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Resting state MRI

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https://www.readbyqxmd.com/read/28817956/the-role-of-intrinsic-brain-functional-connectivity-in-vulnerability-and-resilience-to-bipolar-disorder
#1
Gaelle E Doucet, Danielle S Bassett, Nailin Yao, David C Glahn, Sophia Frangou
OBJECTIVE: Bipolar disorder is a heritable disorder characterized by mood dysregulation associated with brain functional dysconnectivity. Previous research has focused on the detection of risk- and disease-associated dysconnectivity in individuals with bipolar disorder and their first-degree relatives. The present study seeks to identify adaptive brain connectivity features associated with resilience, defined here as avoidance of illness or delayed illness onset in unaffected siblings of patients with bipolar disorder...
August 18, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28817662/single-scan-rest-stress-imaging-with-99mtc-sestamibi-and-cadmium-zinc-telluride-based-spect-for-hyperemic-flow-quantification-a-feasibility-study-evaluated-with-cardiac-magnetic-resonance-imaging
#2
Yu-Hua Dean Fang, Yuan-Chang Liu, Kung-Chu Ho, Feng-Cheng Kuo, Ching-Fang Yang, Tzu-Chen Yen, I-Chang Hsieh
INTRODUCTION: We aimed to evaluate whether the hyperemic myocardial blood flow (MBF) can be estimated using cadmium zinc telluride (CZT)-based single-photon emission computed tomography (SPECT) cameras with a single, rapid rest/stress dynamic scan. Dynamic contrast-enhanced (DCE) cardiac magnetic resonance imaging (MRI) was used as a reference modality for flow measurement. MATERIALS AND METHODS: The proposed protocol included both the rest and stress acquisitions within a 24-min scan...
2017: PloS One
https://www.readbyqxmd.com/read/28816791/resting-state-functional-connectivity-in-the-human-connectome-project-current-status-and-relevance-to-understanding-psychopathology
#3
Deanna M Barch
A key tenet of modern psychiatry is that psychiatric disorders arise from abnormalities in brain circuits that support human behavior. Our ability to examine hypotheses around circuit-level abnormalities in psychiatric disorders has been made possible by advances in human neuroimaging technologies. These advances have provided the basis for recent efforts to develop a more complex understanding of the function of brain circuits in health and of their relationship to behavior-providing, in turn, a foundation for our understanding of how disruptions in such circuits contribute to the development of psychiatric disorders...
August 16, 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/28816098/global-fluctuations-of-cerebral-blood-flow-indicate-a-global-brain-network-independent-of-systemic-factors
#4
Li Zhao, David C Alsop, John A Detre, Weiying Dai
Global synchronization across specialized brain networks is a common feature of network models and in-vivo electrical measurements. Although the imaging of specialized brain networks with blood oxygenation sensitive resting state functional magnetic resonance imaging (rsfMRI) has enabled detailed study of regional networks, the study of globally correlated fluctuations with rsfMRI is confounded by spurious contributions to the global signal from systemic physiologic factors and other noise sources. Here we use an alternative rsfMRI method, arterial spin labeled perfusion MRI, to characterize global correlations and their relationship to correlations and anti-correlations between regional networks...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28815863/decoding-fmri-events-in-sensorimotor-motor-network-using-sparse-paradigm-free-mapping-and-activation-likelihood-estimates
#5
Francisca M Tan, César Caballero-Gaudes, Karen J Mullinger, Siu-Yeung Cho, Yaping Zhang, Ian L Dryden, Susan T Francis, Penny A Gowland
Most functional MRI (fMRI) studies map task-driven brain activity using a block or event-related paradigm. Sparse paradigm free mapping (SPFM) can detect the onset and spatial distribution of BOLD events in the brain without prior timing information, but relating the detected events to brain function remains a challenge. In this study, we developed a decoding method for SPFM using a coordinate-based meta-analysis method of activation likelihood estimation (ALE). We defined meta-maps of statistically significant ALE values that correspond to types of events and calculated a summation overlap between the normalized meta-maps and SPFM maps...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28811179/lateral-frontal-pole-and-relational-processing-activation-patterns-and-connectivity-profile
#6
Bart Hartogsveld, Bob Bramson, Suhas Vijayakumar, A Dilene van Campen, José P Marques, Karin Roelofs, Ivan Toni, Harold Bekkering, Rogier B Mars
The functional contribution of the lateral prefrontal cortex to behavior has been discussed with reference to several higher-order cognitive domains. In a separate line of research, recent studies have focused on the anatomical organization of this part of the brain. However, these different approaches are rarely combined. Here, we combine previous work using anatomical connectivity that identified a lateral subdivision of the human frontal pole and work that suggested a general role for rostrolateral prefrontal cortex in processing higher-order relations, irrespective of the type of information...
