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Resting state MRI

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https://www.readbyqxmd.com/read/29682403/novel-biomarkers-of-physical-activity-maintenance-in-midlife-women-preliminary-investigation
#1
Kelly A Bosak, Vlad B Papa, Morgan G Brucks, Cary R Savage, Joseph E Donnelly, Laura E Martin
The precision health initiative is leading the discovery of novel biomarkers as important indicators of biological processes or responses to behavior, such as physical activity. Neural biomarkers identified by magnetic resonance imaging (MRI) hold promise to inform future research, and ultimately, for transfer to the clinical setting to optimize health outcomes. This study investigated resting-state and functional brain biomarkers between midlife women who were maintaining physical activity in accordance with the current national guidelines and previously acquired age-matched sedentary controls...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29681927/altered-structural-and-functional-connectivity-of-juvenile-myoclonic-epilepsy-an-fmri-study
#2
Chengqing Zhong, Rong Liu, Cheng Luo, Sisi Jiang, Li Dong, Rui Peng, Fuqiang Guo, Pu Wang
The aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI). High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patients with JME and in 24 control subjects. A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV). Then, the observed structural and FCs were associated with the clinical manifestations...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29677346/reduced-functional-and-anatomic-interhemispheric-homotopic-connectivity-in-primary-open-angle-glaucoma-a-combined-resting-state-fmri-and-dti-study
#3
Qian Wang, Weiwei Chen, Huaizhou Wang, Xun Zhang, Xiaoxia Qu, Ying Wang, Ting Li, Ningli Wang, Junfang Xian
Purpose: To investigate if abnormal interhemispheric homotopic functional connectivity were accompanied by corresponding anatomic connectivity changes in primary open-angle glaucoma (POAG) patients, and to relate connectivity changes with retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) thickness. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were performed in 16 POAG patients and 19 healthy controls...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29675389/altered-intrinsic-functional-connectivity-of-the-primary-visual-cortex-in-youth-patients-with-comitant-exotropia-a-resting-state-fmri-study
#4
Pei-Wen Zhu, Xin Huang, Lei Ye, Nan Jiang, Yu-Lin Zhong, Qing Yuan, Fu-Qing Zhou, Yi Shao
AIM: To evaluate the differences in the functional connectivity (FC) of the primary visual cortex (V1) between the youth comitant exotropia (CE) patients and health subjects using resting functional magnetic resonance imaging (fMRI) data. METHODS: Totally, 32 CEs (25 males and 7 females) and 32 healthy control subjects (HCs) (25 males and 7 females) were enrolled in the study and underwent the MRI scanning. Two-sample t -test was used to examine differences in FC maps between the CE patients and HCs...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29674739/spatial-reversal-learning-defect-coincides-with-hypersynchronous-telencephalic-bold-functional-connectivity-in-app-nl-f-nl-f-knock-in-mice
#5
Disha Shah, Amira Latif-Hernandez, Bart De Strooper, Takashi Saito, Takaomi Saido, Marleen Verhoye, Rudi D'Hooge, Annemie Van der Linden
Amyloid pathology occurs early in Alzheimer's disease (AD), and has therefore been the focus of numerous studies. Transgenic mouse models have been instrumental to study amyloidosis, but observations might have been confounded by APP-overexpression artifacts. The current study investigated early functional defects in an APP knock-in mouse model, which allows assessing the effects of pathological amyloid-beta (Aβ) without interference of APP-artifacts. Female APPNL/NL knock-in mice of 3 and 7 months old were compared to age-matched APPNL-F/NL-F mice with increased Aβ42/40 ratio and initial Aβ-plaque deposition around 6 months of age...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674194/resting-state-functional-connectivity-in-children-born-from-gestations-complicated-by-preeclampsia-a-pilot-study-cohort
#6
Lauren E Mak, B Anne Croy, Vanessa Kay, James N Reynolds, Matthew T Rätsep, Nils D Forkert, Graeme N Smith, Angelina Paolozza, Patrick W Stroman, Ernesto A Figueiró-Filho
BACKGROUND: Individuals (PE-F1s) born from preeclampsia (PE)-complicated pregnancies have elevated risks for cognitive impairment. Intervals of disturbed maternal plasma angiokines precede clinical signs of PE. We hypothesized pan-blastocyst dysregulation of angiokines underlies altered PE-F1 brain vascular and neurological development. This could alter brain functional connectivity (FC) patterns at rest. MATERIALS AND METHODS: Resting-state functional MRI datasets of ten, matched child pairs (5 boys and 5 girls aged 7-10 years of age) from PE or control pregnancies were available for study...
