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Breast biopsy

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https://www.readbyqxmd.com/read/29793212/should-we-excise-are-there-any-clinical-or-histologic-features-that-predict-upgrade-in-papillomas-incidental-or-non-incidental
#1
Michael Zaleski, Yun An Chen, Alison L Chetlen, Julie Mack, Liyan Xu, Daleela G Dodge, Dipti M Karamchandani
The clinical decision to excise intraductal papilloma (IDP) without atypia diagnosed on biopsy remains controversial. We sought to establish clinical and histologic predictors (if any) which may predict upgrade in IDP. 296 biopsies (in 278 women) with histologic diagnosis of IDP without atypia were retrospectively identified and placed into Incidental (no corresponding imaging correlate), or Non-incidental (positive imaging correlate) groups. 253/296 (85.5%) cases were non-incidental, and 43/296 (14.5%) were incidental...
May 11, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29792741/mesenchymal-lesions-of-the-breast-what-radiologists-need-to-know
#2
Debra S Whorms, Michael D C Fishman, Priscilla J Slanetz
OBJECTIVE: Mesenchymal breast tumors originate from the various components of mammary stroma. The aim of this review is to discuss the clinical presentation, imaging appearance, and management of mesenchymal breast lesions. CONCLUSION: Although many mesenchymal tumors exhibit characteristic findings on imaging, others show nonspecific characteristics and require tissue biopsy for diagnosis. An awareness of the clinical and imaging presentation is essential in guiding the differential diagnosis and patient management...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29790178/comparison-of-sentinel-lymph-node-biopsy-guided-by-blue-dye-with-or-without-indocyanine-green-in-early-breast-cancer
#3
Songjie Shen, Qianqian Xu, Yidong Zhou, Feng Mao, Jinghong Guan, Qiang Sun
BACKGROUND: There were limited data available for a head-to-head comparison of the identification rate and survival between the combined method of indocyanine green fluorescence and blue dye versus the traditional blue dye alone method for sentinel lymph node (SLN) biopsy. METHODS: From January 2013 to December 2015, 523 eligible breast cancer patients were included in this nonrandomized prospective analysis. The identification rates, the number of SLNs identified, and the disease-free survival (DFS) between the two mapping methods were compared...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29789777/a-normalized-shear-deformation-indicator-for-ultrasound-strain-elastography-in-breast-tissues-an-in-vivo-feasibility-study
#4
Jingfeng Jiang, Bo Peng
The shear deformation under loads contains useful information for distinguishing benign breast lesions from malignant ones. In this study, we proposed a normalized shear deformation indicator (NSDI) that was derived from the concept of principal strains. Since the NSDI requires both high-quality axial and lateral (parallel and perpendicular to the beam, resp.) displacement estimates, a strategy combining high-quality speckle tracking with signal "denoising" was employed. Both techniques were previously published by our group...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789758/advantages-of-intraoperative-implant-for-interstitial-brachytherapy-for-accelerated-partial-breast-irradiation-either-frail-patients-with-early-stage-disease-or-in-locally-recurrent-breast-cancer
#5
Salvatore Cozzi, Maria Laplana, Dina Najjari, Andrea Slocker, Xavier Encinas, Joan Pera, Ferran Guedea, Cristina Gutierrez
Purpose: To describe the intraoperative multicatheter implantation technique for accelerated partial breast irradiation (APBI) delivered with high-dose-rate brachytherapy (HDR-BT). Secondarily, to evaluate outcomes and toxicity in a series of 83 patients treated with this technique at our institution. Material and methods: Retrospective analysis of a series of patients treated with HDR-BT APBI after intraoperative multicatheter interstitial implant between November 2006 and June 2017 at our institution...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789520/t1-weighted-dynamic-contrast-enhanced-magnetic-resonance-imaging-dce-mri-to-distinguish-between-concurrent-cholesterol-granuloma-and-invasive-ductal-carcinoma-of-the-breast-a-case-report
#6
Cheng-Chuan Hu, Tsun-Hou Chang, Hsian-He Hsu, Yi-Jen Pen, Jyh-Cherng Yu
BACKGROUND Cholesterol granuloma is a benign condition that can be misdiagnosed as breast cancer on mammographic and ultrasound imaging. A case of concomitant cholesterol granuloma with invasive ductal carcinoma of the left breast was imaged with ultrasound elastography and magnetic resonance imaging (MRI) methods, including T1-weighted dynamic contrast-enhanced MRI (DCE-MRI), before biopsy and histopathology. CASE REPORT A 52-year-old woman, with a previous history of intraduct papillomas in both breasts, underwent six-monthly follow-up breast imaging...
