keyword
https://read.qxmd.com/read/38466881/berberine-alleviates-concanavalin-a-induced-autoimmune-hepatitis-in-mice-by-modulating-the-gut-microbiota
#21
JOURNAL ARTICLE
Hao Yang, Qingqing Liu, Haixia Liu, Xing Kang, Haixia Tian, Yongbo Kang, Lin Li, Xiaodan Yang, Peng Ren, Xiaoyu Kuang, Xiaohui Wang, Linzhi Guo, Mingwei Tong, Jieqiong Ma, Weiping Fan
BACKGROUND: Autoimmune hepatitis (AIH) is an immune-mediated liver disease of unknown etiology accompanied by intestinal dysbiosis and a damaged intestinal barrier. Berberine (BBR) is a traditional antibacterial medicine that has a variety of pharmacological properties. It has been reported that BBR alleviates AIH, but relevant mechanisms remain to be fully explored. METHODS: BBR was orally administered at doses of 100 mg⋅kg-1⋅d-1 for 7 days to mice before concanavalin A-induced AIH model establishment...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38464968/children-with-idiopathic-short-stature-have-significantly-different-gut-microbiota-than-their-normal-height-siblings-a-case-control-study
#22
JOURNAL ARTICLE
Liora Lazar, Adi Eshel, Lelyan Moadi, Michal Yackobovitch-Gavan, Meytal Bar-Maisels, Biana Shtaif, Michal Nevo, Moshe Phillip, Sondra Turjeman, Omry Koren, Galia Gat-Yablonski
OBJECTIVES: To investigate the role of gut microbiota (GM) in pathogenesis of idiopathic short stature (ISS) by comparing GM of ISS children to their normal-height siblings. METHODS: This case-control study, conducted at the Schneider Children's Medical Center's Institute for Endocrinology and Diabetes between 4/2018-11/2020, involved 30 pairs of healthy pre-pubertal siblings aged 3-10 years, each comprising one sibling with ISS and one with normal height. Outcome measures from fecal analysis of both siblings included GM composition analyzed by 16S rRNA sequencing, fecal metabolomics, and monitoring the growth of germ-free (GF) mice after fecal transplantation...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38464791/ginsenoside-rk3-modulates-gut-microbiota-and-regulates-immune-response-of-group-3-innate-lymphoid-cells-to-against-colorectal-tumorigenesis
#23
JOURNAL ARTICLE
Xue Bai, Rongzhan Fu, Yannan Liu, Jianjun Deng, Qiang Fei, Zhiguang Duan, Chenhui Zhu, Daidi Fan
The gut microbiota plays a pivotal role in the immunomodulatory and protumorigenic microenvironment of colorectal cancer (CRC). However, the effect of ginsenoside Rk3 (Rk3) on CRC and gut microbiota remains unclear. Therefore, the purpose of this study is to explore the potential effect of Rk3 on CRC from the perspective of gut microbiota and immune regulation. Our results reveal that treatment with Rk3 significantly suppresses the formation of colon tumors, repairs intestinal barrier damage, and regulates the gut microbiota imbalance caused by CRC, including enrichment of probiotics such as Akkermansia muciniphila and Barnesiella intestinihominis , and clearance of pathogenic Desulfovibrio ...
February 2024: Journal of Pharmaceutical Analysis
https://read.qxmd.com/read/38464781/gut-microbiome-based-thiamine-metabolism-contributes-to-the-protective-effect-of-one-acidic-polysaccharide-from-selaginella-uncinata-desv-spring-against-inflammatory-bowel-disease
#24
JOURNAL ARTICLE
Haochen Hui, Zhuoya Wang, Xuerong Zhao, Lina Xu, Lianhong Yin, Feifei Wang, Liping Qu, Jinyong Peng
Inflammatory bowel disease (IBD) is a serious disorder, and exploration of active compounds to treat it is necessary. An acidic polysaccharide named SUSP-4 was purified from Selaginella uncinata (Desv.) Spring, which contained galacturonic acid, galactose, xylose, arabinose, and rhamnose with the main chain structure of →4)-α-d-GalAp-(1→ and →6)-β-d-Galp-(1→ and the branched structure of →5)-α-l-Araf-(1→ . Animal experiments showed that compared with Model group, SUSP-4 significantly improved body weight status, disease activity index (DAI), colonic shortening, and histopathological damage, and elevated occludin and zonula occludens protein 1 (ZO-1) expression in mice induced by dextran sulfate sodium salt (DSS)...
