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https://www.readbyqxmd.com/read/29045883/in-vitro-in-vivo-correlations-of-carbamazepine-nano-dispersions-for-application-in-formulation-development
#1
Zachary Warnken, Michael Puppolo, Justin Hughey, Iris Duarte, Susan Jansen-Varnum
During formulation development, efficiently integrating in vitro dissolution testing can significantly improve one's ability to estimate in vivo performance and aide in the selection of premier drug candidates. The concept of in vitro - in vivo relationship/correlation (IVIVR/IVIVC) has garnered significant attention from pharmaceutical scientists to predict expected bioavailability characteristics for drug substances and products. The current work illustrates a comparative evaluation of in vitro tests to access crystalline carbamazepine and various types of amorphous and crystalline dispersions of carbamazepine and Eudragit L100 produced by spray-drying, including a membrane-permeation dissolution methodology and non-sink dissolution...
October 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29045472/sulfites-inhibit-the-growth-of-four-species-of-beneficial-gut-bacteria-at-concentrations-regarded-as-safe-for-food
#2
Sally V Irwin, Peter Fisher, Emily Graham, Ashley Malek, Adriel Robidoux
Sulfites and other preservatives are considered food additives to limit bacterial contamination, and are generally regarded as safe for consumption by governmental regulatory agencies at concentrations up to 5000 parts per million (ppm). Consumption of bactericidal and bacteriostatic drugs have been shown to damage beneficial bacteria in the human gut and this damage has been associated with several diseases. In the present study, bactericidal and bacteriostatic effects of two common food preservatives, sodium bisulfite and sodium sulfite, were tested on four known beneficial bacterial species common as probiotics and members of the human gut microbiota...
2017: PloS One
https://www.readbyqxmd.com/read/29045463/submillisievert-standard-pitch-ct-pulmonary-angiography-with-ultra-low-dose-contrast-media-administration-a-comparison-to-standard-ct-imaging
#3
Saravanabavaan Suntharalingam, Christian Mikat, Elena Stenzel, Youssef Erfanian, Axel Wetter, Thomas Schlosser, Michael Forsting, Kai Nassenstein
OBJECTIVES: To evaluate the image quality and radiation dose of submillisievert standard-pitch CT pulmonary angiography (CTPA) with ultra-low dose contrast media administration in comparison to standard CTPA. MATERIALS AND METHODS: Hundred patients (56 females, 44 males, mean age 69.6±15.4 years; median BMI: 26.6, IQR: 5.9) with suspected pulmonary embolism were examined with two different protocols (n = 50 each, group A: 80 kVp, ref. mAs 115, 25 ml of contrast medium; group B: 100 kVp, ref...
2017: PloS One
https://www.readbyqxmd.com/read/29045156/probing-the-interaction-mechanism-between-air-bubbles-and-bitumen-surfaces-in-aqueous-media-using-bubble-probe-afm
#4
Lei Xie, Chen Shi, Xin Cui, Jun Huang, Jingyi Wang, Qi Liu, Hongbo Zeng
Surface interactions involving deformable air bubbles have attracted tremendous interest in a wide range of engineering applications, such as mineral flotation and bitumen extraction. In this work, for the first time, the interaction forces between air bubbles and bitumen surfaces in complex aqueous media of varying pH, salinity and salts were directly measured using a bubble probe atomic force microscope (AFM) technique. The AFM topographic imaging reveals that bitumen surface tends to be rougher and form distinct domains at high NaCl concentration or under strongly alkaline environment...
October 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29045144/destabilization-propagation-and-generation-of-surfactant-stabilized-foam-during-crude-oil-displacement-in-heterogeneous-model-porous-media
#5
Siyang Xiao, Yongchao Zeng, Eric D Vavra, Peng He, Maura C Puerto, George J Hirasaki, Sibani Lisa Biswal
Foam flooding in porous media is of increasing interest due to its numerous applications such as enhanced oil recovery, aquifer remediation, and hydraulic fracturing. However, the mechanisms of oil-foam interactions have yet to be fully understood at the pore level. Here, we present three characteristic zones identified in experiments involving the displacement of crude oil from model porous media via surfactant-stabilized foam, and we describe a series of pore-level dynamics in these zones which were not observed in experiments involving paraffin oil...
