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Fecal microbiota transplant

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https://www.readbyqxmd.com/read/27922565/a-perspective-on-brain-gut-communication-the-american-gastroenterology-association-and-american-psychosomatic-society-joint-symposium-on-brain-gut-interactions-and-the-intestinal-microenvironment
#1
Olga C Aroniadis, Douglas A Drossman, Magnus Simren
BACKGROUND: Alterations in brain-gut communication and the intestinal microenvironment have been implicated in a variety of medical and neuropsychiatric diseases. Three central areas require basic and clinical research: (1) how the intestinal microenvironment interacts with the host immune system, central nervous system and enteric nervous system; (2) the role of the intestinal microenvironment in the pathogenesis of medical and neuropsychiatric disease; (3) the effects of diet, prebiotics, probiotics and fecal microbiota transplantation on the intestinal microenvironment and the treatment of disease...
December 2, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27912759/intestinal-dysbiosis-and-allogeneic-hematopoietic-progenitor-cell-transplantation
#2
REVIEW
Vikram M Raghunathan, Iris Sheng, Seah H Lim
The intestinal microbiota is a diverse and dynamic ecosystem that is increasingly understood to play a vital role in human health. Hematopoietic stem cell transplant recipients undergo prolonged exposure to antimicrobials, chemotherapeutic agents, and immunosuppressants, resulting in profound shifts in the gut microbiome. A growing body of research has revealed the ways in which these microbiologic shifts shape immune modulation, affecting susceptibility to infections and graft-versus-host disease, the two major post-transplant complications in this population...
December 3, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27893543/changes-in-intestinal-microbiota-following-combination-therapy-with-fecal-microbial-transplantation-and-antibiotics-for-ulcerative-colitis
#3
Dai Ishikawa, Takashi Sasaki, Taro Osada, Kyoko Kuwahara-Arai, Keiichi Haga, Tomoyoshi Shibuya, Keiichi Hiramatsu, Sumio Watanabe
BACKGROUND: Fecal microbiota transplantation (FMT) is a potential therapeutic approach to restore normal intestinal microbiota in patients with ulcerative colitis (UC), which is associated with dysbiosis; however, treatment efficacy remains unclear. Hence, we studied the impact of antibiotic pretreatment with amoxicillin, fosfomycin, and metronidazole (AFM therapy) and FMT versus AFM alone. METHODS: AFM therapy was administered to patients for 2 weeks until 2 days before FMT...
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27890791/fecal-microbiota-manipulation-prevents-dysbiosis-and-alcohol-induced-liver-injury-in-mice
#4
Gladys Ferrere, Laura Wrzosek, Frédéric Cailleux, Williams Turpin, Virginie Puchois, Madeleine Spatz, Dragos Ciocan, Dominique Rainteau, Lydie Humbert, Cindy Hugot, Françoise Gaudin, Marie-Louise Noordine, Véronique Robert, Dominique Berrebi, Muriel Thomas, Sylvie Naveau, Gabriel Perlemuter, Anne-Marie Cassard
BACKGROUND AND AIMS: Alcoholic liver disease (ALD) is a leading cause of liver failure and mortality. In humans, severe alcoholic hepatitis is associated with key changes of intestinal microbiota (IM), which influences individual sensitivity to develop advanced ALD. We used the different susceptibility to ALD observed in two distinct animal facilities to test the efficiency of two complementary strategies (fecal microbiota transplantation and prebiotic treatment) to reverse dysbiosis and prevent ALD...
November 24, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27879485/patients-views-on-fecal-microbiota-transplantation-an-acceptable-therapeutic-option-in-inflammatory-bowel-disease
#5
Jonas Zeitz, Marina Bissig, Christiane Barthel, Luc Biedermann, Sylvie Scharl, Daniel Pohl, Pascal Frei, Stephan R Vavricka, Michael Fried, Gerhard Rogler, Michael Scharl
BACKGROUND: Fecal microbiota transplantation (FMT) represents a new therapeutic option that has been studied in two randomized-controlled trials in ulcerative colitis patients. Our study aimed to identify patients' views on the use of this novel therapeutic approach. METHODS: Using an anonymous questionnaire, we obtained data from 574 inflammatory bowel disease (IBD) patients on their knowledge and willingness to undergo FMT. RESULTS: A large proportion of IBD patients (53...
