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Cervical dysplasia

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https://www.readbyqxmd.com/read/28333902/proteflazid%C3%A2-and-local-immunity-in-diseases-caused-by-human-papillomavirus-herpesvirus-and-mixed-urogenital-infections
#1
Vjacheslav Kaminsky, Viktor Chernyshov, Oleksandr Grynevych, Vasil Benyuk, Alla Kornatskaya, Miroslava Shalko, Igor Usevich, Oleg Revenko, Maxim Shepetko, Ludmila Solomakha
Reporting of clinical trials results for Proteflazid® in the drug formulation suppositories and vaginal swabs soaked in the solution of the drug to the local immunity of the female reproductive tract. AIM: The aim of study was to examine the state of local immunity in the reproductive tract of women with sexually transmitted diseases caused by human papillomavirus, herpes viruses (Type 1, 2) and mixed infection (herpes viruses + chlamydia). MATERIALS AND METHODS: The trials involved 216 women with viral sexually transmitted diseases: Cervical Dysplasia associated with papillomavirus infection (HPV) (Group 1); Herpes genitalis type 1 (HSV- 1) and type 2 (HSV-1) (Group 2); mixed infection - HSV-1, HSV-2 and chlamydia (Group 3)...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28321993/metatropic-dysplasia-a-skeletal-dysplasia-with-challenging-airway-and-other-anesthetic-concerns
#2
Mary C Theroux, Martha Lopez, Patricia J Olszewsky, Sabina DiCindio, Lynda Arai, Colleen Ditro, Michael B Bober, Olubukola Opeyemi Olla, Tetsu Uejima, David W West, William G Mackenzie
BACKGROUND: Metatropic dysplasia is a rare form of skeletal dysplasia requiring multiple anesthetics for surgical and imaging procedures, most of which are orthopedic procedures. We provide centralized care to patients with skeletal dysplasia at our tertiary care pediatric hospital, and we were able to collect the largest number of metatropic dysplasia patients reported to date. AIM: The aim of this retrospective study was to describe and characterize the anesthetic difficulties in this high-risk population...
March 21, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28270859/genetic-variability-in-e6-e7-and-l1-genes-of-human-papillomavirus-62-and-its-prevalence-in-mexico
#3
Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy
BACKGROUND: Human papillomavirus (HPV) is the main etiological agent of cervical cancer, the third most common cancer among women globally and the second most frequent in Mexico. Persistent infection with high-risk HPV genotypes is associated with premalignant lesions and cervical cancer development. HPVs considered as low risk or not yet classified, are often found in coinfection with different HPV genotypes. Indeed, HPV62 is one of the most prevalent HPV detected in some countries, but there is limited information about its prevalence in other regions and there are no HPV62 variants currently described...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28249711/comparison-of-ffpe-histological-versus-lbp-cytological-samples-for-hpv-detection-and-typing-in-cervical-cancer
#4
Geehyuk Kim, Hyemi Cho, Dongsup Lee, Sunyoung Park, Jiyoung Lee, Hye-Young Wang, Sunghyun Kim, Kwang Hwa Park, Hyeyoung Lee
Human papillomavirus (HPV) infection is closely associated with cervical cancer. This study analyzed HPV genotype prevalence in 75 cases of formalin-fixed paraffin embedded (FFPE) tissue samples from patients diagnosed with cervical cancer. Genotype prevalence was assessed using Reverse Blot Assay (REBA) and quantitative polymerase chain reaction (qPCR), which target the HPV L1 and HPV E6/E7 genes, respectively. HPV DNA chip tests were also performed using liquid based preparation (LBP) cytological samples from the same patients who provided the FFPE histological samples...
February 27, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28247078/congenital-double-level-cervical-spondylolysis-a-case-report-and-review-of-the-literature
#5
Norio Yamamoto, Takaaki Miki, Yoshihisa Nasu, Akihiro Nishiyama, Tomoyuki Dan'ura, Yuzuru Matsui, Toshifumi Ozaki
PURPOSE: We report a rare Japanese female who was affected with three genetic-linked diseases: double-level cervical bilateral spondylolysis in association with spina bifida occulta, cleft lip and monostotic fibrous dysplasia of the right proximal femur. The case was considered to be congenital in origin. We also review the pertinent literature of cervical spondylolysis, with a focus on the pathogenesis of multiple-level cervical spondylolysis. METHODS: A 40-year-old female presented with progressive clumsiness and numbness of the hands...
