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Tbi and edema

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https://www.readbyqxmd.com/read/27901023/rhein-and-rhubarb-similarly-protect-the-blood-brain-barrier-after-experimental-traumatic-brain-injury-via-gp91-phox-subunit-of-nadph-oxidase-ros-erk-mmp-9-signaling-pathway
#1
Yang Wang, Xuegong Fan, Tao Tang, Rong Fan, Chunhu Zhang, Zebing Huang, Weijun Peng, Pingping Gan, Xingui Xiong, Wei Huang, Xi Huang
Oxidative stress chiefly contributes to the disruption of the BBB following traumatic brain injury (TBI). The Chinese herbal medicine rhubarb is a promising antioxidant in treating TBI. Here we performed in vivo and in vitro experiments to determine whether rhubarb and its absorbed bioactive compound protected the BBB after TBI by increasing ZO-1 expression through inhibition of gp91(phox) subunit of NADPH oxidase/ROS/ERK/MMP-9 pathway. Rats were subjected to the controlled cortical impact (CCI) model, and primary rat cortical astrocytes were exposed to scratch-wound model...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894783/comparison-of-speed-vacuum-method-and-heat-drying-method-to-measure-brain-water-content-of-small-brain-samples
#2
Anne Sebastiani, Tobias Hirnet, Antje Jahn-Eimermacher, Serge C Thal
BACKGROUND: A reliable measurement of brain water content (wet-to-dry ratio) is an important prerequisite for conducting research on mechanisms of brain edema formation. The conventionally used oven-drying method suffers from several limitations, especially in small samples. A technically demanding and time-consuming alternative is freeze-drying. NEW METHOD: Centrifugal vacuum concentrators (e.g. SpeedVac/speed-vacuum drying) are a combination of vacuum-drying and centrifugation, used to reduce the boiling temperature...
November 25, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27875293/attenuation-of-blood-brain-barrier-breakdown-and-hyperpermeability-by-calpain-inhibition
#3
Himakarnika Alluri, Marcene Grimsley, Chinchusha Anasooya Shaji, Kevin Paul Varghese, Shenyuan L Zhang, Chander Peddaboina, Bobby Robinson, Madhava R Beeram, Jason H Huang, Binu Tharakan
Blood-brain barrier (BBB) breakdown and the associated microvascular hyperpermeability followed by brain edema is a hallmark feature of several brain pathologies including traumatic brain injuries (TBI). Recent studies indicate that pro-inflammatory cytokine interleukin-1β (IL-1β) that is upregulated following traumatic injuries also promotes BBB dysfunction and hyperpermeability but the underlying mechanisms are not clearly known. The objective of this study was to determine the role of calpains in mediating BBB dysfunction and hyperpermeability and to test the effect of calpain inhibition on the BBB following traumatic insults to the brain...
November 8, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27872704/effects-of-sex-steroid-hormones-on-neuromedin-s-and-neuromedin-u2-receptor-expression-following-experimental-traumatic-brain-injury
#4
Mohammad Khaksari, Fatemeh Maghool, Gholamreza Asadikaram, Zahra Hajializadeh
OBJECTIVES: Neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (TBI). Two of these peptides are including the regulatory peptides neuromedin U (NMU) and neuromedin S (NMS), and their common receptor neuromedin U2 receptor (NMUR2). This study investigates the effects of physiological doses of estradiol and progesterone on brain edema, NMS and NMU as well as NMUR2 expression following TBI...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27869558/polynitroxylated-pegylated-hemoglobin-a-novel-small-volume-therapeutic-for-traumatic-brain-injury-resuscitation-comparison-to-whole-blood-and-dose-response-evaluation
#5
Erik C Brockman, Travis C Jackson, C Edward Dixon, Hulya Bayir, Robert Clark, Vincent A Vagni, Keri L Janesko, Catherine Byrd, Li Ma, Carleton J C Hsia, Patrick M Kochanek
: Resuscitation with polynitroxylated pegylated hemoglobin (PNPH), a PEGylated bovine hemoglobin decorated with nitroxides, eliminated the need for fluid administration, reduced ICP and brain edema, and produced neuroprotection in vitro and in vivo vs. lactated Ringer's (LR) in experimental traumatic brain injury (TBI) plus hemorrhagic shock (HS). HYPOTHESIS: Resuscitation with PNPH will improve acute physiology vs. whole blood after TBI+HS and will be safe and effective across a wide dosage range...
