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MRI perfusion brain

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https://www.readbyqxmd.com/read/29213008/the-relationship-between-neurite-density-measured-with-confocal-microscopy-in-a-cleared-mouse-brain-and-metrics-obtained-from-diffusion-tensor-and-diffusion-kurtosis-imaging
#1
Ryusuke Irie, Koji Kamagata, Aurelien Kerever, Ryo Ueda, Suguru Yokosawa, Yosuke Otake, Hisaaki Ochi, Hidekazu Yoshizawa, Ayato Hayashi, Kazuhiko Tagawa, Hitoshi Okazawa, Kohske Takahashi, Kanako Sato, Masaaki Hori, Eri Arikawa-Hirasawa, Shigeki Aoki
PURPOSE: Diffusional kurtosis imaging (DKI) enables sensitive measurement of tissue microstructure by quantifying the non-Gaussian diffusion of water. Although DKI is widely applied in many situations, histological correlation with DKI analysis is lacking. The purpose of this study was to determine the relationship between DKI metrics and neurite density measured using confocal microscopy of a cleared mouse brain. METHODS: One thy-1 yellow fluorescent protein 16 mouse was deeply anesthetized and perfusion fixation was performed...
December 7, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29197390/evaluation-of-b1-inhomogeneity-effect-on-dce-mri-data-analysis-of-brain-tumor-patients-at-3t
#2
Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh
BACKGROUND: Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1inh). The purpose of the study was to evaluate the effect of B1inh on quantitative analysis of DCE-MRI data of human brain tumor patients and to evaluate the clinical significance of B1inh correction of perfusion parameters (PPs) on tumor grading. METHODS: An MRI study was conducted on 35 glioma patients at 3T...
December 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29196191/arterial-spin-labeling-perfusion-mri-signal-denoising-using-robust-principal-component-analysis
#3
Hancan Zhu, Jian Zhang, Ze Wang
BACKGROUND: Arterial spin labeling (ASL) perfusion MRI provides a non-invasive way to quantify regional cerebral blood flow (CBF) and has been increasingly used to characterize brain state changes due to disease or functional alterations. Its use in dynamic brain activity study, however, is still hampered by the relatively low signal-to-noise-ratio (SNR) of ASL data. NEW METHOD: The aim of this study was to validate a new temporal denoising strategy for ASL MRI...
November 28, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29193406/online-1-h-mrs-measurements-of-time-varying-lactate-production-in-an-animal-model-of-glioma-during-administration-of-an-anti-tumoral-drug
#4
Yannick Crémillieux, Roberto Salvati, Ursule Dumont, Noël Pinaud, Véronique Bouchaud, Stéphane Sanchez, Stefan Glöggler, Alan Wong
The aims of this study were to implement a magnetic resonance spectroscopy (MRS) protocol for the online profiling of subnanomolar quantities of metabolites sampled from the extracellular fluid using implanted microdialysis and to apply this protocol in glioma-bearing rats for the quantification of lactate concentration and the measurement of time-varying lactate concentration during drug administration. MRS acquisitions on the brain microdialysate were performed using a home-built, proton-tuned, microsolenoid with an active volume of 2 μL...
November 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29190675/in-patients-with-suspected-acute-stroke-ct-perfusion-based-cerebral-blood-flow-maps-cannot-substitute-for-dwi-in-measuring-the-ischemic-core
#5
William A Copen, Albert J Yoo, Natalia S Rost, Lívia T Morais, Pamela W Schaefer, R Gilberto González, Ona Wu
BACKGROUND: Neuroimaging may guide acute stroke treatment by measuring the volume of brain tissue in the irreversibly injured "ischemic core." The most widely accepted core volume measurement technique is diffusion-weighted MRI (DWI). However, some claim that measuring regional cerebral blood flow (CBF) with CT perfusion imaging (CTP), and labeling tissue below some threshold as the core, provides equivalent estimates. We tested whether any threshold allows reliable substitution of CBF for DWI...