February 28, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28246983/comorbidity-profiles-among-women-with-postcoital-bleeding-a-nationwide-health-insurance-database
#6
Hsin-Li Liu, Chuan-Mei Chen, Lee-Wen Pai, Yueh-Juen Hwu, Horng-Mo Lee, Yueh-Chin Chung
PURPOSE: Most of the existing studies on postcoital bleeding (PCB) in Western countries. To date, no study has focused on the various PCB-related comorbidities in Taiwan women. This work aims to analyze and compare the presence or absence of PCB among Taiwanese women with gynecological comorbidity. METHODS: This study is a population-based retrospective cohort investigation. Outpatients with PCB after the index date were considered. A total of 2377 female patients with PCB (ICD-9 626...
February 28, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28214204/detection-of-occult-endocervical-glandular-dysplasia-in-cervical-conization-specimens-for-squamous-lesions
#7
F Sopracordevole, N Clemente, L Alessandrini, J Di Giuseppe, F Cigolot, M Buttignol, A Ciavattini, V Canzonieri
The aim of this work was to evaluate the incidence of occult cervical glandular intraepithelial neoplasia (CGIN) and adenocarcinoma of the cervix (AC) in women treated with CO2-laser conization for cervical intraepithelial neoplasia (CIN) or squamocellular cervical cancer (SCC). The medical records of all women with a histological diagnosis of squamous lesions of the uterine cervix (persistent CIN1, CIN2, CIN3 and SCC) who were subsequently treated with CO2-laser conization at our institution, during the period from January 1991 to December 2014, were analyzed in a retrospective case series...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28209524/foxa1-in-hpv-associated-carcinomas-its-expression-in-carcinomas-of-the-head-and-neck-and-of-the-uterine-cervix
#8
Georgia Karpathiou, Vanessa Da Cruz, Francois Casteillo, Mousa Mobarki, Jean Marc Dumollard, Celine Chauleur, Fabien Forest, Jean Michel Prades, Michel Peoc'h
BACKGROUND: FOXA1 is a major transcription factor involved in the action of human papilloma virus (HPV). However, it has been never studied in HPV-associated tumors. AIM OF THE STUDY: To investigate its expression in cervical and head and neck tumors. MATERIAL AND METHODS: 63 cervical carcinomas/dysplasias and 152 head and neck squamous cell carcinomas (HNSCC) were immunohistochemically studied for the expression of FOXA1. RESULTS: 63...
February 14, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28184171/implementing-visual-cervical-cancer-screening-in-senegal-a-cross-sectional-study-of-risk-factors-and-prevalence-highlighting-service-utilization-barriers
#9
J Andrew Dykens, Annē M Linn, Tracy Irwin, Karen E Peters, Maria Pyra, Fatoumata Traoré, Mariama Touré Diarra, Memoona Hasnain, Katie Wallner, Patrick Linn, Youssoupha Ndiaye
BACKGROUND: Senegal ranks 15th in the world in incidence of cervical cancer, the number one cause of cancer mortality among women in this country. The estimated participation rate for cervical cancer screening throughout Senegal is very low (6.9% of women 18-69 years old), especially in rural areas and among older age groups (only 1.9% of women above the age of 40 years). There are no reliable estimates of the prevalence of cervical dysplasia or risk factors for cervical dysplasia specific to rural Senegal...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28161543/anal-study-in-immunocompetent-women-with-human-papillomavirus-related-lower-genital-tract-pathology
#10
Concepción Donaire, Marcos Reillo, Juan C Martínez-Escoriza, José A López-Fernández
OBJETIVE: To estimate the prevalence of anal dysplasia in immunocompetent women with cervical intraepithelial dysplasia. STUDY DESIGN: We did a prospective cohort study, in which we enrolled 166 women with gynecological pathology related to human papilloma virus (HPV) infection. All patients underwent an anal cytology and HPV detection. Statistical analysis with a 95% confidence interval was used for prevalence calculations. A Χ2 test and Fisher's exact one were used to determine differences between groups of qualitative variables...
