michael Brown, James Pinchin, Sarah Martindale, Sarah Sharples, Dominick Shaw, John Blakey
OBJECTIVE: In this paper, we aim to evaluate the use of electronic technologies in out of hours (OoH) task-management for assisting the design of effective support systems in health care; targeting local facilities, wards or specific working groups. In addition, we seek to draw and validate conclusions with relevance to a frequently revised service, subject to increasing pressures. METHODS AND MATERIAL: We have analysed 4 years of digitised demand-data extracted from a recently deployed electronic task-management system, within the Hospital at Night setting in two jointly coordinated hospitals in the United Kingdom...
October 2016: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/27925639/outcomes-following-arthroscopic-repair-of-posterior-labral-tears-in-patients-older-than-35-years
#8
Dexter K Bateman, Eric M Black, Mark D Lazarus, Joseph A Abboud
Although the results of arthroscopic management of posterior labral pathology in young athletes have been reported extensively in the literature, the clinical outcomes in older patients are unknown. This retrospective review included patients older than 35 years who underwent arthroscopic posterior labral repair. Functional outcome scores were collected, and subgroup analyses were performed to evaluate the impact of patient-specific factors. Forty-three patients met the inclusion criteria; average follow-up was 36...
December 7, 2016: Orthopedics
https://www.readbyqxmd.com/read/27925596/investigating-echo-state-networks-dynamics-by-means-of-recurrence-analysis
#9
Filippo Maria Bianchi, Lorenzo Livi, Cesare Alippi
In this paper, we elaborate over the well-known interpretability issue in echo-state networks (ESNs). The idea is to investigate the dynamics of reservoir neurons with time-series analysis techniques developed in complex systems research. Notably, we analyze time series of neuron activations with recurrence plots (RPs) and recurrence quantification analysis (RQA), which permit to visualize and characterize high-dimensional dynamical systems. We show that this approach is useful in a number of ways. First, the 2-D representation offered by RPs provides a visualization of the high-dimensional reservoir dynamics...
December 2, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27925109/analysis-of-factors-associated-with-traffic-accidents-of-cyclists-attended-in-brazilian-state-capitals
#10
Carlos Augusto Moreira de Sousa, Camila Alves Bahia, Patrícia Constantino
Introduction: Brazil has the sixth largest bicycles fleet in the world and bicycle is the most used individual transport vehicle in the country. Few studies address the issue of cyclists' accidents and factors that contribute to or prevent this event. Methodology: VIVA is a cross-sectional survey and is part of the Violence and Accidents Surveillance System, Brazilian Ministry of Health. We used complex sampling and subsequent data review through multivariate logistic regression and calculation of the respective odds ratios...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925092/everyday-representations-of-young-people-about-peripheral-areas
#11
Elda de Oliveira, Cassia Baldini Soares, Leandro Leonardo Batista
Objectives: to understand everyday representations of young people about the peripheral areas, with the purpose of establishing topics to drug education media programs. Method: Marxist approach, with emancipatory action research and the participation in workshops of 13 youngsters from a public school of the peripheral area of São Paulo. Results: there are contradictory everyday representations about the State's role, which, on the one hand, does not guarantee social rights and exert social control over the peripheral areas and, on the other hand, is considered the privileged interlocutor for the improvement of life and work conditions...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27925017/community-health-workers-perceptions-in-relation-to-speech-and-language-disorders
#12
Carla Cristina Lins Santos Knochenhauer, Karina Mary de Paiva Vianna
Purpose: To know the perception of the Community Health Workers (CHW) about the speech and language disorders. Method: Cross-sectional study, which involved a questionnaire with questions related to the knowledge of CHW on speech and language disorders. The research was carried out with CHW allocated in the Centro Sanitary District of Florianópolis. Results: We interviewed 35 CHW, being mostly (80%) female gender, with a average age of 47 years (standard deviation = 2...
December 1, 2016: CoDAS
https://www.readbyqxmd.com/read/27924930/new-principle-for-measuring-arterial-blood-oxygenation-enabling-motion-robust-remote-monitoring
#13
Mark van Gastel, Sander Stuijk, Gerard de Haan
Finger-oximeters are ubiquitously used for patient monitoring in hospitals worldwide. Recently, remote measurement of arterial blood oxygenation (SpO2) with a camera has been demonstrated. Both contact and remote measurements, however, require the subject to remain static for accurate SpO2 values. This is due to the use of the common ratio-of-ratios measurement principle that measures the relative pulsatility at different wavelengths. Since the amplitudes are small, they are easily corrupted by motion-induced variations...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924446/educational-encounters-of-the-third-kind
#14
Gonzalo Génova, M Rosario González
An engineer who becomes an educator in a school of software engineering has the mission to teach how to design and construct software systems, therein applying his or her knowledge and expertise. However, due to their engineering background, engineers may forget that educating a person is not the same as designing a machine, since a machine has a well-defined goal, whilst a person is capable to self-propose his or her own objectives. The ethical implications are clear: educating a free person must leave space for creativity and self-determination in his or her own discovery of the way towards personal and professional fulfillment, which cannot consist only in achieving goals selected by others...
