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JOURNAL ARTICLE
Tamara Jahmani, Michael R Miller, Orlando da Silva, Soume Bhattacharya
UNLABELLED: Minimally invasive surfactant therapy (MIST) has emerged as a preferred method of surfactant delivery. Pioneers of this technique have described the use of direct laryngoscopy (DL) for MIST. With the increasing application of video laryngoscopy (VL) for neonatal airway management, it is speculated that MIST techniques can be adapted for use with VL. OBJECTIVE: To compare procedural success, operator ease of use, and complication of MIST using VL vs. MIST using DL...
March 9, 2024: Biomedicines
#2
JOURNAL ARTICLE
Alexandra A Abu-Shmais, Rose J Miller, Alexis K Janke, Rachael M Wolters, Clinton M Holt, Nagarajan Raju, Robert H Carnahan, James E Crowe, Jarrod J Mousa, Ivelin S Georgiev
Human parainfluenza virus 3 (HPIV3) is a widespread pathogen causing severe and lethal respiratory illness in at-risk populations. Effective countermeasures are in various stages of development; however, licensed therapeutic and prophylactic options are not available. The fusion glycoprotein (HPIV3 F), responsible for facilitating viral entry into host cells, is a major target of neutralizing Abs that inhibit infection. Although several neutralizing Abs against a small number of HPIV3 F epitopes have been identified to date, relatively little is known about the Ab response to HPIV3 compared with other pathogens, such as influenza virus and SARS-CoV-2...
March 15, 2024: Journal of Immunology
#3
JOURNAL ARTICLE
Gamze Küçükosman, Keziban Bollucuoğlu, Mahmut Ava, Hilal Ayoğlu
Background and Objective : Placing the laryngoscope blade directly under the epiglottis (known as the direct view (DV) method) during videolaryngoscopy offers a superior view of the glottis when compared to the indirect method of lifting the epiglottis by positioning the Macintosh blade tip over the vallecula. While there are few studies comparing glottic views using Miller and Macintosh blades in pediatric patients, we have not come across such a study in adults. In this study, we aimed to compare the effectiveness and hemodynamic responses of the Miller laryngoscope and the McGrath-MAC videolaryngoscope (VL) in visualizing the glottic opening using the DV method...
December 28, 2023: Medicina
#4
JOURNAL ARTICLE
Alex A Olmos, Adam J Sterczala, Mandy E Parra, Hannah L Dimmick, Jonathan D Miller, Jake A Deckert, Stephanie A Sontag, Philip M Gallagher, Andrew C Fry, Trent J Herda, Michael A Trevino
AIMS: Motor unit recruitment and firing rate patterns of the vastus lateralis (VL) have not been compared between sexes during moderate- and high-intensity contraction intensities. Additionally, the influence of fiber composition on potential sex-related differences remains unquantified. METHODS: Eleven males and 11 females performed 40% and 70% maximal voluntary contractions (MVCs). Surface electromyographic (EMG) signals recorded from the VL were decomposed. Recruitment thresholds (RTs), MU action potential amplitudes (MUAPAMP ), initial firing rates (IFRs), mean firing rates (MFRs), and normalized EMG amplitude (N-EMGRMS ) at steady torque were analyzed...
August 8, 2023: Acta Physiologica
#5
JOURNAL ARTICLE
Mitch Matoga, Jane S Chen, Cecilia Massa, Isaac Thengolose, Gerald Tegha, Beatrice Ndalama, Naomi Bonongwe, Esther Mathiya, Edward Jere, Gabriel Banda, Shiraz Khan, Amy J Loftis, Angela Kashuba, Mackenzie L Cottrell, Amanda P Schauer, Brian Van Horne, Lauren A Tompkins, Kathryn E Lancaster, William C Miller, Joseph E Eron, Irving F Hoffman, Myron S Cohen
OBJECTIVES: To examine the time required to suppress HIV in the genital tract with antiretroviral therapy (ART) in men with urethritis. DESIGN: An observational cohort study. METHODS: Men with HIV and urethritis not on ART were enrolled at an STI clinic in Malawi and offered to initiate ART. Blood and semen samples were collected pre-treatment and at 1, 2, 4, 8, 12 and 24 weeks post-urethritis treatment. Median viral loads (VL) were calculated by ART initiation groups: 'within 1 week', 'between 1-4 weeks' and 'no ART before 4 weeks', based on the men's choice about whether or not to initiate ART...