February 2024: Journal of Pharmaceutical Analysis
https://read.qxmd.com/read/38461664/polystyrene-microplastics-promote-intestinal-colonization-of-aeromonas-veronii-through-inducing-intestinal-microbiota-dysbiosis
#25
JOURNAL ARTICLE
Yuqi Wang, Chao Gao, Wenfang Niu, Shuo Han, Mengyuan Qin, Zhuo Tian, Wenjing Zuo, Xiaohua Xia, Hailei Wang, Yi Li
The premise that pathogen colonized microplastics (MPs) can promote the spread of pathogens has been widely recognized, however, their role in the colonization of pathogens in a host intestine has not been fully elucidated. Here, we investigated the effect of polystyrene MPs (PS-MPs) on the colonization levels of Aeromonas veronii, a typical aquatic pathogen, in the loach (Misgurnus anguillicaudatus) intestine. Multiple types of MPs were observed to promote the intestinal colonization of A. veronii, among which PS-MPs exhibited the most significant stimulating effect (67...
March 8, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38460630/vitexin-rhamnoside-encapsulated-with-zein-pectin-nanoparticles-relieved-high-fat-diet-induced-lipid-metabolism-disorders-in-mice-by-altering-the-gut-microbiota
#26
JOURNAL ARTICLE
Xin Huang, Xiaopei Hu, Suhong Li, Tuoping Li
This study aimed to investigate the modulatory effects of Vitexin-rhamnoside (VR) and Zein-VR-pectin nanoparticles (VRN) on lipid metabolism disorders induced by high-fat diet (HFD). The ingestion of VR or VRN attenuated dyslipidemia and fat accumulation in HFD mice, and improved intestinal dysbiosis by regulating the relative abundance of dominant bacteria, alleviating chronic inflammation and hepatic injury in HFD mice. The intervention effect of VRN was significantly higher than that of VR. After fecal microbiota transplantation (FMT) treatment, the fecal microbiota of VRN-treated donor mice significantly attenuated the symptoms associated with hyperlipidemia, confirming that VRN ameliorates HFD-induced disorders of lipid metabolism by modulating the gut microbiota, especially increasing the abundance of Rombousia and Faecalibaculum...
March 7, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38459479/polyphyllin-b-inhibited-stat3-ncoa4-pathway-and-restored-gut-microbiota-to-ameliorate-lung-tissue-injury-in-cigarette-smoke-induced-mice
#27
JOURNAL ARTICLE
Qing Wang, Zhiyi He, Jinqi Zhu, Mengyun Hu, Liu Yang, Hongzhong Yang
OBJECTIVE: Smoking was a major risk factor for chronic obstructive pulmonary disease (COPD). This study plan to explore the mechanism of Polyphyllin B in lung injury induced by cigarette smoke (CSE) in COPD. METHODS: Network pharmacology and molecular docking were applied to analyze the potential binding targets for Polyphyllin B and COPD. Commercial unfiltered CSE and LPS were used to construct BEAS-2B cell injury in vitro and COPD mouse models in vivo, respectively, which were treated with Polyphyllin B or fecal microbiota transplantation (FMT)...
