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https://www.readbyqxmd.com/read/29678879/potassium-is-a-trigger-for-conformational-change-in-the-fusion-spike-of-an-enveloped-rna-virus
#1
Emma K Punch, Samantha Hover, Henry Tw Blest, Jack Fuller, Roger Hewson, Juan Fontana, Jamel Mankouri, John N Barr
Many enveloped viruses enter cells through the endocytic network, from which they must subsequently escape through fusion of viral and endosomal membranes. This membrane fusion is mediated by virus-encoded spikes that respond to the changing endosomal environment, which triggers conformational change in the spike that initiate the fusion process. Several fusion triggers have been identified and include pH, membrane composition and endosome-resident proteins and these cues dictate when and where viral fusion occurs...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29672075/the-telephone-effect-overcoming-initiation-deficits-in-two-settings
#2
Kayci L Vickers, Michael E Keesler, Kelli S Williams, Jeremy Y Charles, Roy H Hamilton
PURPOSE: Disorders of motivation substantially impair an individual's ability to communicate with their families, therapists, and doctors. One method of overcoming initiation deficits is by utilizing the telephone effect, which is the ability for individuals with severe motivation deficits to communicate more readily when speaking on a telephone. However, little is available in the extant literature on how this effect works or how best to integrate this into patient care. This article aims to provide the first report of a proposed mechanism underlying the telephone effect and the first published procedures for eliciting this effect...
April 19, 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/29670616/overactivity-of-alternative-pathway-convertases-in-patients-with-complement-mediated-renal-diseases
#3
Marloes A H M Michels, Nicole C A J van de Kar, Marcin Okrój, Anna M Blom, Sanne A W van Kraaij, Elena B Volokhina, Lambertus P W J van den Heuvel
Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). C3 nephritic factors (C3NeF) play an important role in C3G pathogenesis by stabilizing the key enzymatic complex of complement, the C3 convertase. However, the reliability of assays detecting these autoantibodies is limited. Therefore, in this study, we validated and optimized a prototype hemolytic method for robust detection and characterization of factors causing convertase overactivity in large patient cohorts...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29667169/expression-of-scavenger-receptor-marco-defines-a-targetable-tumor-associated-macrophage-subset-in-non-small-cell-lung-cancer
#4
Linnéa La Fleur, Vanessa F Boura, Andrey Alexeyenko, Anders Berglund, Victor Pontén, Johanna Sm Mattsson, Dijana Djureinovic, Johan Persson, Hans Brunnström, Johan Isaksson, Eva Brandén, Hirsh Koyi, Patrick Micke, Mikael Ci Karlsson, Johan Botling
Tumor-associated macrophages (TAMs) are attractive targets for immunotherapy. Recently, studies in animal models showed that treatment with an anti-TAM antibody directed against the scavenger receptor MARCO resulted in suppression of tumor growth and metastatic dissemination. Here we investigated the expression of MARCO in relation to other macrophage markers and immune pathways in a non-small cell lung cancer (NSCLC) cohort (n=352). MARCO, CD68, CD163, MSR1 and programmed death ligand-1 (PD-L1) were analyzed by immunohistochemistry and immunofluorescence, and associations to other immune cells and regulatory pathways were studied in a subset of cases (n=199) with available RNA-seq data...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29666797/development-and-implementation-of-a-perianesthetic-safety-checklist-in-a-veterinary-university-small-animal-teaching-hospital
#5
Gwennaëlle Menoud, Shannon Axiak Flammer, Claudia Spadavecchia, Mathieu Raillard
Introduction: The use of a surgical safety checklist is recommended by the World Health Organization and is associated with advantages: improved communication and reduced complications and mortality. Adapting checklists to the environment in which they are used improves their efficiency, but their implementation can be challenging. The aim of this study was to develop and implement a perianesthetic safety checklist for a small animal hospital. Materials and methods: A panel of eight anesthesia diplomates and seven residents and doctoral students were gathered...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29652043/-the-hardware-techniques-for-the-restoration-of-the-gait-stereotype-in-the-patients-following-total-hip-replacement-the-personalized-approach
