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https://www.readbyqxmd.com/read/28537693/surgical-management-of-female-paraurethral-cyst-with-concomitant-stress-urinary-incontinence
#1
Tarik Yonguc, Ibrahim Halil Bozkurt, Salih Polat, Serkan Yarimoglu, Ismail Gulden, Volkan Sen, Suleyman Minareci
Paraurethral cysts are usually asymptomatic and frequently detected incidentally during routine pelvic examination however, patients can present with complaints of a palpable cyst or with lower urinary tract symptoms (LUTS) and also dyspareunia. In most cases, diagnosis can be made on physical examination but for more detailed evaluation and to differentiate from malign lesions ultrasonography (US), voiding cystourethrogram (VCUG), computerized tomography (CT), or magnetic resonance imaging (MRI) can also be used...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28534914/covalent-inhibition-of-protein-tyrosine-phosphatases
#2
REVIEW
Kasi Viswanatharaju Ruddraraju, Zhong-Yin Zhang
Protein tyrosine phosphatases (PTPs) are a large family of 107 signaling enzymes that catalyze the hydrolytic removal of phosphate groups from tyrosine residues in a target protein. The phosphorylation status of tyrosine residues on proteins serve as a ubiquitous mechanism for cellular signal transduction. Aberrant function of PTPs can lead to many human diseases, such as diabetes, obesity, cancer, and autoimmune diseases. As the number of disease relevant PTPs increases, there is urgency in developing highly potent inhibitors that are selective towards specific PTPs...
May 23, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28534327/-modified-stapled-transanal-rectal-resection-combined-with-perioperative-pelvic-floor-biofeedback-therapy-in-the-treatment-of-obstructed-defecation-syndrome
#3
Lei Chen, Fanqi Meng, Tongsen Zhang, Yinan Liu, Shuang Sha, Si Chen, Jiandong Tai
OBJECTIVE: To investigate the clinical efficacy and safety of modified stapled transanal rectal resection (STARR) combined with perioperative pelvic floor biofeedback therapy (POPFBFT) in treating obstructed defecation syndrome (ODS). METHODS: Thirty female ODS patients underwent modified STARR (resection and suture was performed in rectocele with one staple) combined with POPFBFT in Department of Colorectal and Anal Surgery, The First Hospital of Jilin university from October 2013 to March 2015...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28534313/class-based-chronicities-of-suffering-and-seeking-help-comparing-addiction-treatment-programs-in-uganda
#4
Julia Vorhölter
Based on ethnographic fieldwork, this article looks at changing discourses and practices in the field of mental health care in Uganda. In particular, it analyzes two psychotherapeutic institutions designed to treat drug- and alcohol-addiction, and their accessibility and affordability for people from different class backgrounds. The first center is a high-class residential facility near Kampala which offers state-of-the-art addiction therapy, but is affordable only for the rich. The second center, a church-funded organization in Northern Uganda, cares mainly for people from poor, rural families who cannot afford exp/tensive treatment...
May 22, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28532232/a-two-week-double-blind-placebo-controlled-trial-of-viola-odorata-echium-amoenum-and-physalis-alkekengi-mixture-in-symptomatic-benign-prostate-hyperplasia-bph-men
#5
Fatemeh Beiraghdar, Behzad Einollahi, Alireza Ghadyani, Yunes Panahi, Abbas Hadjiakhoondi, Mahdi Vazirian, Ali Salarytabar, Behrad Darvishi
CONTEXT: As an alternative approach, administration of phytotherapeutic agents in management of benign prostate hyperplasia (BPH), is rapidly growing each day. Different authors have indicated effectiveness of Viola odorata L. (Violaceae), Echium amoenum Fisch. & C.A.Mey. (Boraginaceae) and Physalis alkekengi L. (Solanaceae) in treatment of BPH. However, none have reported the beneficial outcomes of the mixture yet. OBJECTIVE: This study evaluates the therapeutical effects of V...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28531770/treatment-consumption-and-treatment-re-enrollment-in-ghb-dependent-patients-in-the-netherlands
#6
Martijn S van Noorden, Ton Mol, Jeroen Wisselink, Wil Kuijpers, Boukje A G Dijkstra
BACKGROUND: The objective of this study was to assess treatment consumption and re-enrollment in treatment in patients with gamma-hydroxybutyrate (GHB)-dependence in Dutch Addiction Treatment Centers (ATCs) in comparison with other addictions. METHODS: A cohort-study using nationwide administrative data from regular Dutch ATCs associated with the Dutch National Alcohol and Drugs Information System (LADIS), covering an estimated 95% of ATCs. We selected in- and out-patients with alcohol, drug and/or behavioral addictions with a first treatment episode in 2008-2011 and consecutive treatments until 2013 (n=71,679)...
May 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28530180/red-eye-a-guide-for-non-specialists
#7
Andreas Frings, Gerd Geerling, Marc Schargus
BACKGROUND: Red eye can arise as a manifestation of many different systemic and ophthalmological diseases. The physician whom the patient first consults for this problem is often not an ophthalmologist. A correct assessment of the urgency of the situation is vitally important for the planning of further diagnostic evaluation and treatment. METHODS: This review is based on pertinent publications retrieved by a selective literature search in PubMed in August 2016 as well as on the authors' own clinical and scientific experience...
