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Tbi and edema

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https://www.readbyqxmd.com/read/28315576/control-of-lower-extremity-edema-in-patients-with-diabetes-double-blind-randomized-controlled-trial-assessing-the-efficacy-of-mild-compression-diabetic-socks
#1
Stephanie C Wu, Ryan T Crews, Melissa Skratsky, Julia Overstreet, Sai V Yalla, Michelle Winder, Jacquelyn Ortiz, Charles A Andersen
AIMS: Persons with diabetes frequently present with lower extremity (LE) edema; however, compression therapy is generally avoided for fear of compromising arterial circulation in a population with a high prevalence of peripheral arterial disease. This double blind randomized controlled trial (RCT) assessed whether diabetic socks with mild compression could reduce LE edema in patients with diabetes without negatively impacting vascularity. METHODS: Eighty subjects with LE edema and diabetes were randomized to receive either mild-compression knee high diabetic socks (18-25mmHg) or non-compression knee high diabetic socks...
February 27, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28261150/intranasal-administration-of-the-antisecretory-peptide-af-16-reduces-edema-and-improves-cognitive-function-following-diffuse-traumatic-brain-injury-in-the-rat
#2
Fredrik Clausen, Hans-Arne Hansson, Johan Raud, Niklas Marklund
A synthetic peptide with antisecretory activity, antisecretory factor (AF)-16, improves injury-related deficits in water and ion transport and decreases intracranial pressure after experimental cold lesion injury and encephalitis although its role in traumatic brain injury (TBI) is unknown. AF-16 or an inactive reference peptide was administrated intranasally 30 min following midline fluid percussion injury (mFPI; n = 52), a model of diffuse mild-moderate TBI in rats. Sham-injured (n = 14) or naïve (n = 24) animals were used as controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28219400/alleviation-of-secondary-brain-injury-posttraumatic-inflammation-and-brain-edema-formation-by-inhibition-of-factor-xiia
#3
Sarah Hopp, Marc W Nolte, Christian Stetter, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weissenberger
BACKGROUND: Traumatic brain injury (TBI) is a devastating neurological condition and a frequent cause of permanent disability. Posttraumatic inflammation and brain edema formation, two pathological key events contributing to secondary brain injury, are mediated by the contact-kinin system. Activation of this pathway in the plasma is triggered by activated factor XII. Hence, we set out to study in detail the influence of activated factor XII on the abovementioned pathophysiological features of TBI...
February 20, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28170180/therapeutic-prospective-of-infused-allogenic-cultured-mesenchymal-stem-cells-in-traumatic-brain-injury-mice-a-longitudinal-proton-magnetic-resonance-spectroscopy-assessment
#4
Sushanta Kumar Mishra, Poonam Rana, Subash Khushu, Gurudutta Gangenahalli
Improved therapeutic assessment of experimental traumatic brain injury (TBI), using mesenchymal stem cells (MSCs), would immensely benefit its therapeutic management. Neurometabolite patterns at injury site, measured with proton magnetic resonance spectroscopy (1H-MRS) after MSCs transplantation, may serve as a bio-indicator of the recovery mechanism. This study used in vivo magnetic resonance imaging and 1H-MRS to evaluate the therapeutic prospects of implanted MSCs at injury site in experimental mice longitudinally up to 21 days...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28157110/connexin40-correlates-with-oxidative-stress-in-brains-of-traumatic-brain-injury-rats
#5
Wei Chen, Yijun Guo, Wenjin Yang, Ping Zheng, Jinsong Zeng, Wusong Tong
BACKGROUND: Oxidative stress is an important factor in the pathophysiologic changes after traumatic brain injury (TBI). Connexin43 (Cx43) was reported to contribute to cerebral damage. However, the impacts of Cx40 have not been investigated in detail. OBJECTIVE: In the present study, we hypothesized that Cx40 was involved in oxidative stress-induced brain injury after TBI. METHODS: The controlled cortical impact (CCI) model was introduced to Wistar rats as a TBI model...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28101166/hsp70-inducer-17-allylamino-demethoxygeldanamycin-provides-neuroprotection-via-anti-inflammatory-effects-in-a-rat-model-of-traumatic-brain-injury