March 8, 2024: BMC Biotechnology
https://read.qxmd.com/read/38457115/successful-treatment-of-recurrent-clostridioides-difficile-infection-using-a-novel-drinkable-oral-formulation-of-fecal-microbiota
#28
JOURNAL ARTICLE
Michael J Sadowsky, Michael Matson, Prince P Mathai, Maradi Pho, Christopher Staley, Clayton Evert, Melissa Weldy, Alexander Khoruts
BACKGROUND: Fecal microbiota transplants can be administered orally in encapsulated form or require invasive procedures to administer liquid formulations. There is a need for an oral liquid formulation of fecal microbiota for patients who are unable to swallow capsules, especially if they require multiple, repeated administrations. AIMS: These studies were conducted to develop a protocol to manufacture an organoleptically acceptable powdered fecal microbiota formulation that can be suspended in a liquid carrier and used for fecal microbiota transplantation...
March 8, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38452932/microbial-bile-acid-metabolite-ameliorates-mycophenolate-mofetil-induced-gastrointestinal-toxicity-through-vitamin-d3-receptor
#29
JOURNAL ARTICLE
Di Zhang, Wei Lv, Yue Xu, Zijian Zhang, Song Zeng, Weixun Zhang, Lian Gong, Limei Shao, Min Zhang, Tian He, Yingying Liu, Yuxuan Wang, Ling Liu, Xiaopeng Hu
Mycophenolate mofetil (MMF) is one of the most used immunosuppressive drugs in organ transplantation, but frequent gastrointestinal (GI) side effects through unknown mechanisms limit its clinical use. Gut microbiota and its metabolites were recently reported to play a vital role in MMF-induced GI toxicity, but the specific mechanism of how they interact with the human body is still unclear. Here, we found that secondary bile acids (BAs), as bacterial metabolites, were significantly reduced by MMF administration in the gut of mice...
March 5, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38449863/protective-effects-of-fecal-microbiota-transplantation-against-ischemic-stroke-and-other-neurological-disorders-an-update
#30
REVIEW
Tousif Ahmed Hediyal, C Vichitra, Nikhilesh Anand, Mahendran Bhaskaran, Saeefh M Essa, Pravir Kumar, M Walid Qoronfleh, Mohammed Akbar, Ruchika Kaul-Ghanekar, Arehally M Mahalakshmi, Jian Yang, Byoung-Joon Song, Tanya M Monaghan, Meena Kishore Sakharkar, Saravana Babu Chidambaram
The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (GM) produce neuroactives, specifically neurotransmitters that modulates local and central neuronal brain functions. An imbalance between intestinal commensals and pathobionts leads to a disruption in the gut microbiota or dysbiosis, which affects intestinal barrier integrity and gut-immune and neuroimmune systems...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38447617/artemisia-capillaris-thunb-polysaccharide-alleviates-cholestatic-liver-injury-through-gut-microbiota-modulation-and-nrf2-signaling-pathway-activation-in-mice
#31
JOURNAL ARTICLE
Jingyi Cai, Zhenyun Zhu, Yuanyuan Li, Qi Li, Tian Tian, Qian Meng, Tianming Wang, Yueming Ma, Jiasheng Wu
ETHNOPHARMACOLOGICAL RELEVANCE: According to traditional Chinese medicine (TCM) theory, cholestasis belongs to category of jaundice. Artemisia capillaris Thunb. has been widely used for the treatment of jaundice in TCM. The polysaccharides are the one of main active components of the herb, but its effects on cholestasis remain unclear. AIM OF THE STUDY: To investigate the protective effect and mechanism of Artemisia capillaris Thunb. polysaccharide (APS) on cholestasis and liver injury...
March 4, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38446328/involvement-of-gut-microbiota-in-multiple-sclerosis-review-of-a-new-pathophysiological-hypothesis-and-potential-treatment-target
#32
REVIEW
Piotr Olejnik, Kasper Buczma, Agnieszka Cudnoch-Jędrzejewska, Kaja Kasarełło
Multiple sclerosis (MS) is a chronic inflammatory disease that leads to demyelination and damage to the central nervous system. It is well known, the significance of the involvement and influence of the immune system in the development and course of MS. Nowadays, more and more studies are demonstrating that an important factor that affects the action of the immune system is the gut microbiota. Changes in the composition and interrelationships in the gut microbiota have a significant impact on the course of MS...
