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herbal medicine for diabetes

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https://www.readbyqxmd.com/read/29755562/investigation-of-%C3%AE-sitosterol-and-prangol-extracted-from-achillea-tenoifolia-along-with-whole-root-extract-on-isolated-rat-pancreatic-islets
#1
Mahban Rahimifard, Azadeh Manayi, Maryam Baeeri, Mahdi Gholami, Soodabeh Saeidnia, Mohammad Abdollahi
The genus Achillea (Asteraceae) consisting of important medicinal species, growing wildly in Iran, of which A. tenuifolia is found in Iran-o-Turan regions. Regarding the traditional use of Achillea species for treatment of diabetes and also lack of information on phyto-constituents of A. tenuifolia underground parts, in this study anti-diabetic activity of the plant have been reported. In order to find the main active components, underground parts of the plant were extracted with water and fractioned by hexane, ethyl acetate, and methanol and the separation of the main compounds were carried out via medium pressure liquid chromatography (MPLC)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29747745/the-potential-effect-of-garlic-extract-and-curcumin-nanoparticles-against-complication-accompanied-with-experimentally-induced-diabetes-in-rats
#2
Afaf D Abdel-Mageid, Mohamed E S Abou-Salem, Nancy M H A Salaam, Hoda A S El-Garhy
BACKGROUND: Modified herbal medicines implicate the combination of several therapeutic practices of native systems of medicine that may extend many earlier generations, which frequently afford valuable therapeutic benefits. PURPOSE: In this study, the role of nano-curcumin and aged garlic extract (AGE) as two modified phytomedicines on alleviating both of advanced glycation end products (AGEPs) and oxidative stress (OS) in streptozotocin (STZ) induced diabetic rats were investigated during this study...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29742480/clinical-benefits-and-pharmacology-of-scutellarin-a-comprehensive-review
#3
REVIEW
Liping Wang, Qiang Ma
Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. The current drug therapy of choice is to timely resupply the blood to the ischemic tissue; but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury...
May 6, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29727735/therapeutic-potential-of-wild-medicinal-plant-zizyphus-mauritiana-against-silica-induced-toxicity-in-wistar-albino-rats
#4
Rudra Prasad Dutta, M B Patil
ETHNOPHARMACOLOGICAL RELEVANCE: Zizyphus mauritiana (L.) of the family Rhamnaceae is a traditional herbal medicinal plant and commonly called as 'ber' (Indian jujube). It is traditionally used as food source and treats various diseases like malaria, asthma, pain killer, diarrhoea, typhoid, diabetes, and skin diseases, etc. AIM OF THE STUDY: This study aimed to evaluate the ability of extracts of barks of root and stem of Zizyphus mauritiana (ZM) to cure silica induced toxicity in Wistar albino rats...
May 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29727546/-ningmitai-capsule-for-the-treatment-of-andrological-diseases-advances-in-studies
#5
REVIEW
Hong-Cai Cai, Xue-Jun Shang
Ningmitai Capsule is a classical patent medicine prepared from multiple effective ingredients of Chinese herbal medicine, with a wide range of biological activities and a significant efficacy in the treatment of urogenital diseases. Ningmitai Capsule has been widely applied in the management of urological and andrological diseases, with a particularly ideal effect on chronic prostatitis, since its first introduction nearly 20 years ago. With no obvious adverse effect on the male reproductive system, it has also been gaining a gradual application in the treatment of such diseases as urinary tract infections, diabetes, non-gonococcal urethritis, seminal vesiculitis, acute epididymitis, overactive bladder, hematuria, and semen non-liquefaction...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29721742/herbal-medicine-use-among-type-2-diabetes-mellitus-patients-in-nigeria-understanding-the-magnitude-and-predictors-of-use
#6
Ogochukwu Ukamaka Amaeze, Roseline Iberi Aderemi-Williams, Modupeola Anuoluwapo Ayo-Vaughan, Deborah Aderoju Ogundemuren, Damilola Segun Ogunmola, Emmanuel Nwanolue Anyika
Background Patients with chronic diseases exploit complementary and alternative treatment options to manage their conditions better and improve well-being. Objective To determine the prevalence and predictors of herbal medicine use among Type 2 Diabetes patients in Lagos, Nigeria. Setting Secondary healthcare facilities in Lagos state, Nigeria. Method The study design was a cross sectional survey. A two-stage sampling approach was used to select the health facilities and patients were recruited consecutively to attain the sample size...
