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https://www.readbyqxmd.com/read/28516842/serotype-distribution-antimicrobial-resistance-and-prevalence-of-pilus-islets-in-pneumococci-following-the-use-of-conjugate-vaccines
#1
Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi
PURPOSE: In Japan, the 7-valent pneumococcal vaccine (PCV7) was introduced in 2010 and, in 2013, the PCV7 was replaced with the 13-valent pneumococcal vaccine (PCV13). This study was conducted to investigate serotypes, antimicrobial resistance and prevalence of pilus islets in pneumococcal isolates from inpatients in a Japanese tertiary hospital. METHODOLOGY: From April 2011 to February 2016, 151 isolates [95 (18 children, 77 adults) and 56 (19 children, 37 adults) in the PCV7 and PCV13 periods, respectively] were collected...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28505422/oxygen-sensing-with-perfluorocarbon-loaded-ultraporous-mesostructured-silica-nanoparticles
#2
Amani L Lee, Clifford T Gee, Bradley P Weegman, Samuel A Einstein, Adam R Juelfs, Hattie L Ring, Katie R Hurley, Sam M Egger, Garrett Swindlehurst, Michael G Garwood, William C K Pomerantz, Christy L Haynes
Oxygen homeostasis is important in the regulation of biological function. Disease progression can be monitored by measur-ing oxygen levels, thus producing information for the design of therapeutic treatments. Non-invasive measurements of tissue oxygenation require the development of tools with minimal adverse effects and facile detection of features of interest. Fluo-rine magnetic resonance imaging (19F-MRI) exploits the intrinsic properties of perfluorocarbon (PFC) liquids for anatomical imaging, cell tracking, and oxygen sensing...
May 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28498638/assessing-the-influence-of-mutation-on-gtpase-transition-states-using-x-ray-19f-nmr-and-dft-approaches
#3
Jonathan P Waltho, Yi Jin, Robert W Molt, Erika Pellegrini, Matthew J Cliff, Matthew W Bowler, Nigel G J Richards, G Michael Blackburn
We report X-ray crystallographic and 19F NMR studies of RhoA complexed with MgF3-, GDP, and RhoGAP having the mutation Arg85'Ala, which, when combined with DFT calculations, permit the identification of changes in TS properties. Thus, X-ray shows how Tyr34 maintains solvent exclusion and the core H-bond network in the active site by relocating to replace the missing Arg85' sidechain. 19F NMR data show deshielding effects that indicate the main function of Arg85´ is electronic polarization of the transferring phosphoryl group, primarily mediated by H-bonding to O3G and thence to PG...
May 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28495356/scleral-topography-analysed-by-optical-coherence-tomography
#4
Stefan Bandlitz, Joachim Bäumer, Uwe Conrad, James Wolffsohn
PURPOSE: A detailed evaluation of the corneo-scleral-profile (CSP) is of particular relevance in soft and scleral lenses fitting. The aim of this study was to use optical coherence tomography (OCT) to analyse the profile of the limbal sclera and to evaluate the relationship between central corneal radii, corneal eccentricity and scleral radii. METHODS: Using OCT (Optos OCT/SLO; Dunfermline, Scotland, UK) the limbal scleral radii (SR) of 30 subjects (11M, 19F; mean age 23...
May 8, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28474530/electronic-properties-of-triazoles-experimental-and-computational-determination-of-carbocation-and-radical-stabilizing-properties
#5
Xavier Creary, Kyle Chormanski, Gabriel Peirats, Carol Renneburg
Three fluorobenzenes substituted with meta-triazole groups have been prepared and 19F chemical shifts indicate that these triazole groups are all inductively electron-withdrawing in character, with the 1,5-triazole being the most electron-withdrawing. σ+ values for these three triazoles have also been determined from solvolysis rates of substituted cumyl trifluoroacetates. When substituted in the para-position, the 1,4 and the 2,4-triazoles are cation stabilizing, while the 1,5-triazole is carbocation destabilizing...
