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Type vi secretion system

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https://www.readbyqxmd.com/read/28217442/whole-genome-sequencing-and-analysis-of-campylobacter-coli-yh502-from-retail-chicken-reveals-a-plasmid-borne-type-vi-secretion-system
#1
Sandeep Ghatak, Yiping He, Sue Reed, Terence Strobaugh, Peter Irwin
Campylobacter is a major cause of foodborne illnesses worldwide. Campylobacter infections, commonly caused by ingestion of undercooked poultry and meat products, can lead to gastroenteritis and chronic reactive arthritis in humans. Whole genome sequencing (WGS) is a powerful technology that provides comprehensive genetic information about bacteria and is increasingly being applied to study foodborne pathogens: e.g., evolution, epidemiology/outbreak investigation, and detection. Herein we report the complete genome sequence of Campylobacter coli strain YH502 isolated from retail chicken in the United States...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/28216293/the-secrets-of-acinetobacter-secretion
#2
REVIEW
Brent S Weber, Rachel L Kinsella, Christian M Harding, Mario F Feldman
Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well defined, but recent research has indicated that secreted proteins may play a major role. A variety of mechanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobacter, including a type II secretion system (T2SS), a type VI secretion system (T6SS), autotransporter, and outer membrane vesicles (OMVs)...
February 16, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28168224/lifestyle-and-horizontal-gene-transfer-mediated-evolution-of-mucispirillum-schaedleri-a-core-member-of-the-murine-gut-microbiota
#3
Alexander Loy, Carina Pfann, Michaela Steinberger, Buck Hanson, Simone Herp, Sandrine Brugiroux, João Carlos Gomes Neto, Mark V Boekschoten, Clarissa Schwab, Tim Urich, Amanda E Ramer-Tait, Thomas Rattei, Bärbel Stecher, David Berry
Mucispirillum schaedleri is an abundant inhabitant of the intestinal mucus layer of rodents and other animals and has been suggested to be a pathobiont, a commensal that plays a role in disease. In order to gain insights into its lifestyle, we analyzed the genome and transcriptome of M. schaedleri ASF 457 and performed physiological experiments to test traits predicted by its genome. Although described as a mucus inhabitant, M. schaedleri has limited capacity for degrading host-derived mucosal glycans and other complex polysaccharides...
January 2017: MSystems
https://www.readbyqxmd.com/read/28165005/killing-by-type-vi-secretion-drives-genetic-phase-separation-and-correlates-with-increased-cooperation
#4
Luke McNally, Eryn Bernardy, Jacob Thomas, Arben Kalziqi, Jennifer Pentz, Sam P Brown, Brian K Hammer, Peter J Yunker, William C Ratcliff
By nature of their small size, dense growth and frequent need for extracellular metabolism, microbes face persistent public goods dilemmas. Genetic assortment is the only general solution stabilizing cooperation, but all known mechanisms structuring microbial populations depend on the availability of free space, an often unrealistic constraint. Here we describe a class of self-organization that operates within densely packed bacterial populations. Through mathematical modelling and experiments with Vibrio cholerae, we show how killing adjacent competitors via the Type VI secretion system (T6SS) precipitates phase separation via the 'Model A' universality class of order-disorder transition mediated by killing...
