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Miller vl

Michael A Trevino, Adam J Sterczala, Jonathan D Miller, Mandy E Wray, Hannah L Dimmick, Anthony B Ciccone, Joseph P Weir, Philip M Gallagher, Andrew C Fry, Trent J Herda
AIM: To investigate the relationships between motor unit action potential amplitudes (MUAPAMP ), muscle cross-sectional area (mCSA) and composition (mEI), percent myosin heavy chain (%MHC) areas, and sex in the vastus lateralis (VL). METHODS: Ten males and 10 females performed a submaximal isometric trapezoid muscle action that included a linearly increasing, steady torque at 40% maximal voluntary contraction, and linearly decreasing segments. Surface electromyographic decomposition techniques were utilized to determine MUAPAMPS in relation to recruitment thresholds (RT)...
June 16, 2018: Acta Physiologica
Ruth Pereira, David A Ludwig, Sunil Mathew, Claudia Flores, Sady Dominguez, Ivan Gonzalez, Delia Rivera-Hernandez, Gwendolyn B Scott, Charles D Mitchell
Background: Less than optimal adherence with antiretroviral therapy occurs commonly among human immunodeficiency virus HIV)-infected youth. In this study, our object was to identify patterns in the prefailure measurement of viral load (VL) that can reliably predict virological failure (VF) in HIV perinatally infected youth on highly active antiretroviral therapy (HAART). Methods: We conducted a retrospective chart review of HIV-infected youth with low-level viremia (LLV), defined as an HIV VL between the lower limits of detection (20-75 copies/mL) and 1000 copies/mL...
May 19, 2018: Journal of the Pediatric Infectious Diseases Society
Maganizo B Chagomerana, William C Miller, Jennifer H Tang, Irving F Hoffman, Bryan C Mthiko, Jacob Phulusa, Mathias John, Allan Jumbe, Mina C Hosseinipour
BACKGROUND: Effective antiretroviral therapy during pregnancy minimizes the risk of vertical HIV transmission. Some women present late in their pregnancy for first antenatal visit; whether these women achieve viral suppression by delivery and how suppression varies with time on ART is unclear. METHODS: We conducted a prospective cohort study of HIV-infected pregnant women initiating antiretroviral therapy for the first time at Bwaila Hospital in Lilongwe, Malawi from June 2015 to November 2016...
2018: PloS One
Marjan Islam, Navitha Ramesh, Samuel Kolman, Sanjana Koshy, Matthew Frank, Nadim Salomon, Albert Miller, Mary Harris
PURPOSE: The antiretroviral therapy era has shifted the epidemiology of HIV-associated diseases, increasing the recognition of non-infectious pulmonary complications secondary to HIV. We aimed to determine the association between CD4+ , viral load, and pulmonary function in individuals with uncontrolled HIV, and determine how changes in these parameters are associated with pulmonary function longitudinally. METHODS: This is a retrospective observational study of individuals with HIV who underwent pulmonary function testing in an urban medical center between August 1997 and November 2015...
October 2017: Lung
Ruthiran Kugathasan, Dami A Collier, Lewis J Haddow, Kate El Bouzidi, Simon G Edwards, Jonathan D Cartledge, Robert F Miller, Ravindra K Gupta
Background: Human immunodeficiency virus type 1 (HIV-1) can replicate independently in extravascular compartments such as the central nervous system, resulting in either cerebrospinal fluid (CSF) discordance (viral load [VL] in CSF 0.5 log10 copies HIV-1 RNA greater than plasma VL) or escape (detection of HIV VL >50 copies/mL in CSF in patients with suppressed plasma VL <50 copies/mL). Both discordance and escape may be associated with neurological symptoms. We explored risk factors for CSF discordance and escape in patients presenting with diverse neurological problems...
April 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Eric M Mosier, Trent J Herda, Michael A Trevino, Jonathan D Miller
INTRODUCTION: The purpose of this study was to determine the effects of vibration (VIB) on motor unit (MU) behavior of the vastus lateralis (VL) muscle during a 40% maximal voluntary contraction (MVC). METHODS: Eleven healthy (age 21.3 ± 2.6 years) individuals participated in the study. Surface electromyography (EMG) data were recorded from the VL during isometric trapezoidal muscle contractions at 40% MVC. Firing events of single MUs and EMG amplitude were reported for the first, middle, and final seconds of a 12-second steady force segment at 40% MVC...
April 2017: Muscle & Nerve
Sarah E Rutstein, Mina C Hosseinipour, Morris Weinberger, Stephanie B Wheeler, Andrea K Biddle, Carole L Wallis, Pachamuthu Balakrishnan, John W Mellors, Mariza Morgado, Shanmugam Saravanan, Srikanth Tripathy, Saran Vardhanabhuti, Joseph J Eron, William C Miller
BACKGROUND: In resource-limited settings, where resistance testing is unavailable, confirmatory testing for patients with high viral loads (VL) delays antiretroviral therapy (ART) switches for persons with resistance. We developed a risk score algorithm to predict need for ART change by identifying resistance among persons with persistently elevated VL. METHODS: We analyzed data from a Phase IV open-label trial. Using logistic regression, we identified demographic and clinical characteristics predictive of need for ART change among participants with VLs ≥1000 copies/ml, and assigned model-derived scores to predictors...