May 5, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28472614/serotype-changes-and-antimicrobial-nonsusceptibility-rates-of-invasive-and-non-invasive-streptococcus-pneumoniae-isolates-after-implementation-of-10-valent-pneumococcal-nontypeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv-in-bulgaria
#6
Lena Setchanova, Marianna Murdjeva, Iglika Stancheva, Alexandra Alexandrova, Maria Sredkova, Temenuga Stoicheva, Magda Yoneva, Anna Kurchatova, Ivan Mitov
The 10-valent pneumococcal conjugate vaccine (PCV10) has been included in Bulgarian Childhood Immunization Program since 2010. This study aimed to assess serotype distribution and antimicrobial resistance of 198 invasive and non-invasive Streptococcus pneumoniae strains that had been isolated in Bulgaria during 2011-2016 from patients with invasive (IPD) and non-invasive (NIPD) pneumococcal diseases. The most common invasive serotypes were 3 (10.1%), 19F (4.0%), and 7F (3.0%). A significant decrease in the proportion of invasive vaccine types (VTs) from 64...
May 1, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28463461/bis-6-methylene-2-2-bipyridine-phenyl-phosphine-a-flexible-ligand-for-the-construction-of-trinuclear-coinage-metal-complexes
#7
Peter Werner Roesky, Sebastian Schäfer, Michael T Gamer, Sergei Lebedkin, Florian Weigend, Manfred M Kappes
Bis-(6-methylene-2,2'-bipyridine)phenylphosphine (PN4) was designed as a tailor-made ligand with different metal binding sites (N and P) to support metallophilic interactions between the different coinage metals, as these are far less common than homometallic interactions, typically between gold(I) cations. Furthermore, the phosphorus(V)sulfide derivative of PN4 was synthesized to get additional structural information in the solid state. Two mononuclear gold complexes [(PN4)AuCl] and [(PN4)2Au][ClO4] were synthesized first...
May 2, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28453533/periodic-cycles-of-pneumococcal-serotypes-carried-by-children-before-and-after-7-valent-pneumococcal-conjugate-vaccine
#8
Ana Cristina Paulo, Raquel Sá-Leão
BACKGROUND: Periodic cycles in the serotype-specific incidence of invasive pneumococcal disease have been described but less is known in carriage. METHODS: We analyzed serotype carriage prevalence among children 0-6 years old over a 15-year period that included pre-PCV7 data and a decade of PCV7 use. Mixed generalized additive models were used to study periodic cycles and how PCV7 impacted on them. RESULTS: Pneumococcal carriage data of 7,463 children were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28444920/synthesis-of-mono-bis-and-tris-pentafluoroethyl-tin-derivatives-c2f5-4-nsnxn-x-ph-me-cl-br-cp-n%C3%A2-%C3%A2-1-3
#9
Johannes Klösener, Markus Wiesemann, Mark Niemann, Beate Neumann, Hans-Georg Stammler, Berthold Hoge
For (pentafluoroethyl)phenylstannanes, (C2F5)4-nSnPhn (n = 1-3), and dimethylbis(pentafluoroethyl)stannane, (C2F5)2SnMe2, a high yield synthesis was developed by the use of LiC2F5 as a C2F5 transfer reagent. The treatment of these products with gaseous hydrogen chloride or hydrogen bromide afforded (C2F5)4-nSnXn (X = Cl, Br; n = 1-3) in good yields. The (pentafluoroethyl)stannanes were fully characterized by 1H, 13C, 19F and 119Sn NMR, IR spectroscopy and mass spectrometry. The treatment of the (pentafluoroethyl)tin halides (C2F5)4-nSnXn with 1,10-phenanthroline (phen) led to the formation of the corresponding octahedrally coordinated complexes [(C2F5)4-nSnXn(phen)], the structures of which were elucidated by X-ray diffraction analyses...
April 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28427991/impact-of-the-pneumococcal-conjugate-vaccine-on-serotype-distribution-of-adult-non-invasive-streptococcus-pneumoniae-isolates-in-tokai-region-japan-2008-2016
#10
Yuri Furuya, Yuka Yamagishi, Hayato Okade, Takumi Kadota, Tori Funatsu, Maki Eto, Nobuhiko Nomura, Junichi Mitsuyama, Hiroshige Mikamo
The introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in February 2010 markedly reduced the burden of invasive pneumococcal disease and changed serotype distribution in Japan. In November 2013, PCV7 was replaced by the 13-valent pneumococcal conjugate vaccine (PCV13). We investigated the serotype distribution and susceptibility trends of non-invasive Streptococcus pneumoniae isolates collected from adult patients. A total of 504 pneumococcal isolates were collected during 4 periods between 2008 and 2016 (Period 1; between June 2008 and April 2009, Period 2; between September 2010 and March 2011, Period 3; between October 2011 and March 2012, Period 4; between August 2015 and January 2016)...
