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https://www.readbyqxmd.com/read/29208455/high-prevalence-and-incidence-of-hpv-related-anal-cancer-precursor-lesions-in-hiv-positive-women-in-the-late-haart-era
#1
Carmen Hidalgo-Tenorio, Samantha E de Jesus, Javier Esquivias, Juan Pasquau
INTRODUCTION: Anal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV). OBJECTIVES: To evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection...
December 2, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29207716/expression-of-p16ink4a-protein-in-cervical-intraepithelial-neoplasia-and-invasive-carcinoma-of-uterine-cervix
#2
Vatsala Kishore, Anuradha G Patil
Introduction: Cervical cancer still ranks as the most frequent cancer among women in India. Infection with Human Papilloma Virus (HPV) results in precancerous lesions and invasive cervical cancer. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to upregulation of p16INK4A, a cyclin dependent kinase inhibitor. Therefore, p16INK4A overexpression is a surrogate biomarker of HPV infection making it useful in evaluating HPV associated premalignant and malignant lesions of gynaecological tract...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204065/anal-cancer-and-anal-cancer-precursors-in-women-with-a-history-of-hpv-related-dysplasia-and-cancer
#3
Elizabeth A Stier, Elizabeth Y Chiao
The epidemiology of anal cancer in the U.S. has changed over the past 3 decades. During this period the incidence of anal cancer has increased among both men and women. Of note, women with a history of anogenital HPV infection are at higher risk than the general population for anal cancer. The increased risk ranged from increased incidence rate ratios ranging from 1.82 to 6.3 in women with a history of cervical cancer, to 4.2-16.4 in women with a history of prior cervical intraepithelial neoplasia 3 (CIN 3)...
June 2017: Seminars in Colon & Rectal Surgery
https://www.readbyqxmd.com/read/29182627/human-papillomavirus-dna-detection-in-plasma-and-cervical-samples-of-women-with-a-recent-history-of-low-grade-or-precancerous-cervical-dysplasia
#4
Clementina Elvezia Cocuzza, Marianna Martinelli, Federica Sina, Andrea Piana, Giovanni Sotgiu, Tiziana Dell'Anna, Rosario Musumeci
Circulating HPV DNA has been previously described in women with advanced stages of cervical cancer and has been suggested to be a prognostic marker of disease recurrences and metastases. Only a few studies have reported the presence of HPV DNA in bloodstream of patients with low grade or precancerous cervical lesions. This study aimed to define if HPV DNA could be detected in plasma samples of 120 women referred for a recent history of cervical dysplasia who presented with lesions ranging from High Squamous Intraepithelial Lesion (H-SIL) to regressed normal cytology...
2017: PloS One
https://www.readbyqxmd.com/read/29174874/cervical-cancer-screening-and-follow-up-procedures-in-women-age-21-years-following-new-screening-guidelines
#5
Alexandra M Foxx, Yuwei Zhu, Edward Mitchel, Sayeh Nikpay, Dineo Khabele, Marie R Griffin
PURPOSE: The 2009 American College of Obstetricians and Gynecologists guidelines recommended no cervical cancer screening before age 21 years. We examined changes in screening, diagnostic, and treatment procedures for cervical dysplasia after guideline introduction, and cost implications. METHODS: We studied Davidson County women aged 18-20 years, enrolled in Tennessee Medicaid, 2006-2014. We identified those with at least one Papanicolaou (Pap) test, human papillomavirus detection test, colposcopy, or excisional dysplasia treatment annually via Current Procedural Terminology coding...
November 22, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29172031/close-resection-margins-do-not-influence-local-recurrence-in-patients-with-oral-squamous-cell-carcinoma-a-prospective-cohort-study
#6
Panagiotis Stathopoulos, William P Smith
PURPOSE: This study investigated the clinical relevance of the distance between the resection margin and tumor cells of the primary sites for oral squamous cell carcinoma, with particular attention to local recurrence rate. PATIENTS AND METHODS: All patients diagnosed with oral squamous cell carcinoma from 1995 to 2006 and treated primarily with surgery formed the initial cohort of the study. Patient with various degrees of dysplasia in the margin, patients who received radiotherapy, and patients who died of causes other than oral cancer were excluded...
November 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29168898/association-of-p16-cdkn2a-polymorphisms-with-the-development-of-hpv16-related-precancerous-lesions-and-cervical-cancer-in-the-greek-population
#7
D Tsakogiannis, G D Moschonas, E Bella, Z Kyriakopoulou, G D Amoutzias, T G Dimitriou, C Kottaridi, P Markoulatos
The tumor suppressor protein p16 plays a fundamental role in cell cycle regulation and exerts a protective effect against tumor growth. Two different polymorphisms at positions 540 and 580 at the 3'UTR of exon 3 of p16 gene are implicated in several types of cancer, while their role in cervical cancer development remains rather vague. In the present study, we investigated for the impact of p16 genotypes/haplotypes on patients' vulnerability to cervical disease and examined whether these factors can be used as progression markers in the Greek population...