May 23, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29789230/impact-of-second-opinion-interpretation-of-breast-imaging-studies-in-patients-not-currently-diagnosed-with-breast-cancer
#7
Lauren Q Chang Sen, Ray C Mayo, Michele D Lesslie, Wei T Yang, Jessica W T Leung
PURPOSE: To study the impact of second-opinion interpretation of breast imaging studies submitted from outside facilities to a tertiary cancer center. MATERIALS AND METHODS: A retrospective database review was conducted of second-opinion interpretations rendered at our institution from January 1, 2010, to June 30, 2014, on studies from patients who did not have a concurrent breast cancer diagnosis. A total of 2,253 patients were included. RESULTS: In 800 of 2,253 patients (35...
May 19, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29788732/the-current-application-of-acosog-z0011-trial-results-is-further-implementation-of-sentinel-lymph-node-intra-operative-histopathological-examination-mandatory-in-breast-cancer-patients-a-single-centre-analysis
#8
T Nowikiewicz, W Zegarski, K Pagacz, M Nowacki, A Morawiec-Sztandera, I Glowacka-Mrotek, M Sowa, M Biedka, A Kolacinska
The main objective of the ACOSOG Z0011 trial was to determine the impact of abandoning complete axillary lymph node dissection (ALND) on survival of breast cancer patients with sentinel node lymph (SLN) metastasis in whom breast conserving therapy (BCT) had been performed. The aim of our study was to assess the clinical value of intra-operative histopathological examination of SLN. Our study comprised 1284 invasive breast cancer patients in whom sentinel lymph node biopsy (SLNB) was carried out. SLN intra-operative histopathological assessment was routinely performed in patients treated within the first period (07...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788010/metaplastic-breast-cancer-masquerading-as-liposarcoma-of-the-breast-a-case-report-following-oncoplastic-treatment
#9
Maiar Elghobashy, Naren Basu, Robert Warner, John Dickson, Abeer M Shaaban
Mammary liposarcoma is among the rarest of breast tumours. Here we report the presentation, macroscopic, microscopic, and immunohistochemical features of an extremely rare case of metaplastic carcinoma with extensive pleomorphic liposarcomatous differentiation. A 47-year-old woman presented with bilateral grade III breast ptosis and a 3 × 4 cm mass in the lower outer quadrant of the left breast. Mammography and ultrasound confirmed a well-defined mass. A core biopsy performed was diagnosed as pleomorphic liposarcoma...
