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JOURNAL ARTICLE
Chee Sian Kuan, Mun Teng Wong, Sy Bing Choi, Ching Ching Chang, Yoke Hiang Yee, Habibah A Wahab, Yahaya Mohd Normi, Wei Cun See Too, Ling Ling Few
Klebsiella pneumoniae causes neonatal sepsis and nosocomial infections. One of the strains, K. pneumoniae MGH 78578, shows high level of resistance to multiple microbial agents. In this study, domain family, amino acid sequence and topology analyses were performed on one of its hypothetical protein, YggG (KPN_03358). Structural bioinformatics approaches were used to predict the structure and functionality of YggG protein. The open reading frame (ORF) of yggG, which was a putative metalloprotease gene, was also cloned, expressed and characterized...
2011: International Journal of Molecular Sciences
#22
JOURNAL ARTICLE
Yu-Chieh Liao, Tzu-Wen Huang, Feng-Chi Chen, Pep Charusanti, Jay S J Hong, Hwan-You Chang, Shih-Feng Tsai, Bernhard O Palsson, Chao A Hsiung
Klebsiella pneumoniae is a Gram-negative bacterium of the family Enterobacteriaceae that possesses diverse metabolic capabilities: many strains are leading causes of hospital-acquired infections that are often refractory to multiple antibiotics, yet other strains are metabolically engineered and used for production of commercially valuable chemicals. To study its metabolism, we constructed a genome-scale metabolic model (iYL1228) for strain MGH 78578, experimentally determined its biomass composition, experimentally determined its ability to grow on a broad range of carbon, nitrogen, phosphorus and sulfur sources, and assessed the ability of the model to accurately simulate growth versus no growth on these substrates...
April 2011: Journal of Bacteriology
#23
JOURNAL ARTICLE
Debanu Das, Piotr Kozbial, Gye Won Han, Dennis Carlton, Lukasz Jaroszewski, Polat Abdubek, Tamara Astakhova, Herbert L Axelrod, Constantina Bakolitsa, Connie Chen, Hsiu Ju Chiu, Michelle Chiu, Thomas Clayton, Marc C Deller, Lian Duan, Kyle Ellrott, Marc André Elsliger, Dustin Ernst, Carol L Farr, Julie Feuerhelm, Anna Grzechnik, Joanna C Grant, Kevin K Jin, Hope A Johnson, Heath E Klock, Mark W Knuth, S Sri Krishna, Abhinav Kumar, David Marciano, Daniel McMullan, Mitchell D Miller, Andrew T Morse, Edward Nigoghossian, Amanda Nopakun, Linda Okach, Silvya Oommachen, Jessica Paulsen, Christina Puckett, Ron Reyes, Christopher L Rife, Natasha Sefcovic, Henry J Tien, Christine B Trame, Henry van den Bedem, Dana Weekes, Tiffany Wooten, Qingping Xu, Keith O Hodgson, John Wooley, Ashley M Deacon, Adam Godzik, Scott A Lesley, Ian A Wilson
KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA...
October 1, 2010: Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
#24
JOURNAL ARTICLE
Jingjing Shen, Yongfeng Li, Xing Huang, Xinyan Yu, Jian He, Shunpeng Li
Acetohydroxyacid synthase (AHAS) catalyses the first reaction in the pathway for synthesis of the branched-chain amino acids. AHAS is the target for sulfonylurea, imidazolinone and other AHAS-inhibitor herbicides. Herbicides-resistant AHAS genes have potential application in plant transgenetic engineering and development of new generation herbicide. The AHAS isozyme genes ilvBN, ilvGM and ilvIH were cloned from metsulfuron-methyl resistant strain Klebsiella sp. HR11 and metsulfuron-methyl sensitive strain Klebsiella pneumoniae MGH 78578...
