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https://www.readbyqxmd.com/read/29793191/development-and-validation-of-a-prediction-model-for-functional-decline-in-older-medical-inpatients
#1
Toshihiko Takada, Shingo Fukuma, Yosuke Yamamoto, Yukio Tsugihashi, Hiroyuki Nagano, Michio Hayashi, Jun Miyashita, Teruhisa Azuma, Shunichi Fukuhara
OBJECTIVE: To prevent functional decline in older inpatients, identification of high-risk patients is crucial. The aim of this study was to develop and validate a prediction model to assess the risk of functional decline in older medical inpatients. METHODS: In this retrospective cohort study, patients ≥65 years admitted acutely to medical wards were included. The healthcare database of 246 acute care hospitals (n = 229,913) was used for derivation, and two acute care hospitals (n = 1767 and 5443, respectively) were used for validation...
May 17, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29793184/an-actigraphic-study-of-the-sleep-patterns-of-younger-and-older-school-age-children
#2
Reut Gruber, Gail Somerville, Samantha Wells, Deniz Keskinel, Jose Arturo Santisteban
OBJECTIVE: Sleep is viewed as being relatively consistent across the school-age period (6-13 years of age), however this claim has not been empirically supported. The objective of this study was to document the duration, schedule, variability, and week versus weekend discrepancies of sleep in three distinct age groups within the school-age period. METHODS: Participants were divided by age: Cycle 1, 6 and 7 years; Cycle 2, 8 and 9 years; and Cycle 3, 10 and 11 years...
April 10, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29793100/the-still-uncertain-identity-of-the-channel-forming-unit-s-of-the-mitochondrial-permeability-transition-pore
#3
REVIEW
Christopher P Baines, Manuel Gutiérrez-Aguilar
Mitochondria from different organisms can undergo a sudden process of inner membrane unselective leakiness to molecules known as the mitochondrial permeability transition (MPT). This process has been studied for nearly four decades and several proteins have been claimed to constitute, or at least regulate the usually inactive pore responsible for this transition. However, no protein candidate proposed as the actual pore-forming unit has passed rigorous gain- or loss-of-function genetic tests. Here we review evidence for -and against- putative channel-forming components of the MPT pore...
May 16, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29792737/assessing-the-recall-rate-for-screening-mammography-comparing-the-medicare-hospital-compare-dataset-with-the-national-mammography-database
#4
Cindy S Lee, Carol Parise, Judy Burleson, David Seidenwurm
OBJECTIVE: High-quality screening mammography has been shown to substantially reduce mortality from breast cancer. Recall rate is a principal performance metric for screening mammography because it directly relates to the rate of false-positive examinations. This study aims to compare the recall rate derived using two sources-the claims-based Hospital Compare (HC) dataset from the Centers for Medicare & Medicaid Services versus the National Mammography Database (NMD) from the American College of Radiology-to understand the implications in pay-for-performance and quality improvement activities...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792253/genocide-rape-trauma-a-conceptual-framework-for-understanding-the-psychological-suffering-of-rwandan-survivors
#5
Donatilla Mukamana, Anthony Collins, William E Rosa
In 1994, the Rwandan genocide claimed the lives of approximately 1 million Tutsi and moderate Hutu citizens. Systematic rape was a strategic component of the Hutu extremist plan to eradicate the Tutsi minority population. This involved collective and repeated sexual assaults with brutal violence, public humiliation, and torture. This article maps the ongoing psychological impact on Rwandan genocide rape survivors and identifies implications for international nursing practice. The research formalizes their narratives, identifying a number of interconnected elements that combine to produce myriad forms of chronic psychological suffering in the Rwandan context...
May 1, 2018: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/29792251/claiming-and-naming-your-seat-at-the-multiauthorship-table
#6
Diane B Monsivais
No abstract text is available yet for this article.
May 1, 2018: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/29792108/does-maximalist-footwear-lower-impact-loading-during-level-ground-and-downhill-running
#7
Zoe Y S Chan, Ivan P H Au, Fannie O Y Lau, Eric C K Ching, Janet H Zhang, Roy T H Cheung
A new model of running shoes which features an extreme cushioning and an oversized midsole, known as the maximalist (MAX) was launched. This design claims to provide excellent shock absorption, particularly during downhill running. This study sought to assess the effects of MAX on the external impact loading, footstrike pattern, and stride length during level ground and downhill running on an instrumented treadmill. Twenty-seven distance runners completed four 5-minute running trials in the two footwear conditions (MAX and traditional running shoes (TRS)) on a level surface (0%) and downhill (10%-declination)...