January 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28158224/development-of-a-simple-and-quick-immunochromatography-method-for-detection-of-anti-hpv-16-18-antibodies
#11
Fumiko Endo, Tsutomu Tabata, Daichi Sadato, Machiko Kawamura, Noriyuki Ando, Keisuke Oboki, Masako Ukaji, Kaoru Kobayashi, Yukuharu Kobayashi, Tomoaki Ikeda, Futoshi Shibasaki
Immunochromatography (IC) is widely used to detect target molecules in biological fluids. Since this method can be performed without a special technique or device, IC is a convenient way to assess the existence of antibodies or pathogens such as viruses and bacteria, simply and quickly. In this study, we established an IC method to detect serum antibodies against oncogenic human papillomavirus (HPV)-16 and HPV-18 L1 proteins using recombinant L1 proteins produced by silkworms as antigens. Infection of oncogenic HPVs is a major risk factor of cervical cancer, which is one of the most common cancers in women worldwide...
2017: PloS One
https://www.readbyqxmd.com/read/28150409/bizarre-cell-dysplasia-of-the-cervix
#12
Ondrej Ondič, Radoslav Ferko, Jana Kašpírková, Marián Švajdler, Boris Rýchly, Peter Talarčík, Jiří Bouda, Michal Michal
AIM: The aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (HSIL) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (BCD). METHODS: A total of 29 cervical cone biopsy samples of this type of dysplasia were studied. Multi-target polymerase chain reaction and in situ hybridization human papillomavirus (HPV) detection was performed in all cases. BCD was defined as a subtype of HSIL characterized by the presence of large dysplastic cells with abnormal, large pleomorphic nuclei or multinucleation causing nucleomegaly...
February 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28141783/prevalence-of-anal-hpv-and-anal-dysplasia-in-hiv-infected-women-from-johannesburg-south-africa
#13
Bridgette J Goeieman, Cynthia S Firnhaber, Eefje Jong, Pam Michelow, Avril Swarts, Anna-Lise Williamson, Bruce Allan, Jennifer S Smith, Patricia Kegorilwe, Timothy J Wilkin
BACKGROUND: Anal cancer is a relatively common cancer among HIV-infected populations. There are limited data on the prevalence of anal high-risk human papillomavirus (HR-HPV) infection and anal dysplasia in HIV-infected women from resource-constrained settings. METHODS: A cross-sectional study of HIV-infected women age 25-65 recruited from an HIV clinic in Johannesburg, South Africa. Cervical and anal swabs were taken for conventional cytology and HR-HPV testing...
January 30, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28123559/cervical-intraepithelial-neoplasia-in-pregnancy-interference-of-pregnancy-status-with-p16-and-ki-67-protein-expression
#14
Andrea Ciavattini, Francesco Sopracordevole, Jacopo Di Giuseppe, Lorenzo Moriconi, Guendalina Lucarini, Francesca Mancioli, Antonio Zizzi, Gaia Goteri
To date, there are evidence-based guidelines available for cervical dysplasia diagnosed in pregnancy. Certain functional biomarkers have proven useful in the prediction of regressing and non-regressing cervical intraepithelial neoplasia (CIN) lesions in non-pregnant women. In the present study, Ki-67 and p16 immunostaining were evaluated in different grades of CIN lesions diagnosed in pregnant or non-pregnant women with the aim to identify any differences in order to better understand the behavior of CIN in pregnancy...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28120818/pregnancy-and-menopause-in-patients-with-systemic-lupus-erythematosus-and-or-antiphospholipid-syndrome-practical-guide-from-eular
#15
Roberta Vagelli, Chiara Tani, Marta Mosca
Over the last few decades, in reproductive medicine have allowed an improvement in the management and outcome of pregnancy in connective tissue diseases (CTD), such as Systemic progress Lupus Erythematosus and Antiphospholipid Syndrome; however, pregnancy and other related issues represent a crucial moment for patients and their family and some unmet needs are still present. In routine clinical practise, health professionals involved in the care of SLE and/or APS patients need to consider many aspects of the reproductive life of patients, involving not only pregnancy and family planning but also fertility, contraception, cancer surveillance and menopause...
