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Magnetic resonance spectroscopy

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https://www.readbyqxmd.com/read/28231145/recent-advances-in-techniques-for-starch-esters-and-the-applications-a-review
#1
REVIEW
Jing Hong, Xin-An Zeng, Charles S Brennan, Margaret Brennan, Zhong Han
Esterification is one of the most important methods to alter the structure of starch granules and improve its applications. Conventionally, starch esters are prepared by conventional or dual modification techniques, which have the disadvantages of being expensive, have regent overdoses, and are time-consuming. In addition, the degree of substitution (DS) is often considered as the primary factor in view of its contribution to estimate substituted groups of starch esters. In order to improve the detection accuracy and production efficiency, different detection techniques, including titration, nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis/infrared spectroscopy (TGA/IR) and headspace gas chromatography (HS-GC), have been developed for DS...
July 9, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231139/evaluation-of-the-bitterness-masking-effect-of-powdered-roasted-soybeans
#2
Yoshimasa Makita, Tomoko Ishida, Noriko Kobayashi, Mai Fujio, Kyoko Fujimoto, Rina Moritomo, Jun-Ichi Fujita, Shin-Ichi Fujiwara
The masking of bitterness is considered important because many pharmaceutical compounds have a bitter taste. The bitterness-masking effect of powdered roasted soybeans (PRS) was investigated using a bitter taste sensor. PRS was revealed to significantly suppress the bitterness of quinine hydrochloride and denatonium benzoate. Furthermore, the bitterness-masking mechanism of PRS extracts was evaluated using dynamic light scattering. These results showed that the extracted suspension consisted of particles that were several hundreds of nanometers in size...
June 18, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230816/new-route-synthesis-of-thiadiazoles-bisthiadiazoles-thiadiazolotriazines-and-pyrazolothiadiazoles-based-on-hydrazonoyl-halides-and-dihydrazinylthiadiazole
#3
Abdelwahed R Sayed, Shar Saad Al-Shihry
Synthesis and characterization of new thiadiazoles, bisthiadiazoles from the reaction of mono- and di-hydrazonoyl halides with various hydrazinecarbodithioate derivatives were studied. Treatment of hydrazonoyl halides with 2,5-dihydrazinyl-1,3,4-thiadiazole afforded new bistriazines containing thiadiazole; we also examined the reaction of 2,5-dihydrazinyl-1,3,4-thiadiazole with active methylene compounds to afford new pyrazoles containing thiadiazole compounds. The new synthesized compounds were identified by elemental analysis and various spectral data (Fourier transform infrared spectroscopy, mass spectrometry, 1H and 13C nuclear magnetic resonance)...
February 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230201/relapsing-remitting-multiple-sclerosis-patients-display-an-altered-lipoprotein-profile-with-dysfunctional-hdl
#4
Winde Jorissen, Elien Wouters, Jeroen F Bogie, Tim Vanmierlo, Jean-Paul Noben, Denis Sviridov, Niels Hellings, Veerle Somers, Roland Valcke, Bart Vanwijmeersch, Piet Stinissen, Monique T Mulder, Alan T Remaley, Jerome J A Hendriks
Lipoproteins modulate innate and adaptive immune responses. In the chronic inflammatory disease multiple sclerosis (MS), reports on lipoprotein level alterations are inconsistent and it is unclear whether lipoprotein function is affected. Using nuclear magnetic resonance (NMR) spectroscopy, we analysed the lipoprotein profile of relapsing-remitting (RR) MS patients, progressive MS patients and healthy controls (HC). We observed smaller LDL in RRMS patients compared to healthy controls and to progressive MS patients...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230173/a-novel-physiological-role-for-cardiac-myoglobin-in-lipid-metabolism
#5
Ulrike B Hendgen-Cotta, Sonja Esfeld, Cristina Coman, Robert Ahrends, Ludger Klein-Hitpass, Ulrich Flögel, Tienush Rassaf, Matthias Totzeck
Continuous contractile activity of the heart is essential and the required energy is mostly provided by fatty acid (FA) oxidation. Myocardial lipid accumulation can lead to pathological responses, however the underlying mechanisms remain elusive. The role of myoglobin in dioxygen binding in cardiomyocytes and oxidative skeletal muscle has widely been appreciated. Our recent work established myoglobin as a protector of cardiac function in hypoxia and disease states. We here unravel a novel role of cardiac myoglobin in governing FA metabolism to ensure the physiological energy production through β-oxidation, preventing myocardial lipid accumulation and preserving cardiac functions...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229920/in-vitro-wound-healing-and-cytotoxic-activity-of-the-gel-and-whole-leaf-materials-from-selected-aloe-species
#6
Lizelle T Fox, Anisha Mazumder, Anupma Dwivedi, Minja Gerber, Jeanetta du Plessis, Josias H Hamman
ETHNOPHARMACOLOGICAL RELEVANCE: Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ferox and Aloe marlothii are used as traditional medicines for different applications. Although wound healing has been shown for certain aloe gel materials (e.g. A. vera) previously, there are conflicting reports on this medicinal application of aloe leaf gel materials...
