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Virginia L Miller

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https://www.readbyqxmd.com/read/27844039/increased-prevalence-of-autoimmune-disease-within-c9-and-ftd-mnd-cohorts-completing-the-picture
#1
Zachary A Miller, Virginia E Sturm, Gamze Balci Camsari, Anna Karydas, Jennifer S Yokoyama, Lea T Grinberg, Adam L Boxer, Howard J Rosen, Katherine P Rankin, Maria Luisa Gorno-Tempini, Giovanni Coppola, Daniel H Geschwind, Rosa Rademakers, William W Seeley, Neill R Graff-Radford, Bruce L Miller
OBJECTIVE: To determine the prevalence of autoimmune disease in symptomatic C9ORF72 (C9) mutation carriers and frontotemporal dementia with motor neuron disease (FTD/MND) cohorts. METHODS: In this case-control study, we reviewed the clinical histories of 66 patients with FTD/MND and 57 symptomatic C9 carriers (24 overlapping cases), a total of 99 charts, for history of autoimmune disease. The prevalence of autoimmune disease in C9 and FTD/MND cohorts was determined by χ(2) and Fisher exact comparisons between the combined C9 and FTD/MND group with normal control, Alzheimer disease, and progressive supranuclear palsy cohorts, as well as comparisons within C9 and FTD/MND cohorts...
December 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27790364/sex-and-gender-medical-education-summit-a-roadmap-for-curricular-innovation
#2
EDITORIAL
Eliza L Chin, Marley Hoggatt, Alyson J McGregor, Mary K Rojek, Kimberly Templeton, Robert Casanova, Wendy S Klein, Virginia M Miller, Marjorie Jenkins
The Sex and Gender Medical Education Summit: a roadmap for curricular innovation was a collaborative initiative of the American Medical Women's Association, Laura W. Bush Institute for Women's Health, Mayo Clinic, and Society for Women's Health Research (www.sgbmeducationsummit.com). It was held on October 18-19, 2015 to provide a unique venue for collaboration among nationally and internationally renowned experts in developing a roadmap for the incorporation of sex and gender based concepts into medical education curricula...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27775761/state-level-cancer-mortality-attributable-to-cigarette-smoking-in-the-united-states
#3
Joannie Lortet-Tieulent, Ann Goding Sauer, Rebecca L Siegel, Kimberly D Miller, Farhad Islami, Stacey A Fedewa, Eric J Jacobs, Ahmedin Jemal
Importance: State-specific information about the health burden of smoking is valuable because state-level initiatives are at the forefront of tobacco control. Smoking-attributable cancer mortality estimates are currently available nationally and by cancer, but not by state. Objective: To calculate the proportion of cancer deaths among adults 35 years and older that were attributable to cigarette smoking in 2014 in each state and the District of Columbia. Design, Setting, and Participants: The population-attributable fraction (PAF) of cancer deaths due to cigarette smoking was computed using relative risks for 12 smoking-related cancers (acute myeloid leukemia and cancers of the oral cavity and pharynx; esophagus; stomach; colorectum; liver; pancreas; larynx; trachea, lung, and bronchus; cervix uteri; kidney and renal pelvis; and urinary bladder) from large US prospective studies and state-specific smoking prevalence data from the Behavioral Risk Factor Surveillance System...
October 24, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27707553/preeclampsia-and-esrd-the-role-of-shared-risk-factors
#4
Andrea G Kattah, Dawn C Scantlebury, Sanket Agarwal, Michelle M Mielke, Walter A Rocca, Amy L Weaver, Lisa E Vaughan, Virginia M Miller, Tracey L Weissgerber, Wendy White, Vesna D Garovic
BACKGROUND: Several registry-based studies, using diagnostic codes, have suggested that preeclampsia is a risk factor for end-stage renal disease (ESRD). However, because the 2 diseases share risk factors, the true nature of their association remains uncertain. Our goals were to conduct a population-based study to determine the magnitude of the association between preeclampsia and ESRD and evaluate the role of shared risk factors. STUDY DESIGN: Population-based nested case-control study...
October 1, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27698154/cognition-and-neuropsychiatry-in-behavioral-variant-frontotemporal-dementia-by-disease-stage
#5
Maxime Bertoux, Marie Sarazin, Florence Pasquier, Michel Bottlaender, Leonardo Cruz de Souza, Eneida Mioshi, Michael Hornberger, Kamalini G Ranasinghe, Katherine P Rankin, Iryna V Lobach, Joel H Kramer, Virginia E Sturm, Brianne M Bettcher, Katherine Possin, S Christine You, Amanda K Lamarre, Tal Shany-Ur, Melanie L Stephens, David C Perry, Suzee E Lee, Zachary A Miller, Maria L Gorno-Tempini, Howard J Rosen, Adam Boxer, William W Seeley, Gil D Rabinovici, Keith A Vossel, Bruce L Miller
No abstract text is available yet for this article.
