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https://www.readbyqxmd.com/read/28334108/fast-admixture-analysis-and-population-tree-estimation-for-snp-and-ngs-data
#1
Yu Jade Cheng, Thomas Mailund, Rasmus Nielsen
Structure methods are highly used population genetic methods for classifying individuals in a sample fractionally into discrete ancestry components. We introduce a new optimization algorithm for the classical STRUCTURE model in a maximum likelihood framework. Using analyses of real data we show that the new method finds solutions with higher likelihoods than the state-of-the-art method inthe same computational time. The optimization algorithm is also applicable to models based on genotype likelihoods, that can account for the uncertainty in genotype-calling associated with Next Generation Sequencing (NGS) data...
February 17, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28332886/inhaler-technique-mastery-and-maintenance-in-healthcare-professionals-trained-on-different-devices
#2
Sinthia Bosnic-Anticevich, Christina Callan, Henry Chrystyn, Federico Lavorini, Vasilis Nikolaou, Vicky Kritikos, P N Richard Dekhuijzen, Nicolas Roche, Leif Bjermer, Cynthia Rand, Nicholas Zwar, David B Price
OBJECTIVE: Healthcare professionals (HCPs) are required to assess and train patients in the correct use of inhalers but are often unable to demonstrate correct technique themselves. We sought to assess the level of training required for HCPs to master and maintain device mastery when using two different dry powder inhalers (DPIs). METHODS: We conducted a randomised, un-blinded, cross-over study in undergraduate HCPs who undertook a six-step training procedure (intuitive use, patient information leaflet, instructional video, individual tuition from expert, then two repeats of individual tuition) for the use of Turbuhaler® (an established device) and Spiromax® (a newer device, reportedly easier to use)...
March 23, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28332862/effective-practices-in-the-delivery-of-research-ethics-education-a-qualitative-review-of-instructional-methods
#3
E Michelle Todd, Brett S Torrence, Logan L Watts, Tyler J Mulhearn, Shane Connelly, Michael D Mumford
In order to delineate best practices for courses on research ethics, the goal of the present effort was to identify themes related to instructional methods reflected in effective research ethics and responsible conduct of research (RCR) courses. By utilizing a qualitative review, four themes relevant to instructional methods were identified in effective research ethics courses: active participation, case-based activities, a combination of individual and group approaches, and a small number of instructional methods...
March 1, 2017: Accountability in Research
https://www.readbyqxmd.com/read/28332861/treatment-of-nightmares-in-psychiatric-inpatients-with-imagery-rehearsal-therapy-an-open-trial-and-case-series
#4
Thomas E Ellis, Katrina A Rufino, Michael R Nadorff
OBJECTIVES: This study sought to assess the utility of Imagery Rehearsal Therapy (IRT) for nightmares in an inpatient psychiatric setting. Although IRT enjoys a substantial evidence base for efficacy in various populations, data with psychiatric inpatients are lacking. PARTICIPANTS: Participants were 20 adult psychiatric inpatients (11 male, 9 female; mean age=43.4), in an extended stay psychiatric inpatient facility. All participants were diagnosed with multiple, treatment resistant, comorbid conditions, including mood disorders, anxiety disorders, personality disorders, and substance-related disorders...
March 23, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28332707/effects-of-relational-uncertainty-in-heightening-national-identification-and-reactive-approach-motivation-of-japanese
#5
Yuto Terashima, Jiro Takai
This study investigated whether relational uncertainty poses uncertainty threat, which causes compensatory behaviours among Japanese. We hypothesised that Japanese, as collectivists, would perceive relational uncertainty to pose uncertainty threat. In two experiments, we manipulated relational uncertainty, and confirmed that participants exhibited compensatory reactions to reduce aversive feelings due to it. In Study 1, we conducted direct comparison between relational uncertainty, independent self-uncertainty and control conditions...
