Molly B Reilly, Tessa Tekieli, Cyril Cros, G Robert Aguilar, James Lao, Itai Antoine Toker, Berta Vidal, Eduardo Leyva-Díaz, Abhishek Bhattacharya, Steven J Cook, Jayson J Smith, Ismar Kovacevic, Burcu Gulez, Robert W Fernandez, Elisabeth F Bradford, Yasmin H Ramadan, Paschalis Kratsios, Zhirong Bao, Oliver Hobert
Homeobox genes are prominent regulators of neuronal identity, but the extent to which their function has been probed in animal nervous systems remains limited. In the nematode Caenorhabditis elegans, each individual neuron class is defined by the expression of unique combinations of homeobox genes, prompting the question of whether each neuron class indeed requires a homeobox gene for its proper identity specification. We present here progress in addressing this question by extending previous mutant analysis of homeobox gene family members and describing multiple examples of homeobox gene function in different parts of the C...
September 2022: PLoS Genetics