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Virginia Miller

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https://www.readbyqxmd.com/read/29661902/brain-structure-and-cognition-3-years-after-the-end-of-an-early-menopausal-hormone-therapy-trial
#1
Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Samantha M Zuk, Val J Lowe, Julie A Fields, Jeffrey L Gunter, Matthew L Senjem, Megan L Settell, Carey E Gleason, Lynne T Shuster, Kent R Bailey, N Maritza Dowling, Sanjay Asthana, Clifford R Jack, Walter A Rocca, Virginia M Miller
OBJECTIVE: The effects of 2 frequently used formulations of menopausal hormone therapy (mHT) on brain structure and cognition were investigated 3 years after the end of a randomized, placebo-controlled trial in recently menopausal women with good cardiovascular health. METHODS: Participants (aged 42-56 years; 5-36 months past menopause) were randomized to one of the following: 0.45 mg/d oral conjugated equine estrogen (oCEE); 50 μg/d transdermal 17β-estradiol (tE2); or placebo pills and patch for 4 years...
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29652419/tricuspid-valve-regurgitation-still-struggling-with-the-who-and-when
#2
Megha Prasad, Pranav Chandrasekar, Virginia Miller, Yogesh N V Reddy
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29608647/bart-a-transcription-factor-prediction-tool-with-query-gene-sets-or-epigenomic-profiles
#3
Zhenjia Wang, Mete Civelek, Clint L Miller, Nathan C Sheffield, Michael J Guertin, Chongzhi Zang
Summary: Identification of functional transcription factors that regulate a given gene set is an important problem in gene regulation studies. Conventional approaches for identifying transcription factors, such as DNA sequence motif analysis, are unable to predict functional binding of specific factors and not sensitive to detect factors binding at distal enhancers. Here we present Binding Analysis for Regulation of Transcription (BART), a novel computational method and software package for predicting functional transcription factors that regulate a query gene set or associate with a query genomic profile, based on more than 6,000 existing ChIP-seq datasets for over 400 factors in human or mouse...
March 28, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29554591/prevalence-of-gabapentin-in-drug-overdose-postmortem-toxicology-testing-results
#4
Svetla Slavova, Alison Miller, Terry L Bunn, Jessica R White, David Kirschke, Tom Light, Daniel Christy, Gary Thompson, Ruth Winecker
BACKGROUND: The goal of this study was to establish and compare baseline data on the prevalence of gabapentin identified through postmortem toxicology testing among drug overdose decedents in several geographically diverse states/jurisdictions with differing levels of drug overdose fatality burdens in 2015. METHODS: Death certificates and postmortem toxicology result reports from five U.S. jurisdictions were used to identify residents who died from drug overdoses in year 2015 and to calculate prevalence rates of gabapentin in postmortem toxicology by jurisdiction...
March 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29463850/microglia-mediated-recovery-from-als-relevant-motor-neuron-degeneration-in-a-mouse-model-of-tdp-43-proteinopathy
#5
Krista J Spiller, Clark R Restrepo, Tahiyana Khan, Myrna A Dominique, Terry C Fang, Rebecca G Canter, Christopher J Roberts, Kelly R Miller, Richard M Ransohoff, John Q Trojanowski, Virginia M-Y Lee
Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. However, only subtle microglial changes were detected during disease in the spinal cord, despite progressive motor neuron loss; microglia still reacted to inflammatory triggers in these mice. Notably, after hTDP-43 expression was suppressed, microglia dramatically proliferated and changed their morphology and gene expression profiles...
February 20, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#6
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29381665/what-s-in-a-name-are-menopausal-hot-flashes-a-symptom-of-menopause-or-a-manifestation-of-neurovascular-dysregulation
#7
Virginia M Miller, Juliana M Kling, Julia A Files, Michael J Joyner, Ekta Kapoor, Ann M Moyer, Walter A Rocca, Stephanie S Faubion
Hot flashes have typically been classified as "symptoms of menopause" that should be tolerated or treated until they resolve. However, mounting evidence points to hot flashes as a manifestation of one or several underlying pathophysiological processes. Associations exist between the presence, timing of onset, severity, and duration of hot flashes, and the risk of several neurological (affecting sleep, mood, and cognition) and cardiovascular conditions. In addition, four consistent patterns of vasomotor disturbances have been identified across different countries, making it unlikely that these patterns are solely explained by socioeconomic or cultural factors...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29344380/sex-stratified-analysis-of-national-trends-and-outcomes-in-isolated-tricuspid-valve-surgery
#8
Pranav Chandrashekar, Erin Amanda Fender, Chad J Zack, Yogesh N V Reddy, Courtney E Bennett, Megha Prasad, Mohammed A Al-Hijji, John M Stulak, Virginia M Miller
Objective: Female sex is a known risk factor for cardiac surgery, and tricuspid valve (TV) disease is more common in women. There are few data on sex-stratified surgical outcomes for isolated TV surgery. An administrative database was used to compare acute in-hospital outcomes between men and women undergoing isolated TV surgery. Methods: Patients aged >18 who underwent TV repair or replacement from 2004 to 2013 were identified using the National Inpatient Sample...
