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Virginia Miller

Karina Banda-R, Alfonso Delgado-Salinas, Kyle G Dexter, Reynaldo Linares-Palomino, Ary Oliveira-Filho, Darién Prado, Martin Pullan, Catalina Quintana, Ricarda Riina, Gina M Rodríguez M, Julia Weintritt, Pedro Acevedo-Rodríguez, Juan Adarve, Esteban Álvarez, Anairamiz Aranguren B, Julián Camilo Arteaga, Gerardo Aymard, Alejandro Castaño, Natalia Ceballos-Mago, Álvaro Cogollo, Hermes Cuadros, Freddy Delgado, Wilson Devia, Hilda Dueñas, Laurie Fajardo, Ángel Fernández, Miller Ángel Fernández, Janet Franklin, Ethan H Freid, Luciano A Galetti, Reina Gonto, Roy González-M, Roger Graveson, Eileen H Helmer, Álvaro Idárraga, René López, Humfredo Marcano-Vega, Olga G Martínez, Hernán M Maturo, Morag McDonald, Kurt McLaren, Omar Melo, Francisco Mijares, Virginia Mogni, Diego Molina, Natalia Del Pilar Moreno, Jafet M Nassar, Danilo M Neves, Luis J Oakley, Michael Oatham, Alma Rosa Olvera-Luna, Flávia F Pezzini, Orlando Joel Reyes Dominguez, María Elvira Ríos, Orlando Rivera, Nelly Rodríguez, Alicia Rojas, Tiina Särkinen, Roberto Sánchez, Melvin Smith, Carlos Vargas, Boris Villanueva, R Toby Pennington
Seasonally dry tropical forests are distributed across Latin America and the Caribbean and are highly threatened, with less than 10% of their original extent remaining in many countries. Using 835 inventories covering 4660 species of woody plants, we show marked floristic turnover among inventories and regions, which may be higher than in other neotropical biomes, such as savanna. Such high floristic turnover indicates that numerous conservation areas across many countries will be needed to protect the full diversity of tropical dry forests...
September 23, 2016: Science
Andrea G Kattah, Dawn C Scantlebury, Sanket Agarwal, Michelle M Mielke, Walter A Rocca, Amy L Weaver, Lisa E Vaughan, Virginia M Miller, Tracey L Weissgerber, Wendy White, Vesna D Garovic
BACKGROUND: Several registry-based studies, using diagnostic codes, have suggested that preeclampsia is a risk factor for end-stage renal disease (ESRD). However, because the 2 diseases share risk factors, the true nature of their association remains uncertain. Our goals were to conduct a population-based study to determine the magnitude of the association between preeclampsia and ESRD and evaluate the role of shared risk factors. STUDY DESIGN: Population-based nested case-control study...
October 1, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Maxime Bertoux, Marie Sarazin, Florence Pasquier, Michel Bottlaender, Leonardo Cruz de Souza, Eneida Mioshi, Michael Hornberger, Kamalini G Ranasinghe, Katherine P Rankin, Iryna V Lobach, Joel H Kramer, Virginia E Sturm, Brianne M Bettcher, Katherine Possin, S Christine You, Amanda K Lamarre, Tal Shany-Ur, Melanie L Stephens, David C Perry, Suzee E Lee, Zachary A Miller, Maria L Gorno-Tempini, Howard J Rosen, Adam Boxer, William W Seeley, Gil D Rabinovici, Keith A Vossel, Bruce L Miller
No abstract text is available yet for this article.
October 4, 2016: Neurology
Walter A Rocca, Liliana Gazzuola-Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, James L Kirkland, Elizabeth A Stewart, Virginia M Miller
OBJECTIVE: To study the association between bilateral oophorectomy and the rate of accumulation of multimorbidity. PATIENTS AND METHODS: In this historical cohort study, the Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy before age 50 years between January 1, 1988, and December 31, 2007, in Olmsted County, Minnesota. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy...
