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https://www.readbyqxmd.com/read/28646851/development-of-an-education-campaign-to-reduce-delays-in-pre-hospital-response-to-stroke
#1
Caterina Caminiti, Peter Schulz, Barbara Marcomini, Elisa Iezzi, Silvia Riva, Umberto Scoditti, Andrea Zini, Giovanni Malferrari, Maria Luisa Zedde, Donata Guidetti, Enrico Montanari, Mario Baratti, Licia Denti
BACKGROUND: Systematic reviews call for well-designed trials with clearly described intervention components to support the effectiveness of educational campaigns to reduce patient delay in stroke presentation. We herein describe the systematic development process of a campaign aimed to increase stroke awareness and preparedness. METHODS: Campaign development followed Intervention Mapping (IM), a theory- and evidence-based tool, and was articulated in two phases: needs assessment and intervention development...
June 24, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28645893/introductory-biology-students-use-of-enhanced-answer-keys-and-reflection-questions-to-engage-in-metacognition-and-enhance-understanding
#2
Jaime L Sabel, Joseph T Dauer, Cory T Forbes
Providing feedback to students as they learn to integrate individual concepts into complex systems is an important way to help them to develop robust understanding, but it is challenging in large, undergraduate classes for instructors to provide feedback that is frequent and directed enough to help individual students. Various scaffolds can be used to help students engage in self-regulated learning and generate internal feedback to improve their learning. This study examined the use of enhanced answer keys with added reflection questions and instruction as scaffolds for engaging undergraduate students in self-regulated learning within an introductory biology course...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28645367/base-excision-repair-variants-in-cancer
#3
Carolyn G Marsden, Julie A Dragon, Susan S Wallace, Joann B Sweasy
Base excision repair (BER) is a key genome maintenance pathway that removes endogenously damaged DNA bases that arise in cells at very high levels on a daily basis. Failure to remove these damaged DNA bases leads to increased levels of mutagenesis and chromosomal instability, which have the potential to drive carcinogenesis. Next-generation sequencing of the germline and tumor genomes of thousands of individuals has uncovered many rare mutations in BER genes. Given that BER is critical for genome maintenance, it is important to determine whether BER genomic variants have functional phenotypes...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28643008/correction-of-rhytides-peau-d-orange-and-thin-dermis-of-the-face-by-neocollagenesis-using-novel-collagen-stimulating-slurry-protocol
#4
Steven Dominguez, Marek Dobke
We reviewed 200 patient records from 2009 to 2015 of individuals who presented at the authors offices for facial wrinkle reduction and who on physical examination had rhytides, peau d'orange, or thin dermis and underwent novel adipose slurry injections. The patients were evaluated at week 2, 1, 3 and 6 months revealing an 80, 60 and 40% improvement in rhytides and dermis density, respectively. We present the protocol and description of a reasonable alternative or adjunct to manufactured fillers that is comprised of autologous adipose, stem cells, and growth factor slurry...
June 22, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28642213/development-of-a-web-based-intervention-for-addressing-distress-in-caregivers-of-patients-receiving-stem-cell-transplants-formative-evaluation-with-stakeholder-interviews-and-focus-groups
#5
Nicole Amoyal Pensak, Tanisha Joshi, Teresa Simoneau, Kristin Kilbourn, Alaina Carr, Jean Kutner, Mark L Laudenslager
BACKGROUND: Caregivers of cancer patients experience significant burden and distress including depression and anxiety. We previously demonstrated the efficacy of an eight session, in-person, one-on-one stress management intervention to reduce distress in caregivers of patients receiving allogeneic hematopoietic stem cell transplants (allo-HSCT). OBJECTIVE: The objective of this study was to adapt and enhance the in-person caregiver stress management intervention to a mobilized website (eg, tablet, smartphone, or computer-based) for self-delivery in order to enhance dissemination to caregiver populations most in need...
June 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28639106/time-to-selected-quit-date-and-subsequent-rates-of-sustained-smoking-abstinence
#6
George L Anesi, Scott D Halpern, Michael O Harhay, Kevin G Volpp, Kathryn Saulsgiver
In efforts to combat tobacco dependence, most smoking cessation programs offer individuals who smoke the choice of a target quit date. However, it is uncertain whether the time to the selected quit date is associated with participants' chances of achieving sustained abstinence. In a pre-specified secondary analysis of a randomized clinical trial of four financial-incentive programs or usual care to encourage smoking cessation (Halpern et al. in N Engl J Med 372(22):2108-2117, doi: 10.1056/NEJMoa1414293 , 2015), study participants were instructed to select a quit date between 0 and 90 days from enrollment...