May 24, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29791271/language-skills-but-not-frequency-discrimination-predict-reading-skills-in-children-at-risk-of-dyslexia
#8
Margaret J Snowling, Debbie Gooch, Genevieve McArthur, Charles Hulme
This study evaluated the claim that auditory processing deficits are a cause of reading and language difficulties. We report a longitudinal study of 245 children at family risk of dyslexia, children with preschool language impairments, and control children. Children with language impairments had poorer frequency-discrimination thresholds than controls at 5.5 years, but children at family risk of dyslexia did not. A model assessing longitudinal relationships among frequency discrimination, reading, language, and executive function skills showed that frequency discrimination was predicted by executive skills but was not a longitudinal predictor of reading or language skills...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29791190/the-comprehensive-primary-care-initiative-effects-on-spending-quality-patients-and-physicians
#9
Deborah Peikes, Stacy Dale, Arkadipta Ghosh, Erin Fries Taylor, Kaylyn Swankoski, Ann S O'Malley, Timothy J Day, Nancy Duda, Pragya Singh, Grace Anglin, Laura L Sessums, Randall S Brown
The Comprehensive Primary Care Initiative (CPC), a health care delivery model developed by the Centers for Medicare and Medicaid Services (CMS), tested whether multipayer support of 502 primary care practices across the country would improve primary care delivery, improve care quality, or reduce spending. We evaluated the initiative's effects on care delivery and outcomes for fee-for-service Medicare beneficiaries attributed to initiative practices, relative to those attributed to matched comparison practices...
May 23, 2018: Health Affairs
https://www.readbyqxmd.com/read/29791188/the-effects-of-cognitive-and-visual-workload-on-peripheral-detection-in-the-detection-response-task
#10
Wim van Winsum
OBJECTIVE: The independent effects of cognitive and visual load on visual Detection Response Task (vDRT) reaction times were studied in a driving simulator by performing a backwards counting task and a simple driving task that required continuous focused visual attention to the forward view of the road. The study aimed to unravel the attentional processes underlying the Detection Response Task effects. BACKGROUND: The claim of previous studies that performance degradation on the vDRT is due to a general interference instead of visual tunneling was challenged in this experiment...
May 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29790265/lipid-lowering-medication-use-is-associated-with-decreased-risk-of-diabetic-retinopathy-and-its-treatments-in-patients-with-type-2-diabetes-a-real-world-observational-analysis-of-a-health-claims-database
#11
Ryo Kawasaki, Tsuneo Konta, Kohji Nishida
AIMS: Fenofibrate and statins reduced the risk of diabetic retinopathy (DR) related treatment in clinical trials. We aimed to determine whether lipid-lowering medication use reduce the risk of DR and its treatments in patients with type 2 diabetes using a real-world health claims database. METHODS: This was an observational analysis using a nation-wide health claims database of the Japan Medical Data Center (JMDC). Type 2 diabetes was defined by the ICD-10 codes with glucose-lowering medication use...
May 22, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29790166/physical-therapy-as-the-first-point-of-care-to-treat-low-back-pain-an-instrumental-variables-approach-to-estimate-impact-on-opioid-prescription-health-care-utilization-and-costs
#12
Bianca K Frogner, Kenneth Harwood, C Holly A Andrilla, Malaika Schwartz, Jesse M Pines
OBJECTIVE: To compare differences in opioid prescription, health care utilization, and costs among patients with low back pain (LBP) who saw a physical therapist (PT) at the first point of care, at any time during the episode or not at all. DATA SOURCES: Commercial health insurance claims data, 2009-2013. STUDY DESIGN: Retrospective analyses using two-stage residual inclusion instrumental variable models to estimate rates for opioid prescriptions, imaging services, emergency department visits, hospitalization, and health care costs...
May 23, 2018: Health Services Research
https://www.readbyqxmd.com/read/29790162/getting-what-we-pay-for-how-do-risk-based-payments-to-medicare-advantage-plans-compare-with-alternative-measures-of-beneficiary-health-risk
#13
Paul D Jacobs, Richard Kronick
OBJECTIVE: To estimate the relative health risk of Medicare Advantage (MA) beneficiaries compared to those in Traditional Medicare (TM). DATA SOURCES/STUDY SETTING: Medicare claims and enrollment records for the sample of beneficiaries enrolled in Part D between 2008 and 2015. STUDY DESIGN: We assigned therapeutic classes to Medicare beneficiaries based on their prescription drug utilization. We then regressed nondrug health spending for TM beneficiaries in 2015 on demographic and therapeutic class identifiers for 2014 and used coefficients from this regression to predict relative risk of both MA and TM beneficiaries...
