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Alter-G Treadmill

Matthijs T W Veltmeijer, Dineke Veeneman, Coen C C W Bongers, Mihai G Netea, Jos W van der Meer, Thijs M H Eijsvogels, Maria T E Hopman
PURPOSE: Exercise increases core body temperature (TC) due to metabolic heat production. However, the exercise-induced release of inflammatory cytokines including interleukin-6 may also contribute to the rise in TC by increasing the hypothalamic temperature setpoint. We aimed to investigate whether the exercise-induced increase in TC is partly caused by an altered hypothalamic temperature setpoint. METHODS: 15 healthy, active male subjects aged 36±14 years were recruited...
September 26, 2016: International Journal of Sports Physiology and Performance
Matthew F Moran, Brendan J Rickert, Beau K Greer
CONTEXT: Treadmills that unload runners via a differential air pressure bladder (DAP; e.g. AlterG Anti-Gravity Treadmill) are commonly used to reduce effective body weight in a clinical setting, however, the relationship between the level of unloading and tibial stress is currently unknown. OBJECTIVE: To determine the relationship between tibial impact acceleration and level of body weight (BW) unloading during running. DESIGN: Cross-sectional...
August 24, 2016: Journal of Sport Rehabilitation
Michael J Ormsbee, Katherine A Gorman, Elizabeth A Miller, Daniel A Baur, Lisa A Eckel, Robert J Contreras, Lynn B Panton, Maria T Spicer
The timing of morning endurance competition may limit proper pre-race fueling and resulting performance. A nighttime, pre-sleep nutritional strategy could be an alternative method to target the metabolic and hydrating needs of the early morning athlete without compromising sleep or gastrointestinal comfort during exercise. Therefore, the purpose of this investigation was to examine the acute effects of pre-sleep chocolate milk (CM) ingestion on next-morning running performance, metabolism, and hydration status...
July 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Maarten R Prins, Peter van der Wurff, Onno G Meijer, Sjoerd M Bruijn, Jaap H van Dieën
INTRODUCTION: Patients with chronic low back pain (CLBP) often demonstrate altered timing of thorax rotations in the transverse plane during gait. Increased axial trunk stiffness has been claimed to cause this movement pattern. OBJECTIVES: The objective of this study was to assess whether axial trunk stiffness is increased in gait in CLBP patients. METHODS: 15 CLBP patients and 15 healthy controls walked on a treadmill that imposed rotational perturbations in the transverse plane...
2016: PloS One
Ariana Dela Cruz, Marc D Grynpas, Jane Mitchell
Intermittent parathyroid hormone (iPTH) treatment and mechanical loading are osteoanabolic stimuli that are partially mediated through actions on G protein-coupled receptors (GPCRs). GPCR signaling can be altered by heterotrimeric G protein Gα subunits levels, which can therefore lead to altered responses to such stimuli. Previous studies have suggested that enhanced signaling through the Gαq/11 pathway inhibits the osteoanabolic actions of PTH. The influence of Gαq/11 signaling on mechanotransduction, however, has not been reported in vivo...
October 2016: Calcified Tissue International
Y S Nout-Lomas, K M Page, H G Kang, M E Aanstoos, H M Greene
BACKGROUND: There is poor agreement between observers of equine neurological gait abnormalities using the modified Mayhew grading scale. OBJECTIVES: To stimulate a dose-dependent ataxia in horses through xylazine administration and identify quantifiable relevant gait parameters. STUDY DESIGN: Balanced, randomised, 2-way crossover design. METHODS: Eight horses were assessed before and after administration of xylazine (low dose and high dose)...
June 14, 2016: Equine Veterinary Journal
Ciaran M Fairman, Kristina L Kendall, Brandonn S Harris, Kenneth J Crandall, Jim McMillan
Breast Cancer survivors can experience a myriad of physical and psychological benefits as a result of regular exercise. This study aimed to build on previous research using lower impact exercise programs by using an antigravity (Alter-G(®)) treadmill to administer cardiovascular training. The purpose of this study was to determine the effectiveness a physical activity program, including an Alter-G(®) treadmill, for improving physiological and psychosocial measures in female breast cancer survivors. A 14-week intervention using an AB-AB study design was employed...
