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REVIEW
Cornelius Heyer
No abstract text is available yet for this article.
April 2024: MMW Fortschritte der Medizin
#2
Rohini Pawar, Abhay Munde, Apeksha Surse, Pratik Ghoderao, Pranjal Limbagaonkar, Rutuja Chawardol
BACKGROUND: The objective of this report was to highlight the importance of using a dental operating microscope (DOM) to locate supernumerary canals and diagnose variations in root canals using cone-beam computed tomographic (CBCT) images. CASE PRESENTATION: A 23-year-old male patient had reported with a pain for 1 months and was referred to evaluate symptomatic apical periodontitis for lower right first permanent molar. Root canal therapy was proposed and conducted with the use of DOM and CBCT...
February 2024: Journal of Pharmacy & Bioallied Sciences
#3
Jayakrishna Niari, Nagesh Waghmare, Kalyan S Munde
No abstract text is available yet for this article.
April 2024: European Heart Journal. Case Reports
#4
JOURNAL ARTICLE
Katharina Radunsky, Agnes Boltz, Veronika Pia Vécsei-Marlovits
Virus-related illnesses are a common phenomenon, especially in the colder months of the year. They usually manifest with cough, cold, and other flu-associated symptoms. They affect people of all ages and genders. In recent years, also virus-associated ocular symptoms have been documented repeatedly. One of the viruses known to cause these is the Coxsackievirus A, which causes hand, foot, and mouth disease. Three cases of these virus-associated macular changes are described below. In all three cases, the symptoms occurred unilaterally and with little time delay to the virus-typical general changes...
April 3, 2024: Wiener Medizinische Wochenschrift
#5
JOURNAL ARTICLE
Ann Schirin Mirsanaye, Saskia Hoffmann, Melanie Weisser, Andreas Mund, Blanca Lopez Mendez, Dimitris Typas, Johannes van den Boom, Bente Benedict, Ivo A Hendriks, Michael Lund Nielsen, Hemmo Meyer, Julien P Duxin, Guillermo Montoya, Niels Mailand
The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ubiquitylated client proteins via multiple cofactors, most of which interact with the p97 N-domain. Here, we discover that FAM104A, a protein of unknown function also named VCF1 (VCP/p97 nuclear Cofactor Family member 1), acts as a p97 cofactor in human cells. Detailed structure-function studies reveal that VCF1 directly binds p97 via a conserved α-helical motif that recognizes the p97 N-domain with unusually high affinity, exceeding that of other cofactors...
March 19, 2024: Nature Communications
#6
JOURNAL ARTICLE
Neetu Tanwar, Rupal Ojha, Soumya Aggarwal, Vijay Kumar Prajapati, Manoj Munde
Protein-protein interactions (PPI) have emerged as valuable targets in medicinal chemistry due to their key roles in important biological processes. The modulation of PPI by small peptides offers an excellent opportunity to develop drugs against human diseases. Here, we exploited the knowledge of the binding interface of the IgG-protein G complex (PDB:1FCC) for designing peptides that can inhibit these complexes. Herein, we have designed several closely related peptides, and the comparison of results from experiments and computational studies indicated that all the peptides bind close to the expected binding site on IgG and the complexes are stable...
March 17, 2024: European Biophysics Journal: EBJ
#7
JOURNAL ARTICLE
Anne Geweniger, Michael Barth, Anneke Haddad, Henriette Högl, Shrabon Insan, Annette Mund, Thorsten Langer
BACKGROUND: Children with special healthcare needs (CSHCN) require more support than the average of their peers. Support systems for CSHCN were particularly affected by pandemic control measures. Perceived social support is a resource for health and wellbeing for CSHCN and their families. Associations of social support, mental health and socioeconomic status (SES) have been described. This study aims to (1) assess perceived social support in families with and without CSHCN; (2) describe structure and types of social networks of families with and without CSHCN; and (3) explore associations between perceived social support, disease complexity, child and caregiver mental health, and SES...
2024: Frontiers in Public Health
#8
JOURNAL ARTICLE
Istvan Grexa, Zsanett Zsófia Iván, Ede Migh, Ferenc Kovács, Hella A Bolck, Xiang Zheng, Andreas Mund, Nikita Moshkov, Vivien Miczán, Krisztian Koos, Peter Horvath
Numerous imaging techniques are available for observing and interrogating biological samples, and several of them can be used consecutively to enable correlative analysis of different image modalities with varying resolutions and the inclusion of structural or molecular information. Achieving accurate registration of multimodal images is essential for the correlative analysis process, but it remains a challenging computer vision task with no widely accepted solution. Moreover, supervised registration methods require annotated data produced by experts, which is limited...
January 22, 2024: Briefings in Bioinformatics
#9
JOURNAL ARTICLE
Abby S Kazley, Christine Andresen, Angela Mund, Karen A Wager, Clint Blankenship, Rick Segal
For many decades, academic cheating has been prevalent across many institutions and majors. This problem has been exacerbated by new technology that has increased opportunities for students to access and use information dishonestly. There is fear amongst faculty that dishonesty in the academic world could negatively impact professionals in their future careers. The greater prevalence of cheating may be related to students misunderstanding what constitutes cheating. To better understand students' perceptions of cheating, a group of faculty surveyed students across 11 academic programs at a college of health professions using a slightly modified version of a validated tool via an online platform...