November 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29159260/public-health-approach-to-prevent-cervical-cancer-in-hiv-infected-women-in-kenya-issues-to-consider-in-the-design-of-prevention-programs
#8
REVIEW
Sonia Menon, Rodolfo Rossi, Stacy G Harmon, Hillary Mabeya, Steven Callens
Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29157955/development-of-a-goat-model-for-evaluation-of-withaferin-a-cervical-implants-for-the-treatment-of-cervical-intraepithelial-neoplasia
#9
Leslie C Sherwood, Farrukh Aqil, Manicka V Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay Srivastava, Inder P Singh, Scott Cambron, Martin O'Toole, Wendy Spencer, Lynn P Parker, Ramesh C Gupta
Cervical cancer is caused by human papillomavirus (HPV). The disease develops over many years through a series of precancerous lesions. Cervical cancer can be prevented by HPV-vaccination, screening and treatment of precancer before development of cervical cancer. The treatment of high-grade cervical dysplasia (CIN(2+)) has traditionally been by cervical conization. Surgical procedures are associated with increased risk of undesirable side effects including bleeding, infection, scarring (stenosis), infertility and complications in later pregnancies...
November 17, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29142493/cervical-arterial-fibromuscular-dysplasia-in-a-biethnic-population-a-retrospective-study-in-the-u-s-mexican-border
#10
Ihtesham A Qureshi, Gustavo J Rodriguez, Tatiana Chacon-Quesada, Gavito-Higuera Jose, Salvador Cruz-Flores, Alberto Maud
Background  There have been studies trying to characterize Fibromuscular Dysplasia (FMD); however, most of them are based in mainly non-Hispanic sample. The objective of this study is to better understand the epidemiology and clinical characteristics of craniocervical FMD in the Hispanic population. Methods  We retrospectively reviewed the cerebral angiograms performed in our center in a period of 3.5 years under any indication looking for angiographic patterns of FMD. Exclusion criteria consisted of cases in which the first angiogram was done when the patients were younger than 18 years...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29137102/lateral-medullary-infarction-with-similar-features-of-brown-sequard-syndrome-caused-by-vertebrobasilar-dysplasia-and-klippel-feil-syndrome-a-case-report
#11
Jingzhe Han, Duanhua Cao, Guomei Ma, Tingting Wang, Ye Ji, Zhilei Kang
RATIONALE: Patients with Klippel-Feil syndrome (KFS) are always anomaly associated with vertebrobasilar dysplasia. That may present commonly as infarction of brainstem, medulla, and cerebellum. In this article, we reported a rare case of lateral medullary infarction (LMI) with similar features of Brown Sequard syndrome caused by vertebrobasilar dysplasia and KFS, and the 2 rare conditions that are causally related. The case is being reported because of its unusual and rare presentation...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135982/sting-expression-and-response-to-treatment-with-sting-ligands-in-premalignant-and-malignant-disease
#12
Jason R Baird, Zipeng Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, R Bryan Bell, Kristina H Young, Marka R Crittenden, Michael J Gough
Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to investigate STING ligands as a novel treatment for papilloma. We tested therapies in a spontaneous mouse model of papilloma of the face and anogenital region that histologically resembles human HPV-associated papilloma...
2017: PloS One
https://www.readbyqxmd.com/read/29112645/topical-5-fluorouracil-for-women-with-high-grade-vaginal-intraepithelial-neoplasia
#13
Stephen Fiascone, Allison F Vitonis, Sarah Feldman
OBJECTIVE: To examine success rates of 5-fluorouracil, excision, and laser ablation as the initial and secondary management strategies for women with high-grade vaginal intraepithelial neoplasia. METHODS: We conducted a retrospective case series of women referred to a single center for management of biopsy-proven, high-grade vaginal intraepithelial neoplasia between April 1994 and May 2016. Data including demographic characteristics, human papillomavirus risk factors, antecedent Pap cytology, concurrent or prior cervical and vulvar dysplasia, and treatment outcome including follow-up Pap cytology were recorded...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29112019/utility-of-p16-immunohistochemistry-in-evaluating-negative-cervical-biopsies-following-high-risk-pap-test-results
#14
Alana F Shain, Shirley Kwok, Ann K Folkins, Christina S Kong
The Lower Anogenital Squamous Terminology (LAST) Standardization Project for human papilloma virus (HPV)-associated lesions specifically recommends the use of p16 immunohistochemistry (IHC) as an adjunct to morphologic assessment of cervical biopsies interpreted as negative or low-grade squamous intraepithelial lesion (LSIL) from patients with prior high-risk Pap test results (high-grade squamous intraepithelial lesion [HSIL], atypical squamous cells cannot exclude HSIL, atypical glandular cells [AGC], or HPV16 atypical squamous cells of undetermined significance [ASC-US])...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29108943/therapeutic-hpv-vaccines
#15
REVIEW
Gemma Hancock, Karin Hellner, Lucy Dorrell
High-risk human papillomavirus (HPV) infection is known to be a necessary factor for cervical and anogenital malignancies. Cervical cancers account for over a quarter of a million deaths annually. Despite the availability of prophylactic vaccines, HPV infections remain extremely common worldwide. Furthermore, these vaccines are ineffective at clearing pre-existing infections and associated preinvasive lesions. As cervical dysplasia can regress spontaneously, a therapeutic HPV vaccine that boosts host immunity could have a significant impact on the morbidity and mortality associated with HPV...
