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Norihiro Honda, Katsunori Ishii, Yoshinaga Kajimoto, Toshihiko Kuroiwa, Kunio Awazu
The optical properties of human brain tumor tissues, including glioblastoma, meningioma, oligodendroglioma, and metastasis, that were classified into "strong," "vague," and "unobservable" fluorescence by a neurosurgeon were measured and compared. The optical properties of the tissues were measured with a double integrating sphere and the inverse Monte Carlo technique from 350 to 1000 nm. Using reasons of ex-vivo measurement, the optical properties at around 420 nm were potentially affected by the hemoglobin content in tissues...
July 2018: Journal of Biomedical Optics
Alessandro Agnarelli, Marco Natali, Mercedes Garcia-Gil, Rossana Pesi, Maria Grazia Tozzi, Chiara Ippolito, Nunzia Bernardini, Robert Vignali, Renata Batistoni, Anna Maria Bianucci, Silvia Marracci
The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma U343 and pancreatic carcinoma MIA PaCa-2 cells. Human dermal fibroblasts (HDF) were used as non-cancer cells. We show that berberine differentially affects cell viability, displaying a higher cytotoxicity on the two cancer cell lines than on HDF. Berberine also affects cell cycle progression, senescence, caspase-3 activity, autophagy and migration in a cell-specific manner...
July 13, 2018: Scientific Reports
Dongsic Choi, Laura Montermini, Dae-Kyum Kim, Brian Meehan, Frederick P Roth, Janusz Rak
Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). EGFRvIII impacts both cell-intrinsic and non-cell autonomous aspects of GBM progression, including cell invasion, angiogenesis and modulation of the tumor microenvironment. This is, at least in part, attributable to the release and intercellular trafficking of extracellular vesicles (EVs), heterogeneous membrane structures containing multiple bioactive macromolecules...
July 13, 2018: Molecular & Cellular Proteomics: MCP
Mei Shao, Wenyun Liu, Yu Wang
Glioblastoma (GBM) is the most common and aggressive brain tumor with the poor clinical outcome. LncRNAs (Long non-coding RNAs) play an important role in the occurrence and development of glioblastoma. We aimed to explore the role that lncRNAs play in regulating glioblastoma and the pathways they are enriched in. The expression data of a total of 516 GBM samples were downloaded from TCGA (The Cancer Genome Atlas). We identified the differentially expressed lncRNAs between cancer and normal tissues and performed annotation of differentially expressed lncRNAs to figure out the functions and pathways they were enriched in...
October 2018: Cancer Genetics
Niamh Mc Namee, Lorraine O'Driscoll
Extracellular vesicles (EVs) including exosomes, microvesicles, oncosomes, and microparticles have been associated with communicating anti-cancer drug-resistance. The in vitro, pre-clinical in vivo and patients' data linking EVs to drug-resistance (and the specific drugs involved) in breast cancer, prostate cancer, lung cancer, ovarian cancer, haematological malignancies, colorectal cancer, gastric cancer, pancreatic cancer, glioblastoma, neuroblastoma, melanoma, kidney cancer and osteosarcoma. Details of the mechanisms by which the resistance seems to be occurring (e...
July 9, 2018: Biochimica et Biophysica Acta
Farina Hanif, Kahkashan Perveen, Saima M Malhi, Huma Jawed, Shabana U Simjee
Glioblastoma Multiforme (GBM) is the most malignant and invasive tumor of the CNS. Although temozolomide (TMZ) has improved the survival, long-lasting responses have not been reported. Therefore, there is a need to develop improved treatments, one of which might be newly identified drugs which can be used in combination therapy with low doses of standard drugs. Verapamil (VP) a known antihypertensive drug has been shown to enhance the activity of bis-chloroethylnitrosourea (BCNU), a drug used to treat GBM. Since, TMZ has replaced BCNU as the standard GBM chemotherapy; therefore, we aimed to study in vitro interaction of VP and TMZ against GBM...
July 9, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Oliver D Mrowczynski, Brad E Zacharia, James R Connor
Exosomes are 20-100 nm cellular derived vesicles that upon discovery, were thought to be a form of cellular recycling of intracellular contents. More recently, these vesicles are under investigation for their purported significant roles in intercellular communication in both healthy and diseased states. Herein, we focus on the secretion of exosomes associated with glioblastoma, as most exosome studies on brain tumors have been performed in this tumor type. However, we included exosomes secreted from other forms of brain tumors for comparison as available...
