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Cervical dysplasia

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https://www.readbyqxmd.com/read/29043712/uterus-dysplasia-associated-with-cervico-vaginal-agenesis
#1
Ali Mahdavi, Hadi Mirfazaelian, Ladan Younesi Asl, Zeynab Hasani, Maryam Bahreini
Müllerian ducts can form upper parts of normal female reproductive system and any failure in ductal fusion may result in to müllerian duct anomalies (MDA). We present a case of MDA and a uterus dysplasia with no evidence of cervical or upper vaginal tissue. This case showes the role of magnetic resonace imaging (MRI) on MDA diagnosis and urges the need for a unified reliable and practical classification more compatible with clinical practice.
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29036235/-medicaments-and-oral-healthcare-5-adverse-effects-of-medications-and-over-the-counter-drugs-on-teeth
#2
C de Baat, P G M A Zweers, C van Loveren, A Vissink
Intrinsic tooth discoloration may occur as an adverse effect of fluoride and tetracyclines. Extrinsic tooth discoloration may occur as superficial staining or as discoloration of the superficial pellicle and/or biofilm due to chlorhexidine, liquid iron salts, essential oils, some antibiotics and stannous fluoride. Inhibition of orthodontic tooth movement has been reported due to the use of prostaglandin synthetase inhibitors. If medications or over-the-counter drugs induce hyposalivation or contain much sucrose, caries may develop...
October 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29025633/association-between-male-circumcision-and-women-s-biomedical-health-outcomes-a-systematic-review
#3
Jonathan M Grund, Tyler S Bryant, Inimfon Jackson, Kelly Curran, Naomi Bock, Carlos Toledo, Joanna Taliano, Sheng Zhou, Jorge Martin Del Campo, Ling Yang, Apollo Kivumbi, Peizi Li, Sherri Pals, Stephanie M Davis
BACKGROUND: Male circumcision reduces men's risk of acquiring HIV and some sexually transmitted infections from heterosexual exposure, and is essential for HIV prevention in sub-Saharan Africa. Studies have also investigated associations between male circumcision and risk of acquisition of HIV and sexually transmitted infections in women. We aimed to review all evidence on associations between male circumcision and women's health outcomes to benefit women's health programmes. METHODS: In this systematic review we searched for peer-reviewed and grey literature publications reporting associations between male circumcision and women's health outcomes up to April 11, 2016...
November 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29021820/introduction-of-p16-ink4a-as-a-surrogate-biomarker-for-hpv-in-women-with-invasive-cervical-cancer-in-sudan
#4
Hina Sarwath, Devendra Bansal, Nazik Elmalaika Husain, Mahmoud Mohamed, Ali A Sultan, Shahinaz Bedri
BACKGROUND: Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16(INK4a) in squamous cell carcinoma (SCC) of the cervix by immunohistochemistry (IHC) and determine relation with clinico-pathological parameters. This study further explored the correlation of p16(INK4a) immunostaining with another proliferation marker, Ki-67 and to study if human papillomavirus (HPV) IHC can be used as a marker for detection of virus in high-grade dysplasia...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28990901/corrigendum-association-of-codon-72-polymorphism-of-p53-with-the-severity-of-cervical-dysplasia-e6-t350g-and-hpv16-variant-lineages-in-hpv16-infected-women
#5
George D Moschonas, Dimitris Tsakogiannis, Konstantinos A Lamprou, Eirini Mastora, Tilemachos G Dimitriou, Zaharoula Kyriakopoulou, Christine Kottaridi, Petros Karakitsos, Panayotis Markoulatos
No abstract text is available yet for this article.
October 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28989018/optimization-of-a-vaginal-suppository-formulation-to-deliver-sheta2-as-a-novel-treatment-for-cervical-dysplasia
#6
Sanjida Mahjabeen, Manolya K Hatipoglu, Vishal Chandra, Doris M Benbrook, Lucila Garcia-Contreras
Cervical dysplasia induced by the human papilloma virus (HPV) unpredictably progresses to cervical cancer. Therapeutic options are invasive and affect the patient's quality of life. SHetA2 has demonstrated therapeutic efficacy against human and murine HPV- induced tumors, but its oral bioavailability is <1%. An optimized vaginal suppository formulation can deliver SHetA2 in sufficient doses to prevent cervical dysplasia. The quality by design (QbD) approach was employed to optimize the suppository formulation consisting of cocoa butter as base with 5% Kolliphor and 40% SHetA2...