November 22, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27876339/diagnosis-and-treatment-of-clostridium-difficile-c-diff-colitis-review-of-the-literature-and-a-perspective-in-gynecologic-oncology
#6
REVIEW
Kristin N Taylor, Michael T McHale, Cheryl C Saenz, Steven C Plaxe
Clostridium difficile infection (CDI) is a major cause of nosocomial diarrhea with the potential for significant morbidity and mortality. Colonization in a susceptible individual, with risk factors such as prior antibiotic use, advanced age, or medical comorbidities, may result in symptomatic infection. Although patients with a gynecologic malignancy may be at a higher risk of developing CDI due to an increased likelihood of having one or more risk factors, data do not consistently support the idea that chemotherapy or cancer itself are independently associated with CDI...
November 19, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27866880/efficacy-of-sterile-fecal-filtrate-transfer-for-treating-patients-with-clostridium-difficile-infection
#7
Stephan J Ott, Georg H Waetzig, Ateequr Rehman, Jacqueline Moltzau-Anderson, Richa Bharti, Juris A Grasis, Liam Cassidy, Andreas Tholey, Helmut Fickenscher, Dirk Seegert, Philip Rosenstiel, Stefan Schreiber
BACKGROUND & AIMS: Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We investigated whether sterile fecal filtrates (containing bacterial debris, proteins, antimicrobial compounds, metabolic products and oligonucleotides/DNA), rather than intact microorganisms, are effective in patients with CDI...
November 17, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27861129/an-evaluation-of-the-therapeutic-potential-of-fecal-microbiota-transplantation-to-treat-infectious-and-metabolic-diseases
#8
Albert K Groen, Max Nieuwdorp
No abstract text is available yet for this article.
November 9, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27856521/gleaning-insights-from-fecal-microbiota-transplantation-and-probiotic-studies-for-the-rational-design-of-combination-microbial-therapies
#9
REVIEW
Lauren E Hudson, Sarah E Anderson, Anita H Corbett, Tracey J Lamb
Beneficial microorganisms hold promise for the treatment of numerous gastrointestinal diseases. The transfer of whole microbiota via fecal transplantation has already been shown to ameliorate the severity of diseases such as Clostridium difficile infection, inflammatory bowel disease, and others. However, the exact mechanisms of fecal microbiota transplant efficacy and the particular strains conferring this benefit are still unclear. Rationally designed combinations of microbial preparations may enable more efficient and effective treatment approaches tailored to particular diseases...
January 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/27850226/586-fecal-microbiota-transplantation-in-severe-initial-clostridium-difficile-infection-a-meta-analysis
#10
Sandhya Samavedam, Sumedh Hoskote
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27832684/fecal-microbiota-transplantation-and-the-brain-microbiota-in-neurological-diseases
#11
Marco Ruggiero
No abstract text is available yet for this article.
November 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/27822485/fecal-microbiota-transplantation-by-freeze-dried-oral-capsules-for-recurrent-clostridium-difficile-infection
#12
Michelle T Hecker, Mark E Obrenovich, Jennifer L Cadnum, Annette L Jencson, Alok K Jain, Edith Ho, Curtis J Donskey
No abstract text is available yet for this article.
April 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27816755/healthy-donor-fecal-microbiota-transplantation-in-steroid-ineligible-severe-alcoholic-hepatitis-a-pilot-study
#13
Cyriac Abby Philips, Apurva Pande, S Murali Shasthry, Kapil Dev Jamwal, Vikas Khillan, Shivendra Singh Chandel, Guresh Kumar, Manoj K Sharma, Rakhi Maiwall, Ankur Jindal, Ashok Choudhary, Md Shabbir Hussain, Shvetank Sharma, Shiv K Sarin
No abstract text is available yet for this article.
November 2, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27809778/pectin-enhances-the-effect-of-fecal-microbiota-transplantation-in-ulcerative-colitis-by-delaying-the-loss-of-diversity-of-gut-flora
#14
Yao Wei, Jianfeng Gong, Weiming Zhu, Hongliang Tian, Chao Ding, Lili Gu, Ning Li, Jieshou Li
BACKGROUND: Fecal microbiota transplantation (FMT) induces remission in ulcerative colitis (UC). However, the treatment effect of FMT diminishes over time. Maintaining the diversity of the gut flora for long periods may improve the effects of FMT in UC. Pectin, which can be fermented by gut microbiota into short-chain fatty acids, is postulated to shape the composition and maintain the balance of gut microbiota following transplantation. This study investigated whether pectin could enhance the effects of FMT in UC patients...
