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eGFR and slope

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https://www.readbyqxmd.com/read/29932293/switching-to-abacavir-versus-use-of-a-nucleoside-sparing-dual-regimen-for-hiv-infected-patients-with-tenofovir-associated-renal-toxicity
#1
J L Casado, C Santiuste, M J Vivancos, M Monsalvo, A Moreno, M J Perez-Elías, J M Del Rey, S Moreno
OBJECTIVES: We investigated the reversibility of tenofovir disoproxil fumarate (TDF)-associated renal decline and tubular dysfunction using different antiretroviral strategies. METHODS: A successive evaluation of renal [estimated glomerular filtration rate (eGFR)] and tubular (phosphataemia, proteinuria, albuminuria, phosphaturia, uricosuria, glycosuria and tubular proteinuria) parameters was performed in 231 patients, before and after switching from TDF to abacavir (n = 60), using dual therapy (n = 49), or continuing the same regimen including TDF (n = 122)...
June 22, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29923234/age-alone-is-not-a-contraindication-to-kidney-donation-outcomes-of-donor-nephrectomy-in-the-elderly
#2
Oscar K Serrano, Kunal Yadav, Ananta Bangdiwala, David M Vock, Ty B Dunn, Erik B Finger, Timothy L Pruett, Arthur J Matas, Raja Kandaswamy
With increasing organ demand, living kidney donation from older donors (>60-years-old) has become more common. Between 1975 and 2014, 3752 donor nephrectomies (DN) were performed at University of Minnesota; 167 (4.5%) were >60-years-old Short- and long-term outcomes were compared between contemporaneous >60-years-old and <60-years-old donors. On univariate analysis, >60-years-old were more likely to have had prior abdominal surgery and hypertension; and less likely to smoke. Baseline estimated glomerular filtration rate (eGFR) was lower in >60-years-old (80 ± 16 vs 101 ± 26 mL/min/1...
June 20, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29887227/time-varying-coefficient-of-determination-to-quantify-the-explanatory-power-of-biomarkers-on-longitudinal-gfr-among-children-with-chronic-kidney-disease
#3
Derek K Ng, Anthony A Portale, Susan L Furth, Bradley A Warady, Alvaro Muñoz
PURPOSE: Coefficients of determination (R2 ) for continuous longitudinal data are typically reported as time constant, if they are reported at all. The widely used mixed model with random intercepts and slopes yields the total outcome variance as a time-varying function. We propose a generalized and intuitive approach based on this variance function to estimate the time-varying predictive power (R2 ) of a variable on outcome levels and changes. METHODS: Using longitudinal estimated glomerular filtration rate (eGFR) from the Chronic Kidney Disease in Children Study, linear mixed models characterized the R2 for two chronic kidney disease (CKD) risk factors measured at baseline: a traditional marker (proteinuria) and a novel marker (fibroblast growth factor 23 [FGF23])...
May 17, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29858211/diabetes-and-trajectories-of-estimated-glomerular-filtration-rate-a-prospective-cohort-analysis-of-the-atherosclerosis-risk-in-communities-study
#4
Bethany Warren, Casey M Rebholz, Yingying Sang, Alexandra K Lee, Josef Coresh, Elizabeth Selvin, Morgan E Grams
OBJECTIVE: Long-term kidney disease trajectories in persons with and without diabetes in a general population are largely uncharacterized. RESEARCH DESIGN AND METHODS: We classified 15,517 participants in the community-based Atherosclerosis Risk in Communities (ARIC) study by diabetes status at baseline (1987-1989; no diabetes, undiagnosed diabetes, and diagnosed diabetes). We used linear mixed models with random intercepts and slopes to quantify estimated glomerular filtration rate (eGFR) trajectories at four visits over 26 years...
June 1, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29798889/incidence-and-progression-of-chronic-kidney-disease-in-black-and-white-individuals-with-type-2-diabetes
#5
Claire Gerber, Xuan Cai, Jungwha Lee, Timothy Craven, Julia Scialla, Nao Souma, Anand Srivastava, Rupal Mehta, Amanda Paluch, Alexander Hodakowski, Rebecca Frazier, Mercedes R Carnethon, Myles Selig Wolf, Tamara Isakova
BACKGROUND AND OBJECTIVES: Type 2 diabetes and associated CKD disproportionately affect blacks. It is uncertain if racial disparities in type 2 diabetes-associated CKD are driven by biologic factors that influence propensity to CKD or by differences in type 2 diabetes care. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a post hoc analysis of 1937 black and 6372 white participants of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial to examine associations of black race with change in eGFR and risks of developing microalbuminuria, macroalbuminuria, incident CKD (eGFR<60 ml/min per 1...
