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https://www.readbyqxmd.com/read/28221346/synthesis-of-ent-be-43547a1-reveals-a-potent-hypoxia-selective-anticancer-agent-and-uncovers-the-biosynthetic-origin-of-the-apd-cld-natural-products
#1
Nikolaj L Villadsen, Kristian M Jacobsen, Ulrik B Keiding, Esben T Weibel, Bjørn Christiansen, Thomas Vosegaard, Morten Bjerring, Frank Jensen, Mogens Johannsen, Thomas Tørring, Thomas B Poulsen
Tumour hypoxia is speculated to be a key driver of therapeutic resistance and metastatic dissemination. Consequently, the discovery of new potent agents that selectively target the hypoxic cell population may reveal new and untapped antitumour mechanisms. Here we demonstrate that the BE-43547 subclass of the APD-CLD (amidopentadienoate-containing cyclolipodepsipeptides) natural products possesses highly hypoxia-selective growth-inhibitory activity against pancreatic cancer cells. To enable this discovery, we have developed the first synthesis of the BE-43547-macrocyclic scaffold in 16 steps (longest linear sequence), which also allowed access to the full panel of relative stereoisomers and ultimately to the assignment of stereochemical configuration...
March 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28220985/the-head-and-neck-cancer-patient-concern-inventory-%C3%A2-patient-concerns-prevalence-dental-concerns-impact-and-relationships-of-concerns-with-quality-of-life-measures
#2
Maria L Aguilar, Pamela Sandow, John W Werning, Lia Brenneman, Walter J Psoter
PURPOSE: The Patient Concern Inventory(©) (PCI) is a clinical tool of self-reported patient concerns to be used by the clinician to structure the patient-oncologist visit. It was developed in the United Kingdom to address the issues of quality of life (QOL) in head and neck cancer (HNC) patients. The purpose of the study reported here was to determine the prevalence of PCI(©) items, the associations between PCI(©) items and QOL, and to explore the importance of oral/dental issues in the patient's well-being...
February 21, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28218684/ent-abietanoids-isolated-from-isodon-serra
#3
Jun Wan, Hua-Yi Jiang, Jian-Wei Tang, Xing-Ren Li, Xue Du, Yan Li, Han-Dong Sun, Jian-Xin Pu
Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3α,14β)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature...
February 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28217433/visual-analogue-scales-vas-measuring-instruments-for-the-documentation-of-symptoms-and-therapy-monitoring-in-cases-of-allergic-rhinitis-in-everyday-health-care-position-paper-of-the-german-society-of-allergology-aeda-and-the-german-society-of-allergy-and-clinical
#4
Ludger Klimek, Karl-Christian Bergmann, Tilo Biedermann, Jean Bousquet, Peter Hellings, Kirsten Jung, Hans Merk, Heidi Olze, Wolfgang Schlenter, Philippe Stock, Johannes Ring, Martin Wagenmann, Wolfgang Wehrmann, Ralph Mösges, Oliver Pfaar
BACKROUND: Visual analogue scales (VAS) are psychometric measuring instruments designed to document the characteristics of disease-related symptom severity in individual patients and use this to achieve a rapid (statistically measurable and reproducible) classification of symptom severity and disease control. VAS can also be used in routine patient history taking and to monitor the course of a chronic disease such as allergic rhinitis (AR). More specifically, the VAS has been used to assess effectiveness of AR therapy in real life, both in intermittent and persistent disease...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/28215606/chemical-constituents-of-pholidota-cantonensis
#5
Bin Li, Zulfiqar Ali, Michael Chan, Juan Li, Mei Wang, Naohito Abe, Can-Rong Wu, Ikhlas A Khan, Wei Wang, Shun-Xiang Li
Two 9,10-dihydrophenanthrenes trivially named phocantol and phocantone, two diterpenoid glycosidesnamed phocantoside A and phocantoside B were isolated from the ethanol extract of the air-dried whole plant of Pholidota cantonensis Rolfe, together with seventeen known compounds. The structures of the four compounds were identified as 1-hydroxy-2,7-dimethoxy-9,10-dihydrophenanthro-[4,5-bcd]furan, 5-hydroxy-2,7-dimethoxy-9,10-dihydro-1,4-phenanthrenedione, (8R,13E)-ent-labd-13-ene-3α,8,15-triol 15-O-β-D-gluco-pyranoside and (5S,8R,9S,10R)-cis-cleroda-3,13(E)-diene-15,18-diol 15-O-β-D-glucopyranosyl-18-O-β-D-glucopyranoside by chemical and spectroscopic methods, including 1D and 2D NMR...
