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MiRNA stroke

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https://www.readbyqxmd.com/read/29137141/steroid-and-xenobiotic-receptor-signalling-in-apoptosis-and-autophagy-of-the-nervous-system
#1
REVIEW
Agnieszka Wnuk, Małgorzata Kajta
Apoptosis and autophagy are involved in neural development and in the response of the nervous system to a variety of insults. Apoptosis is responsible for cell elimination, whereas autophagy can eliminate the cells or keep them alive, even in conditions lacking trophic factors. Therefore, both processes may function synergistically or antagonistically. Steroid and xenobiotic receptors are regulators of apoptosis and autophagy; however, their actions in various pathologies are complex. In general, the estrogen (ER), progesterone (PR), and mineralocorticoid (MR) receptors mediate anti-apoptotic signalling, whereas the androgen (AR) and glucocorticoid (GR) receptors participate in pro-apoptotic pathways...
November 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29128328/circulating-micrornas-as-biomarkers-for-acute-ischemic-stroke-a-systematic-review
#2
Brittany Dewdney, Alexandra Trollope, Joseph Moxon, Diana Thomas Manapurathe, Erik Biros, Jonathan Golledge
BACKGROUND: Acute ischemic stroke is a leading cause of death and disability worldwide. Unlike myocardial infarction, there is no current blood test to diagnose acute ischemic stroke. MicroRNAs (miRNAs) are very stable in the blood and have been suggested as potential diagnostic markers. MATERIALS AND METHODS: This review aimed to systematically assess case-control studies investigating the association of circulating miRNAs with acute ischemic stroke. Medline, CINAHL, Cochrane Library, Web of Science, Scopus, and PubMed were searched for studies that examined the association of circulating miRNAs in patients with acute ischemic stroke...
November 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29113388/association-of-mir-146a-mir-149-mir-196a2-mir-499-gene-polymorphisms-with-ischemic-stroke-in-a-chinese-people
#3
Hong-Cheng Luo, Qi-Sheng Luo, Chun-Fang Wang, Ming Lei, Bei-Lin Li, Ye-Sheng Wei
This study aimed to investigate genetic polymorphisms of miR-146a, miR-149, miR-196a2, and miR-499 and genetic susceptibility of ischemic stroke in the population of Guangxi in China. A case-control study was used to investigate miRNAs genetic polymorphisms in 298 patients with ischemic stroke and 303 healthy controls. Single-base extension polymerase chain reaction genotyping principle was used to detect genetic polymorphisms of miRNAs,and the relationship of genotype in each group and blood lipid was compared and analyzed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113076/gene-expression-analysis-of-the-effect-of-ischemic-infarction-in-whole-blood
#4
Ayako Takuma, Arata Abe, Yoshikazu Saito, Chikako Nito, Masayuki Ueda, Yoshiro Ishimaru, Hideki Harada, Keiko Abe, Kazumi Kimura, Tomiko Asakura
Given the abundance of stroke patients and deaths from stroke worldwide, many studies concerning the aftermath of stroke are being carried out. To reveal the precise effect of ischemic infarction, we conducted a comprehensive gene expression analysis. Alongside a middle cerebral artery occlusion (MCAO) Sprague-Dawley rat model, we used a group undergoing sham surgery for comparison, which was the same as MCAO surgery but without blood vessel occlusion. Subsequently, infarction of the brains of MCAO-treated rats occurred, but did not occur in the sham-treated rats...