May 22, 2018: Health Services Research
https://www.readbyqxmd.com/read/29790063/in-vitro-and-in-vivo-evaluation-of-antitumor-activity-of-ligustrum-robustum-a-chinese-herbal-tea
#14
Hao-Jiang Zuo, Shan Liu, Chun Yan, Li-Man Li, Xiao-Fang Pei
OBJECTIVE: To examine the effect of the aqueous extract of Ligustrum robustum on tumor growth in vitro and in vivo and explore the possible molecular mechanisms. METHODS: In in vitro study, cell viabilities of human cervical carcinoma cells (HeLa), human breast cancer cells (MCF-7), human prostate cancer cells (PC-3), human hepatoma cells (7721) and human colon carcinoma cells (SW480) were evaluated with cell counting kit-8. For L. robustum-treated Hela cells, early or late apoptosis were evaluated by annexin V/PI staining...
May 22, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29790056/a-10-year-trend-in-statin-use-among-older-adults-in-australia-an-analysis-using-national-pharmacy-claims-data
#15
Richard Ofori-Asenso, Jenni Ilomäki, Ella Zomer, Andrea J Curtis, Sophia Zoungas, Danny Liew
BACKGROUND: Statins have become standard of care in the prevention and treatment of atherosclerotic cardiovascular disease. The objective of this study was to examine the trends in statin use among Australians aged ≥ 65 years for the period 2007-2016. METHODS: Data from the Pharmaceutical Benefits Scheme covering a 10% random sample of the Australian population were analysed. The 1-year prevalence and incidence of statin use were determined for each year, as were the percentage of statin dispensations according to statin type or intensity and the percentage of new users prescribed each statin type or intensity...
May 23, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29789992/precise-and-economic-fib-sem-for-clem-with-2-nm-voxels-through-mitosis
#16
Manja Luckner, Gerhard Wanner
A portfolio is presented documenting economic, high-resolution correlative focused ion beam scanning electron microscopy (FIB/SEM) in routine, comprising: (i) the use of custom-labeled slides and coverslips, (ii) embedding of cells in thin, or ultra-thin resin layers for correlative light and electron microscopy (CLEM) and (iii) the claim to reach the highest resolution possible with FIB/SEM in xyz. Regions of interest (ROIs) defined in light microscope (LM), can be relocated quickly and precisely in SEM. As proof of principle, HeLa cells were investigated in 3D context at all stages of the cell cycle, documenting ultrastructural changes during mitosis: nuclear envelope breakdown and reassembly, Golgi degradation and reconstitution and the formation of the midzone and midbody...
May 23, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29789472/the-impact-of-nutrition-and-health-claims-on-consumer-perceptions-and-portion-size-selection-results-from-a-nationally-representative-survey
#17
Tony Benson, Fiona Lavelle, Tamara Bucher, Amanda McCloat, Elaine Mooney, Bernadette Egan, Clare E Collins, Moira Dean
Nutrition and health claims on foods can help consumers make healthier food choices. However, claims may have a 'halo' effect, influencing consumer perceptions of foods and increasing consumption. Evidence for these effects are typically demonstrated in experiments with small samples, limiting generalisability. The current study aimed to overcome this limitation through the use of a nationally representative survey. In a cross-sectional survey of 1039 adults across the island of Ireland, respondents were presented with three different claims (nutrition claim = "Low in fat"; health claim = "With plant sterols...
May 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29789354/uk-patients-lose-legal-claim-that-depuy-metal-on-metal-hip-implant-was-defective
#18
Clare Dyer
No abstract text is available yet for this article.
May 22, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29789234/exploring-positive-surgical-margins-after-minimally-invasive-radical-prostatectomy-does-body-habitus-really-make-a-difference
#19
S Albisinni, J Grosman, F Aoun, T Quackels, A Peltier, R Van Velthoven, T Roumeguère
BACKGROUND: Positive surgical margins (PSMs) at radical prostatectomy (RP) are generally recognized as a surrogate of poor or difficult dissection of the prostatic gland. In open RP cohorts, obesity seems to be associated to an increased risk of PSMs, probably due to the technical challenge that obese men pose to surgical access. Minimally invasive RP has been claimed to possibly reduce PSM rate. Aim of the study was to explore the impact of obesity and body habitus on PSM risk and their localisation during laparoscopic and robotic-assisted RP...
May 19, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29789186/a-population-based-assessment-of-depression-and-anxiety-in-patients-with-brachial-plexus-injuries
#20
Sarah M Yannascoli, Dustin Stwalley, Mohammed J Saeed, Margaret A Olsen, Christopher J Dy
PURPOSE: Reactive depression and anxiety are common after major life changes such as brachial plexus injuries (BPI). The purpose of this study was to evaluate the incidence and risk factors for coded depression and coded anxiety among patients with BPI using a national database of commercial insurance claims. METHODS: We used the Truven MarketScan database from 2007 to 2013 to identify commercially insured patients aged 18 to 64 years who underwent BPI surgery. For comparison, a control group without BPI was frequency-matched 10:1 by age group, sex, number of provider visits, and length of insurance enrollment...
May 19, 2018: Journal of Hand Surgery
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