2017: PloS One
https://www.readbyqxmd.com/read/29184763/usefulness-of-enhancement-perfusion-mismatch-in-differentiation-of-cns-lymphomas-from-other-enhancing-malignant-tumors-of-the-brain
#6
Pradeep Goyal, Yogesh Kumar, Nishant Gupta, Ajay Malhotra, Saurabh Gupta, Sonali Gupta, Manisha Mangla, Rajiv Mangla
Background: Surgical planning and treatment options for primary or secondary central nervous system lymphomas (PCNSL or SCNSL) are different from other enhancing malignant lesions such as glioblastoma multiforme (GBM), anaplastic gliomas and metastases; so, it is critical to distinguish them preoperatively. We hypothesized that enhancement-perfusion (E-P) mismatch on dynamic susceptibility weighted magnetic resonance (DSC-MR) perfusion imaging which corresponds to low mean relative cerebral blood volume (mean rCBV) in an enhancing portion of the tumor should allow differentiation of CNS lymphomas from other enhancing malignant lesions...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29170485/aberrant-perfusion-and-its-connectivity-within-default-mode-network-of-first-episode-drug-na%C3%A3-ve-schizophrenia-patients-and-their-unaffected-first-degree-relatives
#7
Long-Biao Cui, Liu-Xian Wang, Ping Tian, Hua-Ning Wang, Min Cai, Fan Guo, Chen Li, Yu-Jing Wu, Peng-Gang Qiao, Zi-Liang Xu, Lin Liu, Hong He, Wen-Jun Wu, Yi-Bin Xi, Hong Yin
Neural substrates behind schizophrenia (SZ) and its heritability mediated by brain function are largely unknown. Cerebral blood flow (CBF), as a biomarker of activation in the brain, reflects the neuronal metabolism, and is promisingly used to detect cerebral alteration thereby shedding light on the features of individuals at high genetic risk. We performed a cross-sectional functional magnetic resonance imaging (MRI) study enrolling 45 first-episode drug-naïve patients with SZ, 32 unaffected first-degree relatives of these patients, and 51 healthy controls (HCs)...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29160952/transit-time-mapping-in-the-mouse-brain-using-time-encoded-pcasl
#8
Lydiane Hirschler, Leon P Munting, Artem Khmelinskii, Wouter M Teeuwisse, Ernst Suidgeest, Jan M Warnking, Louise van der Weerd, Emmanuel L Barbier, Matthias J P van Osch
The cerebral blood flow (CBF) is a potential biomarker for neurological disease. However, the arterial transit time (ATT) of the labeled blood is known to potentially affect CBF quantification. Furthermore, ATT could be an interesting biomarker in itself, as it may reflect underlying macro- and microvascular pathologies. Currently, no optimized magnetic resonance imaging (MRI) sequence exists to measure ATT in mice. Recently, time-encoded labeling schemes have been implemented in rats and humans, enabling ATT mapping with higher signal-to-noise ratio (SNR) and shorter scan time than multi-delay arterial spin labeling (ASL)...
November 21, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29157745/differential-diagnosis-of-parkinsonian-syndromes-using-dopamine-transporter-and-perfusion-spect
#9
Shigetoshi Takaya, Nobukatsu Sawamoto, Tomohisa Okada, Gosuke Okubo, Sei Nishida, Kaori Togashi, Hidenao Fukuyama, Ryosuke Takahashi
OBJECTIVE: We aimed to assess whether a combined analysis of dopamine transporter (DAT)- and perfusion-SPECT images (or either) could: (1) distinguish atypical parkinsonian syndromes (APS) from Lewy body diseases (LBD; majority Parkinson disease [PD]), and (2) differentiate among APS subgroups (progressive supranuclear palsy [PSP], corticobasal syndrome [CBS], and multiple system atrophy [MSA]). METHODS: We recruited consecutive patients with neurodegenerative parkinsonian syndromes (LBD, n = 46; APS, n = 33)...
November 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29155259/polyi-c-model-of-schizophrenia-in-rats-induces-functional-brain-changes-detected-by-mri-irreversible-by-aripiprazole-treatment
#10
Eva Drazanova, Jana Ruda-Kucerova, Lucie Kratka, Katerina Horska, Regina Demlova, Zenon Starcuk, Tomas Kasparek
BACKGROUND AND PURPOSE: One of the hallmarks of schizophrenia is altered brain structure, potentially due to antipsychotic treatment, the disorder itself or both. It was proposed that functional changes may precede the structural ones. In order to understand and potentially prevent this unwanted process, brain function assessment should be validated as a diagnostic tool. METHODS: We used Arterial Spin Labelling MRI technique for the evaluation of brain perfusion in several brain regions in a neurodevelopmental poly(I:C) model of schizophrenia (8 mg/kg on a gestational day 15) in rats taking into account sex-dependent effects and chronic treatment with aripiprazole (30 days), an atypical antipsychotic acting as a partial agonist on dopaminergic receptors...