June 21, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28637818/the-cerebellum-does-more-than-sensory-prediction-error-based-learning-in-sensorimotor-adaptation-tasks
#7
Peter A Butcher, Richard B Ivry, Sheng-Han Kuo, David Rydz, John W Krakauer, Jordan A Taylor
Individuals with damage to the cerebellum perform poorly in sensorimotor adaptation paradigms. This deficit has been attributed to impairment in sensory-prediction-error-based updating of an internal forward model, a form of implicit learning. These individuals can, however, successfully counter a perturbation when instructed with an explicit aiming strategy. This successful use of an instructed aiming strategy presents a paradox: In adaptation tasks, why don't individuals with cerebellar damage come up with an aiming solution on their own to compensate for their implicit learning deficit? To explore this question, we employed a variant of a visuomotor rotation task in which, prior to executing a movement on each trial, the participants verbally reported their intended aiming location...
June 21, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28633044/written-accounts-of-living-with-psychogenic-nonepileptic-seizures-a-thematic-analysis
#8
Gregg H Rawlings, Ian Brown, Brendan Stone, Markus Reuber
PURPOSE: Qualitative studies examining lived experiences of psychogenic nonepileptic seizures (PNES) have predominantly relied on datasets collected using clinical or research interviews. This study pursued a different approach by investigating individuals' written accounts of their condition. METHODS: Participants (n=19) were recruited from membership-led organisations for individuals living with seizures and from a United Kingdom hospital. Participants were instructed to produce four pieces of writing: 1) about their thoughts and feelings about their condition; 2) a letter to their condition; 3) a letter to their younger self; and 4) about a personal value...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28632444/the-structural-consequences-of-big-data-driven-education
#9
Elana Zeide
Educators and commenters who evaluate big data-driven learning environments focus on specific questions: whether automated education platforms improve learning outcomes, invade student privacy, and promote equality. This article puts aside separate unresolved-and perhaps unresolvable-issues regarding the concrete effects of specific technologies. It instead examines how big data-driven tools alter the structure of schools' pedagogical decision-making, and, in doing so, change fundamental aspects of America's education enterprise...
June 2017: Big Data
https://www.readbyqxmd.com/read/28632104/bimanual-lifting-do-fingertip-forces-work-independently-or-interactively
#10
Pan Dimitriou, Gavin Buckingham
Bimanual coordination is a commonplace activity, but the consequences of using both hands simultaneously are not well understood. The authors examined fingertip forces across 4 experiments in which participants undertook a range of bimanual tasks. They first measured fingertip forces during simultaneous lifts of 2 identical objects, noting that individuals held the objects with more force bimanually than unimanually. They then varied the mass of the objects held by each hand, noting that when both hands lifted together performance was equivalent to unimanual lifts...
March 2, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28632008/a-cloud-with-a-silver-lining-helping-students-learn-about-professionalism
#11
Rhea J Cohn, Margaret M Plack
PROBLEM: Educators face many challenges in teaching professionalism. Despite attempts to define professionalism, it remains abstract for students and often not fully appreciated until they are in clinic. Without a way to make it personally relevant, students will likely be less motivated to learn. INTERVENTION: We used student-generated word clouds to facilitate reflection and discussions, thereby helping students make their perceptions of professionalism more explicit...
February 16, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28630145/activity-dependent-trafficking-of-lysosomes-in-dendrites-and-dendritic-spines
#12
Marisa S Goo, Laura Sancho, Natalia Slepak, Daniela Boassa, Thomas J Deerinck, Mark H Ellisman, Brenda L Bloodgood, Gentry N Patrick
In neurons, lysosomes, which degrade membrane and cytoplasmic components, are thought to primarily reside in somatic and axonal compartments, but there is little understanding of their distribution and function in dendrites. Here, we used conventional and two-photon imaging and electron microscopy to show that lysosomes traffic bidirectionally in dendrites and are present in dendritic spines. We find that lysosome inhibition alters their mobility and also decreases dendritic spine number. Furthermore, perturbing microtubule and actin cytoskeletal dynamics has an inverse relationship on the distribution and motility of lysosomes in dendrites...
June 19, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28627915/long-term-classroom-functioning-and-its-association-with-neuropsychological-and-academic-performance-following-traumatic-brain-injury-during-early-childhood
#13
Amery Treble-Barna, Hanna Schultz, Nori Minich, H Gerry Taylor, Keith Owen Yeates, Terry Stancin, Shari L Wade
OBJECTIVE: The present study utilized ecobehavioral assessment to examine classroom functioning several years following early childhood traumatic brain injury (TBI) or orthopedic injury (OI) and its association with injury factors, neuropsychological abilities, and academic performance. METHOD: Participants included 39 children with moderate to severe TBI and 51 children with OI sustained between ages 3 and 7 years. At 7.2 (± 1.3) years post injury, ecobehavioral assessment was used to examine classroom functioning...