May 22, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29786775/stormram-4-an-mr-safe-robotic-system-for-breast-biopsy
#10
Vincent Groenhuis, Françoise J Siepel, Jeroen Veltman, Jordy K van Zandwijk, Stefano Stramigioli
Suspicious lesions in the breast that are only visible on magnetic resonance imaging (MRI) need to be biopsied under MR guidance with high accuracy and efficiency for accurate diagnosis. The aim of this study is to present a novel robotic system, the Stormram 4, and to perform preclinical tests in an MRI environment. Excluding racks and needle, its dimensions are 72 × 51 × 40 mm. The Stormram 4 is driven by two linear and two curved pneumatic stepper motors. The linear motor is capable of exerting 63 N of force at a pressure of 0...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29785116/myopathy-due-to-hmgcr-antibodies-in-adult-mimicking-muscular-dystrophy-associated-with-cancer-and-statin-exposure-narrative-review-of-the-literature-case-report
#11
Alzira Alves de Siqueira Carvalho, Vinicius Gomes da Silva, Edmar Zanoteli, David Feder
Necrotizing autoimmune myopathy is characterized by predominant muscle fiber necrosis and regeneration with little or no inflammation. We describe a 58-year-old woman with previous breast cancer and statin use who complained of rapidly progressive weakness of lower limbs without pain, making walking, running and climbing stairs difficult. The creatine kinase level was 2,843 U/L, and muscle biopsy showed a dystrophic pattern. The genetic test for muscular dystrophies was negative and for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase was positive...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29783760/diagnosing-breast-cancer-with-microwave-technology-remaining-challenges-and-potential-solutions-with-machine-learning
#12
Bárbara L Oliveira, Daniela Godinho, Martin O'Halloran, Martin Glavin, Edward Jones, Raquel C Conceição
Currently, breast cancer often requires invasive biopsies for diagnosis, motivating researchers to design and develop non-invasive and automated diagnosis systems. Recent microwave breast imaging studies have shown how backscattered signals carry relevant information about the shape of a tumour, and tumour shape is often used with current imaging modalities to assess malignancy. This paper presents a comprehensive analysis of microwave breast diagnosis systems which use machine learning to learn characteristics of benign and malignant tumours...
May 19, 2018: Diagnostics
https://www.readbyqxmd.com/read/29780909/disseminated-silicone-granulomatosis-in-the-face-and-orbit
#13
Tiffany A Chen, Carmel L Mercado, Katie L Topping, Benjamin P Erickson, Kimberly P Cockerham, Andrea L Kossler
Purpose: To report a case of disseminated silicone granulomatosis presenting with ptosis, proptosis and vision loss. Observations: A 56-year-old female presented with ptosis, proptosis, and vision loss and was noted to have palpable, erythematous masses involving the orbit, face, trunk, and body. She had a history of bilateral silicone breast implants and cosmetic facial filler injections. Orbital biopsy demonstrated non-caseating granulomas with foreign-body giant cells and vacuoles containing material consistent with silicone...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780827/sentinel-lymph-node-biopsy-in-breast-cancer-patients-by-means-of-indocyanine-green-using-the-karl-storz-vitom%C3%A2-fluorescence-camera
#14
Thomas Papathemelis, Evi Jablonski, Anton Scharl, Tanja Hauzenberger, Michael Gerken, Monika Klinkhammer-Schalke, Matthias Hipp, Sophia Scharl
Currently, the use of radioisotope and blue dye for sentinel lymph node biopsy (SLNB) for axillary staging in breast cancer is common. Recently, indocyanine green (ICG) has been proposed as an alternative sentinel lymph node (SLN) tracking agent. We evaluated the clinical value of ICG as an additional tracer in combination with Technetium99m and as an alternative to Technetium99m for the identification of SLN in 104 breast cancer patients. 21 patients had at least 1 histologically tumor-positive SLN. All 21 patients were detected by ICG; in one of these 21 sentinel-positive patients, Technetium99m was unable to identify lymph node involvement...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780747/precision-medicine-in-hormone-receptor-positive-breast-cancer
#15
REVIEW
Azadeh Nasrazadani, Roby A Thomas, Steffi Oesterreich, Adrian V Lee