February 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28229840/-magnetic-resonance-imaging-conversion-predictors-of-clinically-isolated-syndrome-to-multiple-sclerosis
#7
REVIEW
Sara Peixoto, Pedro Abreu
INTRODUCTION: Clinically isolated syndrome may be the first manifestation of multiple sclerosis, a chronic demyelinating disease of the central nervous system, and it is defined by a single clinical episode suggestive of demyelination. However, patients with this syndrome, even with long term follow up, may not develop new symptoms or demyelinating lesions that fulfils multiple sclerosis diagnostic criteria. We reviewed, in clinically isolated syndrome, what are the best magnetic resonance imaging findings that may predict its conversion to multiple sclerosis...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28228011/spectroscopic-definition-of-the-cuz-o-intermediate-in-turnover-of-nitrous-oxide-reductase-and-molecular-insight-into-the-catalytic-mechanism
#8
Esther M Johnston, Cíntia Carreira, Simone Dell'Acqua, Somdatta Ghosh Dey, Sofia R Pauleta, Isabel Moura, Edward I Solomon
Spectroscopic methods and density functional theory (DFT) calculations are used to determine the geometric and electronic structure of CuZ(o), an intermediate form of the Cu4S active site of nitrous oxide reductase (N2OR) that is observed in single turnover of fully reduced N2OR with N2O. Electron paramagnetic resonance (EPR), absorption, and magnetic circular dichroism (MCD) spectroscopies show that CuZ(o) is a 1-hole (i.e. 3Cu(I)Cu(II)) state with spin density delocalized evenly over CuI and CuIV. Resonance Raman spectroscopy shows two Cu-S vibrations at 425 and 413 cm(-1), the latter with a -3 cm(-1) O(18) solvent isotope shift...
February 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28227941/a-three-element-1-h-31-p-dual-tuned-array-for-magnetic-resonance-spectroscopy-at-4-7-t
#9
Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall, Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall, Jeremy Sia, Romina Del Bosque, Kurt Parizek, Mary P McDougall, Matthew D Wilcox, Edwin D Eigenbrodt
This work describes the construction and testing of a three-element, double-tuned receive array and transmit coils for (31)P-(1)H spectroscopy and imaging. The receive coils were geometrically-decoupled, single-loop surface coils and the transmit coils were concentric saddle coils. The coils were used to examine a physiologically-modeled CNC-milled phantom. The receive coil array was able to improve SNR while also providing gross localization of the (1)H and (31)P signals.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227196/low-cost-and-efficient-kurtosis-based-deflationary-ica-method-application-to-mrs-sources-separation-problem
#10
M Saleh, A Karfoul, A Kachenoura, L Senhadji, L Albera, M Saleh, A Karfoul, A Kachenoura, L Senhadji, L Albera, L Albera, L Senhadji, A Kachenoura, M Saleh, A Karfoul
Improving the execution time and the numerical complexity of the well-known kurtosis-based maximization method, the RobustICA, is investigated in this paper. A Newton-based scheme is proposed and compared to the conventional RobustICA method. A new implementation using the nonlinear Conjugate Gradient one is investigated also. Regarding the Newton approach, an exact computation of the Hessian of the considered cost function is provided. The proposed approaches and the considered implementations inherit the global plane search of the initial RobustICA method for which a better convergence speed for a given direction is still guaranteed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225611/magneto-structural-correlations-in-pseudotetrahedral-forms-of-the-co-sph-4-2-complex-probed-by-magnetometry-mcd-spectroscopy-advanced-epr-techniques-and-ab-initio-electronic-structure-calculations
#11
Elizaveta A Suturina, Joscha Nehrkorn, Joseph M Zadrozny, Junjie Liu, Mihail Atanasov, Thomas Weyhermüller, Dimitrios Maganas, Stephen Hill, Alexander Schnegg, Eckhard Bill, Jeffrey R Long, Frank Neese
The magnetic properties of pseudotetrahedral Co(II) complexes spawned intense interest after (PPh4)2[Co(SPh)4] was shown to be the first mononuclear transition-metal complex displaying slow relaxation of the magnetization in the absence of a direct current magnetic field. However, there are differing reports on its fundamental magnetic spin Hamiltonian (SH) parameters, which arise from inherent experimental challenges in detecting large zero-field splittings. There are also remarkable changes in the SH parameters of [Co(SPh)4](2-) upon structural variations, depending on the counterion and crystallization conditions...