August 3, 2023: AIDS
#6
JOURNAL ARTICLE
Alex A Olmos, Stephanie A Sontag, Adam J Sterczala, Mandy E Parra, Hannah L Dimmick, Jonathan D Miller, Jake A Deckert, Trent J Herda, Michael A Trevino
Purpose : To examine the effects of a 5-week continuous cycling training intervention on electromyographic amplitude (EMGRMS )- and mechanomyographic amplitude (MMGRMS )-torque relationships of the vastus lateralis (VL) during a prolonged contraction. Methods : Twenty-four sedentary, young adults performed maximal voluntary contractions (MVCs) and a prolonged isometric trapezoidal contraction at the same absolute 40% MVC for the knee extensors before (PRE) and after training (POSTABS ). Individual b - (slopes) and a -terms (y-intercepts) were calculated from the log-transformed electromyographic amplitude (EMGRMS )- and mechanomyographic amplitude (MMGRMS )-torque relationships during the increasing and decreasing segments of the trapezoid...
June 27, 2023: Research Quarterly for Exercise and Sport
#7
JOURNAL ARTICLE
Samriti Manhas, Nidhi Agrawal, Swati Jain, Ridhima Sharma, Ripon Choudhary
BACKGROUND AND AIMS: Endotracheal intubation (ET) in infants is considered a challenging task over the decades. Infants have short safe apnoea time, and this difficulty has been vanquished to some extent by using the videolaryngoscopes (VLs), but there exists a dearth of research particularly in this vulnerable subset. Therefore, this trial was conducted to evaluate intubation times obtained with C-MAC VL and conventional Miller laryngoscopes in infants. METHODS: A total of 80 infants aged between 1 month and 1 year with American Society of Anesthesiologists physical status I-II requiring ET were randomised in two groups; the C-MAC VL or Miller laryngoscope ML...
February 2023: Indian Journal of Anaesthesia
#8
JOURNAL ARTICLE
Stephanie A Sontag, Adam J Sterczala, Jonathan D Miller, Jake A Deckert, Alex A Olmos, Mandy E Parra, Hannah L Dimmick, Philip M Gallagher, Andrew C Fry, Trent J Herda, Michael A Trevino
This study examined relationships between percent myosin heavy chain (%MHC) expression and mechanomyographic amplitude (MMGRMS ). Fifteen females (age ± SD=21.3 ± 5.3 yrs) completed isometric trapezoidal contractions at 30% and 70% maximal voluntary contraction (MVC). MMG was recorded from the vastus lateralis (VL). Participants gave a muscle biopsy of the VL post-testing. MMGRMS -torque relationships during the linearly varying segments were log-transformed and linear regressions were applied to calculate b terms (slopes)...
January 2023: Medical Engineering & Physics
#9
JOURNAL ARTICLE
Matthew Miller, Heather Storey, Jeffrey Andrew, Edward Christian, Clare Hayes-Bradley
OBJECTIVES: After introducing an adult video laryngoscope (VL) in our physician-paramedic prehospital and retrieval medical service, our quality assurance process identified this blade being used during pediatric intubations. We present a case series of pediatric intubations using this oversized adult VL alongside a contemporaneous group of direct laryngoscopy (DL) intubations. METHODS: We performed a retrospective review of intubated patients 15 years or younger in our electronic quality assurance registry from January 1, 2017, to December 31, 2020...
February 16, 2023: Pediatric Emergency Care
#10
JOURNAL ARTICLE
Sachin Goel, Ripon Choudhary, Rohan Magoon, Ridhima Sharma, G Usha, Poonam M Kapoor, Deepak Bagga
BACKGROUND AND AIMS: An efficient neonatal airway management is peculiarly challenging even in the most experienced hands. Considering the recent interest in assessing the performance of various video-laryngoscopes (VL) in pediatric cohort, the prospective randomized study was contemplated to stage a comparative evaluation of C-MAC with Miller laryngoscope for neonatal endotracheal intubation. MATERIAL AND METHODS: 150 neonates were randomized to undergo intubation with either the C-MAC VL ( n = 75) or the Miller laryngoscope ( n = 75) performed by an experienced anesthesiologist in a tertiary care perioperative setting...