In recent decades, breast cancer has become largely manageable due to successes with hormone receptor targeting. Hormone receptor-positive tumors have favorable outcomes in comparison to estrogen receptor (ESR1, ER)/progesterone receptor-negative tumors given the targetable nature of these tumors, as well as their inherently less aggressive character. Nonetheless, treatment resistance is frequently encountered due to a variety of mechanisms, including ESR1 mutations and loss of ER expression. A new era of precision medicine utilizes a range of methodologies to allow real-time analysis of individual genomic signatures in metastases and liquid biopsies with the goal of finding clinically actionable targets...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29780511/through-tissue-imaging-of-a-live-breast-cancer-tumour-model-using-handheld-surface-enhanced-spatially-offset-resonance-raman-spectroscopy-sesorrs
#16
Fay Nicolson, Lauren E Jamieson, Samuel Mabbott, Konstantinos Plakas, Neil C Shand, Michael R Detty, Duncan Graham, Karen Faulds
In order to improve patient survival and reduce the amount of unnecessary and traumatic biopsies, non-invasive detection of cancerous tumours is of imperative and urgent need. Multicellular tumour spheroids (MTS) can be used as an ex vivo cancer tumour model, to model in vivo nanoparticle (NP) uptake by the enhanced permeability and retention (EPR) effect. Surface enhanced spatially offset Raman spectroscopy (SESORS) combines both surface enhanced Raman spectroscopy (SERS) and spatially offset Raman spectroscopy (SORS) to yield enhanced Raman signals at much greater sub-surface levels...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29776842/-risk-of-axillary-recurrence-after-sentinel-lymph-node-biopsy-before-neoadjuvant-chemotherapy-in-breast-cancer
#17
A Tardieu, C Mesnard, F Margueritte, J Mollard, A Lacorre, Y Aubard, E Deluche, T Gauthier
OBJECTIVES: In case of large breast cancer, neoadjuvant chemotherapy (NAC) can be performed to reduce the size of the tumor and thus perform a conservative surgery. The place of the sentinel lymph node biopsy (SLNB) in case of NAC is still debated. The main aim of this study is to assess the risk of axillary recurrence after negative SLNB before NAC. METHODS: It is a retrospective, observational and uni-centric study. We included 18 to 80-year-old patients with unilateral breast cancer requiring a NAC and with a negative SLNB before NAC...
May 15, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29774785/development-of-a-management-algorithm-for-the-diagnosis-of-cellular-fibroepithelial-lesions-from-core-needle-biopsies
#18
Jaehag Jung, Eunyoung Kang, Su Min Chae, Hyojin Kim, So Yeon Park, Bo La Yun, Sun Mi Kim, Mijung Jang, Sung-Won Kim, Eun-Kyu Kim
PURPOSE: Surgical excision is recommended for complete evaluation of cellular fibroepithelial lesions identified from core needle biopsy. The purpose of this study was to determine factors associated with phyllodes tumor among cellular fibroepithelial lesions from core biopsies and develop a scoring system to predict the risk of phyllodes tumor. METHODS: We retrospectively reviewed clinical data of 169 breast lesions that were diagnosed as cellular fibroepithelial lesions from core needle biopsy at the Seoul National University Bundang Hospital between March 2005 and January 2013...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29774321/sentinel-lymph-node-metastasis-in-invasive-lobular-carcinoma-of-the-breast
#19
Hikmet Erhan Güven, Mahmut Onur Kültüroğlu, Mehmet Ali Gülçelik, Cihangir Özaslan
Objective: Invasive lobular carcinoma (ILC) of the breast makes up 5 to 15 percent of all invasive breast cancers. It has distinctive clinical and histopathological features when compared to invasive ductal carcinoma (IDC). This study intends to describe factors influencing sentinel lymph node (SLN) positivity in patients with "pure" ILC. Materials and Methods: Data of 105 patients, who were treated at a tertiary oncology center, with lobular carcinoma of the breast that were subjected to SLN biopsy was probed retrospectively...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29774320/scoring-idiopathic-granulomatous-mastitis-an-effective-system-for-predicting-recurrence
#20
Tonguç Utku Yılmaz, Bora Gürel, Sertaç Ata Güler, Mehmet Ali Baran, Büşra Erşan, Seda Duman, Zafer Utkan
Objective: Idiopathic granulomatous mastitis is a breast disease without a definitive etiology. There are no definitive classifications, scoring systems or certitudes. The aim of this study is to define the factors related to the recurrence and design a scoring system. Material and Methods: Patients who were admitted to the general surgery department with symptoms of granulomatous mastitis were evaluated by ultrasonography and underwent antibiotic therapy. Granulomatous mastitis is diagnosed by core biopsy and treated with steroid therapy...
April 2018: European Journal of Breast Health
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