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https://www.readbyqxmd.com/read/27925565/consistency-will-save-lives
#1
Sonia Munde
The term 'blue inhaler' has been synonymous with asthma patients' reliever medication for many years. It's an example of clear, simple, consistent health messaging that is used widely and successfully by people with asthma and healthcare professionals.
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27895986/combined-frequency-domain-photoacoustic-and-ultrasound-imaging-for-intravascular-applications
#2
Robin F Castelino, Michael Hynes, Chelsea E Munding, Sergey Telenkov, F Stuart Foster
Intravascular photoacoustic (IVPA) imaging has the potential to characterize lipid-rich structures based on the optical absorption contrast of tissues. In this study, we explore frequency domain photoacoustics (FDPA) for intravascular applications. The system employed an intensity-modulated continuous wave (CW) laser diode, delivering 1W over an intensity modulated chirp frequency of 4-12MHz. We demonstrated the feasibility of this approach on an agar vessel phantom with graphite and lipid targets, imaged using a planar acoustic transducer co-aligned with an optical fibre, allowing for the co-registration of IVUS and FDPA images...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27820601/scai-promotes-dna-double-strand-break-repair-in-distinct-chromosomal-contexts
#3
Rebecca Kring Hansen, Andreas Mund, Sara Lund Poulsen, Maria Sandoval, Karolin Klement, Katerina Tsouroula, Maxim A X Tollenaere, Markus Räschle, Rebeca Soria, Stefan Offermanns, Thomas Worzfeld, Robert Grosse, Dominique T Brandt, Björn Rozell, Matthias Mann, Francesca Cole, Evi Soutoglou, Aaron A Goodarzi, Jeremy A Daniel, Niels Mailand, Simon Bekker-Jensen
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions, whose accurate repair by non-homologous end-joining (NHEJ) or homologous recombination (HR) is crucial for genome integrity and is strongly influenced by the local chromatin environment. Here, we identify SCAI (suppressor of cancer cell invasion) as a 53BP1-interacting chromatin-associated protein that promotes the functionality of several DSB repair pathways in mammalian cells. SCAI undergoes prominent enrichment at DSB sites through dual mechanisms involving 53BP1-dependent recruitment to DSB-surrounding chromatin and 53BP1-independent accumulation at resected DSBs...
November 7, 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27808344/s100a9-induces-monocyte-macrophage-migration-via-emmprin
#4
Vasileia Ismini Alexaki, Andreas E May, Chika Fujii, Saskia N I V Ungern-Sternberg, Christine Mund, Meinrad Gawaz, Triantafyllos Chavakis, Peter Seizer
No abstract text is available yet for this article.
November 3, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27766165/association-of-campylobacter-jejuni-ssp-jejuni-chemotaxis-receptor-genes-with-multilocus-sequence-types-and-source-of-isolation
#5
Norah Lynn-Anne Mund, Wycliffe Omurwa Masanta, Anne-Marie Goldschmidt, Raimond Lugert, Uwe Groß, Andreas E Zautner
Campylobacter jejuni's flagellar locomotion is controlled by eleven chemoreceptors. Assessment of the distribution of the relevant chemoreceptor genes in the C. jejuni genomes deposited in the National Center for Biotechnology Information (NCBI) database led to the identification of two previously unknown tlp genes and a tlp5 pseudogene. These two chemoreceptor genes share the same locus in the C. jejuni genome with tlp4 and tlp11, but the gene region encoding the periplasmic ligand binding domain differs significantly from other chemoreceptor genes...
September 29, 2016: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/27718142/the-effect-of-anomalous-utterances-on-language-production
#6
Iva Ivanova, Liane Wardlow, Jill Warker, Victor S Ferreira
Speakers sometimes encounter utterances that have anomalous linguistic features. Are such features registered during comprehension and transferred to speakers' production systems? In two experiments, we explored these questions. In a syntactic-priming paradigm, speakers heard prime sentences with novel or intransitive verbs as part of prepositional-dative or double-object structures (e.g., The chef munded the cup to the burglar or The doctor existed the pirate the balloon). Speakers then described target pictures eliciting the same structures, using the same or different novel or intransitive verbs...