November 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29104807/neural-vascular-mechanism-for-the-cerebral-blood-flow-autoregulation-after-hemorrhagic-stroke
#5
REVIEW
Ming Xiao, Qiang Li, Hua Feng, Le Zhang, Yujie Chen
During the initial stages of hemorrhagic stroke, including intracerebral hemorrhage and subarachnoid hemorrhage, the reflex mechanisms are activated to protect cerebral perfusion, but secondary dysfunction of cerebral flow autoregulation will eventually reduce global cerebral blood flow and the delivery of metabolic substrates, leading to generalized cerebral ischemia, hypoxia, and ultimately, neuronal cell death. Cerebral blood flow is controlled by various regulatory mechanisms, including prevailing arterial pressure, intracranial pressure, arterial blood gases, neural activity, and metabolic demand...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29104534/mir-148b-regulates-proliferation-and-differentiation-of-neural-stem-cells-via-wnt-%C3%AE-catenin-signaling-in-rat-ischemic-stroke-model
#6
Jingru Wang, Tuanzhi Chen, Guangzhen Shan
Stroke is the second leading cause of death worldwide. Stroke induced proliferation and differentiation of neural stem cells (NSCs) that have been proven to participate in ischemic brain repair. However, molecular mechanisms that regulate neurogenesis have not been fully investigated. MicroRNAs play an important role in the neurological repairing process and impact stroke recovery outcome. MiRNA-148b has been reported to regulate cell proliferation in tumor cells, but its role in NSCs after ischemic stroke remains unknown...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29101647/plasma-mir-124-is-a-promising-candidate-biomarker-for-human-intracerebral-hemorrhage-stroke
#7
Zifeng Wang, Gang Lu, Johnny Sze, Yao Liu, Sheng Lin, Hong Yao, Ji Zhang, Dan Xie, Quentin Liu, Hsiang-Fu Kung, Marie Chia-Mi Lin, Wai Sang Poon
Stroke causes death or long-term disabilities and threatens the general health of the population worldwide. Recent studies have suggested that miRNAs are dysregulated and can be used as biomarkers for diagnosis and prognosis in stroke. The intracerebral hemorrhage (ICH) accounts for 15% of all the stroke cases. However, at present, little is known regarding the functions and clinical implications of miRNAs in ICH. In the present study, we established the collagenase-induced rat ICH model to mimic human ICH syndrome...
November 3, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29064597/mir-23b-3p-and-mir-125b-5p-downregulate-apo-a-expression-by-targeting-ets1-in-hepg2-cells
#8
Jun-Fa Zeng, Zhao-Lin Zeng, Kai Zhang, Yue Zhao, Ya-Mi Liu, Jiao-Jiao Chen, Hai Tong, Dang-Heng Wei, Zhi-Sheng Jiang, Zuo Wang
High concentrations of plasma lipoprotein(a) [Lp(a)] have been inferred to be an independent risk factor for cardiovascular and cerebrovascular diseases, such as coronary artery diseases, restenosis, and stroke. Apolipoprotein(a) [apo(a)] is one of the most important components of Lp(a) and contributes greatly to the increased concentration of plasma Lp(a). As a critical positive transacting factor of apo(a) gene, Ets1 has been proven as a target gene of several miRNAs, such as miR-193b, miR-125b-5p, miR-200b, miR-1, and miR-499...
October 24, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29057271/overexpression-of-microrna-145-ameliorates-astrocyte-injury-by-targeting-aquaporin-4-in-cerebral-ischemic-stroke
#9
Lifang Zheng, Wei Cheng, Xijia Wang, Zhigang Yang, Xiangling Zhou, Chunlian Pan
Cerebral ischemic stroke, which affects the global population, is a major disease with high incidence, mortality, and disability. Accumulating evidence has indicated that abnormal microRNA (miRNA) expression plays essential roles in the pathologies of ischemic stroke. Yet, the underlying regulatory mechanism of miRNAs in cerebral ischemic stroke remains unclear. We investigated the role of miR-145 in cerebral ischemic stroke and its potential mechanism in a model using primary cultured astrocytes. We detected the expression levels of miR-145 and its target gene AQP4 and assessed the role of miR-145 in cell death and apoptosis caused by oxygen-glucose deprivation (OGD)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29039453/microrna-125a-3p-is-involved-in-early-behavioral-disorders-in-stroke-afflicted-rats-through-the-regulation-of-cadm2
#10
Yuqing Liu, Yunjun Li, Zhenxing Ren, Wenwen Si, Yiwei Li, Gang Wei, Wenguang Zhao, Jianhong Zhou, Yage Tian, Dongfeng Chen
Ischemic strokes carry a significant risk of mortality and recurrent vascular events. Recent studies suggest that changes in microRNAs (miRNAs or miRs) may affect the development of the stroke. However, few studies have investigated the role of miRNAs in behavioral disorder in early stroke. In the present study, animal models of middle cerebral artery occlusion (MCAO) are used, as well as a cell model of neurite outgrowth to further investigate the role of miRNAs in targeting synapse-associated proteins expression in early stroke...
