Ana S André, Joana N R Dias, Sandra I Aguiar, Ana Leonardo, Sara Nogueira, Joana D Amaral, Célia Fernandes, Lurdes Gano, João D G Correia, Marco Cavaco, Vera Neves, Jorge Correia, Miguel Castanho, Cecília M P Rodrigues, Maria Manuela Gaspar, Luís Tavares, Frederico Aires-da-Silva
INTRODUCTION: Cancer is a major public health problem with over 19 million cases reported in 2020. Similarly to humans, dogs are also largely affected by cancer, with non-Hodgkin's lymphoma (NHL) among the most common cancers in both species. Comparative medicine has the potential to accelerate the development of new therapeutic options in oncology by leveraging commonalities between diseases affecting both humans and animals. Within this context, in the present study, we investigated the potential of panobinostat (Pan)-loaded folate-targeted PEGylated liposomes (FA-PEG-Pan-Lip) for the treatment of canine B-cell lymphoma, while contributing to new perspectives in comparative oncology...
2023: Frontiers in Veterinary Science