November 21, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27830534/guanosine-protects-against-traumatic-brain-injury-induced-functional-impairments-and-neuronal-loss-by-modulating-excitotoxicity-mitochondrial-dysfunction-and-inflammation
#6
Rogério da Rosa Gerbatin, Gustavo Cassol, Fernando Dobrachinski, Ana Paula O Ferreira, Caroline B Quines, Iuri D Della Pace, Guilherme L Busanello, Jessié M Gutierres, Cristina W Nogueira, Mauro S Oliveira, Félix A Soares, Vera M Morsch, Michele R Fighera, Luiz Fernando F Royes
Traumatic brain injury (TBI) is one of the most common types of brain injuries that cause death or persistent neurological disturbances in survivors. Most of the promising experimental drugs were not effective in clinical trials; therefore, the development of TBI drugs represents a huge unmet need. Guanosine, an endogenous neuroprotective nucleoside, has not been evaluated in TBI to the best of our knowledge. Therefore, the present study evaluated the effect of guanosine on TBI-induced neurological damage. Our findings showed that a single dose of guanosine (7...
November 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27818606/modeling-4d-pathological-changes-by-leveraging-normative-models
#7
Bo Wang, Marcel Prastawa, Andrei Irimia, Avishek Saha, Wei Liu, S Y Matthew Goh, Paul M Vespa, John D Van Horn, Guido Gerig
With the increasing use of efficient multimodal 3D imaging, clinicians are able to access longitudinal imaging to stage pathological diseases, to monitor the efficacy of therapeutic interventions, or to assess and quantify rehabilitation efforts. Analysis of such four-dimensional (4D) image data presenting pathologies, including disappearing and newly appearing lesions, represents a significant challenge due to the presence of complex spatio-temporal changes. Image analysis methods for such 4D image data have to include not only a concept for joint segmentation of 3D datasets to account for inherent correlations of subject-specific repeated scans but also a mechanism to account for large deformations and the destruction and formation of lesions (e...
October 2016: Computer Vision and Image Understanding: CVIU
https://www.readbyqxmd.com/read/27762660/time-dependent-effects-of-arginine-vasopressin-v1-receptor-inhibition-on-secondary-brain-damage-after-traumatic-brain-injury
#8
Sandro M Krieg, Raimund Trabold, Nikolaus Plesnila
Arginine-vasopressin (AVP) V1 receptors are known to mediate brain edema formation after traumatic brain injury (TBI). So far, however, AVP V1 receptors were only inhibited by genetic deletion or prior to trauma. Therefore the current study aimed to determine the therapeutic window of AVP V1 receptors anatomization after TBI. Male C57BL/6 mice (n=7 per group) were subjected to controlled cortical impact (CCI) and 500 ng of a selective peptide V1 receptor antagonist (V1880) were applied by intracerebroventricular injection 5 min, 1, 3, and 6 hours thereafter...
October 20, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27734181/ursolic-acid-ameliorates-early-brain-injury-after-experimental-traumatic-brain-injury-in-mice-by-activating-the-nrf2-pathway
#9
Hui Ding, Handong Wang, Lin Zhu, Wuting Wei
Previous studies have indicated oxidative stress and inflammatory injury as significant contributors to the secondary damage associated with traumatic brain injury (TBI). Ursolic acid (UA) has been demonstrated to exert anti-oxidative and anti-inflammatory effects on cerebral ischemia by activating the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. However, the effects of UA on TBI remain unclear. The aim of this study is to evaluate the potential roles of UA in the activation of the Nrf2 pathway using an experimental TBI model and the underlying mechanism...