October 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29045045/mesenchymal-stromal-cell-therapy-in-bronchopulmonary-dysplasia-systematic-review-and-meta-analysis-of-preclinical-studies
#6
Sajit Augustine, Marc T Avey, Brittany Harrison, Tiffany Locke, Mona Ghannad, David Moher, Bernard Thébaud
Extreme prematurity is the leading cause of death among children under 5 years of age. Currently, there is no treatment for bronchopulmonary dysplasia (BPD), the most common complication of extreme prematurity. Experimental studies in animal models of BPD suggest that mesenchymal stromal cells (MSCs) are lung protective. To date, no systematic review and meta-analysis has evaluated the preclinical evidence of this promising therapy. Our protocol was registered with Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies prior to searching MEDLINE (1946 to June 1, 2015), Embase (1947 to 2015 Week 22), Pubmed, Web of Science, and conference proceedings (1990 to present) for controlled comparative studies of neonatal animal models that received MSCs or cell free MSC-derived conditioned media (MSC-CM)...
October 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29045012/photodynamic-therapy-inhibits-melanogenesis-through-paracrine-effects-by-keratinocytes-and-fibroblasts
#7
Sue Kyung Kim, Seung-Jae Oh, Se-Yeon Park, Woo-Jung Kim, You-Sun Kim, You Chan Kim
Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In the present study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes in vitro and in vivo. Exposure of melanocytes to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing melanocytes to conditioned media of PDT-treated keratinocytes or dermal fibroblasts...
October 17, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29045011/consumer-health-information-seeking-in-social-media-a-literature-review
#8
REVIEW
Yuehua Zhao, Jin Zhang
OBJECTIVE: The objective of this literature review was to summarise current research regarding how consumers seek health-related information from social media. Primarily, we hope to reveal characteristics of existing studies investigating the health topics that consumers have discussed in social media, ascertaining the roles social media have played in consumers' information-seeking processes and discussing the potential benefits and concerns of accessing consumer health information in social media...
October 17, 2017: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/29044975/comparative-proteomic-analysis-of-three-xanthomonas-spp-cultured-in-minimal-and-rich-media
#9
Hey-Jee Park, Nahee Bae, Hanbi Park, Dae-Wi Kim, Sang-Wook Han
Bacteria change their gene expression when exposed to different nutrient conditions. The levels of proteins do not always correlate with those of RNAs, hence proteomic analysis is required for understanding how bacteria adapt to different conditions. Herein, differentially abundant proteins from Xanthomonas oryzae pv. oryzae (Xoo), X. campestris pv. vesicatoria (Xcv), and X. axonopodis pv. glycines (Xag), which were cultured in rich media and in minimal media, were determined using label-free shotgun proteomic analysis and clusters of orthologous groups classification...
October 17, 2017: Proteomics
https://www.readbyqxmd.com/read/29044864/experimental-proof-of-the-bifunctional-mechanism-for-the-hydrogen-oxidation-in-alkaline-media
#10
Jingkun Li, Shraboni Ghoshal, Michael K Bates, Todd E Miller, Veronica Davies, Eli Stavitski, Klaus Attenkofer, Sanjeev Mukerjee, Zi-Feng Ma, Qingying Jia
Realization of the hydrogen economy relies on effective hydrogen production, storage, and utilization. The slow kinetics of hydrogen evolution and oxidation reaction (HER/HOR) in alkaline media limits many practical applications involving hydrogen generation and utilization, and how to overcome this fundamental limitation remains debatable. Here we present a kinetic study of the HOR on representative catalytic systems in alkaline media. Electrochemical measurements show that the HOR rate of Pt-Ru/C and Ru/C systems is decoupled to their hydrogen binding energy (HBE), challenging the current prevailing HBE mechanism...