#6
Youquan Gu, Jun Chen, Tianhong Wang, Chaoning Zhou, Zhaodong Liu, Lanhua Ma
Traumatic brain injury (TBI) is the predominant cause of mortality in young adults and children living in China. TBI induces inflammatory responses; in addition, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 are important pro-inflammatory cytokines. Considering the observation that Hsp-70 overexpression can exert neuroprotection, identifying a drug that is able to induce the upregulation of Hsp70 has the potential to be a promising therapy for the treatment of neurological diseases. Thus, the present study assessed the clinical effectiveness of an anticancer drug and Hsp70 activator, 17-allylamino-demethoxygeldanamycin (17-AAG), to evaluate its potential as a treatment for patients with TBI...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28094295/loss-of-pafr-prevents-neuroinflammation-and-brain-dysfunction-after-traumatic-brain-injury
#7
Xiang-Jie Yin, Zhen-Yan Chen, Xiao-Na Zhu, Jin-Jia Hu
Traumatic brain injury (TBI) is a principal cause of death and disability worldwide, which is a major public health problem. Death caused by TBI accounts for a third of all damage related illnesses, which 75% TBI occurred in low and middle income countries. With the increasing use of motor vehicles, the incidence of TBI has been at a high level. The abnormal brain functions of TBI patients often show the acute and long-term neurological dysfunction, which mainly associated with the pathological process of malignant brain edema and neuroinflammation in the brain...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091411/protective-effects-of-calpain-inhibition-on-neurovascular-unit-injury-through-downregulating-nuclear-factor-%C3%AE%C2%BAb-related-inflammation-during-traumatic-brain-injury-in-mice
#8
Xiao-Gang Tao, Jing-Hua Shi, Shu-Yu Hao, Xue-Tao Chen, Bai-Yun Liu
BACKGROUND: In addition to neurons, all components of the neurovascular unit (NVU), such as glial, endothelial, and basal membranes, are destroyed during traumatic brain injury (TBI). Previous studies have shown that excessive stimulation of calpain is crucial for cerebral injury after traumatic insult. The objective of this study was to investigate whether calpain activation participated in NVU disruption and edema formation in a mouse model of controlled cortical impact (CCI). METHODS: One hundred and eight mice were divided into three groups: the sham group, the control group, and the MDL28170 group...
January 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28075214/intralipid-vehicle-does-not-interfere-with-the-efficacy-of-progesterone-in-attenuating-edema-following-traumatic-brain-injury
#9
Bushra Wali, Donald G Stein, Iqbal Sayeed
The recent disappointing results of phase III trials for progesterone (PROG) in traumatic brain injury (TBI) have triggered speculation about reasons for the negative outcomes. One confounding factor may have been the vehicle used to administer PROG. Virtually all of the many pre-clinical experiments informing the clinical trials and reporting beneficial PROG effects used more soluble 2-hydroxypropyl-b-cyclodextrin as a vehicle given intraperitoneally or subcutaneously rather than a lipid formulation given intravenously (IV)...
February 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28054290/treatment-of-hyponatremia-in-patients-with-acute-neurological-injury
#10
Theresa Human, Aaron M Cook, Brian Anger, Kathleen Bledsoe, Amber Castle, David Deen, Haley Gibbs, Christine Lesch, Norah Liang, Karen McAllen, Christopher Morrison, Dennis Parker, A Shaun Rowe, Denise Rhoney, Kiranpal Sangha, Elena Santayana, Scott Taylor, Eljim Tesoro, Gretchen Brophy
BACKGROUND: Little data exist regarding the practice of sodium management in acute neurologically injured patients. This study describes the practice variations, thresholds for treatment, and effectiveness of treatment in this population. METHODS: This retrospective, multicenter, observational study identified 400 ICU patients, from 17 centers, admitted for ≥48 h with subarachnoid hemorrhage (SAH), traumatic brain injury (TBI), intraparenchymal hemorrhage, or intracranial tumors between January 1, 2011 and July 31, 2012...