September 28, 2016: Mayo Clinic Proceedings
Leah R Miller, Cheryl Marks, Jill B Becker, Patricia D Hurn, Wei-Jung Chen, Teresa Woodruff, Margaret M McCarthy, Farida Sohrabji, Londa Schiebinger, Cora Lee Wetherington, Susan Makris, Arthur P Arnold, Gillian Einstein, Virginia M Miller, Kathryn Sandberg, Susan Maier, Terri L Cornelison, Janine A Clayton
In June 2015, the National Institutes of Health (NIH) released a Guide notice (NOT-OD-15-102) that highlighted the expectation of the NIH that the possible role of sex as a biologic variable be factored into research design, analyses, and reporting of vertebrate animal and human studies. Anticipating these guidelines, the NIH Office of Research on Women's Health, in October 2014, convened key stakeholders to discuss methods and techniques for integrating sex as a biologic variable in preclinical research. The workshop focused on practical methods, experimental design, and approaches to statistical analyses in the use of both male and female animals, cells, and tissues in preclinical research...
September 28, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Suellen Miller, Edgardo Abalos, Monica Chamillard, Agustin Ciapponi, Daniela Colaci, Daniel Comandé, Virginia Diaz, Stacie Geller, Claudia Hanson, Ana Langer, Victoria Manuelli, Kathryn Millar, Imran Morhason-Bello, Cynthia Pileggi Castro, Vicky Nogueira Pileggi, Nuriya Robinson, Michelle Skaer, João Paulo Souza, Joshua P Vogel, Fernando Althabe
On the continuum of maternal health care, two extreme situations exist: too little, too late (TLTL) and too much, too soon (TMTS). TLTL describes care with inadequate resources, below evidence-based standards, or care withheld or unavailable until too late to help. TLTL is an underlying problem associated with high maternal mortality and morbidity. TMTS describes the routine over-medicalisation of normal pregnancy and birth. TMTS includes unnecessary use of non-evidence-based interventions, as well as use of interventions that can be life saving when used appropriately, but harmful when applied routinely or overused...
September 14, 2016: Lancet
Virginia M Miller, Vesna D Garovic, Kent R Bailey, Brian D Lahr, Michelle M Mielke, Wendy M White, Muthuvel Jayachandran
BACKGROUND AND AIMS: Having a history of preeclampsia increases the risk for future coronary artery calcification (CAC). This study evaluated the association of blood-borne, cell-derived microvesicles (MV) with CAC in middle-aged women. METHODS: Twelve pre-selected, antigen-specific MV were measured by digital flow cytometry in the blood of age- and parity-matched women (median age 60 years) without a history of cardiovascular events, but with either a history of preeclampsia (PE, n = 39) or normotensive pregnancy (NP, n = 40)...
October 2016: Atherosclerosis
Francesco Vetrini, Lisa C A D'Alessandro, Zeynep C Akdemir, Alicia Braxton, Mahshid S Azamian, Mohammad K Eldomery, Kathryn Miller, Chelsea Kois, Virginia Sack, Natasha Shur, Asha Rijhsinghani, Jignesh Chandarana, Yan Ding, Judy Holtzman, Shalini N Jhangiani, Donna M Muzny, Richard A Gibbs, Christine M Eng, Neil A Hanchard, Tamar Harel, Jill A Rosenfeld, John W Belmont, James R Lupski, Yaping Yang
Disruption of the establishment of left-right (L-R) asymmetry leads to situs anomalies ranging from situs inversus totalis (SIT) to situs ambiguus (heterotaxy). The genetic causes of laterality defects in humans are highly heterogeneous. Via whole-exome sequencing (WES), we identified homozygous mutations in PKD1L1 from three affected individuals in two unrelated families. PKD1L1 encodes a polycystin-1-like protein and its loss of function is known to cause laterality defects in mouse and medaka fish models...
October 6, 2016: American Journal of Human Genetics
Melissa K Miller, Ju Jiang, Melissa Truong, Tamasin Yarina, Holly Evans, Timothy P Christensen, Allen L Richards
Four species of ticks known to parasitize humans (Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Amblyomma maculatum (Gulf Coast tick), and Ixodes scapularis (black-legged tick)) were collected at Joint Base Langley-Eustis, Fort Eustis, Virginia during 2009. These ticks were tested individually (adults and nymphs) and in pools of 15 (larvae) for pathogens of public health importance within the genera: Rickettsia, Borrelia, and Ehrlichia, by quantitative real-time polymerase chain reaction (qPCR) assays and, where appropriate, multilocus sequence typing (MLST)...