March 6, 2024: Immunologic Research
https://read.qxmd.com/read/38446309/factors-underlying-the-difference-in-response-to-fecal-microbiota-transplantation-between-ibs-patients-with-severe-and-moderate-symptoms
#33
JOURNAL ARTICLE
Magdy El-Salhy, Jan Gunnar Hatlebakk
BACKGROUND: Previous studies showed that patients with Severe IBS respond better to fecal microbiota transplantation (FMT) than do those with Moderate IBS. AIMS: The present study aimed to determine the effects of the transplant dose, route of administering it and repeating FMT on this difference. METHODS: This study included 186 patients with IBS randomized 1:1:1 into groups with a 90-g transplant administered once to the colon (LI), once to the duodenum (SI), or twice to the distal duodenum twice (repeated SI)...
March 6, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38444807/effects-of-fecal-microbiota-transplantation-on-metabolic-health-of-dba-mice
#34
JOURNAL ARTICLE
Wenxin Ye, Jinghui Fan, Wenzi Wu, Zhuo Chen, Qixin Huang, Lichun Qian
INTRODUCTION: Numerous studies have demonstrated that C57BL/6 mice exhibit superior growth rates and overall growth performance compared to DBA mice. To investigate whether this discrepancy in growth performance is linked to the composition of gut microorganisms, we conducted fecal microbiome transplantation (FMT) experiments. METHODS: Specifically, we transplanted fecal fluids from adult C57BL/6 mice, high-fat C57BL/6 mice, and Wistar rats into weaned DBA mice (0...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38439546/a-metagenomic-prospective-cohort-study-on-gut-microbiome-composition-and-clinical-infection-in-small-bowel-transplantation
#35
JOURNAL ARTICLE
Archana Madhav, Rachel Bousfield, Joana Pereira-Dias, Claire Cormie, Sally Forrest, Jacqueline Keane, Leanne Kermack, Ellen Higginson, Gordon Dougan, Harry Spiers, Dunecan Massey, Lisa Sharkey, Charlotte Rutter, Jeremy Woodward, Neil Russell, Irum Amin, Andrew Butler, Kayleigh Atkinson, Tom Dymond, Josefin Bartholdson Scott, Stephen Baker, Effrossyni Gkrania-Klotsas
Two-thirds of small-bowel transplantation (SBT) recipients develop bacteremia, with the majority of infections occurring within 3 months post-transplant. Sepsis-related mortality occurs in 31% of patients and is commonly caused by bacteria of gut origin, which are thought to translocate across the implanted organ. Serial post-transplant surveillance endoscopies provide an opportunity to study whether the composition of the ileal and colonic microbiota can predict the emergence as well as the pathogen of subsequent clinical infections in the SBT patient population...
2024: Gut Microbes
https://read.qxmd.com/read/38436067/gut-microbiota-palmitoleic-acid-interleukin-5-axis-orchestrates-benzene-induced-hematopoietic-toxicity
#36
JOURNAL ARTICLE
Lei Zhang, Ziyan Liu, Wei Zhang, Jingyu Wang, Huiwen Kang, Jiaru Jing, Lin Han, Ai Gao
Due to the annual increase in its production and consumption in occupational environments, the adverse blood outcomes caused by benzene are of concern. However, the mechanism of benzene-induced hematopoietic damage remains elusive. Here, we report that benzene exposure causes hematopoietic damage in a dose-dependent manner and is associated with disturbances in gut microbiota-long chain fatty acids (LCFAs)-inflammation axis. C57BL/6J mice exposed to benzene for 45 days were found to have a significant reduction in whole blood cells and the suppression of hematopoiesis, an increase in Bacteroides acidifaciens and a decrease in Lactobacillus murinus ...
