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https://www.readbyqxmd.com/read/27915246/neutrophil-dependent-pentraxin-3-and-reactive-oxygen-species-production-modulate-endothelial-dysfunction-in-haemodialysis-patients
#1
Maria Pia dell'Oglio, Simona Simone, Marco Ciccone, Roberto Corciulo, Michele Gesualdo, Annapaola Zito, Francesca Cortese, Giuseppe Castellano, Margherita Gigante, Loreto Gesualdo, Giuseppe Grandaliano, Giovanni Battista Pertosa
BACKGROUND: The aim of this study was to investigate neutrophil activation and its role in long pentraxin-3 (PTX3) release and oxidative stress generation during haemodialysis (HD) and to correlate neutrophil PTX3 and oxidant expression with endothelial dysfunction. METHODS: Forty-seven uraemic patients on stable HD, 12 healthy subjects and 15 patients with congestive heart failure (New York Heart Association classes III and IV) were enrolled. Neutrophil PTX3 protein expression was evaluated by confocal microscopy...
December 3, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27911915/marathon-race-affects-neutrophil-surface-molecules-role-of-inflammatory-mediators
#2
Vinicius Coneglian Santos, Ana Paula Renno Sierra, Rodrigo Oliveira, Kim Guimarães Caçula, César Miguel Momesso, Fabio Takeo Sato, Maysa Braga Barros Silva, Heloisa Helena Oliveira, Maria Elizabeth Pereira Passos, Diego Ribeiro de Souza, Olivia Santos Gondim, Marino Benetti, Adriana Cristina Levada-Pires, Nabil Ghorayeb, Maria Augusta Peduti Dal Molin Kiss, Renata Gorjão, Tânia Cristina Pithon-Curi, Maria Fernanda Cury-Boaventura
The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the São Paulo International Marathon 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27888602/a-glycovariant-of-human-cd44-is-characteristically-expressed-on-human-mesenchymal-stem-cells
#3
Gisela Pachón-Peña, Conor Donnelly, Catalina Ruiz-Cañada, Adam Katz, Sonia Fernández-Veledo, Joan Vendrell, Robert Sackstein
The clinical effectiveness of systemically-administered human mesenchymal stem cells (hMSCs) depends on their capacity to engage vascular endothelium. hMSCs derived from bone marrow (BM-hMSCs) natively lack endothelial binding capacity but express a CD44 glycovariant containing N-linked sialyllactosamines that can be α(1,3)-fucosylated using fucosyltransferase- VI (FTVI) to enforce sLe(X) decorations, thereby creating hematopoietic cell E-/L-selectin ligand (HCELL). HCELL expression programs potent shear-resistant adhesion of circulating cells to endothelial beds expressing E-selectin...
November 26, 2016: Stem Cells
https://www.readbyqxmd.com/read/27872575/the-significance-and-occurrence-of-tnf-receptor-polymorphisms-in-the-saudi-population
#4
Faris Q Alenzi
Background and objective: On the basis that the inflammatory effects of TNF (tumour necrosis factor) are predominantly mediated through interaction with the TNF receptor-1 (TNFRSF1A), the current study was designed to establish the prevalence of the mutations, R92Q and P46L TNFRSF1A polymorphisms both in the general healthy Saudi population, and in Saudi patients carrying inflammatory diseases such as atherosclerosis or rheumatoid arthritis. We felt it important to report the frequency of the mutations, R92Q and P46L TNFRSF1A polymorphisms in healthy Saudi individuals, and those with inflammatory conditions, as well as to describe the pattern of immunological factors in individuals expressing R92Q or P46L TNFRSF1A...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27871849/cd44-fucosylation-on-mesenchymal-stem-cell-enhances-homing-and-macrophage-polarization-in-ischemic-kidney-injury
#5
Kang-Ju Chou, Po-Tsang Lee, Chien-Liang Chen, Chih-Yang Hsu, Wei-Chieh Huang, Chien-Wei Huang, Hua-Chang Fang
The lack of homing ability possibly reduces the healing potential of bone-marrow-derived mesenchymal stem cells (MSCs). Therefore, transforming native CD44 on MSCs into a hematopoietic cell E-/L-selectin ligand (HCELL) that possesses potent E-selectin affinity might enhance the homing and regenerative abilities of MSCs. Through fucosyltransferase VI (FTVI) transfection, MSCs were fucosylated on N-glycans of CD44 to become HCELL positive, thus interacting with E-selectin on injured endothelial cells. HCELL expression facilitated MSC homing in kidneys within 24hours after injury and reduced lung stasis...