June 13, 2016: BMC Infectious Diseases
Alexandra M V Wennberg, Adam P Spira, Corinne Pettigrew, Anja Soldan, Vadim Zipunnikov, George W Rebok, Allen D Roses, Michael W Lutz, Michael M Miller, Madhav Thambisetty, Marilyn S Albert
Type II diabetes mellitus (DM) increases risk for cognitive decline and is associated with brain atrophy in older demented and non-demented individuals. We investigated (1) the cross-sectional association between fasting blood glucose level and cortical thickness in a sample of largely middle-aged, cognitively normal adults, and (2) whether these associations were modified by genes associated with both lipid processing and dementia. To explore possible modifications by genetic status, we investigated the interaction between blood glucose levels and the apolipoprotein E (APOE) ε4 allele and the translocase of the outer mitochondrial membrane (TOMM) 40 '523 genotype on cortical thickness...
June 15, 2016: Journal of the Neurological Sciences
Michael A Trevino, Trent J Herda, Andrew C Fry, Philip M Gallagher, John P Vardiman, Eric M Mosier, Jonathan D Miller
This study examined correlations between type I percent myosin heavy chain isoform content (%MHC) and mechanomyographic amplitude (MMGRMS) during isometric muscle actions. Fifteen (age=21.63±2.39) participants performed 40% and 70% maximal voluntary contractions (MVC) of the leg extensors that included increasing, steady force, and decreasing segments. Muscle biopsies were collected and MMG was recorded from the vastus lateralis. Linear regressions were fit to the natural-log transformed MMGRMS-force relationships (increasing and decreasing segments) and MMGRMS was selected at the targeted force level during the steady force segment...
June 2016: Journal of Electromyography and Kinesiology
T J Herda, J D Miller, M A Trevino, E M Mosier, P M Gallagher, A C Fry, J P Vardiman
AIM: To investigate the change in motor unit (MU) firing rates (FR) at de-recruitment relative to recruitment and the relation to % type I myosin heavy chain isoform content (type I %MHC) of the vastus lateralis (VL) in vivo. METHODS: Ten subjects performed a 22-s submaximal isometric trapezoid muscle action that included a linearly increasing, steady force at 50% maximal voluntary contraction, and linearly decreasing segments. Surface electromyographic signals were collected from the VL and were decomposed into constituent MU action potentials trains...
April 2016: Acta Physiologica
S E Rutstein, C E Golin, S B Wheeler, D Kamwendo, M C Hosseinipour, M Weinberger, W C Miller, A K Biddle, A Soko, M Mkandawire, R Mwenda, A Sarr, S Gupta, R Mataya
Scale-up of viral load (VL) monitoring for HIV-infected patients on antiretroviral therapy (ART) is a priority in many resource-limited settings, and ART providers are critical to effective program implementation. We explored provider-perceived barriers and facilitators of VL monitoring. We interviewed all providers (n = 17) engaged in a public health evaluation of dried blood spots for VL monitoring at five ART clinics in Malawi. All ART clinics were housed within district hospitals. We grouped themes at patient, provider, facility, system, and policy levels...
2016: AIDS Care
John Vassiliadis, Alex Tzannes, Kerry Hitos, Jessica Brimble, Toby Fogg
OBJECTIVE: To investigate the first pass success rate, airway grade and complications in two tertiary EDs with the C-MAC video laryngoscope (VL), when compared with standard direct laryngoscopy (DL). METHODS: This was a retrospective analysis of prospectively collected data entered into an airway registry database in the EDs of Royal North Shore and St George Hospitals (SGH) over a 30 month period. Doctors had the choice of using either DL using a Macintosh or Miller blade or a C-MAC VL for the intubation...
April 2015: Emergency Medicine Australasia: EMA
Ronald Croce, John Miller, Kent Chamberlin, David Filipovic, Wayne Smith
INTRODUCTION: We investigated the effect of contraction intensity [100%, 75%, 50%, and 25% maximum voluntary contraction (MVC)] and movement velocity (50°, 100°, 200°, and 400°/s) on surface electromyography root mean square amplitude (SEMGRMS ) and median frequency (SEMGMDF ) of rectus femoris (RF), vastus lateralis (VL), and vastus medialis (VM). METHODS: SEMGs during knee extension were resolved into their respective frequencies using wavelet transformations...