April 17, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28419083/pneumococcal-vaccination-and-efficacy-in-patients-with-heterotaxy-syndrome
#11
Pei-Lan Shao, Mei-Hwan Wu, Jou-Kou Wang, Hui-Wen Hsu, Li-Min Huang, Shuenn-Nan Chiu
BACKGROUND: Pneumococcal vaccines, including pneumococcal polysaccharide vaccine (PPV) and pneumococcal conjugated vaccine (PCV), are important in preventing invasive pneumococcal disease. We analyzed the pneumococcal vaccination rate, efficacy and durability in patients with heterotaxy. METHODS: All patients with heterotaxy and CCHD who were followed at our institution between 2010 and 2015 were included. Pneumococcal vaccine status and geometric mean concentration (GMC) of serotypes 6B, 14, 19F, and 23F were analyzed...
April 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28404574/parasitic-infections-in-pregnancy-decrease-placental-transfer-of-anti-pneumococcal-antibodies
#12
Noah D McKittrick, David M Vu, Indu Malhotra, Charles H King, Francis Mutuku, A Desiree LaBeaud
Many factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. However, little is known about the effect of maternal parasitic infection on placental antibody transfer. To investigate this, we selected, from a parent study of 576 pregnant Kenyan women, four groups of women with term deliveries (≥37 weeks), including uninfected women (N=30) and women with solo infections of malaria (N=30), hookworm (N=30), or schistosomiasis (N=10)...
April 12, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28403047/risk-factors-in-children-older-than-5-years-with-pneumococcal-meningitis-data-from-a-national-network
#13
Fanny Hénaff, Corinne Levy, Robert Cohen, Capucine Picard, Emmanuelle Varon, Christèle Gras Le Guen, Elise Launay
BACKGROUND: The occurrence of meningitis in children >5 years old may be associated with specific predisposing factors that can be anatomic, such as cerebrospinal fluid fistula or breach, or related to genetic susceptibility or N inborn or acquired immunologic defect. This study aimed to assess the anatomical and immunologic risk factors in children >5 years old with pneumococcal meningitis and prospectively enrolled in the French national meningitis network. METHODS: We analyzed all data for children who were 5-15 years old with a diagnosis of pneumococcal meningitis between 2001 and 2013...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28397940/phenotypic-and-molecular-study-of-pneumococci-causing-respiratory-tract-infections-a-3-year-prospective-cohort
#14
Amani M Alnimr, Maha Farhat
To study serotype distribution and antimicrobial resistance to beta-lactams and macrolides in pneumococci causing respiratory diseases after the introduction of the 13-valent pneumococcal conjugate vaccine in Saudi Arabia. Methods: This is a hospital-based and a cross-sectional prospective surveillance study conducted at King Fahad Hospital of the University, AlKhobar, Kingdom  of Saudi Arabia, in which respiratory pneumococcal isolates collected between 2012 and 2014 were serotyped by multiplex sequential polymerase chain reaction (PCR) and Pneumotest-Latex...
April 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28370485/19f-nmr-spectroscopic-analysis-of-the-binding-modes-in-triple-helical-pna-microrna-complexes
#15
Pasi Markus Virta, Ville Tähtinen, Lotta Granqvist, Merita Murtola, Roger Strömberg
Triplex-forming peptide nucleic acids (TFPNAs) were targeted to double helical regions of 19F-labelled RNA hairpin models (a UA-rich duplex with a hexaethylene glycol (heg) loop and a miR-215 model). In addition to the conventional UV- and CD-based detection, the binding was monitored by 19F NMR spectroscopy. Detailed information considering the stoichiometry and transition between the triple helical PNA/RNA- and (PNA)2/RNA-binding modes could be obtained. γ-(R)-hydroxymethyl-modified (thymine-1-yl- and 2-aminopyridin-3-yl-acetyl derivatives) TFPNAs were additionally synthesized, targeted to the same RNA models and the effect of the γ-(R)-hydroxymethyl group on the binding was studied...