February 15, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28209435/contribution-of-equilibrative-nucleoside-transporter-ent-2-to-fluorouracil-transport-in-rat-placental-trophoblast-cells
#6
Akinori Takagi, Tomohiro Nishimura, Tomoya Akashi, Masatoshi Tomi, Emi Nakashima
Fluorouracil is used for treatment of breast cancer even in pregnant women, except during fetal organogenesis. The purpose of this study was to clarify the transport mechanism of fluorouracil at the rat placental barrier. Maternal-to-fetal transfer of [(3)H]fluorouracil in rats at gestational day 19.5 was saturable and much higher than that of [(14)C]sucrose. The uptake of [(3)H]fluorouracil was also saturable in rat placental trophoblast TR-TBT 18d-1 cells, which express both equilibrative nucleoside transporter (ENT) 1 and ENT2...
December 8, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28208891/outcomes-of-capsular-dissection-technique-with-use-of-bipolar-electrocautery-in-total-thyroidectomy-a-rural-tertiary-center-experience
#7
Amal T Das, S B Prakash, V Priyadarshini
INTRODUCTION: Total thyroidectomy is one of the most routinely performed head and neck surgical procedures with extremely low mortality. This procedure has been associated with two major complications such as recurrent laryngeal nerve injury and hypocalcaemia due to parathyroid insufficiency. The use of bipolar electrocautery has not been widely accepted in view of thermal damage to adjacent structures. AIM: To study the outcomes and complications of capsular dissection technique along with use of bipolar electrocautery in total thyroidectomy...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207987/fitness-to-drive-how-well-do-we-know-the-rules-survey-of-19-ent-surgeons-in-wales
#8
Darren Yap, Adam Shakir, Rhodri Costello, Simon Browning
Emergency department doctors and General Practitioners have a role in advising patients of their obligations to inform the DVLA regarding medical conditions that affect their ability to drive. Current guidelines are clear that the initial communication to the DVLA should be from the patient(1) . However, doctors should contact the DVLA directly if there are good reasons to do so(2) . Studies have shown that doctors' knowledge of medical restrictions placed on driving is poor (3,4,5,6) . Even if the need for a medical restriction is known, doctors are often not aware of the notification process...
February 16, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28205587/nickel-biopathways-in-tropical-nickel-hyperaccumulating-trees-from-sabah-malaysia
#9
Antony van der Ent, Damien L Callahan, Barry N Noller, Jolanta Mesjasz-Przybylowicz, Wojciech J Przybylowicz, Alban Barnabas, Hugh H Harris
The extraordinary level of accumulation of nickel (Ni) in hyperaccumulator plants is a consequence of specific metal sequestering and transport mechanisms, and knowledge of these processes is critical for advancing an understanding of transition element metabolic regulation in these plants. The Ni biopathways were elucidated in three plant species, Phyllanthus balgooyi, Phyllanthus securinegioides (Phyllanthaceae) and Rinorea bengalensis (Violaceae), that occur in Sabah (Malaysia) on the Island of Borneo. This study showed that Ni is mainly concentrated in the phloem in roots and stems (up to 16...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28204832/anti-proliferative-effect-of-jesridonin-on-paclitaxel-resistant-ec109-human-esophageal-carcinoma-cells
#10
Cong Wang, Liubin Guo, Saiqi Wang, Junwei Wang, Yongmei Li, Yinhui Dou, Ran Wang, Hongge Shi, Yu Ke, Hongmin Liu
Chemoresistance to anticancer drugs is a major obstacle in the efforts to develop a successful treatment strategy for esophageal squamous carcinoma (ESCC). Thus, the exploration of new drugs and treatment strategies for combating resistance are of utmost importance. In this study, we investigated the antitumor drug resistance activity of Jesridonin, a new ent-kaurene diterpenoid, and its possible mechanisms of action using the resistant cancer cell line, EC109/Taxol. MTT assay revealed that Jesridonin had similar IC50 values against EC109 paclitaxel-sensitive cells and drug-resistant EC109/Taxol cells in vitro...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28202097/independent-prescriber-physiotherapist-led-balance-clinic-the-southport-and-ormskirk-pathway
#11
L Burrows, T H Lesser, A V Kasbekar, N Roland, M Billing
OBJECTIVE: To report the introduction and impact of non-medical prescribing, initiated to improve patient pathways for those presenting with dizziness and balance disorders. METHODS: The Southport and Ormskirk physiotherapy-led vestibular clinic sees and treats all patients with dizziness and balance disorders referred to the ENT department. Letters are triaged by an audiologist, who also performs an otological examination and hearing test; this is followed by an assessment with the independent prescriber physiotherapist...