October 5, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28956458/9-valent-human-papillomavirus-vaccine-a-review-of-the-clinical-development-program
#7
Alain Luxembourg, Erin Moeller
The 9-valent human papillomavirus (9vHPV) vaccine covers the same HPV types (6/11/16/18) as the quadrivalent HPV (qHPV) vaccine and 5 additional cancer-causing types (31/33/45/52/58). Epidemiological studies indicate that the 9vHPV vaccine could prevent approximately 90% of cervical cancers, 70-85% of high-grade cervical dysplasia (precancers), 85-95% of HPV-related vulvar, vaginal, and anal cancers, and 90% of genital warts. Areas covered: Study design features and key findings from the 9vHPV vaccine clinical development program are reviewed...
October 9, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28953128/incidence-of-anal-dysplasia-in-a-population-of-high-risk-women-observations-at-a-cervical-pathology-unit
#8
María de Los Reyes Oliver-Pérez, Victoria Bravo Violeta, Beatriz Legorburu Alonso, Diana Betancor Pérez, Vicente Bebia Conesa, Jesús S Jiménez López
OBJECTIVES: This study aimed to evaluate the incidence of anal dysplasia in women at high risk of developing those lesions and to assess the relationships between positive anal cytology and different risk factors. MATERIALS AND METHODS: We performed an observational cross-sectional study involving a patient survey and chart review. The study was conducted at the cervical pathology unit at the Hospital Universitario 12 de Octubre, Madrid, Spain, from 2011 to 2015...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28953118/large-loop-excision-of-the-transformation-zone-versus-true-cone-biopsy-electrode-excision-a-randomized-trial
#9
Ziad Hilal, Günther A Rezniczek, Nariman El-Fizazi, Clemens B Tempfer
OBJECTIVES: The aim of the study was to compare two conization techniques, large loop excision of the transformation zone (LLETZ), and true cone biopsy electrode excision (TCBEE) in women with cervical dysplasia. MATERIALS AND METHODS: In a randomized clinical trial, we compared LLETZ and TCBEE in women undergoing surgical treatment of cervical dysplasia in a 1:1 ratio. The primary endpoint was resection margin status (RMS), secondary endpoints were fragmentation of the surgical specimen, resection volume, operation time, time to complete hemostasis, blood loss, intraoperative and postoperative complications, surgeon's preference, and patient's postoperative pain, estimated by an 11-level visual analog scale (nVAS11), and a 5-level pictogram...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28940341/the-case-for-resource-sensitivity-why-it-is-ethical-to-provide-cheaper-less-effective-treatments-in-global-health
#10
Govind C Persad, Ezekiel J Emanuel
When Dr. Hortense screens her patients in Chicago for cervical dysplasia and cancer, she conducts a pelvic exam, takes a sample of cervical cells, and sends them for Pap cytology and human papilloma virus DNA co-testing. But when she conducts cervical cancer screening in Botswana, she employs a much simpler diagnostic strategy. She applies acetic acid to highlight precancerous lesions and visually inspects the cervix-a technique known as the VIA (visual inspection with acetic acid) method. She treats suspicious lesions with cryotherapy...
September 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28929367/lacking-a-primary-care-physician-is-associated-with-increased-suffering-in-patients-with-severe-mental-illness
#11
Cynthia G Olsen, John M Boltri, Jenna Amerine, Mark E Clasen
We evaluated the relationship between lack of a primary care physician (PCP) and patients with severe mental illness (SMI), who have poorer health and experience more suffering. Using a blinded retrospective record review of 137 patients with SMI, divided between inpatients (n = 70) and outpatients (n = 67), we compared the two groups to determine if lack of a PCP is associated with increased suffering and worse overall health. We included history of preventive services, having a PCP, and comorbid conditions...