November 3, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27800166/an-assessment-of-the-future-impact-of-alternative-technologies-on-antibiotics-markets
#15
Ejike Nwokoro, Ross Leach, Christine Årdal, Enrico Baraldi, Kellie Ryan, Jens Plahte
BACKGROUND: The increasing threat of antimicrobial resistance combined with the paucity of new classes of antibiotics represents a serious public health challenge. New treatment technologies could, in theory, have a significant impact on the future use of traditional antibiotics, be it by facilitating rational and responsible use or by product substitution in the existing antibiotics markets, including by reducing the incidence of bacterial infections through preventative approaches. The aim of this paper is to assess the potential of alternative technologies in reducing clinical use of and demand for antibiotics, and to briefly indicate which segments of the antibiotics market that might be impacted by these technologies...
2016: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/27799307/nkt-cell-deficient-mice-harbor-an-altered-microbiota-that-fuels-intestinal-inflammation-during-chemically-induced-colitis
#16
Thirumahal Selvanantham, Qiaochu Lin, Cynthia Xinyi Guo, Anuradha Surendra, Stephanie Fieve, Nichole K Escalante, David S Guttman, Catherine J Streutker, Susan J Robertson, Dana J Philpott, Thierry Mallevaey
NKT cells are unconventional T cells that respond to self and microbe-derived lipid and glycolipid Ags presented by the CD1d molecule. Invariant NKT (iNKT) cells influence immune responses in numerous diseases. Although only a few studies have examined their role during intestinal inflammation, it appears that iNKT cells protect from Th1-mediated inflammation but exacerbate Th2-mediated inflammation. Studies using iNKT cell-deficient mice and chemically induced dextran sodium sulfate (DSS) colitis have led to inconsistent results...
October 31, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27799253/hypertension-linked-pathophysiological-alterations-in-the-gut
#17
Monica M Santisteban, Yanfei Qi, Jasenka Zubcevic, Seungbum Kim, Tao Yang, Vinayak Shenoy, Colleen T Cole-Jeffrey, Gilberto O Lobaton, Daniel C Stewart, Andres Rubiano, Chelsey S Simmons, Fernando Garcia-Pereira, Richard D Johnson, Carl J Pepine, Mohan K Raizada
RATIONALE: Sympathetic nervous system control of inflammation plays a central role in hypertension. The gut receives significant sympathetic innervation, is densely populated with a diverse microbial ecosystem, and contains immune cells that greatly impact overall inflammatory homeostasis. Despite this uniqueness, little is known about the involvement of the gut in hypertension. OBJECTIVE: Test the hypothesis that increased sympathetic drive to the gut is associated with increased gut wall permeability, increased inflammatory status, and microbial dysbiosis and that these gut pathological changes are linked to hypertension...
October 31, 2016: Circulation Research
https://www.readbyqxmd.com/read/27795585/the-gut-microbiome-and-its-role-in-obesity
#18
Cindy D Davis
The human body is host to a vast number of microbes, including bacterial, fungal and protozoal microoganisms, which together constitute our microbiota. Evidence is emerging that the intestinal microbiome is intrinsically linked with overall health, including obesity risk. Obesity and obesity-related metabolic disorders are characterized by specific alterations in the composition and function of the human gut microbiome. Mechanistic studies have indicated that the gastrointestinal microbiota can influence both sides of the energy balance equation; namely, as a factor influencing energy utilization from the diet and as a factor that influences host genes that regulate energy expenditure and storage...
July 2016: Nutrition Today
https://www.readbyqxmd.com/read/27769810/roles-for-intestinal-bacteria-viruses-and-fungi-in-pathogenesis-of-inflammatory-bowel-diseases-and-therapeutic-approaches
#19
R Balfour Sartor, Gary D Wu
Intestinal microbiota are involved in the pathogenesis of Crohn's disease, ulcerative colitis, and pouchitis. We review the mechanisms by which these gut bacteria, fungi, and viruses mediate mucosal homeostasis via their composite genes (metagenome) and metabolic products (metabolome). We explain how alterations to their profiles and functions under conditions of dysbiosis contribute to inflammation and effector immune responses that mediate inflammatory bowel diseases (IBD) in humans and enterocolitis in mice...
October 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27757227/new-insights-into-therapeutic-strategies-for-gut-microbiota-modulation-in-inflammatory-diseases
#20
Angélica Thomaz Vieira, Claudio Fukumori, Caroline Marcantonio Ferreira
The interaction between the gut microbiota and the host immune system is very important for balancing and resolving inflammation. The human microbiota begins to form during childbirth; the complex interaction between bacteria and host cells becomes critical for the formation of a healthy or a disease-promoting microbiota. C-section delivery, formula feeding, a high-sugar diet, a high-fat diet and excess hygiene negatively affect the health of the microbiota. Considering that the majority of the global population has experienced at least one of these factors that can lead to inflammatory disease, it is important to understand strategies to modulate the gut microbiota...
June 2016: Clinical & Translational Immunology
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