February 16, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28198680/improving-paranasal-sinus-computed-tomography-reporting-prior-to-functional-endoscopic-sinus-surgery-an-ent-uk-panel-perspective
#12
A Walker, P Surda, C Hopkins
No abstract text is available yet for this article.
March 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28194490/ranula-current-concept-of-pathophysiologic-basis-and-surgical-management-options
#13
Daniel Kokong, Augustine Iduh, Ikechukwu Chukwu, Joyce Mugu, Samuel Nuhu, Sule Augustine
BACKGROUND: There is no consensus opinion on a definitive surgical management option for ranulas to curtail recurrence, largely from the existing gap in knowledge on the pathophysiologic basis. AIM: To highlight the current scientific basis of ranula development that informed the preferred surgical approach. DESIGN: Retrospective cohort study. SETTING: Public Tertiary Academic Health Institution. METHOD: A 7-year 7-month study of ranulas surgically managed at our tertiary health institution was undertaken-June 1, 2008-December 31, 2015-from case files retrieved utilising the ICD-10 version 10 standard codes...
February 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28194477/maximizing-first-pass-complete-reperfusion-with-save
#14
Volker Maus, Daniel Behme, Christoph Kabbasch, Jan Borggrefe, Ioannis Tsogkas, Omid Nikoubashman, Martin Wiesmann, Michael Knauth, Anastasios Mpotsaris, Marios Nikos Psychogios
BACKGROUND: Endovascular techniques for treatment of large vessel occlusions (LVO) in patients with acute ischemic stroke (AIS) have advanced in recent years. We report a multicenter experience using a combined aspiration and stent retriever technique for mechanical thrombectomy (MT). METHODS: We retrospectively analyzed 32 consecutive MT patients using a novel, combined approach of Stent retriever Assisted Vacuum-locked Extraction (SAVE) by 3 operators at 3 stroke centers...
February 13, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28188418/interobserver-variability-of-the-house-brackmann-facial-nerve-grading-system-for-the-analysis-of-a-randomized-multi-center-phase-iii-trial
#15
Christian Scheller, Andreas Wienke, Marcos Tatagiba, Alireza Gharabaghi, Kristofer F Ramina, Konstanze Scheller, Julian Prell, Johannes Zenk, Oliver Ganslandt, Barbara Bischoff, Cordula Matthies, Thomas Westermaier, Gregor Antoniadis, Maria Teresa Pedro, Veit Rohde, Kajetan von Eckardstein, Thomas Kretschmer, Malte Kornhuber, Fred G Barker, Christian Strauss
BACKGROUND: Evidence of a high interobserver variability of the subjective House-Brackmann facial nerve grading system (HBGS) would justify cost- and time-consuming technological enhancements of objective classifications for facial nerve paresis. METHOD: A total of 112 patients were recruited for a randomized multi-center trial to investigate the efficacy of prophylactic nimodipine treatment in vestibular schwannoma (VS) surgery. For the present investigation both treatment groups were pooled for the assessment of facial nerve function preoperatively, in the early postoperative course and 1 year after the surgery...