November 18, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27822754/roles-of-leptin-and-ghrelin-in-the-regulation-of-the-phenotype-and-cytokine-production-by-nk-cells-from-peripheral-blood
#6
S V Shirshev, I V Nekrasova, E G Orlova, O L Gorbunova
Both leptin and ghrelin used separately at the concentrations corresponding to trimesters II-III of pregnancy increase the number of CD56(bright) NK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression on the surface of these cells in the culture. These hormones do not affect the production of TGF-β1, IL-17А, or IFN-γ by NK cells, and they inhibit the production of IL-10. Leptin decreses the IL-4 production by NKp46(+) cells, but the presence of ghrelin abrogates this effect...
September 2016: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/27763813/trojan-horse-l-selectin-monocytes-a-portal-of-burkholderia-pseudomallei-entry-into-the-brain
#7
James A St John
No abstract text is available yet for this article.
October 20, 2016: Virulence
https://www.readbyqxmd.com/read/27735833/effects-of-almond-and-olive-oil-based-docosahexaenoic-and-vitamin-e-enriched-beverage-dietary-supplementation-on-inflammation-associated-to-exercise-and-age
#8
Xavier Capó, Miquel Martorell, Antoni Sureda, Joan Riera, Franchek Drobnic, Josep Antoni Tur, Antoni Pons
n-3-polyunsaturated fatty acids and polyphenols are potential key factors for the treatment and prevention of chronic inflammation associated to ageing and non-communicable diseases. The aim was to analyse effects of an almond and olive oil beverage enriched with α-tocopherol and docosahexaenoic, exercise and age on inflammatory plasma markers, and immune gene expression in peripheral blood mononuclear cells (PBMCs). Five young and five senior athletes who were supplemented for five weeks with a functional beverage performed a stress test under controlled conditions before and after beverage supplementation...
October 9, 2016: Nutrients
https://www.readbyqxmd.com/read/27711121/identification-of-ompa-like-protein-of-tannerella-forsythia-as-an-o-linked-glycoprotein-and-its-binding-capability-to-lectins
#9
Toshi Horie, Megumi Inomata, Takeshi Into, Yoshiaki Hasegawa, Noriyuki Kitai, Fuminobu Yoshimura, Yukitaka Murakami
Bacterial glycoproteins are associated with physiological and pathogenic functions of bacteria. It remains unclear whether bacterial glycoproteins can bind to specific classes of lectins expressed on host cells. Tannerella forsythia is a gram-negative oral anaerobe that contributes to the development of periodontitis. In this study, we aimed to find lectin-binding glycoproteins in T. forsythia. We performed affinity chromatography of wheat germ agglutinin, which binds to N-acetylglucosamine (GlcNAc) and sialic acid (Sia), and identified OmpA-like protein as the glycoprotein that has the highest affinity...
2016: PloS One
https://www.readbyqxmd.com/read/27686084/markers-of-endothelial-dysfunction-and-leucocyte-activation-in-saudi-and-non-saudi-haplotypes-of-sickle-cell-disease
#10
Salwa Al Najjar, Soheir Adam, Nessar Ahmed, Mohamed Qari
Sickle cell disease (SCD) is an autosomal recessive inherited hemoglobinopathy, characterized by chronic hemolysis and recurrent vaso-occlusive crisis (VOC). This study investigates changes in leucocyte subsets and the relationship between cell adhesion molecule expression and disease manifestations in patients during steady state and acute VOC. We compared soluble E-selectin and P-selectin levels in 84 SCD patients, in steady state and during VOC to 84 healthy controls. Using immunophenotyping, we also compared lymphocyte subsets in these three groups...