2016: International Journal of Exercise Science
Michelle S Dotzert, Michael R Murray, Matthew W McDonald, T Dylan Olver, Thomas J Velenosi, Anzel Hennop, Earl G Noble, Brad L Urquhart, C W James Melling
The etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects approximately 20% of T1D patients. Intramyocellular lipids (IMCL) have been identified as a mechanism of insulin resistance. We examined skeletal muscle of T1D rats to determine if alterations in lipid metabolism were evident and whether aerobic exercise training improves IMCL and insulin resistance. To do so, 48 male Sprague-Dawley rats were divided into control (C), sedentary diabetes (D) and diabetes exercise (DX) groups...
2016: Scientific Reports
Fausto A Panizzolo, Ignacio Galiana, Alan T Asbeck, Christopher Siviy, Kai Schmidt, Kenneth G Holt, Conor J Walsh
BACKGROUND: Carrying load alters normal walking, imposes additional stress to the musculoskeletal system, and results in an increase in energy consumption and a consequent earlier onset of fatigue. This phenomenon is largely due to increased work requirements in lower extremity joints, in turn requiring higher muscle activation. The aim of this work was to assess the biomechanical and physiological effects of a multi-joint soft exosuit that applies assistive torques to the biological hip and ankle joints during loaded walking...
2016: Journal of Neuroengineering and Rehabilitation
Abdullah F Alghannam, Dawid Jedrzejewski, James Bilzon, Dylan Thompson, Kostas Tsintzas, James A Betts
We examined whether carbohydrate-protein ingestion influences muscle glycogen metabolism during short-term recovery from exhaustive treadmill running and subsequent exercise. Six endurance-trained individuals underwent two trials in a randomised double-blind design, each involving an initial run-to-exhaustion at 70% VO2max (Run-1) followed by 4-h recovery (REC) and subsequent run-to-exhaustion at 70% VO2max (Run-2). Carbohydrate-protein (CHO-P; 0.8 g carbohydrate•kg body mass [BM(-1)]•h(-1) plus 0.4 g protein•kg BM(-1)•h(-1)) or isocaloric carbohydrate (CHO; 1...
August 24, 2016: International Journal of Sport Nutrition and Exercise Metabolism
Daniel Hamacher, Karsten Hollander, Astrid Zech
BACKGROUND: Considering that proprioceptive deficits seem to be responsible for chronic ankle instability, the precise control of ankle angles during running may be impaired. Thus, the aim of the study was to evaluate the influence of chronic ankle instability on intra-individual variability of ankle kinematics during running. METHODS: Lower extremity running gait kinematics of 12 recreational athletes with chronic ankle instability (mean age: 24 years, SD: 3 years; strides analyzed: 40...
March 2016: Clinical Biomechanics
Milad Azad, Neda Khaledi, Mehdi Hedayati
Skeletal muscle is a highly elastic tissue which can respond to various functional demands by altering fiber-type composition. Exercise affects muscle fiber phenotype. One of the transcription factors that induce fiber-type transition is forkhead box O1 (FOXO1). Since eccentric contraction considered an essential part of exercise, so we are interested to see the effects of eccentric exercise (acute/chronic) on FOXO1 as an important factor of fiber-type transition in rat skeletal muscles. Twenty-four Sprague-Dawley rats (190-235g) were divided to 3 groups of 8 rats: 1) chronic eccentric exercise (CEE), 2) acute eccentric exercise (AEE), and 3) control (C)...
June 15, 2016: Gene
Timothy P Just, Darren S DeLorey
Exercise training (ET) increases sympathetic vasoconstrictor responsiveness and enhances contraction-mediated inhibition of sympathetic vasoconstriction (i.e., sympatholysis) through a nitric oxide (NO)-dependent mechanism. Changes in α2-adrenoreceptor vasoconstriction mediate a portion of these training adaptations, however the contribution of other postsynaptic receptors remains to be determined. Therefore, the purpose of this study was to investigate the effect of ET on α1-adrenoreceptor-mediated vasoconstriction in resting and contracting muscle...
February 2016: Physiological Reports
Matthew F Moran, Brendan J Rickert, Beau K Greer
CONTEXT: Treadmills that unload runners via a differential air pressure bladder (DAP; e.g. AlterG Anti-Gravity Treadmill) are commonly used to reduce effective body weight in a clinical setting, however, the relationship between the level of unloading and tibial stress is currently unknown. OBJECTIVE: To determine the relationship between tibial impact acceleration and level of body weight (BW) unloading during running. DESIGN: Cross-sectional...