October 7, 2016: Memory & Cognition
https://www.readbyqxmd.com/read/27601823/enigmatic-insight-into-collagen
#7
REVIEW
Shrutal Narendra Deshmukh, Alka M Dive, Rohit Moharil, Prashant Munde
Collagen is a unique, triple helical molecule which forms the major part of extracellular matrix. It is the most abundant protein in the human body, representing 30% of its dry weight. It is the fibrous structural protein that makes up the white fibers (collagen fibers) of skin, tendons, bones, cartilage and all other connective tissues. Collagens are not only essential for the mechanical resistance and resilience of multicellular organisms, but are also signaling molecules defining cellular shape and behavior...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27596623/loss-of-chd1-causes-dna-repair-defects-and-enhances-prostate-cancer-therapeutic-responsiveness
#8
Vijayalakshmi Kari, Wael Yassin Mansour, Sanjay Kumar Raul, Simon J Baumgart, Andreas Mund, Marian Grade, Hüseyin Sirma, Ronald Simon, Hans Will, Matthias Dobbelstein, Ekkehard Dikomey, Steven A Johnsen
The CHD1 gene, encoding the chromo-domain helicase DNA-binding protein-1, is one of the most frequently deleted genes in prostate cancer. Here, we examined the role of CHD1 in DNA double-strand break (DSB) repair in prostate cancer cells. We show that CHD1 is required for the recruitment of CtIP to chromatin and subsequent end resection during DNA DSB repair. Our data support a role for CHD1 in opening the chromatin around the DSB to facilitate the recruitment of homologous recombination (HR) proteins. Consequently, depletion of CHD1 specifically affects HR-mediated DNA repair but not non-homologous end joining...
September 5, 2016: EMBO Reports
https://www.readbyqxmd.com/read/27580506/effect-of-evidence-based-practice-programs-on-individual-barriers-of-workforce-nurses-an-integrative-review
#9
Reginald Middlebrooks, Heather Carter-Templeton, Angela R Mund
UNLABELLED: HOW TO OBTAIN CONTACT HOURS BY READING THIS ISSUE Instructions: 1.2 contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded after you register, pay the registration fee, and complete the evaluation form online at http://goo...
September 1, 2016: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/27577262/proteome-wide-analysis-of-arginine-monomethylation-reveals-widespread-occurrence-in-human-cells
#10
Sara C Larsen, Kathrine B Sylvestersen, Andreas Mund, David Lyon, Meeli Mullari, Maria V Madsen, Jeremy A Daniel, Lars J Jensen, Michael L Nielsen
The posttranslational modification of proteins by arginine methylation is functionally important, yet the breadth of this modification is not well characterized. Using high-resolution mass spectrometry, we identified 8030 arginine methylation sites within 3300 human proteins in human embryonic kidney 293 cells, indicating that the occurrence of this modification is comparable to phosphorylation and ubiquitylation. A site-level conservation analysis revealed that arginine methylation sites are less evolutionarily conserved compared to arginines that were not identified as modified by methylation...
2016: Science Signaling
https://www.readbyqxmd.com/read/27474575/carboxymethyl-cellulose-enables-silk-fibroin-nanofibrous-scaffold-with-enhanced-biomimetic-potential-for-bone-tissue-engineering-application
#11
B N Singh, N N Panda, R Mund, K Pramanik
Novel silk fibroin (SF) and carboxymethyl cellulose (CMC) composite nanofibrous scaffold (SFC) were developed to investigate their ability to nucleate bioactive nanosized calcium phosphate (Ca/P) by biomineralization for bone tissue engineering application. The composite nanofibrous scaffold was prepared by free liquid surface electrospinning method. The developed composite nanofibrous scaffold was observed to control the size of Ca/P particle (≤100nm) as well as uniform nucleation of Ca/P over the surface...
October 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27461595/proliferative-verrucous-leukoplakia-an-update
#12
REVIEW
Anita Munde, Ravindra Karle
Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behavior due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in elderly women, over 60 years at the time of diagnosis. The buccal mucosa and tongue are the most frequently involved sites...
April 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27418941/acetylsalicylic-acid-as-a-potential-pediatric-health-hazard-legislative-aspects-concerning-accidental-intoxications-in-the-european-union
#13
REVIEW
Menen E Mund, Christoph Gyo, Dörthe Brüggmann, David Quarcoo, David A Groneberg
Acetylsalicylic acid is a frequently used medication worldwide. It is not used in pediatrics due its association with Reye syndrome. However, in case of pediatric intoxication, children are more fragile to salicylate poisoning because of their reduced ability of buffer the acid stress. Intoxication leads to a decoupling of oxidative phosphorylation and subsequently to a loss in mitochondrial function. Symptoms of poisoning are diverse; eventually they can lead to the death of the patient. Governmental websites of various EU countries were searched for legal information on acetylsalicylic acid availability in pharmacies and non-pharmacy stores...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/27334656/nanoscale-transformations-in-metastable-amorphous-silicon-rich-silica
#14
Adnan Mehonic, Mark Buckwell, Luca Montesi, Manveer Singh Munde, David Gao, Stephen Hudziak, Richard J Chater, Sarah Fearn, David McPhail, Michel Bosman, Alexander L Shluger, Anthony J Kenyon
Electrically biasing thin films of amorphous, substoichiometric silicon oxide drives surprisingly large structural changes, apparent as density variations, oxygen movement, and ultimately, emission of superoxide ions. Results from this fundamental study are directly relevant to materials that are increasingly used in a range of technologies, and demonstrate a surprising level of field-driven local reordering of a random oxide network.
