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https://www.readbyqxmd.com/read/29410106/thermodynamic-and-conformational-analysis-of-the-interaction-between-antibody-binding-proteins-and-igg
#1
Neetu Tanwar, Manoj Munde
Studying interaction of IgG with bacterial proteins such as proA (Protein A) and proG is essential for development in the areas of drug discovery and biotechnology. Some solution studies in the past have hinted at the possibility of variable binding ratios for IgG with proA and proG. Since earlier crystallographic studies focussed mostly on monomeric complexes, the knowledge about the binding interfaces and protein conformational changes involved in multimeric complexes is scarce. In this paper, we observed that single proA molecule was able to bind to three IgG molecules (1:3, proA:IgG) in ITC accentuating the presence of conformational flexibility in proA, corroborated also by CD results...
January 31, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29324078/what-an-evidence-based-guideline-for-fatigue-risk-management-means-for-us-statements-from-stakeholders
#2
J Brent Myers, R Keith Wages, Dennis Rowe, Chris Nollette, Michael Touchstone, John Sinclair, Edward L Mund, Justin M Eberly, John D Montes, Richard J Sherlock, Laura K Barger, Sean P A Drummond, Indira Gurubhagavatula
No abstract text is available yet for this article.
January 11, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29207717/heterotopic-prostate-at-autopsy-an-unusual-mass-at-the-dome-of-the-urinary-bladder
#3
Shital Munde, Gwendolyn Fernandes, Priyanka Phadnis
Heterotopic prostate in the dome of the urinary bladder is extremely rare and difficult to diagnose. It is often mistaken for neoplastic masses and histopathological examination is warranted for diagnosis. We report an autopsy case of an ectopic prostate at the dome of the bladder which mimicked a neoplasm on gross pathology.
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29150363/development-of-a-3-french-dual-frequency-intravascular-ultrasound-catheter
#4
Chelsea E Munding, Emmanuel Chérin, Isaac Jourard, Jill J Weyers, David E Goertz, Brian K Courtney, F Stuart Foster
Coronary plaque morphology, including plaque size and fibrous cap thickness, is thought to contribute to the risk of plaque rupture and future cardiac events. Dual-frequency intravascular ultrasound has been proposed as a possible technique to visualize both large-scale features and superficial detail of coronary plaque; however, it has not been found to be feasible within the constraints of a clinically functional intravascular ultrasound catheter. In this study, we describe the design and fabrication of a dual-frequency catheter using a bidirectional transducer stack with center frequencies of approximately 30 and 80 MHz...
November 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28969142/pure-villous-adenoma-of-the-vesicoureteric-junction-presenting-as-pyonephrosis
#5
Gwendolyn Fernandes, Shital Munde, Amey Rojekar
Villous adenomas of the urinary tract are uncommon neoplasms which share similar morphological features with gastrointestinal villous adenomas. Only two case series and around 20 scattered case reports of villous adenoma in the urinary tract have been published in English literature till date. They have been identified mainly in the urinary bladder, urethra, prostate and urachus, but the occurrence of villous adenomas at the vesicoureteric junction has not been described. We present a case of villous adenoma of the vesicoureteric junction which completely occluded the lumen and led to gross pyonephrosis...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28961341/biophysical-insight-into-the-heparin-peptide-interaction-and-its-modulation-by-a-small-molecule
#6
Neha Tiwari, Ankit Srivastava, Bishwajit Kundu, Manoj Munde
The heparin-protein interaction plays a vital role in numerous physiological and pathological processes. Not only is the binding mechanism of these interactions poorly understood, studies concerning their therapeutic targeting are also limited. Here, we have studied the interaction of the heparin interacting peptide (HIP) from Tat (which plays important role in HIV infections) with heparin. Isothermal titration calorimetry binding exhibits distinct biphasic isotherm with two different affinities in the HIP-heparin complex formation...
