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https://www.readbyqxmd.com/read/29893827/prediction-of-electro-anatomical-substrate-using-apple-score-and-biomarkers
#1
Jelena Kornej, Petra Büttner, Philipp Sommer, Nikolaos Dagres, Borislav Dinov, Katja Schumacher, Andreas Bollmann, Gerhard Hindricks
Aims: Low voltage areas (LVAs) represent advanced remodelling processes in left atrium in patients with atrial fibrillation (AF) and are associated with higher rates of arrhythmia recurrences. However, the prediction of LVA based on clinical parameters is understudied. Recently, we introduced APPLE score to predict rhythm outcomes after catheter ablation. The aim of this study was to analyse (i) LVA prediction using APPLE score and (ii) differences in biomarker profiles according to APPLE score in AF patients...
June 8, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29860036/inflammatory-and-oxidative-stress-parameters-as-potential-early-biomarkers-for-silicosis
#2
REVIEW
Jessica Nardi, Sabrina Nascimento, Gabriela Göethel, Bruna Gauer, Elisa Sauer, Nuryan Fão, Larissa Cestonaro, Caroline Peruzzi, Jorge Souza, Solange Cristina Garcia
Workers involved in mining activities are exposed to crystalline silica, which leads to constant pulmonary inflammatory reactions and severe oxidative damage, resulting in silicosis. In this work, we aimed to evaluate inflammatory and oxidative stress parameters as potential early biomarkers of effect to assess crystalline silica toxicity in workers who had occupational exposure during mining. We enrolled 38 workers exposed to crystalline silica (WECS), 24 individuals with silicosis (IWS), and 30 occupationally unexposed workers (OUW), a total of 92 participants...
May 31, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29850638/cytokines-in-preterm-delivery-proposal-of-a-new-diagnostic-algorithm
#3
Grzegorz Raba, Jacek Tabarkiewicz
Predicting preterm delivery within 7 days is very important for the proper timing of glucocorticosteroid administration. If within 7 days after glucocorticosteroid administration, the delivery does not occur, it remains questionable if repeated glucocorticosteroid therapy results in improved infant respiratory function. Therefore, differentiation of preterm delivery from false preterm delivery is clinically significant. The aim of this study was to create a diagnostic algorithm to distinguish preterm delivery from false preterm delivery on the basis of concentrations of selected cytokines...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29777033/sequential-binding-of-ezrin-and-moesin-to-l-selectin-regulates-monocyte-protrusive-behaviour-during-transmigration
#4
Angela Rey-Gallardo, Hannah Tomlins, Justin Joachim, Izajur Rahman, Phoebe Kitscha, Karen Frudd, Maddy Parsons, Aleksandar Ivetic
Leukocyte transendothelial migration (TEM) is absolutely fundamental to the inflammatory response, involving initial pseudopod protrusion and subsequent polarised migration across inflamed endothelium. Ezrin/radixin/moesin (ERM) proteins are expressed in leukocytes and mediate cell shape change and polarity. The spatio-temporal organisation of ERM with their targets, and their individual contribution to protrusion during TEM, has never been explored. Here we show that blocking PIP2 binding reduces C-terminal phosphorylation of moesin during monocyte TEM, and that on/off cycling of ERM activity is essential for pseudopod protrusion into the subendothelial space...
May 18, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29775225/cytokines-and-chemokines-differentially-regulate-innate-immune-cell-trafficking-during-post-kala-azar-dermal-leishmaniasis
#5
Ashish K Singh, Vidya N R Das, Ajay Amit, Manas R Dikhit, Vijaya Mahantesh, Shubhankar K Singh, Shyam Naryan, Krishna Pandey, Pradeep Das, Neena Verma, Sanjiva Bimal
Post kala-azar dermal leishmaniasis (PKDL) is often considered to be the anthroponotic reservoir of visceral leishmaniasis (VL) in India. A better understanding of the host immune-response in dermal lesions of PKDL patients is therefore of utmost significance to minimize such patients and to restrict VL transmission. Although the innate immune response is known to play an important role in parasite clearance from dermal lesions, the actual contribution of innate cells to the pathogenicity of PKDL is poorly understood...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29729385/the-chinese-herbal-formula-zhibai-dihuang-granule-treat-yin-deficiency-heat-syndrome-rats-by-regulating-the-immune-responses
#6
Chang-Ming Liu, Jing Chen, Su Yang, Lian-Gen Mao, Ting-Ting Jiang, Hui-Hui Tu, Zhong-Liang Chen, Yu-Ting Hu, Lin Gan, Zhong-Jie Li, Ji-Cheng Li
ETHNOPHARMACOLOGICAL RELEVANCE: Zhibai Dihuang Granule (ZDG), a traditional Chinese medicine (TCM) made from eight Chinese herbs, has been classically used to treat Yin-deficiency-heat (YDH) syndrome. ZDG is well known with the therapeutic efficacy of nourishing Yin and decreasing internal heat in clinic, but the mechanism of ZDG's therapeutic effect is still not clear. MATERIALS AND METHODS: High doses of triiodothyronine (T3) were given intraperitoneally to induce Hyperthyroid YDH syndrome in SD rats...