February 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28225576/3d-multiecho-dixon-for-the-evaluation-of-hepatic-iron-and-fat-in-a-clinical-setting
#12
Benjamin Henninger, Heinz Zoller, Stephan Kannengiesser, Xiaodong Zhong, Werner Jaschke, Christian Kremser
PURPOSE: To prospectively evaluate a new 3D-multiecho-Dixon (3D-ME-Dixon) sequence for the quantification of hepatic iron and fat in a clinical setting. MATERIALS AND METHODS: In all, 120 patients underwent 1.5T magnetic resonance imaging of the liver between December 2013 and June 2015 including the following three sequences: 3D-ME-Dixon with inline calculation of R2* and proton-density fat-fraction (PDFF) maps, single-voxel-spectroscopy (SVS), 2D multigradient-echo sequence (2D-ME-GRE)...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225569/hepatic-alanine-differentiates-nonalcoholic-steatohepatitis-from-simple-steatosis-in-humans-and-mice-a-proton-mr-spectroscopy-study-with-long-echo-time
#13
Tae-Hoon Kim, Hong Young Jun, Ki-Jong Kim, Young Hwan Lee, Myeung Su Lee, Keum Ha Choi, Ki Jung Yun, Yong Yeon Jeong, Chung Hwan Jun, Eun Young Cho, Kwon-Ha Yoon
PURPOSE: To evaluate the hepatic metabolic alterations in nonalcoholic fatty liver disease (NAFLD) by using (1) H-MRS (proton magnetic resonance spectroscopy) with long echo time and to test the reproducibility of human study in an animal model. Liver biopsy is the gold standard for diagnosing NAFLD but with practical constraints. (1) H-MRS allows in vivo assessment of hepatocellular metabolism and has shown potential for biochemical differentiation in diffuse liver disease. MATERIALS AND METHODS: In all, 32 subjects (11 patients with nonalcoholic steatohepatitis [NASH], 15 with simple steatosis [SS], and six healthy controls) were studied...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225186/randomised-clinical-trial-the-efficacy-and-safety-of-oltipraz-a-liver-x-receptor-alpha-inhibitory-dithiolethione-in-patients-with-non-alcoholic-fatty-liver-disease
#14
W Kim, B G Kim, J S Lee, C K Lee, J E Yeon, M S Chang, J H Kim, H Kim, S Yi, J Lee, J-Y Cho, S G Kim, J-H Lee, Y J Kim
BACKGROUND: Oltipraz is a synthetic dithiolethione with an antisteatotic effect by inhibiting the activity of liver X receptor alpha (LXR-α). Recent studies demonstrated the disruptive role of oltipraz on LXR-α-dependent lipogenesis in hepatocytes and a high-fat diet mouse model. AIM: To evaluate the efficacy and safety of oltipraz for reducing liver fat in subjects with non-alcoholic fatty liver disease (NAFLD). METHODS: We performed a multicentre, double-blind, placebo-controlled, phase II study...
February 22, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28224913/parent-heparin-and-daughter-lmw-heparin-correlation-analysis-using-lc-ms-and-nmr
#15
Xinyue Liu, Kalib St Ange, Xiaohua Wang, Lei Lin, Fuming Zhang, Lianli Chi, Robert J Linhardt
Heparin is a structurally complex, polysaccharide anticoagulant derived from livestock, primarily porcine intestinal tissues. Low molecular weight (LMW) heparins are derived through the controlled partial depolymerization of heparin. Increased manufacturing and regulatory concerns have provided the motivation for the development of more sophisticated analytical methods for determining both their structure and pedigree. A strategy, for the comprehensive comparison of parent heparins and their LMW heparin daughters, is described that relies on the analysis of monosaccharide composition, disaccharide composition, and oligosaccharide composition...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224195/paenibacillus-sp-598k-6-%C3%AE-glucosyltransferase-is-essential-for-cycloisomaltooligosaccharide-synthesis-from-%C3%AE-1%C3%A2-%C3%A2-%C3%A2-4-glucan
#16
Hitomi Ichinose, Ryuichiro Suzuki, Takatsugu Miyazaki, Keitarou Kimura, Mitsuru Momma, Nobuhiro Suzuki, Zui Fujimoto, Atsuo Kimura, Kazumi Funane
Paenibacillus sp. 598K produces cycloisomaltooligosaccharides (cyclodextrans) from starch even in the absence of dextran. Cycloisomaltooligosaccharide glucanotransferase synthesizes cycloisomaltooligosaccharides exclusively from an α-(1 → 6)-consecutive glucose chain consisting of at least four molecules. Starch is not a substrate of this enzyme. Therefore, we predicted that the bacterium possesses another enzyme system for extending α-(1 → 6)-linked glucoses from starch, which can be used as the substrate for cycloisomaltooligosaccharide glucanotransferase, and identified the transglucosylation enzyme Ps6GT31A...