May 2, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29716575/terminalia-chebula-extract-prevents-scopolamine-induced-amnesia-via-cholinergic-modulation-and-anti-oxidative-effects-in-mice
#7
Min-Soo Kim, Dong Young Lee, Jun Lee, Hyun Woo Kim, Sang Hyun Sung, Jung-Soo Han, Won Kyung Jeon
BACKGROUND: Terminalia chebula Retz. (Combretaceae) is a traditional herbal medicine that is widely used in the treatment of diabetes, immunodeficiency diseases, and stomach ulcer in Asia. However, the anti-amnesic effect of T. chebula has not yet been investigated. The present study was designed to determine whether T. chebula extract (TCE) alleviates amnesia induced by scopolamine in mice. We also investigated possible mechanisms associated with cholinergic system and anti-oxidant effects...
May 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29716402/-significance-of-the-examination-of-the-metal-element-content-of-herbal-extracts-in-adjuvant-therapy
#8
Klára Szentmihályi
The consumption of herbal teas is becoming more and more popular nowadays both as luxury foods and a complementary part of medical therapy. Beside the organic agents of medicinal plants, the presence of inorganic ions is also relevant in exerting the favorable pharmacological effect. The author briefly summarizes the importance of some essential metal ions and their quantitative values in teas applied in the adjuvant therapy of diabetes and used as diuretics. The common feature of teas used in diabetes is that they contain a measurable amount of chromium and the concentration of most essential elements (such as K, Mg, Mn and Zn) is significant, which can be considered as a mineral source for some metal ions...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29695281/quantitative-study-of-medicinal-plants-used-by-the-communities-residing-in-koh-e-safaid-range-northern-pakistani-afghan-borders
#9
Wahid Hussain, Lal Badshah, Manzoor Ullah, Maroof Ali, Asghar Ali, Farrukh Hussain
BACKGROUND: The residents of remote areas mostly depend on folk knowledge of medicinal plants to cure different ailments. The present study was carried out to document and analyze traditional use regarding the medicinal plants among communities residing in Koh-e-Safaid Range northern Pakistani-Afghan border. METHODS: A purposive sampling method was used for the selection of informants, and information regarding the ethnomedicinal use of plants was collected through semi-structured interviews...
April 25, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29686718/antidiabetic-effects-of-a-chinese-herbal-medicinal-compound-sangguayin-preparation-via-pi3k-akt-signaling-pathway-in-db-db-mice
#10
Qichang Xing, Yunzhong Chen
Sangguayin (SGY), comprising four types of Chinese herbs, can be used as both food and medicine and has been clinically used to treat type 2 diabetes mellitus (T2DM) for a long time. Our previous study demonstrated the antidiabetic effect of SGY in experimental T2DM rats fed with a high-fat diet and treated with a low dose of streptozotocin. However, its mechanism of action is questionable. In this study, we refined the traditional SGY decoction and investigated its antidiabetic activity in db/db mice. We evaluated the possible molecular mechanism using skeletal muscle tissues...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29670661/effect-of-zishen-jiangtang-pill-a-chinese-herbal-product-on-rats-with-diabetic-osteoporosis
#11
Huilin Li, Shufang Chu, Hengxia Zhao, Deliang Liu, Xuemei Liu, Xi Qu, Jianpin Chen, Zengyin Li, Jinhua Li
Diabetic osteoporosis (DO) is a complication of diabetes. Zishen Jiangtang Pill (ZJP) is a Chinese herbal product which has been used in clinic to maintain blood glucose level and bone density for decades. However, the evidence about its mechanism on diabetes and osteoporosis is still unknown. The aim of this study is to investigate therapeutic effect of ZJP on DO in streptozotocin- (STZ-) induced rats. Rats were randomly assigned to 4 groups: one control group (CON), one model group (MOD), and two ZJP treatment groups (1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29669500/%C3%AE-cell-regenerative-potential-of-selected-herbal-extracts-in-alloxan-induced-diabetic-rats
#12
Anoja Priyadarshani Attanayake, Kamani Ayoma Perera Wijewardana Jayatilaka, Lakmini Kumari Boralugoda Mudduwa, Chitra Pathirana
Effective β-cell regeneration is a recognized therapeutic strategy in the treatment of type 1 diabetes mellitus. Regeneration of β-cells could be achieved via exogenous natural sources as medicinal plant extracts. Medicinal plants selected for the investigation were Spondias pinnata (Linn. f.) Kurz, Coccinia grandis (L.) Voigt and Gmelina arborea Roxb. The objective was to determine the β-cell regenerative potential of these plant extracts in alloxan induced diabetic rats. Alloxan monohydrate was used to induce diabetes (150 mg/kg, ip)...