February 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28143939/blockade-to-pathological-remodeling-of-infarcted-heart-tissue-using-a-porcupine-antagonist
#5
Jesung Moon, Huanyu Zhou, Li-Shu Zhang, Wei Tan, Ying Liu, Shanrong Zhang, Lorraine K Morlock, Xiaoping Bao, Sean P Palecek, Jian Q Feng, Noelle S Williams, James F Amatruda, Eric N Olson, Rhonda Bassel-Duby, Lawrence Lum
The secreted Wnt signaling molecules are essential to the coordination of cell-fate decision making in multicellular organisms. In adult animals, the secreted Wnt proteins are critical for tissue regeneration and frequently contribute to cancer. Small molecules that disable the Wnt acyltransferase Porcupine (Porcn) are candidate anticancer agents in clinical testing. Here we have systematically assessed the effects of the Porcn inhibitor (WNT-974) on the regeneration of several tissue types to identify potentially unwanted chemical effects that could limit the therapeutic utility of such agents...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28114423/contribution-of-the-pseudomonas-fluorescens-mfe01-type-vi-secretion-system-to-biofilm-formation
#6
Mathias Gallique, Victorien Decoin, Corinne Barbey, Thibaut Rosay, Marc G J Feuilloley, Nicole Orange, Annabelle Merieau
Type VI secretion systems (T6SSs) are widespread in Gram-negative bacteria, including Pseudomonas. These macromolecular machineries inject toxins directly into prokaryotic or eukaryotic prey cells. Hcp proteins are structural components of the extracellular part of this machinery. We recently reported that MFE01, an avirulent strain of Pseudomonas fluorescens, possesses at least two hcp genes, hcp1 and hcp2, encoding proteins playing important roles in interbacterial interactions. Indeed, P. fluorescens MFE01 can immobilise and kill diverse bacteria of various origins through the action of the Hcp1 or Hcp2 proteins of the T6SS...
2017: PloS One
https://www.readbyqxmd.com/read/28112271/secretepdb-a-comprehensive-web-based-resource-for-secreted-effector-proteins-of-the-bacterial-types-iii-iv-and-vi-secretion-systems
#7
Yi An, Jiawei Wang, Chen Li, Jerico Revote, Yang Zhang, Thomas Naderer, Morihiro Hayashida, Tatsuya Akutsu, Geoffrey I Webb, Trevor Lithgow, Jiangning Song
Bacteria translocate effector molecules to host cells through highly evolved secretion systems. By definition, the function of these effector proteins is to manipulate host cell biology and the sequence, structural and functional annotations of these effector proteins will provide a better understanding of how bacterial secretion systems promote bacterial survival and virulence. Here we developed a knowledgebase, termed SecretEPDB (Bacterial Secreted Effector Protein DataBase), for effector proteins of type III secretion system (T3SS), type IV secretion system (T4SS) and type VI secretion system (T6SS)...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081443/the-bacterial-t6ss-effector-evpp-prevents-nlrp3-inflammasome-activation-by-inhibiting-the-ca-2-dependent-mapk-jnk-pathway
#8
Hao Chen, Dahai Yang, Fajun Han, Jinchao Tan, Lingzhi Zhang, Jingfan Xiao, Yuanxing Zhang, Qin Liu
Inflammasome activation is an important innate immune defense mechanism against bacterial infection, and in return, bacteria express virulence determinants that counteract inflammasome activation. Many such effectors are secreted into host cells via specialized bacterial secretion systems. Here, the intracellular pathogenic bacterium Edwardsiella tarda was demonstrated to activate NLRC4 and NLRP3 inflammasomes via a type III secretion system (T3SS), and to inhibit NLRP3 inflammasome via a type VI secretion system (T6SS), indicating the antagonistic roles of these systems in inflammasome signaling...
January 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28081441/warfare-between-host-immunity-and-bacterial-weapons
#9
Manda Yu, Erh-Min Lai
Bacterial pathogens deploy protein secretion systems to facilitate infection and colonization of their hosts. In this issue of Cell Host & Microbe, Chen et al. (2017) report a new role for a type VI secretion effector in promoting bacterial colonization by preventing inflammasome activation induced by a type III secretion system.