2018: Open Heart
https://www.readbyqxmd.com/read/29241483/national-trends-and-outcomes-in-isolated-tricuspid-valve-surgery
#9
MULTICENTER STUDY
Chad J Zack, Erin A Fender, Pranav Chandrashekar, Yogesh N V Reddy, Courtney E Bennett, John M Stulak, Virginia M Miller, Rick A Nishimura
BACKGROUND: Severe isolated disease of the tricuspid valve (TV) is increasing and results in intractable right heart failure. However, isolated TV surgery is rarely performed, and there are little data describing surgical outcomes. OBJECTIVES: The purpose of this study was to evaluate contemporary utilization trends and in-hospital outcomes for isolated TV surgery in the United States. METHODS: Patients age >18 years who underwent TV repair or replacement from 2004 to 2013 were identified using the National Inpatient Sample...
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29232982/antioxidant-and-antimicrobial-properties-of-casteanea-sativa-miller-chestnut-honey-produced-on-mount-etna-sicily
#10
Simone Ronsisvalle, Edmondo Lissandrello, Virginia Fuochi, Giulio Petronio Petronio, Claudia Straquadanio, Lucia Crascì, Annamaria Panico, Marcella Milito, Anna Maria Cova, Gianna Tempera, Pio Maria Furneri
The aim of this study was the evaluation of antibacterial and antioxidant properties of Monofloral Etna Castanea sativa Miller honeys. Escherichia coli ATCC 25,922, Pseudomonas aeruginosa ATCC 27,853, Enterococcus faecalis ATCC 29,211 and Staphylococcus aureus ATCC 29,213 were investigated for their susceptibilities to two different honeys. Antioxidant activity was evaluated by ORAC, NO scavenger assays, FRAP and DPPH. Antioxidant activity and antibacterial properties were compared with chestnut honeys from different geographical areas and with Manuka honey...
December 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29208690/aortic-hemodynamics-in-postmenopausal-women-following-cessation-of-hormone-therapy
#11
Ronée E Harvey, Maja C Johnson, Sushant M Ranadive, Michael J Joyner, Brian D Lahr, Virginia M Miller, Jill N Barnes
Central (aortic) blood pressure and aortic pulse wave characteristics are measures of cardiovascular health, predictive of cardiovascular mortality. Previous studies have compared aortic hemodynamics in women who do and do not take menopausal hormone therapy, but characteristics of these parameters following cessation of treatment have not been defined. Therefore, the purpose of this study was to define aortic pulse wave characteristics in postmenopausal women with and without a history of menopausal hormone therapy use...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29185154/counseling-on-access-to-lethal-means-calm-an-evaluation-of-a-suicide-prevention-means-restriction-training-program-for-mental-health-providers
#12
Elizabeth Sale, Michelle Hendricks, Virginia Weil, Collin Miller, Scott Perkins, Suzanne McCudden
This paper evaluates the effectiveness of the Counseling on Access to Lethal Means (CALM) suicide prevention program. CALM trains mental health providers how to counsel suicidal individuals and those who support them on mean restriction during times of crisis. Pre/post/3-month follow-up assessments measured knowledge of lethal means, confidence and comfort in discussing means restriction (self-efficacy), and future intentions to counsel clients on means restriction. Change in the number of clients receiving lethal means counseling was also assessed...
November 28, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29171432/locomotor-analysis-identifies-early-compensatory-changes-during-disease-progression-and-subgroup-classification-in-a-mouse-model-of-amyotrophic-lateral-sclerosis
#13
Melissa M Haulcomb, Rena M Meadows, Whitney M Miller, Kathryn P McMillan, MeKenzie J Hilsmeyer, Xuefu Wang, Wesley T Beaulieu, Stephanie L Dickinson, Todd J Brown, Virginia M Sanders, Kathryn J Jones
Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival. Early identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease progression. Use of the mSOD1G93A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients, while investigating underlying disease-induced changes...
October 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29169579/data-registry-on-experiences-of-aging-menopause-and-sexuality-dreams-a-cohort-profile
#14
REVIEW
Stephanie S Faubion, Ekta Kapoor, Juliana M Kling, Carol L Kuhle, Richa Sood, Jordan E Rullo, Jacqueline M Thielen, Lynne T Shuster, Walter A Rocca, Karla S Frohmader Hilsaca, Kristin C Mara, Darrell R Schroeder, Virginia M Miller
The Women's Health Clinic (WHC) at Mayo Clinic in Rochester, Minnesota, has provided consultative care to women with menopausal and sexual health concerns since 2005. Clinical information on the 8688 women seen in the WHC through May 2017 who gave consent for the use of their medical records in research is contained in the Data Registry on Experiences of Aging, Menopause, and Sexuality (DREAMS). Initially, DREAMS was created to improve the clinical care of women, but it has become a valuable research tool. About 25% of the DREAMS women have been seen in the WHC 2 or more times, allowing for passive longitudinal follow-up...