April 28, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28530071/-epidemiology-of-over-active-bladder-oab-syndrome
#8
REVIEW
Tamar Eshkoli, David Yohai, Elad Laron, Adi Y Weintraub
An over-active bladder is a common disorder which influences women's health and quality of life. There is difficulty defining the exact prevalence of the disorder since there are various definitions in the literature. The ICS definition from 2002 on the over-active bladder (OAB) syndrome enables more uniformity, by declaring that OAB syndrome is a symptomatic syndrome defined as presence of urgency with or without urinary incontinence, mostly accompanied by frequency and nocturia. In this article we reviewed the current medical literature on the prevalence of the OAB syndrome by focusing on relevant crosssectional and longitudinal studies, the trend changes during life, co-morbidities, the influence of quality of life and the economic burden following the disorder and its treatment...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28530066/-position-statement-on-overactive-bladder
#9
Ilan Grunwald, Kobi Stav, Jacob Golomb, Joseph Abarbanel, Gabriel Gillon, Alexander Greenstein
Bothersome urinary symptoms during the storage phase are common among women and men. These symptoms described as urinary urgency, frequency and nocturia with or without urge urinary incontinence may be caused by various pathologies including bladder overactivity. Diagnosis of an overactive bladder is based on the patient's clinical presentation after exclusion of other disorders that may cause these symptoms. The minimal requirements for a urological evaluation include medical history, physical examination and urinalysis...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28529915/hemolytic-uremic-syndrome-in-adults-a-case-report
#10
Fabiel Gerardo Pérez-Cruz, Patricia Villa-Díaz, María Consuelo Pintado-Delgado, María Loreto Fernández Rodríguez, Ana Blasco-Martínez, María Pérez-Fernández
Thrombotic microangiopathies (TMA) are microvascular occlusive disorders characterized by platelet aggregation and mechanical damage to erythrocytes, clinically characterized by microangiopatic haemolytic anemia, thrombocytopenia and organ injury. We are reporting a case of a woman patient with severe hemolytic uremic syndrome associated to infectious diarrhoea caused by Shiga toxin-producing pathogen, who were admitted to our intensive care unit. The patient described developed as organ injury, neurological failure and acute renal failure, with need of haemodialysis technique...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28527917/spatial-distribution-of-vanadium-and-microbial-community-responses-in-surface-soil-of-panzhihua-mining-and-smelting-area-china
#11
Xuelong Cao, Muhe Diao, Baogang Zhang, Hui Liu, Song Wang, Meng Yang
Spatial distribution of vanadium in surface soils from different processing stages of vanadium-bearing titanomagnetite in Panzhihua mining and smelting area (China) as well as responses of microbial communities including bacteria and fungi to vanadium were investigated by fieldwork and laboratory incubation experiment. The vanadium contents in this region ranged from 149.3 to 4793.6 mg kg(-1), exceeding the soil background value of vanadium in China (82 mg kg(-1)) largely. High-throughput DNA sequencing results showed bacterial communities from different manufacturing locations were quite diverse, but Bacteroidetes and Proteobacteria were abundant in all samples...
May 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28527720/overactive-bladder-oab-a-symptom-in-search-of-a-disease-its-relationship-to-specific-lower-urinary-tract-symptoms-and-conditions
#12
Jason P Van Batavia, Andrew J Combs, Angela M Fast, Kenneth I Glassberg
BACKGROUND: The ICCS defines OAB by the subjective symptom of urgency; detrusor overactivity (DO) is only implied. While no other symptom is required, OAB can also be associated with urinary frequency, decreased functional bladder capacity, and incontinence. OBJECTIVE: We sought to determine how often these associated findings occur in OAB and what if any uroflow/EMG-defined conditions are found to be associated with it. METHODS: The charts of 548 children (231M, 318F; mean age 9...
March 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28525808/characterization-of-post-disaster-environmental-management-for-hazardous-materials-incidents-lessons-learnt-from-the-tianjin-warehouse-explosion-china
#13
Hui Zhang, Huabo Duan, Jian Zuo, MingWei Song, Yukui Zhang, Bo Yang, Yongning Niu
Hazardous Materials Incidents (HMIs) have attracted a growing public concern worldwide. The health risks and environmental implications associated with HMIs are almost invariably severe, and underscore the urgency for sound management. Hazardous Materials Explosion incidents (HMEIs) belong to a category of extremely serious HMIs. Existing studies placed focuses predominately on the promptness and efficiency of emergency responses to HMIs and HMEIs. By contrast, post-disaster environmental management has been largely overlooked...