July 2009: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
#25
JOURNAL ARTICLE
Ying-Tsong Chen, Tsai-Lien Liao, Keh-Ming Wu, Tsai-Ling Lauderdale, Jing-Jou Yan, I-Wen Huang, Min-Chi Lu, Yi-Chyi Lai, Yen-Ming Liu, Hung-Yu Shu, Jin-Town Wang, Ih-Jen Su, Shih-Feng Tsai
BACKGROUND: It has long been recognized that Klebsiella pneumoniae can grow anaerobically on citrate. Genes responsible for citrate fermentation of K. pneumoniae were known to be located in a 13-kb gene cluster on the chromosome. By whole genome comparison of the available K. pneumoniae sequences (MGH 78578, 342, and NTUH-K2044), however, we discovered that the fermentation gene cluster was present in MGH 78578 and 342, but absent in NTUH-K2044. In the present study, the previously unknown genome diversity of citrate fermentation among K...
2009: BMC Microbiology
#26
JOURNAL ARTICLE
Xuan Ding Wang, Jia Chang Cai, Hong Wei Zhou, Rong Zhang, Gong-Xiang Chen
Two carbapenem-non-susceptible Klebsiella pneumoniae isolates, Z2554 and Z2110, were collected from a hospital in China and analysed by PFGE. K. pneumoniae Z2554 and Z2110 were genetically unrelated and showed resistance to ertapenem, and reduced susceptibility to imipenem and meropenem. Analysis of their beta-lactamases indicated that K. pneumoniae Z2554 produced TEM-1 and CTX-M-14 beta-lactamases, whilst Z2110 produced a plasmid-mediated AmpC beta-lactamase, DHA-1, in addition to TEM-1 and CTX-M-14. SDS-PAGE analysis of the outer-membrane proteins (OMPs) revealed that both isolates lacked an OMP of approximately 39 kDa (OmpK36), whilst Z2110 had an additional protein with an approximate molecular mass of 26 kDa...
September 2009: Journal of Medical Microbiology
#27
COMPARATIVE STUDY
Keh-Ming Wu, Ling-Hui Li, Jing-Jou Yan, Nina Tsao, Tsai-Lien Liao, Hui-Chi Tsai, Chang-Phone Fung, Hsiang-Ju Chen, Yen-Ming Liu, Jin-Tung Wang, Chi-Tai Fang, Shan-Chwen Chang, Hung-Yu Shu, Tze-Tze Liu, Ying-Tsong Chen, Yih-Ru Shiau, Tsai-Ling Lauderdale, Ih-Jen Su, Ralph Kirby, Shih-Feng Tsai
Nosocomial infections caused by antibiotic-resistant Klebsiella pneumoniae are emerging as a major health problem worldwide, while community-acquired K. pneumoniae infections present with a range of diverse clinical pictures in different geographic areas. In particular, an invasive form of K. pneumoniae that causes liver abscesses was first observed in Asia and then was found worldwide. We are interested in how differences in gene content of the same species result in different diseases. Thus, we sequenced the whole genome of K...
July 2009: Journal of Bacteriology
#28
JOURNAL ARTICLE
Huei-Chi Chou, Cha-Ze Lee, Li-Chen Ma, Chi-Tai Fang, Shan-Chwen Chang, Jin-Town Wang
Klebsiella pneumoniae liver abscess with metastatic complications is an emerging infectious disease in Taiwan. To identify genes associated with liver infection, we used a DNA microarray to compare the transcriptional profiles of three strains causing liver abscess and three strains not associated with liver infection. There were 13 clones that showed higher RNA expression levels in the three liver infection strains, and 3 of these 13 clones contained a region that was absent in MGH 78578. Sequencing of the clones revealed the replacement of 149 bp of MGH 78578 with a 21,745-bp fragment in a liver infection strain, NTUH-K2044...
July 2004: Infection and Immunity
#29
COMPARATIVE STUDY
Jibin Sun, Joop van den Heuvel, Philippe Soucaille, Yinbo Qu, An-Ping Zeng
The dihydroxyacetone (dha) regulon of bacteria encodes genes for the anaerobic metabolism of glycerol. In this work, genomic data are used to analyze and compare the dha regulon and related genes in different organisms in silico with respect to gene organization, sequence similarity, and possible functions. Database searches showed that among the organisms, the genomes of which have been sequenced so far, only two, i.e., Klebsiella pneumoniae MGH 78578 and Clostridium perfringens contain a complete dha regulon bearing all known enzymes...
March 2003: Biotechnology Progress
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