keyword
MENU ▼
Read by QxMD icon Read
search

Experimental techniques

keyword
https://www.readbyqxmd.com/read/28719062/immersive-virtual-reality-as-a-teaching-tool-for-neuroanatomy
#1
Katelyn Stepan, Joshua Zeiger, Stephanie Hanchuk, Anthony Del Signore, Raj Shrivastava, Satish Govindaraj, Alfred Iloreta
BACKGROUND: Three-dimensional (3D) computer modeling and interactive virtual reality (VR) simulation are validated teaching techniques used throughout medical disciplines. Little objective data exists supporting its use in teaching clinical anatomy. Learner motivation is thought to limit the rate of utilization of such novel technologies. The purpose of this study is to evaluate the effectiveness, satisfaction, and motivation associated with immersive VR simulation in teaching medical students neuroanatomy...
July 18, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28718804/electromagnetic-differential-measuring-method-application-in-microstrip-sensors-developing
#2
Francisco Javier Ferrández-Pastor, Juan Manuel García-Chamizo, Mario Nieto-Hidalgo
Electromagnetic radiation is energy that interacts with matter. The interaction process is of great importance to the sensing applications that characterize material media. Parameters like constant dielectric represent matter characteristics and they are identified using emission, interaction and reception of electromagnetic radiation in adapted environmental conditions. How the electromagnetic wave responds when it interacts with the material media depends on the range of frequency used and the medium parameters...
July 18, 2017: Sensors
https://www.readbyqxmd.com/read/28718782/prediction-of-protein-hotspots-from-whole-protein-sequences-by-a-random-projection-ensemble-system
#3
Jinjian Jiang, Nian Wang, Peng Chen, Chunhou Zheng, Bing Wang
Hotspot residues are important in the determination of protein-protein interactions, and they always perform specific functions in biological processes. The determination of hotspot residues is by the commonly-used method of alanine scanning mutagenesis experiments, which is always costly and time consuming. To address this issue, computational methods have been developed. Most of them are structure based, i.e., using the information of solved protein structures. However, the number of solved protein structures is extremely less than that of sequences...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28718773/mouse-epileptic-seizure-detection-with-multiple-eeg-features-and-simple-thresholding-technique
#4
Quang M Tieng, Ashwin Anbazhagan, Min Chen, David Charles Reutens
Epilepsy is a common neurological disorder characterized by recurrent, unprovoked seizures. The search for new treatments for seizures and epilepsy relies upon studies in animal models of epilepsy. To capture data on seizures, many applications require prolonged electroencephalography (EEG) with recordings that generate voluminous data. The desire for efficient evaluation of these recordings motivates the development of automated seizure detection algorithms. Approach: A new seizure detection method is proposed, based on multiple features and a simple thresholding technique...
July 18, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28718358/an-updated-method-for-the-jugular-catheterization-of-grower-pigs-for-repeated-blood-sampling-following-an-oral-glucose-tolerance-test
#5
Anton M Pluschke, Gregory S Simmons, Helen L Keates, Ranald D A Cameron, Dagong Zhang, John D Wright, Barbara A Williams
Jugular catheterization is a common procedure used under experimental conditions. However, there is considerable variation in the reported techniques, particularly for grower pigs (>40 kg and <60 kg) when larger volumes of blood per sample (>10 mL) are required. This paper provides a complete methodology including the use of current equipment and anaesthetic regimen for grower pigs. This surgical jugular catheterization method was carried out in 30 large white grower pigs. Firstly, the pigs were habituated to human handling for at least two weeks prior to surgery...
August 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28717842/selective-matrix-metalloproteinase-inhibition-increases-breaking-strength-and-reduces-anastomotic-leakage-in-experimentally-obstructed-colon
#6
Peter-Martin Krarup, Mikkel Eld, Lars Nannestad Jorgensen, Mark Berner Hansen, Magnus S Ågren
PURPOSE: Colonic obstruction causes loss of collagen and impairment of anastomotic integrity by matrix metalloproteinases (MMPs). Unexpectedly, pharmacological MMP inhibition increased anastomotic leakage (AL) in obstructed colon possibly due to the non-selective nature of these compounds and the experimental model applied. We therefore studied the effects of selective MMP inhibition on the healing of anastomoses in colon obstructed by a novel laparoscopic technique. METHODS: Left colon was obstructed in 38 male Sprague-Dawley rats (226-284 g)...