October 12, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27698733/role-of-picco-monitoring-for-the-integrated-management-of-neurogenic-pulmonary-edema-following-traumatic-brain-injury-a-case-report-and-literature-review
#10
Xiaoping Lin, Zhijun Xu, Pengfei Wang, Yan Xu, Gensheng Zhang
Neurogenic pulmonary edema (NPE) is occasionally observed in patients with traumatic brain injury (TBI); however, this condition is often underappreciated. NPE is frequently misdiagnosed due to its atypical clinical performance, thus delaying appropriate treatment. A comprehensive management protocol of NPE in patients with TBI has yet to be established. The current study reported the case of a 67-year-old man with severe TBI who was transferred to our intensive care unit (ICU). On day 7 after hospitalization, the patient suddenly suffered tachypnea, tachycardia, systemic hypertension and hypoxemia during lumbar cistern drainage...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27677908/abcc8-single-nucleotide-polymorphisms-are-associated-with-cerebral-edema-in-severe-tbi
#11
Ruchira M Jha, Ava M Puccio, David O Okonkwo, Benjamin E Zusman, Seo-Young Park, Jessica Wallisch, Philip E Empey, Lori A Shutter, Robert S B Clark, Patrick M Kochanek, Yvette P Conley
OBJECTIVE: Cerebral edema (CE) in traumatic brain injury (TBI) is the consequence of multiple underlying mechanisms and is associated with unfavorable outcomes. Genetic variability in these pathways likely explains some of the clinical heterogeneity observed in edema development. A role for sulfonylurea receptor-1 (Sur1) in CE is supported. However, there are no prior studies examining the effect of genetic variability in the Sur1 gene (ABCC8) on the development of CE. We hypothesize that ABCC8 single nucleotide polymorphisms (SNPs) are predictive of CE...
September 27, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27662529/treatment-of-traumatic-brain-injury-with-17%C3%AE-ethinylestradiol-3-sulfate-in-a-rat-model
#12
Harrison Kim, Tao Yu, Betul Cam-Etoz, Thomas van Groen, William J Hubbard, Irshad H Chaudry
OBJECTIVE 17α-ethynylestradiol-3-sulfate (EE-3-SO4) is a highly water-soluble synthetic estrogen that has an extended half-life (∼ 10 hours) over that of naturally occurring estrogen (∼ 10 minutes). In this study, EE-3-SO4 was evaluated in a lateral fluid percussion-induced traumatic brain injury (TBI) model in rats. METHODS A total of 9 groups of Sprague-Dawley rats underwent craniectomy. Twenty-four hours later, lateral fluid percussion was applied to 6 groups of animals to induce TBI; the remaining 3 groups served as sham control groups...
September 23, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27630106/mir-23b-improves-cognitive-impairments-in-traumatic-brain-injury-by-targeting-atg12-mediated-neuronal-autophagy
#13
Liqian Sun, Aihua Liu, Jingbo Zhang, Wenjun Ji, Youxiang Li, Xinjian Yang, Zhongxue Wu, Jian Guo
Dysregulated microRNAs (miRNAs) have been reported to involve in the pathophysiological process of traumatic brain injury (TBI), and modulate autophagy-related genes (ATGs) expression. Our previous studies showed that neuronal autophagy was activated in the injury hippocampus post- TBI and associated with neurological and cognitive impairments. The present study was designed to investigate the possible role of miR-23b in TBI-induced cognitive impairments. We found the overexpression of miR-23b conferred a better neuronprotective effects after TBI by decreasing lesion volume, alleviating brain edema, inhibiting neuron apoptosis and attenuating long-term neurological deficits, and most interestingly, improving cognitive impairments...
September 11, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27602324/aqueous-date-fruit-efficiency-as-preventing-traumatic-brain-deterioration-and-improving-pathological-parameters-after-traumatic-brain-injury-in-male-rats
#14
Hamze Badeli, Nader Shahrokhi, Mahdieosadat KhoshNazar, Majid Asadi-Shekaari, Mohammad Shabani, Hassan Eftekhar Vaghefi, Mohammad Khaksari, Mohsen Basiri
OBJECTIVE: Following traumatic brain injury, disruption of blood-brain-barrier and consequent brain edema are critical events which might lead to increasing intracranial pressure (ICP), and nerve damage. The current study assessed the effects of aqueous date fruit extract (ADFE) on the aforementioned parameters. MATERIALS AND METHODS: In this experimental study, diffused traumatic brain injury (TBI) was generated in adult male rats using Marmarou's method. Experimental groups include two pre-treatment (oral ADFE, 4 and 8 mL/kg for 14 days), vehicle (distilled water, for 14 days) and sham groups...
