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herbal medicine for diabetes

Hojjat Rouhi-Boroujeni, Esfandiar Heidarian, Hamid Rouhi-Boroujeni, Fatemeh Deris, Mahmoud Rafieian-Kopaei
INTRODUCTION: Hyperlipidemia, obesity, hypertension, and diabetes are the most important risk factors for cardiovascular diseases. The aim of this systematic review article is to introduce the medicinal plants that exert significant clinical effects on hypertension, hyperlipidemia, obesity, and diabetes. METHODS: In this review article, the international research databases including MEDLINE, Google scholar, EBSCO, Academic Search, Web of Science, SciVerse, Scopus (SCOPUS), EBSCO, Academic Search, Cochrane, Central Register of Controlled Trials (CENTRAL) and a Chinese database (China Network Knowledge Infrastructure [CNKI]) were searched using the key words hyperlipidemia, hypertension, diabetes, herbal, obesity, and phytomedicine, matched by MESH, from their respective inceptions up to March, 2016...
October 21, 2016: Current Pharmaceutical Design
So Hyun Ahn, In Ae Chang, Ki-Joong Kim, Chul-Jung Kim, Uk Namgung, Chung-Sik Cho
BACKGROUND: Bogijetong decoction (BGJTD) is a herbal drug formulation used in the traditional Asian medicine to treat neuropathic insults associated with diabetes and anticancer therapy. To understand the biological basis of BGJTD on protective effects against neuropathy, we investigated physiological and biochemical responses of the sciatic nerves deranged by taxol injection or crush injury in the rats. METHODS: Dissociated Schwann cells and neurons were prepared from the sciatic nerve and dorsal root ganglia (DRG) respectively and were treated with taxol and BGJTD...
October 22, 2016: BMC Complementary and Alternative Medicine
Taiye Remi Fasola, Blessing Ukwenya, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Temitayo Olabisi Ajibade
BACKGROUND: Croton lobatus contains a high amount of antioxidant phytochemicals that probably account for its wide use as food and medicine in the traditional communities of West Africa. METHODS: The study evaluated the modulatory role of methanol extract of Croton lobatus leaf on alloxan-induced diabetes and associated cardiovascular complications. Male rats were randomly selected and assigned to one of six groups (A to F) of eight animals each: A (distilled water); B (corn oil); C (Alloxan); D (Alloxan + 100 mg kg-1 Croton lobatus); E: (Alloxan + 200 mg kg-1 C...
September 2016: Journal of Intercultural Ethnopharmacology
Ghulam Dastagir, Muhammad Afzal Rizvi
Medicinal plants are being used for treating various diseases. According to World Health Organization 80% of the world population depends on indigenous medicinal plant remedies. Herbal medicine employs fruits, vegetables, as dry materials or their extracts for the treatment of different diseases and health maintenance. Glycyrrhiza glabra (Liquorice) has been used in Europe since prehistoric times. It is well documented in written form starting with the ancient Greeks. Glycyrrhizin is the major active constituent obtained from liquorice roots, one of the most widely used in herbal preparations for the treatment of liver complaints...
September 2016: Pakistan Journal of Pharmaceutical Sciences
Miriam E Mossoba, Thomas J Flynn, Sanah Vohra, Paddy Wiesenfeld, Robert L Sprando
A recent surge in the use of dietary supplements, including herbal remedies, necessitates investigations into their safety profiles. "Dream herb," Calea zacatechichi, has long been used in traditional folk medicine for a variety of purposes and is currently being marketed in the US for medicinal purposes, including diabetes treatment. Despite the inherent vulnerability of the renal system to xenobiotic toxicity, there is a lack of safety studies on the nephrotoxic potential of this herb. Additionally, the high frequency of diabetes-associated kidney disease makes safety screening of C...
2016: Journal of Toxicology
Mehrab Dashtdar, Mohammad Reza Dashtdar, Babak Dashtdar, Gazala Afreen Khan, Karima Kardi
OBJECTIVES: The purpose of this study was to obtain a natural antibiotic from Phenol-rich compounds; for the dressing and the treatment of chronic wounds. METHODS: The Phenol-rich compound sweet gel was prepared by blending four natural herbal extracts, Acacia catechu (L.F.), Momia (Shilajit), Castanea sativa, and Ephedra sinica stapf, with combination of a sweet gel medium, including honey, maple saps, Phoenix dactylifera L. (date), pomegranate extract and Azadirachta indica gum as a stabilizer...