October 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29044545/predicted-global-warming-scenarios-impact-on-the-mother-plant-to-alter-seed-dormancy-and-germination-behavior-in-arabidopsis
#11
Z Huang, S Footitt, A Tang, W E Finch-Savage
Seed characteristics are key components of plant fitness that are influenced by temperature in their maternal environment, and temperature will change with global warming. To study the effect of such temperature changes, Arabidopsis thaliana plants were grown to produce seeds along a uniquely designed polyethylene tunnel having a thermal gradient reflecting local global warming predictions. Plants therefore experienced the same variations in temperature and light conditions, but different mean temperatures...
October 17, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29044523/osseointegration-of-zirconia-and-titanium-implants-in-a-rabbit-tibiae-model-evaluated-by-microtomography-histomorphometry-and-fluorochrome-labeling-analyses
#12
R Martins, T M Cestari, R V N Arantes, P S Santos, R Taga, M J Carbonari, R C Oliveira
OBJECTIVES: This study compares the osseointegration of machined-zirconia implants containing yttria (M-Y-TZP) with machined (M-Ti) and resorbable blast media (RBM-Ti) titanium implants. MATERIAL AND METHODS: M-Y-TZP, M-Ti and RBM-Ti implants were randomly placed in rabbit tibiae. Fluorochrome bone labels (tetracycline, alizarin and calcein) were administered at different time periods. After 8 weeks, osseointegration was evaluated in terms of bone-to-implant contact (BIC), new bone area (nBA), remaining cortical bone area (rBA) and temporal quantification of fluorochromes, using micro-CT and histomorphometric analyses...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29044520/quercetin-protects-against-radiocontrast-medium-toxicity-in-human-renal-proximal-tubular-cells
#13
Michele Andreucci, Teresa Faga, Antonio Pisani, Raffele Serra, Domenico Russo, GIovambattista De Sarro, Ashour Michael
Radiocontrast media (RCM)-induced acute kidney injury (CI-AKI) is a major clinical problem whose, pathophysiology is not well understood. Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI. We investigated the effect of quercetin on human renal proximal tubular (HK-2) cells treated with the radiocontrast medium (RCM) sodium diatrizoate. Quercetin is the most widely studied flavonoid, and the most abundant flavonol present in foods...
October 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29044294/serum-levels-of-anti-pon1-and-anti-hdl-antibodies-as-potential-biomarkers-of-premature-atherosclerosis-in-systemic-lupus-erythematosus
#14
Patricia López, Javier Rodríguez-Carrio, Aleida Martínez-Zapico, Ángel I Pérez-Álvarez, Raquel López-Mejías, Lorena Benavente, Lourdes Mozo Mozo, Luis Caminal-Montero, Miguel A González-Gay, Ana Suárez
The present study aimed to evaluate the possible role of immunoglobulin G (IgG) antibodies against high-density lipoproteins (HDL) and paraoxonase 1 (PON1) as possible biomarkers of cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). To this end, levels of these autoantibodies, PON1 activity and total antioxidant capacity were quantified in serum samples from 198 SLE patients, 100 healthy controls (HC) and 42 non-autoimmune individuals with traditional cardiovascular risk factors. PON1 rs662 polymorphism was analysed in a subgroup of patients and controls...