February 7, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29668850/altered-neocortical-gene-expression-brain-overgrowth-and-functional-over-connectivity-in-chd8-haploinsufficient-mice
#7
Philipp Suetterlin, Shaun Hurley, Conor Mohan, Kimberley L H Riegman, Marco Pagani, Angela Caruso, Jacob Ellegood, Alberto Galbusera, Ivan Crespo-Enriquez, Caterina Michetti, Yohan Yee, Robert Ellingford, Olivier Brock, Alessio Delogu, Philippa Francis-West, Jason P Lerch, Maria Luisa Scattoni, Alessandro Gozzi, Cathy Fernandes, M Albert Basson
Truncating CHD8 mutations are amongst the highest confidence risk factors for autism spectrum disorder (ASD) identified to date. Here, we report that Chd8 heterozygous mice display increased brain size, motor delay, hypertelorism, pronounced hypoactivity, and anomalous responses to social stimuli. Whereas gene expression in the neocortex is only mildly affected at midgestation, over 600 genes are differentially expressed in the early postnatal neocortex. Genes involved in cell adhesion and axon guidance are particularly prominent amongst the downregulated transcripts...
April 13, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29664902/a-general-prediction-model-for-the-detection-of-adhd-and-autism-using-structural-and-functional-mri
#8
Bhaskar Sen, Neil C Borle, Russell Greiner, Matthew R G Brown
This work presents a novel method for learning a model that can diagnose Attention Deficit Hyperactivity Disorder (ADHD), as well as Autism, using structural texture and functional connectivity features obtained from 3-dimensional structural magnetic resonance imaging (MRI) and 4-dimensional resting-state functional magnetic resonance imaging (fMRI) scans of subjects. We explore a series of three learners: (1) The LeFMS learner first extracts features from the structural MRI images using the texture-based filters produced by a sparse autoencoder...
2018: PloS One
https://www.readbyqxmd.com/read/29660513/white-matter-functional-networks-changes-in-patients-with-schizophrenia
#9
REVIEW
Yuchao Jiang, Cheng Luo, Xuan Li, Yingjia Li, Hang Yang, Jianfu Li, Xin Chang, Hechun Li, Huanghao Yang, Jijun Wang, Mingjun Duan, Dezhong Yao
Resting-state functional MRI (rsfMRI) is a useful technique for investigating the functional organization of human gray-matter in neuroscience and neuropsychiatry. Nevertheless, most studies have demonstrated the functional connectivity and/or task-related functional activity in the gray-matter. White-matter functional networks have been investigated in healthy subjects. Schizophrenia has been hypothesized to be a brain disorder involving insufficient or ineffective communication associated with white-matter abnormalities...
April 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29657509/a-tensor-statistical-model-for-quantifying-dynamic-functional-connectivity
#10
Yingying Zhu, Xiaofeng Zhu, Minjeong Kim, Jin Yan, Guorong Wu
Functional connectivity (FC) has been widely investigated in many imaging-based neuroscience and clinical studies. Since functional Magnetic Resonance Image (MRI) signal is just an indirect reflection of brain activity, it is difficult to accurately quantify the FC strength only based on signal correlation. To address this limitation, we propose a learning-based tensor model to derive high sensitivity and specificity connectome biomarkers at the individual level from resting-state fMRI images. First, we propose a learning-based approach to estimate the intrinsic functional connectivity...