May 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28525543/fermentable-carbohydrates-fodmaps-exacerbate-functional-gastrointestinal-symptoms-in-patients-with-inflammatory-bowel-disease-a-randomised-double-blind-placebo-controlled-cross-over-re-challenge-trial
#14
Selina R Cox, Alexis C Prince, Clio E Myers, Peter M Irving, James O Lindsay, Miranda C Lomer, Kevin Whelan
Background and Aims: Preliminary evidence suggests fermentable carbohydrate restriction might ameliorate functional gastrointestinal symptoms (FGS) in quiescent inflammatory bowel disease (IBD). Our aim was to determine whether fermentable carbohydrates exacerbate FGS in quiescent IBD using a randomised, double-blinded, placebo-controlled, cross-over, re-challenge trial. Methods: Patients with quiescent IBD and FGS responsive to a low FODMAP diet were allocated to a series of 3-day fermentable carbohydrate challenges in random order (fructan, 12 g/d; galacto-oligosaccharides, GOS, 6 g/d; sorbitol, 6 g/d; and glucose placebo, 12 g/d), each separated by a standardised washout period...
May 19, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28523219/discovery-and-informing-research-participants-of-incidental-findings-detected-in-brain-magnetic-resonance-imaging-studies-review-and-multi-institutional-study
#15
REVIEW
Kyoko Takashima, Yoshiyuki Takimoto, Eisuke Nakazawa, Yoshinori Hayashi, Atsushi Tsuchiya, Misao Fujita, Akira Akabayashi
BACKGROUND: Brain imaging studies using magnetic resonance imaging (MRI) sometimes reveal incidental findings (IFs) that might be relevant to some of the health issues in research participants. Although professional communities have discussed how to manage these IFs, there is no global consensus on the concrete handling procedures including how to inform participants of IFs. METHODS: First, this study reviewed previous studies for the number of IFs discovered in brain imaging studies using MEDLINE...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28521682/repurposing-of-copper-ii-chelating-drugs-for-the-treatment-of-neurodegenerative-diseases
#16
Valeria Lanza, Danilo Milardi, Giuseppe Di Natale, Giuseppe Pappalardo
BACKGROUND: There is mounting urgency to find new drugs for the treatment of neurodegenerative disorders. A large number of reviews has exhaustively described either the molecular or clinical aspects of neurodegenerative diseases as Alzheimer's (AD) and Parkinson's (PD). Conversely, reports outlining how known drugs in use for other diseases can be also effective as therapeutic agents in neurodegenerative diseases are less reported. This review focuses on the current uses of some copper(II) interacting molecules as potential drug candidates in neurodegeneration...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28520927/preoperative-stratification-of-transsphenoidal-pituitary-surgery-patients-based-on-surgical-urgency
#17
Hasan A Zaidi, Amy J Wang, David J Cote, Timothy R Smith, Daniel Prevedello, Domenico Solari, Paolo Cappabianca, Monica Quiroga, Edward R Laws
BACKGROUND: Currently, there is no prioritization scale available to distinguish those patients with pituitary tumors who require urgent surgical intervention from those who are candidates for elective treatment. OBJECTIVE: To develop a classification system that can help primary care physicians, endocrinologists, neurosurgeons, ancillary support staff, and hospital administrators identify high-priority surgical candidates. METHODS: An expert international panel of clinicians consisting of endocrinologists and neurosurgeons who are involved in the diagnosis and management of sellar disease was convened...
May 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28516158/a-management-algorithm-for-mitomycin-c-induced-cystitis
#18
Amy N Luckenbaugh, Rory M Marks, David C Miller, Alon Z Weizer, John T Stoffel, Jeffrey S Montgomery
Background/Objective: A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Currently, there is no established treatment algorithm for MMC-induced cystitis. Methods: Members of the Urologic Surgery Quality Collaborative (USQC), a group composed of over 160 private and academic urologists, met to discuss the management of patients with cystitis following MMC therapy...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28508455/a-multicenter-real-life-study-of-the-efficacy-of-an-alpha-blocker-with-or-without-anticholinergic-agent-imidafenacin-treatment-in-patients-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-and-storage-symptoms
#19
Seok Cho, Soon-Sun Kwon, Kwang Woo Lee, Tag Keun Yoo, Dong Gil Shin, Soo Woong Kim, Jae Hyun Bae, Hoon Choi, Young Ho Kim
AIMS: To evaluate the efficacy and safety of combination therapy comprising a short-acting anticholinergic, imidafenacin and an alpha-blocker compared with monotherapy with an alpha-blocker only in men with lower urinary tract symptoms (LUTS) and storage symptoms. METHODS: The 12-week, prospective, double-blind, randomised trial enrolled men with LUTS and storage symptom. The inclusion criteria were a total International Prostate Symptom Score (IPSS) ≥12, an IPSS question 4 score ≥2, ≥8 micturitions in 24 hours, and a prostate volume >20 mL...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28507655/how-are-pharmacists-in-ontario-adapting-to-practice-change-results-of-a-qualitative-analysis-using-kotter-s-change-management-model
#20
Beatriz Teixeira, Paul A M Gregory, Zubin Austin
BACKGROUND: The pace of practice change in community pharmacy over the past decade has been significant, yet there is little evidence documenting implementation of change in the profession. METHODS: Kotter's change management model was selected as a theoretical framework for this exploratory qualitative study. Community pharmacists were interviewed using a semistructured protocol based on Kotter's model. Data were analyzed and coded using a constant-comparative iterative method aligned with the stages of change management outlined by Kotter...
May 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
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