June 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29784612/risk-of-progression-of-nonalbuminuric-ckd-to-end-stage-kidney-disease-in-people-with-diabetes-the-cric-chronic-renal-insufficiency-cohort-study
#6
Digsu N Koye, Dianna J Magliano, Christopher M Reid, Christopher Jepson, Harold I Feldman, William H Herman, Jonathan E Shaw
BACKGROUND: Reduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the frequency with which it progresses to end-stage kidney disease (ESKD) is unknown. STUDY DESIGN: Multicenter prospective cohort study. SETTING & PARTICIPANTS: We included 1,908 participants with diabetes and reduced GFR enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study in the United States...
May 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29677075/measured-glomerular-filtration-rate-after-kidney-donation-no-evidence-of-accelerated-decay
#7
Danielle M Berglund, Lei Zhang, Arthur J Matas, Hassan N Ibrahim
BACKGROUND: The rate of measured GFR change in kidney donors years after donation has not been adequately addressed. Whether this change is accelerated in the setting of 1 kidney is also understudied. METHODS: 214 randomly selected donors underwent serial GFR measurements of nonradioactive iohexol. eGFR at each visit was calculated using the CKD EPI and MDRD study equations. RESULTS: GFR visits were 4.8 ±1.3 years apart and the second occurring 16...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29665081/safety-of-sofosbuvir-based-regimens-after-liver-transplantation-longitudinal-assessment-of-renal-function-in-the-prospective-anrs-co23-cupilt-study
#8
R Anty, G Favre, A Coilly, E Rossignol, P Houssel-Debry, C Duvoux, V De Ledinghen, V Di Martino, V Leroy, S Radenne, N Kamar, V Canva, L D'Alteroche, F Durand, J Dumortier, P Lebray, C Besch, A Tran, C M Canivet, D Botta-Fridlund, H Montialoux, C Moreno, F Conti, C Silvain, P Perré, F Habersetzer, A Abergel, M Debette-Gratien, S Dharancy, V L M Esnault, C Fougerou-Leurent, C Cagnot, A Diallo, A Veislinger, H Danjou, D Samuel, G-P Pageaux, J-C Duclos-Vallée
BACKGROUND: In liver transplant recipients with hepatitis C virus recurrence, there is concern about renal safety of sofosbuvir-based regimens. Changes in serum creatinine or in the estimated glomerular filtration rate (eGFR) under treatment are used to look for possible renal toxicity. However, serum creatinine and eGFR are highly variable. AIM: To analyse renal function trajectory with numerous assays of serum creatinine over a long period of time. METHODS: In a multicentre cohort of 139 patients, the eGFR was obtained from serum creatinine using the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation...
June 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29644066/patterns-of-progression-of-chronic-kidney-disease-at-later-stages
#9
Fernando Caravaca-Fontán, Lilia Azevedo, Enrique Luna, Francisco Caravaca
Background: At later stages of chronic kidney disease (CKD), a pattern of linear and irreversible renal function decline is thought to be the most common. The objective of this study was to describe the characteristics of the different patterns of CKD progression, and to investigate potentially modifiable factors associated with the rate of decline of renal function. Methods: This was a retrospective, observational study in a cohort of adult patients with CKD Stage 4 or 5 not on dialysis...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29573131/achieving-sustained-virologic-response-in-liver-transplant-recipients-with-hepatitis-c-decreases-risk-of-decline-in-renal-function
#10
Sanjaya K Satapathy, Kiran Joglekar, Miklos Z Molnar, Bilal Ali, Humberto C Gonzalez, Jason M Vanatta, James D Eason, Satheesh P Nair
BACKGROUND: The effect of anti-viral therapy (AVT) on kidney function in liver transplant (LT) recipients has not been well described despite known association of hepatitis C virus (HCV) infection with chronic kidney disease (CKD). METHODS: We compared the incidence of CKD, and end-stage renal disease (ESRD) in 204 LT recipients with HCV based on treatment response to AVT. RESULTS: The median eGFR at baseline (3 months post-LT) was similar in the SVR (n=145) and non-SVR group (n=59) (69±21 vs...