2024: Gut Microbes
https://read.qxmd.com/read/38435309/unraveling-the-microbial-puzzle-exploring-the-intricate-role-of-gut-microbiota-in-endometriosis-pathogenesis
#37
REVIEW
Fan Tang, Mengqi Deng, Chunyu Xu, Ruiye Yang, Xuechao Ji, Menglin Hao, Yixiao Wang, Ming Tian, Yuning Geng, Jinwei Miao
Endometriosis (EMs) is a prevalent gynecological disorder characterized by the growth of uterine tissue outside the uterine cavity, causing debilitating symptoms and infertility. Despite its prevalence, the exact mechanisms behind EMs development remain incompletely understood. This article presents a comprehensive overview of the relationship between gut microbiota imbalance and EMs pathogenesis. Recent research indicates that gut microbiota plays a pivotal role in various aspects of EMs, including immune regulation, generation of inflammatory factors, angiopoietin release, hormonal regulation, and endotoxin production...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38430889/targeted-modulation-of-gut-and-intra-tumor-microbiota-to-improve-the-quality-of-immune-checkpoint-inhibitor-responses
#38
REVIEW
WeiZhou Wang, JunYing Fan, Chi Zhang, Yuan Huang, Yue Chen, ShaoZhi Fu, JingBo Wu
Immune checkpoint inhibitor (ICI) therapies, such as those blocking the interaction of PD-1 with its ligands, can restore the immune-killing function of T cells. However, ICI therapy is clinically beneficial in only a small number of patients, and it is difficult to predict post-treatment outcomes, thereby limiting its widespread clinical use. Research suggests that gut microbiota can regulate the host immune system and affect cancer progression and treatment. Moreover, the effectiveness of immunotherapy is related to the composition of the patient's gut microbiota; different gut microbial strains can either activate or inhibit the immune response...
February 29, 2024: Microbiological Research
https://read.qxmd.com/read/38428658/gegen-qinlian-decoction-ameliorates-tnbs-induced-ulcerative-colitis-by-regulating-th2-th1-and-tregs-th17%C3%A2-cells-balance-inhibiting-nlrp3-inflammasome-activation-and-reshaping-gut-microbiota
#39
JOURNAL ARTICLE
Yingnan Hu, Jingyi Tang, Yongfeng Xie, Wenjun Xu, Weihan Zhu, Linying Xia, Jintao Fang, Dian Yu, Jingjing Liu, Zhipeng Zheng, Qiujing Zhou, Qiyang Shou, Wei Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Chinese herbal medicine Gegen Qinlian Decoction (GQD) has been clinically shown to be an effective treatment of ulcerative colitis (UC) in China. However, the underlying mechanism of GQD's anti-ulcerative colitis properties and its effect on gut microbiota still deserve further exploration. AIM OF THE STUDY: This study observed the regulatory effects of GQD on Th2/Th1 and Tregs/Th17 cells balance, the NOD-like receptor family pyrin domain containing 3 (NLRP3) infammasome and gut microbiota in TNBS-induced UC in BALB/c mice...
February 28, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38428648/lipopolysaccharide-producing-veillonella-infantium-and-escherichia-fergusonii-cause-vagus-nerve-mediated-cognitive-impairment-in-mice
#40
JOURNAL ARTICLE
Xiaoyang Ma, Jeon-Kyung Kim, Yoon-Jung Shin, Hee-Seo Park, Dong-Yun Lee, Sung-Vin Yim, Dong-Hyun Kim
Gut microbiota communicates bidirectionally with the brain through the nervous, immune, and endocrine systems of the gut. In our preliminary study, the fecal microbiota of volunteers with mild cognitive impairment (Fmci) exhibited a higher abundance of Escherichia fergusonii (NK2001), Veillonella infantium (NK2002), and Enterococcus faecium (NK2003) populations compared with those of healthy volunteers. Therefore, we examined the effects of Fmci, NK2001 (gram-negative), NK2002 (gram-negative-like), and NK2003 (gram-positive) on cognitive impairment-like behavior, neuroinflammation, and colitis in mice with or without antibiotics...
February 28, 2024: Brain, Behavior, and Immunity
keyword
keyword
20139
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.