February 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28223120/supramolecular-formulation-of-nitidine-chloride-can-alleviate-its-hepatotoxicity-and-improve-its-anticancer-activity
#17
Wanying Li, Hang Yin, David Bardelang, Jianbo Xiao, Ying Zheng, Ruibing Wang
Nitidine chloride (NC) has demonstrated promising anticancer activity. However, NC has also shown non-specific toxicity in various healthy organs such as the liver. In this study, we aimed to develop a supramolecular formulation for NC and investigate the associated benefits of such a supramolecular formulation on modulating its inherent hepatotoxicity and anticancer activity. The formation of NC-cucurbit[7]uil (NC@CB[7]) complexes was characterized by (1)H nuclear magnetic resonance and Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffraction analysis...
February 18, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28222355/neuroimaging-of-major-depression-in-parkinson-s-disease-cortical-thickness-cortical-and-subcortical-volume-and-spectroscopy-findings
#18
Marcos Hortes N Chagas, Vitor Tumas, Márcio A Pena-Pereira, João Paulo Machado-de-Sousa, Antonio Carlos Dos Santos, Rafael Faria Sanches, Jaime E C Hallak, José Alexandre S Crippa
Depression is the most common psychiatric disorder in Parkinson's disease (PD). The aim of this study was to compare PD patients with current Major Depressive Disorder (MDD), lifetime MDD, and no MDD using three neuroimaging techniques. A total of 43 PD patients were selected and divided into three groups: (i) current MDD (n = 15), (ii) previous MDD without current MDD (n = 10); and (iii) control group (no current or lifetime MDD; n = 18). All participants underwent magnetic resonance imaging to evaluate cortical thickness, cortical and subcortical volume, and spectroscopy in the bilateral putamen and cingulate cortex...
February 13, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28221786/chemical-trends-in-solid-alkali-pertechnetates
#19
Jamie Weaver, Chuck Z Soderquist, Nancy M Washton, Andrew S Lipton, Paul L Gassman, Wayne W Lukens, Albert A Kruger, Nathalie A Wall, John S McCloy
Insight into the solid-state chemistry of pure technetium-99 ((99)Tc) oxides is required in the development of a robust immobilization and disposal system for nuclear waste stemming from the radiopharmaceutical industry, from the production of nuclear weapons, and from spent nuclear fuel. However, because of its radiotoxicity and the subsequent requirement of special facilities and handling procedures for research, only a few studies have been completed, many of which are over 20 years old. In this study, we report the synthesis of pure alkali pertechnetates (sodium, potassium, rubidium, and cesium) and analysis of these compounds by Raman spectroscopy, X-ray absorption spectroscopy (XANES and EXAFS), solid-state nuclear magnetic resonance (static and magic angle spinning), and neutron diffraction...
February 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28220878/homozygous-carriers-of-the-tcf7l2-rs7903146-t-allele-show-altered-postprandial-response-in-triglycerides-and-triglyceride-rich-lipoproteins
#20
L Engelbrechtsen, T H Hansen, Y Mahendran, P Pyl, E Andersson, A Jonsson, A Gjesing, A Linneberg, T Jørgensen, T Hansen, H Vestergaard
The TCF7L2 rs7903146 T-allele shows the strongest association with type 2 diabetes (T2D) among common gene variants. The aim of this study was to assess circulating levels of metabolites following a meal test in individuals carrying the high risk rs790346 TT genotype (cases) and low-risk CC genotype (controls). Sixty-two men were recruited based on TCF7L2 genotype, 31 were TT carriers and 31 were age- and BMI-matched CC carriers. All participants consumed a test meal after 12 hours of fasting. Metabolites were measured using proton nuclear magnetic resonance (NMR) spectroscopy...
February 21, 2017: Scientific Reports
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