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27693001/accelerated-accumulation-of-multimorbidity-after-bilateral-oophorectomy-a-population-based-cohort-study
#6
Walter A Rocca, Liliana Gazzuola-Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, James L Kirkland, Elizabeth A Stewart, Virginia M Miller
OBJECTIVE: To study the association between bilateral oophorectomy and the rate of accumulation of multimorbidity. PATIENTS AND METHODS: In this historical cohort study, the Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy before age 50 years between January 1, 1988, and December 31, 2007, in Olmsted County, Minnesota. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy...
November 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27682203/considering-sex-as-a-biological-variable-in-preclinical-research
#7
Leah R Miller, Cheryl Marks, Jill B Becker, Patricia D Hurn, Wei-Jung Chen, Teresa Woodruff, Margaret M McCarthy, Farida Sohrabji, Londa Schiebinger, Cora Lee Wetherington, Susan Makris, Arthur P Arnold, Gillian Einstein, Virginia M Miller, Kathryn Sandberg, Susan Maier, Terri L Cornelison, Janine A Clayton
In June 2015, the National Institutes of Health (NIH) released a Guide notice (NOT-OD-15-102) that highlighted the expectation of the NIH that the possible role of sex as a biologic variable be factored into research design, analyses, and reporting of vertebrate animal and human studies. Anticipating these guidelines, the NIH Office of Research on Women's Health, in October 2014, convened key stakeholders to discuss methods and techniques for integrating sex as a biologic variable in preclinical research. The workshop focused on practical methods, experimental design, and approaches to statistical analyses in the use of both male and female animals, cells, and tissues in preclinical research...
September 28, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27616478/bi-allelic-mutations-in-pkd1l1-are-associated-with-laterality-defects-in-humans
#8
Francesco Vetrini, Lisa C A D'Alessandro, Zeynep C Akdemir, Alicia Braxton, Mahshid S Azamian, Mohammad K Eldomery, Kathryn Miller, Chelsea Kois, Virginia Sack, Natasha Shur, Asha Rijhsinghani, Jignesh Chandarana, Yan Ding, Judy Holtzman, Shalini N Jhangiani, Donna M Muzny, Richard A Gibbs, Christine M Eng, Neil A Hanchard, Tamar Harel, Jill A Rosenfeld, John W Belmont, James R Lupski, Yaping Yang
Disruption of the establishment of left-right (L-R) asymmetry leads to situs anomalies ranging from situs inversus totalis (SIT) to situs ambiguus (heterotaxy). The genetic causes of laterality defects in humans are highly heterogeneous. Via whole-exome sequencing (WES), we identified homozygous mutations in PKD1L1 from three affected individuals in two unrelated families. PKD1L1 encodes a polycystin-1-like protein and its loss of function is known to cause laterality defects in mouse and medaka fish models...
October 6, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27613206/emerging-tick-borne-rickettsia-and-ehrlichia-at-joint-base-langley-eustis-fort-eustis-virginia
#9
Melissa K Miller, Ju Jiang, Melissa Truong, Tamasin Yarina, Holly Evans, Timothy P Christensen, Allen L Richards
Four species of ticks known to parasitize humans (Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Amblyomma maculatum (Gulf Coast tick), and Ixodes scapularis (black-legged tick)) were collected at Joint Base Langley-Eustis, Fort Eustis, Virginia during 2009. These ticks were tested individually (adults and nymphs) and in pools of 15 (larvae) for pathogens of public health importance within the genera: Rickettsia, Borrelia, and Ehrlichia, by quantitative real-time polymerase chain reaction (qPCR) assays and, where appropriate, multilocus sequence typing (MLST)...
October 2016: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/27552103/comparing-volume-loss-in-neuroanatomical-regions-of-emotion-versus-regions-of-cognition-in-healthy-aging
#10
Peter S Pressman, Yuliana Noniyeva, Nick Bott, Shubir Dutt, Virginia Sturm, Bruce L Miller, Joel H Kramer
Many emotional functions are relatively preserved in aging despite declines in several cognitive domains and physical health. High levels of happiness exist even among centenarians. To address the hypothesis of whether preservation of emotional function in healthy aging may relate to different rates of age-related volume loss across brain structures, we performed two volumetric analyses on structural magnetic resonance neuroimaging of a group of healthy aging research participants using Freesurfer version 5...