November 16, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29154283/longitudinal-neuroimaging-analysis-in%C3%A2-mild-moderate-alzheimer-s-disease-patients-treated-with-plasma-exchange-with%C3%A2-5-human-albumin
#11
Gemma Cuberas-Borrós, Isabel Roca, Mercè Boada, Lluís Tárraga, Isabel Hernández, Mar Buendia, Lourdes Rubio, Gustavo Torres, Ángel Bittini, Juan A Guzmán-de-Villoria, Francesc Pujadas, Mireia Torres, Laura Núñez, Joan Castell, Antonio Páez
BACKGROUND: Recently, modifications of Aβ1-42 levels in CSF and plasma associated with improvement in memory and language functions have been observed in patients with mild-moderate Alzheimer's disease (AD) treated with plasma exchange (PE) with albumin replacement. OBJECTIVE: To detect structural and functional brain changes in PE-treated AD patients as part of a Phase II clinical trial. METHODS: Patients received between 3 and 18 PE with albumin (Albutein® 5%, Grifols) or sham-PE (controls) for 21 weeks (divided in one intensive and two maintenance periods) followed by 6-month follow-up...
November 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29151054/effect-of-ephedrine-and-phenylephrine-on-brain-oxygenation-and-microcirculation-in-anaesthetised-patients-with-cerebral-tumours-study-protocol-for-a-randomised-controlled-trial
#12
Klaus Ulrik Koch, Anna Tietze, Joel Aanerud, Gorm von Öettingen, Niels Juul, Jens Christian Hedemann Sørensen, Lone Nikolajsen, Leif Østergaard, Mads Rasmussen
INTRODUCTION: During brain tumour surgery, vasopressor drugs are commonly administered to increase mean arterial blood pressure with the aim of maintaining sufficient cerebral perfusion pressure. Studies of the commonly used vasopressors show that brain oxygen saturation is reduced after phenylephrine administration, but unaltered by ephedrine administration. These findings may be explained by different effects of phenylephrine and ephedrine on the cerebral microcirculation, in particular the capillary transit-time heterogeneity, which determines oxygen extraction efficacy...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146191/automatic-delineation-of-brain-regions-on-mri-and-pet-images-from-the-pig
#13
Jonas Villadsen, Hanne D Hansen, Louise M Jørgensen, Sune H Keller, Flemming L Andersen, Ida N Petersen, Gitte M Knudsen, Claus Svarer
BACKGROUND: The increasing use of the pig as a research model in neuroimaging requires standardized processing tools. For example, extraction of regional dynamic time series from brain PET images requires parcellation procedures that benefit from being automated. COMPARISON WITH EXISTING METHODS: Manual inter-modality spatial normalization to a MRI atlas is operator-dependent, time-consuming, and can be inaccurate with lack of cortical radiotracer binding or skull uptake...
November 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29145285/degeneration-of-paramedian-nuclei-in-the-thalamus-induces-holmes-tremor-in-a-case-of-artery-of-percheron-infarction
#14
Tz-Shiang Wei, Chun-Sheng Hsu, Yu-Chun Lee, Shin-Tsu Chang
RATIONALE: Holmes' tremor is an uncommon neurologic disorder following brain insults, and its pathogenesis is undefined. The interruption of the dento-rubro-thalamic tract and secondary deterioration of the nigrostriatal pathway are both required to initiate Holmes' tremor. We used nuclear medicine imaging tools to analyze a patient with concurrent infarction in different zones of each side of the thalamus. Finding whether the paramedian nuclear groups of the thalamus were injured was a decisive element for developing Holmes' tremor...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136305/neural-basis-of-exertional-fatigue-in-the-heat-a-review-of-magnetic-resonance-imaging-methods
#15
REVIEW
X R Tan, Ivan C C Low, Mary C Stephenson, T W Soong, Jason K W Lee
The central nervous system, specifically the brain, is implicated in the development of exertional fatigue under a hot environment. Diverse neuroimaging techniques have been used to visualize the brain activity during or after exercise. Notably, the use of magnetic resonance imaging (MRI) has become prevalent due to its excellent spatial resolution and versatility. This review evaluates the significance and limitations of various brain MRI techniques in exercise studies - brain volumetric analysis, functional MRI, functional connectivity MRI and arterial spin labelling...
