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https://www.readbyqxmd.com/read/29165084/advances-on-automatic-speech-analysis-for-early-detection-of-alzheimer-disease-a-non-linear-multi-task-approach
#1
K Lopez-de-Ipina, U Martinez-de-Lizarduy, P M Calvo, Jiri Mekyska, B Beitia, N Barroso, A Estanga, M Tainta, M Ecay-Torres
Nowadays proper detection of cognitive impairment has become a challenge for the scientific community. Alzheimer's Disease (AD), the most common cause of dementia, has a high prevalence that is increasing at a fast pace towards epidemic level. In the not-so-distant future this fact could have a dramatic social and economic impact. In this scenario, an early and accurate diagnosis of AD could help to decrease its effects on patients, relatives and society. Over the last decades there have been useful advances not only in classic assessment techniques, but also in novel non-invasive screening methodologies...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29163107/the-complexity-of-h-wave-amplitude-fluctuations-and-their-bilateral-cross-covariance-are-modified-according-to-the-previous-fitness-history-of-young-subjects-under-track-training
#2
Maria E Ceballos-Villegas, Juan J Saldaña Mena, Ana L Gutierrez Lozano, Francisco J Sepúlveda-Cañamar, Nayeli Huidobro, Elias Manjarrez, Joel Lomeli
The Hoffmann reflex (H-wave) is produced by alpha-motoneuron activation in the spinal cord. A feature of this electromyography response is that it exhibits fluctuations in amplitude even during repetitive stimulation with the same intensity of current. We herein explore the hypothesis that physical training induces plastic changes in the motor system. Such changes are evaluated with the fractal dimension (FD) analysis of the H-wave amplitude-fluctuations (H-wave FD) and the cross-covariance (CCV) between the bilateral H-wave amplitudes...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29162967/lubricin-a-principal-modulator-of-the-psychoneuroendocrine-osteoimmune-interactome-implications-for-novel-treatments-of-osteoarthritic-pathologies
#3
Allen Khakshooy, Nicole Balenton, Francesco Chiappelli
Lubricin is a synovial glycoprotein that contributes to joint lubrication. We propose the hypothesis that lubricin is a key modulator of the psychoneuroendocrine-osteoimmune interactome, with important clinical relevance for osteoarthritic pathologies. We consider a variety of neuroendocrine-immune factors, including inflammatory cytokines and chemokines that may contribute to the modulation of lubricin in rheumatic complications. Based on our preliminary immunocytochemistry and fractal analysis data, and in the context of translational research of modern healthcare, we propose that molecular lubricin gene expression modification by means of the novel CRISPR/Cas system be considered for osteoarthritic therapies...
2017: Bioinformation
https://www.readbyqxmd.com/read/29162445/the-neuromorphological-caudate-putaminal-clustering-of-neostriate-interneurons-kohonen-self-organizing-maps-and-supervised-artificial-neural-networks-with-multivariate-analysis
#4
Ivan Grbatinić, Nebojša Milošević, Bojana Krstonošić
AIMS: The objective of this study is to investigate the possibility of the neuromorphotopological clustering of neostriate interneurons (NSIN) and their consequent classification into caudate (CIN) and putaminal neuron type (PIN), according to the nuclear localization of the neurons. It tends to discover whether these two topological neuron types are morphologically different. MATERIAL AND METHODS: The binary images of adult human NSIN are used for the purposes of the analysis...