February 10, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28186744/convergent-route-to-ent-kaurane-diterpenoids-total-synthesis-of-lungshengenin-d-and-1%C3%AE-6%C3%AE-diacetoxy-ent-kaura-9-11-16-dien-12-15-dione
#16
Xiangbo Zhao, Wu Li, Junjie Wang, Dawei Ma
The Hoppe's homoaldol reaction of a cyclo-hexenyl carbamate with an aldehyde followed by an unprecedented BF3·OEt2 mediated intramolecular Mukaiyama-Michael-type reaction affords the tetracyclic core structure of ent-kaurane diterpenoids. The usage of this convergent approach for assembling these natural products is demonstrated by the first asymmetric total syntheses of two highly oxidized ent-kaurane diterpenoids: Lungshengenin D and 1α,6α-diacetoxy-ent-kaura-9(11),16-dien-12,15-dione.
February 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28178329/systematic-high-resolution-assessment-of-global-hydropower-potential
#17
Olivier A C Hoes, Lourens J J Meijer, Ruud J van der Ent, Nick C van de Giesen
Population growth, increasing energy demand and the depletion of fossil fuel reserves necessitate a search for sustainable alternatives for electricity generation. Hydropower could replace a large part of the contribution of gas and oil to the present energy mix. However, previous high-resolution estimates of hydropower potential have been local, and have yet to be applied on a global scale. This study is the first to formally present a detailed evaluation of the hydropower potential of each location, based on slope and discharge of each river in the world...
2017: PloS One
https://www.readbyqxmd.com/read/28177333/high-definition-video-telescopic-rhinoplasty
#18
I Tasca, G Ceroni Compadretti, C Romano
Optical magnification has become an essential tool in rhinologic practice, especially following the popularisation of endoscopic procedures for nasal sinus surgery. We describe the use of VITOM(®) technology in rhinoplasty, which to our knowledge has not been reported in the international literature to date. This approach to rhinoplasty markedly improves visualisation of the surgical field, thereby improving the understanding of the procedures and enhancing the teaching environment. Since VITOM(®) technology works by combining the telescope with a standard endoscopic setting, video telescopic rhinoplasty may be easily and inexpensively performed in any ENT department provided with this instrumentation...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28170239/synthetic-control-of-exciton-behavior-in-colloidal-quantum-dots
#19
Chaodan Pu, Haiyan Qin, Yuan Gao, Jianhai Zhou, Peng Wang, Xiaogang Peng
Colloidal quantum dots are promising optical and optoelectronic materials for various applications, whose perfor-mance is dominated by their excited-state properties. This article illustrates synthetic control of their excited states. Description of the excited states of quantum-dot emitters can be centered around exciton. We shall discuss that, differ-ent from conventional molecular emitters, ground-state structures of quantum dots are not necessarily correlated with their excited states. Synthetic control of exciton behavior heavily relies on convenient and affordable monitoring tools...
February 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28170228/a-pair-of-residues-that-interactively-affect-diterpene-synthase-product-outcome
#20
Meirong Jia, Ke Zhou, Samuel Tufts, Samuel Schulte, Reuben J Peters
The labdane-related diterpenoids (LRDs) are an important superfamily of natural products whose structural diversity critically depends on the hydrocarbon skeletal structures generated, in large part, by class I diterpene synthases. In the plant kingdom, where the LRDs are predominantly found, the relevant class I diterpene synthases are clearly derived from the ent-kaurene synthase (KS) required in all land plants for phytohormone biosynthesis and, hence, are often termed KS-like (KSL). Previous work, initiated by the distinct function of two alleles of a KSL from rice, OsKSL5, identified a single residue switch with a profound effect on not only OsKSL5 product outcome but also that of land plant KSs more broadly, specifically, replacement of a key isoleucine with threonine, which interrupts formation of the tetracyclic ent-isokaurene at the tricyclic stage, leading to production of ent-pimaradiene instead...
February 14, 2017: ACS Chemical Biology
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