#6
E S Koneva, K V Lyadov, T V Shapovalenko, E V Zhukova, V G Polushkin
BACKGROUND: total hip replacement has long ago become the «golden standard» for the treatment of dysplastic coxarthrosis in thousands of the patients receiving it every year. In the meantime, the analysis of the specialized literature gives evidence of the lack of a systematic and personified approach to the rehabilitation treatment. AIM: The objective of the present study was to improve medical rehabilitation of the patients following the total hip replacement and to develop the personalized programs for walking modality reconstruction taking into consideration the age and the body weight of the patients...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29644383/optimizing-resident-operative-self-confidence-through-competency-based-surgical-education-modules-are-we-there-yet
#7
Roxana Geoffrion, Nicole A Koenig, May S Sanaee, Terry Lee, Nicole J Todd
INTRODUCTION AND HYPOTHESIS: Self-confidence is the belief in one's ability to perform and can be enhanced by training. Surgical education should aim to optimize trainee confidence. We designed three procedure-specific competency-based modules to teach vaginal hysterectomy (VH), anterior (AR) and posterior repair (PR) to novice gynecology residents. We hypothesized each module would improve self-confidence and satisfaction during index procedure performance in the operating room. METHODS: This was an ancillary analysis of a larger randomized-controlled trial of gynecologic educational interventions...
April 11, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29643214/anemone-bleaching-increases-the-metabolic-demands-of-symbiont-anemonefish
#8
Tommy Norin, Suzanne C Mills, Amélie Crespel, Daphne Cortese, Shaun S Killen, Ricardo Beldade
Increased ocean temperatures are causing mass bleaching of anemones and corals in the tropics worldwide. While such heat-induced loss of algal symbionts (zooxanthellae) directly affects anemones and corals physiologically, this damage may also cascade on to other animal symbionts. Metabolic rate is an integrative physiological trait shown to relate to various aspects of organismal performance, behaviour and locomotor capacity, and also shows plasticity during exposure to acute and chronic stressors. As climate warming is expected to affect the physiology, behaviour and life history of animals, including ectotherms such as fish, we measured if residing in bleached versus unbleached sea anemones ( Heteractis magnifica ) affected the standard (i...
April 11, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29628572/impact-of-targeted-preoperative-optimization-on-clinical-outcome-in-emergency-abdominal-surgeries-a-prospective-randomized-trial
#9
Ashish Sethi, Miltan Debbarma, Neeraj Narang, Anudeep Saxena, Mamta Mahobia, Gaurav Singh Tomar
Background: Perforation peritonitis continues to be one of the most common surgical emergencies that need a surgical intervention most of the times. Anesthesiologists are invariably involved in managing such cases efficiently in perioperative period. Aims: The assessment and evaluation of Acute Physiology and Chronic Health Evaluation II (APACHE II) score at presentation and 24 h after goal-directed optimization, administration of empirical broad-spectrum antibiotics, and definitive source control postoperatively...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29621716/assessment-of-dermal-exposure-to-halogenated-flame-retardants-comparison-using-direct-measurements-from-hand-wipes-with-an-indirect-estimation-from-settled-dust-concentrations
#10
Joo Hui Tay, Ulla Sellström, Eleni Papadopoulou, Juan Antonio Padilla-Sánchez, Line Småstuen Haug, Cynthia A de Wit
There are few studies estimating dermal exposure to halogenated flame retardants in adults. To fill this gap, sixty-one hand wipe samples were collected from a Norwegian adult cohort using gauze pads immersed in isopropanol. BDE-47, BDE-209, bis(2‑ethyl‑hexyl)‑3,4,5,6‑tetrabromophthalate (BEH-TEBP) and decabromodiphenylethane (DBDPE) were the most frequently detected chemicals. The highest median mass in hand wipes was that of sumEHFR (570 ng), followed by sumHBCDD (180 ng) and sumPBDE (2.9 ng)...