November 18, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29158980/north-atlantic-oscillation-drives-the-annual-occurrence-of-an-isolated-peripheral-population-of-the-brown-seaweed-fucus-guiryi-in-the-western-mediterranean-sea
#5
Ignacio J Melero-Jiménez, A Enrique Salvo, José C Báez, Elena Bañares-España, Andreas Reul, Antonio Flores-Moya
The canopy-forming, intertidal brown (Phaeophyceae) seaweed Fucus guiryi is distributed along the cold-temperate and warm-temperate coasts of Europe and North Africa. Curiously, an isolated population develops at Punta Calaburras (Alboran Sea, Western Mediterranean) but thalli are not present in midsummer every year, unlike the closest (ca. 80 km), perennial populations at the Strait of Gibraltar. The persistence of the alga at Punta Calaburras could be due to the growth of resilient, microscopic stages as well as the arrival of few-celled stages originating from neighbouring localities, and transported by the permanent Atlantic Jet flowing from the Atlantic Ocean into the Mediterranean...
2017: PeerJ
https://www.readbyqxmd.com/read/29154534/a-route-towards-ultra-sensitive-layered-carbon-based-piezoresistive-sensors-through-hierarchical-contact-design
#6
Xiaoshuang Duan, Jiangjiang Luo, Yanbo Yao, Tao Liu
Ultrahigh sensitive piezoresistive sensors at small deformation are highly desired in many applications. Here we propose a hierarchical contact design concept and implement it through direct laser writing technique for fabricating the layered carbon piezoresistive sensors with ultrahigh sensitivity. The sensors with unprecedented gauge factors (~ 5000 - 10,000) at small deformation ( < 0.1 %) were successfully fabricated and demonstrated for their use in sensing both static and high-frequency (20 - 30 kHz) dynamic mechanical loads...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29149297/dna-knots-occur-in-intracellular-chromatin
#7
Antonio Valdés, Joana Segura, Sílvia Dyson, Belén Martínez-García, Joaquim Roca
In vivo DNA molecules are narrowly folded within chromatin fibers and self-interacting chromatin domains. Therefore, intra-molecular DNA entanglements (knots) might occur via DNA strand passage activity of topoisomerase II. Here, we assessed the presence of such DNA knots in a variety of yeast circular minichromosomes. We found that small steady state fractions of DNA knots are common in intracellular chromatin. These knots occur irrespective of DNA replication and cell proliferation, though their abundance is reduced during DNA transcription...
November 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29147146/relationships-between-short-and-fast-brain-timescales
#8
Eva Déli, Arturo Tozzi, James F Peters
Brain electric activity exhibits two important features: oscillations with different timescales, characterized by diverse functional and psychological outcomes, and a temporal power law distribution. In order to further investigate the relationships between low- and high- frequency spikes in the brain, we used a variant of the Borsuk-Ulam theorem which states that, when we assess the nervous activity as embedded in a sphere equipped with a fractal dimension, we achieve two antipodal points with similar features (the slow and fast, scale-free oscillations)...
December 2017: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29144144/structural-emergence-in-particle-dispersions
#9
Andrew Mulderig, Gregory Beaucage, Karsten Vogtt, Hanqiu Jiang, Yan Jin, Lisa Clapp, Donald Henderson
Particle dispersions, such as pigment-based inks, comprise weakly bound, milled nanoparticles. The properties of these pigments depend on both their chemical composition, as well as a rather complex structural hierarchy, which emerges from these dispersions. The emergence of structure under semi-dilute conditions is related to the structure of the dilute particles, the particle spacing (mesh size), processing history, and the interaction potential. Kinetic simulations could predict such emergence using these input parameters...
November 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29141776/evaluation-of-a-new-ensemble-learning-framework-for-mass-classification-in-mammograms
#10
Omid Rahmani Seryasat, Javad Haddadnia
BACKGROUND: Mammography is the most common screening method for diagnosis of breast cancer. MATERIALS AND METHODS: In this study, a computer-aided system for diagnosis of benignity and malignity of the masses was implemented in mammogram images. In the computer aided diagnosis system, we first reduce the noise in the mammograms using an effective noise removal technique. After the noise removal, the mass in the region of interest must be segmented and this segmentation is done using a deformable model...