July 2017: Neuropsychology
https://www.readbyqxmd.com/read/28625793/comparison-of-sputum-collection-methods-for-tuberculosis-diagnosis-a-systematic-review-and-pairwise-and-network-meta-analysis
#14
Sumona Datta, Lena Shah, Robert H Gilman, Carlton A Evans
BACKGROUND: The performance of laboratory tests to diagnose pulmonary tuberculosis is dependent on the quality of the sputum sample tested. The relative merits of sputum collection methods to improve tuberculosis diagnosis are poorly characterised. We therefore aimed to investigate the effects of sputum collection methods on tuberculosis diagnosis. METHODS: We did a systematic review and meta-analysis to investigate whether non-invasive sputum collection methods in people aged at least 12 years improve the diagnostic performance of laboratory testing for pulmonary tuberculosis...
June 15, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28621025/dorsal-root-ganglion-stimulation-as-a-salvage-treatment-for-complex-regional-pain-syndrome-refractory-to-dorsal-column-spinal-cord-stimulation-a-case-series
#15
Ajax Yang, Corey W Hunter
OBJECTIVE: The efficacy of traditional spinal cord stimulation (t-SCS) tends to decay over time in patients with complex regional pain syndrome (CRPS). While it has been shown that dorsal root ganglion (DRG) stimulation is extremely effective in t-SCS-naïve patients with CRPS, its efficacy in patients who had previously failed t-SCS is unknown. Given that DRG-SCS and t-SCS target different spinal pathways, a failure with t-SCS should not automatically preclude a patient from attempting DRG-SCS...
June 16, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28620831/cephalopod-biology-and-care-a-cost-fa1301-cephsinaction-training-school-anaesthesia-and-scientific-procedures
#16
Vanessa M Lopes, Eduardo Sampaio, Katina Roumbedakis, Nobuaki K Tanaka, Lucía Carulla, Guillermo Gambús, Theodosia Woo, Catarina P P Martins, Virginie Penicaud, Colette Gibbings, Jessica Eberle, Perla Tedesco, Isabel Fernández, Tania Rodríguez-González, Pamela Imperadore, Giovanna Ponte, Graziano Fiorito
Cephalopods are the sole invertebrates included in the list of regulated species following the Directive 2010/63/EU. According to the Directive, achieving competence through adequate training is a requisite for people having a role in the different functions (article 23) as such carrying out procedures on animals, designing procedures and projects, taking care of animals, killing animals. Cephalopod Biology and Care Training Program is specifically designed to comply with the requirements of the "working document on the development of a common education and training framework to fulfil the requirements under the Directive 2010/63/EU"...
September 2017: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/28618918/does-guiding-toward-task-relevant-information-help-improve-graph-processing-and-graph-comprehension-of-individuals-with-low-or-high-numeracy-an-eye-tracker-experiment
#17
Carmen Keller, Alex Junghans
BACKGROUND: Individuals with low numeracy have difficulties with understanding complex graphs. Combining the information-processing approach to numeracy with graph comprehension and information-reduction theories, we examined whether high numerates' better comprehension might be explained by their closer attention to task-relevant graphical elements, from which they would expect numerical information to understand the graph. Furthermore, we investigated whether participants could be trained in improving their attention to task-relevant information and graph comprehension...
June 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28616126/autistic-traits-affect-interpersonal-motor-coordination-by-modulating-strategic-use-of-role-based-behavior
#18
Arianna Curioni, Ilaria Minio-Paluello, Lucia Maria Sacheli, Matteo Candidi, Salvatore Maria Aglioti
BACKGROUND: Despite the fact that deficits in social communication and interaction are at the core of Autism Spectrum Conditions (ASC), no study has yet tested individuals on a continuum from neurotypical development to autism in an on-line, cooperative, joint action task. In our study, we aimed to assess whether the degree of autistic traits affects participants' ability to modulate their motor behavior while interacting in a Joint Grasping task and according to their given role. METHODS: Sixteen pairs of adult participants played a cooperative social interactive game in which they had to synchronize their reach-to-grasp movements...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28611703/-you-should-have-seen-the-look-on-your-face%C3%A2-self-awareness-of-facial-expressions
#19
Fangbing Qu, Wen-Jing Yan, Yu-Hsin Chen, Kaiyun Li, Hui Zhang, Xiaolan Fu
The awareness of facial expressions allows one to better understand, predict, and regulate his/her states to adapt to different social situations. The present research investigated individuals' awareness of their own facial expressions and the influence of the duration and intensity of expressions in two self-reference modalities, a real-time condition and a video-review condition. The participants were instructed to respond as soon as they became aware of any facial movements. The results revealed that awareness rates were 57...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28610648/personality-traits-and-thinking-dispositions-individual-differences-call-for-smart-messaging
#20
Lorilee A Medders, Sarah K Baisley
This paper reveals potentially innate psychological differences to explain differing responses to the same information that cannot be explained by personal circumstances, such as age, financial situation and physical constraints. The study examines three well-known cognitive, psychological constructs as measures of these innate differences: cognitive reflection, need for cognitive closure and psychological function preferences. The data reveal who innately: (1) makes the best decisions without full information; (2) is the most/least receptive to simple, instructive messages; and (3) is the most credible information intermediary...
June 1, 2017: Journal of Business Continuity & Emergency Planning
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