March 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28350443/monitoring-the-disassembly-of-virus-like-particles-by-19-f-nmr
#16
Rogen L C Leung, Matthew D M Robinson, Alaa A A Ajabali, Gogulan Karunanithy, Brian Lyons, Ritu Raj, Saeed Raoufmoghaddam, Shabaz Mohammed, Timothy D W Claridge, Andrew J Baldwin, Benjamin G Davis
Virus-like particles (VLPs) are stable protein cages derived from virus coats. They have been used extensively as biomolecular platforms, e.g., nanocarriers or vaccines, but a convenient in situ technique is lacking for tracking functional status. Here, we present a simple way to monitor disassembly of (19)F-labeled VLPs derived from bacteriophage Qβ by (19)F NMR. Analysis of resonances, under a range of conditions, allowed determination not only of the particle as fully assembled but also as disassembled, as well as detection of a degraded state upon digestion by cells...
April 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28339189/polymerization-induced-self-assembly-pisa-control-over-the-morphology-of-19-f-containing-polymeric-nano-objects-for-cell-uptake-and-tracking
#17
Wei Zhao, Hang T Ta, Cheng Zhang, Andrew K Whittaker
Fluorine-containing polymeric materials are receiving increasing attention as imaging probes in fluorine-19 magnetic resonance imaging ((19)F MRI), for example to enable quantitative in vivo detection of cells. Here we describe the one-pot polymerization synthesis of (19)F-containing functional poly(oligo(ethylene glycol) methyl ether methacrylate-co-2,2,2-trifluoroethyl acrylate-b-poly(styrene-co-3-vinylbenzaldehyde) (poly(OEGA-co-TFEA)-b-poly(St-co-VBA)) copolymers as a new class of fluorinated MRI agent...
March 30, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28324771/synthesis-and-conformational-analysis-of-a-simplified-inositol-model-of-the-streptococcus-pneumoniae-19f-capsular-polysaccharide-repeating-unit
#18
Giorgio Catelani, Felicia D'Andrea, Lorenzo Guazzelli, Alessio Griselli, Nicola Testi, Maria Assunta Chiacchio, Laura Legnani, Lucio Toma
Carbohydrate mimics have been studied for a long time as useful sugar substitutes, both in the investigation of biological events and in the treatment of sugar-related diseases. Here we report further evaluation of the capabilities of inositols as carbohydrate substitutes. The conformational features of an inositol-model of a simplified repeating unit corresponding to the capsular polysaccharide of Streptococcus pneumoniae 19F has been evaluated by computational analysis, and compared to the native repeating unit...
March 14, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28318766/bacille-calmette-gu%C3%A3-rin-bcg-vaccination-at-birth-and-antibody-responses-to-childhood-vaccines-a-randomised-clinical-trial
#19
Thomas Nørrelykke Nissen, Nina Marie Birk, Gaby Smits, Dorthe Lisbeth Jeppesen, Lone Graff Stensballe, Mihai G Netea, Fiona van der Klis, Christine Stabell Benn, Ole Pryds
INTRODUCTION: BCG vaccination has been associated with beneficial non-specific effects on child health. Some immunological studies have reported heterologous effects of vaccines on antibody responses to heterologous vaccines. Within a randomised clinical trial of Bacille Calmette-Guérin (BCG) vaccination at birth, The Danish Calmette Study, we investigated the effect of BCG at birth on the antibody response to the three routine vaccines against DiTeKiPol/Act-Hib and Prevenar 13 in a subgroup of participants...
March 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28303826/prevalence-of-pneumococcal-serotypes-in-adults-%C3%A2-50-years-of-age
#20
Chand Wattal, Neeraj Goel, S P Byotra
CONTEXT: Currently, majority of studies on antibiotic resistance and serotype prevalence in Streptococcus pneumoniae are in paediatric population and there is limited epidemiologic data pertaining to elderly Indian population. AIMS: This study was undertaken to assess antibiotic resistance pattern and the coverage of the polysaccharide vaccine 23 (PPV23) in the elderly population. SETTINGS AND DESIGN: This was a prospective 2-year pneumococcal surveillance study in patients with community-acquired pneumococcal infections of ≥50 years' age group on fifty isolates of S...
January 2017: Indian Journal of Medical Microbiology
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