September 30, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27663375/bovine-p-selectin-mediates-leukocyte-adhesion-and-is-highly-polymorphic-in-dairy-breeds
#11
Xing Chen, Zhangrui Cheng, Dirk Werling, Geoffrey E Pollott, Mazdak Salavati, Kate F Johnson, Faheem Ahmed Khan, D Claire Wathes, Shujun Zhang
Bovine P-selectin (SELP) mediates leukocyte rolling and primes leukocyte adhesion to endothelium, both essential for leukocyte recruitment to an infection site. We investigated SELP-mediated adhesion between bovine peripheral blood leukocytes (PBLs) and cultured bovine aortic endothelial cells pre-activated with lipopolysaccharide (LPS). We examined gene polymorphism for bovine selectins SELP, l-selectin (SELL) and E-selectin (SELE) and compared their SNP frequency between five dairy breeds (Holstein, Friesian, Jersey, Ayrshire and Brown Swiss)...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27646437/involvement-of-l-selectin-expression-in-burkholderia-pseudomallei-infected-monocytes-invading-the-brain-during-murine-melioidosis
#12
Yao-Shen Chen, Hsi-Hsun Lin, Pei-Tan Hsueh, Wei-Fan Ni, Pei-Ju Liu, Pei-Shih Chen, Hsin-Hou Chang, Der-Shan Sun, Ya-Lei Chen
The development of neurologic melioidosis was linked to the elicitation of Burkholderia pseudomallei-infected L-selectin(hi)CD11b(+) BALB/c cells in our previous study. However, whether monocytic L-selectin (CD62L, encoded by the sell gene) is a key factor remains uncertain. In the present study, after establishing multi-organ foci via hematogenous routes, we demonstrated that B. pseudomallei GFP steadily persisted in blood, splenic, hepatic and bone marrow (BM) Ly6C monocytes; however, the circulating CD16/32(+)CD45(hi)GFP(+) brain-infiltrating leukocytes (BILs) derived from the blood Ly6C monocytes were expanded in BALB/c but not in C57BL/6 bacteremic melioidosis...
September 19, 2016: Virulence
https://www.readbyqxmd.com/read/27629486/enhanced-t-cell-responses-to-il-6-in-type-1-diabetes-are-associated-with-early-clinical-disease-and-increased-il-6-receptor-expression
#13
Christian Hundhausen, Alena Roth, Elizabeth Whalen, Janice Chen, Anya Schneider, S Alice Long, Shan Wei, Rebecca Rawlings, MacKenzie Kinsman, Stephen P Evanko, Thomas N Wight, Carla J Greenbaum, Karen Cerosaletti, Jane H Buckner
Interleukin-6 (IL-6) is a key pathogenic cytokine in multiple autoimmune diseases including rheumatoid arthritis and multiple sclerosis, suggesting that dysregulation of the IL-6 pathway may be a common feature of autoimmunity. The role of IL-6 in type 1 diabetes (T1D) is not well understood. We show that signal transducer and activator of transcription 3 (STAT3) and STAT1 responses to IL-6 are significantly enhanced in CD4 and CD8 T cells from individuals with T1D compared to healthy controls. The effect is IL-6-specific because it is not seen with IL-10 or IL-27 stimulation, two cytokines that signal via STAT3...
September 14, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27620619/high-salivary-soluble-l-selectin-and-interleukin-7-levels-in-asian-indian-patients-with-primary-sj%C3%A3-gren-s-syndrome
#14
Jayakanthan Kabeerdoss, Pulukool Sandhya, Santosh Kumar Mandal, Mahasampath Gowri, Debashish Danda
In present study, we aimed to study salivary soluble L-selectin (sL-selectin), interleukin-7(IjL-7), and lymphotoxin-α levels in primary Sjögren's syndrome (pSS) and their clinical as well as serological correlations. pSS patients fulfilling either the American European Consensus Group (AECG) and/or the American college of Rheumatology (ACR) criteria were recruited. Age- and sex-matched hospital staff were recruited as healthy controls. Unstimulated saliva was collected by the spitting method; sL-selectin, IL-7, and lymphotoxin-α were measured in the saliva using commercial ELISA kits...
September 12, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27566170/the-protective-role-of-pac1-receptor-agonist-maxadilan-in-bccao-induced-retinal-degeneration
#15
A Vaczy, D Reglodi, T Somoskeoy, K Kovacs, E Lokos, E Szabo, A Tamas, T Atlasz
A number of studies have proven that pituitary adenylate cyclase activating polypeptide (PACAP) is protective in neurodegenerative diseases. Permanent bilateral common carotid artery occlusion (BCCAO) causes severe degeneration in the rat retina. In our previous studies, protective effects were observed with PACAP1-38, PACAP1-27, and VIP but not with their related peptides, glucagon, or secretin in BCCAO. All three PACAP receptors (PAC1, VPAC1, VPAC2) appear in the retina. Molecular and immunohistochemical analysis demonstrated that the retinoprotective effects are most probably mainly mediated by the PAC1 receptor...