2016: PloS One
https://www.readbyqxmd.com/read/27525416/copd-exacerbation-biomarkers-validated-using-multiple-reaction-monitoring-mass-spectrometry
#11
Janice M Leung, Virginia Chen, Zsuzsanna Hollander, Darlene Dai, Scott J Tebbutt, Shawn D Aaron, Kathy L Vandemheen, Stephen I Rennard, J Mark FitzGerald, Prescott G Woodruff, Stephen C Lazarus, John E Connett, Harvey O Coxson, Bruce Miller, Christoph Borchers, Bruce M McManus, Raymond T Ng, Don D Sin
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in considerable morbidity and mortality. However, there are no objective biomarkers to diagnose AECOPD. METHODS: We used multiple reaction monitoring mass spectrometry to quantify 129 distinct proteins in plasma samples from patients with COPD. This analytical approach was first performed in a biomarker cohort of patients hospitalized with AECOPD (Cohort A, n = 72). Proteins differentially expressed between AECOPD and convalescent states were chosen using a false discovery rate <0...
2016: PloS One
https://www.readbyqxmd.com/read/27500329/second-curettage-for-low-risk-nonmetastatic-gestational-trophoblastic-neoplasia
#12
Raymond J Osborne, Virginia L Filiaci, Julian C Schink, Robert S Mannel, Kian Behbakht, James S Hoffman, Nick M Spirtos, John K Chan, John A Tidy, David S Miller
OBJECTIVE: To evaluate the efficacy and safety of second uterine curettage in lieu of chemotherapy for patients with low-risk, nonmetastatic gestational trophoblastic neoplasia (GTN) and to evaluate whether response to second curettage is independent of patient age, World Health Organization (WHO) risk score, registration human chorionic gonadotropin (hCG) level, lesion size, and depth of myometrial invasion measured on ultrasound examination. METHODS: This was a cooperative group multicenter prospective phase II study...
September 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27496358/preparing-postbaccalaureates-for-entry-and-success-in-biomedical-phd-programs
#13
Joshua D Hall, Jessica R Harrell, Kimberley W Cohen, Virginia L Miller, Patricia V Phelps, Jeanette G Cook
Certain racial and ethnic groups, individuals with disabilities, and those from low socioeconomic backgrounds remain underrepresented (UR) in the biomedical sciences. This underrepresentation becomes more extreme at each higher education stage. To support UR scholars during the critical transition from baccalaureate to PhD, we established an intensive, 1-yr postbaccalaureate training program. We hypothesized that this intervention would strengthen each participant's competitiveness for leading PhD programs and build a foundation of skills and self-efficacy important for success during and after graduate school...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27473135/effects-of-hormone-therapy-on-brain-structure-a-randomized-controlled-trial
#14
Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Samantha M Zuk, Jeffrey L Gunter, Carey E Gleason, Whitney Wharton, N Maritza Dowling, Prashanthi Vemuri, Matthew L Senjem, Lynne T Shuster, Kent R Bailey, Walter A Rocca, Clifford R Jack, Sanjay Asthana, Virginia M Miller
OBJECTIVE: To investigate the effects of hormone therapy on brain structure in a randomized, double-blinded, placebo-controlled trial in recently postmenopausal women. METHODS: Participants (aged 42-56 years, within 5-36 months past menopause) in the Kronos Early Estrogen Prevention Study were randomized to (1) 0.45 mg/d oral conjugated equine estrogens (CEE), (2) 50 μg/d transdermal 17β-estradiol, or (3) placebo pills and patch for 48 months. Oral progesterone (200 mg/d) was given to active treatment groups for 12 days each month...
August 30, 2016: Neurology
https://www.readbyqxmd.com/read/27429218/distinct-subtypes-of-behavioral-variant-frontotemporal-dementia-based-on-patterns-of-network-degeneration
#15
Kamalini G Ranasinghe, Katherine P Rankin, Peter S Pressman, David C Perry, Iryna V Lobach, William W Seeley, Giovanni Coppola, Anna M Karydas, Lea T Grinberg, Tal Shany-Ur, Suzee E Lee, Gil D Rabinovici, Howard J Rosen, Maria Luisa Gorno-Tempini, Adam L Boxer, Zachary A Miller, Winston Chiong, Mary DeMay, Joel H Kramer, Katherine L Possin, Virginia E Sturm, Brianne M Bettcher, Michael Neylan, Diana D Zackey, Lauren A Nguyen, Robin Ketelle, Nikolas Block, Teresa Q Wu, Alison Dallich, Natanya Russek, Alyssa Caplan, Daniel H Geschwind, Keith A Vossel, Bruce L Miller
IMPORTANCE: Clearer delineation of the phenotypic heterogeneity within behavioral variant frontotemporal dementia (bvFTD) will help uncover underlying biological mechanisms and improve clinicians' ability to predict disease course and to design targeted management strategies. OBJECTIVE: To identify subtypes of bvFTD syndrome based on distinctive patterns of atrophy defined by selective vulnerability of specific functional networks targeted in bvFTD using statistical classification approaches...