January 25, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28116194/endocervical-carcinogenesis-and-hpv-vaccination-an-occasional-circumstance-or-a-gap-in-the-chain
#16
Georgios-Marios Makris, Petros Karakitsos, Eugenia Kotsifa, Niki Margari, Nikiforita Poulakaki, Theodoros N Sergentanis, Marco-Johannes Battista, Charalampos Chrelias, Nicolaos Papantoniou
As a result of the Human Papillomavirus (HPV) vaccination program, the prevalence of precancerous dysplasia and invasive cervical cancer has substantially decreased. In this brief report, we present a case of a young patient who was diagnosed with in situ adenocarcinoma of the cervix. This 30-year-old female had completed the HPV vaccination after she became sexually active and has been undergoing annual gynecological assessments, including clinical examination and Pap test, all of which had been negative. This year, her Pap test revealed a low grade squamous intraepithelial lesion (LGSIL) and additionally a colposcopy was performed...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28093271/characterization-and-clinical-validation-of-mcm2-and-top2a-monoclonal-antibodies-in-the-bd-proex%C3%A2-c-assay-an-immunoassay-which-detects-aberrant-s-phase-induction-in-cervical-tissue
#17
Eric P Dixon, Lorraine M King, Ramona Nelson, Stephen G Simkins, Steven L Knapp, George H Brough, Karen L Lenz, Dorian T Henderson, Clark M Whitehead, Janice Hessling, Charlotte A Brown, Douglas P Malinowski
BACKGROUND: The Papanicolaou (Pap) screen has been successful in reducing cervical cancer; but exhibits low sensitivity when detecting cervical dysplasia. Use of molecular biomarkers in Pap tests may improve diagnostic accuracy. DESIGN: Monoclonal antibodies to Minichromosome Maintenance Protein 2 (MCM2) and DNA Topoisomerase II α (TOP2A) were selected for use in IHC based on their ability to differentiate normal from diseased cervical tissues in tissue microarrays...
January 16, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28086933/self-collection-based-hpv-testing-for-cervical-cancer-screening-among-women-living-with-hiv-in-uganda-a-descriptive-analysis-of-knowledge-intentions-to-screen-and-factors-associated-with-hpv-positivity
#18
Sheona M Mitchell, Heather N Pedersen, Evelyn Eng Stime, Musa Sekikubo, Erin Moses, David Mwesigwa, Christine Biryabarema, Jan Christilaw, Josaphat K Byamugisha, Deborah M Money, Gina S Ogilvie
BACKGROUND: Women living with HIV (WHIV) are disproportionately impacted by cervical dysplasia and cancer. The burden is greatest in low-income countries where limited or no access to screening exists. The goal of this study was to describe knowledge and intentions of WHIV towards HPV self-collection for cervical cancer screening, and to report on factors related to HPV positivity among women who participated in testing. METHODS: A validated survey was administered to 87 HIV positive women attending the Kisenyi Health Unit aged 30-69 years old, and data was abstracted from chart review...
January 13, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28070215/multiple-hpv-infections-in-female-sex-workers-in-western-kenya-implications-for-prophylactic-vaccines-within-this-sub-population
#19
Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe, Hillary Mabeya
BACKGROUND: Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants that the synergistic effects of potential HR (pHR) and HR HPV genotypes be elucidated to assess the potential impact of prophylactic vaccines. This population in Kenya also harbours a number of other vaginal infections and STIs, including bacterial vaginosis (BV), trichomonas vaginalis (TV) and candida spp...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28056533/hemicrania-continua-in-carotid-artery-dissection-symptomatic-cases-or-linked-pathophysiology
#20
Roland Brilla, Matthias Pawlowski, Stefan Evers
Background Hemicrania continua (HC) -like headaches have been rarely reported as symptomatic headaches, including cases secondary to cervical artery dissection. Case series We present five cases of HC-like headaches following cervical artery dissection, in three cases with specific indomethacin response. In two cases, comorbidity of fibromuscular dysplasia (FMD) was noted. Conclusion Carotid artery dissection may result in an HC-like headache syndrome. A specific response to indomethacin does not rule out dissection as underlying pathology...
January 1, 2017: Cephalalgia: An International Journal of Headache
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