March 23, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28331356/individual-and-dyadic-coping-in-chronic-pain-patients
#6
Andrea Burri, Michèle Blank Gebre, Guy Bodenmann
The purpose of the current cross-sectional study was to test the associations between individual coping responses to pain, dyadic coping, and perceived social support, with a number of pain outcomes, including pain intensity, functional disability, and pain adjustment, in a sample of N = 43 patients suffering from chronic pain in Switzerland. In contrast to previous research, we were interested not only in specific pain coping but also in more general stress coping strategies and their potential influence on pain outcomes...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28329381/the-effects-of-an-afternoon-nap-on-episodic-memory-in-young-and-older-adults-napping-and-aging
#7
Michael K Scullin, Jacqueline Fairley, Michael J Decker, Donald L Bliwise
Study Objectives: In young adults, napping is hypothesized to benefit episodic memory retention (e.g., via consolidation). Whether this relationship is present in older adults has not been adequately tested, but is an important question because older adults display marked changes in sleep and memory. Design: Between-subjects design. Setting: Sleep laboratory at Emory University School of Medicine. Participants: 50 healthy young adults (18-29) and 45 community dwelling older adults (58-83)...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28325798/management-of-inpatient-hyperglycemia-and-diabetes-in-older-adults
#8
Guillermo E Umpierrez, Francisco J Pasquel
Adults aged 65 years and older are the fastest growing segment of the U.S. population, and their number is expected to double to 89 million between 2010 and 2050. The prevalence of diabetes in hospitalized adults aged 65-75 years and over 80 years of age has been estimated to be 20% and 40%, respectively. Similar to general populations, the presence of hyperglycemia and diabetes in elderly patients is associated with increased risk of hospital complications, longer length of stay, and increased mortality compared with subjects with normoglycemia...
April 2017: Diabetes Care
https://www.readbyqxmd.com/read/28324971/a-small-portable-battery-powered-brain-computer-interface-system-for-motor-rehabilitation
#9
Colin M McCrimmon, Ming Wang, Lucas Silva Lopes, Po T Wang, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do
Motor rehabilitation using brain-computer interface (BCI) systems may facilitate functional recovery in individuals after stroke or spinal cord injury. Nevertheless, these systems are typically ill-suited for widespread adoption due to their size, cost, and complexity. In this paper, a small, portable, and extremely cost-efficient (<;$200) BCI system has been developed using a custom electroencephalographic (EEG) amplifier array, and a commercial microcontroller and touchscreen. The system's performance was tested using a movement-related BCI task in 3 able-bodied subjects with minimal previous BCI experience...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322356/efficacy-of-motivational-interviewing-in-conjunction-with-caries-risk-assessment-micra-programmes-in-improving-the-dental-health-status-of-preschool-children-a-randomised-controlled-trial
#10
Saruta Saengtipbovorn
PURPOSE: To assess the efficacy of motivational interviewing in conjuction with a caries risk assessment (MICRA) programme to improve the dental health status of preschool children. MATERIALS AND METHODS: A randomised controlled trial was conducted among 214 parents or caregivers and their children at Health Centre 54, Bangkok, Thailand, from September 2015 to February 2016. The participants were randomised to the intervention and the control groups (107 participants per group)...
March 20, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28322240/international-spinal-cord-injury-endocrine-and-metabolic-extended-data-set
#11
W A Bauman, J M Wecht, F Biering-Sørensen
OBJECTIVE: The objective of this study was to develop the International Spinal Cord Injury (SCI) Endocrine and Metabolic Extended Data Set (ISCIEMEDS) within the framework of the International SCI Data Sets that would facilitate consistent collection and reporting of endocrine and metabolic findings in the SCI population. SETTING: This study was conducted in an international setting. METHODS: The ISCIEMEDS was developed by a working group...
March 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28319204/responses-to-others-pain-in-adults-with-autistic-traits-the-influence-of-gender-and-stimuli-modality
#12
Jing Meng, Zuoshan Li, Lin Shen
Individuals with autism-spectrum disorder (ASD) exhibit impairments in response to others' pain. Evidence suggests that features of autism are not restricted to individuals with ASD, and that autistic traits vary throughout the general population. To investigate the association between autistic traits and the responses to others' pain in typically developing adults, we employed the Autism-Spectrum Quotient (AQ) to quantify autistic traits in a group of 1670 healthy adults and explored whether 60 participants (30 males and 30 females) with 10% highest AQ scores (High-AQ) would exhibit difficulties in the responses to others' pain relative to 60 participants (30 males and 30 females) with 10% lowest AQ scores (Low-AQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28317095/evaluating-helicopter-emergency-medical-missions-a-reliability-study-of-the-hems-benefit-and-naca-scores
#13
L Raatiniemi, J Liisanantti, M Tommila, S Moilanen, P Ohtonen, M Martikainen, V Voipio, J Reitala, T Iirola
BACKGROUND: The benefits of the Helicopter Emergency Medical Service (HEMS) and dispatch accuracy are continuously debated, and a widely accepted score to measure the benefits of the mission is lacking. The HEMS Benefit Score (HBS) has been used in Finnish helicopter emergency medical services, but studies are lacking. The National Advisory Committee for Aeronautics (NACA) score is widely used to measure the severity of illness or injury in the pre-hospital setting, but it has many critics due to its subjectivity...