May 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29694864/molecular-dynamics-of-the-association-of-l-selectin-and-ferm-regulated-by-pip2
#7
Fude Sun, Carsten F E Schroer, Lida Xu, Huiwei Yin, Siewert J Marrink, Shi-Zhong Luo
Phosphatidylinositol 4,5-bisphosphate (PIP2) acts as a signaling lipid, mediating membrane trafficking and recruitment of proteins to membranes. A key example is the PIP2-dependent regulation of the adhesion of L-selectin to the cytoskeleton adaptors of the N-terminal subdomain of ezrin-radixin-moesin (FERM). The molecular details of the mediating behavior of multivalent anionic PIP2 lipids in this process, however, remain unclear. Here, we use coarse-grained molecular dynamics simulation to explore the mechanistic details of PIP2 in the transformation, translocation, and association of the FERM/L-selectin complex...
April 24, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29669284/manifold-roles-of-ccr7-and-its-ligands-in-the-induction-and-maintenance-of-bronchus-associated-lymphoid-tissue
#8
Henrike Fleige, Berislav Bosnjak, Marc Permanyer, Jasmin Ristenpart, Anja Bubke, Stefanie Willenzon, Gerd Sutter, Sanjiv A Luther, Reinhold Förster
The processes underlying the development and maintenance of tertiary lymphoid organs are incompletely understood. Using a Ccr7 knockout/knockin approach, we show that spontaneous bronchus-associated lymphoid tissue (BALT) formation can be caused by CCR7-mediated migration defects of dendritic cells (DCs) in the lung. Plt/plt mice that lack the CCR7 ligands CCL19 and CCL21-serine do not form BALT spontaneously because lung-expressed CCL21-leucine presumably suffices to maintain steady-state DC egress. However, plt/plt mice are highly susceptible to modified vaccinia virus infection, showing enhanced recruitment of immune cells as well as alterations in CCR7-ligand-mediated lymphocyte egress from the lungs, leading to dramatically enhanced BALT...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29656594/immune-imbalance-of-global-gene-expression-and-cytokine-chemokine-and-selectin-levels-in-the-brains-of-offspring-with-social-deficits-via-maternal-immune-activation
#9
P-T Hsueh, H-H Lin, H-H Wang, C-L Liu, W-F Ni, J-K Liu, H-H Chang, D-S Sun, Y-S Chen, Y-L Chen
The murine maternal immune activation (MIA) offspring model enables longitudinal studies to explore aberrant social behaviors similar to those observed in humans. High levels of cytokines, chemokines and cell adhesion molecules (CAM) have been found in the plasma and/or brains of psychiatric patients. We hypothesized that upregulation of the systemic or brain immune response has an augmenting effect by potentially increasing the interplay between the neuronal and immune systems during the growth of the MIA offspring...
April 15, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29652553/mahonia-oiwakensis-extract-and-its-bioactive-compounds-exert-anti-inflammatory-activities-and-vegf-production-through-m2-macrophagic-polarization-and-stat6-activation
#10
Yea-Chen Liu, Yu-Ying Hsiao, Kuo-Lung Ku, Hui-Fen Liao, Wei-Chun Chao
Macrophages play an indispensable role in the host immune defense. Macrophages can undergo polarization into classically (M1) and alternatively (M2) activated macrophages. M1 macrophages activate immune and inflammatory response, while M2 macrophages are involved in tissue remodeling. Mahonia oiwakensis (Mo) is a herbal medicine in Asia used for its anti-inflammatory and analgesic properties; however, the mechanism is unclear. This study analyzed the effect of Mo extracts and its effects on the polarization of both macrophage RAW264...