August 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28790831/spontaneous-alterations-of-regional-brain-activity-in-patients-with-adult-generalized-anxiety-disorder
#7
Likun Xia, Shumei Li, Tianyue Wang, Yaping Guo, Lihong Meng, Yunping Feng, Yu Cui, Fan Wang, Jian Ma, Guihua Jiang
OBJECTIVE: We aimed to examine how spontaneous brain activity might be related to the pathophysiology of generalized anxiety disorder (GAD). PATIENTS AND METHODS: Using resting-state functional MRI, we examined spontaneous regional brain activity in 31 GAD patients (mean age, 36.87±9.16 years) and 36 healthy control participants (mean age, 39.53±8.83 years) matched for age, education, and sex from December 2014 to October 2015. We performed a two-sample t-test on the voxel-based analysis of the regional homogeneity (ReHo) maps...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28783763/mapping-altered-brain-connectivity-and-its-clinical-associations-in-adult-moyamoya-disease-a-resting-state-functional-mri-study
#8
Ken Kazumata, Khin Khin Tha, Haruto Uchino, Masaki Ito, Naoki Nakayama, Takeo Abumiya
Detection of subtle ischemic injuries in moyamoya disease may enable optimization of timing of revascularization surgery, and could potentially improve functional outcomes. Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to study functional organization of the brain, but it remains unclear whether rs-fMRI could elucidate distinct characteristics in moyamoya disease. Here, we aimed to determine changes in a conventional rs-fMRI measure and analyze any associations with clinical symptoms and cerebral hemodynamics...
2017: PloS One
https://www.readbyqxmd.com/read/28782681/a-bayesian-spatial-model-for-neuroimaging-data-based-on-biologically-informed-basis-functions
#9
Ismael Huertas, Marianne Oldehinkel, Erik S B van Oort, David Garcia-Solis, Pablo Mir, Christian F Beckmann, Andre F Marquand
The dominant approach to neuroimaging data analysis employs the voxel as the unit of computation. While convenient, voxels lack biological meaning and their size is arbitrarily determined by the resolution of the image. Here, we propose a multivariate spatial model in which neuroimaging data is characterized as a linearly weighted combination of multiscale basis functions which map onto underlying brain nuclei or networks or nuclei. In this model, the elementary building blocks are derived to reflect the functional anatomy of the brain during the resting state...
August 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28782373/correlating-resting-state-functional-mri-connectivity-by-independent-component-analysis-based-epileptogenic-zones-with-intracranial-eeg-localized-seizure-onset-zones-and-surgical-outcomes-in-prospective-pediatric-intractable-epilepsy-study
#10
Varina Boerwinkle, Deepankar Mohanty, Stephen Foldes, Danielle Guffey, Charles G Minard, Lucia Mirea, Aditya Vedantam, Jeffery S Raskin, Sandi Lam, Margaret Bond, P David Adelson, Angus A Wilfong, Daniel J Curry
OBJECTIVE: Prospective investigation determining agreement between the epileptogenic zone(s) (EZ) localization by resting state functional MRI (rs-fMRI) and the seizure onset zone(s) (SOZ) identified by intracranial EEG (ic-EEG) using novel differentiating and ranking criteria of rs-fMRI abnormal independent components in a consecutive heterogeneous pediatric intractable epilepsy population prospectively was conducted. METHODS: The EZ criteria were developed from an initial cohort of 350 patients evaluated for epilepsy surgery over a 3-year period...