January 4, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/27995513/progesterone-provides-the-pleiotropic-neuroprotective-effect-on-traumatic-brain-injury-through-the-nrf2-are-signaling-pathway
#11
Mei Zhang, Jianyue Wu, Haojun Ding, Wentian Wu, Guomin Xiao
OBJECTIVE: This study was to investigate the role of Nrf2/ARE signaling pathway in the pleiotropic neuroprotective effect of progesterone (PROG) on traumatic brain injury (TBI). METHODS: The Nrf2-knockout (Nrf2-/-) and C57 mice were respectively subjected to a lateral cortical impact injury caused by a free-falling object and randomly divided into three groups: sham-operated, trauma, and trauma + PROG treatment group. The PROG treatment group was given PROG (32 mg/kg of body weight, intraperitoneal injection) immediately after injury...
April 2017: Neurocritical Care
https://www.readbyqxmd.com/read/27959885/potassium-aspartate-attenuates-brain-injury-induced-by-controlled-cortical-impact-in-rats-through-increasing-adenosine-triphosphate-atp-levels-na-k-atpase-activity-and-reducing-brain-edema
#12
Yi Gu, Jie Zhang, Yumei Zhao, Yujin Su, Yazhuo Zhang
BACKGROUND Potassium aspartate (PA), as an electrolyte supplement, is widely used in clinical practice. In our previous study, we found PA had neuroprotective effects against apoptosis after cerebral ischemia/reperfusion in rats. In this study, we examine whether PA has protective effects on traumatic brain injury (TBI). MATERIAL AND METHODS TBI was induced by controlled cortical impact (CCI) in rats. Vehicle treatment (control) or PA treatment was administered intraperitoneally at 30 minutes after CCI. The modified neurological severity score (mNSS) and cortical lesion volume were examined...
December 13, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27930615/effects-of-aquaporin-4-knockdown-on-brain-edema-of-the-uninjured-side-after-traumatic-brain-injury-in-rats
#13
Jian-Qiang Chen, Cheng-Cheng Zhang, Sheng-Nan Jiang, Hong Lu, Wei Wang
BACKGROUND Traumatic brain injury (TBI) induces edema on the uninjured side (i.e., contralateral brain tissue; CBT). We evaluated the role of AQP4 in CBT edema formation following TBI. MATERIAL AND METHODS Mild or severe TBI was induced using a controlled cortical impact model in rats, immediately followed by intraventricular siRNA infusions. The effects of AQP4 siRNA on CBT edema were assessed at up to 168 h. RESULTS Mild or severe TBI induced different patterns of CBT edema. Furthermore, following mild TBI, brain water content (BWC) was increased at 72 h thereafter and AQP4 expression was increased after 168 h, relative to non-injured rats (i...
December 8, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27926982/trpv4-channels-mediate-na-k-cl-co-transporter-induced-brain-edema-after-traumatic-brain-injury
#14
Kwok-Tung Lu, Tai-Chun Huang, Ya-Hsin Tsai, Yi-Ling Yang
Na(+) -K(+) -2Cl(-) co-transporter (NKCC1) plays an important role in traumatic brain injury (TBI)-induced brain edema via the mitogen-activated protein kinases (MAPK) cascade. The transient receptor potential vanilloid type 4 (TRPV4) channel participates in neurogenic inflammation, pain transmission and edema. In this study, we investigated the relationship between NKCC1 and TRPV4 and the related signaling pathways in TBI-induced brain edema and neuronal damage. TBI was induced by the calibrated weight-drop device...
December 7, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27924525/a-three-day-consecutive-fingolimod-administration-improves-neurological-functions-and-modulates-multiple-immune-responses-of-cci-mice
#15
Chuang Gao, Yu Qian, Jinhao Huang, Dong Wang, Wanqiang Su, Peng Wang, Linyue Guo, Wei Quan, Shuo An, Jianning Zhang, Rongcai Jiang
Excessive inflammation after traumatic brain injury (TBI) is a major cause of secondary TBI. Though several inflammatory biomarkers have been postulated as the risk factors of TBI, there has not been any comprehensive description of them. Fingolimod, a new kind of immunomodulatory agent which can diminish various kinds of inflammatory responses, has shown additional therapeutic effects in the treatment of intracranial cerebral hematoma (ICH), ischemia, spinal cord injury (SCI), and many other CNS disorders...