October 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28985553/lncrnas-hif1a-as2-facilitates-the-up-regulation-of-hif-1%C3%AE-by-sponging-to-mir-153-3p-whereby-promoting-angiogenesis-in-huvecs-in-hypoxia
#11
Lingjuan Li, Mingyue Wang, Zhujun Mei, Wenfeng Cao, Yun Yang, Yanmei Wang, An Wen
Angiogenesis serves as an important protective mechanism against ischemic stroke, because angiogenesis promotes the generation of collateral circulation and consequently improves the blood supply to cerebral infraction areas. Long noncoding RNAs (lncRNAs), which can act as a competing endogenous RNA, mediate protein-coding gene expression by sponging miRNA. Based on previous studies, the present study hypothesized that lncRNAs HIF1A-AS2 by sponging to miR-153-3p might regulate expression of HIF-1α and its down-stream targets, thereby influencing angiogenesis in hypoxia...
October 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28982331/plasma-exosomal-mir-422a-and-mir-125b-2-3p-serve-as-biomarkers-for-ischemic-stroke
#12
Dong-Bin Li, Jing-Li Liu, Wei Wang, Ru-Ying Li, Dong-Ju Yu, Xiao-Yan Lan, Jin-Pin Li
BACKGROUND: MircroRNA (MiRNA) levels are associated with disease pathophysiology and are high in plasma exosomes. Plasma exosomal miRNAs serve as potential therapeutic targets and diagnosis biomarkers in some diseases but few studies have examined them in ischemic stroke (IS). Therefore, we explored the potential predictive value of plasma exosomal miR-422a and miR-125b-2-3p in different IS phases (acute and subacute phases). METHODS: Fifty-five IS patients and 25 age and sex matched healthy controls were recruited...
October 5, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28924010/microrna-1906-a-novel-regulator-of-toll-like-receptor-4-ameliorates-ischemic-injury-after-experimental-stroke-in-mice
#13
Xiaomeng Xu, Zhuoyu Wen, Nan Zhao, Xiaohui Xu, Fang Wang, Jie Gao, Yongjun Jiang, Xinfeng Liu
Toll-like receptor 4 (TLR4) is a proinflammatory cascade initiator in poststroke inflammation. In this study, miR-1906, a novel regulator of TLR4, was identified via in silico analysis and microRNA profiling in male adult mice and its expression was then quantitated in the ischemic hemisphere. We found miR-1906 to be significantly brain enriched in the ischemic hemisphere and even more drastically enriched in the peri-infarct regions. Furthermore, in vitro experiments demonstrated that, during oxygen-glucose deprivation, miR-1906 expression was increased in glial cells but decreased in neurons...
October 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28892656/plasma-let-7i-and-mir-15a-expression-are-associated-with-the-effect-of-recombinant-tissue-plasminogen-activator-treatment-in-acute-ischemic-stroke-patients
#14
Wei Xiang, Canhui Tian, Jingru Lin, Xiaohui Wu, Guanlai Pang, Liang Zhou, Suyue Pan, Zhen Deng
Circulating microRNAs (miRNAs) have been reported as diagnosis biomarkers and predictors in acute ischemic stroke (AIS). However, how the expression of circulating miRNAs changes after recombinant tissue plasminogen activator (rt-PA) treatment in AIS patients is still unknown. OBJECTIVE: To determine the expression of circulating miRNAs in AIS patients receiving rt-PA treatment and those not receiving it. METHODS: Blood samples were collected 24h after onset from 40 AIS patients receiving rt-PA treatment and 46 AIS patients (admission at 8-24h of onset) not receiving rt-PA treatment...