January 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28077405/vrprofile-gene-cluster-detection-based-profiling-of-virulence-and-antibiotic-resistance-traits-encoded-within-genome-sequences-of-pathogenic-bacteria
#10
Jun Li, Cui Tai, Zixin Deng, Weihong Zhong, Yongqun He, Hong-Yu Ou
VRprofile is a Web server that facilitates rapid investigation of virulence and antibiotic resistance genes, as well as extends these trait transfer-related genetic contexts, in newly sequenced pathogenic bacterial genomes. The used backend database MobilomeDB was firstly built on sets of known gene cluster loci of bacterial type III/IV/VI/VII secretion systems and mobile genetic elements, including integrative and conjugative elements, prophages, class I integrons, IS elements and pathogenicity/antibiotic resistance islands...
January 10, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28060574/the-hcp-proteins-fused-with-diverse-extended-toxin-domains-represent-a-novel-pattern-of-antibacterial-effectors-in-type-vi-secretion-systems
#11
Jiale Ma, Zihao Pan, Jinhu Huang, Min Sun, Chengping Lu, Huochun Yao
The type VI secretion system (T6SS) is a widespread molecular weapon deployed by many bacterial species to target eukaryotic host cells or rival bacteria. Using a dynamic injection mechanism, diverse effectors can be delivered by T6SS directly into recipient cells. Here, we report a new family of T6SS effectors encoded by extended Hcps carrying diverse toxin domains. Bioinformatic analyses revealed that these Hcps with C-terminal extension toxins, designated as Hcp-ET, exist widely in the Enterobacteriaceae...
January 6, 2017: Virulence
https://www.readbyqxmd.com/read/28060573/francisella-tularensis-type-vi-secretion-system-comes-of-age
#12
Petra Spidlova, Jiri Stulik
No abstract text is available yet for this article.
January 6, 2017: Virulence
https://www.readbyqxmd.com/read/28045455/the-pseudomonas-putida-t6ss-is-a-plant-warden-against-phytopathogens
#13
Patricia Bernal, Luke P Allsopp, Alain Filloux, María A Llamas
Bacterial type VI secretion systems (T6SSs) are molecular weapons designed to deliver toxic effectors into prey cells. These nanomachines have an important role in inter-bacterial competition and provide advantages to T6SS active strains in polymicrobial environments. Here we analyze the genome of the biocontrol agent Pseudomonas putida KT2440 and identify three T6SS gene clusters (K1-, K2- and K3-T6SS). Besides, 10 T6SS effector-immunity pairs were found, including putative nucleases and pore-forming colicins...
January 3, 2017: ISME Journal
https://www.readbyqxmd.com/read/28027803/rules-of-engagement-the-type-vi-secretion-system-in-vibrio-cholerae
#14
REVIEW
Avatar Joshi, Benjamin Kostiuk, Andrew Rogers, Jennifer Teschler, Stefan Pukatzki, Fitnat H Yildiz
Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins. Vibrio cholerae is a Gram-negative pathogen that can use its T6SS during antagonistic interactions with neighboring prokaryotic and eukaryotic competitors. The T6SS not only promotes V. cholerae's survival during its aquatic and host life cycles, but also influences its evolution by facilitating horizontal gene transfer...
December 24, 2016: Trends in Microbiology
https://www.readbyqxmd.com/read/27982111/dual-seq-transcriptomics-reveals-the-battle-for-iron-during-pseudomonas-aeruginosa-acute-murine-pneumonia
#15
F Heath Damron, Amanda G Oglesby-Sherrouse, Angela Wilks, Mariette Barbier
Determining bacterial gene expression during infection is fundamental to understand pathogenesis. In this study, we used dual RNA-seq to simultaneously measure P. aeruginosa and the murine host's gene expression and response to respiratory infection. Bacterial genes encoding products involved in metabolism and virulence were differentially expressed during infection and the type III and VI secretion systems were highly expressed in vivo. Strikingly, heme acquisition, ferric-enterobactin transport, and pyoverdine biosynthesis genes were found to be significantly up-regulated during infection...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27974393/temperature-regulated-expression-of-type-vi-secretion-systems-in-fish-pathogen-pseudomonas-plecoglossicida-revealed-by-comparative-secretome-analysis
#16
Zhen Tao, Tao Zhou, Suming Zhou, Guoliang Wang
Pseudomonas plecoglossicida is a facultative fish pathogen. Recent studies showed that P. plecoglossicida infection in fish was associated with temperature. The aim of this study was to compare the secretomes of P. plecoglossicida cultured in vitro at representative temperatures for pathogenic (20°C) and less pathogenic (30°C) phenotypes. Thirteen proteins in the culture supernatants of P. plecoglossicida showed significant difference in abundance at 20 vs. 30°C. Four proteins were strongly increased at 20°C, including two hemolysin co-regulated proteins (Hcp) that are part of the bacterial type VI secretion system (T6SS), flagellin and an unknown protein...
