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ATCC 43816

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https://www.readbyqxmd.com/read/25968331/oncocin-onc72-is-efficacious-against-antibiotic-susceptible-klebsiella-pneumoniae-atcc-43816-in-a-murine-thigh-infection-model
#1
Daniel Knappe, Knut Adermann, Ralf Hoffmann
Oncocins and apidaecins are short proline-rich antimicrobial peptides (PrAMPs) representing novel antibiotic drug lead compounds that kill bacteria after internalization and inhibition of intracellular targets (e.g. 70S ribosome and DnaK). Oncocin Onc72 is highly active against Gram-negative bacteria in vitro and in vivo protecting mice in systemic infection models with Escherichia coli and KPC-producing Klebsiella pneumoniae. Here we studied its efficacy in a murine thigh infection model using meropenem as antibiotic comparator that had a 44-fold higher molar in vitro activity than Onc72...
November 2015: Biopolymers
https://www.readbyqxmd.com/read/25291761/complete-genome-sequence-of-klebsiella-pneumoniae-strain-atcc-43816-kppr1-a-rifampin-resistant-mutant-commonly-used-in-animal-genetic-and-molecular-biology-studies
#2
Christopher A Broberg, Weisheng Wu, James D Cavalcoli, Virginia L Miller, Michael A Bachman
Klebsiella pneumoniae is an urgent public health threat due to the spread of carbapenem-resistant strains causing serious, and frequently fatal, infections. To facilitate genetic, molecular, and immunological studies of this pathogen, we report the complete chromosomal sequence of a genetically tractable, prototypical strain used in animal models.
2014: Genome Announcements
https://www.readbyqxmd.com/read/25203254/correlation-of-klebsiella-pneumoniae-comparative-genetic-analyses-with-virulence-profiles-in-a-murine-respiratory-disease-model
#3
Ramy A Fodah, Jacob B Scott, Hok-Hei Tam, Pearlly Yan, Tia L Pfeffer, Ralf Bundschuh, Jonathan M Warawa
Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied K. pneumoniae strain which is capable of causing an acute respiratory disease in surrogate animal models. In this study, we performed sequencing of the ATCC 43816 genome to support future efforts characterizing genetic elements required for disease. Furthermore, we performed comparative genetic analyses to the previously sequenced genomes from NTUH-K2044 and MGH 78578 to gain an understanding of the conservation of known virulence determinants amongst the three strains...
2014: PloS One
https://www.readbyqxmd.com/read/22226964/klebsiella-pneumoniae-induces-an-inflammatory-response-in-human-retinal-pigmented-epithelial-cells
#4
Andreas Pollreisz, Brian Rafferty, Emil Kozarov, Evanthia Lalla
PURPOSE: The retinal pigment epithelium (RPE) is a barrier to Klebsiella pneumoniae infection in endogenous endophthalmitis. Nevertheless, the inflammatory response of RPE cells upon interaction with this pathogen has not been studied. Here we tested the hypothesis that K. pneumoniae induces an inflammatory response in human retinal epithelial cells. METHODS: In this study we set out to investigate the effects of whole K. pneumoniae and of its lipopolysaccharide on RPE cells in vitro using bacterial invasion and cytotoxicity assays, fluorescent microscopy and ELISA...
February 3, 2012: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/19597641/induction-of-resistance-to-respiratory-tract-infection-with-klebsiella-pneumoniae-in-mice-fed-on-a-diet-supplemented-with-tulsi-ocimum-sanctum-and-clove-syzgium-aromaticum-oils
#5
Archana Saini, Saroj Sharma, Sanjay Chhibber
BACKGROUND AND PURPOSE: The impact of diet and specific food groups on respiratory tract infections has been widely recognized in recent years. This study was conducted to study the effect of tulsi (Ocimum sanctum) oil and clove (Syzgium aromaticum) oil on the susceptibility of experimental mice to respiratory tract infection. METHODS: The effect of 2 different regimens of short-term (15 days) and long-term (30 days) feeding with tulsi oil and clove oil on the course of Klebsiella pneumoniae American Type Culture Collection 43816 infection in the lungs of mice was analyzed...
April 2009: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/15194132/reduction-in-the-bactericidal-activity-of-selected-cathelicidin-peptides-by-bovine-calf-serum-or-exogenous-endotoxin
#6
Karen H Bartlett, Paul B McCray, Peter S Thorne
Synthetic cathelicidin peptides exhibit enhanced antimicrobial action and avid binding to LPS, thereby detoxifying the action of endotoxin released from degrading bacteria. A series of cathelicidin antimicrobial peptide (CAP) and sheep myeloid antimicrobial peptide (SMAP) congeners were examined to determine whether LPS-binding could predict other beneficial characteristics of the peptides. The peptides were challenged in complex media with bovine calf serum or LPS, and their ability to kill the Gram negative pathogens Klebsiella pneumoniae (ATCC 43816) or Pseudomonas aeruginosa (PA103) was then assessed...
June 2004: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/14638504/pharmacodynamics-of-the-new-des-f-6-quinolone-garenoxacin-in-a-murine-thigh-infection-model
#7
D Andes, W A Craig
Garenoxacin is a new des-F(6)-quinolone with broad-spectrum activity against both gram-positive cocci and gram-negative bacilli. We used the neutropenic murine thigh infection model to characterize the time course of antimicrobial activity of garenoxacin and determine which pharmacokinetic-pharmacodynamic (PK-PD) parameter best correlated with efficacy. Serum drug levels following three fourfold-escalating single-dose levels of garenoxacin were measured by microbiologic assay. In vivo postantibiotic effects (PAEs) were determined after doses of 16 and 64 mg/kg of body weight...
December 2003: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/10722495/in-vivo-pharmacodynamic-activities-of-two-glycylcyclines-gar-936-and-way-152-288-against-various-gram-positive-and-gram-negative-bacteria
#8
M L van Ogtrop, D Andes, T J Stamstad, B Conklin, W J Weiss, W A Craig, O Vesga
The in vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) were assessed in an experimental murine thigh infection model in neutropenic mice. Mice were infected with one of several strains of Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli, or Klebsiella pneumoniae. Most infections were treated with a twice-daily dosing schedule, with administration of 0.75 to 192 mg of GAR-936 or WAY 152,288 per kg of body weight. A maximum-effect dose-response model was used to calculate the dose that produced a net bacteriostatic effect over 24 h of therapy...
April 2000: Antimicrobial Agents and Chemotherapy
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