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https://www.readbyqxmd.com/read/29334576/cheek-volumization-and-nasolabial-folds
#1
Donald S Mowlds, Val Lambros
The impression that cheek filling results in longitudinal shortening ("lift") of the skin and elevation of the nasolabial crease(NLC) or nasolabial fold (NLF) has become common within the facial injection community, but remains unsubstantiated. In this study, seventy-seven patients were evaluated pre and post-injection injection of the cheeks with an Hyaluronic Acid filler using a 3-dimensional camera system. A constant pattern of skin expansion away from the center of the injection and perpendicular to the surface of the skin was observed...
January 10, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29334575/measurement-of-warping-angle-in-human-rib-graft-experimental-study
#2
Safvet Ors
To determine the warping angle of the costal cartilage in vivo. A nasal framework reconstruction with a rib graft was performed in a total of 130 patients. After the cartilage specimens were prepared, the remaining grafts were used for the experimental study. The angle of warping in all grafts was measured at 0, 30, and 60 minutes, after 24 hours and after one week. In this study, 8 subgroups of graft thicknesses from central and peripheral groups, which were determined according to the perichondral distance of the grafts, were evaluated, and the warping angles of a total of 48 osteochondral and chondral grafts were individually measured...
January 10, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29334121/the-multipotency-to-commitment-transition-mct-in-c-elegans-implications-for-reprogramming-from-cells-to-organs
#3
REVIEW
Erik A Spickard, Pradeep M Joshi, Joel H Rothman
In animal embryos, cells transition from a multipotential state, with the capacity to adopt multiple fates, into an irreversible, committed state of differentiation. This multipotency-to-commitment transition (MCT) is evident from experiments in which cell fate is reprogrammed by transcription factors for cell-type-specific differentiation, as has been observed extensively in C. elegans. Although factors that direct differentiation into each of the three germ layer types cannot generally reprogram cells after the MCT in this animal, transcription factors for endoderm development are able to do so in multiple differentiated cell types...
January 15, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29333820/osteomyelitis-in-burn-children-ten-years-of-experience
#4
María T Rosanova, Carla Voto, Susana Carnovale, Nidia Tramonti, Jimena Lema, José L Pinheiro, Adela Isasmendi, Verónica Alvarez, Rosa M Villasboas, Santiago Laborde, Hugo Basílico
INTRODUCTION: Osteomyelitis is uncommon among burn patients. OBJECTIVE: To describe the clinical, microbiological, and evolutionary characteristics of burn children with osteomyelitis hospitalized in a tertiary care facility. METHODS: Retrospective and descriptive study conducted between January 2007 and January 2017. RESULTS: Out of 600 burn children, 12 developed osteomyelitis (incidence: 2%). Eleven patients had a burn caused by direct fire...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333728/population-correlations-do-not-support-the-existence-of-set-points-for-blood-levels-of-calcium-or-glucose-a-new-model-for-homeostasis
#5
Stephen P Fitzgerald, Nigel G Bean
The prevailing teaching regarding homeostasis, and in particular endocrine homeostasis, includes the fundamental concept of a "set point," which represents a target or optimum level defended by physiological control mechanisms. Analogies for the description and teaching of this concept have included thermostats and cruise controls. We previously demonstrated that such a set-point model of regulation implies that in population data of parameter set point/controlling hormone levels, correlations between the parameter and its controlling hormone must be in the direction of the response of the parameter to its controlling hormone, and that in thyroid homeostasis this relationship is not observed...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29333702/maml1-and-twist1-co-overexpression-promote-invasion-of-head-and-neck-squamous-cell-carcinoma
#6
Sima Ardalan Khales, Ehsan Ebrahimi, Eisa Jahanzad, Sahar Ardalan Khales, Mohammad Mahdi Forghanifard
AIMS: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with considerable morbidity and mortality. Invasion and metastasis of HNSCC is a complex process involving multiple molecules and signaling pathways. Twist Family BHLH Transcription Factor 1 (TWIST1) and Mastermind-like 1 (MAML1) are essential in induction of epithelial-mesenchymal transition through direct regulation of implicated molecules in cellular adhesion, migration and invasion. Our aim in this study was to assess the clinical significance of MAML1 and TWIST1 expression in HNSCC, and elucidate the probable correlation between these genes to exhibit their possible associations with progression and metastasis of the disease...
January 15, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29333637/increased-free-zn2-correlates-induction-of-sarco-endo-plasmic-reticulum-stress-via-altered-expression-levels-of-zn2-transporters-in-heart-failure
#7
Yusuf Olgar, Aysegul Durak, Erkan Tuncay, Ceylan Verda Bitirim, Evren Ozcinar, Mustafa Bahadir Inan, Zeynep Tokcaer-Keskin, Kamil Can Akcali, Ahmet Ruchan Akar, Belma Turan
Zn2+ -homoeostasis including free Zn2+ ([Zn2+ ]i ) is regulated through Zn2+ -transporters and their comprehensive understanding may be important due to their contributions to cardiac dysfunction. Herein, we aimed to examine a possible role of Zn2+ -transporters in the development of heart failure (HF) via induction of ER stress. We first showed localizations of ZIP8, ZIP14 and ZnT8 to both sarcolemma and S(E)R in ventricular cardiomyocytes (H9c2 cells) using confocal together with calculated Pearson's coefficients...