October 2016: U.S. Army Medical Department Journal
Peter S Pressman, Yuliana Noniyeva, Nick Bott, Shubir Dutt, Virginia Sturm, Bruce L Miller, Joel H Kramer
Many emotional functions are relatively preserved in aging despite declines in several cognitive domains and physical health. High levels of happiness exist even among centenarians. To address the hypothesis of whether preservation of emotional function in healthy aging may relate to different rates of age-related volume loss across brain structures, we performed two volumetric analyses on structural magnetic resonance neuroimaging of a group of healthy aging research participants using Freesurfer version 5...
2016: PloS One
Kathryn Polak, Pamela Dillon, J Randy Koch, Willis G Miller, Leroy Thacker, Dace Svikis
The increasing prevalence of energy drink (ED) use and its link with negative behaviors and adverse health outcomes has garnered much attention. Use of EDs combined with alcohol among college students has been of particular interest. It is unclear if these relationships develop in the context of college, or if similar associations exist in younger individuals. The present study examined associations between ED consumption patterns and other substance use in an adolescent, school-based sample. Participants were N = 3743 students attending 8th, 10th or 12th grade in a suburban central Virginia public school system who completed a prevention needs assessment survey in 2012...
December 2016: Preventive Medicine Reports
Janice M Leung, Virginia Chen, Zsuzsanna Hollander, Darlene Dai, Scott J Tebbutt, Shawn D Aaron, Kathy L Vandemheen, Stephen I Rennard, J Mark FitzGerald, Prescott G Woodruff, Stephen C Lazarus, John E Connett, Harvey O Coxson, Bruce Miller, Christoph Borchers, Bruce M McManus, Raymond T Ng, Don D Sin
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in considerable morbidity and mortality. However, there are no objective biomarkers to diagnose AECOPD. METHODS: We used multiple reaction monitoring mass spectrometry to quantify 129 distinct proteins in plasma samples from patients with COPD. This analytical approach was first performed in a biomarker cohort of patients hospitalized with AECOPD (Cohort A, n = 72). Proteins differentially expressed between AECOPD and convalescent states were chosen using a false discovery rate <0...
2016: PloS One
Dahima Cintron, Melissa Lipford, Laura Larrea-Mantilla, Gabriela Spencer-Bonilla, Robin Lloyd, Michael R Gionfriddo, Shalak Gunjal, Ann M Farrell, Virginia M Miller, Mohammad Hassan Murad
Sleep complaints are reported by 40-60 % of menopausal women. Poor sleep is a risk factor for cardiovascular disease, diabetes, and obesity. The effect of menopausal hormone therapy on sleep quality is unclear. A systematic review and meta-analysis were conducted to summarize the efficacy of menopausal hormone therapy on self-reported sleep quality. Electronic databases (PubMed, Scopus, Ovid MEDLINE, EMBASE, EBM Reviews CENTRAL, and PsycInfo) were searched from 2002 to October 2015. Randomized trials assessing the effect of menopausal hormone therapy with a minimum follow up of 8 weeks were included...
August 11, 2016: Endocrine
Raymond J Osborne, Virginia L Filiaci, Julian C Schink, Robert S Mannel, Kian Behbakht, James S Hoffman, Nick M Spirtos, John K Chan, John A Tidy, David S Miller
OBJECTIVE: To evaluate the efficacy and safety of second uterine curettage in lieu of chemotherapy for patients with low-risk, nonmetastatic gestational trophoblastic neoplasia (GTN) and to evaluate whether response to second curettage is independent of patient age, World Health Organization (WHO) risk score, registration human chorionic gonadotropin (hCG) level, lesion size, and depth of myometrial invasion measured on ultrasound examination. METHODS: This was a cooperative group multicenter prospective phase II study...
September 2016: Obstetrics and Gynecology
Joshua D Hall, Jessica R Harrell, Kimberley W Cohen, Virginia L Miller, Patricia V Phelps, Jeanette G Cook
Certain racial and ethnic groups, individuals with disabilities, and those from low socioeconomic backgrounds remain underrepresented (UR) in the biomedical sciences. This underrepresentation becomes more extreme at each higher education stage. To support UR scholars during the critical transition from baccalaureate to PhD, we established an intensive, 1-yr postbaccalaureate training program. We hypothesized that this intervention would strengthen each participant's competitiveness for leading PhD programs and build a foundation of skills and self-efficacy important for success during and after graduate school...