July 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28717561/diattenuation-of-brain-tissue-and-its-impact-on-3d-polarized-light-imaging
#7
Miriam Menzel, Julia Reckfort, Daniel Weigand, Hasan Köse, Katrin Amunts, Markus Axer
3D-polarized light imaging (3D-PLI) reconstructs nerve fibers in histological brain sections by measuring their birefringence. This study investigates another effect caused by the optical anisotropy of brain tissue - diattenuation. Based on numerical and experimental studies and a complete analytical description of the optical system, the diattenuation was determined to be below 4 % in rat brain tissue. It was demonstrated that the diattenuation effect has negligible impact on the fiber orientations derived by 3D-PLI...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28717560/ultra-high-speed-digital-micro-mirror-device-based-ptychographic-iterative-engine-method
#8
Aihui Sun, Xiaoliang He, Yan Kong, Haoyang Cui, Xiaojun Song, Liang Xue, Shouyu Wang, Cheng Liu
To reduce the long data acquisition time of the common mechanical scanning based Ptychographic Iterative Engine (PIE) technique, the digital micro-mirror device (DMD) is used to form the fast scanning illumination on the sample. Since the transverse mechanical scanning in the common PIE is replaced by the on/off switching of the micro-mirrors, the data acquisition time can be reduced from more than 15 minutes to less than 20 seconds for recording 12 × 10 diffraction patterns to cover the same field of 147...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28717422/exosomes-purified-from-a-single-cell-type-have-diverse-morphology
#9
Davide Zabeo, Aleksander Cvjetkovic, Cecilia Lässer, Martin Schorb, Jan Lötvall, Johanna L Höög
Extracellular vesicles (EVs) are produced by all known organisms and are important for cell communication and physiology. Great morphological diversity has been described regarding EVs found in body fluids such as blood plasma, breast milk, and ejaculate. However, a detailed morphological analysis has never been performed on exosomes when purified from a single cell type. In this study we analysed and quantified, via multiple electron microscopy techniques, the morphology of exosomes purified from the human mast cell line HMC-1...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28717065/comparison-of-postoperative-pain-and-inflammation-reaction-in-dogs-undergoing-preventive-laparoscopic-assisted-and-incisional-gastropexy
#10
Tomoya Haraguchi, Shiho Kimura, Harumichi Itoh, Shinpei Nishikawa, Masato Hiyama, Kenji Tani, Toshie Iseri, Yoshiki Itoh, Munekazu Nakaichi, Yasuho Taura, Kazuhito Itamoto
This study compared the effects of postoperative pain and inflammation reaction after preventive laparoscopic-assisted gastropexy (LAG) and incisional gastropexy (IG) in 10 clinically normal Beagles. Surgical time, incision length, visual analog scale (VAS) score, University of Melbourne Pain Scale (UMPS) score, and plasma C-reactive protein (CRP), plasma cortisol (COR), and serum interleukin-6 (IL-6) levels were evaluated. The VAS and UMPS scores and COR and IL-6 levels were recorded at 0.5, 1, 2, 4, 8, 12, 18 and 24 hr after surgery...
July 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28716945/evaluating-optimal-therapy-robustness-by-virtual-expansion-of-a-sample-population-with-a-case-study-in-cancer-immunotherapy
#11
Syndi Barish, Michael F Ochs, Eduardo D Sontag, Jana L Gevertz
Cancer is a highly heterogeneous disease, exhibiting spatial and temporal variations that pose challenges for designing robust therapies. Here, we propose the VEPART (Virtual Expansion of Populations for Analyzing Robustness of Therapies) technique as a platform that integrates experimental data, mathematical modeling, and statistical analyses for identifying robust optimal treatment protocols. VEPART begins with time course experimental data for a sample population, and a mathematical model fit to aggregate data from that sample population...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28716664/advances-and-challenges-in-the-search-for-d2-and-d3-dopamine-receptor-selective-compounds
#12
REVIEW
Amy E Moritz, R Benjamin Free, David R Sibley
Compounds that target D2-like dopamine receptors (DRs) are currently used as therapeutics for several neuropsychiatric disorders including schizophrenia (antagonists) and Parkinson's disease (agonists). However, as the D2R and D3R subtypes are highly homologous, creating compounds with sufficient subtype-selectivity as well as drug-like properties for therapeutic use has proved challenging. This review summarizes the progress that has been made in developing D2R- or D3R-selective antagonists and agonists, and also describes the experimental conditions that need to be considered when determining the selectivity of a given compound, as apparent selectivity can vary widely depending on assay conditions...
July 14, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28716627/membrane-proteins-structures-a-review-on-computational-modeling-tools
#13
REVIEW
Jose G Almeida, Antonio J Preto, Panagiotis I Koukos, Alexandre M J J Bonvin, Irina S Moreira
BACKGROUND: Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental methods and provide valuable insights...
July 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28716546/delineating-biological-and-technical-variance-in-single-cell-expression-data
#14
Ángeles Arzalluz-Luque, Guillaume Devailly, Anna Mantsoki, Anagha Joshi
Single cell transcriptomics is becoming a common technique to unravel new biological phenomena whose functional significance can only be understood in the light of differences in gene expression between single cells. The technology is still in its early days and therefore suffers from many technical challenges. This review discusses the continuous effort to identify and systematically characterise various sources of technical variability in single cell expression data and the need to further develop experimental and computational tools and resources to help deal with it...