October 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27565875/expression-profiling-of-innate-immune-genes-in-milk-somatic-cells-during-subclinical-mastitis-in-crossbred-dairy-cows
#16
A Karthikeyan, G Radhika, T V Aravindhakshan, K Anilkumar
Innate immune mechanism plays a key role in mammary defense, from recognition of pathogens to activation of nonspecific and specific immunity involved in elimination of pathogens. Expression profiles of innate immune response genes namely Toll like receptor 2 (TLR-2), Peptidoglycan recognition protein 1 (PGLYRP-1), Interleukin 8 receptor (IL-8 R), L-Selectin (SELL), and Osteopontin (OPN) in milk somatic cells of subclinical mastitis (SCM) affected crossbred cows were investigated under this study at transcript level using quantitative real time polymerase chain reaction (qRT-PCR)...
October 2016: Animal Biotechnology
https://www.readbyqxmd.com/read/27555845/biosynthesis-and-functional-significance-of-peripheral-node-addressin-in-cancer-associated-tlo
#17
REVIEW
Aliyah M Weinstein, Walter J Storkus
Peripheral node addressin (PNAd) marks high endothelial venules (HEV), which are crucial for the recruitment of lymphocytes into lymphoid organs in non-mucosal tissue sites. PNAd is a sulfated and fucosylated glycoprotein recognized by the prototypic monoclonal antibody, MECA-79. PNAd is the ligand for L-selectin, which is expressed on the surface of naive and central memory T cells, where it mediates leukocyte rolling on vascular endothelial surfaces. Although PNAd was first identified in the HEV of peripheral lymph nodes, recent work suggests a critical role for PNAd in the context of chronic inflammatory diseases, where it can be used as a marker for the formation of tertiary lymphoid organs (TLOs)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27549988/sevuparin-binds-to-multiple-adhesive-ligands-and-reduces-sickle-red-blood-cell-induced-vaso-occlusion
#18
Marilyn J Telen, Milena Batchvarova, Siqing Shan, Petra H Bovee-Geurts, Rahima Zennadi, Anna Leitgeb, Roland Brock, Maria Lindgren
Sevuparin is a novel drug candidate in phase II development as a treatment for vaso-occlusive crises (VOC) in patients with sickle cell disease (SCD). As a heparin-derived polysaccharide, sevuparin has been designed to retain anti-adhesive properties, while the antithrombin-binding domains have been eliminated, substantially diminishing its anticoagulant activity. Here, we demonstrate that sevuparin inhibits the adhesion of human sickle red blood cells (SS-RBCs) to stimulated cultured endothelial cells in vitro...
August 23, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27502305/overexpression-of-antimicrobial-anticancer-and-transmembrane-peptides-in-escherichia-coli-through-a-calmodulin-peptide-fusion-system
#19
Hiroaki Ishida, Leonard T Nguyen, Ramamourthy Gopal, Tomoyasu Aizawa, Hans J Vogel
In recent years, the increasing number of antibiotic-resistant bacteria has become a serious health concern. Antimicrobial peptides (AMPs) are an important component of the innate immune system of most organisms. A better understanding of their structures and mechanisms of action would lead to the design of more potent and safer AMPs as alternatives for current antibiotics. For detailed investigations, effective recombinant production which allows the facile modification of the amino acid sequence, the introduction of unnatural amino acids, and labeling with stable isotopes for nuclear magnetic resonance (NMR) studies is desired...
September 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27498916/inhaled-corticosteroids-increase-blood-neutrophil-count-by-decreasing-the-expression-of-neutrophil-adhesion-molecules-mac-1-and-l-selectin
#20
Yehonatan Pasternak, Havatzelet Yarden-Bilavsky, Yona Kodman, Meira Zoldan, Hannah Tamary, Shai Ashkenazi
OBJECTIVE: The objective was to investigate the effect of commonly used inhaled corticosteroids on white blood cell count (WBC) and to examine the mechanisms involved. METHODS: This randomized comparative study comprised 60 healthy adults. We measured the effects of budesonide (by face mask inhalation or aerosol inhaler), fluticasone (by inhaler), and saline inhalation (control) on WBC and the differential leukocyte count, especially the absolute neutrophil count (ANC)...
October 2016: American Journal of Emergency Medicine
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