April 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29615799/idelalisib-impairs-trem-1-mediated-neutrophil-inflammatory-responses
#11
Astrid Alflen, Nicole Stadler, Pamela Aranda Lopez, Daniel Teschner, Matthias Theobald, Georg Heß, Markus P Radsak
Triggering receptor expressed on myeloid cells (TREM)-1 on polymorphonuclear neutrophils (PMN) regulates innate immune activation in infectious and non-infectious conditions. TREM-1 ligation activates phosphatidyl-inositol 3 kinase (PI3K) triggering all neutrophil effector functions. As idelalisib is a PI3K inhibitor in clinical use for the treatment of non-Hodgkin lymphomas, we asked whether this inhibitor affects PMN functionalities. We analyzed PMNs from healthy donors or lymphoma patients for oxidative burst, phagocytosis, activation markers and IL-8 release upon TREM-1 or TLR ligation ex vivo...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29601599/vcam-1-expression-is-upregulated-by-cd34-cd133-stem-cells-derived-from-septic-patients
#12
Christian Patry, Christoph Remmé, Christian Betzen, Burkhard Tönshoff, Benito A Yard, Grietje Beck, Neysan Rafat
CD34+/CD133+- cells are a bone marrow derived stem cell population, which presumably contain vascular progenitor cells and are associated with improved vascular repair. In this study, we investigated whether the adhesion molecules ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), E-selectin und L-selectin, which are involved in homing of vascular stem cells, are upregulated by CD34+/CD133+-stem cells from septic patients and would be associated with improved clinical outcome...
2018: PloS One
https://www.readbyqxmd.com/read/29575636/interactions-of-fullerene-polyglycerol-sulfates-at-viral-and-cellular-interfaces
#13
Ievgen Donskyi, Moritz Drüke, Kim Silberreis, Daniel Lauster, Kai Ludwig, Christian Kühne, Wolfgang Unger, Christoph Böttcher, Andreas Herrmann, Jens Dernedde, Mohsen Adeli, Rainer Haag
Understanding the mechanism of interactions of nanomaterials at biointerfaces is a crucial issue to develop new antimicrobial vectors. In this work, a series of water-soluble fullerene-polyglycerol sulfates (FPS) with different fullerene/polymer weight ratios and varying numbers of polyglycerol sulfate branches are synthesized, characterized, and their interactions with two distinct surfaces displaying proteins involved in target cell recognition are investigated. The combination of polyanionic branches with a solvent exposed variable hydrophobic core in FPS proves to be superior to analogs possessing only one of these features in preventing interaction of vesicular stomatitis virus coat glycoprotein (VSV-G) with baby hamster kidney cells serving as a model of host cell...
April 2018: Small
https://www.readbyqxmd.com/read/29557229/short-course-of-simvastatin-has-no-effect-on-markers-of-endothelial-activation-in-normolipidemic-patients-with-systemic-sclerosis
#14
Przemyslaw J Kotyla
Objective Statins, a class of 3-hydroxy-3 methyl-glutaryl-coenzyme A reductase inhibitors, are widely used for the treatment of atherosclerosis. Less is known about the role of statins in the treatment of vascular complication in systemic sclerosis (SSc). We therefore performed a short-term interventional study with simvastatin in patients with the diffuse variant of SSc and normal lipid profiles. Methods Twenty-five patients with diffuse SSc were enrolled and received simvastatin at a daily dose of 20 mg for 28 days...
May 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29554266/integration-of-molecules-to-construct-the-processes-of-conceptus-implantation-to-the-maternal-endometrium
#15
K Imakawa, R Bai, K Kusama
During the peri-implantation period, ruminant conceptuses go through rapid elongation, followed by their attachment to the uterine endometrial epithelial cells, during which interferon-tau (IFNT), a trophectodermal cytokine required for the process of maternal recognition of pregnancy, is expressed in a temporal and spatial manner. On d 22 (d 0 = day of estrus), 2 to 3 d after the initiation of bovine conceptus attachment to the uterine epithelium, when IFNT production begins to subside, the expression of molecules related to epithelial-mesenchymal transition, zinc finger E-box binding homeobox 1, snail family transcriptional repressor 2, N-cadherin and vimentin was found in the trophectoderm...