September 19, 2017: Journal of Primary Prevention
https://www.readbyqxmd.com/read/28919616/detection-of-human-papilloma-virus-by-molecular-method-from-patients-attending-at-colposcopy-clinic-of-mymensingh-medical-college-hospital-mymensingh
#12
H Begum, M A Hossain, S K Paul, S A Nasreen, S Ahmed, S Nahar, S Monwar, F Nahar, S Roy, S A Abdullah, S Abedin, M U Ahmed, T K Barman
Cervical cancer is the second most common cancer in women worldwide. Human papillomavirus (HPV) is considered as the main cause of invasive cervical cancer and cervical intra-epithelial neoplasia. High risk HPV DNA has been shown to be present in 99.7% of cervical cancers. So HPV DNA testing for screening of cervical cancers may play a potential role in early detection and management of cervical cancer. With above background a cross sectional study was undertaken to estimate the prevalence and to identify the associated risk factors of human Papillomavirus infection among Visual Inspection with Acetic acid (VIA) positive women attending at colposcopy clinic of Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from July 2013 to December 2014...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28912198/frequency-of-low-value-care-in-alberta-canada-a-retrospective-cohort-study
#13
Finlay A McAlister, Meng Lin, Jeff Bakal, Stafford Dean
OBJECTIVE: To determine how frequently 10 low-value services highlighted by Choosing Wisely are done and what factors influence their provision. METHODS: This is a retrospective cohort study using routinely collected health data from five linked data sets from 2012 to 2015 in the Canadian province of Alberta to determine the frequency with which 10 low-value services were provided. RESULTS: Between 2012 and 2015, 162 143 people (4% of all 3 814 536 adult Albertans and 5% of the 3 423 135 who saw a physician at least once in that time frame) received at least one of the 10 low-value services, including 29...
September 14, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28891195/prevalence-of-synchronous-bilateral-tonsil-squamous-cell-carcinoma-a-retrospective-study
#14
M S Rokkjaer, T E Klug
OBJECTIVES: The prevalence of synchronous bilateral tonsil cancer remains unexplored. To date, only 38 cases have been described in the literature. With an aim to substantiate the Danish recommendation of performing bilateral tonsillectomy in patients with suspected or proven tonsil cancer and in patients with cervical carcinoma metastasis from an unknown primary tumour, this study was undertaken to determine the prevalence of synchronous bilateral tonsil cancer. DESIGN: A retrospective review of all patients diagnosed with tonsil cancer in the period 2000-2015, Aarhus University Hospital, Denmark, was performed...
September 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28883273/regression-of-uterine-cervical-diffuse-large-b-cell-lymphoma-transformed-from-mucosa-associated-lymphoid-tissue-lymphoma-subsequent-to-chlamydia-trachomatis-eradication
#15
Toshitaka Mutoh, Hiroshi Takatsuki, Kiyohito Mannoji, Kyoko Kawamura, Naofumi Okura, Koichi Ohshima
A 37-year-old-woman was referred to our center after her uterine cervix health screening presented abnormal findings. We performed a biopsy of the uterine cervix to examine for cervical dysplasia, and diagnosed a diffuse large B-cell lymphoma transformed from mucosa-associated lymphoid tissue (MALT) lymphoma of the cervix. The patient presented with concurrent chlamydial cervicitis and received eradication therapy for Chlamydia trachomatis. Four months later, the CD20 positive abnormal lymphocyte disappeared and complete remission was achieved...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28878914/a-novel-keratin-13-variant-in-a-four-generation-family-with-white-sponge-nevus
#16
Stephanie B de Haseth, Egbert Bakker, Maarten H Vermeer, Hakima El Idrissi, Tjalling Bosse, Vincent T H B M Smit, Anna Terron-Kwiatkowski, W H Irwin McLean, Alexander A W Peters, Frederik J Hes