June 2017: Information Processing in Medical Imaging: Proceedings of the ... Conference
https://www.readbyqxmd.com/read/29656926/resting-state-cerebral-blood-flow-with-arterial-spin-labeling-mri-in-developing-human-brains
#11
Feng Liu, Yunsuo Duan, Bradley S Peterson, Iris Asllani, Fernando Zelaya, David Lythgoe, Alayar Kangarlu
The development of brain circuits is coupled with changes in neurovascular coupling, which refers to the close relationship between neural activity and cerebral blood flow (CBF). Studying the characteristics of CBF during resting state in developing brain can be a complementary way to understand the functional connectivity of the developing brain. Arterial spin labeling (ASL), as a noninvasive MR technique, is particularly attractive for studying cerebral perfusion in children and even newborns. We have collected pulsed ASL data in resting state for 47 healthy subjects from young children to adolescence (aged from 6 to 20 years old)...
March 24, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29656446/hemodynamic-response-function-hrf-variability-confounds-resting-state-fmri-functional-connectivity
#12
D Rangaprakash, Guo-Rong Wu, Daniele Marinazzo, Xiaoping Hu, Gopikrishna Deshpande
PURPOSE: fMRI is the convolution of the hemodynamic response function (HRF) and unmeasured neural activity. HRF variability (HRFv) across the brain could, in principle, alter functional connectivity (FC) estimates from resting-state fMRI (rs-fMRI). Given that HRFv is driven by both neural and non-neural factors, it is problematic when it confounds FC. However, this aspect has remained largely unexplored even though FC studies have grown exponentially. We hypothesized that HRFv confounds FC estimates in the brain's default-mode-network...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29656321/multi-center-reproducibility-of-structural-diffusion-tensor-and-resting-state-functional-magnetic-resonance-imaging-measures
#13
S Deprez, Michiel B de Ruiter, S Bogaert, R Peeters, J Belderbos, D De Ruysscher, S Schagen, S Sunaert, P Pullens, E Achten
PURPOSE: The aim of this study is to assess multi-center reproducibility and longitudinal consistency of MRI imaging measurements, as part of a phase III longitudinal multi-center study comparing the neurotoxic effect following prophylactic cranial irradiation with hippocampal avoidance (HA-PCI), in comparison with conventional PCI in patients with small-cell lung cancer. METHODS: Harmonized MRI acquisition protocols from six participating sites and two different vendors were compared using both physical and human phantoms...
April 14, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29644156/group-a-streptococcal-pyomyositis-in-a-previously-healthy-six-year-old-girl
#14
Daniel Tawfik, Wendy L Hobson
A six-year-old previously healthy girl was seen in an outpatient pediatric clinic in the western United States for thigh pain. The pain was accompanied by an initial fever and was most severe after periods of prolonged rest. During the evaluation, her exam rapidly progressed with severe episodic pain and tenderness of the right anteromedial thigh. Magnetic resonance imaging (MRI) demonstrated signal enhancement at the insertion of the right obturator externus muscle. Blood culture was positive for Group A Streptococcus...
February 8, 2018: Curēus
https://www.readbyqxmd.com/read/29628271/functional-network-abnormalities-consistent-with-behavioral-profile-in-autism-spectrum-disorder
#15
René Besseling, Rolf Lamerichs, Britt Michels, Stephan Heunis, Anton de Louw, Anton Tijhuis, Jan Bergmans, Bert Aldenkamp
Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which the severity of symptoms varies over subjects. The iCAPs model (innovation-driven co-activation patterns) is a recently developed spatio-temporal model to describe fMRI data. In this study, the iCAPs model was employed to find functional imaging biomarkers for ASD in resting-state fMRI data. MRI data from 125 ASD patients and 243 healthy controls was selected from the online ABIDE data repository. Following standard fMRI preprocessing steps, the iCAP patterns were fitted to the data to obtain network time series...