September 2016: Journal of Pharmacopuncture
Xuezhong Zhao, Fengsheng Li, Wanqing Sun, Ling Gao, Ki Soo Kim, Kyoung Tae Kim, Lu Cai, Zhiguo Zhang, Yang Zheng
Diabetic complications are the major cause of mortality for the patients with diabetes. Oxidative stress and inflammation have been recognized as important contributors for the development of many diabetic complications, such as diabetic nephropathy, hepatopathy, cardiomyopathy, and other cardiovascular diseases. Several studies have established the anti-inflammatory and oxidative roles of bioactive constituents in Magnolia bark, which has been widely used in the traditional herbal medicines in Chinese society...
2016: International Journal of Molecular Sciences
Xiao-Qin Wang, Xin-Rong Zou, Yuan Clare Zhang
Although traditional Chinese medicine (TCM) and Western medicine have evolved on distinct philosophical foundations and reasoning methods, an increasing body of scientific data has begun to reveal commonalities. Emerging scientific evidence has confirmed the validity and identified the molecular mechanisms of many ancient TCM theories. One example is the concept of "Kidneys Govern Bones." Here we discuss the molecular mechanisms supporting this theory and its potential significance in treating complications of chronic kidney disease (CKD) and diabetes mellitus...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Bing Pang, Tian-Yu Zhao, Lin-Hua Zhao, Fang Wan, Ru Ye, Qiang Zhou, Feng Tian, Xiao-Lin Tong
OBJECTIVE: This meta-analysis was performed to systematically assess the efficacy and safety of the Chinese herbal medicine Huangqi Guizhi Wuwu Decoction (HGWWD) for treating diabetic peripheral neuropathy. DATA SOURCES: Six electronic databases, including the Cochrane Library, MEDLINE database, Chinese Biomedical Database, Chinese National Knowledge Infrastructure Database, Chinese Science and Technique Journals Database, and the Wanfang Database, were searched on the internet for randomized controlled trials published up until 1 December 2015...
August 2016: Neural Regeneration Research
Ya-Lin Shi, Wen-Juan Liu, Xiao-Fang Zhang, Wei-Juan Su, Ning-Ning Chen, Shu-Hua Lu, Li-Ying Wang, Xiu-Lin Shi, Zhi-Bin Li, Shu-Yu Yang
BACKGROUND: Diabetes mellitus (DM) remains a major health problem worldwide. Several clinical trials have shown the superiority of the Traditional Chinese Medicine in delaying or reversing the development and progression of DM. This study aimed to evaluate the efficacy of Jinlida (JLD) granule, a Chinese herbal recipe, in the treatment of impaired glucose tolerance (IGT) and its effect on the prevention of DM. METHODS: Sixty-five IGT patients were randomized to receive one bag of JLD granules three times daily (JLD group, n = 34) or no drug intervention (control group, n = 31) for 12 weeks...
2016: Chinese Medical Journal
Rakhi Chakraborty, Swarnendu Roy, Vivekananda Mandal
Darjeeling and Sikkim Himalayas, a part of Eastern Himalayan Hotspot, is characterized by its richness of plant diversity. Herbal medicine has been one of the most popular and reliable healing practices among the different ethnic groups of this region for ages. However, the lack of documentation practice by the traditional healers has led to obscurity regarding the efficacy of herbal medicine among the present generation, though they have to depend on the same quite often. Meanwhile, several reviews have attempted to document the plants used for the treatment of diabetes from this region, but interestingly, very few research works can be obtained regarding the characterization of antidiabetic properties of the plants of this region...
September 2016: Journal of Integrative Medicine
Chang-Ik Choi
Diabetes mellitus is a chronic condition associated with the metabolic impairment of insulin actions, leading to the development of life-threatening complications. Although many kinds of oral antihyperglycemic agents with different therapeutic mechanisms have been marketed, their undesirable adverse effects, such as hypoglycemia, weight gain, and hepato-renal toxicity, have increased demand for the discovery of novel, safer antidiabetic drugs. Since the important roles of the sodium-glucose cotransporter 2 (SGLT2) for glucose homeostasis in the kidney were recently elucidated, pharmacological inhibition of SGLT2 has been considered a promising therapeutic target for the treatment of type 2 diabetes...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xuelan Gu, Nan Huang, Jie Gu, Manoj Kumar Joshi, Hongqiang Wang
ETHNOPHARMACOLOGICAL RELEVANCE: With the mounting pandemic of glucose metabolism dysregulation and type 2 Diabetes Mellitus (T2DM), traditional medicine such as traditional Chinese medicine (TCM) recipes has been widely adopted as a part of therapeutic approach, especially in Asian countries. AIM OF THE STUDY: A novel approach, which is adopted from cohort studies from epidemiology has been applied to explore the clinical efficacy, as well as the herbal component selection of a variety of TCM formulations against T2DM...