October 10, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29044222/rapid-generation-and-detection-of-biomimetic-oxygen-concentration-gradients-in-vitro
#15
Daud H Khan, Steven A Roberts, John Robert Cressman, Nitin Agrawal
Hypoxic regions exist within most solid tumors and often lead to altered cellular metabolism, metastasis, and drug resistance. Reliable generation and detection of biomimetic gaseous gradients in vitro is challenging due to low spatiotemporal resolution and poor longevity of gradients utilizing microfluidic techniques. Here, we present a novel and simplistic approach for producing gradients of dissolved oxygen (DO) within a lab-on-a-chip platform. Linear and stable DO gradients with high spatial resolution are established by introducing pre-gassed media into the gradient generating network...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044135/long-term-toxicity-of-zno-nanoparticles-to-scenedesmus-rubescens-cultivated-in-different-media
#16
Andriana F Aravantinou, Fytoula Andreou, Ioannis D Manariotis
The aim of this work was to investigate the long-term toxic effect of zinc oxide (ZnO) nanoparticles (NPs) on freshwater microalgae, combined with the nutrient consumption in the culture. For this purpose, two common microalgae media (Blue-Green 11, BG-11, and Bold's Basal Medium, BBM) were used. Scenedesmus rubescens was used as freshwater microalgae model species and was exposed to ZnO NPs at different concentrations (0.081 to 810 mg/L) for a period up to 28 d. The experimental results revealed that microalgae growth was affected by the time of exposure and the NPs concentrations, but mainly the culture medium used...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043791/lyophilized-engineered-phages-for-escherichia-coli-detection-in-food-matrices
#17
Juhong Chen, Rachael A Picard, Danhui Wang, Sam R Nugen
Easy-to-use, low-cost, and convenient-of-transport are the key requirements for a commercial bacteria detection kit designed for resource-limited settings. Here, we report the colorimetric detection of Escherichia coli (E. coli) in food samples using freeze-dried engineered bacteriophages (phages). In this approach, we have engineered T7 phages to carry the lacZ operon driven by T7 promoter to overexpress reporter enzyme. The engineered phages were freeze-dried in a water-soluble polymer for storage and transportation...
October 18, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29043677/using-optical-tweezers-combined-with-total-internal-reflection-microscopy-to-study-interactions-between-the-er-and-golgi-in-plant-cells
#18
Imogen Sparkes, Rhiannon R White, Benjamin Coles, Stanley W Botchway, Andy Ward
Optical tweezers have been used to trap and micromanipulate several biological specimens ranging from DNA, macromolecules, organelles to single celled organisms. Using a combination of the refraction and scattering of laser light from a focused laser beam, refractile objects are physically captured and can be moved within the surrounding media. The technique is routinely used to determine biophysical properties such as the forces exerted by motor proteins. Here, we describe how optical tweezers combined with total internal reflection fluorescence (TIRF) microscopy can be used to assess physical interactions between organelles, more specifically the ER and Golgi bodies in plant cells...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29043647/the-cellclamper-a-convenient-microfluidic-device-for-time-lapse-imaging-of-yeast
#19
Gregor W Schmidt, Olivier Frey, Fabian Rudolf
Time-lapse fluorescence imaging of yeast cells allows the study of multiple fluorescent targets in single cells, but is often hampered by the tedious cultivation using agar pads or glass bottom wells. Here, we describe the fabrication and operation of a microfluidic device for long-term imaging of yeast cells under constant or changing media conditions. The device allows acquisition of high quality images as cells are fixed in a two-dimensional imaging plane. Four yeast strains can be analyzed simultaneously over several days while up to four different media can be flushed through the chip...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29043547/age-related-effects-of-bariatric-surgery-on-early-atherosclerosis-and-cardiovascular-risk-reduction
#20
Frederik H W Jonker, Vera A A van Houten, Leontine H Wijngaarden, René A Klaassen, André A E A de Smet, André Niezen, Lodewijk J D M Schelfhout, Tobias A Bruning, Erwin van der Harst
BACKGROUND: Carotid intima-media thickness (CIMT) is increasingly used as a prognostic indicator for early atherosclerosis and the development of cardiovascular disease. The objective of this study is to assess the exact effects of bariatric surgery on CIMT reduction in different age groups. METHODS: CIMT was measured just proximal to the bifurcation of the carotid artery in 166 patients with mean body mass index of 43.4 kg/m(2) before and at 6 and 12 months after bariatric surgery...
October 17, 2017: Obesity Surgery
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