February 21, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29628269/cerebellar-abnormalities-in-first-episode-drug-naive-schizophrenia-at-rest
#16
Wenbin Guo, Fengyu Zhang, Feng Liu, Jindong Chen, Renrong Wu, Danny Q Chen, Zhikun Zhang, Jinguo Zhai, Jingping Zhao
The cerebellum plays a crucial role in higher cortical functions through a cerebellar-cerebral circuit. However, the specific mechanisms through which the cerebellum contributes to the neurobiology of schizophrenia remain unclear. Forty-nine first-episode, drug-naive patients with schizophrenia and 50 healthy controls underwent structural and resting-state functional magnetic resonance imaging (rs-fMRI). The MRI data were analyzed using voxel-based morphometry, amplitude of low-frequency fluctuations (ALFF), cerebellum homogeneity (CH), and seed-based functional connectivity (FC)...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29628186/amygdala-functional-and-structural-connectivity-predicts-individual-risk-tolerance
#17
Wi Hoon Jung, Sangil Lee, Caryn Lerman, Joseph W Kable
Risk tolerance, the degree to which an individual is willing to tolerate risk in order to achieve a greater expected return, influences a variety of financial choices and health behaviors. Here we identify intrinsic neural markers for risk tolerance in a large (n = 108) multimodal imaging dataset of healthy young adults, which includes anatomical and resting-state functional MRI and diffusion tensor imaging. Using a data-driven approach, we found that higher risk tolerance was most strongly associated with greater global functional connectivity (node strength) of and greater gray matter volume in bilateral amygdala...
March 28, 2018: Neuron
https://www.readbyqxmd.com/read/29627940/effects-of-motor-rehabilitation-on-mobility-and-brain-plasticity-in-multiple-sclerosis-a-structural-and-functional-mri-study
#18
Eleonora Tavazzi, Niels Bergsland, Davide Cattaneo, Elisa Gervasoni, Maria Marcella Laganà, Ottavia Dipasquale, Cristina Grosso, Francesca Lea Saibene, Francesca Baglio, Marco Rovaris
BACKGROUND: Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery. OBJECTIVE: To study functional and structural brain changes induced by gait rehabilitation. METHODS: We enrolled MS inpatients (EDSS 4.5-6.5) undergoing a 4-week neurorehabilitation. Several clinical measures were obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS)...
April 7, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29626649/random-forest-based-classification-of-alcohol-dependence-patients-and-healthy-controls-using-resting-state-mri
#19
Xi Zhu, Xiaofei Du, Mike Kerich, Falk W Lohoff, Reza Momenan
Currently, classification of alcohol use disorder (AUD) is made on clinical grounds; however, robust evidence shows that chronic alcohol use leads to neurochemical and neurocircuitry adaptations. Identifications of the neuronal networks that are affected by alcohol would provide a more systematic way of diagnosis and provide novel insights into the pathophysiology of AUD. In this study, we identified network-level brain features of AUD, and further quantified resting-state within-network, and between-network connectivity features in a multivariate fashion that are classifying AUD, thus providing additional information about how each network contributes to alcoholism...
April 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29618564/postnatal-zika-virus-infection-is-associated-with-persistent-abnormalities-in-brain-structure-function-and-behavior-in-infant-macaques
#20
Maud Mavigner, Jessica Raper, Zsofia Kovacs-Balint, Sanjeev Gumber, Justin T O'Neal, Siddhartha K Bhaumik, Xiaodong Zhang, Jakob Habib, Cameron Mattingly, Circe E McDonald, Victoria Avanzato, Mark W Burke, Diogo M Magnani, Varian K Bailey, David I Watkins, Thomas H Vanderford, Damien Fair, Eric Earl, Eric Feczko, Martin Styner, Sherrie M Jean, Joyce K Cohen, Guido Silvestri, R Paul Johnson, David H O'Connor, Jens Wrammert, Mehul S Suthar, Mar M Sanchez, Maria C Alvarado, Ann Chahroudi
The Zika virus (ZIKV) epidemic is associated with fetal brain lesions and other serious birth defects classified as congenital ZIKV syndrome. Postnatal ZIKV infection in infants and children has been reported; however, data on brain anatomy, function, and behavioral outcomes following infection are absent. We show that postnatal ZIKV infection of infant rhesus macaques (RMs) results in persistent structural and functional alterations of the central nervous system compared to age-matched controls. We demonstrate ZIKV lymphoid tropism and neurotropism in infant RMs and histopathologic abnormalities in the peripheral and central nervous systems including inflammatory infiltrates, astrogliosis, and Wallerian degeneration...
April 4, 2018: Science Translational Medicine
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