2024: Journal of Allied Health
#10
Jae-Hyun Yang, Motoshi Hayano, Patrick T Griffin, João A Amorim, Michael S Bonkowski, John K Apostolides, Elias L Salfati, Marco Blanchette, Elizabeth M Munding, Mital Bhakta, Yap Ching Chew, Wei Guo, Xiaojing Yang, Sun Maybury-Lewis, Xiao Tian, Jaime M Ross, Giuseppe Coppotelli, Margarita V Meer, Ryan Rogers-Hammond, Daniel L Vera, Yuancheng Ryan Lu, Jeffrey W Pippin, Michael L Creswell, Zhixun Dou, Caiyue Xu, Sarah J Mitchell, Abhirup Das, Brendan L O'Connell, Sachin Thakur, Alice E Kane, Qiao Su, Yasuaki Mohri, Emi K Nishimura, Laura Schaevitz, Neha Garg, Ana-Maria Balta, Meghan A Rego, Meredith Gregory-Ksander, Tatjana C Jakobs, Lei Zhong, Hiroko Wakimoto, Jihad El Andari, Dirk Grimm, Raul Mostoslavsky, Amy J Wagers, Kazuo Tsubota, Stephen J Bonasera, Carlos M Palmeira, Jonathan G Seidman, Christine E Seidman, Norman S Wolf, Jill A Kreiling, John M Sedivy, George F Murphy, Richard E Green, Benjamin A Garcia, Shelley L Berger, Philipp Oberdoerffer, Stuart J Shankland, Vadim N Gladyshev, Bruce R Ksander, Andreas R Pfenning, Luis A Rajman, David A Sinclair
No abstract text is available yet for this article.
February 29, 2024: Cell
#11
JOURNAL ARTICLE
Jingshu Wei, Georg von Arx, Zexin Fan, Andreas Ibrom, Martina Mund, Alexander Knohl, Richard L Peters, Flurin Babst
The fraction of photosynthetically assimilated carbon that trees allocate to long-lasting woody biomass pools (biomass production efficiency - BPE), is a key metric of the forest carbon balance. Its apparent simplicity belies the complex interplay between underlying processes of photosynthesis, respiration, litter and fruit production, and tree growth that respond differently to climate variability. Whereas the magnitude of BPE has been routinely quantified in ecological studies, its temporal dynamics and responses to extreme events such as drought remain less well understood...
February 6, 2024: Science of the Total Environment
#12
JOURNAL ARTICLE
Stefan Nickel, Demet Dingoyan, David Cebulla, Henriette Högl, Annette Mund, Birgit Fuchs, Kathrin Jackel-Neusser, Christopher Kofahl
Use of support and relief services for parents of children in need of care: Results of the FamBer observational study Abstract: Background: Parents of children in need of care in Germany can fall back on a variety of relief and support services. So far, however, there has been a lack of systematic studies and quantitative data on the use of such offers at the individual level of parents and other legal guardians. Aim: The study on the compatibility of care and work for parents with a child in need of care (FamBer; funding: Federal Ministry for Family Affairs, Senior Citizens, Women and Youth, Germany) examines the knowledge of relief and support services, their use and the perceived benefits of these offers...
January 31, 2024: Pflege
#13
JOURNAL ARTICLE
Somnath C Dhawale, Ajay V Munde, Balaji B Mulik, Raviraj P Dighole, Sanjio S Zade, Bhaskar R Sathe
Development of highly efficient electrocatalysts for treating urea-rich wastewater is an important problem in environmental management and energy production. In this work, an iron-nickel alloy (Fe-Ni alloy) was synthesized via soft-template cetyltrimethylammonium bromide (CTAB)-assisted precipitation using low-temperature calcination. The as-synthesized nanoalloy was characterized by X-ray diffraction (XRD), which revealed the formation of a face-centered cubic (FCC) structure of the Fe-Ni alloy; field emission-scanning electron microscopic (FE-SEM) analysis revealed the spherical shape of the Fe-Ni alloy; high-resolution transmission electron microscopy (HR-TEM) revealed the average size to be ∼33...
January 24, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
#14
JOURNAL ARTICLE
Ajinkya Bandebuche, Kishor Munde, Sudhir Sharan
We present a rare case of open lateral condyle Hoffa's fracture with concurrent patellar intra-articular dislocation, quadriceps rupture and posterior cruciate ligament (PCL) avulsion. The early adolescent male sustained these injuries in a road traffic accident. Diagnostic evaluation and a multidisciplinary approach guided treatment decisions. The patient underwent single-stage open reduction and internal fixation for the lateral condyle Hoffa's fracture and quadriceps tendon repair, while conservative management was chosen for the PCL avulsion...