2022: Journal of Anaesthesiology, Clinical Pharmacology
#11
JOURNAL ARTICLE
Isabel A Ely, Eleanor J Jones, Thomas B Inns, Síobhra Dooley, Sarah B J Miller, Daniel W Stashuk, Philip J Atherton, Bethan E Phillips, Mathew Piasecki
NEW FINDINGS: What is the central question of this study? Can bilateral knee extensor force accuracy be improved following 4 weeks of unilateral force accuracy training and are there any subsequent alterations to central and/or peripheral motor unit features? What is the main finding and its importance? In the trained limb only, knee extensor force tracking accuracy improved with reduced motor unit firing rate variability in the vastus lateralis, and there was no change to neuromuscular junction transmission instability...
September 2022: Experimental Physiology
#12
JOURNAL ARTICLE
Garrett S Pacheco, Aaron N Leetch, Asad E Patanwala, Nicholas B Hurst, Jenny S Mendelson, John C Sakles
BACKGROUND: Pediatric emergency intubation is a high-acuity, low-occurrence procedure. Despite advances in technology, the success of this procedure remains low and adverse events are very high. Prospective observational studies in children have demonstrated improved success with the use of video laryngoscopy (VL) compared with direct laryngoscopy, although reported first-pass success (FPS) rates are lower than that reported for adults. This may in part be due to difficulty directing the tracheal tube to the laryngeal inlet considering the cephalad position of the larynx in infants...
July 16, 2022: Pediatric Emergency Care
#13
JOURNAL ARTICLE
Michael A Trevino, Hannah L Dimmick, Mandy E Parra, Adam J Sterczala, Jonathan D Miller, Jake A Deckert, Philip M Gallagher, Andrew C Fry, Joseph P Weir, Trent J Herda
This study examined the effects of continuous endurance training on motor unit (MU) mean firing rates (MFR), percent myosin heavy chain (%MHC) isoforms, and muscle cross-sectional area (mCSA) of the vastus lateralis (VL). Twelve females completed 5-weeks of continuous cycling-training (CYC), while 8 females were controls (CON). Participants performed maximal voluntary contractions (MVCs) and 40% MVCs of the knee extensors before (PRE) and after the 5-week treatment period at the same absolute pre-treatment submaximal torque (POSTABS ) and relative to post-treatment MVCs (POSTREL )...
March 2022: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
#14
JOURNAL ARTICLE
Jane S Chen, Audrey E Pettifor, Julie Ae Nelson, Sam Phiri, Dana K Pasquale, Wiza Kumwenda, Gift Kamanga, Mackenzie L Cottrell, Craig Sykes, Angela Dm Kashuba, Gerald Tegha, Robert Krysiak, Isaac Thengolose, Myron S Cohen, Irving F Hoffman, William C Miller, Sarah E Rutstein
BACKGROUND: Persons with acute HIV infection (AHI) are highly infectious and responsible for a disproportionate share of incident infections. Immediate antiretroviral therapy (ART) rapidly reduces blood viral loads (VL), but genital VLs after ART initiation during AHI are less well described. SETTING: Lilongwe, Malawi, 2012-2014. METHODS: HIV-seronegative and -serodiscordant persons ≥18 years were screened for AHI (RNA positive), and randomized to standard care, behavioral intervention, or behavioral intervention plus short-term ART (raltegravir/emtricitabine/tenofovir) (1:2:2)...
January 17, 2022: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#15
JOURNAL ARTICLE
Matthew R Miller, Hugo Gemal, Sandra Ware, Clare Hayes-Bradley
BACKGROUND: During videolaryngoscopy (VL), the larynx appears within the defined area of the video screen, and its location can be measured as a point within this space. Spatial statistics offer methods to explore the relationship between location data and associated variables of interest. The aims of this study were to use spatial point pattern analysis to explore if the position of the larynx on VL is associated with longer times to intubate, increased risk of a needing >1 intubation attempt, or percentage of glottic opening...
June 1, 2022: Anesthesia and Analgesia
#16
JOURNAL ARTICLE
Shema Tariq, Hajra Okhai, Abigail Severn, Caroline A Sabin, Fiona Burns, Richard Gilson, Julie Fox, Yvonne Gilleece, Nicola E Mackie, Frank A Post, Iain Reeves, Melanie Rosenvinge, Ann Sullivan, Andrew Ustianowski, Robert F Miller
OBJECTIVES: We examined follicle-stimulating hormone (FSH) levels in women living with HIV aged > 45 reporting ≥ 12 months' amenorrhoea, and investigated correlation with menopausal symptoms. METHODS: A cross-sectional substudy of 85 women from the Positive Transitions through the Menopause (PRIME) Study who reported irregular periods at entry into the PRIME Study and ≥ 12 months' amenorrhoea at recruitment into this substudy. Serum FSH was supplemented with clinical data and menopausal symptom assessment...