May 22, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29140370/mandibular-bone-structure-analysis-using-cone-beam-computed-tomography-vs-primary-implant-stability-an-ex-vivo-study
#11
Ruben Pauwels, Somchai Sessirisombat, Soontra Panmekiate
PURPOSE: To evaluate the relationship between mandibular bone structure parameters measured on preimplant cone beam computed tomography (CBCT) images and primary implant stability. MATERIALS AND METHODS: Twenty-one hemimandibles were scanned on the 3D Accuitomo 170 CBCT. Next, an implant was placed in each hemimandible, after which insertion torque and implant stability quotient (ISQ) measurements were acquired. The following measurements were performed on the preimplant CBCT scans: bone surface, bone volume, fractal dimension, connectivity, trabecular thickness and spacing, and skeleton analysis...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29132124/variations-of-moisture-and-organics-in-activated-sludge-during-fe-0-s2o8-2-conditioning-horizontal-electro-dewatering-process
#12
Haoxuan Li, Yili Wang, Huaili Zheng
The feasibility of using Fe(0)/S2O8(2-) conditioning (zero valence iron (ZVI)/persulfate (ps)) integrated with horizontal electro-dewatering (HED) to improve the dewaterability of activated sludge (AS) was evaluated. The removal and migration of free and bound water in the ZVI/ps-HED process were determined, along with the organic matter migration between the solid and liquid phases of AS biosolids. Results showed that the optimum conditioning dosages were determined as 0.35 g ZVI/g dry solids (DS) and 0.15 g ps/g DS on the basis of capillary suction time variation...
November 6, 2017: Water Research
https://www.readbyqxmd.com/read/29131278/fractal-and-stereological-analyses-of-insulin-induced-rat-exocrine-pancreas-remodeling
#13
Mila Pajevic, Marija Aleksic, Igor Golic, Milica Markelic, Vesna Otasevic, Aleksandra Jankovic, Ana Stancic, Bato Korac, Aleksandra Korac
The effect of insulin on the endocrine pancreas has been the subject of extensive study, but quantitative morphometric investigations of the exocrine pancreas are scarce. This study was therefore undertaken to investigate the effect of acute and chronic insulin administration (two doses, 0.4 IU and 4 IU) on the morphology of rat pancreas acini. Semi-fine sections stained with methylene blue and basic fuchsine or hematoxylin- and eosin-stained 5-micrometer thick paraffin sections were used for fractal and stereological analysis of exocrine acini...
November 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29123129/effect-of-substrate-symmetry-on-the-dendrite-morphology-of-mos2-film-synthesized-by-cvd
#14
Di Wu, Tai Min, Jian Zhou, Chen Li, Guobin Ma, Gaotian Lu, Minggang Xia, Zhengbin Gu
In van der Waals epitaxial growth, the substrate plays a particularly important role in the crystal morphology. Here, we synthesized MoS2 by chemical vapour deposition on silicon carbide (SiC). The obtained MoS2 dendritic crystals show six-fold symmetry, which are different from the conventional triangular shapes on SiO2 substrate and from those with three-fold symmetry on SrTiO3 substrate. Interestingly, these MoS2 dendritic crystals on SiC exhibit an average fractal dimension 1.76, which is slightly larger than the classical Diffusion-limited-Aggregation fractal dimension 1...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119540/discrimination-of-stroke-related-mild-cognitive-impairment-and-vascular-dementia-using-eeg-signal-analysis
#15
Noor Kamal Al-Qazzaz, Sawal Hamid Bin Mohd Ali, Siti Anom Ahmad, Mohd Shabiul Islam, Javier Escudero
Stroke survivors are more prone to developing cognitive impairment and dementia. Dementia detection is a challenge for supporting personalized healthcare. This study analyzes the electroencephalogram (EEG) background activity of 5 vascular dementia (VaD) patients, 15 stroke-related patients with mild cognitive impairment (MCI), and 15 control healthy subjects during a working memory (WM) task. The objective of this study is twofold. First, it aims to enhance the discrimination of VaD, stroke-related MCI patients, and control subjects using fuzzy neighborhood preserving analysis with QR-decomposition (FNPAQR); second, it aims to extract and investigate the spectral features that characterize the post-stroke dementia patients compared to the control subjects...