January 2018: Maturitas
https://www.readbyqxmd.com/read/29162577/cohort-profile-the-mayo-clinic-cohort-study-of-oophorectomy-and-aging-2-moa-2-in-olmsted-county-minnesota-usa
#15
Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, Elizabeth A Stewart, Michelle M Mielke, Kejal Kantarci, Virginia M Miller
PURPOSE: This cohort study was established to investigate the effects of unilateral and bilateral oophorectomy on the ageing processes in women. PARTICIPANTS: We used the records-linkage system of the Rochester Epidemiology Project (REP, http://www.rochesterproject.org) to identify 570 women who underwent unilateral oophorectomy and 1653 women who underwent bilateral oophorectomy in Olmsted County, Minnesota from 1988 through 2007 (20 years). Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone any oophorectomy (570 referent women) or bilateral oophorectomy (1653 referent women)...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29158356/cerebrovascular-reactivity-and-vascular-activation-in-postmenopausal-women-with-histories-of-preeclampsia
#16
Jill N Barnes, Ronée E Harvey, Kathleen B Miller, Muthuvel Jayachandran, Katherine R Malterer, Brian D Lahr, Kent R Bailey, Michael J Joyner, Virginia M Miller
Cerebrovascular reactivity (CVR) is reduced in patients with cognitive decline. Women with a history of preeclampsia are at increased risk for cognitive decline. This study examined an association between pregnancy history and CVR using a subgroup of 40 age- and parity-matched pairs of women having histories of preeclampsia (n=27) or normotensive pregnancy (n=29) and the association of activated blood elements with CVR. Middle cerebral artery velocity was measured by Doppler ultrasound before and during hypercapnia to assess CVR...
November 20, 2017: Hypertension
https://www.readbyqxmd.com/read/29126824/video-intervention-to-increase-perceived-self-efficacy-for-condom-use-in-a-randomized-controlled-trial-of-female-adolescents
#17
Julie S Downs, Amie M Ashcraft, Pamela J Murray, Elise D Berlan, Wändi Bruine de Bruin, Joan Eichner, Baruch Fischhoff, Janie M Leary, Robert B McCall, Elizabeth Miller, Jennifer Salaway, Janell Smith-Jones, Gina S Sucato
STUDY OBJECTIVE: To assess the effects of the Seventeen Days interactive video on young women's perceived self-efficacy for using condoms 6 months after being offered the intervention, relative to a control. DESIGN: Multisite randomized controlled trial. SETTING: Twenty participating health clinics and county health departments in Ohio, Pennsylvania, and West Virginia. PARTICIPANTS: Sexually active female adolescents ages 14 to 19 years...
November 7, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29120834/cervical-cancer-screening-in-the-national-breast-and-cervical-cancer-early-detection-program-nbccedp-in-four-us-affiliated-pacific-islands-between-2007-and-2015
#18
Virginia Senkomago, Janet Royalty, Jacqueline W Miller, Lee E Buenconsejo-Lum, Vicki B Benard, Mona Saraiya
BACKGROUND: Cervical cancer incidence in the US-Affiliated Pacific Islands (USAPIs) is double that of the US mainland. American Samoa, Commonwealth of Northern Mariana Islands (CNMI), Guam and the Republic of Palau receive funding from the Centers for Disease Control (CDC) National Breast and Cervical Cancer Early Detection Program (NBCCEDP) to implement cervical cancer screening to low-income, uninsured or under insured women. The USAPI grantees report data on screening and follow-up activities to the CDC...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29089874/mistakes-too-few-to-mention-impaired-self-conscious-emotional-processing-of-errors-in-the-behavioral-variant-of-frontotemporal-dementia
#19
Carole S Scherling, Jessica Zakrzewski, Samir Datta, Robert W Levenson, Arthur P Shimamura, Virginia E Sturm, Bruce L Miller, Howard J Rosen
Anosognosia, or lack of awareness of one's deficits, is a core feature of the behavioral variant of frontotemporal dementia (bvFTD). We hypothesized that this deficit has its origins in failed emotional processing of errors. We studied autonomic and facial emotional reactivity to errors in patients with bvFTD ( n = 17), Alzheimer's disease (AD, n = 20), and healthy controls (HC, n = 35) during performance of a timed two-alternative-choice button press task. Performance-related behavioral responses to errors were quantified using rates of error correction and post-error slowing of reaction times...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29075567/prosocial-deficits-in-behavioral-variant-frontotemporal-dementia-relate-to-reward-network-atrophy
#20
Virginia E Sturm, David C Perry, Kristie Wood, Alice Y Hua, Oscar Alcantar, Samir Datta, Katherine P Rankin, Howard J Rosen, Bruce L Miller, Joel H Kramer
INTRODUCTION: Empathy and shared feelings of reward motivate individuals to share resources with others when material gain is not at stake. Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disease that affects emotion- and reward-relevant neural systems. Although there is diminished empathy and altered reward processing in bvFTD, how the disease impacts prosocial behavior is less well understood. METHODS: A total of 74 participants (20 bvFTD, 15 Alzheimer's disease [AD], and 39 healthy controls) participated in this study...
October 2017: Brain and Behavior
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