November 2014: Muscle & Nerve
Ravindra K Gupta, Michael Marks, Simon G Edwards, Katie Smith, Katie Fletcher, Siow-Ming Lee, Alan Ramsay, Andrew J Copas, Robert F Miller
BACKGROUND: The incidence of Hodgkin lymphoma (HL) among HIV-infected individuals remains unchanged since the introduction of combination antiretroviral therapy (cART). Recent epidemiological data suggest that CD4 count decline over a year is associated with subsequent diagnosis of HL. In an era of economic austerity monitoring the efficacy of cART by CD4 counts may no longer be required where CD4 count>350 cells/µl and viral load is suppressed (<50 copies/ml). METHODS: We sought to establish among our HIV outpatient cohort whether a CD4 count decline prior to diagnosis of HL, whether any decline was greater than in patients without the diagnosis, and also whether other clinical or biochemical indices were reliably associated with the diagnosis...
2014: PloS One
Mark D Ricard, Patrick Hills-Meyer, Michael G Miller, Timothy J Michael
The purpose of this study was to compare the effects of bicycle seat tube angles (STA) of (72° and 82°) on power production and EMG of the vastus laeralis (VL), vastus medialis (VM), semimembranous (SM), biceps femoris (BF) during a Wingate test (WAT). Twelve experienced cyclists performed a WAT at each STA. Repeated measures ANOVA was used to identify differences in muscular activation by STA. EMG variables were normalized to isometric maximum voluntary contraction (MVC). Paired t-tests were used to test the effects of STA on: peak power, average power, minimum power and percent power drop...
2006: Journal of Sports Science & Medicine
G A Orliaguet, R-M Blot, N Bourdaud, M Egan, E Dogaru, N Salvi, O Gall, P Carli
OBJECTIVE: The primary purpose of this experimental study was to compare intubation times for direct laryngoscopy with a Miller blade and for 3 VL: GlideScope® videolaryngoscope, Airtraq®, and McGrath®. METHODS: Seventy-seven operators, with various experience of pediatric tracheal intubation (from none to expert), performed 10 attempts of orotracheal intubation with each device on an infant manikin. The main outcome was intubation time and secondary outcome was failure rate...
December 2013: Annales Françaises D'anesthèsie et de Rèanimation
Laura Miller, Lola Arakaki, Arianne Ramautar, Sara Bodach, Sarah L Braunstein, Joseph Kennedy, Linda Steiner-Sichel, Stephanie Ngai, Colin Shepard, Don Weiss
BACKGROUND: An association between HIV and invasive meningococcal disease (IMD) has been suggested by several previous studies but has not been fully described in the era of highly active antiretroviral therapy in the United States. OBJECTIVE: To estimate the risk for IMD and death in people living with HIV/AIDS (PLWHA) in New York City (NYC) and the contribution of CD4(+) cell count and viral load (VL) to IMD risk. DESIGN: Comparison of the incidence rate of IMD among PLWHA with that among HIV-uninfected persons...
January 7, 2014: Annals of Internal Medicine
Pierre Kory, Keith Guevarra, Joseph P Mathew, Abhijith Hegde, Paul H Mayo
BACKGROUND: The video laryngoscope (VL) has been shown to improve laryngoscopic views and first-attempt success rates in elective operating room and simulated tracheal intubations compared with the direct laryngoscope (DL). However, there are limited data on the effectiveness of the VL compared with the DL in urgent endotracheal intubations (UEIs) in the critically ill. We assessed the effectiveness of using a VL as the primary intubating device during UEI in critically ill patients when performed by less experienced operators...
July 2013: Anesthesia and Analgesia
John Miller, Ronald Croce, Michael Horvat, Wayne Smith
Effect of contraction intensity [100%, 75%, 50%, and 25% maximum voluntary contraction (MVC)] and movement velocity [0 degrees (isometric)], 50 degrees, 100 degrees, 200 degrees, and 400 degrees/sec. [isovelocities]) on root mean square amplitude (SEMG-RMS) and median frequency power spectrum (SEMG-MNF) of vastus lateralis (VL) surface electromyography was investigated with ten healthy female university students. Peak torque (PT), mean torque (MT), SEMG-MNF, and SEMG-RMS, analyzed using separate repeated-measures analyses of variance (p < or = ...
June 2012: Perceptual and Motor Skills
Carmel B Stober, Selma M B Jeronimo, Nubia N Pontes, E Nancy Miller, Jenefer M Blackwell
Visceral leishmaniasis (VL) is fatal if untreated, and there are no vaccines for this disease. High levels of CD4-derived interferon-γ (IFN-γ) in the presence of low levels of interleukin-10 (IL-10) predicts vaccine success. Tumor necrosis factor-α (TNF-α) is also important in this process. We characterized human immune responses in three groups exposed to Leishmania infantum chagasi in Brazil: 1) drug-cured VL patients (recovered VL); 2) asymptomatic persons with positive Leishmania-specific delayed-type hypersensitivity skin reactions (DTH+); and 3) DTH-negative household contacts...
October 2012: American Journal of Tropical Medicine and Hygiene
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