September 28, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29107949/user-perception-of-endocervical-sampling-a-randomized-comparison-of-endocervical-evaluation-with-the-curette-vs-cytobrush
#16
Manuela Undurraga, Rosa Catarino, Isabelle Navarria, Yasmine Ibrahim, Evelyne Puget, Isabelle Royannez Drevard, Jean-Claude Pache, Jean-Christophe Tille, Patrick Petignat
OBJECTIVES: To evaluate whether the endocervical brush (ECB) is better accepted by patients and health care providers for endocervical evaluation when compared to the endocervical curette (ECC), without a decrease in the quality of sampling. METHODS: Two hundred patients with cervical dysplasia were randomized at the colposcopy clinic of the University Hospital of Geneva into two groups according to technique. Patients and physicians' preference regarding the technique as well as the quality of samples were assessed...
2017: PloS One
https://www.readbyqxmd.com/read/29094102/project-echo-a-telementoring-program-for-cervical-cancer-prevention-and-treatment-in-low-resource-settings
#17
Melissa S Lopez, Ellen S Baker, Andrea M Milbourne, Rose M Gowen, Ana M Rodriguez, Cesaltina Lorenzoni, Catherine Mwaba, Susan Citonje Msadabwe, José Humberto Tavares, Georgia Fontes-Cintra, Gustavo Zucca-Matthes, Donato Callegaro-Filho, Danielle Ramos-Martin, Icaro Thiago de Carvalho, Robson Coelho, Renato Moretti Marques, Thiago Chulam, Mila Pontremoli-Salcedo, Fernanda Nozar, Veronica Fiol, Mauricio Maza, Sanjeev Arora, Ernest T Hawk, Kathleen M Schmeler
Cervical cancer incidence and mortality rates are significantly higher in low- and middle-income countries compared with the United States and other developed countries. This disparity is caused by decreased access to screening, often coupled with low numbers of trained providers offering cancer prevention and treatment services. However, similar disparities are also found in underserved areas of the United States, such as the Texas-Mexico border, where cervical cancer mortality rates are 30% higher than in the rest of Texas...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29091164/erratum-translation-and-cultural-adaptation-of-the-functional-assessment-of-chronic-illness-therapy-cervical-dysplasia-facit-cd-to-evaluate-quality-of-life-in-women-with-cervical-intraepithelial-neoplasia
#18
https://www.readbyqxmd.com/read/29075090/women-living-with-hiv-over-age-of-65-cervical-cancer-screening-in-a-unique-and-growing-population
#19
Alexandra Aserlind, Karla Maguire, Lunthita Duthely, Stefan Wennin, JoNell Potter
OBJECTIVE: Women living with HIV are at increased risk of human papillomavirus (HPV) infection, which can lead to cervical cancer. New guidelines recommend indefinite screening. The objective of this study is to describe cervical cancer screening practices and colposcopy results in a cohort of women living with HIV over age of 65 who were followed before the new guidelines. Comorbidities, sexually transmitted infections (STIs), and other risk factors were evaluated. METHODS: We conducted a retrospective chart review on 75 women aged 65 or older living with HIV with at least one Pap smear...
2017: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29072058/p16ink4a-expression-in-cervical-lesions-correlates-with-histologic-grading-a-tertiary-level-medical-facility-based-retrospective-study
#20
Usha Sarma, Ira Biswas, Alakananda Das, Gokul Chandra Das, Chandan Saikia, Bidula Sarma
p16INK4a is a tumor-suppressor protein and cyclin-dependent kinase (cdk) inhibitor that blocks cdk4- and cdk6-mediated pRb phosphorylation to inhibit E2F-dependent transcription and cell-cycle progression. Because the E7 protein of high-risk HPVs inactivates pRB, the resulting overexpression of p16INK4a may be a good marker for infection with high risk HPV types. Immunostaining of p16INK4a allows precise identification of even small CIN or cervical cancer lesions in biopsy sections and can help reduce inter-observer variation in the histopathological interpretation of cervical biopsy specimens...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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