September 29, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28894299/dhea-inhibits-acute-microglia-mediated-inflammation-through-activation-of-the-trka-akt1-2-creb-jmjd3-pathway
#7
V I Alexaki, G Fodelianaki, A Neuwirth, C Mund, A Kourgiantaki, E Ieronimaki, K Lyroni, M Troullinaki, C Fujii, W Kanczkowski, A Ziogas, M Peitzsch, S Grossklaus, B Sönnichsen, A Gravanis, S R Bornstein, I Charalampopoulos, C Tsatsanis, T Chavakis
Dehydroepiandrosterone (DHEA) is the most abundant circulating steroid hormone in humans, produced by the adrenals, the gonads and the brain. DHEA was previously shown to bind to the nerve growth factor receptor, tropomyosin-related kinase A (TrkA), and to thereby exert neuroprotective effects. Here we show that DHEA reduces microglia-mediated inflammation in an acute lipopolysaccharide-induced neuro-inflammation model in mice and in cultured microglia in vitro. DHEA regulates microglial inflammatory responses through phosphorylation of TrkA and subsequent activation of a pathway involving Akt1/Akt2 and cAMP response element-binding protein...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28839255/intrinsic-resistance-switching-in-amorphous-silicon-suboxides-the-role-of-columnar-microstructure
#8
M S Munde, A Mehonic, W H Ng, M Buckwell, L Montesi, M Bosman, A L Shluger, A J Kenyon
We studied intrinsic resistance switching behaviour in sputter-deposited amorphous silicon suboxide (a-SiO x ) films with varying degrees of roughness at the oxide-electrode interface. By combining electrical probing measurements, atomic force microscopy (AFM), and scanning transmission electron microscopy (STEM), we observe that devices with rougher oxide-electrode interfaces exhibit lower electroforming voltages and more reliable switching behaviour. We show that rougher interfaces are consistent with enhanced columnar microstructure in the oxide layer...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699157/determination-of-cyclic-volatile-methylsiloxanes-in-personal-care-products-by-gas-chromatography
#9
H M Brothers, T Boehmer, R A Campbell, S Dorn, J J Kerbleski, S Lewis, C Mund, D Pero, K Saito, M Wieser, W Zoller
OBJECTIVE: Organosiloxanes are prevalent in personal care products (PCPs) due to the desired properties they impart in the usage and application of such products. However, the European Chemical Agency (ECHA) has recently published restriction proposals on the amount of two cyclic siloxanes, octamethylcyclotetrasiloxane (D4) and decamethylcyclotetrasiloxane (D5), allowed in wash off products such as shampoos and conditioners which are discharged down the drain during consumer use. This legislation will require that reliable analytical methods are available for manufacturers and government agencies to use in documenting compliance with the restrictions...
July 12, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28669379/the-prevalence-of-gestational-diabetes
#10
Hanne Melchior, Diana Kurch-Bek, Monika Mund
BACKGROUND: Gestational diabetes mellitus (GDM) is defined as a glucose tolerance disorder that arises during pregnancy. Estimates of its prevalence vary widely because of varying threshold values. Screening of all pregnant women with a two-step test has been available in Germany since 2012. This study is the first population-based, nationwide analysis of the screening coverage and the resulting one-year prevalence. METHODS: Billing data from the outpatient sector were analyzed for all persons covered by statutory health insurance in the two-year period 2014-2015...
July 16, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28667641/optimization-of-pectinase-assisted-and-tri-solvent-mediated-extraction-and-recovery-of-lycopene-from-waste-tomato-peels
#11
Pravin J Munde, Abhijeet B Muley, Mayur R Ladole, Amesh V Pawar, Mohammed I Talib, Vishal R Parate
In the present work, optimization of pectinase-assisted and tri-solvent-mediated extraction of lycopene from waste tomato peels was carried out. The optimized parameters for enzymatic pre-treatment were 2% pectinase concentration, pH 5.5, 4-h incubation, 45 °C and 150 rpm. Maximum recovery of lycopene from tomato peels using optimized tri-solvent extraction was achieved at 45 °C, 120-min incubation and 200 rpm. The extracted lycopene was confirmed through functional and characteristic peaks in UV-Vis and FTIR spectra and with retention time in HPLC...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28623337/impact-of-module-x2-and-carbohydrate-binding-module-3-on-the-catalytic-activity-of-associated-glycoside-hydrolases-towards-plant-biomass
#12
Nandita Pasari, Nidhi Adlakha, Mayank Gupta, Zeenat Bashir, Girish H Rajacharya, Garima Verma, Manoj Munde, Rakesh Bhatnagar, Syed Shams Yazdani
Cellulolytic enzymes capable of hydrolyzing plant biomass are secreted by microbial cells specifically in response to the carbon substrate present in the environment. These enzymes consist of a catalytic domain, generally appended to one or more non-catalytic Carbohydrate Binding Module (CBM), which enhances their activity towards recalcitrant biomass. In the present study, the genome of a cellulolytic microbe Paenibacillus polymyxa A18 was annotated for the presence of CBMs and analyzed their expression in response to the plant biomass and model polysaccharides Avicel, CMC and xylan using quantitative PCR...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611251/erratum-for-mund-et-al-the-fitness-of-pseudomonas-aeruginosa-quorum-sensing-signal-cheats-is-influenced-by-the-diffusivity-of-the-environment
#13
Anne Mund, Stephen P Diggle, Freya Harrison
No abstract text is available yet for this article.
June 13, 2017: MBio
https://www.readbyqxmd.com/read/28589449/surprising-twist-in-the-plot-sister-mary-joseph-s-nodule-of-pancreatic-cancer-mimicking-wound-infection-after-umbilical-hernia-repair
#14
Andreas M Luu, K Meurer, T Herzog, J Munding, W Uhl, C Braumann
No abstract text is available yet for this article.