March 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29564978/determinants-of-progression-in-early-autosomal-dominant-polycystic-kidney-disease-is-it-blood-pressure-or-renin-angiotensin-aldosterone-system-blockade
#11
Godela M Brosnahan, Kaleab Z Abebe, Charity G Moore, Kyongtae T Bae, William E Braun, Arlene B Chapman, Michael F Flessner, Peter C Harris, Marie C Hogan, Ronald D Perrone, Frederic F Rahbari-Oskoui, Theodore I Steinman, Vicente E Torres, The Halt Pkd Investigators
BACKGROUND: The HALT PKD trial in early autosomal dominant polycystic kidney disease (ADPKD) showed that intensive control of systolic blood pressure to 95-110 mmHg was associated with a 14% slower rate of kidney volume growth compared to standard control. It is unclear whether this result was due to greater blockade of the renin-angiotensin-aldosterone system (RAAS) by allowing the use of higher drug doses in the low blood pressure arm, or due to the lower blood pressure per se. METHODS: In this secondary analysis of HALT PKD Study A, we categorized participants into high and low dose groups based on the median daily equivalent dose of RAAS blocking drugs used after the initial dose titration period...
March 21, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29539614/methods-of-blood-oxygen-level-dependent-magnetic-resonance-imaging-analysis-for-evaluating-renal-oxygenation
#12
Fen Chen, Shulin Li, Dong Sun
Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently been utilized as a noninvasive tool for evaluating renal oxygenation. Several methods have been proposed for analyzing BOLD images. Regional ROI selection is the earliest and most widely used method for BOLD analysis. In the last 20 years, many investigators have used this method to evaluate cortical and medullary oxygenation in patients with ischemic nephropathy, hypertensive nephropathy, diabetic nephropathy, chronic kidney disease (CKD), acute kidney injury and renal allograft rejection...
March 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29539601/renal-function-variability-an-independent-risk-factor-for-graft-loss-and-death-following-kidney-transplantation
#13
Nicole A Pilch, Vinayak Rohan, Vinaya Rao, Patrick D Mauldin, Zemin Su, Derek A Dubay, Thomas A Morinelli, David J Taber
BACKGROUND: Several studies have been performed to evaluate surrogate markers of long-term allograft function in renal transplant recipients. These include serum creatinine, estimated glomerular filtration rate (eGFR), slope of eGFR, and more recently eGFR variability. The aim of this study was to measure eGFR slope while assessing the variability of this slope and if high variability occurring at any time post-transplant was predictive of poorer long-term outcomes in a large cohort of kidney transplant recipients...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29536392/visit-to-visit-blood-pressure-variability-in-children-and-adolescents-with-renal-disease
#14
Hisayo Fujita, Seiji Matsuoka, Midori Awazu
BACKGROUND: Increase in blood pressure (BP) variability (BPV) is associated with cardiovascular events, target organ damage, and arterial stiffness in adults. We previously reported that 24-h BPV may be associated with arterial stiffness and underlie white-coat hypertension (WCH). In this study, we examined whether visit-to-visit variability (VVV) could predict WCH and whether VVV correlated with eGFR, eGFR slope, and albuminuria/proteinuria in children and adolescents with renal diseases...
March 14, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29510922/changes-in-blood-pressure-during-young-adulthood-and-subsequent-kidney-function-decline-findings-from-the-coronary-artery-risk-development-in-young-adulthood-cardia-study
#15
Elaine Ku, Eric Vittinghoff, David R Jacobs, Cora E Lewis, Norrina B Allen, Kirsten Bibbins-Domingo, Michael Shlipak, Holly Kramer, Carmen A Peralta
BACKGROUND: Many studies have focused on the association between a single blood pressure (BP) measurement and risk for adverse outcomes. However, the association of BP trajectories during young adulthood with subsequent decline in kidney function has not been well defined. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: 3,429 participants in the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study enrolled between the ages of 18 and 30 years...