We report a novel KRT13 germ line variant that causes white sponge nevus (WSN) with mucosal dysplasia. Genital, vaginal, and cervical WSN were observed in four female patients, of whom two had premalignant cervical lesions at young age. Two of the 12 patients with oral WSN developed oral squamous cell carcinoma.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28870901/nicotinamide-phosphoribosyl-transferase-a-reliable-marker-of-progression-in-cervical-dysplasia
#17
Moiz Vora, Lubna A Alattia, Junaid Ansari, Menchu Ong, James Cotelingam, Domenico Coppola, Rodney Shackelford
BACKGROUND/AIM: Nicotinamide phosphoribosyl transferase (Nampt) catalyses the rate-limiting step of the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway. Nampt is highly expressed in several epithelial and mesenchymal neoplasms, where is promotes cell-cycle progression ans chemotherapy resistance. To our knowledge, alterations in Nampt expression have not been examined in cervical intraepithelial neoplasia (CIN) or squamous cell carcinoma (SCC). MATERIALS AND METHODS: We performed immunohistochemical analysis for Nampt using tissue microarrays on 14 samples of benign cervical squamous epithelium and 15 CIN I, 15 CIN II, and 13 samples of CIN III...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870155/pessary-or-progesterone-to-prevent-preterm-delivery-in-women-with-short-cervical-length-the-quadruple-p-randomised-controlled-trial
#18
Maud D van Zijl, Bouchra Koullali, Christiana A Naaktgeboren, Ewoud Schuit, Dick J Bekedam, Etelka Moll, Martijn A Oudijk, Wilhelmina M van Baal, Marjon A de Boer, Henricus Visser, Joris van Drongelen, Flip W van de Made, Karlijn C Vollebregt, Moira A Muller, Mireille N Bekker, Jozien T J Brons, Marieke Sueters, Josje Langenveld, Maureen T Franssen, Nico W Schuitemaker, Erik van Beek, Hubertina C J Scheepers, Karin de Boer, Eveline M Tepe, Anjoke J M Huisjes, Angelo B Hooker, Evelyn C J Verheijen, Dimitri N Papatsonis, Ben Willem J Mol, Brenda M Kazemier, Eva Pajkrt
BACKGROUND: Preterm birth is in quantity and in severity the most important topic in obstetric care in the developed world. Progestogens and cervical pessaries have been studied as potential preventive treatments with conflicting results. So far, no study has compared both treatments. METHODS/DESIGN: The Quadruple P study aims to compare the efficacy of vaginal progesterone and cervical pessary in the prevention of adverse perinatal outcome associated with preterm birth in asymptomatic women with a short cervix, in singleton and multiple pregnancies separately...
September 4, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28865151/immune-evasion-mechanisms-of-human-papillomavirus-an-update
#19
REVIEW
Alina Steinbach, Angelika B Riemer
Human papillomavirus (HPV) is the most frequently sexually transmitted agent in the world. It can cause cervical and other ano-genital malignancies, as well as oropharyngeal cancer. HPV has the unique ability to persist in the host's epithelium for a long time - longer than most viruses do - which is necessary to complete its replication cycle. To this end, HPV has developed a variety of immune evasion mechanisms, which unfortunately also favor the progression of the disease from infection to chronic dysplasia and eventually to cancer...
September 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28860942/accuracy-of-cervical-cytology-comparison-of-diagnoses-of-100-pap-smears-read-by-four-pathologists-at-three-hospitals-in-norway
#20
Sveinung Wergeland Sørbye, Pål Suhrke, Berit Wallem Revå, Jannicke Berland, Ramona Johansen Maurseth, Khalid Al-Shibli
BACKGROUND: Cervical cancer can be prevented by early detection and treatment for precancerous lesions. Since 1995, there has been a national cervical cancer screening program in Norway, where women aged 25-69 years are recommended to take Pap smears every three years. There are 17 cytology laboratories covering a population of 5 million people. The detection rate of cervical abnormalities varies from laboratory to laboratory. We wanted to investigate the accuracy of cytology diagnoses by four different pathologists at three different hospitals in Norway...
2017: BMC Clinical Pathology
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