January 18, 2016: Journal of Sport Rehabilitation
A Steimers, M Vafiadou, G Koukourakis, D Geraskin, P Neary, M Kohl-Bareis
We used spatially resolved near-infrared spectroscopy (SRS-NIRS) to assess calf and thigh muscle oxygenation during running on a motor-driven treadmill. Two protocols were used: An incremental speed protocol was performed in 5-min stages, while a pacing paradigm modulated the step frequency (2.3 Hz [SLow]; 3.3 Hz [SHigh]) during a constant velocity for 2 min each. A SRS-NIRS broadband system was used to measure total haemoglobin concentration and oxygen saturation (SO2). An accelerometer was placed on the hip joints to measure limb acceleration through the experiment...
2016: Advances in Experimental Medicine and Biology
Catherine L Stables, David S Auerbach, Steven E Whitesall, Louis G D'Alecy, Eva L Feldman
AIMS: Cardiac autonomic dysfunction is a serious complication of diabetes. One consequence is disruption of the normal beat-to-beat regulation of heart rate (HR), i.e. HR variability (HRV). However, our understanding of the disease process has been limited by inconsistent HR/HRV data from previous animal studies. We hypothesized that differences in the method of measurement, time of day, and level of stress account for the differing results across studies. Thus, our aim was to systematically assess HR and HRV in two common diabetic mouse models...
January 2016: Autonomic Neuroscience: Basic & Clinical
Kait Clark, Simon Rushton
Recently, Ayaz et al. (2013) reported a remarkable finding: surround suppression, as measured by V1 activation in mice, is substantially reduced during locomotion (running in place). Does low-level visual processing change in humans when they are walking? Such a change would recast our understanding of the relationship between vision and action and might explain previously observed effects of walking on motion perception (e.g., Durgin, 2009). To assess how the findings of Ayaz et al. extend to behavioural effects in human vision, we tested participants during locomotion and used an established behavioural measure of perceptual suppression based on Tadin et al...
2015: Journal of Vision
B Stocks, J A Betts, K McGawley
This study investigated carbohydrate ingestion of varied doses and frequencies during a simulated cross-country skiing time trial. Ten men and three women (age: 30 ± 7 years; V ˙ O 2 m a x : 59.6 ± 5.7 mL/kg/min) completed four, 30-km classic technique roller skiing time trials on a treadmill. A 1:1 maltodextrin-fructose carbohydrate solution was provided at high (2.4 g/min; HC) and moderate (1.2 g/min; MC) ingestion rates, each at high (six feeds; HF) and low (two feeds; LF) frequencies. In the LF trials, blood glucose was elevated following carbohydrate ingestion (at 4 and 19 km) but was reduced at 14 and 29 km compared with HF strategies (P ≤ 0...
September 2016: Scandinavian Journal of Medicine & Science in Sports
Rachel L Lenhart, Colin R Smith, Michael F Vignos, Jarred Kaiser, Bryan C Heiderscheit, Darryl G Thelen
Interventions used to treat patellofemoral pain in runners are often designed to alter patellofemoral mechanics. This study used a computational model to investigate the influence of two interventions, step rate manipulation and quadriceps strengthening, on patellofemoral contact pressures during running. Running mechanics were analyzed using a lower extremity musculoskeletal model that included a knee with six degree-of-freedom tibiofemoral and patellofemoral joints. An elastic foundation model was used to compute articular contact pressures...
August 20, 2015: Journal of Biomechanics
Maria Angela M Q Carreira, André B Nogueira, Felipe M Pena, Marcio G Kiuchi, Ronaldo C Rodrigues, Rodrigo R Rodrigues, Jorge P S Matos, Jocemir R Lugon
OBJECTIVE: To evaluate the ability of different parameters of exercise treadmill test to detect autonomic dysfunction in hemodialysis patients. METHODS: Cross-sectional study involving hemodialysis patients and a control group. Clinical examination, blood sampling, echocardiogram, 24-hour Holter, and exercise treadmill test were performed. A ramp treadmill protocol symptom-limited with active recovery was employed. RESULTS: Forty-one hemodialysis patients and 41 controls concluded the study...
2015: PloS One
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