September 1, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27272582/association-between-a-single-general-anesthesia-exposure-before-age-36-months-and-neurocognitive-outcomes-in-later-childhood
#16
MULTICENTER STUDY
Lena S Sun, Guohua Li, Tonya L K Miller, Cynthia Salorio, Mary W Byrne, David C Bellinger, Caleb Ing, Raymond Park, Jerilynn Radcliffe, Stephen R Hays, Charles J DiMaggio, Timothy J Cooper, Virginia Rauh, Lynne G Maxwell, Ahrim Youn, Francis X McGowan
IMPORTANCE: Exposure of young animals to commonly used anesthetics causes neurotoxicity including impaired neurocognitive function and abnormal behavior. The potential neurocognitive and behavioral effects of anesthesia exposure in young children are thus important to understand. OBJECTIVE: To examine if a single anesthesia exposure in otherwise healthy young children was associated with impaired neurocognitive development and abnormal behavior in later childhood...
June 7, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27163830/early-postmenopausal-transdermal-17%C3%AE-estradiol-therapy-and-amyloid-%C3%AE-deposition
#17
Kejal Kantarci, Val J Lowe, Timothy G Lesnick, Nirubol Tosakulwong, Kent R Bailey, Julie A Fields, Lynne T Shuster, Samantha M Zuk, Matthew L Senjem, Michelle M Mielke, Carey Gleason, Clifford R Jack, Walter A Rocca, Virginia M Miller
BACKGROUND: It remains controversial whether hormone therapy in recently postmenopausal women modifies the risk of Alzheimer's disease (AD). OBJECTIVE: To investigate the effects of hormone therapy on amyloid-β deposition in recently postmenopausal women. METHODS: Participants within 5-36 months past menopause in the Kronos Early Estrogen Prevention Study, a randomized, double blinded placebo-controlled clinical trial, were randomized to: 1) 0...
May 7, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27148847/insular-atrophy-and-diminished-disgust-reactivity
#18
Alice Verstaen, Janet A Eckart, Luma Muhtadie, Marcela C Otero, Virginia E Sturm, Claudia M Haase, Bruce L Miller, Robert W Levenson
Disgust is an emotion that helps us deal with potential contamination (Rozin & Fallon, 1987). It produces a distinctive facial expression (e.g., wrinkled nose) and a physiological response that is accompanied by strong visceral sensations (e.g., nausea). Given the important role that the anterior insula plays in processing and integrating visceral information (Craig, 2009), it is likely to be centrally involved in disgust. Despite this, few studies have examined the link between insular degeneration and the experience, physiology, and expression of disgust...
September 2016: Emotion
https://www.readbyqxmd.com/read/27071080/dominant-hemisphere-lateralization-of-cortical-parasympathetic-control-as-revealed-by-frontotemporal-dementia
#19
Christine C Guo, Virginia E Sturm, Juan Zhou, Efstathios D Gennatas, Andrew J Trujillo, Alice Y Hua, Richard Crawford, Lara Stables, Joel H Kramer, Katherine Rankin, Robert W Levenson, Howard J Rosen, Bruce L Miller, William W Seeley
The brain continuously influences and perceives the physiological condition of the body. Related cortical representations have been proposed to shape emotional experience and guide behavior. Although previous studies have identified brain regions recruited during autonomic processing, neurological lesion studies have yet to delineate the regions critical for maintaining autonomic outflow. Even greater controversy surrounds hemispheric lateralization along the parasympathetic-sympathetic axis. The behavioral variant of frontotemporal dementia (bvFTD), featuring progressive and often asymmetric degeneration that includes the frontoinsular and cingulate cortices, provides a unique lesion model for elucidating brain structures that control autonomic tone...
April 26, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27044629/the-ysrs-paralog-dygs-has-the-capacity-to-activate-expression-of-the-yersinia-enterocolitica-ysa-type-iii-secretion-system
#20
Kimberly A Walker, Lauren A Griggs, Markus Obrist, Addys Bode, R Patrick Summers, Virginia L Miller
UNLABELLED: The Yersinia enterocolitica Ysa type III secretion system (T3SS) is associated with intracellular survival, and, like other characterized T3SSs, it is tightly controlled. Expression of the ysa genes is only detected following growth at low temperatures (26°C) and in high concentrations of sodium chloride (290 mM) in the medium. The YsrSTR phosphorelay (PR) system is required for ysa expression and likely responds to NaCl. During our investigations into the Ysr PR system, we discovered that genes YE3578 and YE3579 are remarkably similar to ysrR and ysrS, respectively, and are probably a consequence of a gene duplication event...
June 15, 2016: Journal of Bacteriology
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