November 4, 2016: Journal of Ethnopharmacology
Abhijit A Ghadge, Aniket A Kuvalekar
AIM: As diabetes mellitus is multi-factorial disease, use of several oral hypoglycemic agents (OHAs) is the main stay of pharmacological treatment. The treatment has become more challenging and controversial as OHAs are heterogeneous in their mode of action that causes unwanted side effects. Complementary approaches such as use of medicinal plants and dietary polyunsaturated fatty acids (PUFA) with hypoglycemic and hypolipidemic activities are therefore imperative. A vast literature has independently documented the effects of OHAs, medicinal plants and PUFA for management of diabetes...
August 22, 2016: Diabetes & Metabolic Syndrome
Udoamaka Ezuruike, Jose M Prieto
It is becoming increasingly evident that patients with diabetes do not rely only on prescription drugs for their disease management. The use of herbal medicines is one of the self-management practices adopted by these patients, often without the knowledge of their healthcare practitioners. This study assessed the potential for pharmacokinetic herb-drug interactions (HDIs) amongst Nigerian adult diabetic patients. This was done through a literature analysis of the pharmacokinetic profile of their herbal medicines and prescription drugs, based on information obtained from 112 patients with type-2 diabetes attending two secondary health care facilities in Nigeria...
2016: Frontiers in Pharmacology
Negin Mozafari, Parmis Badr
BACKGROUND: Diabetes mellitus is a complex disorder of carbohydrate metabolism. According to past studies, the word ziabites in Iranian traditional medicine (ITM) correlate with diabetes. The aim of this study was to identify the definition, therapeutics, and mechanism of diabetes from the resources of ITM in order to provide new recommendations for the treatment of diabetes. METHODS: We searched therapeutic ITM books such as Exir-e-Aazam, Tibib-e-Akbari, as well as material medical ITM books such as Makhzan-ol-Advieh and Tohfat-ol-momenin to find topics on ziabites...
May 2016: Iranian Journal of Medical Sciences
Joseph Lunyera, Daphne Wang, Venance Maro, Francis Karia, David Boyd, Justin Omolo, Uptal D Patel, John W Stanifer
BACKGROUND: Diabetes is a growing burden in sub-Saharan Africa where traditional medicines (TMs) remain a primary form of healthcare in many settings. In Tanzania, TMs are frequently used to treat non-communicable diseases, yet little is known about TM practices for non-communicable diseases like diabetes. METHODS: Between December 2013 and June 2014, we assessed TM practices, including types, frequencies, reasons, and modes, among randomly selected community members...
2016: BMC Complementary and Alternative Medicine
Mohsen Dashtban, Hadi Sarir, Arash Omidi
BACKGROUND: The use of herbals in the treatment of diabetes mellitus is a well-established practice in traditional medicine. The medicinal plant Prosopis farcta has some antioxidant activity, which may be useful in diabetic patients. Since, there is no report on the antidiabetic effect of the P. farcta, this study evaluated antidiabetic activity of P. farcta bean extract (PFE) in streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: Hyperglycemia was induced in male albino Wistar rats by intraperitoneal injection of STZ (55 mg/kg body weight [BW]), after which, the animals were randomly allocated into six experimental groups as follows: Group 1: Normal rats (received normal saline), Groups 2 and 3: Normal rats received PFE; (50 and 75 mg/kg BW), Group 4: Diabetic control rats, Group 5: Diabetic rats received PFE (50 mg/kg BW), Group 6: Diabetic rats received PFE (75 mg/kg BW)...
2016: Advanced Biomedical Research
Xiaopei Cui, Hua Feng, Xia Xu, Haijun Li, Hongyu Zhang
Aim. To investigate the effect of Tongxinluo (Txl), a Chinese herbal compound, on diabetic peripheral neuropathy (DPN). Methods and Results. Diabetic rat model was established by peritoneal injection of streptozotocin (STZ). Txl ultrafine powder treatment for 16 weeks from the baseline significantly reversed the impairment of motor nerve conductive velocity (MNCV), mechanical hyperalgesia, and nerve structure. We further proved that Tongxinluo upregulates PGC-1α and its downstream factors including COX IV and SOD, which were involved in mitochondrial biogenesis...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Yu Duan, Ke Pei, Hao Cai, Sicong Tu, Zhengwei Zhang, Xinwei Cheng, Fengxian Qiao, Kailei Fan, Kunming Qin, Xiao Liu, Baochang Cai
The approach to investigate traditional Chinese medicine (TCM) is still in its infancy and has been facing enormous challenge. In this paper, a generally applicable strategy was developed for investigation on TCM systematically with an introduced interesting idea about a novel research system which called subchemome. A representative herb-pair, Astragali Radix-Fructus Corni, was successfully employed to expound this novel strategy. Firstly, subchemomes were prepared individually by applying the suitable column chromatography, each of them was detected by UV spectrophotometer or HPLC-DAD detector...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
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