November 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27939153/whole-genome-comparative-analysis-of-the-pathogen-piscirickettsia-salmonis
#17
Cristian Bravo, Victor Martinez
The intracellular pathogen Piscirickettsia salmonis is the etiological agent of piscirickettsiosis, the most important bacterial disease that affects the Chilean salmon industry. Despite its importance, little is known regarding the biology of the pathogen. In this study, recently published sequencing data was used in order to characterize the genome of P. salmonis, defining groups of genes associated with bacterial processes such as, invasion and intracellular survival. Moreover, one Chilean P. salmonis isolate, which is known to be virulent at in vitro and in vivo assays, was sequenced, assembled, annotated and functionally characterized...
November 30, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27920034/domestication-of-a-housekeeping-transglycosylase-for-assembly-of-a-type-vi-secretion-system
#18
Yoann G Santin, Eric Cascales
The type VI secretion system (T6SS) is an anti-bacterial weapon comprising a contractile tail anchored to the cell envelope by a membrane complex. The TssJ, TssL, and TssM proteins assemble a 1.7-MDa channel complex that spans the cell envelope, including the peptidoglycan layer. The electron microscopy structure of the TssJLM complex revealed that it has a diameter of ~18 nm in the periplasm, which is larger than the size of peptidoglycan pores (~2 nm), hence questioning how the T6SS membrane complex crosses the peptidoglycan layer...
January 2017: EMBO Reports
https://www.readbyqxmd.com/read/27915248/comparative-proteomic-analysis-unravels-a-role-for-esrb-in-the-regulation-of-reactive-oxygen-species-stress-responses-in-edwardsiella-piscicida
#19
Kaiyu Yin, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang
As a leading pathogen, Edwardsiella piscicida can cause hemorrhagic septicemia in fish and gastro-intestinal infections in humans. The two-component regulatory system EsrA-EsrB plays essential roles in pathogenesis through the type III and type VI secretion systems, and hemolysin production in E. piscicida It is unclear whether other virulence- or stress response-associated genes are regulated by EsrA-EsrB. In this study, the proteomes of wild-type E. piscicida EIB202 and esrB mutant strains were compared to reveal EsrB regulon components after growth in Luria-Bertani broth (LB)...
January 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27871130/paar-rhs-proteins-harbor-various-c-terminal-toxins-to-diversify-the-antibacterial-pathways-of-type-vi-secretion-systems
#20
Jiale Ma, Min Sun, Wenyang Dong, Zihao Pan, Chengping Lu, Huochun Yao
The type VI secretion system (T6SS) of bacteria plays a key role in competing for specific niches by the contact-dependent killing of competitors. Recently, Rhs proteins with polymorphic C-terminal toxin-domains that inhibit or kill neighboring cells were identified. In this report, we identified a novel Rhs with an MPTase4 (Metallopeptidase-4) domain (designated as Rhs-CT1) that showed an antibacterial effect via T6SS in Escherichia coli. We managed to develop a specific strategy by matching the diagnostic domain-architecture of Rhs-CT1 (Rhs with an N-terminal PAAR-motif and a C-terminal toxin domain) for effector retrieval and discovered a series of Rhs-CTs in E...
November 21, 2016: Environmental Microbiology
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