April 2022: HIV Medicine
#17
JOURNAL ARTICLE
William A Werbel, Diane M Brown, Oyinkansola T Kusemiju, Brianna L Doby, Shanti M Seaman, Andrew D Redd, Yolanda Eby, Reinaldo E Fernandez, Niraj M Desai, Jernelle Miller, Gilad A Bismut, Charles S Kirby, Haley A Schmidt, William A Clarke, Michael Seisa, Christos J Petropoulos, Thomas C Quinn, Sander S Florman, Shirish Huprikar, Meenakshi M Rana, Rachel J Friedman-Moraco, Aneesh K Mehta, Peter G Stock, Jennifer C Price, Valentina Stosor, Shikha G Mehta, Alexander J Gilbert, Nahel Elias, Michele I Morris, Sapna A Mehta, Catherine B Small, Ghady Haidar, Maricar Malinis, Jennifer S Husson, Marcus R Pereira, Gaurav Gupta, Jonathan Hand, Varvara A Kirchner, Avinash Agarwal, Saima Aslam, Emily A Blumberg, Cameron R Wolfe, Kevin Myer, R Patrick Wood, Nikole Neidlinger, Sara Strell, Marion Shuck, Harry Wilkins, Matthew Wadsworth, Jennifer D Motter, Jonah Odim, Dorry L Segev, Christine M Durand, Aaron A R Tobian
BACKGROUND: Organ transplantation from donors with HIV to recipients with HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics of HIV+ donors is critical for safety. METHODS: We performed a prospective study of donors with HIV-positive and HIV false-positive (FP) testing within the HOPE in Action studies of HIV D+/R+ transplantation (ClinicalTrials.gov NCT02602262; NCT03500315; NCT03734393)...
August 28, 2021: Clinical Infectious Diseases
#18
JOURNAL ARTICLE
Refeletswe Lebelonyane, Pamela Bachanas, Lisa Block, Faith Ussery, Mary Grace Alwano, Tafireyi Marukutira, Shenaaz El Halabi, Michelle Roland, William Abrams, Gene Ussery, James A Miller, Shahin Lockman, Tendani Gaolathe, Molly Pretorius Holme, Shannon Hader, Lisa A Mills, Kathleen Wirth, Naomi Bock, Janet Moore
BACKGROUND: Increasing HIV treatment coverage is crucial to reducing population-level HIV incidence. METHODS: The Botswana Combination Prevention Project (BCPP) was a community randomized trial examining the impact of multiple prevention interventions on population-level HIV incidence and was conducted from October 2013 through June 2017. Home and mobile campaigns offered HIV testing to all individuals ≥ age 16. All identified HIV-positive persons who were not on antiretroviral therapy (ART) were referred to treatment and tracked to determine linkage to care, ART status, retention in treatment, and viral suppression...
2021: PloS One
#19
JOURNAL ARTICLE
Andreas Moritz, Luise Holzhauser, Tobias Fuchte, Sven Kremer, Joachim Schmidt, Andrea Irouschek
BACKGROUND: Video laryngoscopy is an effective tool in the management of difficult pediatric airway. However, evidence to guide the choice of the most appropriate video laryngoscope (VL) for airway management in pediatric patients with Pierre Robin syndrome (PRS) is insufficient. Therefore, the aim of this study was to compare the efficacy of the Glidescope® Core™ with a hyperangulated blade, the C-MAC® with a nonangulated Miller blade (C-MAC® Miller) and a conventional Miller laryngoscope when used by anesthetists with limited and extensive experience in simulated Pierre Robin sequence...
2021: PloS One
#20
JOURNAL ARTICLE
Stephanie A Sontag, Michael A Trevino, Trent J Herda, Adam J Sterczala, Jonathan D Miller, Mandy E Parra, Hannah L Dimmick, Jake Deckert
PURPOSE: To examine the effects of 10 weeks of endurance cycling training on mechanomyographic amplitude (MMGRMS )-torque relationships and muscle cross-sectional area (mCSA) of the vastus lateralis (VL) for 10 sedentary males (Age ± SD; 20.2 ± 1.9 years) and 14 sedentary females (21.9 ± 5.3 years). METHODS: Participants performed maximal voluntary contractions (MVCs) and an isometric ramp up muscle action to 70% MVC of the knee extensors before (PRE) and after training at the same absolute pre-treatment submaximal torque (POSTABS )...
February 18, 2021: European Journal of Applied Physiology
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