June 6, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28504974/diffusion-and-aggregation-of-oxygen-vacancies-in-amorphous-silica
#15
Manveer S Munde, David Z Gao, Alexander L Shluger
Using density functional theory (DFT) calculations, we investigated oxygen vacancy diffusion and aggregation in relation to dielectric breakdown in amorphous silicon dioxide (a-SiO2). Our calculations indicate the existence of favourable sites for the formation of vacancy dimers and trimers in the amorphous network with maximum binding energies of approximately 0.13 eV and 0.18 eV, respectively. However, an average energy barrier height for neutral vacancy diffusion is found to be about 4.6 eV, rendering this process unfeasible...
June 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28473063/weight-loss-achieved-using-an-energy-restriction-diet-with-normal-or-higher-dietary-protein-decreased-the-number-of-cd14-cd16-proinflammatory-monocytes-and-plasma-lipids-and-lipoproteins-in-middle-aged-overweight-and-obese-adults
#16
Jung Eun Kim, Ge Lin, Jing Zhou, Julie A Mund, Jamie Case, Wayne W Campbell
Monocytes are involved in immune responses, and specific monocyte subpopulations (MS) that express intermediate to high levels of CD16 are associated with obesity and cardiovascular events. Consuming high protein (HP) when dieting improves body composition and cardiometabolic health outcomes, but whether HP affects MS during weight loss remains unknown. We assessed the effect of HP on energy restriction (ER)-induced changes in MS in overweight and obese adults. The relations between MS and plasma lipids and lipoproteins were also examined...
April 2017: Nutrition Research
https://www.readbyqxmd.com/read/28465424/the-fitness-of-pseudomonas-aeruginosa-quorum-sensing-signal-cheats-is-influenced-by-the-diffusivity-of-the-environment
#17
Anne Mund, Stephen P Diggle, Freya Harrison
Experiments examining the social dynamics of bacterial quorum sensing (QS) have focused on mutants which do not respond to signals and the role of QS-regulated exoproducts as public goods. The potential for QS signal molecules to themselves be social public goods has received much less attention. Here, we analyze how signal-deficient (lasI) mutants of the opportunistic pathogen Pseudomonas aeruginosa interact with wild-type cells in an environment where QS is required for growth. We show that when growth requires a "private" intracellular metabolic mechanism activated by the presence of QS signal, lasI mutants act as social cheats and outcompete signal-producing wild-type bacteria in mixed cultures, because they can exploit the signals produced by wild-type cells...
May 2, 2017: MBio
https://www.readbyqxmd.com/read/28427365/association-between-fc%C3%AE-receptor-iia-iiia-and-iiib-genetic-polymorphisms-and-susceptibility-to-severe-malaria-anemia-in-children-in-western-kenya
#18
Elly O Munde, Winnie A Okeyo, Evans Raballah, Samuel B Anyona, Tom Were, John M Ong'echa, Douglas J Perkins, Collins Ouma
BACKGROUND: Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of opsonized microbes, thereby, linking humoral and cellular immunity. FcγR polymorphisms influence binding affinity to IgGs and consequently, can influence clinical malaria outcomes. Specifically, variations in FcγRIIA -131Arg/His, FcγRIIIA-176F/V and FcγRIIIB-NA1/NA2 modulate immune responses through altered binding preferences to IgGs and immune complexes...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28427357/haplotype-of-non-synonymous-mutations-within-il-23r-is-associated-with-susceptibility-to-severe-malaria-anemia-in-a-p-falciparum-holoendemic-transmission-area-of-kenya
#19
Elly O Munde, Evans Raballah, Winnie A Okeyo, John M Ong'echa, Douglas J Perkins, Collins Ouma
BACKGROUND: Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility factors in immune regulatory genes offers an important tool for deciphering malaria pathogenesis. The IL-23/IL-17 immune pathway is important for both immunity and erythropoiesis via its effects through IL-23 receptors (IL-23R). However, the impact of IL-23R variants on SMA has not been fully elucidated...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28425671/activity-based-probes-for-hect-e3-ubiquitin-ligases
#20
Robert Byrne, Thomas Mund, Julien D F Licchesi
Activity-based probes (ABPs) have been used to dissect the biochemical/structural properties and cellular functions of deubiquitinases. However, their utility in studying cysteine-based E3 ubiquitin ligases has been limited. In this study, we evaluate the use of ubiquitin-ABPs (Ub-VME and Ub-PA) and a novel set of E2-Ub-ABPs on a panel of HECT E3 ubiquitin ligases. Our in vitro data show that ubiquitin-ABPs can label HECT domains. We also provide the first evidence that, in addition to the RBR E3 ubiquitin ligase Parkin, E2-Ub-ABPs can also label the catalytic HECT domains of NEDD4, UBE3C, and HECTD1...
July 18, 2017: Chembiochem: a European Journal of Chemical Biology
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