July 9, 2018: Progress in Neurobiology
Kenneth Maiese
No abstract text is available yet for this article.
July 11, 2018: Current Neurovascular Research
Mihaela Aldea, Monica Potara, Olga Soritau, Ioan Stefan Florian, Adrian Florea, Timea Nagy-Simon, Valentina Pileczki, Ioana Brie, Dana Maniu, Gabriel Kacso
PURPOSE: Glioblastoma is a rapidly evolving lethal disease mainly due to its highly chemo- and radioresistant glioblastoma stem cells (GSCs). Herein, we tested if chitosan-capped gold nanoparticles (Chit-GNPs) may overcome the limitations of drug concentrations by increased cell internalization in GSCs and if such GNPs could enhance the response to irradiation. METHODS: Chitosan was used for Chit-GNP synthesis as a reducing and stabilizing agent. Chit-GNPs were characterized by spectroscopy, dark field, transmission electron microscopy and zeta potential measurements...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
C H Suh, H S Kim, S C Jung, C G Choi, S J Kim
BACKGROUND: O6-methylguanine methyltransferase ( MGMT ) promoter methylation status has been reported as a prognostic biomarker in clinical trials. PURPOSE: Our aim was to systematically evaluate imaging features of MGMT promoter methylated glioblastoma and to determine the diagnostic performance of MR imaging for prediction of MGMT promoter methylation in patients with newly diagnosed glioblastoma. DATA SOURCES: A computerized search of Ovid MEDLINE and EMBASE up to February 27, 2018, was conducted...
July 12, 2018: AJNR. American Journal of Neuroradiology
Jiao Wang, Qian Wang, Fangfang Zhou, Jie Li, Qian Li, Hong Zhou, Shiman Li, Sujuan Ma, Tieqiao Wen
BACKGROUND: Glioblastoma is one of the most malignant brain cancer, thus, establishing an effective therapy is paramount. Our previous results indicate that dendritic cell-derived factor (DCF1) is an attractive candidate for therapy against Glioblastoma, since its overexpression in Glioblastoma U251 cells leads to apoptosis. However, the delivery approach limits its clinical application, in this paper, we expressed TAT-DCF1 fusion protein in E.coli in order to surmount its current delivery problems...
June 25, 2018: Neuropeptides
Hao Xu, Shangchen Xu, Rui Zhang, Tao Xin, Qi Pang
Purpose: SIL1 is a ubiquitous protein localized to the endoplasmic reticulum and functions as a cochaperone of BiP. Previous studies have shown that function loss of SIL1 is often associated with neurological diseases, such as Marinesco-Sjögren Syndrome. However, no studies have investigated the function of SIL1 in tumors. In this study we aim to reveal functions of SIL1 and the underlying mechanisms in glioma. Materials and methods: First, by searching on Gene Expression Profiling Interactive Analysis, we examined SIL1 expression and prognostic value in glioblastoma multiforme (GBM) and brain lower grade glioma (LGG)...
2018: OncoTargets and Therapy
Ross W Walton, Michael C Brown, Matthew T Sacco, Matthias Gromeier
We are pursuing cancer immunotherapy with neuro-attenuated recombinant poliovirus, PVSRIPO. PVSRIPO is the live attenuated type 1 (Sabin) poliovirus vaccine carrying a heterologous internal ribosomal entry site (IRES) of human rhinovirus type 2 (HRV2). Intratumoral infusion of PVSRIPO is showing promise in the therapy of recurrent WHO grade IV malignant glioma (glioblastoma), a notoriously treatment-refractory cancer with dismal prognosis. PVSRIPO exhibits profound cytotoxicity in infected neoplastic cells expressing the poliovirus receptor CD155...
July 11, 2018: Journal of Virology
Magdalena Delgado, Timothy C Chambers
We recently reported that primary acute lymphoblastic leukemia (ALL) cells are susceptible to the microtubule depolymerizing agent vincristine (VCR) in G1 phase. This finding prompted testing another G1 phase-active compound, palbociclib (PCB), a highly selective inhibitor of cyclin-dependent kinases 4/6 (CDK4/6), alone and in combination with VCR. PCB used alone caused G1 arrest in ALL cells with no effect on cell viability, and similar results were obtained for the retinoblastoma (RB)-proficient T98G glioblastoma cell line...