January 10, 2024: BMJ Case Reports
#15
JOURNAL ARTICLE
Soraya Naimy, Julie B K Sølberg, Dorota E Kuczek, Marianne Bengtson Løvendorf, Michael Bzorek, Thomas Litman, Andreas Mund, Lise Mette Rahbek Gjerdrum, Rachael A Clark, Matthias Mann, Beatrice Dyring-Andersen
A substantial part of cutaneous malignant melanomas develops from benign nevi. However, the precise molecular events driving the transformation from benign to malignant melanoma are not well understood. We used laser microdissection and mass spectrometry to analyze the proteomes of melanoma subtypes, including superficial spreading melanomas (SSM, n=17), nodular melanomas (NM, n=17), and acral melanomas (AM, n=15). Furthermore, we compared the proteomes of nevi cells and melanoma cells within the same specimens (nevus-associated melanoma (NAM, n=14))...
January 5, 2024: Journal of Investigative Dermatology
#16
JOURNAL ARTICLE
Sourabrata Chakraborty, Shivangi Shukla, Mahima Rastogi, Sai Sarbani Mund, Anupam Chowdhury, Chandrachur Mukherjee, Khageswar Sahu, Shovan Kumar Majumder
Antimicrobial wound dressings play a crucial role in treatment of wound infections. However, existing commercial options fall short due to antibiotic resistance and the limited spectrum of activity of newly emerging antimicrobials against bacteria that are frequently encountered in wound infections. Antimicrobial photodynamic therapy (aPDT) is very promising alternative therapeutic approach against antibiotic resistant microbes such as methicillin resistant Staphylococcus aureus (MRSA). However, delivery of the photosensitizer (PS) homogeneously to the wound site is a challenge...
January 5, 2024: Biomedical Materials
#17
JOURNAL ARTICLE
Philipp Linke, Natalie Munding, Esther Kimmle, Stefan Kaufmann, Kentaro Hayashi, Masaki Nakahata, Yoshinori Takashima, Masaki Sano, Martin Bastmeyer, Thomas Holstein, Sascha Dietrich, Carsten Müller-Tidow, Akira Harada, Anthony D Ho, Motomu Tanaka
Stem cells are regulated not only by biochemical signals but also by biophysical properties of extracellular matrix (ECM). The ECM is constantly monitored and remodeled because the fate of stem cells can be misdirected when the mechanical interaction between cells and ECM is imbalanced. We fabricated a well-defined ECM model for bone marrow-derived human mesenchymal stem cells (hMSCs) based on supramolecular hydrogels containing reversible host-guest crosslinks. The stiffness (Young's modulus E) of the hydrogels can be switched reversibly by altering the concentration of non-cytotoxic, free guest molecules dissolved in the culture medium...
December 20, 2023: Advanced Healthcare Materials
#18
JOURNAL ARTICLE
Jon-Emile S Kenny, Ross Prager, Philippe Rola, Garett McCulloch, Sarah Atwi, Chelsea E Munding, Joseph K Eibl, Korbin Haycock
(1) Background: The inspiratory collapse of the inferior vena cava (IVC), a non-invasive surrogate for right atrial pressure, is often used to predict whether a patient will augment stroke volume (SV) in response to a preload challenge. There is a correlation between changing stroke volume (SV∆ ) and corrected flow time of the common carotid artery (ccFT∆ ). (2) Objective: We studied the relationship between IVC collapsibility and ccFT∆ in healthy volunteers during preload challenges. (3) Methods: A prospective, observational, pilot study in euvolemic, healthy volunteers with no cardiovascular history was undertaken in a local physiology lab...
December 3, 2023: Diagnostics
#19
Sanjay K Rai, Tej P Gupta, Prashant Rajauria, Rohan Satish Munde
INTRODUCTION: Heel pain is one of the most common painful conditions of the foot. There are many causes of heel pain, which are usually associated with calcaneal spurs. Hence, it becomes imperative to diagnose and treat them effectively. The development of calcaneal spur is somewhat not well known but is often said to be developed from inflamed plantar fascia. Heel being weight-bearing part of the body, it is very painful something and adversely affects the activity of daily living. Calcaneal spurs are fibrocartilaginous triangular projections from an insertional area of the plantar fascia...
November 2023: Journal of Orthopaedic Case Reports
#20
JOURNAL ARTICLE
Jasmine Bezboruah, Devendra Mayurdhwaj Sanke, Ajay Vinayakrao Munde, Palak Trilochand Bhattad, Himadri Shekhar Karmakar, Sanjio S Zade
Visible light-driven photoelectrochemical (PEC) urea oxidation using inorganic/organic nano-heterostructure (NH) photoanodes is an attractive method for hydrogen (H2 ) production. In this article, inorganic/organic NHs (TiO2 /PDIEH) consisting of a N , N -bis(2-ethylhexyl)perylene-3,4,9,10-tetracarboxylic diimide (PDIEH) thin layer over TiO2 nanorods (NRs) were fabricated for the PEC urea oxidation reaction (UOR). In these NHs, a PDIEH layer was anchored on TiO2 NR arrays using the spin-coating technique, which is beneficial for the uniform deposition of PDIEH on TiO2 NRs...
November 21, 2023: Nanoscale advances
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