2016: CBE Life Sciences Education
Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Samantha M Zuk, Jeffrey L Gunter, Carey E Gleason, Whitney Wharton, N Maritza Dowling, Prashanthi Vemuri, Matthew L Senjem, Lynne T Shuster, Kent R Bailey, Walter A Rocca, Clifford R Jack, Sanjay Asthana, Virginia M Miller
OBJECTIVE: To investigate the effects of hormone therapy on brain structure in a randomized, double-blinded, placebo-controlled trial in recently postmenopausal women. METHODS: Participants (aged 42-56 years, within 5-36 months past menopause) in the Kronos Early Estrogen Prevention Study were randomized to (1) 0.45 mg/d oral conjugated equine estrogens (CEE), (2) 50 μg/d transdermal 17β-estradiol, or (3) placebo pills and patch for 48 months. Oral progesterone (200 mg/d) was given to active treatment groups for 12 days each month...
August 30, 2016: Neurology
Kamalini G Ranasinghe, Katherine P Rankin, Peter S Pressman, David C Perry, Iryna V Lobach, William W Seeley, Giovanni Coppola, Anna M Karydas, Lea T Grinberg, Tal Shany-Ur, Suzee E Lee, Gil D Rabinovici, Howard J Rosen, Maria Luisa Gorno-Tempini, Adam L Boxer, Zachary A Miller, Winston Chiong, Mary DeMay, Joel H Kramer, Katherine L Possin, Virginia E Sturm, Brianne M Bettcher, Michael Neylan, Diana D Zackey, Lauren A Nguyen, Robin Ketelle, Nikolas Block, Teresa Q Wu, Alison Dallich, Natanya Russek, Alyssa Caplan, Daniel H Geschwind, Keith A Vossel, Bruce L Miller
IMPORTANCE: Clearer delineation of the phenotypic heterogeneity within behavioral variant frontotemporal dementia (bvFTD) will help uncover underlying biological mechanisms and improve clinicians' ability to predict disease course and to design targeted management strategies. OBJECTIVE: To identify subtypes of bvFTD syndrome based on distinctive patterns of atrophy defined by selective vulnerability of specific functional networks targeted in bvFTD using statistical classification approaches...
September 1, 2016: JAMA Neurology
Janette McDougall, David J DeWit, Megan Nichols, Linda Miller, F Virginia Wright
PURPOSE: Objectives of this longitudinal study were to examine 3-year trajectories of global perceived quality of life (QOL) for youth with chronic health conditions, as obtained from youth and parent reports, and to identify personal and environmental factors associated with the trajectory groups for each perspective. METHODS: Youth with various chronic conditions aged 11-17 years and one of their parents were recruited from eight children's treatment centers...
July 5, 2016: Quality of Life Research
Ann M Moyer, Mariza de Andrade, Richard M Weinshilboum, Virginia M Miller
OBJECTIVE: Onset and symptoms of menopause, and response to hormone therapy (HT) show large interindividual variability. SULT1A1 encodes for a highly expressed enzyme that metabolizes estrogens. We evaluated the relationship between genetic variation in SULT1A1, menopause age, symptoms, and response to HT. METHODS: Women enrolled in the Kronos Early Estrogen Prevention Study at Mayo Clinic were randomized to 48 months of treatment with oral conjugated equine estrogen (n = 34), transdermal 17β-estradiol (E2) (n = 33), or placebo (n = 35)...
August 2016: Menopause: the Journal of the North American Menopause Society
Lena S Sun, Guohua Li, Tonya L K Miller, Cynthia Salorio, Mary W Byrne, David C Bellinger, Caleb Ing, Raymond Park, Jerilynn Radcliffe, Stephen R Hays, Charles J DiMaggio, Timothy J Cooper, Virginia Rauh, Lynne G Maxwell, Ahrim Youn, Francis X McGowan
IMPORTANCE: Exposure of young animals to commonly used anesthetics causes neurotoxicity including impaired neurocognitive function and abnormal behavior. The potential neurocognitive and behavioral effects of anesthesia exposure in young children are thus important to understand. OBJECTIVE: To examine if a single anesthesia exposure in otherwise healthy young children was associated with impaired neurocognitive development and abnormal behavior in later childhood...
June 7, 2016: JAMA: the Journal of the American Medical Association
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