March 19, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28315594/goal-neglect-fluid-intelligence-and-processing-speed-manipulating-instruction-load-and-inter-stimulus-interval
#14
Matthew H Iveson, Sergio Della Sala, Mike Anderson, Sarah E MacPherson
Goal maintenance is the process where task rules and instructions are kept active to exert their control on behavior. When this process fails, an individual may ignore a rule while performing the task, despite being able to describe it after task completion. Previous research has suggested that the goal maintenance system is limited by the number of concurrent rules which can be maintained during a task, and that this limit is dependent on an individual's level of fluid intelligence. However, the speed at which an individual can process information may also limit their ability to use task rules when the task demands them...
March 15, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28315522/human-cardiac-fibroblasts-adaptive-responses-to-controlled-combined-mechanical-strain-and-oxygen-changes-in-vitro
#15
Giovanni Stefano Ugolini, Andrea Pavesi, Marco Rasponi, Gianfranco Beniamino Fiore, Roger Kamm, Monica Soncini
Upon cardiac pathological conditions such as ischemia, microenvironmental changes instruct a series of cellular responses that trigger cardiac fibroblasts-mediated tissue adaptation and inflammation. A comprehensive model of how early environmental changes may induce cardiac fibroblasts (CF) pathological responses is far from being elucidated, partly due to the lack of approaches involving complex and simultaneous environmental stimulation. Here, we provide a first analysis of human primary CF behavior by means of a multi-stimulus microdevice for combined application of cyclic mechanical strain and controlled oxygen tension...
March 18, 2017: ELife
https://www.readbyqxmd.com/read/28299561/america-competes-at-5%C3%A2-years-an-analysis-of-research-intensive-universities-rcr-training-plans
#16
Trisha Phillips, Franchesca Nestor, Gillian Beach, Elizabeth Heitman
This project evaluates the impact of the National Science Foundation's (NSF) policy to promote education in the responsible conduct of research (RCR). To determine whether this policy resulted in meaningful RCR educational experiences, our study examined the instructional plans developed by individual universities in response to the mandate. Using a sample of 108 U.S. institutions classified as Carnegie "very high research activity", we analyzed all publicly available NSF RCR training plans in light of the consensus best practices in RCR education that were known at the time the policy was implemented...
March 15, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28297084/changing-tastes-learning-hunger-and-fullness-after-gastric-bypass-surgery
#17
Line Hillersdal, Bodil J Christensen, Lotte Holm
Gastric bypass surgery is a specific medical technology that alters the body in ways that force patients to fundamentally change their eating habits. When patients enrol for surgery, they enter a learning process, encountering new and at times contested ways of sensing their bodies, tasting, and experiencing hunger and fullness. In this paper, we explore how patients begin to eat again after gastric bypass surgery. The empirical data used here are drawn from a Danish fieldwork study of individuals undergoing obesity surgery...
March 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28295409/working-memory-capacity-and-task-goals-modulate-error-related-erps
#18
James R Coleman, Jason M Watson, David L Strayer
The present study investigated individual differences in information processing following errant behavior. Participants were initially classified as high or as low working memory capacity using the Operation Span Task. In a subsequent session, they then performed a high congruency version of the flanker task under both speed and accuracy stress. We recorded ERPs and behavioral measures of accuracy and response time in the flanker task with a primary focus on processing following an error. The error-related negativity was larger for the high working memory capacity group than for the low working memory capacity group...
March 15, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28292684/meta-analytical-assessment-of-the-effects-of-protocol-variations-on-cortisol-responses-to-the-trier-social-stress-test
#19
REVIEW
William K Goodman, Johanna Janson, Jutta M Wolf
BACKGROUND: The Trier Social Stress Test (TSST) is one of the most widely used laboratory stress tests. Exposure to this psychosocial stressor has been shown to stimulate an acute cortisol stress response in the majority of healthy individuals, while deviations from the typical pattern, i.e., cortisol reactivity dysfunctions have been linked to an ever-increasing number of negative health outcomes. However, significant variability between labs exists in strength of observed cortisol responses in healthy individuals...
March 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28292508/pharmacy-based-statewide-naloxone-distribution-a-novel-top-down-bottom-up-approach
#20
Kate J Morton, Brianna Harrand, Carly Cloud Floyd, Craig Schaefer, Julie Acosta, Bridget Claire Logan, Karen Clark
OBJECTIVE: To highlight New Mexico's multifaceted approach to widespread pharmacy naloxone distribution and to share the interventions as a tool for improving pharmacy-based naloxone practices in other states. SETTING: New Mexico had the second highest drug overdose death rate in 2014 of which 53% were related to prescription opioids. Opioid overdose death is preventable through the use of naloxone, a safe and effective medication that reverses the effects of prescription opioids and heroin...
March 2017: Journal of the American Pharmacists Association: JAPhA
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