August 7, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28774705/serotonin-transporter-gene-promoter-methylation-in-peripheral-cells-in-healthy-adults-neural-correlates-and-tissue-specificity
#11
Elmira Ismaylova, Jessica Di Sante, Moshe Szyf, Zsofia Nemoda, Wei-Jo Yu, Florence B Pomares, Gustavo Turecki, Gabriella Gobbi, Frank Vitaro, Richard E Tremblay, Linda Booij
Early adversity can influence gene expression via epigenetic mechanisms, including DNA methylation. Peripheral tissues are essential in psychiatric epigenetics, as methylation generally cannot be assessed in the living human brain. Several magnetic resonance imaging (MRI) studies show associations of peripheral serotonin transporter gene (SLC6A4) methylation with function and/or structure of frontal-limbic circuits and brain's resting-state. Commonly used samples are derived from blood, saliva or buccal cells...
July 31, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28771482/uncoupling-protein-2-haplotype-does-not-affect-human-brain-structure-and-function-in-a-sample-of-community-dwelling-older-adults
#12
Verena Heise, Enikő Zsoldos, Sana Suri, Claire Sexton, Anya Topiwala, Nicola Filippini, Abda Mahmood, Charlotte L Allan, Archana Singh-Manoux, Mika Kivimäki, Clare E Mackay, Klaus P Ebmeier
Uncoupling protein 2 (UCP2) is a mitochondrial membrane protein that plays a role in uncoupling electron transport from adenosine triphosphate (ATP) formation. Polymorphisms of the UCP2 gene in humans affect protein expression and function and have been linked to survival into old age. Since UCP2 is expressed in several brain regions, we investigated in this study whether UCP2 polymorphisms might 1) affect occurrence of neurodegenerative or mental health disorders and 2) affect measures of brain structure and function...
2017: PloS One
https://www.readbyqxmd.com/read/28768849/brain-imaging-in-myotonic-dystrophy-type-1-a-systematic-review
#13
REVIEW
Kees Okkersen, Darren G Monckton, Nhu Le, Anil M Tuladhar, Joost Raaphorst, Baziel G M van Engelen
OBJECTIVE: To systematically review brain imaging studies in myotonic dystrophy type 1 (DM1). METHODS: We searched Embase (index period 1974-2016) and MEDLINE (index period 1946-2016) for studies in patients with DM1 using MRI, magnetic resonance spectroscopy (MRS), functional MRI (fMRI), CT, ultrasound, PET, or SPECT. From 81 studies, we extracted clinical characteristics, primary outcomes, clinical-genetic correlations, and information on potential risk of bias...
August 2, 2017: Neurology
https://www.readbyqxmd.com/read/28763447/braph-a-graph-theory-software-for-the-analysis-of-brain-connectivity
#14
Mite Mijalkov, Ehsan Kakaei, Joana B Pereira, Eric Westman, Giovanni Volpe
The brain is a large-scale complex network whose workings rely on the interaction between its various regions. In the past few years, the organization of the human brain network has been studied extensively using concepts from graph theory, where the brain is represented as a set of nodes connected by edges. This representation of the brain as a connectome can be used to assess important measures that reflect its topological architecture. We have developed a freeware MatLab-based software (BRAPH-BRain Analysis using graPH theory) for connectivity analysis of brain networks derived from structural magnetic resonance imaging (MRI), functional MRI (fMRI), positron emission tomography (PET) and electroencephalogram (EEG) data...