April 2, 2018: Environment International
https://www.readbyqxmd.com/read/29615354/improved-access-to-health-care-in-massachusetts-after-2006-massachusetts-healthcare-reform-law-is-associated-with-a-significant-decrease-in-mortality-among-vascular-surgery-patients
#11
Mohammad H Eslami, Katherine Moll Reitz, Denis V Rybin, Gheorghe Doros, Alik Farber
BACKGROUND: Access to medical care, by adequate insurance coverage, has a direct impact on outcomes for patients undergoing vascular procedures. We evaluated in-hospital mortality for patients undergoing index vascular procedures before and after the Massachusetts Healthcare Reform Law (MHRL) in 2006, which mandated insurance for all Massachusetts residents, both in Massachusetts and throughout the United States. METHODS: The National Inpatient Sample was queried to identify patients undergoing interventions for peripheral arterial disease, carotid artery stenosis, and abdominal aortic aneurysms based on International Classification of Diseases, Ninth Revision, Clinical Modification procedural and diagnostic codes...
March 31, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29609893/evaluation-of-the-characteristics-of-a-workplace-assessment-form-to-assess-entrustable-professional-activities-epas-in-an-undergraduate-surgery-core-clerkship
#12
Vernon R Curran, Diana Deacon, Henry Schulz, Katherine Stringer, Craig N Stone, Norah Duggan, Heidi Coombs-Thorne
OBJECTIVE: Entrustable Professional Activities (EPAs) are explicit, directly observable tasks requiring the demonstration of specific knowledge, skills, and behaviors that learners are expected to perform without direct supervision once they have gained sufficient competence. Undergraduate level implementation of EPAs is relatively new. We examined the characteristics of a workplace assessment form (clinic card) as part of a formative programmatic assessment process of EPAs for a core undergraduate surgery rotation...
March 30, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29607335/using-newly-deceased-patients-in-teaching-clinical-skills-its-ethical-and-educational-challenges
#13
Mahboobeh Saber, Seyed Ali Enjoo, Ali Mahboudi, Seyed Ziaadin Tabei
Introduction: The newly deceased patients have long been used in medical schools to teach clinical skills without any challenges as it helps to train skilled doctors. Nowadays, the use of moulages and simulators are common in teaching clinical skills since these tools provide the opportunity for frequent practice without any pain and injury. There are specific procedures which still require the use of cadavers. However, the increased significance of patient rights has generally challenged the practicality of using the deceased bodies for this purpose...
April 2018: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/29606163/the-impact-of-isolation-on-healthcare-worker-contact-and-compliance-with-infection-control-practices-in-nursing-homes
#14
Lisa Pineles, Chris Petruccelli, Eli N Perencevich, Mary-Claire Roghmann, Kalpana Gupta, Jose Cadena, Gio Baracco, Christopher D Pfeiffer, Graeme Forrest, Suzanne F Bradley, Chris Crnich, Heather Reisinger, Daniel J Morgan
OBJECTIVETo directly observe healthcare workers in a nursing home setting to measure frequency and duration of resident contact and infection prevention behavior as a factor of isolation practiceDESIGNObservational studySETTING AND PARTICIPANTSHealthcare workers in 8 VA nursing homes in Florida, Maryland, Massachusetts, Michigan, Washington, and TexasMETHODSOver a 15-month period, trained research staff without clinical responsibilities on the units observed nursing home resident room activity for 15-30-minute intervals...
April 2, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29606112/risk-factors-for-the-occurrence-of-multidrug-resistant-tuberculosis-among-patients-undergoing-multidrug-resistant-tuberculosis-treatment-in-east-shoa-ethiopia
#15
Fanta Desissa, Tilaye Workineh, Takele Beyene
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is resistant to the two main first-line anti-tuberculosis drugs: rifampicin and isoniazid. It is a major threat to public health worldwide. The objective of this study was to assess the potential risk factors for multidrug-resistant tuberculosis among patients undergoing MDR-TB treatment at two community hospitals in Ethiopia. METHODS: A case-control study design was conducted from February 1, 2016, to April 29, 2016...