December 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27919684/neuroprotective-effects-of-mir-27a-against-traumatic-brain-injury-via-suppressing-foxo3a-mediated-neuronal-autophagy
#16
Liqian Sun, Manman Zhao, Yan Wang, Aihua Liu, Ming Lv, Youxiang Li, Xinjian Yang, Zhongxue Wu
MicroRNA-27a (miR-27a) has been reported to be a brain-specific miRNA and aberrantly expressed in the brain suffered from traumatic brain injury (TBI). The present study is designed to investigate the potential role and molecular mechanism of miR-27a in the pathogenesis of TBI. The level of miR-27a in brain was manipulated by intracerebroventricular injection of lentiviral-encoding miR-27a before TBI induction. Real-time PCR was used to detected miR-27a and Forkhead box O3a (FoxO3a) levels in the hippocampus...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27916727/posttraumatic-administration-of-a-sub-anesthetic-dose-of-ketamine-exerts-neuroprotection-via-attenuating-inflammation-and-autophagy
#17
C-Q Wang, Y Ye, F Chen, W-C Han, J-M Sun, X Lu, R Guo, K Cao, M-J Zheng, L-C Liao
As a complex disease, traumatic brain injury (TBI) can result in long-term psychiatric changes and sensorimotor and cognitive impairments. The TBI-induced loss of memory and long-term cognitive dysfunction are related to mechanistic factors including an increased inflammatory response, autophagy, edema, and ischemia. Many published studies have offered evidence for the neuroprotective effects and anti-inflammatory properties of ketamine for TBI patients. Nonetheless, there is a limited understanding of the accurate mechanism that underlies the potential neuroprotective effects of ketamine...
December 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27916377/tetrahydrocurcumin-provides-neuroprotection-in-rats-after-traumatic-brain-injury-autophagy-and-the-pi3k-akt-pathways-as-a-potential-mechanism
#18
Yongyue Gao, Jie Li, Lingyun Wu, Chenhui Zhou, Qiang Wang, Xiang Li, Mengliang Zhou, Handong Wang
BACKGROUND: Tetrahydrocurcumin provides neuroprotection in multiple neurologic disorders by modulating oxidative stress, inflammatory responses, and autophagy. However, in traumatic brain injury (TBI), it is unclear whether a beneficial effect of tetrahydrocurcumin exists. In this study, we hypothesized that administration of tetrahydrocurcumin provides neuroprotection in a rat model of TBI. MATERIAL AND METHODS: Behavioral studies were performed by recording and analyzing beam-walking scores...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27901023/rhein-and-rhubarb-similarly-protect-the-blood-brain-barrier-after-experimental-traumatic-brain-injury-via-gp91-phox-subunit-of-nadph-oxidase-ros-erk-mmp-9-signaling-pathway
#19
Yang Wang, Xuegong Fan, Tao Tang, Rong Fan, Chunhu Zhang, Zebing Huang, Weijun Peng, Pingping Gan, Xingui Xiong, Wei Huang, Xi Huang
Oxidative stress chiefly contributes to the disruption of the BBB following traumatic brain injury (TBI). The Chinese herbal medicine rhubarb is a promising antioxidant in treating TBI. Here we performed in vivo and in vitro experiments to determine whether rhubarb and its absorbed bioactive compound protected the BBB after TBI by increasing ZO-1 expression through inhibition of gp91(phox) subunit of NADPH oxidase/ROS/ERK/MMP-9 pathway. Rats were subjected to the controlled cortical impact (CCI) model, and primary rat cortical astrocytes were exposed to scratch-wound model...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894783/comparison-of-speed-vacuum-method-and-heat-drying-method-to-measure-brain-water-content-of-small-brain-samples
#20
Anne Sebastiani, Tobias Hirnet, Antje Jahn-Eimermacher, Serge C Thal
BACKGROUND: A reliable measurement of brain water content (wet-to-dry ratio) is an important prerequisite for conducting research on mechanisms of brain edema formation. The conventionally used oven-drying method suffers from several limitations, especially in small samples. A technically demanding and time-consuming alternative is freeze-drying. NEW METHOD: Centrifugal vacuum concentrators (e.g. SpeedVac/speed-vacuum drying) are a combination of vacuum-drying and centrifugation, used to reduce the boiling temperature...
January 30, 2017: Journal of Neuroscience Methods
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