January 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29333571/diurnal-variations-in-personal-care-products-in-seawater-and-mussels-at-three-mediterranean-coastal-sites
#8
Marina Picot-Groz, Hélène Fenet, Maria Jesus Martinez Bueno, David Rosain, Elena Gomez
The presence of personal care products (PCPs) in the marine environment is of major concern. PCPs, UV filters, and musks can enter the marine environment indirectly through wastewater or directly via recreational activities. We conducted this study to document patterns in the occurrence of seven PCPs at three coastal sites impacted by recreational activities during 1 day. The study focused on diurnal variations in these seven PCPs in seawater and indigenous mussels. In seawater, UV filters showed diurnal variations that mirrored variations in recreational activities at the sites...
January 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29333554/in-cell-nmr-from-metabolites-to-macromolecules
#9
REVIEW
G Lippens, E Cahoreau, P Millard, C Charlier, J Lopez, X Hanoulle, J C Portais
In-cell NMR of macromolecules has gained momentum over the last ten years as an approach that might bridge the branches of cell biology and structural biology. In this review, we put it in the context of earlier efforts that aimed to characterize by NMR the cellular environment of live cells and their intracellular metabolites. Although technical aspects distinguish these earlier in vivo NMR studies and the more recent in cell NMR efforts to characterize macromolecules in a cellular environment, we believe that both share major concerns ranging from sensitivity and line broadening to cell viability...
January 15, 2018: Analyst
https://www.readbyqxmd.com/read/29333203/biomimetic-microfluidic-platform-for-the-quantification-of-transient-endothelial-monolayer-permeability-and-therapeutic-transport-under-mimicked-cancerous-conditions
#10
Christopher George Uhl, Vladimir R Muzykantov, Yaling Liu
Therapeutic delivery from microvasculature to cancerous sites is influenced by many factors including endothelial permeability, vascular flow rates/pressures, cancer secretion of cytokines and permeabilizing agents, and characteristics of the chosen therapeutics. This work uses bi-layer microfluidics capable of studying dye and therapeutic transport from a simulated vessel to a cancerous region while allowing for direct visualization and quantification of endothelial permeability. 2.5 to 13 times greater dye transport was observed when utilizing small dye sizes (FITC) when compared to larger molecules (FITC-Dextran 4 kDa and FITC-Dextran 70 kDa), respectively...
January 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29333198/response-of-pacific-sector-antarctic-ice-shelves-to-the-el-ni%C3%A3-o-southern-oscillation
#11
F S Paolo, L Padman, H A Fricker, S Adusumilli, S Howard, M R Siegfried
Satellite observations over the past two decades have revealed increasing loss of grounded ice in West Antarctica, associated with floating ice shelves that have been thinning. Thinning reduces an ice-shelf's ability to restrain grounded-ice discharge, yet our understanding of the climate processes that drive mass changes is limited. Here, we use ice-shelf height data from four satellite altimeter missions (1994-2017) to show a direct link between ice-shelf-height variability in the Antarctic Pacific sector and changes in regional atmospheric circulation driven by the El Niño-Southern Oscillation...
January 2018: Nature Geoscience
https://www.readbyqxmd.com/read/29332951/soil-seal-development-under-simulated-rainfall-structural-physical-and-hydrological-dynamics
#12
Elena Armenise, Robert W Simmons, Sujung Ahn, Amin Garbout, Stefan H Doerr, Sacha J Mooney, Craig J Sturrock, Karl Ritz
This study delivers new insights into rainfall-induced seal formation through a novel approach in the use of X-ray Computed Tomography (CT). Up to now seal and crust thickness have been directly quantified mainly through visual examination of sealed/crusted surfaces, and there has been no quantitative method to estimate this important property. X-ray CT images were quantitatively analysed to derive formal measures of seal and crust thickness. A factorial experiment was established in the laboratory using open-topped microcosms packed with soil...