March 3, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29481686/estimated-glomerular-filtration-rate-for-longitudinal-follow-up-of-living-kidney-donors
#16
Marco van Londen, Anthony B Wijninga, Jannieta de Vries, Jan-Stephan F Sanders, Margriet F C de Jong, Robert A Pol, Stefan P Berger, Gerjan Navis, Martin H de Borst
Background: Living kidney donor safety requires reliable long-term follow-up of renal function after donation. The current study aimed to define the precision and accuracy of post-donation estimated glomerular filtration rate (eGFR) slopes compared with measured GFR (mGFR) slopes. Methods: In 349 donors (age 51 ± 10, 54% female), we analysed eGFR according to the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault/body surface area (CG/BSA), creatinine clearance (CrCl) and mGFR (125I-iothalamate) changes from 3 months until 5 years post-donation...
February 22, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29446007/significance-of-early-detection-of-acute-kidney-function-worsening-among-outpatients-having-ckd-using-automatic-calculation-system-for-the-rate-of-egfr-decline
#17
Jun Ito, Hirofumi Kita, Takashi Fujisawa
BACKGROUND: To retard progression of chronic kidney disease (CKD) and reduce end-stage kidney disease, it is important to detect acute kidney function worsening on CKD (AW-CKD) immediately and bring back their kidney functions to baselines by appropriate treatment. However, in general outpatient practice, it is difficult to detect the change in the slope of estimated glomerular filtration rate (eGFR). METHODS: We made automatic calculation system for the rate of eGFR decline (ΔeGFR), and retrospectively observed the situation of AW-CKD among outpatients, who had visited all clinical departments of Steel Memorial Hirohata Hospital between May and August 2016, using the system...
February 14, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29437868/agalsidase-alfa-versus-agalsidase-beta-for-the-treatment-of-fabry-disease-an-international-cohort-study
#18
Maarten Arends, Marieke Biegstraaten, Christoph Wanner, Sandra Sirrs, Atul Mehta, Perry M Elliott, Daniel Oder, Oliver T Watkinson, Daniel G Bichet, Aneal Khan, Mark Iwanochko, Frédéric M Vaz, André B P van Kuilenburg, Michael L West, Derralynn A Hughes, Carla E M Hollak
BACKGROUND: Two recombinant enzymes (agalsidase alfa 0.2 mg/kg/every other week and agalsidase beta 1.0 mg/kg/every other week) have been registered for the treatment of Fabry disease (FD), at equal high costs. An independent international initiative compared clinical and biochemical outcomes of the two enzymes. METHODS: In this multicentre retrospective cohort study, clinical event rate, left ventricular mass index (LVMI), estimated glomerular filtration rate (eGFR), antibody formation and globotriaosylsphingosine (lysoGb3) levels were compared between patients with FD treated with agalsidase alfa and beta at their registered dose after correction for phenotype and sex...
May 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29435189/effect-of-metformin-on-kidney-function-in-patients-with-type-2-diabetes-mellitus-and-moderate-chronic-kidney-disease
#19
Wei-Hao Hsu, Pi-Jung Hsiao, Pi-Chen Lin, Szu-Chia Chen, Mei-Yueh Lee, Shyi-Jang Shin
Background: Impaired renal function can lead to the accumulation of metformin, and elevated concentrations of metformin have been associated with lactic acidosis. The aim of this study was to evaluate the effect of continuous metformin treatment in patients with type 2 diabetes mellitus (DM) and moderate chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) 30-0 ml/min/1.73 m2 ) on renal function. Methods: A total of the 616 patients were enrolled from the research database of Kaohsiung Medical University Hospital from January 1 to 2009 and December 31, 2013...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29409725/treatment-of-rheumatoid-arthritis-with-biologic-agents-lowers-the-risk-of-incident-chronic-kidney-disease
#20
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fatima Hassan, Fridtjof Thomas, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
Rheumatoid arthritis is associated with reduced kidney function, possibly due to chronic inflammation or the use of nephrotoxic therapies. However, little is known about the effects of using the newer novel non-nephrotoxic biologic agents on the risk of incident chronic kidney disease (CKD). To study this we used a cohort of 20,757 United States veterans diagnosed with rheumatoid arthritis with an estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73m2 or more, recruited between October 2004 and September 2006, and followed through 2013...
May 2018: Kidney International
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