March 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29533506/a-field-applicable-method-for-flow-cytometric-analysis-of-granulocyte-activation-cryopreservation-of-fixed-granulocytes
#16
Karin de Ruiter, Selma van Staveren, Bart Hilvering, Edward Knol, Nienke Vrisekoop, Leo Koenderman, Maria Yazdanbakhsh
Upon activation granulocytes upregulate several adhesion molecules (CD11b) and granule proteins (CD35, CD66b) and shed surface l-selectin (CD62L). These changes in expression, as assessed by flow cytometry, can be used as markers for activation. Whereas these markers are usually studied in fresh blood samples, a new method is required when samples are collected at a field site with no direct access to a flow cytometer. Therefore, we developed and tested a field-applicable method in which fixed leukocytes were cryopreserved...
March 13, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29525428/circulating-pathogen-specific-plasmablasts-in-female-patients-with-upper-genital-tract-infection
#17
Nina V Palkola, Sari H Pakkanen, Oskari Heikinheimo, Jussi M Kantele, Anu Kantele
Mucosal antibodies constitute the first line of adaptive immune defence against invaders in the female genital tract (FGT), yet the sequence of events leading to their production is surprisingly poorly characterized. We explored the induction of pathogen-specific antibody-secreting cells (ASC) as a response to an acute infection in the upper FGT. We recruited 12 patients undergoing surgery due to an upper FGT infection (7/12 blood culture positive, 5/12 negative) and six healthy controls. Pathogens were sampled during surgery and PBMC collected in the acute phase of the disease (days 7-10)...
April 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29472232/genome-wide-association-and-functional-studies-identify-scml4-and-thsd7a-as-novel-susceptibility-genes-for-coronary-artery-disease
#18
Yang Li, Dao Wen Wang, Yundai Chen, Can Chen, Jian Guo, Shu Zhang, Zhijun Sun, Hu Ding, Yan Yao, Lei Zhou, Ke Xu, Chun Song, Fan Yang, Bin Zhao, Han Yan, Wen-Jing Wang, Chong Wu, Xiangfeng Lu, Xueli Yang, Jie Dong, Guyan Zheng, Shuhan Tian, Yanjun Cui, Lijuan Jin, Gangqiong Liu, Hanbin Cui, Shenghuang Wang, Feng Jiang, Changhua Wang, Jeanette Erdmann, Linyao Zeng, Shian Huang, Jianfeng Zhong, Yuehua Ma, Wenjiang Chen, Jianli Sun, Wei Lei, Shenghan Chen, Shaoqi Rao, Dongfeng Gu, Heribert Schunkert, Xiao-Li Tian
OBJECTIVE: The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined genetic screening with functional characterizations to identify novel loci and candidate genes for CAD. APPROACH AND RESULTS: We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs (single nucleotide polymorphisms), rs9486729 ( SCML4 [Scm polycomb group protein-like 4]; odds ratio, 1...
April 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29430726/comparison-of-l-selectin-blood-level-and-gene-polymorphism-in-tuberculosis-patients-with-healthy-individuals
#19
Peyman Eini, Maria Shirvani, Mehrdad Hajilooi, Farzaneh Esna-Ashari
BACKGROUND: The inflammatory response to Mycobacterium tuberculosis bacilli influences tuberculosis (TB) progression. In this study, we aimed to identify the Phe206Leu polymorphism and serum L-selectin level in TB patients, compared to healthy individuals. METHODS: Ninety patients with a diagnosis of TB and 90 healthy controls were selected in this study. The serum L-selectin level was determined, using ELISA. L-selectin polymorphism was also evaluated using PCR...
February 12, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29407321/protective-effect-of-a-novel-technique-for-liver-transplantation-in-the-rat
#20
B Qu, F Yu, G-N Sheng, W Zhang, Y-M Zhang, Y-L Deng, Y Shi, Z-Y Shen
The rat orthotopic liver transplantation model with extremely short anhepatic phase was established to study its protective effect on the recipients and graft. One hundred fifty adult male Wistar rats were randomly divided into three groups: group A (n = 30), using magnetic rings for the suprahepatic vena cava reconstruction; group B (n = 30), using 7/0 Prolene sutures for suprahepatic vena cava running anastomosis as control; and a sham-operated group (n = 30) as a blank control group. The changes in liver enzyme, serum creatinine, endotoxin, and cytokine levels and histopathology were recorded...
January 2018: Transplantation Proceedings
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