November 8, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29118692/statistical-image-properties-in-large-subsets-of-traditional-art-bad-art-and-abstract-art
#16
Christoph Redies, Anselm Brachmann
Several statistical image properties have been associated with large subsets of traditional visual artworks. Here, we investigate some of these properties in three categories of art that differ in artistic claim and prestige: (1) Traditional art of different cultural origin from established museums and art collections (oil paintings and graphic art of Western provenance, Islamic book illustration and Chinese paintings), (2) Bad Art from two museums that collect contemporary artworks of lesser importance (© Museum Of Bad Art [MOBA], Somerville, and Official Bad Art Museum of Art [OBAMA], Seattle), and (3) twentieth century abstract art of Western provenance from two prestigious museums (Tate Gallery and Kunstsammlung Nordrhein-Westfalen)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29112091/macro-and-microvascular-parameters-following-toxic-shock-syndrome
#17
Katherine Yh Chen, Ling-Jun Li, Tien Y Wong, Carol Y Cheung, Nigel Curtis, Michael Cheung, David P Burgner
Whether individuals who had toxic shock syndrome (TSS) in childhood have differences in macro- and retinal microvascular parameters indicative of increased cardiovascular risk is unknown. We found no evidence of adverse macrovascular changes in 22 TSS participants compared to 60 control participants. Microvascular comparisons showed a reduction in retinal total fractal dimension which has been associated with cardiovascular risk factors in children.
November 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29111587/multifractal-approaches-of-the-ring-tensile-rupture-patterns-of-dried-laver-porphyra-as-affected-by-the-relative-humidity
#18
Hwabin Jung, Won Byong Yoon
The effect of water activity (aw ) or the relative humidity (RH) on the tensile rupture properties of dried laver (DL) associated with structures formed with phycocolloids was investigated. The morphological characteristics of tensile ruptured DL samples at various relative humidities were evaluated by multifractal analysis. The RH of the microclimate was controlled from 10% to 90% at 25 °C using supersaturated salt solutions. The sorption isotherm of DL was experimentally obtained and quantitatively analyzed using mathematical models...
November 7, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29110182/new-complexity-measures-reveal-that-topographic-loops-of-human-alpha-phase-potentials-are-more-complex-in-drowsy-than-in-wake
#19
Aleksandar Kalauzi, Aleksandra Vuckovic, Tijana Bojić
A number of measures, stemming from nonlinear dynamics, exist to estimate complexity of biomedical objects. In most cases they are appropriate, but sometimes unconventional measures, more suited for specific objects, are needed to perform the task. In our present work, we propose three new complexity measures to quantify complexity of topographic closed loops of alpha carrier frequency phase potentials (CFPP) of healthy humans in wake and drowsy states. EEG of ten adult individuals was recorded in both states, using a 14-channel montage...
November 7, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29107953/radiotherapy-and-chemotherapy-change-vessel-tree-geometry-and-metastatic-spread-in-a-small-cell-lung-cancer-xenograft-mouse-tumor-model
#20
Thorsten Frenzel, Bertin Hoffmann, Rüdiger Schmitz, Anja Bethge, Udo Schumacher, Gero Wedemann
BACKGROUND: Tumor vasculature is critical for tumor growth, formation of distant metastases and efficiency of radio- and chemotherapy treatments. However, how the vasculature itself is affected during cancer treatment regarding to the metastatic behavior has not been thoroughly investigated. Therefore, the aim of this study was to analyze the influence of hypofractionated radiotherapy and cisplatin chemotherapy on vessel tree geometry and metastasis formation in a small cell lung cancer xenograft mouse tumor model to investigate the spread of malignant cells during different treatments modalities...
2017: PloS One
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