July 11, 2018: Cell Cycle
Zhiyuan Qian, Yuping Li, Jiawei Ma, Yanping Xue, Yujun Xi, Lei Hong, Xiaoxiao Dai, Yongsheng Zhang, Xiaoyan Ji, Yanming Chen, Minfeng Sheng, Yujing Sheng, Lin Yang, Jiachi Liu, Xingliang Dai, Jia Shi, Tao Xie, Jun Dong
Nucleolar and spindle-associated protein (NUSAP1) is a microtubule and chromatin-binding protein that stabilizes microtubules to prevent depolymerization, maintains spindle integrity. NUSAP1 could cross-link spindles into aster-like structures, networks and fibers. It has also been found to play roles in progression of several cancers. However, the potential correlation between NUSAP1 and clinical outcome in patients with glioblastoma multiforme (GBM) remains largely unknown. In the current study, we demonstrated that NUSAP1 was significantly up-regulated in GBM tissues compared with adult non-tumor brain tissues both in a validated cohort and a TCGA cohort...
July 11, 2018: Journal of Neuro-oncology
Cornelia Wenger, Pedro Miranda, Ricardo Salvador, Axel Thielscher, Zeev Bomzon, Moshe Giladi, Maciej M Mrugala, Anders R Korshoej
Tumor Treating Fields (TTFields) are a cancer treatment modality that uses alternating electric fields of intermediate frequency (~100-500 kHz) and low intensity (1-3 V/cm) to disrupt cell division. TTFields are delivered by transducer arrays placed on the skin close to the tumor and act regionally and non-invasively to inhibit tumor growth. TTFields therapy is FDA approved for the treatment of glioblastoma multiforme, the most common and aggressive primary human brain cancer. Clinical trials testing the safety and efficacy of TTFields for other solid tumor types are underway...
February 13, 2018: IEEE Reviews in Biomedical Engineering
Ahmad Chaddad, Paul Daniel, Christian Desrosiers, Matthew Toews, Bassam Abdulkarim
This paper presents a novel set of image texture features, generalizing standard grey-level co-occurrence matrices (GLCM) to multi-modal image data through joint intensity matrices (JIMs). These are used to predict the survival of glioblastoma multiforme (GBM) patients from multi-modal MRI data. The scans of 73 GBM patients from the Cancer Imaging Archive are used in our study. Necrosis, active tumor and edema/invasion sub-regions of GBM phenotypes are segmented using the co-registration of contrast enhanced T1-weighted (CET1) images and its corresponding fluid-attenuated inversion recovery (FLAIR) images...
April 9, 2018: IEEE Journal of Biomedical and Health Informatics
Shanyue Sun, Guangying Du, Jiang Xue, Jinbo Ma, Minmin Ge, Hongbo Wang, Jingwei Tian
Indoleamine 2,3-dioxygenase (IDO), which is highly expressed in human glioblastoma and involved in tumor immune escape and resistance to chemotherapy, is clinically correlated with tumor progression and poor clinical outcomes, and is a promising therapeutic target for glioblastoma. IDO inhibitors are marginally efficacious as single-agents; therefore, combination with other therapies holds promise for cancer therapy. The aim of this study was to investigate the anti-tumor effects and mechanisms of the IDO inhibitor PCC0208009 in combination with temozolomide...
January 2018: International Journal of Immunopathology and Pharmacology
Shuo Shi, Min Zhang, Rui Guo, Ying Miao, Biao Li
Bone marrow mesenchymal stem cells (BMSCs) have been used for systemic delivery of therapeutic genes to solid tumors. However, the optimal treatment time post-BMSCs implantation and the assessment of the long-term fate of therapeutic BMSCs post-tumor treatment are critical if such promising therapies are to be translated into clinical practice. Here, we have developed an efficient BMSCs based therapeutic strategy that simultaneously allows killing of tumor cells, inhibiting of tumor angiogenesis and assessment and eradication of implanted BMSCs after treatment of glioblastoma...
July 11, 2018: Human Gene Therapy
Cheng-Wei Lu, Dan-Dan Zhou, Tian Xie, Ji-Long Hao, Om Prakash Pant, Cheng-Bo Lu, Xiu-Fen Liu
The cancers are the leading cause of disease-related deaths worldwide with a high risk of morbidity and mortality. Long noncoding RNAs (lncRNAs) play a critical role in a wide range of biological processes, including tumorigenesis. HOXA11-AS (NCRNA00076), the antisense strands of HOXA11 gene, was initially revealed in a mouse embryonic cDNA library in 2009 and it was a fairly novel lncRNA. This review summarized the advanced research progression concerning the expression and role of HOXA11-AS in different human malignancies...
July 10, 2018: Cancer Medicine
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