November 14, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29128467/volumetric-response-of-the-adult-brain-to-seizures-depends-on-the-developmental-stage-when-systemic-inflammation-was-induced
#16
Krzysztof Janeczko, Emilia Kosonowska, Artur Kiepura, Wladyslaw Weglarz, Zuzanna Setkowicz
Inflammation has detrimental influences on the developing brain including triggering the epileptogenesis. On the other hand, seizure episodes may induce inflammatory processes and further increase of brain excitability. The present study focuses on the problem whether transitory systemic inflammation during developmental period may have critical importance to functional and/or structural features of the adult brain. An inflammatory status was induced with lipopolysaccharide (LPS) in 6- or 30-day-old rats. Two-month-old rats which experienced the inflammation and untreated controls received injections of pilocarpine, and the intensity of their seizure behavior was rated during a 6-hour period...
November 8, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29117709/detecting-perfusion-pattern-based-on-the-background-low-frequency-fluctuation-in-resting-state-functional-mri-data-and-its-influence-on-resting-state-networks-an-iterative-post-processing-approach
#17
Tianyi Qian, Davide Zanchi, Cristelle Rodriguez, Marine Ackermann, Panteleimon Giannakopoulos, Sven Haller
INTRODUCTION: RS-fMRI is based on the assumption that the vascular response and the blood oxygenation level dependent (BOLD) response are homogenous across the entire brain. However, this a priori hypothesis is not consistent with the well-known variability of cerebral vascular territories. In order to explore whether the RS networks are influenced by varied vascular speed in different vascular territories, we assessed the time-shift maps that give an estimate of the local timing of the vascular response and check whether local differences in this timing have an impact on the estimates of RS networks...
November 8, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/29114921/association-of-early-left-ventricular-dysfunction-with-advanced-magnetic-resonance-white-matter-and-gray-matter-brain-measures-the-cardia-study
#18
Anderson C Armstrong, Majon Muller, Bharath Ambale-Ventakesh, Michael Halstead, Satoru Kishi, Nick Bryan, Stephen Sidney, Luís C L Correia, Samuel S Gidding, Lenore J Launer, João A C Lima
INTRODUCTION: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. AIMS: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. METHODS: The CARDIA study enrolled 5115 young adults aged 18-30 years at baseline (1985-1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010-2011)...
November 8, 2017: Echocardiography
https://www.readbyqxmd.com/read/29106751/fast-na-k-pump-driven-steady-state-transcytolemmal-water-exchange-in-neuronal-tissue-a-study-of-rat-brain-cortical-cultures
#19
Ruiliang Bai, Charles S Springer, Dietmar Plenz, Peter J Basser
PURPOSE: Water homeostasis and transport play important roles in brain function (e.g., ion homeostasis, neuronal excitability, cell volume regulation, etc.). However, specific mechanisms of water transport across cell membranes in neuronal tissue have not been completely elaborated. METHODS: The kinetics of transcytolemmal water exchange were measured in neuronal tissue using simultaneous, real-time fluorescence and nuclear magnetic resonance (NMR) measurements of perfused, active brain organotypic cortical cultures...
November 6, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29104740/cerebellum-and-neurodegenerative-diseases-beyond-conventional-magnetic-resonance-imaging
#20
REVIEW
Enricomaria Mormina, Maria Petracca, Giulia Bommarito, Niccolò Piaggio, Sirio Cocozza, Matilde Inglese
The cerebellum plays a key role in movement control and in cognition and cerebellar involvement is described in several neurodegenerative diseases. While conventional magnetic resonance imaging (MRI) is widely used for brain and cerebellar morphologic evaluation, advanced MRI techniques allow the investigation of cerebellar microstructural and functional characteristics. Volumetry, voxel-based morphometry, diffusion MRI based fiber tractography, resting state and task related functional MRI, perfusion, and proton MR spectroscopy are among the most common techniques applied to the study of cerebellum...
October 28, 2017: World Journal of Radiology
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