December 6, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27924437/disability-life-writing-and-the-problem-of-dependency-in-the-autobiography-of-gaby-brimmer
#15
Rachel Adams
Independence was a core value of the movement for disability rights. People with disabilities did not have to be dependent, advocates claimed; they were robbed of autonomy by poverty, social prejudice, and architectural barriers. Recently, critics have noted that the emphasis on independence equates personhood with autonomy, reason, and self-awareness, thereby excluding those who are incapable of self-determination. The stigma of dependency is communicated to caregivers whose work is devalued and undercompensated...
December 7, 2016: Journal of Medical Humanities
https://www.readbyqxmd.com/read/27924187/evaluating-outcomes-in-patients-with-overactive-bladder-within-an-integrated-healthcare-delivery-system-using-a-treatment-patterns-analyzer
#16
Daniel B Ng, Melissa McCart, Christopher Klein, Chelsey Campbell, Robert Schoenhaus, Todd Berner
BACKGROUND: Overactive bladder (OAB) is a relatively common disease that has been linked to a variety of comorbidities, reductions in quality of life, and increased healthcare costs. Antimuscarinic agents are the standard of care among pharmacologic treatments for OAB, but these drugs are linked to high levels of anticholinergic burden, especially in the elderly. OBJECTIVE: To demonstrate how efficient data analysis can be used to identify gaps in care as a result of improvement strategies for OAB within an integrated healthcare delivery system setting...
September 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27924186/treatment-of-chronic-hepatitis-c-infection-with-sofosbuvir-based-regimens-in-a-commercially-insured-patient-population
#17
John Barron, Yiqiong Xie, Sze-Jung Wu, Jeff White, Joseph Singer, Bernard Tulsi, Alan Rosenberg
BACKGROUND: The response to treatment with direct-acting antiviral agents in patients with chronic hepatitis C virus (HCV) is not well-characterized in the real-world setting. OBJECTIVE: To describe patients' response to 3 sofosbuvir-based treatment regimens among commercially insured patients with chronic HCV. METHODS: In this observational study, we identified patients with HCV who started sofosbuvir treatment with 1 of 3 sofosbuvir-based regimens between December 1, 2013, and April 30, 2014, in the HealthCore Integrated Research Database, a large managed care repository...
September 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27924050/timing-of-carotid-revascularization-procedures-after-ischemic-stroke
#18
Michael Reznik, Hooman Kamel, Gino Gialdini, Ankur Pandya, Babak B Navi, Ajay Gupta
BACKGROUND AND PURPOSE: In 2006, the American Heart Association recommended that carotid revascularization generally occurs within 2 weeks of stroke based on data from 2 trials of carotid endarterectomy (CEA). We aimed to determine whether the time between stroke and CEA or carotid artery stenting (CAS) has decreased and whether the proportion of procedures occurring within 14 days has increased. METHODS: Using validated International Classification of Diseases, Ninth Revision, Clinical Modification codes and administrative claims data from nonfederal hospitals in CA, FL, and NY, we identified patients with ischemic stroke who underwent CEA or CAS within 90 days of an ischemic stroke from 2005 to 2013...
December 6, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27923239/-motivational-and-volitional-determinants-of-applying-for-psychosomatic-rehabilitation-findings-of-a-cohort-study
#19
M Bethge, E Peters, E Michel, F M Radoschewski, K Spanier
Objective: Analyses of motivational and volitional determinants of applying for psychosomatic rehabilitation Methods: Determinants of a rehabilitation request were assessed by a questionnaire in 2013. Applications for psychosomatic rehabilitation measures until the end of 2014 were extracted from administrative data records. Included were employees with mental disorders. Results: Only 55 of 974 persons requested a rehabilitation measure. The intention to apply for a rehabilitation measure was strongest determined by self-efficacy and family and professional support...
December 2016: Die Rehabilitation
https://www.readbyqxmd.com/read/27923207/comparing-the-risks-of-hospitalized-heart-failure-associated-with-glinide-sulfonylurea-and-acarbose-use-in-type-2-diabetes-a-nationwide-study
#20
Yen-Chieh Lee, Chia-Hsuin Chang, Yaa-Hui Dong, Jou-Wei Lin, Li-Chiu Wu, Jing-Shiang Hwang, Lee-Ming Chuang
BACKGROUND: Increasing evidence suggests that certain newer anti-diabetic drugs are associated with an increased risk of hospitalized heart failure (HHF). However, the potential risks associated with the use of sulfonylurea and glinide have not been carefully evaluated. METHODS: A retrospective cohort study using the Taiwan National Health Insurance claims database was conducted to examine the risks of HHF among newly diagnosed type 2 diabetic patients who initiated glinide, sulfonylurea, or acarbose therapy during 2006-2012...
November 10, 2016: International Journal of Cardiology
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