2017: PloS One
https://www.readbyqxmd.com/read/28760982/low-frequency-hippocampal-cortical-activity-drives-brain-wide-resting-state-functional-mri-connectivity
#15
Russell W Chan, Alex T L Leong, Leon C Ho, Patrick P Gao, Eddie C Wong, Celia M Dong, Xunda Wang, Jufang He, Ying-Shing Chan, Lee Wei Lim, Ed X Wu
The hippocampus, including the dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low-frequency activity in hippocampal-cortical pathways contributes to brain-wide resting-state connectivity to integrate sensory information. Using optogenetic stimulation and brain-wide fMRI and resting-state fMRI (rsfMRI), we determined the large-scale effects of spatiotemporal-specific downstream propagation of hippocampal activity. Low-frequency (1 Hz), but not high-frequency (40 Hz), stimulation of dDG excitatory neurons evoked robust cortical and subcortical brain-wide fMRI responses...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28759710/functional-integrity-in-children-with-anoxic-brain-injury-from-drowning
#16
Mariam Ishaque, Janessa H Manning, Mary D Woolsey, Crystal G Franklin, Elizabeth W Tullis, Christian F Beckmann, Peter T Fox
Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and chronically. Structural neuroimaging modalities (CT and MRI) have been of limited clinical value. Here, we tested the utility of resting-state functional MRI (rs-fMRI) for assessing brain functional integrity in this population...
July 31, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28757305/precision-functional-mapping-of-individual-human-brains
#17
Evan M Gordon, Timothy O Laumann, Adrian W Gilmore, Dillan J Newbold, Deanna J Greene, Jeffrey J Berg, Mario Ortega, Catherine Hoyt-Drazen, Caterina Gratton, Haoxin Sun, Jacqueline M Hampton, Rebecca S Coalson, Annie L Nguyen, Kathleen B McDermott, Joshua S Shimony, Abraham Z Snyder, Bradley L Schlaggar, Steven E Petersen, Steven M Nelson, Nico U F Dosenbach
Human functional MRI (fMRI) research primarily focuses on analyzing data averaged across groups, which limits the detail, specificity, and clinical utility of fMRI resting-state functional connectivity (RSFC) and task-activation maps. To push our understanding of functional brain organization to the level of individual humans, we assembled a novel MRI dataset containing 5 hr of RSFC data, 6 hr of task fMRI, multiple structural MRIs, and neuropsychological tests from each of ten adults. Using these data, we generated ten high-fidelity, individual-specific functional connectomes...
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28756739/neuroanatomical-correlates-of-donating-behavior-in-middle-childhood
#18
Andrea Wildeboer, Sandra Thijssen, Ryan L Muetzel, Marian J Bakermans-Kranenburg, Henning Tiemeier, Tonya White, Marinus H Van IJzendoorn
The neurobiological correlates of prosocial behavior are largely unknown. We examined brain structure and functional connectivity correlates of donating to a charity, a specific, costly, form of prosocial behavior. In 163 children, donating was measured using a promotional clip for a charity including a call for donations. Children could decide privately whether and how much they wanted to donate from money they had received earlier. Whole brain structural MRI scans were obtained to study associations between cortical thickness and donating behavior...
July 31, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28755988/acute-affective-reactivity-and-quality-of-life-in-older-adults-with-amnestic-mild-cognitive-impairment-a-functional-mri-study
#19
Ping Ren, Kathi L Heffner, Alanna Jacobs, Feng Lin
OBJECTIVES: Poor quality of life (QoL) is a major concern among older adults with amnestic mild cognitive impairment (MCI). Maladaptive affective regulation and its relevant frontal dysfunction that are often observed in older adults with MCI may provide an insight into the understanding of their QoL. METHODS: In this case-controlled study, participants (MCI patients, N = 18; healthy comparisons [HC], N = 21) completed cognitive tasks, and underwent resting-state functional magnetic resonance imaging (rs-fMRI) immediately before and after the tasks...
June 27, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28751860/pseudo-bootstrap-network-analysis-an-application-in-functional-connectivity-fingerprinting
#20
Hu Cheng, Ao Li, Andrea A Koenigsberger, Chunfeng Huang, Yang Wang, Jinhua Sheng, Sharlene D Newman
Brain parcellation divides the brain's spatial domain into small regions, which are represented by nodes within the network analysis framework. While template-based parcellations are widely used, the parcels on the template do not necessarily match individual's functional nodes. A new method is developed to overcome the inconsistent network analysis results by by-passing the difficulties of parcellating the brain into functionally meaningful areas. First, roughly equal-sized parcellations are obtained. Second, these random parcellations are applied to individual subjects multiple times and a pseudo-bootstrap (PBS) of the network is obtained for statistical inferences...
2017: Frontiers in Human Neuroscience
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