September 2016: Advanced Materials
https://www.readbyqxmd.com/read/27301671/remotely-sensed-detection-of-effects-of-extreme-droughts-on-gross-primary-production
#15
Sara Vicca, Manuela Balzarolo, Iolanda Filella, André Granier, Mathias Herbst, Alexander Knohl, Bernard Longdoz, Martina Mund, Zoltan Nagy, Krisztina Pintér, Serge Rambal, Jan Verbesselt, Aleixandre Verger, Achim Zeileis, Chao Zhang, Josep Peñuelas
Severe droughts strongly impact photosynthesis (GPP), and satellite imagery has yet to demonstrate its ability to detect drought effects. Especially changes in vegetation functioning when vegetation state remains unaltered (no browning or defoliation) pose a challenge to satellite-derived indicators. We evaluated the performance of different satellite indicators to detect strong drought effects on GPP in a beech forest in France (Hesse), where vegetation state remained largely unaffected while GPP decreased substantially...
June 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27266634/neurofibromin-is-a-novel-regulator-of-ras-induced-reactive-oxygen-species-production-in-mice-and-humans
#16
Waylan K Bessler, Farlyn Z Hudson, Hanfang Zhang, Valerie Harris, Yusi Wang, Julie A Mund, Brandon Downing, David A Ingram, Jamie Case, David J Fulton, Brian K Stansfield
Neurofibromatosis type 1 (NF1) predisposes individuals to early and debilitating cardiovascular disease. Loss of function mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin, leads to accelerated p21(Ras) activity and phosphorylation of multiple downstream kinases, including Erk and Akt. Nf1 heterozygous (Nf1(+/-)) mice develop a robust neointima that mimics human disease. Monocytes/macrophages play a central role in NF1 arterial stenosis as Nf1 mutations in myeloid cells alone are sufficient to reproduce the enhanced neointima observed in Nf1(+/-) mice...
August 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27223324/phf13-is-a-molecular-reader-and-transcriptional-co-regulator-of-h3k4me2-3
#17
Ho-Ryun Chung, Chao Xu, Alisa Fuchs, Andreas Mund, Martin Lange, Hannah Staege, Tobias Schubert, Chuanbing Bian, Ilona Dunkel, Anton Eberharter, Catherine Regnard, Henrike Klinker, David Meierhofer, Luca Cozzuto, Andreas Winterpacht, Luciano Di Croce, Jinrong Min, Hans Will, Sarah Kinkley
PHF13 is a chromatin affiliated protein with a functional role in differentiation, cell division, DNA damage response and higher chromatin order. To gain insight into PHF13's ability to modulate these processes, we elucidate the mechanisms targeting PHF13 to chromatin, its genome wide localization and its molecular chromatin context. Size exclusion chromatography, mass spectrometry, X-ray crystallography and ChIP sequencing demonstrate that PHF13 binds chromatin in a multivalent fashion via direct interactions with H3K4me2/3 and DNA, and indirectly via interactions with PRC2 and RNA PolII...
2016: ELife
https://www.readbyqxmd.com/read/27215054/taking-care-to-the-streets
#18
Ed Mund
No abstract text is available yet for this article.
April 2016: EMS World
https://www.readbyqxmd.com/read/27123725/-curative-endoscopic-therapy-which-lesions-can-be-addressed
#19
Johanna Munding, Andrea Tannapfel
Since the implementation of a nationwide screening colonoscopy the incidence of colorectal adenocarcinoma is decreasing, while the amount of early endoscopically resectable tumours is increasing. Similarly malignant tumors of the upper gastrointestinal tract are diagnosed and resected endoscopically more often. In part, this also depends on improvements in technology.The current guidelines of diagnosis and treatment of squamous carcinoma and adenocarcinoma of the esophagus, gastric cancer and colorectal cancer exactly define, which lesions can be endoscopically resected curatively...
April 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27076598/endogenous-transmembrane-tnf-alpha-protects-against-premature-senescence-in-endothelial-colony-forming-cells
#20
Linden A Green, Victor Njoku, Julie Mund, Jaime Case, Mervin Yoder, Michael P Murphy, Matthias Clauss
RATIONALE: Transmembrane tumor necrosis factor-α (tmTNF-α) is the prime ligand for TNF receptor 2, which has been shown to mediate angiogenic and blood vessel repair activities in mice. We have previously reported that the angiogenic potential of highly proliferative endothelial colony-forming cells (ECFCs) can be explained by the absence of senescent cells, which in mature endothelial cells occupy >30% of the population, and that exposure to a chronic inflammatory environment induced premature, telomere-independent senescence in ECFCs...
May 13, 2016: Circulation Research
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