April 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29655677/an-in-vitro-and-in-vivo-study-of-a-4-herb-formula-on-the-management-of-diet-induced-metabolic-syndrome
#13
Elaine Wat, Yanping Wang, Ken Chan, Hon Wai Law, Chi Man Koon, Kit Man Lau, Ping Chung Leung, Choly Yan, Clara Bik San Lau
BACKGROUND: Metabolic syndrome is the cluster of risk factors that leads to increased episodes of cardiovascular disease (CVD). These risk factors include but are not limited to obesity, non-alcoholic fatty liver (NAFLD), dyslipidemia, and type 2 diabetes. Since the pathogenesis of metabolic syndrome has multiple metabolic origins, there is no single treatment for it. Pharmacological approaches consist of separate drugs which target at individual risk factors which pose various side effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29623834/the-molecular-targets-of-swertiamarin-and-its-derivatives-confer-anti-diabetic-and-anti-hyperlipidemic-effects
#14
Naisargee Patel, Rajeev Kumar Tyagi, Nikunj Tandel, Neeraj Garg, Nupur Soni
The herbal plant extract of Enicostemma littorale is widely used to medicate and treat type II Diabetes. This extract in medicine has shown its value in reducing blood glucose & lipid levels, and improving the kidney functioning, lipid profile, controlling blood pressure and heart rate. The well characterized chemical components such as iridoid and secoiridoid glycosides are present in aqueous and ethanolic extracts of the plant. Swertiamarin, a secoiridoid glycoside, is identified as the lead compound that confers anti-hyperglycemic & anti-hyperlipidemic effects...
April 5, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29617347/flavonoid-8-o-glucuronides-from-the-aerial-parts-of-malva-verticillata-and-their-recovery-effects-on-alloxan-induced-pancreatic-islets-in-zebrafish
#15
Jung-Hwan Ko, Youn Hee Nam, Sun-Woo Joo, Hyoung-Geun Kim, Yeong-Geun Lee, Tong Ho Kang, Nam-In Baek
Malva verticillata (Cluster mallow), a leafy vegetable that has been popular in East Asia for a long time, has also been used in herbal teas and medicines. The aqueous fraction of the aerial parts of Malva verticillata, exhibiting a very high quantity of flavonoids compared to the EtOAc and n -BuOH fractions, exhibited significant recovery effects on pancreatic islets damaged by alloxan in zebrafish larvae. Thus, the bioactive components responsible for this anti-diabetic activity were investigated. A new flavonoid glucuronide (1) and five known flavonoids were isolated from the aqueous fraction...