January 2018: Journal of Hydrology
https://www.readbyqxmd.com/read/29332755/investigating-the-anticipatory-postural-adjustment-phase-of-gait-initiation-in-different-directions-in-chronic-ankle-instability-patients
#13
Zahra Ebrahimabadi, Sedigheh Sadat Naimi, Abbas Rahimi, Heydar Sadeghi, Seyed Majid Hosseini, Alireza Akbarzadeh Baghban, Syed Asadullah Arslan
OBJECTIVE: The main objective of the present study was to analyze how supra spinal motor control mechanisms are altered in different directions during anticipatory postural phase of gait initiation in chronic ankle instability patients. It seems that supra spinal pathways modulate anticipatory postural adjustment phase of gait initiation. Yet, there is a dearth of research on the effect of chronic ankle instability on the anticipatory postural adjustment phase of gait initiation in different directions...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332749/long-term-effect-of-direction-movement-control-training-on-female-patients-with-chronic-neck-pain
#14
Zohreh Khosrokiani, Amir Letafatkar, Yahya Sokhanguei
BACKGROUND: Treatment of movement faults in the neck is known as an important factor in treatment of chronic neck pain. Along with the identification of site and direction of the faults, direction-movement control intervention retrains the control of the movement faults. PURPOSE: This study was designed to investigate long-term effects of a direction-movement control training on pain, disability, head repositioning accuracy, function, cervical flexor endurance, and range of motion in female patients with chronic nonspecific neck pain...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332655/research-on-tuberculosis-in-tribal-areas-in-india-a-systematic-review
#15
REVIEW
V G Rao, M Muniyandi, J Bhat, R Yadav, R Sharma
BACKGROUND: Tuberculosis (TB) remains a major public health problem in resource-poor countries including India. Scientific knowledge is used to guide policy and practice. There is however, a limited, systematically collected data required for guiding the scale-up of interventions particularly amongst vulnerable populations including tribal groups in the country. In view of this, a systematic review of the TB research studies carried out in tribal areas of different parts of the country was undertaken...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29332653/efficacy-of-alternate-day-directly-observed-treatment-short-course-dots-in-skeletal-tuberculosis-a-retrospective-study
#16
Rajat Chopra, Rama Bhatt, S K Biswas, R Bhalla
OBJECTIVE: To assess the efficacy of alternate day (thrice a week) Directly Observed Treatment Short-course (DOTS) regimen spanning six to nine months in providing sustained cure for skeletal tuberculosis (TB) under programmatic conditions. DESIGN: Retrospective cohort study. SETTING: An urban district tuberculosis centre in India under the Revised National Tuberculosis Programme. PARTICIPANTS: A cohort of 218 patients treated with alternate day DOTS regimen for skeletal TB between 2007 and 2012...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29332470/a-school-based-neuromuscular-training-program-and-sport-related-injury-incidence-a-prospective-randomized-controlled-clinical-trial
#17
Kim D Barber Foss, Staci Thomas, Jane C Khoury, Gregory D Myer, Timothy E Hewett
CONTEXT:   An estimated 40 million school-aged children (age range = 5-18 years) participate annually in sports in the United States, generating approximately 4 million sport-related injuries and requiring 2.6 million emergency department visits at a cost of nearly $2 billion. OBJECTIVE:   To determine the effects of a school-based neuromuscular training (NMT) program on sport-related injury incidence across 3 sports at the high school and middle school levels, focusing particularly on knee and ankle injuries...
January 13, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29332326/carcinogenic-potential-of-antitumor-therapies-is-the-risk-predictable
#18
Ivanka Nenova, Janet Grudeva-Popova
The growing number of successfully cured cancer patients has created a new field in oncogenesis. The life expectancy of such patients has increased, however this favorable event may create enough time for epigenetic events to occur which can cause a new carcinognic event, i.e. a secondary malignancy. The terms in use are second primary malignancies as well as therapy-related neoplasms in case the treatment of the first neoplasm is a direct cause. Second primary malignancies can be hematological neoplasms or solid tumors, with solid tumors having higher frequency...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332164/skewing-of-the-genetic-architecture-at-the-zmym3-human-specific-5-utr-short-tandem-repeat-in-schizophrenia
#19
F Alizadeh, A Bozorgmehr, J Tavakkoly-Bazzaz, M Ohadi
Differential expansion of a number of human short tandem repeats (STRs) at the critical core promoter and 5' untranslated region (UTR) support the hypothesis that at least some of these STRs may provide a selective advantage in human evolution. Following a genome-wide screen of all human protein-coding gene 5' UTRs based on the Ensembl database ( http://www.ensembl.org ), we previously reported that the longest STR in this interval is a (GA)32, which belongs to the X-linked zinc finger MYM-type containing 3 (ZMYM3) gene...
January 13, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29332037/increased-vulnerability-of-the-hippocampus-in-transgenic-mice-overexpressing-app-and-triple-repeat-tau
#20
Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissman
 Alzheimer's disease (AD) is the most common tauopathy, characterized by progressive accumulation of amyloid-β (Aβ) and hyperphosphorylated tau. While pathology associated with the 4-repeat (4R) tau isoform is more abundant in corticobasal degeneration and progressive supranuclear palsy, both 3R and 4R tau isoforms accumulate in AD. Many studies have investigated interactions between Aβ and 4R tau in double transgenic mice, but few, if any, have examined the effects of Aβ with 3R tau. To examine this relationship, we crossed our APP751 mutant line with our recently characterized 3R tau mutant model to create a bigenic line (hAPP-3RTau) to model AD neuropathology...
2018: Journal of Alzheimer's Disease: JAD
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