July 14, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28715442/combining-random-forest-with-multi-block-local-binary-pattern-feature-selection-for-multiclass-head-pose-estimation
#15
Min-Joo Kang, Jung-Kyung Lee, Je-Won Kang
A new head pose estimation technique based on Random Forest (RF) and texture features for facial image analysis using a monocular camera is proposed in this paper, especially about how to efficiently combine the random forest and the features. In the proposed technique a randomized tree with useful attributes is trained to improve estimation accuracy and tolerance of occlusions and illumination. Specifically, a number of features including Multi-scale Block Local Block Pattern (MB-LBP) are extracted from an image, and random features such as the MB-LBP scale parameters, a block coordinate, and a layer of an image pyramid in the feature pool are used for training the tree...
2017: PloS One
https://www.readbyqxmd.com/read/28715023/amorphous-boron-nanorod-as-an-anode-material-for-lithium-ion-batteries-at-room-temperature
#16
Changjian Deng, Miu Lun Lau, Heather M Barkholtz, Haiping Xu, Riley Parrish, Meiyue Olivia Xu, Tao Xu, Yuzi Liu, Hao Wang, Justin G Connell, Kassiopeia A Smith, Hui Xiong
We report an amorphous boron nanorod anode material for lithium-ion batteries prepared through smelting non-toxic boron oxide in liquid lithium. Boron in theory can provide capacity as high as 3099 mA h g(-1) by alloying with Li to form B4Li5. However, experimental studies of the boron anode have been rarely reported for room temperature lithium-ion batteries. Among the reported studies the electrochemical activity and cycling performance of the bulk crystalline boron anode material are poor at room temperature...
July 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28714927/development-and-application-of-a-structural-health-monitoring-system-based-on-wireless-smart-aggregates
#17
Shi Yan, Haoyan Ma, Peng Li, Gangbing Song, Jianxin Wu
Structural health monitoring (SHM) systems can improve the safety and reliability of structures, reduce maintenance costs, and extend service life. Research on concrete SHMs using piezoelectric-based smart aggregates have reached great achievements. However, the newly developed techniques have not been widely applied in practical engineering, largely due to the wiring problems associated with large-scale structural health monitoring. The cumbersome wiring requires much material and labor work, and more importantly, the associated maintenance work is also very heavy...
July 17, 2017: Sensors
https://www.readbyqxmd.com/read/28714858/hybridization-effects-on-wave-packet-dynamics-in-topological-insulator-thin-films
#18
Abdullah Yar, Muhammad Naeem, Safi Ullah Khan, Kashif Sabeeh
Theoretical study of electron wave packet dynamics in Topological Insulator (TI) thin films is presented. We have investigated real space trajectories and spin dynamics of electron wave packets in TI thin films. Our focus is on the role of hybridization between the electronic states of the two surfaces. This allows us to access the crossover regime of a thick film with no hybridization to a thin film with finite hybridization. We show that the electron wave packet undergoes side-jump motion in addition to zitterbewegung...
July 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28714460/magnetic-behavior-of-metallic-kagome-lattices-tb3ru4al12-and-er3ru4al12
#19
Sanjay Kumar Upadhyay, Kartik K Iyer, E V Sampathkumaran
We report the magnetic behavior of two intermetallic-based kagome lattices, Tb3Ru4Al12 and Er3Ru4Al12, crystallizing in the Gd3Ru4Al2-type hexagonal crystal structure, by measurements in the range 1.8-300 K with bulk experimental techniques (ac and dc magnetization, heat capacity, and magnetoresistance). The main finding is that the Tb compound, known to order antiferromagnetically below (T N =) 22 K, shows glassy characteristics at lower temperatures ([Formula: see text]15 K), thus characterizing this compound as a re-entrant spin-glass...
July 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28714407/update-of-standard-practices-for-new-method-validation-in-forensic-toxicology
#20
Sarah M R Wille, Wim Coucke, Thierry De Baere, Frank T Peters
: International agreement concerning validation guidelines is important as reporting reliable analytical data is the backbone of forensic bioanalytical research and applications. Guidelines such as those provided by the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), the German speaking Gesellschaft für Toxikologie und Forensische Chemie (GTFCH) and the Scientific Working Group of Forensic Toxicology (SWGTOX) provide a standard for fundamental validation parameters such as selectivity, matrix effects, method limits, calibration, accuracy and stability, as well as other parameters such as carryover, dilution integrity and incurred sample reanalysis...
July 14, 2017: Current Pharmaceutical Design
keyword
keyword
20110
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"