Read by QxMD icon Read


Karsten Mahnke, Jurgina Useliene, Sabine Ring, Paula Kage, Verena Jendrossek, Simon C Robson, Matilda Bylaite-Bucinskiene, Kerstin Steinbrink, Alexander H Enk
Injection of regulatory T cells (Treg) followed by sensitization with TNCB induced a transient increase in size and cellularity of skin draining lymph nodes (LN) in mice. This led us to hypothesize that Treg may affect the trafficking of T cells from - and to peripheral LN. Two to three hours after sensitization we found fewer CD8(+) T cells expressing CD62L in LN as compared to untreated controls. Injection of wildtype Treg prevented this down-regulation of CD62L. In contrast, Treg devoid of the ATP-degrading ecto-enzyme CD39 were unable to do so...
September 10, 2016: Journal of Investigative Dermatology
Aleta Pupovac, Ronald Sluyter
Ectodomain shedding of integral membrane receptors results in the release of soluble molecules and modification of the transmembrane portions to mediate or modulate extracellular and intracellular signalling. Ectodomain shedding is stimulated by a variety of mechanisms, including the activation of P2 receptors by extracellular nucleotides. This review describes in detail the roles of extracellular nucleotides and P2 receptors in the shedding of various cell surface molecules, including amyloid precursor protein, CD23, CD62L, and members of the epidermal growth factor, immunoglobulin and tumour necrosis factor families...
May 14, 2016: Cellular and Molecular Life Sciences: CMLS
Laurie Lajoie, Nicolas Congy-Jolivet, Armelle Bolzec, Valérie Gouilleux-Gruart, Elodie Sicard, Hsueh Cheng Sung, Frank Peiretti, Thierry Moreau, Henri Vié, Béatrice Clémenceau, Gilles Thibault
FcγRIIIA/CD16A, the low-affinity receptor for the IgG Fc portion expressed on human CD56(dim) NK cells and involved in Ab-dependent cell cytotoxicity, is shed upon NK cell activation. We found that recombinant a disintegrin and metalloprotease (ADAM) 17 cleaved the ectodomain of FcγRIIIA/CD16A and a peptide for which the sequence encompasses aa 191-201 of the FcγRIIIA/CD16A stalk region but not ADAM10. MALDI-TOF analysis revealed that the peptide was cleaved between Ala(195) and Val(196) (i.e., 1 aa upstream of the expected position)...
January 15, 2014: Journal of Immunology: Official Journal of the American Association of Immunologists
Rizwan Romee, Bree Foley, Todd Lenvik, Yue Wang, Bin Zhang, Dave Ankarlo, Xianghua Luo, Sarah Cooley, Mike Verneris, Bruce Walcheck, Jeffrey Miller
The Fc receptor CD16 is present on essentially all CD56(dim) peripheral blood natural killer (NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to NK cells, which eliminate targets through direct killing and cytokine production. Here we investigated the regulation of CD16 surface expression after NK cell activation. Cytokine activation and target cell stimulation led to marked decreases in CD16 expression. Activation of CD56(dim) NK cells by cross-linking CD16 with antibodies resulted in a loss of CD16 and CD62L, which correlated with increased interferon-γ production...
May 2, 2013: Blood
Gabor Erdoes, Maria L Balmer, Emma Slack, Istvan Kocsis, Lutz E Lehmann, Balthasar Eberle, Frank Stüber, Malte Book
OBJECTIVE: To investigate the suitability of blood granulocyte and monocyte sensitivity, as measured by the quantity of different agonists required to induce CD62L shedding, for assessment of perioperative immune changes in patients undergoing cardiac surgery with cardiopulmonary bypass. METHODS: Patients scheduled for aortocoronary bypass grafting or for valve surgery were included in this prospective observational study. Blood samples were drawn before anesthesia induction, directly after surgery and 48 hours after anesthesia induction...
2013: PloS One
Erica M Hanson, Virginia K Clements, Pratima Sinha, Dan Ilkovitch, Suzanne Ostrand-Rosenberg
Effective cell-mediated antitumor immunity requires the activation of tumor-reactive T cells and the trafficking of activated T cells to tumor sites. These processes involve the extravasation of lymphocytes from the blood and lymphatics, and their homing to lymph nodes and tumors. L-selectin (CD62L) is an important molecule in these processes. It directs naive lymphocytes to peripheral lymph nodes where they become activated and it traffics naive lymphocytes to inflammatory environments, such as tumors. Individuals with advanced cancer are immune suppressed due to myeloid-derived suppressor cells (MDSC), a population of immature myeloid cells that accumulate to high levels in response to tumor-secreted and proinflammatory factors...
July 15, 2009: Journal of Immunology: Official Journal of the American Association of Immunologists
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"