2016: Cell Journal
https://www.readbyqxmd.com/read/27582726/the-controlled-cortical-impact-model-applications-considerations-for-researchers-and-future-directions
#15
REVIEW
Nicole D Osier, C Edward Dixon
Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that was developed nearly 30 years ago with the goal of creating a testing platform to determine the biomechanical properties of brain tissue exposed to direct mechanical deformation. Initially used to model TBIs produced by automotive crashes, the CCI model rapidly transformed into a standardized technique to study TBI mechanisms and evaluate therapies. CCI is most commonly produced using a device that rapidly accelerates a rod to impact the surgically exposed cortical dural surface...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27581370/astaxanthin-alleviates-cerebral-edema-by-modulating-nkcc1-and-aqp4-expression-after-traumatic-brain-injury-in-mice
#16
Mingkun Zhang, Zhenwen Cui, Hua Cui, Yang Cao, Chunlong Zhong, Yong Wang
BACKGROUND: Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-inflammatory, antitumor, and immunomodulatory activities. Previous studies have demonstrated that astaxanthin displays potential neuroprotective properties for the treatment of central nervous system diseases, such as ischemic brain injury and subarachnoid hemorrhage. This study explored whether astaxanthin is neuroprotective and ameliorates neurological deficits following traumatic brain injury (TBI)...
2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27573472/effect-of-internal-jugular-vein-compression-on-intracranial-hemorrhage-in-a-porcine-controlled-cortical-impact-model
#17
Brian Sindelar, Julian E Bailes, Sydney Ann Sherman, John Desmond Finan, James Stone, John M Lee, Saman Ahmadian, Ying Zhou, Vimal Patel, David Smith
Internal jugular vein (IJV) compression has been shown to reduce axonal injury in pre-clinical traumatic brain injury models and clinical concussion studies. However, this novel approach to prophylactically mitigating traumatic brain injury (TBI) through venous congestion raises concerns of increasing the propensity for hemorrhage and hemorrhagic propagation. This study aims to test the safety of IJV compression in a large animal controlled cortical impact (CCI) injury model and the resultant effects on hemorrhage...
August 29, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27565146/etifoxine-improves-sensorimotor-deficits-and-reduces-glial-activation-neuronal-degeneration-and-neuroinflammation-in-a-rat-model-of-traumatic-brain-injury
#18
Emmanuelle Simon-O'Brien, Delphine Gauthier, Véronique Riban, Marc Verleye
BACKGROUND: Traumatic brain injury (TBI) results in important neurological impairments which occur through a cascade of deleterious physiological events over time. There are currently no effective treatments to prevent these consequences. TBI is followed not only by an inflammatory response but also by a profound reorganization of the GABAergic system and a dysregulation of translocator protein 18 kDa (TSPO). Etifoxine is an anxiolytic compound that belongs to the benzoxazine family...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27554593/-18-f-fdg-pet-combined-with-mri-elucidates-the-pathophysiology-of-traumatic-brain-injury-in-rats
#19
Fiona Brabazon, Colin M Wilson, Dinesh K Shukla, Sanjeev Mathur, Shalini Jaiswal, Sara Bermudez, Kimberly R Byrnes, Reed Selwyn
Non-invasive measurements of brain metabolism using (18)F-fluorodeoxyglucose (FDG) with positron emission tomography (PET) may provide important information about injury severity following traumatic brain injury (TBI). There is growing interest in the potential of combining functional PET imaging with anatomical and functional magnetic resonance imaging (MRI). This study aimed to investigate the effectiveness of combining clinically available FDG-PET with T2 and diffusion MR imaging, with a particular focus on inflammation and the influence of glial alterations after injury...
October 13, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27548472/long-term-anesthetic-dependent-hypoactivity-after-repetitive-mild-traumatic-brain-injuries-in-adolescent-mice
#20
Bridgette D Semple, Raha Sadjadi, Jaclyn Carlson, Yiran Chen, Duan Xu, Donna M Ferriero, Linda J Noble-Haeusslein
Recent evidence supports the hypothesis that repetitive mild traumatic brain injuries (rmTBIs) culminate in neurological impairments and chronic neurodegeneration, which have wide-ranging implications for patient management and return-to-play decisions for athletes. Adolescents show a high prevalence of sports-related head injuries and may be particularly vulnerable to rmTBIs due to ongoing brain maturation. However, it remains unclear whether rmTBIs, below the threshold for acute neuronal injury or symptomology, influence long-term outcomes...
2016: Developmental Neuroscience
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