April 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29602433/improving-resident-s-skills-in-the-management-of-circulatory-shock-with-a-knowledge-based-e-learning-tool
#16
David Riaño, Francis Real, Jose Ramon Alonso
BACKGROUND: Correct clinical management of circulatory shock in emergency departments (ER) and intensive care units (ICU) is critical. In this context, the transmission of professional skills by means of the practical supervision of real cases at the point of care entails important issues that can be widely overcome with the use of computer knowledge-based e-learning tools. OBJECTIVE: Shock-Instructor is a web-based e-learning tool implementing the already tested training program model (TPM) that uses a knowledge base about the evidence found in the clinical practice guidelines about seven types of shock...
May 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29587578/maternal-sensitivity-in-mother-infant-interactions-in-rio-de-janeiro-brazil
#17
Ana Carla Lima Ribeiro-Accioly, Maria Lucia Seidl-De-Moura, Deise Maria Leal Fernandes Mendes, Judi Mesman
This article reports on a study of maternal sensitivity in 22 primiparous women and their infants from Rio de Janeiro, Brazil. Two semi-structured interviews were conducted, as well as videotaped naturalistic home observations of the dyads. A K-means cluster analysis was performed to examine patterns of risk in relation to maternal sensitivity. The results reveal that compared to the 15 mothers with higher sensitivity scores, the 7 mothers with lower sensitivity scores were characterized by lower educational levels, lower income, lower age, living in a slum, unplanned and unwanted pregnancies, and later onset of prenatal care...
March 28, 2018: Attachment & Human Development
https://www.readbyqxmd.com/read/29584792/risk-factors-for-unfavourable-treatment-outcome-among-new-smear-positive-pulmonary-tuberculosis-cases-in-china
#18
Y Lin, D A Enarson, J Du, R A Dlodlo, C-Y Chiang, I D Rusen
Setting: Three projects of the Fund for Innovative DOTS Expansion through Local Initiatives to Stop TB. Objectives: To assess unfavourable treatment outcomes (UTOs), including failure, died, loss to follow-up (LTFU), transferred out and unknown outcome, and to identify risk factors associated with UTOs. Design: This was a cross-sectional study using routine programme data. Results: Of 30 277 new smear-positive tuberculosis (TB) patients, 4261 (14.1%) had UTOs: 2048 (6.8%) LTFU, 1418 (4.7%) transferred out, 390 (1...
December 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/29581477/metal-behavior-in-the-extremes-of-dynamics
#19
Aleksander Zubelewicz
When the rate of loading is faster than the rate at which material absorbs and converts energy to plastic work and damages, then there is an excess of energy that is partly stored in the material's microstructure and the rest of it triggers micro-dynamic excitations. The additional storage necessitates the development of plastic flow constraints and is directly responsible for the observed dynamic strengthening. At extreme conditions, we find that the micro-excitations contribute to the dynamic behavior. The phenomena are universally observed in metals, frictional materials and polymers...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29579426/prevalence-of-pulmonary-tuberculosis-among-adults-in-selected-slums-of-delhi-city
#20
Rohit Sarin, Vikram Vohra, U K Khalid, Prem Prakash Sharma, Vineet Chadha, M A Sharada
BACKGROUND: A survey was carried out to estimate the point prevalence of bacteriologically positive pulmonary tuberculosis (PTB) among persons ≥15 years of age residing in Jhuggi-Jhopri (JJ) colonies - urban slums in Delhi, India implementing Directly Observed Treatment strategy since 1998. METHODS: Among 12 JJ colonies selected by simple random sampling, persons having persistent cough for ≥2 weeks at the time of the survey or cough of any duration along with history of contact/currently on ant-TB treatment/known HIV positive were subjected to sputum examination - 2 specimens, by smear microscopy for Acid Fast Bacilli and culture for Mycobacterium tuberculosis...
April 2018: Indian Journal of Tuberculosis
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