September 5, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28875333/circulating-pro-angiogenic-and-anti-angiogenic-microrna-expressions-in-patients-with-acute-ischemic-stroke-and-their-association-with-disease-severity
#15
Fuqiang Jin, Jie Xing
The main objectives of this study are to evaluate 28 selected pro-angiogenic and anti-angiogenic microRNA (miRNA) expressions in plasma of acute ischemic stroke (AIS) patients and controls and to assess the correlations of these miRNAs with risk and severity of AIS. In the exploring stage, 10 AIS patients and 10 controls with vascular risk factors were enrolled. And in the validating stage, 106 AIS patients and 110 controls with the same eligibility were recruited. Blood samples were collected from participants within 24 h post the onset of symptoms, and plasma levels of miRNAs were evaluated by the qPCR method...
November 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28854438/down-regulation-of-lncrna-malat1-attenuates-neuronal-cell-death-through-suppressing-beclin1-dependent-autophagy-by-regulating-mir-30a-in-cerebral-ischemic-stroke
#16
Dong Guo, Ji Ma, Lei Yan, Tengfei Li, Zhiguo Li, Xinwei Han, Shaofeng Shui
BACKGROUND/AIMS: LncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be highly expressed in an in vitro mimic of ischemic stroke conditions. However, the exact biological role of MALAT1 and its underlying mechanism in ischemic stroke remain to be elucidated. METHODS: The roles of MALAT1 and miR-30a on cell death and infarct volume and autophagy were evaluated in experimental ischemic stroke. The relationships between miR-30a and MALAT1, Beclin1 were confirmed by luciferase reporter assay...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28842356/impact-of-micrornas-on-ischemic-stroke-from-pre-to-post-disease
#17
REVIEW
Guangwen Li, Kahlilia C Morris-Blanco, Mary S Lopez, Tuo Yang, Haiping Zhao, Raghu Vemuganti, Yumin Luo
Stroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttranscriptional gene silencing in both the physiology of brain development and pathology of ischemic stroke...
August 24, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28799067/mir-448-promotes-vascular-smooth-muscle-cell-proliferation-and-migration-in-through-directly-targeting-mef2c
#18
Ruihong Zhang, Li Sui, Xiaojian Hong, Mao Yang, Weimin Li
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is a critical process in various cardiovascular diseases such as coronary artery disease (CAD), atherosclerosis, stroke, and hypertension. MicroRNAs (miRNAs) are small, short, and noncoding RNAs that inhibit gene expression through binding to the 3'-UTR (3' untranslated regions) of target gene mRNAs. We showed that the expression of miR-448 was upregulated in VSMCs from coronary atherosclerotic plaques compared with normal coronary artery tissues...
October 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28775076/the-involvement-of-mirna-in-carotid-related-stroke
#19
REVIEW
Pierre Maitrias, Valérie Metzinger-Le Meuth, Joseph Nader, Thierry Reix, Thierry Caus, Laurent Metzinger
Cardiovascular disease is the leading cause of morbidity and mortality in developed countries. Stroke is associated with a marked disability burden and has a major economic impact; this is especially true for carotid artery stroke. Major advances in primary and secondary prevention during the last few decades have helped to tackle this public health problem. However, better knowledge of the physiopathology of stroke and its underlying genetic mechanisms is needed to improve diagnosis and therapy. miRNAs are an important, recently identified class of post-transcriptional regulators of gene expression and are known to be involved in cerebrovascular disease...
September 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28761412/immunomodulators-and-micrornas-as-neurorestorative-therapy-for-ischemic-stroke
#20
REVIEW
Bridget Martinez, Philip V Peplow
Most of all strokes are ischemic due to occlusion of a vessel, and comprise two main types, thrombotic and embolic. Inflammation and immune response play an important role in the outcome of ischemic stroke. Pharmaceutical and cell-based therapies with immunomodulatory properties could be of benefit in treating ischemic stroke. Possible changes in microRNAs brought about by immunomodulatory treatments may be important. The pharmaceutical studies described in this review have identified several differentially regulated miRNAs associated with disregulation of mRNA targets or the upregulation of several neuroprotective genes, thereby highlighting the potential neuroprotective roles of specific miRNAs such as miR-762, -1892, -200a, -145...
June 2017: Neural Regeneration Research
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