April 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29593575/dai-zong-fang-a-traditional-chinese-herbal-formula-ameliorates-insulin-resistance-in-db-db-mice
#16
Lili Zhu, Xiaoyun Zhu, Guibo Sun, Xiangbao Meng, Min Wang, Hanming Cui, Jialong Wang, Yadong Zhai, Ke Yang, Yang Tang, Xiaobo Sun, Ximing Liu
Intricate health problems, such as insulin resistance (IR) and its associated diseases, call for multi-targeted therapies with few side effects. Based on traditional Chinese medicine (TCM), Dai-Zong-Fang (DZF) is an herbal formula mainly composed of Rhizoma Coptidis (Huanglian) and Fructus Aurantii Immaturus (Zhishi), of which berberine and naringin are the main constituents. Though DZF has been clinically used for treatment of IR and metabolic syndrome for decades, its mechanism in vivo remains unknown. In the present study, we observed that both DZF and metformin, the first-line drug for type 2 diabetes, ameliorated insulin resistance with significant improvement of oral glucose tolerance test (OGTT) and homeostasis model assessment of IR (HOMA-IR) level in diabetic C57BL/Ksj-Lepr db -/- ( db/db ) mice...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29590156/factors-influencing-long-term-medication-non-adherence-among-diabetes-and-hypertensive-patients-in-ghana-a-qualitative-investigation
#17
Roger A Atinga, Lily Yarney, Narissa Minta Gavu
BACKGROUND: Evidence remains limited on why diabetes and hypertensive patients admitted to long-term drug therapy miss doses or discontinue medication taking. We examined this phenomenon from the perspective of diabetes and hypertension patients at a Ghanaian teaching hospital. METHODS: Between July and December 2015, we conducted a qualitative study targeting caregivers and their patients with chronic diabetes and hypertensive on re-admission at the Korle Bu Teaching Hospital due to non-adherence to prescribed medication...
2018: PloS One
https://www.readbyqxmd.com/read/29587863/chinese-herbal-medicine-shenzhuo-formula-treatment-in-patients-with-macroalbuminuria-secondary-to-diabetic-kidney-disease-study-protocol-for-a-randomized-controlled-trial
#18
Xue-Min Zhao, Ying Zhang, Xin-Hui He, Hong-Dong Chen, Zhu-Feng Wang, Jing Guo, Xin-Miao Wang, Ze-Zheng Gao, Ji-Ping Wang, Wei Liu, Lin-Hua Zhao, Xiao-Lin Tong
BACKGROUND: Diabetic kidney disease (DKD) is a serious complication associated with diabetes mellitus and can cause end-stage renal disease (ESRD). Traditional Chinese medicine (TCM) is widely used in China to treat DKD, and in particular microalbuminuria and macroalbuminuria. This study will address the efficacy and safety of Shenzhuo Formula (SZF), a frequently prescribed TCM, in DKD patients with macroalbuminuria. METHODS/DESIGN: This study is a 24-week, randomized, multi-center, double-blinded, double-dummy, controlled, clinical trial that will include 120 DKD patients aged 18 to 80 years old with a 24-h urinary protein (24-h UP) level of between 0...
March 27, 2018: Trials
https://www.readbyqxmd.com/read/29580854/metabolomics-based-evidence-of-the-hypoglycemic-effect-of-ge-gen-jiao-tai-wan-in-type-2-diabetic-rats-via-uhplc-qtof-ms-analysis
#19
Wenbo Wang, Linlin Zhao, Zhenyu He, Ning Wu, Qiuxia Li, Xinjian Qiu, Lu Zhou, Dongsheng Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Ge-Gen-Jiao-Tai-Wan (GGJTW) formula, derived from traditional Chinese herbal medicine, is composed of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep (Ge-Gen in Chinese), Coptis chinensis Franch (Huang-Lian), and Cinnamomum cassia (L.) J. Presl (Rou-Gui). GGJTW is used for treatment of diabetes in China, reflecting the potent hypoglycemic effect of its ingredients. However, little is known of the hypoglycemic effect of GGJTW and the underlying metabolic mechanism...
March 23, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29567217/bioactive-polyphenols-in-kink%C3%A3-liba-tea-combretum-micranthum-and-their-glucose-lowering-activities
#20
Cara Welch, Jing Zhen, Emmanuel Bassène, Ilya Raskin, James Edward Simon, Qingli Wu
Herbal tea kinkéliba prepared from the leaves of Combretum micranthum has been widely consumed in West African countries for its flavor, nutritional and medicinal properties. Under bio-guided screening, the kinkéliba leaves were chemically investigated using various chromatographic and spectrometric methods that led to the identification of thirteen different flavonoid compounds. Further biological tests illustrated that the identified compounds may have synergistic effects to decrease the expression of phosphoenolpyruvate carboxykinase (PEPCK) mRNA and glucose production in an H4IIE hepatoma cell line, indicating its potential use for insulin-resistant diabetes treatment...
April 2018: Journal of Food and Drug Analysis
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